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Conserved domains on  [gi|501626460|ref|WP_012604166|]
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MULTISPECIES: Lrp/AsnC family transcriptional regulator [Vibrio]

Protein Classification

Lrp/AsnC family transcriptional regulator( domain architecture ID 11445815)

Lrp/AsnC (leucine-responsive regulatory protein/asparagine synthase C) family transcriptional regulator regulates many cellular processes such as amino acid metabolism, pili synthesis, and DNA repair and recombination

CATH:  3.30.70.920|1.10.10.10
Gene Ontology:  GO:0043565
PubMed:  16438681|21608015|27206730

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Lrp COG1522
DNA-binding transcriptional regulator, Lrp family [Transcription];
1-139 4.61e-58

DNA-binding transcriptional regulator, Lrp family [Transcription];


:

Pssm-ID: 441131 [Multi-domain]  Cd Length: 138  Bit Score: 176.89  E-value: 4.61e-58
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501626460   1 MDEIDKKILAELQSNARLTNQELADRVALSPSPCLRRVRALEKQGIIRGYHASVDQEACGLPVNVFVLVKLEkptEENMR 80
Cdd:COG1522    3 LDEIDRRILRLLQEDGRLSFAELAERVGLSESTVLRRVRRLEEAGVIRGYGAVVDPEKLGLGVTAFVEVKVP---PHRLD 79

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 501626460  81 DFEQHIEVIDEVLECFLMTGNHDYLLHVVSESLKSYEQFIRKQLTRLPNIASIESSFAF 139
Cdd:COG1522   80 EFAEALAAIPEVLECYLVTGDYDLLLKVVARDMEELERFLLERLAALPGVRRTETSFVL 138
 
Name Accession Description Interval E-value
Lrp COG1522
DNA-binding transcriptional regulator, Lrp family [Transcription];
1-139 4.61e-58

DNA-binding transcriptional regulator, Lrp family [Transcription];


Pssm-ID: 441131 [Multi-domain]  Cd Length: 138  Bit Score: 176.89  E-value: 4.61e-58
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501626460   1 MDEIDKKILAELQSNARLTNQELADRVALSPSPCLRRVRALEKQGIIRGYHASVDQEACGLPVNVFVLVKLEkptEENMR 80
Cdd:COG1522    3 LDEIDRRILRLLQEDGRLSFAELAERVGLSESTVLRRVRRLEEAGVIRGYGAVVDPEKLGLGVTAFVEVKVP---PHRLD 79

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 501626460  81 DFEQHIEVIDEVLECFLMTGNHDYLLHVVSESLKSYEQFIRKQLTRLPNIASIESSFAF 139
Cdd:COG1522   80 EFAEALAAIPEVLECYLVTGDYDLLLKVVARDMEELERFLLERLAALPGVRRTETSFVL 138
HTH_ASNC smart00344
helix_turn_helix ASNC type; AsnC: an autogenously regulated activator of asparagine synthetase ...
 1-109 9.90e-43

helix_turn_helix ASNC type; AsnC: an autogenously regulated activator of asparagine synthetase A transcription in Escherichia coli)


Pssm-ID: 214628 [Multi-domain]  Cd Length: 108  Bit Score: 137.26  E-value: 9.90e-43
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501626460     1 MDEIDKKILAELQSNARLTNQELADRVALSPSPCLRRVRALEKQGIIRGYHASVDQEACGLPVNVFVLVKLEKPteENMR 80
Cdd:smart00344   1 LDEIDRKILEELQKDARISLAELAKKVGLSPSTVHNRVKRLEEEGVIKGYTAVLNPKKLGLSVTAFVGVTLENP--DKLE 78

                           90       100
                   ....*....|....*....|....*....
gi 501626460    81 DFEQHIEVIDEVLECFLMTGNHDYLLHVV 109
Cdd:smart00344  79 EFLEKLEKLPEVEEVYLVTGDYDYLLKVR 107
PRK11169 PRK11169
leucine-responsive transcriptional regulator Lrp;
1-148 4.25e-35

leucine-responsive transcriptional regulator Lrp;


Pssm-ID: 183009 [Multi-domain]  Cd Length: 164  Bit Score: 119.48  E-value: 4.25e-35
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501626460   1 MDEIDKKILAELQSNARLTNQELADRVALSPSPCLRRVRALEKQGIIRGYHASVDQEACGLPVNVFVLVKLEKPTEENMR 80
Cdd:PRK11169  12 LDRIDRNILNELQKDGRISNVELSKRVGLSPTPCLERVRRLERQGFIQGYTALLNPHYLDASLLVFVEITLNRGAPDVFE 91

