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Conserved domains on  [gi|501624753|ref|WP_012603375|]
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MULTISPECIES: penicillin-binding protein 2 [Vibrio]

Protein Classification

penicillin-binding protein 2( domain architecture ID 11496821)

penicillin-binding protein (PBP) 2 is a membrane-associated enzyme that is involved in the synthesis of cross-linked peptidoglycan

EC:  3.4.16.4
Gene Ontology:  GO:0009252|GO:0008658|GO:0016020
PubMed:  18266856|18248419

Graphical summary

 Zoom to residue level

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List of domain hits

 Name Accession Description Interval E-value
pbp2_mrdA TIGR03423
penicillin-binding protein 2; Members of this protein family are penicillin-binding protein 2 ...
 20-620 0e+00

penicillin-binding protein 2; Members of this protein family are penicillin-binding protein 2 (PBP-2), a protein whose gene (designated pbpA or mrdA) generally is found next to the gene for RodA, a protein required for rod (bacillus) shape in many bacteria. PBP-2 acts as a transpeptidase for cell elongation (hence, rod-shape). [Cell envelope, Biosynthesis and degradation of murein sacculus and peptidoglycan]


:

Pssm-ID: 274573 [Multi-domain]  Cd Length: 592  Bit Score: 911.91  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501624753   20 SRAFVAFAGIIVMMSLLVVNLYNIQVNQYQDYKTRSNDNRIKVVPIAPNRGLIYDRNGVLLAENRPVFNLEITPEKVKNM 99
Cdd:TIGR03423   1 RRALVLGGLVLALFGVLAARLFYLQVIRGEEYATLSEDNRIRLVPIPPPRGLILDRNGVLLADNRPSFSLEIVPEKVDDL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501624753  100 EDTLVRLQALIDIPPERIERFNRDRRNSRRFKSVPILNQLTEEQVAVFSVNQHKFPGVEVTGTLKRFYPYGDVLTHVIGY 179
Cdd:TIGR03423  81 DATLDRLAKLLDLDPEDIARFLKELKRSRRFEPIPLKSDLTEEEVARFAVNQYRLPGVEIEARLKRYYPYGELAAHVLGY 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501624753  180 VSRINDRDMQRLvreeKDANYQATRDIGKLGIERYYEDMLHGTAGYQEVEVNSRGRVIRTLKFVPSAPGKDIVLNLDIKL 259
Cdd:TIGR03423 161 VGEINEEDLERL----EPANYAGGDYIGKSGIEKYYEDELRGKPGYREVEVNARGRVIRTLSRVPPVPGKDLVLTIDARL 236

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501624753  260 QLYVHKLLDGRRGSAVVLDPKDNGVLAMVSSPSYDPNAFVHGISSKGYNALLQDKDRPLVNRATLGIYPPASTIKPFIAV 339
Cdd:TIGR03423 237 QQAAEKALGGRRGAVVVMDPRTGEILAMVSTPSFDPNLFVDGISSKDYKALLNDPDRPLLNRAIQGVYPPGSTFKPVVAL 316

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501624753  340 AALQEGVITPNTTRNDPGYWKIPNsktKPFRDWLRWGHGVVDIEKAIEESVDTFFYQISFDLGIDRLSKWMMLFGFGDYT 419
Cdd:TIGR03423 317 AALEEGVITPETRIYCPGYFQLGG---RRFRCWKRGGHGRVDLRKAIEESCDVYFYQLALRLGIDKIAEYAKRFGFGQKT 393

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501624753  420 GIDIYEESKANMPTREWKMARHRVPWYQGDTIPVGIGQGYWTATPMQIAKATSVLVNEGEVTAPHLLRATIENgqpfDEQ 499
Cdd:TIGR03423 394 GIDLPGEKSGLVPSREWKRKRFGQPWYPGDTLNVSIGQGYVLVTPLQLAVATAALANGGKLYKPHLVKSIEDP----DGG 469

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501624753  500 TISEIET-YPPVTGVKQRYWDIAQEGMRLVNHGKKGTARRSFQKMSYQTAGKSGTAQVFGLKEDEEYNADEIAEHLRDHA 578
Cdd:TIGR03423 470 VVRRTEPeVLRPLPISPENLDVVREGMRDVVNGPGGTARRARLGLPYKMAGKTGTAQVVSLKQGEKYDAEQIPERLRDHA 549

                         570       580       590       600
                  ....*....|....*....|....*....|....*....|..
gi 501624753  579 LFTGYAPFEDPEAVVTIVLENAGGGSSNGGPVVRRILDHIIL 620
Cdd:TIGR03423 550 LFVAFAPYDNPKIAVAVIVEHGGGGSSAAAPIARKIMDAYLL 591
 
Name Accession Description Interval E-value
pbp2_mrdA TIGR03423
penicillin-binding protein 2; Members of this protein family are penicillin-binding protein 2 ...
 20-620 0e+00

penicillin-binding protein 2; Members of this protein family are penicillin-binding protein 2 (PBP-2), a protein whose gene (designated pbpA or mrdA) generally is found next to the gene for RodA, a protein required for rod (bacillus) shape in many bacteria. PBP-2 acts as a transpeptidase for cell elongation (hence, rod-shape). [Cell envelope, Biosynthesis and degradation of murein sacculus and peptidoglycan]


Pssm-ID: 274573 [Multi-domain]  Cd Length: 592  Bit Score: 911.91  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501624753   20 SRAFVAFAGIIVMMSLLVVNLYNIQVNQYQDYKTRSNDNRIKVVPIAPNRGLIYDRNGVLLAENRPVFNLEITPEKVKNM 99
Cdd:TIGR03423   1 RRALVLGGLVLALFGVLAARLFYLQVIRGEEYATLSEDNRIRLVPIPPPRGLILDRNGVLLADNRPSFSLEIVPEKVDDL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501624753  100 EDTLVRLQALIDIPPERIERFNRDRRNSRRFKSVPILNQLTEEQVAVFSVNQHKFPGVEVTGTLKRFYPYGDVLTHVIGY 179
Cdd:TIGR03423  81 DATLDRLAKLLDLDPEDIARFLKELKRSRRFEPIPLKSDLTEEEVARFAVNQYRLPGVEIEARLKRYYPYGELAAHVLGY 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501624753  180 VSRINDRDMQRLvreeKDANYQATRDIGKLGIERYYEDMLHGTAGYQEVEVNSRGRVIRTLKFVPSAPGKDIVLNLDIKL 259
Cdd:TIGR03423 161 VGEINEEDLERL----EPANYAGGDYIGKSGIEKYYEDELRGKPGYREVEVNARGRVIRTLSRVPPVPGKDLVLTIDARL 236

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501624753  260 QLYVHKLLDGRRGSAVVLDPKDNGVLAMVSSPSYDPNAFVHGISSKGYNALLQDKDRPLVNRATLGIYPPASTIKPFIAV 339
Cdd:TIGR03423 237 QQAAEKALGGRRGAVVVMDPRTGEILAMVSTPSFDPNLFVDGISSKDYKALLNDPDRPLLNRAIQGVYPPGSTFKPVVAL 316

