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MULTISPECIES: Lrp/AsnC family transcriptional regulator [Vibrio]

Protein Classification

Lrp/AsnC family transcriptional regulator( domain architecture ID 11445815)

Lrp/AsnC (leucine-responsive regulatory protein/asparagine synthase C) family transcriptional regulator regulates many cellular processes such as amino acid metabolism, pili synthesis, and DNA repair and recombination

Gene Ontology:  GO:0043565

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
Lrp COG1522
DNA-binding transcriptional regulator, Lrp family [Transcription];
1-139 6.04e-38

DNA-binding transcriptional regulator, Lrp family [Transcription];


:

Pssm-ID: 441131 [Multi-domain]  Cd Length: 138  Bit Score: 126.05  E-value: 6.04e-38
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501606764   1 MDKFDRQILDILKTNARCSVSDIARDVSLSRSAVNARIKKLENDKIITGYSAQVTEPDLPKNVGAYISLKFDmsssNHNC 80
Cdd:COG1522    3 LDEIDRRILRLLQEDGRLSFAELAERVGLSESTVLRRVRRLEEAGVIRGYGAVVDPEKLGLGVTAFVEVKVP----PHRL 78
                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 501606764  81 ESYAKNIYAIDGVQWCHSISGETDMMLYVEVESMERLNQ-IRDQLQGYPELRHLMTHTVL 139
Cdd:COG1522   79 DEFAEALAAIPEVLECYLVTGDYDLLLKVVARDMEELERfLLERLAALPGVRRTETSFVL 138
 
Name Accession Description Interval E-value
Lrp COG1522
DNA-binding transcriptional regulator, Lrp family [Transcription];
1-139 6.04e-38

DNA-binding transcriptional regulator, Lrp family [Transcription];


Pssm-ID: 441131 [Multi-domain]  Cd Length: 138  Bit Score: 126.05  E-value: 6.04e-38
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501606764   1 MDKFDRQILDILKTNARCSVSDIARDVSLSRSAVNARIKKLENDKIITGYSAQVTEPDLPKNVGAYISLKFDmsssNHNC 80
Cdd:COG1522    3 LDEIDRRILRLLQEDGRLSFAELAERVGLSESTVLRRVRRLEEAGVIRGYGAVVDPEKLGLGVTAFVEVKVP----PHRL 78
                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 501606764  81 ESYAKNIYAIDGVQWCHSISGETDMMLYVEVESMERLNQ-IRDQLQGYPELRHLMTHTVL 139
Cdd:COG1522   79 DEFAEALAAIPEVLECYLVTGDYDLLLKVVARDMEELERfLLERLAALPGVRRTETSFVL 138
HTH_ASNC smart00344
helix_turn_helix ASNC type; AsnC: an autogenously regulated activator of asparagine synthetase ...
1-109 2.37e-21

helix_turn_helix ASNC type; AsnC: an autogenously regulated activator of asparagine synthetase A transcription in Escherichia coli)


Pssm-ID: 214628 [Multi-domain]  Cd Length: 108  Bit Score: 82.95  E-value: 2.37e-21
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501606764     1 MDKFDRQILDILKTNARCSVSDIARDVSLSRSAVNARIKKLENDKIITGYSAQVTEPDLPKNVGAYISLKFDmssSNHNC 80
Cdd:smart00344   1 LDEIDRKILEELQKDARISLAELAKKVGLSPSTVHNRVKRLEEEGVIKGYTAVLNPKKLGLSVTAFVGVTLE---NPDKL 77
                           90       100
                   ....*....|....*....|....*....
gi 501606764    81 ESYAKNIYAIDGVQWCHSISGETDMMLYV 109
Cdd:smart00344  78 EEFLEKLEKLPEVEEVYLVTGDYDYLLKV 106
HTH_AsnC-type pfam13404
AsnC-type helix-turn-helix domain;
2-42 1.52e-15

AsnC-type helix-turn-helix domain;