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 501626460  81 DFEQHIEVIDEVLECFLMTGNHDYLLHVVSESLKSYEQFIRKQLTRLPNIASIESSFAFGQVKTKTKL 148
Cdd:PRK11169  92 QFNAAVQKLEEIQECHLVSGDFDYLLKTRVPDMSAYRKLLGETLLRLPGVNDTRTYVVMEEVKQTNRL 159
AsnC_trans_reg pfam01037
Lrp/AsnC ligand binding domain; The l-leucine-responsive regulatory protein (Lrp/AsnC) family ...
 67-141 3.02e-20

Lrp/AsnC ligand binding domain; The l-leucine-responsive regulatory protein (Lrp/AsnC) family is a family of similar bacterial transcription regulatory proteins. The family is named after two E. coli proteins involved in regulating amino acid metabolism. This entry corresponds to the usually C-terminal regulatory ligand binding domain. Structurally this domain has a dimeric alpha/beta barrel fold. This domain binds almost exclusively amino acids but also 4-hydroxyphenylpyruvate and kynurenine (Matilla et. al., FEMS Microbiology Reviews, fuab043, 45, 2021, 1. https://doi.org/10.1093/femsre/fuab043).


Pssm-ID: 426007  Cd Length: 73  Bit Score: 78.72  E-value: 3.02e-20
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 501626460   67 VLVKLEKPteENMRDFEQHIEVIDEVLECFLMTGNHDYLLHVVSESLKSYEQFIRKQLTRLPNIASIESSFAFGQ 141
Cdd:pfam01037   1 VEVKLEPG--HALEEFAEALAAIPEVVECYRVTGDYDYLLKVVARDLEALERFLREKLRSLPGVARTETSIVLST 73
HTH_ARSR cd00090
Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric ...
 2-50 6.14e-07

Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to dissociate from DNA in the presence of metal ions.


Pssm-ID: 238042 [Multi-domain]  Cd Length: 78  Bit Score: 44.60  E-value: 6.14e-07
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*....
gi 501626460   2 DEIDKKILAELQSNaRLTNQELADRVALSPSPCLRRVRALEKQGIIRGY 50
Cdd:cd00090    6 DPTRLRILRLLLEG-PLTVSELAERLGLSQSTVSRHLKKLEEAGLVESR 53
 
Name Accession Description Interval E-value
Lrp COG1522
DNA-binding transcriptional regulator, Lrp family [Transcription];
1-139 4.61e-58

DNA-binding transcriptional regulator, Lrp family [Transcription];


Pssm-ID: 441131 [Multi-domain]  Cd Length: 138  Bit Score: 176.89  E-value: 4.61e-58
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501626460   1 MDEIDKKILAELQSNARLTNQELADRVALSPSPCLRRVRALEKQGIIRGYHASVDQEACGLPVNVFVLVKLEkptEENMR 80
Cdd:COG1522    3 LDEIDRRILRLLQEDGRLSFAELAERVGLSESTVLRRVRRLEEAGVIRGYGAVVDPEKLGLGVTAFVEVKVP---PHRLD 79

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 501626460  81 DFEQHIEVIDEVLECFLMTGNHDYLLHVVSESLKSYEQFIRKQLTRLPNIASIESSFAF 139
Cdd:COG1522   80 EFAEALAAIPEVLECYLVTGDYDLLLKVVARDMEELERFLLERLAALPGVRRTETSFVL 138
HTH_ASNC smart00344
helix_turn_helix ASNC type; AsnC: an autogenously regulated activator of asparagine synthetase ...
 1-109 9.90e-43

helix_turn_helix ASNC type; AsnC: an autogenously regulated activator of asparagine synthetase A transcription in Escherichia coli)


Pssm-ID: 214628 [Multi-domain]  Cd Length: 108  Bit Score: 137.26  E-value: 9.90e-43
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501626460     1 MDEIDKKILAELQSNARLTNQELADRVALSPSPCLRRVRALEKQGIIRGYHASVDQEACGLPVNVFVLVKLEKPteENMR 80
Cdd:smart00344   1 LDEIDRKILEELQKDARISLAELAKKVGLSPSTVHNRVKRLEEEGVIKGYTAVLNPKKLGLSVTAFVGVTLENP--DKLE 78