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501624753  340 AALQEGVITPNTTRNDPGYWKIPNsktKPFRDWLRWGHGVVDIEKAIEESVDTFFYQISFDLGIDRLSKWMMLFGFGDYT 419
Cdd:TIGR03423 317 AALEEGVITPETRIYCPGYFQLGG---RRFRCWKRGGHGRVDLRKAIEESCDVYFYQLALRLGIDKIAEYAKRFGFGQKT 393

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501624753  420 GIDIYEESKANMPTREWKMARHRVPWYQGDTIPVGIGQGYWTATPMQIAKATSVLVNEGEVTAPHLLRATIENgqpfDEQ 499
Cdd:TIGR03423 394 GIDLPGEKSGLVPSREWKRKRFGQPWYPGDTLNVSIGQGYVLVTPLQLAVATAALANGGKLYKPHLVKSIEDP----DGG 469

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501624753  500 TISEIET-YPPVTGVKQRYWDIAQEGMRLVNHGKKGTARRSFQKMSYQTAGKSGTAQVFGLKEDEEYNADEIAEHLRDHA 578
Cdd:TIGR03423 470 VVRRTEPeVLRPLPISPENLDVVREGMRDVVNGPGGTARRARLGLPYKMAGKTGTAQVVSLKQGEKYDAEQIPERLRDHA 549

                         570       580       590       600
                  ....*....|....*....|....*....|....*....|..
gi 501624753  579 LFTGYAPFEDPEAVVTIVLENAGGGSSNGGPVVRRILDHIIL 620
Cdd:TIGR03423 550 LFVAFAPYDNPKIAVAVIVEHGGGGSSAAAPIARKIMDAYLL 591
PRK10795 PRK10795
penicillin-binding protein 2; Provisional
 1-629 0e+00

penicillin-binding protein 2; Provisional


Pssm-ID: 236761 [Multi-domain]  Cd Length: 634  Bit Score: 879.49  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501624753   1 MLRKRSQIRDYKAEARLFTSRAFVAFAGIIVMMSLLVVNLYNIQVNQYQDYKTRSNDNRIKVVPIAPNRGLIYDRNGVLL 80
Cdd:PRK10795   1 MKKLQNSFRDYTAESALFVRRALVAFLGILLLTGVLIANLYNLQIVRFTDYQTRSNENRIKLVPIAPSRGIIYDRNGTPL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501624753  81 AENRPVFNLEITPEKVKNMEDTLVRLQALIDIPPERIERFNRDRRNSRRFKSVPILNQLTEEQVAVFSVNQHKFPGVEVT 160
Cdd:PRK10795  81 ALNRTIYQLEMMPEKVDNLQQTLDALRSVVDLTDDDIAAFRKERARSRRFTSIPVKTNLTEVQVARFAVNQYRFPGVEVK 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501624753 161 GTLKRFYPYGDVLTHVIGYVSRINDRDMQRLVREEKDANYQATRDIGKLGIERYYEDMLHGTAGYQEVEVNSRGRVIRTL 240
Cdd:PRK10795 161 GYQRRYYPYGSALTHVIGYVSKINDKDVERLDKEGKLANYAATHDIGKLGIERYYEDVLHGKTGYEEVEVNNRGRVIRQL 240

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501624753 241 KFVPSAPGKDIVLNLDIKLQLYVHKLLDGRRGSAVVLDPKDNGVLAMVSSPSYDPNAFVHGISSKGYNALLQDKDRPLVN 320
Cdd:PRK10795 241 HEQPPQAGHDIYLTLDLKLQQYIETLLAGSRAAVVVTDPRTGGILALVSTPSYDPNLFVDGISSKDYSGLLNDPNRPLIN 320

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501624753 321 RATLGIYPPASTIKPFIAVAALQEGVITPNTTRNDPGYWKIPNSKtKPFRDWLRWGHGVVDIEKAIEESVDTFFYQISFD 400
Cdd:PRK10795 321 RATQGVYPPASTVKPYVAVSALSAGVITRNTSLFDPGWWQLPGSE-KRYRDWKKWGHGRLNVTKSLEESADTFFYQVAYD 399

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501624753 401 LGIDRLSKWMMLFGFGDYTGIDIYEESKANMPTREWKMARHRVPWYQGDTIPVGIGQGYWTATPMQIAKATSVLVNEGEV 480
Cdd:PRK10795 400 MGIDRLSEWMGKFGYGHYTGIDLAEERSGNMPTREWKQKRFKKPWYQGDTIPVGIGQGYWTATPIQMSKALMTLINDGIV 479

                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501624753 481 TAPHLLRATIENGQ--PFdEQTISeietyPPVTGVKQRYWDIAQEGMRLVNHGKKGTARRSFQKMSYQTAGKSGTAQVFG 558
Cdd:PRK10795 480 KVPHLLMSTAEDGKqvPW-VQPHE-----PPVGDIHSGYWEIAKDGMYGVANRPNGTAHKYFASAPYKIAAKSGTAQVFG 553

                        570       580       590       600       610       620       630
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 501624753 559 LKEDEEYNADEIAEHLRDHALFTGYAPFEDPEAVVTIVLENAGGGSSNGGpVVRRILDHIILAEDYESEPI 629
Cdd:PRK10795 554 LKANETYNAHKIAERLRDHKLMTAFAPYNNPQVAVAIILENGGAGPAVGT-IMRQILDHIMLGDNNTDLPA 623
FtsI COG0768
Cell division protein FtsI, peptidoglycan transpeptidase (Penicillin-binding protein 2) [Cell ...
 12-619 0e+00

Cell division protein FtsI, peptidoglycan transpeptidase (Penicillin-binding protein 2) [Cell cycle control, cell division, chromosome partitioning, Cell wall/membrane/envelope biogenesis];


Pssm-ID: 440531 [Multi-domain]  Cd Length: 568  Bit Score: 611.06  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501624753  12 KAEARLFTSRAFVAFAGIIVMMSLLVVNLYNIQVNQYQDYKTRSNDNRIKVVPIAPNRGLIYDRNGVLLAENRPVFNLEI 91
Cdd:COG0768    4 KKEKRLFRRRLLLLFLLVLLLFLLLVGRLFYLQVVEGDEYAELAEENRIRTVPIPAPRGLIYDRNGNVLATNVPVYSLYA 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501624753  92 TPEKVKNMEDTLVRLQALIDIPPERIERFNRDRRNSrrfkSVPILNQLTEEQVAVfsVNQHKFPGVEVTGTLKRFYPYGD 171
Cdd:COG0768   84 DPEEVKDPEETAEKLAKLLGLDPEELRKKLKKKSRF----PVYLKRNLSPEEAAR--IRALKLPGVYVEAEYKRYYPYGE 157