Pssm-ID: 433180 [Multi-domain]  Cd Length: 41  Bit Score: 65.85  E-value: 1.52e-15
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 501606764    2 DKFDRQILDILKTNARCSVSDIARDVSLSRSAVNARIKKLE 42
Cdd:pfam13404   1 DEIDRKILRLLQEDARISFAELAERVGLSESTVLRRIRRLE 41
PRK11169 PRK11169
leucine-responsive transcriptional regulator Lrp;
1-148 2.60e-10

leucine-responsive transcriptional regulator Lrp;


Pssm-ID: 183009 [Multi-domain]  Cd Length: 164  Bit Score: 55.54  E-value: 2.60e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501606764   1 MDKFDRQILDILKTNARCSVSDIARDVSLSRSAVNARIKKLENDKIITGYSAQVTEPDLPKNVGAYISLKFDMSSSNhNC 80
Cdd:PRK11169  12 LDRIDRNILNELQKDGRISNVELSKRVGLSPTPCLERVRRLERQGFIQGYTALLNPHYLDASLLVFVEITLNRGAPD-VF 90
                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 501606764  81 ESYAKNIYAIDGVQWCHSISGETDMMLYVEVESMERLNQIR-DQLQGYPELRHLMTHTVLTEFfnKQTS 148
Cdd:PRK11169  91 EQFNAAVQKLEEIQECHLVSGDFDYLLKTRVPDMSAYRKLLgETLLRLPGVNDTRTYVVMEEV--KQTN 157
HTH_ARSR cd00090
Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric ...
2-50 5.81e-07

Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to dissociate from DNA in the presence of metal ions.


Pssm-ID: 238042 [Multi-domain]  Cd Length: 78  Bit Score: 44.60  E-value: 5.81e-07
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*....
gi 501606764   2 DKFDRQILDILKTNaRCSVSDIARDVSLSRSAVNARIKKLENDKIITGY 50
Cdd:cd00090    6 DPTRLRILRLLLEG-PLTVSELAERLGLSQSTVSRHLKKLEEAGLVESR 53
HTH_metalloreg NF033788
metalloregulator ArsR/SmtB family transcription factor; Transcriptional repressors that sense ...
6-49 4.57e-03

metalloregulator ArsR/SmtB family transcription factor; Transcriptional repressors that sense toxic heavy metals such as arsenic or cadmium, and are released from DNA so that resistance factors will be expressed, include ArsR, SmtB, ZiaR, CadC, CadX, KmtR, etc. However, some members of this family, including the sporulation delaying system autorepressor SdpR and its family (see NF033789), may lack metal-binding cites and instead regulate other cellular processes.


Pssm-ID: 411368 [Multi-domain]  Cd Length: 76  Bit Score: 33.97  E-value: 4.57e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....
gi 501606764   6 RQILDILKTNARCsVSDIARDVSLSRSAVNARIKKLENDKIITG 49
Cdd:NF033788  14 LRILELLAEGELC-VCELAEALGLSQSAVSQHLKVLRDAGLVTS 56
 
Name Accession Description Interval E-value
Lrp COG1522
DNA-binding transcriptional regulator, Lrp family [Transcription];
1-139 6.04e-38

DNA-binding transcriptional regulator, Lrp family [Transcription];


Pssm-ID: 441131 [Multi-domain]  Cd Length: 138  Bit Score: 126.05  E-value: 6.04e-38
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501606764   1 MDKFDRQILDILKTNARCSVSDIARDVSLSRSAVNARIKKLENDKIITGYSAQVTEPDLPKNVGAYISLKFDmsssNHNC 80
Cdd:COG1522    3 LDEIDRRILRLLQEDGRLSFAELAERVGLSESTVLRRVRRLEEAGVIRGYGAVVDPEKLGLGVTAFVEVKVP----PHRL 78
                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 501606764  81 ESYAKNIYAIDGVQWCHSISGETDMMLYVEVESMERLNQ-IRDQLQGYPELRHLMTHTVL 139
Cdd:COG1522   79 DEFAEALAAIPEVLECYLVTGDYDLLLKVVARDMEELERfLLERLAALPGVRRTETSFVL 138
HTH_ASNC smart00344
helix_turn_helix ASNC type; AsnC: an autogenously regulated activator of asparagine synthetase ...
1-109 2.37e-21

helix_turn_helix ASNC type; AsnC: an autogenously regulated activator of asparagine synthetase A transcription in Escherichia coli)


