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Conserved domains on  [gi|501569583|ref|WP_012574012|]
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DUF4825 domain-containing protein [Anoxybacillus flavithermus]

Protein Classification

DUF4825 domain-containing protein( domain architecture ID 11240931)

DUF4825 domain-containing protein, similar to N-terminal, extracellular domain of some homologs of Staph BlaR1 proteases, where it replaces the penicillin-binding domain of BlaR1

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
DUF4825 pfam16107
Domain of unknown function (DUF4825); This domain forms the N-terminal, extracellular domain ...
 41-133 1.01e-28

Domain of unknown function (DUF4825); This domain forms the N-terminal, extracellular domain of some homologs of Staph BlaR1 proteases, where it replaces the penicillin-binding domain of BlaR1. It is also found in many uncharacterized proteins in a broad range of bacteria. Its association with BlaR1 homologs suggests it may be involved in substrate-, possibly antibiotic-binding, but this prediction has not been verified experimentally.


:

Pssm-ID: 435140  Cd Length: 95  Bit Score: 107.73  E-value: 1.01e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501569583   41 LFSYKSQYVGDVSNVSGLLDQLAFGTYRR--SVSLQTVKEPYGMTVHYDMENTEMGLKKIEKLLYDNAVILFVLIENLDR 118
Cdd:pfam16107   1 LYKYKTPYVGDNSKVGKILGALPLPEGLGyyGIELQTSKEPYGLTVNYEEKDTKDEEEELKDTMKRNAVILFALIDNLDY 80

                          90
                  ....*....|....*
gi 501569583  119 ITFDMNVDAKHVSYS 133
Cdd:pfam16107  81 ITFEYSDDETTYTFT 95
 
Name Accession Description Interval E-value
DUF4825 pfam16107
Domain of unknown function (DUF4825); This domain forms the N-terminal, extracellular domain ...
 41-133 1.01e-28

Domain of unknown function (DUF4825); This domain forms the N-terminal, extracellular domain of some homologs of Staph BlaR1 proteases, where it replaces the penicillin-binding domain of BlaR1. It is also found in many uncharacterized proteins in a broad range of bacteria. Its association with BlaR1 homologs suggests it may be involved in substrate-, possibly antibiotic-binding, but this prediction has not been verified experimentally.


Pssm-ID: 435140  Cd Length: 95  Bit Score: 107.73  E-value: 1.01e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501569583   41 LFSYKSQYVGDVSNVSGLLDQLAFGTYRR--SVSLQTVKEPYGMTVHYDMENTEMGLKKIEKLLYDNAVILFVLIENLDR 118
Cdd:pfam16107   1 LYKYKTPYVGDNSKVGKILGALPLPEGLGyyGIELQTSKEPYGLTVNYEEKDTKDEEEELKDTMKRNAVILFALIDNLDY 80

                          90
                  ....*....|....*
gi 501569583  119 ITFDMNVDAKHVSYS 133
Cdd:pfam16107  81 ITFEYSDDETTYTFT 95
 
Name Accession Description Interval E-value
DUF4825 pfam16107
Domain of unknown function (DUF4825); This domain forms the N-terminal, extracellular domain ...
 41-133 1.01e-28

Domain of unknown function (DUF4825); This domain forms the N-terminal, extracellular domain of some homologs of Staph BlaR1 proteases, where it replaces the penicillin-binding domain of BlaR1. It is also found in many uncharacterized proteins in a broad range of bacteria. Its association with BlaR1 homologs suggests it may be involved in substrate-, possibly antibiotic-binding, but this prediction has not been verified experimentally.


Pssm-ID: 435140  Cd Length: 95  Bit Score: 107.73  E-value: 1.01e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501569583   41 LFSYKSQYVGDVSNVSGLLDQLAFGTYRR--SVSLQTVKEPYGMTVHYDMENTEMGLKKIEKLLYDNAVILFVLIENLDR 118
Cdd:pfam16107   1 LYKYKTPYVGDNSKVGKILGALPLPEGLGyyGIELQTSKEPYGLTVNYEEKDTKDEEEELKDTMKRNAVILFALIDNLDY 80

                          90
                  ....*....|....*
gi 501569583  119 ITFDMNVDAKHVSYS 133
Cdd:pfam16107  81 ITFEYSDDETTYTFT 95
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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