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501624753 172 VLTHVIGYVSRINDRDmqrlvreekdanyqatrDIGKLGIERYYEDMLHGTAGYQEVEVNSRGRVIRTL-KFVPSAPGKD 250
Cdd:COG0768  158 LAAHVLGYVGEINGGD-----------------GIGKSGLEKAYEDLLRGTPGKRRVEVDARGRVIRDLgEEKPPVPGKD 220

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501624753 251 IVLNLDIKLQLYVHKLLDG-------RRGSAVVLDPKDNGVLAMVSSPSYDPNAFVHGisskgynallqdKDRPLVNRAT 323
Cdd:COG0768  221 LVLTIDSDLQKIAEEALKKaveeykaKSGAVVVMDPKTGEILAMASYPSFDPNLFVGG------------PDEPLRNRAV 288

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501624753 324 LGIYPPASTIKPFIAVAALQEGVITPNTTRNDPGYWKIPNsktKPFRDWLRWGHGVVDIEKAIEESVDTFFYQISFDLGI 403
Cdd:COG0768  289 QGTYEPGSTFKPFTAAAALEEGVITPDTTFDCPGYYRVGG---RTIRDWDRGGHGTLTLTEALAKSSNVGFYKLALRLGI 365

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501624753 404 DRLSKWMMLFGFGDYTGIDIYEESKANMPTREwkmarhrvPWYQGDTIPVGIGQGyWTATPMQIAKATSVLVNEGEVTAP 483
Cdd:COG0768  366 DKLYDYLKKFGLGQKTGIDLPGEASGLLPSPK--------RWYPGETATMSIGQG-LSVTPLQLAQAYAAIANGGVLVKP 436

                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501624753 484 HLLRATIEngqPFDEQTISEIETYPPVtgVKQRYWDIAQEGMRLVNHGKKGTARRSfQKMSYQTAGKSGTAQVFGLKEDE 563
Cdd:COG0768  437 HLVKEIVD---PDGEVVKEEPEVLRRV--ISPETAETVREGMEGVVNEPGGTARRA-AIPGYRVAGKTGTAQVVDIGNGG 510

                        570       580       590       600       610
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 501624753 564 EYnadeiaeHLRDHALFTGYAPFEDPEAVVTIVLENAGGGS---SNGGPVVRRILDHII 619
Cdd:COG0768  511 YY-------KGRHIASFVGFAPADNPRYAVAVVVENPGGGAyggTVAAPVFREIMEAYL 562
Transpeptidase pfam00905
Penicillin binding protein transpeptidase domain; The active site serine (residue 337 in Swiss: ...
 272-616 3.98e-72

Penicillin binding protein transpeptidase domain; The active site serine (residue 337 in Swiss:P14677) is conserved in all members of this family.


Pssm-ID: 425939 [Multi-domain]  Cd Length: 296  Bit Score: 234.23  E-value: 3.98e-72
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501624753  272 GSAVVLDPKDNGVLAMVSSPSYDPNAFVhgisskgynallqdkdRPLVNRATLGIYPPASTIKPFIAVAALQEGVITPNT 351
Cdd:pfam00905   1 GSAVVLDPKTGEVLAMVGKPSYDPNGFI----------------GPLRNRAVTSRYEPGSTFKPFTALAALDNGVLKPDE 64

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501624753  352 TRNDPGYWKIPNsktKPFRDWLRWGHGVVDIEKAIEESVDTFFYQISFDLGIDRLSKWMMLFGFGDYTGIDIYEESkANM 431
Cdd:pfam00905  65 TIFDWPGKQQGG---KSIGDWNQDQVGIGTLRQALEYSSNWYMQKLAQKLGADKLRSYLKKFGYGNKTGIGLPGEN-AGY 140

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501624753  432 PTREwkmarhrvpWYQGDTIPVGIGqgyWTATPMQIAKATSVLVNEGEVTAPHLLRATIE-------NGQPFDEQTISEI 504
Cdd:pfam00905 141 LTPY---------WLEGATASFGIG---LTITPLQQAQAYAAIANGGKLVPPHLVKSIEDkvdpkvlNKLPISKSTAEKV 208

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501624753  505 etyppvtgvkqrywdiaQEGMRLVNHGKKGTARRsfQKMSYQTAGKSGTAQVFGLKEDEEYNAdeiaehlRDHALFTGYA 584
Cdd:pfam00905 209 -----------------KDMLRLVVNDGTGTGTA--AVPGYKVAGKTGTAQVAGPKGGGYYDG-------AQIGWFVGYA 262

                         330       340       350
                  ....*....|....*....|....*....|....
gi 501624753  585 PFEDPEAVVTIVLENAGGGS--SNGGPVVRRILD 616
Cdd:pfam00905 263 PADNPKYAFAVLIDDPKRYYggKVAAPIFKDILE 296
strep_PBP2B NF038278
streptococcal penicillin-binding protein PBP2B;
12-597 2.41e-24

streptococcal penicillin-binding protein PBP2B;


Pssm-ID: 468446 [Multi-domain]  Cd Length: 678  Bit Score: 108.13  E-value: 2.41e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501624753  12 KAEARLFTSRAFVAFAGIIVMMSLLVVNLYNIQV-NQ--YQDYKTRSNDNRIKVVPIapnRGLIYDRNGVLLAEN--RPV 86
Cdd:NF038278   2 KKKNASIPRRLNLLFFIIVLLFTVLILRLAQMQIlNKdfYTKKLAAATTYTVKTSSP---RGQIYDAKGKPLVENeiKQV 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501624753  87 F----NLEITPEKVK----------NMEDTLVRLQALID---------------IPPEriERFNRDRRN----------- 126
Cdd:NF038278  79 VsftrSNKMTAEEIKelaqklsqyvTVSEVKVTTRAKKDyyladpevyakvvekLPKK--KKYDSDGNRlteskiyanav 156

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501624753 127 -----------SRRFKSVPILNQ----------------LTEEQVAVFSVNQHKFPGVEVTGTLKRfYPYGDVLTHVIGY 179
Cdd:NF038278 157 dsvtdsqlnysDEELKVIYLFSQmnavanfntvnlktddLTAEQIAYIAANKSKLPGISVTTDWDR-KVLDTSLASIIGT 235

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501624753 180 VSRindrDMQRLVREEKDA----NYQATRDIGKLGIERYYEDMLHGTAGYQEVEVNSRGRVIRTLKFVPSAPGKDIVLNL 255
Cdd:NF038278 236 VSS----EEAGLPAEEADDylkkGYSLNDRVGTSYLEKQYESVLQGKREVKEIKLDKNGKIESDKITSEGQKGKNLKLTI 311

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501624753 256 DIKLQLYVHKLLDGRRGS--------------AVVLDPKDNGVLAMVsspsydpnafvhGISskgynallQDKDRPLVNR 321
Cdd:NF038278 312 DLDFQDGVEDILKKYFQSelasgnatysegvyAVALNPKTGAILAMA------------GLS--------HDLGTGNLTE 371