Pssm-ID: 214628 [Multi-domain]  Cd Length: 108  Bit Score: 82.95  E-value: 2.37e-21
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501606764     1 MDKFDRQILDILKTNARCSVSDIARDVSLSRSAVNARIKKLENDKIITGYSAQVTEPDLPKNVGAYISLKFDmssSNHNC 80
Cdd:smart00344   1 LDEIDRKILEELQKDARISLAELAKKVGLSPSTVHNRVKRLEEEGVIKGYTAVLNPKKLGLSVTAFVGVTLE---NPDKL 77
                           90       100
                   ....*....|....*....|....*....
gi 501606764    81 ESYAKNIYAIDGVQWCHSISGETDMMLYV 109
Cdd:smart00344  78 EEFLEKLEKLPEVEEVYLVTGDYDYLLKV 106
HTH_AsnC-type pfam13404
AsnC-type helix-turn-helix domain;
2-42 1.52e-15

AsnC-type helix-turn-helix domain;


Pssm-ID: 433180 [Multi-domain]  Cd Length: 41  Bit Score: 65.85  E-value: 1.52e-15
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 501606764    2 DKFDRQILDILKTNARCSVSDIARDVSLSRSAVNARIKKLE 42
Cdd:pfam13404   1 DEIDRKILRLLQEDARISFAELAERVGLSESTVLRRIRRLE 41
HTH_24 pfam13412
Winged helix-turn-helix DNA-binding;
3-47 2.97e-12

Winged helix-turn-helix DNA-binding;


Pssm-ID: 404317 [Multi-domain]  Cd Length: 45  Bit Score: 57.44  E-value: 2.97e-12
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 501606764    3 KFDRQILDILKTNARCSVSDIARDVSLSRSAVNARIKKLENDKII 47
Cdd:pfam13412   1 ETDRKILNLLQENPRISQRELAERLGLSPSTVNRRLKRLEEEGVI 45
AsnC_trans_reg pfam01037
Lrp/AsnC ligand binding domain; The l-leucine-responsive regulatory protein (Lrp/AsnC) family ...
75-139 4.35e-11

Lrp/AsnC ligand binding domain; The l-leucine-responsive regulatory protein (Lrp/AsnC) family is a family of similar bacterial transcription regulatory proteins. The family is named after two E. coli proteins involved in regulating amino acid metabolism. This entry corresponds to the usually C-terminal regulatory ligand binding domain. Structurally this domain has a dimeric alpha/beta barrel fold. This domain binds almost exclusively amino acids but also 4-hydroxyphenylpyruvate and kynurenine (Matilla et. al., FEMS Microbiology Reviews, fuab043, 45, 2021, 1. https://doi.org/10.1093/femsre/fuab043).


Pssm-ID: 426007  Cd Length: 73  Bit Score: 55.22  E-value: 4.35e-11
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 501606764   75 SSNHNCESYAKNIYAIDGVQWCHSISGETDMMLYVEVESMERLNQ-IRDQLQGYPELRHLMTHTVL 139
Cdd:pfam01037   6 EPGHALEEFAEALAAIPEVVECYRVTGDYDYLLKVVARDLEALERfLREKLRSLPGVARTETSIVL 71
PRK11169 PRK11169
leucine-responsive transcriptional regulator Lrp;
1-148 2.60e-10

leucine-responsive transcriptional regulator Lrp;


