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Conserved domains on  [gi|501526680|ref|WP_012533186|]
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MULTISPECIES: DUF4426 domain-containing protein [Aliivibrio]

Protein Classification

DUF4426 domain-containing protein( domain architecture ID 10628020)

DUF4426 domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
DUF4426 pfam14467
Domain of unknown function (DUF4426); Members of this entry are found mostly in ...
 23-142 6.13e-67

Domain of unknown function (DUF4426); Members of this entry are found mostly in g-proteobacteria, especially in Vibrio. Strangely enough, there seems to be one eukaryotic homolog in Nematostella vectensis (NEMVEDRAFT_v1g226006), where the PA0388-like domain is fused with a domain homogous to the Methionine biosynthesis protein MetW (see below). In several Pseudomonas species, but also in Vibrio vulnificus and Azotobacter vinelandii PA0388 homologs are genomic neighbors of Nucleoside 5-triphosphatase RdgB (dHAPTP, dITP, XTP-specific) (EC 3.6.1.15) and Methionine biosynthesis protein MetW. On the other hand, in most Vibrio species it appears as a part of a conserved operon involved in possible response to stress.


:

Pssm-ID: 433974  Cd Length: 120  Bit Score: 198.56  E-value: 6.13e-67
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501526680   23 VQIKNVEVHYSAFNSTFLTPKVARAYQLKRSGYNALLNISVLDISQAGKPAISATISGSAKNLLGQTKQLTFREIKEQNA 102
Cdd:pfam14467   1 QDFGDYEVHYSAFNSTFLTPEVARAYGIERSKYRGLVNISVLKKSGDGNPAVPAQVSGTARNLLGQVRTLEFREIREGDA 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 501526680  103 IYYIAELPITNEETFRFDIDVSAGTKGAGKLKFNQKFYVE 142
Cdd:pfam14467  81 IYYLAEFPISNEEVLTFDIDVPEGNEQPLTLKFQQKFYVD 120
 
Name Accession Description Interval E-value
DUF4426 pfam14467
Domain of unknown function (DUF4426); Members of this entry are found mostly in ...
 23-142 6.13e-67

Domain of unknown function (DUF4426); Members of this entry are found mostly in g-proteobacteria, especially in Vibrio. Strangely enough, there seems to be one eukaryotic homolog in Nematostella vectensis (NEMVEDRAFT_v1g226006), where the PA0388-like domain is fused with a domain homogous to the Methionine biosynthesis protein MetW (see below). In several Pseudomonas species, but also in Vibrio vulnificus and Azotobacter vinelandii PA0388 homologs are genomic neighbors of Nucleoside 5-triphosphatase RdgB (dHAPTP, dITP, XTP-specific) (EC 3.6.1.15) and Methionine biosynthesis protein MetW. On the other hand, in most Vibrio species it appears as a part of a conserved operon involved in possible response to stress.


Pssm-ID: 433974  Cd Length: 120  Bit Score: 198.56  E-value: 6.13e-67
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501526680   23 VQIKNVEVHYSAFNSTFLTPKVARAYQLKRSGYNALLNISVLDISQAGKPAISATISGSAKNLLGQTKQLTFREIKEQNA 102
Cdd:pfam14467   1 QDFGDYEVHYSAFNSTFLTPEVARAYGIERSKYRGLVNISVLKKSGDGNPAVPAQVSGTARNLLGQVRTLEFREIREGDA 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 501526680  103 IYYIAELPITNEETFRFDIDVSAGTKGAGKLKFNQKFYVE 142
Cdd:pfam14467  81 IYYLAEFPISNEEVLTFDIDVPEGNEQPLTLKFQQKFYVD 120
 
Name Accession Description Interval E-value
DUF4426 pfam14467
Domain of unknown function (DUF4426); Members of this entry are found mostly in ...
 23-142 6.13e-67

Domain of unknown function (DUF4426); Members of this entry are found mostly in g-proteobacteria, especially in Vibrio. Strangely enough, there seems to be one eukaryotic homolog in Nematostella vectensis (NEMVEDRAFT_v1g226006), where the PA0388-like domain is fused with a domain homogous to the Methionine biosynthesis protein MetW (see below). In several Pseudomonas species, but also in Vibrio vulnificus and Azotobacter vinelandii PA0388 homologs are genomic neighbors of Nucleoside 5-triphosphatase RdgB (dHAPTP, dITP, XTP-specific) (EC 3.6.1.15) and Methionine biosynthesis protein MetW. On the other hand, in most Vibrio species it appears as a part of a conserved operon involved in possible response to stress.


Pssm-ID: 433974  Cd Length: 120  Bit Score: 198.56  E-value: 6.13e-67
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501526680   23 VQIKNVEVHYSAFNSTFLTPKVARAYQLKRSGYNALLNISVLDISQAGKPAISATISGSAKNLLGQTKQLTFREIKEQNA 102
Cdd:pfam14467   1 QDFGDYEVHYSAFNSTFLTPEVARAYGIERSKYRGLVNISVLKKSGDGNPAVPAQVSGTARNLLGQVRTLEFREIREGDA 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 501526680  103 IYYIAELPITNEETFRFDIDVSAGTKGAGKLKFNQKFYVE 142
Cdd:pfam14467  81 IYYLAEFPISNEEVLTFDIDVPEGNEQPLTLKFQQKFYVD 120
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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