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501624753 322 ATLG----IYPPASTIKPFIAVAALQEGVITPNTTRND-PgywkIPNSKTKPFRDWL-RWGHGVVDIEKAIEESVDTFFY 395
Cdd:NF038278 372 DALGtitnVFTPGSVVKGATLTAGWENGVISGNQVLTDqP----IQFAGSAPITSWFtQYGSRPITAVQALEYSSNTYMV 447

                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501624753 396 QISFDL------------------GIDRLSKWMMLFGFGDYTGIDIYEESKANMPtREWKMArhrvpwyqgDTIPVGIGQ 457
Cdd:NF038278 448 QVALKMmgqdyhpgmtlttdglkeAMEKLRSTFAEYGLGVSTGIDLPGESTGYLP-KDYTVS---------NVLTEAFGQ 517

                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501624753 458 gYWTATPMQIAKATSVLVNEGEVTAPHLLRATIENgqpfDEQT-----ISEIETYPPVT-GVKQRYWDIAQEGMRLVNHG 531
Cdd:NF038278 518 -FDNYTPMQLAQYAATVANGGKRIAPHLVEGIYDN----NDNGglgdlVKTIETKVLNKvNISDEEMAIIQQGFYQVVNS 592

                        650       660       670       680       690       700       710
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 501624753 532 KKG-TARRSFQKMSYQTAGKSGTAQVFGLKED----EEYNADEIAehlrdhalftgYAPFEDPEAVVTIVL 597
Cdd:NF038278 593 SSGyATGRTLQGAAVTISAKTGTAETYVKDKNgqtvTTVNLNVVA-----------YAPSDNPQIAVAVVY 652
 
Name Accession Description Interval E-value
pbp2_mrdA TIGR03423
penicillin-binding protein 2; Members of this protein family are penicillin-binding protein 2 ...
 20-620 0e+00

penicillin-binding protein 2; Members of this protein family are penicillin-binding protein 2 (PBP-2), a protein whose gene (designated pbpA or mrdA) generally is found next to the gene for RodA, a protein required for rod (bacillus) shape in many bacteria. PBP-2 acts as a transpeptidase for cell elongation (hence, rod-shape). [Cell envelope, Biosynthesis and degradation of murein sacculus and peptidoglycan]


Pssm-ID: 274573 [Multi-domain]  Cd Length: 592  Bit Score: 911.91  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501624753   20 SRAFVAFAGIIVMMSLLVVNLYNIQVNQYQDYKTRSNDNRIKVVPIAPNRGLIYDRNGVLLAENRPVFNLEITPEKVKNM 99
Cdd:TIGR03423   1 RRALVLGGLVLALFGVLAARLFYLQVIRGEEYATLSEDNRIRLVPIPPPRGLILDRNGVLLADNRPSFSLEIVPEKVDDL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501624753  100 EDTLVRLQALIDIPPERIERFNRDRRNSRRFKSVPILNQLTEEQVAVFSVNQHKFPGVEVTGTLKRFYPYGDVLTHVIGY 179
Cdd:TIGR03423  81 DATLDRLAKLLDLDPEDIARFLKELKRSRRFEPIPLKSDLTEEEVARFAVNQYRLPGVEIEARLKRYYPYGELAAHVLGY 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501624753  180 VSRINDRDMQRLvreeKDANYQATRDIGKLGIERYYEDMLHGTAGYQEVEVNSRGRVIRTLKFVPSAPGKDIVLNLDIKL 259
Cdd:TIGR03423 161 VGEINEEDLERL----EPANYAGGDYIGKSGIEKYYEDELRGKPGYREVEVNARGRVIRTLSRVPPVPGKDLVLTIDARL 236

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501624753  260 QLYVHKLLDGRRGSAVVLDPKDNGVLAMVSSPSYDPNAFVHGISSKGYNALLQDKDRPLVNRATLGIYPPASTIKPFIAV 339
Cdd:TIGR03423 237 QQAAEKALGGRRGAVVVMDPRTGEILAMVSTPSFDPNLFVDGISSKDYKALLNDPDRPLLNRAIQGVYPPGSTFKPVVAL 316

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501624753  340 AALQEGVITPNTTRNDPGYWKIPNsktKPFRDWLRWGHGVVDIEKAIEESVDTFFYQISFDLGIDRLSKWMMLFGFGDYT 419
Cdd:TIGR03423 317 AALEEGVITPETRIYCPGYFQLGG---RRFRCWKRGGHGRVDLRKAIEESCDVYFYQLALRLGIDKIAEYAKRFGFGQKT 393

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501624753  420 GIDIYEESKANMPTREWKMARHRVPWYQGDTIPVGIGQGYWTATPMQIAKATSVLVNEGEVTAPHLLRATIENgqpfDEQ 499
Cdd:TIGR03423 394 GIDLPGEKSGLVPSREWKRKRFGQPWYPGDTLNVSIGQGYVLVTPLQLAVATAALANGGKLYKPHLVKSIEDP----DGG 469

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501624753  500 TISEIET-YPPVTGVKQRYWDIAQEGMRLVNHGKKGTARRSFQKMSYQTAGKSGTAQVFGLKEDEEYNADEIAEHLRDHA 578
Cdd:TIGR03423 470 VVRRTEPeVLRPLPISPENLDVVREGMRDVVNGPGGTARRARLGLPYKMAGKTGTAQVVSLKQGEKYDAEQIPERLRDHA 549

                         570       580       590       600
                  ....*....|....*....|....*....|....*....|..
gi 501624753  579 LFTGYAPFEDPEAVVTIVLENAGGGSSNGGPVVRRILDHIIL 620
Cdd:TIGR03423 550 LFVAFAPYDNPKIAVAVIVEHGGGGSSAAAPIARKIMDAYLL 591
PRK10795 PRK10795
penicillin-binding protein 2; Provisional
 1-629 0e+00

penicillin-binding protein 2; Provisional


Pssm-ID: 236761 [Multi-domain]  Cd Length: 634  Bit Score: 879.49  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501624753   1 MLRKRSQIRDYKAEARLFTSRAFVAFAGIIVMMSLLVVNLYNIQVNQYQDYKTRSNDNRIKVVPIAPNRGLIYDRNGVLL 80
Cdd:PRK10795   1 MKKLQNSFRDYTAESALFVRRALVAFLGILLLTGVLIANLYNLQIVRFTDYQTRSNENRIKLVPIAPSRGIIYDRNGTPL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501624753  81 AENRPVFNLEITPEKVKNMEDTLVRLQALIDIPPERIERFNRDRRNSRRFKSVPILNQLTEEQVAVFSVNQHKFPGVEVT 160
Cdd:PRK10795  81 ALNRTIYQLEMMPEKVDNLQQTLDALRSVVDLTDDDIAAFRKERARSRRFTSIPVKTNLTEVQVARFAVNQYRFPGVEVK 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501624753 161 GTLKRFYPYGDVLTHVIGYVSRINDRDMQRLVREEKDANYQATRDIGKLGIERYYEDMLHGTAGYQEVEVNSRGRVIRTL 240
Cdd:PRK10795 161 GYQRRYYPYGSALTHVIGYVSKINDKDVERLDKEGKLANYAATHDIGKLGIERYYEDVLHGKTGYEEVEVNNRGRVIRQL 240