Pssm-ID: 183009 [Multi-domain]  Cd Length: 164  Bit Score: 55.54  E-value: 2.60e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501606764   1 MDKFDRQILDILKTNARCSVSDIARDVSLSRSAVNARIKKLENDKIITGYSAQVTEPDLPKNVGAYISLKFDMSSSNhNC 80
Cdd:PRK11169  12 LDRIDRNILNELQKDGRISNVELSKRVGLSPTPCLERVRRLERQGFIQGYTALLNPHYLDASLLVFVEITLNRGAPD-VF 90
                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 501606764  81 ESYAKNIYAIDGVQWCHSISGETDMMLYVEVESMERLNQIR-DQLQGYPELRHLMTHTVLTEFfnKQTS 148
Cdd:PRK11169  91 EQFNAAVQKLEEIQECHLVSGDFDYLLKTRVPDMSAYRKLLgETLLRLPGVNDTRTYVVMEEV--KQTN 157
HTH_ARSR cd00090
Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric ...
2-50 5.81e-07

Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to dissociate from DNA in the presence of metal ions.


Pssm-ID: 238042 [Multi-domain]  Cd Length: 78  Bit Score: 44.60  E-value: 5.81e-07
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*....
gi 501606764   2 DKFDRQILDILKTNaRCSVSDIARDVSLSRSAVNARIKKLENDKIITGY 50
Cdd:cd00090    6 DPTRLRILRLLLEG-PLTVSELAERLGLSQSTVSRHLKKLEEAGLVESR 53
PRK11179 PRK11179
DNA-binding transcriptional regulator AsnC; Provisional
1-67 2.46e-06

DNA-binding transcriptional regulator AsnC; Provisional


Pssm-ID: 183019 [Multi-domain]  Cd Length: 153  Bit Score: 44.70  E-value: 2.46e-06
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 501606764   1 MDKFDRQILDILKTNARCSVSDIARDVSLSRSAVNARIKKLENDKIITGYSAQVTEPDLPKNVGAYI 67
Cdd:PRK11179   7 IDNLDRGILEALMENARTPYAELAKQFGVSPGTIHVRVEKMKQAGIITGTRVDVNPKQLGYDVCCFI 73
HTH_MARR smart00347
helix_turn_helix multiple antibiotic resistance protein;
8-42 1.81e-04

helix_turn_helix multiple antibiotic resistance protein;


Pssm-ID: 197670 [Multi-domain]  Cd Length: 101  Bit Score: 38.34  E-value: 1.81e-04
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 501606764     8 ILDILKTNARCSVSDIARDVSLSRSAVNARIKKLE 42
Cdd:smart00347  15 VLRILYEEGPLSVSELAKRLGVSPSTVTRVLDRLE 49
COG2512 COG2512
Predicted transcriptional regulator, contains CW (cell wall-binding) repeats and an HTH domain ...
5-48 1.96e-04

Predicted transcriptional regulator, contains CW (cell wall-binding) repeats and an HTH domain [General function prediction only];


Pssm-ID: 442002 [Multi-domain]  Cd Length: 80  Bit Score: 37.97  E-value: 1.96e-04
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*
gi 501606764   5 DRQILDILKTNA-RCSVSDIARDVSLSRSAVNARIKKLENDKIIT 48
Cdd:COG2512   17 ERRVLELLRENGgRMTQSEIVKETGWSKSKVSRLLSRLEERGLIE 61
COG2345 COG2345
Predicted transcriptional regulator, ArsR family [Transcription];
6-48 3.18e-04

Predicted transcriptional regulator, ArsR family [Transcription];


Pssm-ID: 441914 [Multi-domain]  Cd Length: 217  Bit Score: 39.14  E-value: 3.18e-04
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|...
gi 501606764   6 RQILDILKTNARCSVSDIARDVSLSRSAVNARIKKLENDKIIT 48
Cdd:COG2345   16 RRILELLKRAGPVTAAELAEALGLTPNAVRRHLDALEEEGLVE 58
COG3398 COG3398
Predicted transcriptional regulator, contains two HTH domains [Transcription];
5-48 3.32e-04

Predicted transcriptional regulator, contains two HTH domains [Transcription];