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501624753 241 KFVPSAPGKDIVLNLDIKLQLYVHKLLDGRRGSAVVLDPKDNGVLAMVSSPSYDPNAFVHGISSKGYNALLQDKDRPLVN 320
Cdd:PRK10795 241 HEQPPQAGHDIYLTLDLKLQQYIETLLAGSRAAVVVTDPRTGGILALVSTPSYDPNLFVDGISSKDYSGLLNDPNRPLIN 320

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501624753 321 RATLGIYPPASTIKPFIAVAALQEGVITPNTTRNDPGYWKIPNSKtKPFRDWLRWGHGVVDIEKAIEESVDTFFYQISFD 400
Cdd:PRK10795 321 RATQGVYPPASTVKPYVAVSALSAGVITRNTSLFDPGWWQLPGSE-KRYRDWKKWGHGRLNVTKSLEESADTFFYQVAYD 399

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501624753 401 LGIDRLSKWMMLFGFGDYTGIDIYEESKANMPTREWKMARHRVPWYQGDTIPVGIGQGYWTATPMQIAKATSVLVNEGEV 480
Cdd:PRK10795 400 MGIDRLSEWMGKFGYGHYTGIDLAEERSGNMPTREWKQKRFKKPWYQGDTIPVGIGQGYWTATPIQMSKALMTLINDGIV 479

                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501624753 481 TAPHLLRATIENGQ--PFdEQTISeietyPPVTGVKQRYWDIAQEGMRLVNHGKKGTARRSFQKMSYQTAGKSGTAQVFG 558
Cdd:PRK10795 480 KVPHLLMSTAEDGKqvPW-VQPHE-----PPVGDIHSGYWEIAKDGMYGVANRPNGTAHKYFASAPYKIAAKSGTAQVFG 553

                        570       580       590       600       610       620       630
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 501624753 559 LKEDEEYNADEIAEHLRDHALFTGYAPFEDPEAVVTIVLENAGGGSSNGGpVVRRILDHIILAEDYESEPI 629
Cdd:PRK10795 554 LKANETYNAHKIAERLRDHKLMTAFAPYNNPQVAVAIILENGGAGPAVGT-IMRQILDHIMLGDNNTDLPA 623
FtsI COG0768
Cell division protein FtsI, peptidoglycan transpeptidase (Penicillin-binding protein 2) [Cell ...
 12-619 0e+00

Cell division protein FtsI, peptidoglycan transpeptidase (Penicillin-binding protein 2) [Cell cycle control, cell division, chromosome partitioning, Cell wall/membrane/envelope biogenesis];


Pssm-ID: 440531 [Multi-domain]  Cd Length: 568  Bit Score: 611.06  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501624753  12 KAEARLFTSRAFVAFAGIIVMMSLLVVNLYNIQVNQYQDYKTRSNDNRIKVVPIAPNRGLIYDRNGVLLAENRPVFNLEI 91
Cdd:COG0768    4 KKEKRLFRRRLLLLFLLVLLLFLLLVGRLFYLQVVEGDEYAELAEENRIRTVPIPAPRGLIYDRNGNVLATNVPVYSLYA 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501624753  92 TPEKVKNMEDTLVRLQALIDIPPERIERFNRDRRNSrrfkSVPILNQLTEEQVAVfsVNQHKFPGVEVTGTLKRFYPYGD 171
Cdd:COG0768   84 DPEEVKDPEETAEKLAKLLGLDPEELRKKLKKKSRF----PVYLKRNLSPEEAAR--IRALKLPGVYVEAEYKRYYPYGE 157

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501624753 172 VLTHVIGYVSRINDRDmqrlvreekdanyqatrDIGKLGIERYYEDMLHGTAGYQEVEVNSRGRVIRTL-KFVPSAPGKD 250
Cdd:COG0768  158 LAAHVLGYVGEINGGD-----------------GIGKSGLEKAYEDLLRGTPGKRRVEVDARGRVIRDLgEEKPPVPGKD 220

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501624753 251 IVLNLDIKLQLYVHKLLDG-------RRGSAVVLDPKDNGVLAMVSSPSYDPNAFVHGisskgynallqdKDRPLVNRAT 323
Cdd:COG0768  221 LVLTIDSDLQKIAEEALKKaveeykaKSGAVVVMDPKTGEILAMASYPSFDPNLFVGG------------PDEPLRNRAV 288

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501624753 324 LGIYPPASTIKPFIAVAALQEGVITPNTTRNDPGYWKIPNsktKPFRDWLRWGHGVVDIEKAIEESVDTFFYQISFDLGI 403
Cdd:COG0768  289 QGTYEPGSTFKPFTAAAALEEGVITPDTTFDCPGYYRVGG---RTIRDWDRGGHGTLTLTEALAKSSNVGFYKLALRLGI 365

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501624753 404 DRLSKWMMLFGFGDYTGIDIYEESKANMPTREwkmarhrvPWYQGDTIPVGIGQGyWTATPMQIAKATSVLVNEGEVTAP 483
Cdd:COG0768  366 DKLYDYLKKFGLGQKTGIDLPGEASGLLPSPK--------RWYPGETATMSIGQG-LSVTPLQLAQAYAAIANGGVLVKP 436

                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501624753 484 HLLRATIEngqPFDEQTISEIETYPPVtgVKQRYWDIAQEGMRLVNHGKKGTARRSfQKMSYQTAGKSGTAQVFGLKEDE 563
Cdd:COG0768  437 HLVKEIVD---PDGEVVKEEPEVLRRV--ISPETAETVREGMEGVVNEPGGTARRA-AIPGYRVAGKTGTAQVVDIGNGG 510

                        570       580       590       600       610
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 501624753 564 EYnadeiaeHLRDHALFTGYAPFEDPEAVVTIVLENAGGGS---SNGGPVVRRILDHII 619
Cdd:COG0768  511 YY-------KGRHIASFVGFAPADNPRYAVAVVVENPGGGAyggTVAAPVFREIMEAYL 562
Transpeptidase pfam00905
Penicillin binding protein transpeptidase domain; The active site serine (residue 337 in Swiss: ...
 272-616 3.98e-72

Penicillin binding protein transpeptidase domain; The active site serine (residue 337 in Swiss:P14677) is conserved in all members of this family.