Pssm-ID: 442625 [Multi-domain]  Cd Length: 159  Bit Score: 38.71  E-value: 3.32e-04
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....
gi 501606764   5 DRQILDILKTNARCSVSDIARDVSLSRSAVNARIKKLENDKIIT 48
Cdd:COG3398   99 PRRILLYLLENPGATNKELAEELGISRSTVSWHLKRLEEDGLVE 142
HTH_ARSR smart00418
helix_turn_helix, Arsenical Resistance Operon Repressor;
7-48 4.40e-04

helix_turn_helix, Arsenical Resistance Operon Repressor;


Pssm-ID: 197713 [Multi-domain]  Cd Length: 66  Bit Score: 36.80  E-value: 4.40e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 501606764     7 QILDILKtNARCSVSDIARDVSLSRSAVNARIKKLENDKIIT 48
Cdd:smart00418   1 KILKLLA-EGELCVCELAEILGLSQSTVSHHLKKLREAGLVE 41
MarR_2 pfam12802
MarR family; The Mar proteins are involved in the multiple antibiotic resistance, a ...
7-48 5.94e-04

MarR family; The Mar proteins are involved in the multiple antibiotic resistance, a non-specific resistance system. The expression of the mar operon is controlled by a repressor, MarR. A large number of compounds induce transcription of the mar operon. This is thought to be due to the compound binding to MarR, and the resulting complex stops MarR binding to the DNA. With the MarR repression lost, transcription of the operon proceeds. The structure of MarR is known and shows MarR as a dimer with each subunit containing a winged-helix DNA binding motif.


Pssm-ID: 432797 [Multi-domain]  Cd Length: 60  Bit Score: 36.03  E-value: 5.94e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 501606764    7 QILDILKTNARCSVSDIARDVSLSRSAVNARIKKLENDKIIT 48
Cdd:pfam12802   9 RVLLALARNPGLTVAELARRLGISKQTVSRLVKRLEAKGLVE 50
BirA COG1654
Biotin operon repressor [Transcription];
1-50 7.87e-04

Biotin operon repressor [Transcription];


Pssm-ID: 441260 [Multi-domain]  Cd Length: 324  Bit Score: 38.43  E-value: 7.87e-04
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|
gi 501606764   1 MDKFDRQILDILKTNARCSVSDIARDVSLSRSAVNARIKKLENDkiitGY 50
Cdd:COG1654    2 MSSTRLKLLRLLADGEFHSGEELAEELGVSRAAVWKHIKALREL----GY 47
HTH_20 pfam12840
Helix-turn-helix domain; This domain represents a DNA-binding Helix-turn-helix domain found in ...
6-48 8.12e-04

Helix-turn-helix domain; This domain represents a DNA-binding Helix-turn-helix domain found in transcriptional regulatory proteins.


Pssm-ID: 432824 [Multi-domain]  Cd Length: 61  Bit Score: 35.98  E-value: 8.12e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 501606764    6 RQILDILKTNARCSVSDIARDVSLSRSAVNARIKKLENDKIIT 48
Cdd:pfam12840  13 LRILRALVGDEPLTASELARRLDISRNTLSYHLRKLEEAGLVE 55
COG3888 COG3888
Predicted transcriptional regulator [Transcription];
1-47 1.35e-03

Predicted transcriptional regulator [Transcription];


Pssm-ID: 443096 [Multi-domain]  Cd Length: 328  Bit Score: 37.69  E-value: 1.35e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*....
gi 501606764   1 MDKFDRQILDILKTNARCSV--SDIARDVSLSRSAVNARIKKLENDKII 47
Cdd:COG3888    1 MMSLREKILRILKNYGGEGIpqSELVRLLGASKSRVSEILSELEKEGLI 49
MarR COG1846
DNA-binding transcriptional regulator, MarR family [Transcription];
7-48 1.78e-03

DNA-binding transcriptional regulator, MarR family [Transcription];


Pssm-ID: 441451 [Multi-domain]  Cd Length: 142  Bit Score: 36.49  E-value: 1.78e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|..
gi 501606764   7 QILDILKTNARCSVSDIARDVSLSRSAVNARIKKLENDKIIT 48
Cdd:COG1846   42 RVLAALAEAGGLTQSELAERLGLTKSTVSRLLDRLEEKGLVE 83
PRK09954 PRK09954
sugar kinase;
1-65 2.84e-03

sugar kinase;


Pssm-ID: 182165 [Multi-domain]  Cd Length: 362  Bit Score: 36.83  E-value: 2.84e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 501606764   1 MDKFDRQILDILKTNARCSVSDIARDVSLSRSAVNARIKKLENDKIITGYSAQVTEPDLPKNVGA 65
Cdd:PRK09954   1 MNNREKEILAILRRNPLIQQNEIADILQISRSRVAAHIMDLMRKGRIKGKGYILTEQEYCVVVGA 65
MarR pfam01047
MarR family; The Mar proteins are involved in the multiple antibiotic resistance, a ...
8-48 4.48e-03

MarR family; The Mar proteins are involved in the multiple antibiotic resistance, a non-specific resistance system. The expression of the mar operon is controlled by a repressor, MarR. A large number of compounds induce transcription of the mar operon. This is thought to be due to the compound binding to MarR, and the resulting complex stops MarR binding to the DNA. With the MarR repression lost, transcription of the operon proceeds. The structure of MarR is known and shows MarR as a dimer with each subunit containing a winged-helix DNA binding motif.


Pssm-ID: 426012 [Multi-domain]  Cd Length: 59  Bit Score: 33.67  E-value: 4.48e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 501606764    8 ILDILKTNARCSVSDIARDVSLSRSAVNARIKKLENDKIIT 48
Cdd:pfam01047   8 ILRILYEHGPLTVSELAEKLGVSKSTVTRVLDRLEKKGLIE 48
HTH_metalloreg NF033788
metalloregulator ArsR/SmtB family transcription factor; Transcriptional repressors that sense ...
6-49 4.57e-03

metalloregulator ArsR/SmtB family transcription factor; Transcriptional repressors that sense toxic heavy metals such as arsenic or cadmium, and are released from DNA so that resistance factors will be expressed, include ArsR, SmtB, ZiaR, CadC, CadX, KmtR, etc. However, some members of this family, including the sporulation delaying system autorepressor SdpR and its family (see NF033789), may lack metal-binding cites and instead regulate other cellular processes.


Pssm-ID: 411368 [Multi-domain]  Cd Length: 76  Bit Score: 33.97  E-value: 4.57e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....
gi 501606764   6 RQILDILKTNARCsVSDIARDVSLSRSAVNARIKKLENDKIITG 49
Cdd:NF033788  14 LRILELLAEGELC-VCELAEALGLSQSAVSQHLKVLRDAGLVTS 56
ArsR COG0640
DNA-binding transcriptional regulator, ArsR family [Transcription];
6-48 7.97e-03

DNA-binding transcriptional regulator, ArsR family [Transcription];


Pssm-ID: 440405 [Multi-domain]  Cd Length: 92  Bit Score: 33.71  E-value: 7.97e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|...
gi 501606764   6 RQILDILKTNARCsVSDIARDVSLSRSAVNARIKKLENDKIIT 48
Cdd:COG0640   23 LRILRLLAEGELC-VGELAEALGLSQSTVSHHLKVLREAGLVT 64
HTH_5 pfam01022
Bacterial regulatory protein, arsR family; Members of this family contains a DNA binding ...
6-47 9.68e-03

Bacterial regulatory protein, arsR family; Members of this family contains a DNA binding 'helix-turn-helix' motif. This family includes other proteins which are not included in the Prosite definition.


Pssm-ID: 425993 [Multi-domain]  Cd Length: 45  Bit Score: 32.42  E-value: 9.68e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 501606764    6 RQILDILKTNARCsVSDIARDVSLSRSAVNARIKKLENDKII 47
Cdd:pfam01022   5 LKILKLLAEGELC-VCELAEELGLSQSTVSHHLKKLREAGLV 45
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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