Pssm-ID: 425939 [Multi-domain]  Cd Length: 296  Bit Score: 234.23  E-value: 3.98e-72
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501624753  272 GSAVVLDPKDNGVLAMVSSPSYDPNAFVhgisskgynallqdkdRPLVNRATLGIYPPASTIKPFIAVAALQEGVITPNT 351
Cdd:pfam00905   1 GSAVVLDPKTGEVLAMVGKPSYDPNGFI----------------GPLRNRAVTSRYEPGSTFKPFTALAALDNGVLKPDE 64

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501624753  352 TRNDPGYWKIPNsktKPFRDWLRWGHGVVDIEKAIEESVDTFFYQISFDLGIDRLSKWMMLFGFGDYTGIDIYEESkANM 431
Cdd:pfam00905  65 TIFDWPGKQQGG---KSIGDWNQDQVGIGTLRQALEYSSNWYMQKLAQKLGADKLRSYLKKFGYGNKTGIGLPGEN-AGY 140

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501624753  432 PTREwkmarhrvpWYQGDTIPVGIGqgyWTATPMQIAKATSVLVNEGEVTAPHLLRATIE-------NGQPFDEQTISEI 504
Cdd:pfam00905 141 LTPY---------WLEGATASFGIG---LTITPLQQAQAYAAIANGGKLVPPHLVKSIEDkvdpkvlNKLPISKSTAEKV 208

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501624753  505 etyppvtgvkqrywdiaQEGMRLVNHGKKGTARRsfQKMSYQTAGKSGTAQVFGLKEDEEYNAdeiaehlRDHALFTGYA 584
Cdd:pfam00905 209 -----------------KDMLRLVVNDGTGTGTA--AVPGYKVAGKTGTAQVAGPKGGGYYDG-------AQIGWFVGYA 262

                         330       340       350
                  ....*....|....*....|....*....|....
gi 501624753  585 PFEDPEAVVTIVLENAGGGS--SNGGPVVRRILD 616
Cdd:pfam00905 263 PADNPKYAFAVLIDDPKRYYggKVAAPIFKDILE 296
spoVD_pbp TIGR02214
stage V sporulation protein D; This model describes the spoVD subfamily of homologs of the ...
 29-598 1.86e-60

stage V sporulation protein D; This model describes the spoVD subfamily of homologs of the cell division protein FtsI, a penicillin binding protein. This subfamily is restricted to Bacillus subtilis and related Gram-positive species with known or suspected endospore formation capability. In these species, the functional equivalent of FtsI is desginated PBP-2B, a paralog of spoVD. [Cell envelope, Biosynthesis and degradation of murein sacculus and peptidoglycan, Cellular processes, Sporulation and germination]


Pssm-ID: 131269 [Multi-domain]  Cd Length: 636  Bit Score: 212.75  E-value: 1.86e-60
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501624753   29 IIVMMSLLVVNLYNIQVNQYQDYKTRSNDNRIKVVPIAPNRGLIYDRNGVLLAENRPVFNLEITPEKVKNMEDTLV---- 104
Cdd:TIGR02214   9 FTALFLILILRLFYVQVFRGSFYKEMAEDQWTREIPIEAKRGRILDRNGNELAVSVSVDRVDLDPATIRKNKEPKQreia 88

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501624753  105 -RLQALIDIPPERIerFNRDRRNSRRFKSVPILNQLTEE---QVAVFSVNqhkfpGVEVTGTLKRFYPYGDVLTHVIGYV 180
Cdd:TIGR02214  89 nELARVLEMDKEKV--FKRITKKNSPFVSAKLGRKIEKDkaeKVRNLKLN-----GVSVSPDSKRYYPNGDFLSHVLGFT 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501624753  181 SRINDrdmqrlvreekdanyqatrdiGKLGIERYYEDMLHGTAGYQEVEVNSRGRVIRTLK--FVPSAPGKDIVLNLDIK 258
Cdd:TIGR02214 162 NSDGR---------------------GLEGLELYYDKELRGLPGVRVAEYDANSLELPYAQhaYVKPVDGHDLVLTIDEN 220

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501624753  259 LQLYVHKLLD-------GRRGSAVVLDPKDNGVLAMVSSPSYDPNAFVHGisSKGYnallqdKDRplvNRATLGIYPPAS 331
Cdd:TIGR02214 221 IQYIIEREADkalrerkPKGVSIIVMNPKNGEILGMSNRPTYDPNDPRDK--SPDT------ARR---NRAVSDAYEPGS 289

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501624753  332 TIKPFIAVAALQEGVITPNTTRNDPGYWKIPNSKTKPfrdWLRWGHGVVDIEKAIEESVDTFFYQISFDLGIDRLSKWMM 411
Cdd:TIGR02214 290 TFKIITSSAAMEEGIVKESDKFYDDGSATVGGKKIKC---WKPGGHGSQTFPEVVQNSCNPGFIELGMRLGAEKLNNYIL 366

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501624753  412 LFGFGDYTGIDIYEESKANM-PTREWKMArhrvpwyqgDTIPVGIGQGYwTATPMQIAKATSVLVNEGEVTAPHLLRATI 490
Cdd:TIGR02214 367 AFGFGSKTGIDLPGEAAGILvPKKKVGPV---------DLATISFGQAN-TVTPIQLMTAVNAVANGGKLIQPHIMKEIS 436

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501624753  491 engqpfDEQTISEIETYPPVtgVKQRYWDiAQEGMR----LVNHGKKGTARRSFQKmSYQTAGKSGTAQvfGLKEDEEYN 566
Cdd:TIGR02214 437 ------DSQNNAVDQTFEPE--VKRQVVS-KETTQKlrlaLETVVSKGSGKNAFIE-GYRVGGKTGTAQ--KVKPNGGYM 504

                         570       580       590
                  ....*....|....*....|....*....|..
gi 501624753  567 ADEIAehlrdhALFTGYAPFEDPEAVVTIVLE 598
Cdd:TIGR02214 505 EGEYI------VSFVGFAPADDPAVAVLVVVD 530
PBP_dimer pfam03717
Penicillin-binding Protein dimerization domain; This domain is found at the N terminus of ...
 64-239 1.89e-55

Penicillin-binding Protein dimerization domain; This domain is found at the N terminus of Class B High Molecular Weight Penicillin-Binding Proteins. Its function has not been precisely defined, but is strongly implicated in PBP polymerization. The domain forms a largely disordered 'sugar tongs' structure.


Pssm-ID: 427460 [Multi-domain]  Cd Length: 178  Bit Score: 185.99  E-value: 1.89e-55
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501624753   64 PIAPNRGLIYDRNGVLLAENRPVFNLEITPEKVKNMED--TLVRLQALI----DIPPERIERFNRDRRNSRRFKSVPILN 137
Cdd:pfam03717   1 PIPAPRGEIYDRNGVVLATNKPVYSLTITPSKLKKADAlkTALKLAKLLsnyeDLDDEDLTERFLKMNSYKSYYPVVIKK 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501624753  138 QLTEEQVAVFSVNQHKFPGVEVTGTLKRFYPYGDVLTHVIGYVSRINDRDMQRLvreeKDANYQATRDIGKLGIERYYED 217
Cdd:pfam03717  81 NLSEEEVARIEENLLELPGVSIETDPVRYYPYGELAAHLLGYVGEITEEELEKY----LDKGYSRGDLVGKSGLEKQYES 156

                         170       180
                  ....*....|....*....|..
gi 501624753  218 MLHGTAGYQEVEVNSRGRVIRT 239
Cdd:pfam03717 157 VLRGKDGVRQVEVDALGRVIRE 178
PRK15105 PRK15105
peptidoglycan synthase FtsI; Provisional
 18-596 6.58e-32

peptidoglycan synthase FtsI; Provisional


Pssm-ID: 185060 [Multi-domain]  Cd Length: 578  Bit Score: 130.71  E-value: 6.58e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501624753  18 FTSRAFVAFAG-IIVMMSLLVVNLYNIQVNQyQDYKTRSNDNR-IKVVPIAPNRGLIYDRNGVLLAENRPVFNLEITPEK 95
Cdd:PRK15105  18 FISWRFALLCGcILLALVFLLGRVAWLQVIN-PDMLVREGDMRsLRVQEVSTSRGMITDRSGRPLAVSVPVKAIWADPKE 96

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501624753  96 VKN----MEDTlvRLQALID---IPPERI-ERFNRDRRNsrRFksVPILNQLTEEqVAVFsVNQHKFPGVEVTGTLKRFY 167
Cdd:PRK15105  97 VHDaggiSVDD--RWKALADalnIPLDQLsARINANPKG--RF--IYLARQVNPD-MADY-IKKLKLPGIHLREESRRYY 168

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501624753 168 PYGDVLTHVIGyVSRINDRDMQrlvreekdanyqatrdigklGIERYYEDMLHGTAGYQEVEVNSRGRVIRTLKFVPSAP 247
Cdd:PRK15105 169 PSGEVTAHLIG-FTNVDSQGIE--------------------GVEKSFDKWLTGQPGERIVRKDRYGRVIEDISSTDSQA 227

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501624753 248 GKDIVLNLDIKLQLYVHKLLD-------GRRGSAVVLDPKDNGVLAMVSSPSYDPNafvhgisskgyNALLQDKDrPLVN 320
Cdd:PRK15105 228 AHNLALSIDERLQALVYRELNnavafnkAESGSAVLVDVNTGEVLAMANSPSYNPN-----------NLSGTPKD-AMRN 295

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501624753 321 RATLGIYPPASTIKPFIAVAALQEGVITPNTTRNdpgywkipnskTKPFRdwlRWGHGVVDIEKAIEESVdTFFYQISFD 400
Cdd:PRK15105 296 RAITDVFEPGSTVKPMVVMTALQRGVVKENSVLN-----------TVPYR---INGHEIKDVARYSELTL-TGVLQKSSN 360

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501624753 401 LGIDRLSKWM---------MLFGFGDYTGIDIYEESKANMPTREwkmarhrvPWYQGDTIPVGIGQGYwTATPMQIAKat 471
Cdd:PRK15105 361 VGVSKLALAMpssalvdtySRFGLGKATNLGLVGERSGLYPQKQ--------RWSDIERATFSFGYGL-MVTPLQLAR-- 429

                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501624753 472 svlvnegevtaphlLRATIENGQPFDEQTISEIEtyPPVTGvkQRYWdiAQEGMRLVNH--------GKKGTarRSFQKm 543
Cdd:PRK15105 430 --------------VYATIGSYGIYRPLSITKVD--PPVPG--ERVF--PESIVRTVVHmmesvalpGGGGV--KAAIK- 486

                        570       580       590       600       610
                 ....*....|....*....|....*....|....*....|....*....|....
gi 501624753 544 SYQTAGKSGTAQVFGlkEDEEYnadeIAEHLrdhALFTGYAPFEDPE-AVVTIV 596
Cdd:PRK15105 487 GYRIAIKTGTAKKVG--PDGRY----INKYI---AYTAGVAPASQPRfALVVVI 531
strep_PBP2B NF038278
streptococcal penicillin-binding protein PBP2B;
12-597 2.41e-24

streptococcal penicillin-binding protein PBP2B;


Pssm-ID: 468446 [Multi-domain]  Cd Length: 678  Bit Score: 108.13  E-value: 2.41e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501624753  12 KAEARLFTSRAFVAFAGIIVMMSLLVVNLYNIQV-NQ--YQDYKTRSNDNRIKVVPIapnRGLIYDRNGVLLAEN--RPV 86
Cdd:NF038278   2 KKKNASIPRRLNLLFFIIVLLFTVLILRLAQMQIlNKdfYTKKLAAATTYTVKTSSP---RGQIYDAKGKPLVENeiKQV 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501624753  87 F----NLEITPEKVK----------NMEDTLVRLQALID---------------IPPEriERFNRDRRN----------- 126
Cdd:NF038278  79 VsftrSNKMTAEEIKelaqklsqyvTVSEVKVTTRAKKDyyladpevyakvvekLPKK--KKYDSDGNRlteskiyanav 156

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501624753 127 -----------SRRFKSVPILNQ----------------LTEEQVAVFSVNQHKFPGVEVTGTLKRfYPYGDVLTHVIGY 179
Cdd:NF038278 157 dsvtdsqlnysDEELKVIYLFSQmnavanfntvnlktddLTAEQIAYIAANKSKLPGISVTTDWDR-KVLDTSLASIIGT 235

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501624753 180 VSRindrDMQRLVREEKDA----NYQATRDIGKLGIERYYEDMLHGTAGYQEVEVNSRGRVIRTLKFVPSAPGKDIVLNL 255
Cdd:NF038278 236 VSS----EEAGLPAEEADDylkkGYSLNDRVGTSYLEKQYESVLQGKREVKEIKLDKNGKIESDKITSEGQKGKNLKLTI 311

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501624753 256 DIKLQLYVHKLLDGRRGS--------------AVVLDPKDNGVLAMVsspsydpnafvhGISskgynallQDKDRPLVNR 321
Cdd:NF038278 312 DLDFQDGVEDILKKYFQSelasgnatysegvyAVALNPKTGAILAMA------------GLS--------HDLGTGNLTE 371

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501624753 322 ATLG----IYPPASTIKPFIAVAALQEGVITPNTTRND-PgywkIPNSKTKPFRDWL-RWGHGVVDIEKAIEESVDTFFY 395
Cdd:NF038278 372 DALGtitnVFTPGSVVKGATLTAGWENGVISGNQVLTDqP----IQFAGSAPITSWFtQYGSRPITAVQALEYSSNTYMV 447

                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501624753 396 QISFDL------------------GIDRLSKWMMLFGFGDYTGIDIYEESKANMPtREWKMArhrvpwyqgDTIPVGIGQ 457
Cdd:NF038278 448 QVALKMmgqdyhpgmtlttdglkeAMEKLRSTFAEYGLGVSTGIDLPGESTGYLP-KDYTVS---------NVLTEAFGQ 517

                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501624753 458 gYWTATPMQIAKATSVLVNEGEVTAPHLLRATIENgqpfDEQT-----ISEIETYPPVT-GVKQRYWDIAQEGMRLVNHG 531
Cdd:NF038278 518 -FDNYTPMQLAQYAATVANGGKRIAPHLVEGIYDN----NDNGglgdlVKTIETKVLNKvNISDEEMAIIQQGFYQVVNS 592

                        650       660       670       680       690       700       710
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 501624753 532 KKG-TARRSFQKMSYQTAGKSGTAQVFGLKED----EEYNADEIAehlrdhalftgYAPFEDPEAVVTIVL 597
Cdd:NF038278 593 SSGyATGRTLQGAAVTISAKTGTAETYVKDKNgqtvTTVNLNVVA-----------YAPSDNPQIAVAVVY 652
MrcB COG0744
Penicillin-binding protein 1B/1F, peptidoglycan transglycosylase/transpeptidase [Cell wall ...
 225-585 1.09e-21

Penicillin-binding protein 1B/1F, peptidoglycan transglycosylase/transpeptidase [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 440507 [Multi-domain]  Cd Length: 630  Bit Score: 99.61  E-value: 1.09e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501624753 225 YQEVEVNSRGRVIRTlkfvpsapgkdivlNLDIKLQLYVHKLLDGR---------RGSAVVLDPKDNGVLAMVSSPSYDP 295
Cdd:COG0744  285 LGEDDLYRGGLKIYT--------------TLDPKLQKAAEKAVKNVlpegkpgglQAALVVVDPKTGEVLAMVGGRDYGK 350

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501624753 296 NAFvhgisskgynallqdkdrplvNRATLGIYPPASTIKPFIAVAALQEGvITPNTTRNDPGYwKIPNSKTKPfRDWLRW 375
Cdd:COG0744  351 SQF---------------------NRATQAKRQPGSTFKPFVYAAALEQG-YTPATTVDDEPV-TFPGGGWSP-KNYDGR 406

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501624753 376 GHGVVDIEKAIEESVDTFFYQISFDLGIDRLSKWMMLFGfgdytgidIYEESKANmptrewkmarhrvpwyqgdtIPVGI 455
Cdd:COG0744  407 YRGPVTLREALANSLNTPAVRLAQEVGLDKVVDTARRLG--------ITSPLDPN--------------------PSLAL 458

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501624753 456 GQGywTATPMQIAKATSVLVNEGEVTAPHLLRA-------TIENGQPFDEQTISEIETYppvtgvkqrywdIAQEGMRLV 528
Cdd:COG0744  459 GTS--EVSPLEMASAYATFANGGVYVEPHAITKvtdadgkVLYEAKPKCEQVISPEVAY------------LMTDMLQDV 524

                        330       340       350       360       370
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 501624753 529 NhgKKGTARRSfQKMSYQTAGKSGTAQvfglkedeeynadeiaeHLRDhALFTGYAP 585
Cdd:COG0744  525 V--TSGTGRAA-RLPGRPVAGKTGTTN-----------------DNRD-AWFVGYTP 560
PBP_1a_fam TIGR02074
penicillin-binding protein, 1A family; Bacterial that synthesize a cell wall of peptidoglycan ...
 247-585 2.55e-13

penicillin-binding protein, 1A family; Bacterial that synthesize a cell wall of peptidoglycan (murein) generally have several transglycosylases and transpeptidases for the task. This family consists of bifunctional transglycosylase/transpeptidase penicillin-binding proteins (PBP). In the Proteobacteria, this family includes PBP 1A but not the paralogous PBP 1B (TIGR02071). This family also includes related proteins, often designated PBP 1A, from other bacterial lineages. [Cell envelope, Biosynthesis and degradation of murein sacculus and peptidoglycan]


Pssm-ID: 273955 [Multi-domain]  Cd Length: 531  Bit Score: 72.68  E-value: 2.55e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501624753  247 PGKDIVLNLDIKLQLYVHKLLD------GRR------GSAVVLDPKDNGVLAMVSSPSYDPNAFvhgisskgynallqdk 314
Cdd:TIGR02074 220 GGLKIYTTLDLDAQKAAEKVLNtglrvaGRRdgddlqAALVAIDPDTGAVRALVGGRDYGKSQF---------------- 283

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501624753  315 drplvNRATLGIYPPASTIKPFIAVAALQEGViTPNTTRNDPGYWKIPNSKTKPfRDWLRWGHGVVDIEKAIEESVDTFF 394
Cdd:TIGR02074 284 -----NRATQAKRQPGSTFKPFVYAAALEKGL-TPATIVNDEPITYNGNGPWSP-KNYGGGYRGNVTLRQALAQSRNIPA 356

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501624753  395 YQISFDLGIDRLSKWMMLFGFgDYTGIDIYeeskanmptrewkmarhrvpwyqgdTIPVGIGQgywtATPMQIAKATSVL 474
Cdd:TIGR02074 357 VRLLQEVGLDKVVALAKRFGI-TSPLDPVL-------------------------SLALGTVE----VSPLEMASAYAVF 406

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501624753  475 VNEGEVTAPHLLRA-------TIENGQPFDEQTISEIETYPPV---TGVKQRywdiaqegmrlvnhgkkGTARRSfQKMS 544
Cdd:TIGR02074 407 ANGGKYVEPHGIRKivdrdgkVIYENKPKTTQVISPATAYIMTdmlKGVVES-----------------GTGRSA-RLPG 468

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|.
gi 501624753  545 YQTAGKSGTAQVFglkedeeynadeiaehlRDhALFTGYAP 585
Cdd:TIGR02074 469 RPVAGKTGTTQNW-----------------RD-AWFVGYTP 491
MrcA COG5009
Membrane carboxypeptidase/penicillin-binding protein [Cell wall/membrane/envelope biogenesis];
272-553 2.06e-08

Membrane carboxypeptidase/penicillin-binding protein [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 444033 [Multi-domain]  Cd Length: 785  Bit Score: 57.48  E-value: 2.06e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501624753 272 GSAVVLDPKDNGVLAMVSSPSYDPNAFvhgisskgynallqdkdrplvNRATLGIYPPASTIKPFIAVAALQEGvITPNT 351
Cdd:COG5009  423 GALVALDPHTGAVLALVGGFDFEQSKF---------------------NRATQAKRQPGSSFKPFVYAAALDNG-YTPAT 480

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501624753 352 TRND-P---------GYWKIPNSKTK---PFRdwLRWghgvvdiekAIEESVDTFFYQISFDLGIDRLSKWMMLFGFGDy 418
Cdd:COG5009  481 IINDaPivfddggggGVWRPKNYSGKfygPTT--LRE---------ALEKSRNLVTVRLLQDVGIDYVIDYAERFGIYS- 548

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501624753 419 tgidiyeeskaNMPtrewkmarhRVPwyqgdtiPVGIGQGywTATPMQIAKATSVLVNEGEVTAPHLLRaTIENGQ---- 494
Cdd:COG5009  549 -----------KLP---------PNL-------SLALGSG--EVTPLEMARAYAVFANGGYRVEPYLID-RIEDRNgkvi 598

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501624753 495 -PFDEQTISEIETYPPVTGVKQRYWDIAQEGMR-----LVNH---G--KKGTARRSfQKMSYQTAGKSGT 553
Cdd:COG5009  599 yRADPARACEDCDAAEWDGAEPRLPDPAEQVIDprtayQMTSmlrGvvQRGTGRRA-RALGRDIAGKTGT 667
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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