                           90       100
                   ....*....|....*....|....*....
gi 501626460    81 DFEQHIEVIDEVLECFLMTGNHDYLLHVV 109
Cdd:smart00344  79 EFLEKLEKLPEVEEVYLVTGDYDYLLKVR 107
PRK11169 PRK11169
leucine-responsive transcriptional regulator Lrp;
1-148 4.25e-35

leucine-responsive transcriptional regulator Lrp;


Pssm-ID: 183009 [Multi-domain]  Cd Length: 164  Bit Score: 119.48  E-value: 4.25e-35
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501626460   1 MDEIDKKILAELQSNARLTNQELADRVALSPSPCLRRVRALEKQGIIRGYHASVDQEACGLPVNVFVLVKLEKPTEENMR 80
Cdd:PRK11169  12 LDRIDRNILNELQKDGRISNVELSKRVGLSPTPCLERVRRLERQGFIQGYTALLNPHYLDASLLVFVEITLNRGAPDVFE 91

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 501626460  81 DFEQHIEVIDEVLECFLMTGNHDYLLHVVSESLKSYEQFIRKQLTRLPNIASIESSFAFGQVKTKTKL 148
Cdd:PRK11169  92 QFNAAVQKLEEIQECHLVSGDFDYLLKTRVPDMSAYRKLLGETLLRLPGVNDTRTYVVMEEVKQTNRL 159
AsnC_trans_reg pfam01037
Lrp/AsnC ligand binding domain; The l-leucine-responsive regulatory protein (Lrp/AsnC) family ...
 67-141 3.02e-20

Lrp/AsnC ligand binding domain; The l-leucine-responsive regulatory protein (Lrp/AsnC) family is a family of similar bacterial transcription regulatory proteins. The family is named after two E. coli proteins involved in regulating amino acid metabolism. This entry corresponds to the usually C-terminal regulatory ligand binding domain. Structurally this domain has a dimeric alpha/beta barrel fold. This domain binds almost exclusively amino acids but also 4-hydroxyphenylpyruvate and kynurenine (Matilla et. al., FEMS Microbiology Reviews, fuab043, 45, 2021, 1. https://doi.org/10.1093/femsre/fuab043).


Pssm-ID: 426007  Cd Length: 73  Bit Score: 78.72  E-value: 3.02e-20
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 501626460   67 VLVKLEKPteENMRDFEQHIEVIDEVLECFLMTGNHDYLLHVVSESLKSYEQFIRKQLTRLPNIASIESSFAFGQ 141
Cdd:pfam01037   1 VEVKLEPG--HALEEFAEALAAIPEVVECYRVTGDYDYLLKVVARDLEALERFLREKLRSLPGVARTETSIVLST 73
HTH_24 pfam13412
Winged helix-turn-helix DNA-binding;
3-47 3.60e-17

Winged helix-turn-helix DNA-binding;


Pssm-ID: 404317 [Multi-domain]  Cd Length: 45  Bit Score: 70.16  E-value: 3.60e-17
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 501626460    3 EIDKKILAELQSNARLTNQELADRVALSPSPCLRRVRALEKQGII 47
Cdd:pfam13412   1 ETDRKILNLLQENPRISQRELAERLGLSPSTVNRRLKRLEEEGVI 45
HTH_AsnC-type pfam13404
AsnC-type helix-turn-helix domain;
2-42 4.04e-17

AsnC-type helix-turn-helix domain;


Pssm-ID: 433180 [Multi-domain]  Cd Length: 41  Bit Score: 70.09  E-value: 4.04e-17
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 501626460    2 DEIDKKILAELQSNARLTNQELADRVALSPSPCLRRVRALE 42
Cdd:pfam13404   1 DEIDRKILRLLQEDARISFAELAERVGLSESTVLRRIRRLE 41
PRK11179 PRK11179
DNA-binding transcriptional regulator AsnC; Provisional
 1-136 1.05e-12

DNA-binding transcriptional regulator AsnC; Provisional


Pssm-ID: 183019 [Multi-domain]  Cd Length: 153  Bit Score: 61.65  E-value: 1.05e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501626460   1 MDEIDKKILAELQSNARLTNQELADRVALSPSPCLRRVRALEKQGIIRGYHASVDQEACGLPVNVFVLVKLekpteENMR 80
Cdd:PRK11179   7 IDNLDRGILEALMENARTPYAELAKQFGVSPGTIHVRVEKMKQAGIITGTRVDVNPKQLGYDVCCFIGIIL-----KSAK 81

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 501626460  81 DFEQHI---EVIDEVLECFLMTGNHDYLLHVVSESLKSYEQFIrkqLTRLPNIASIESS 136
Cdd:PRK11179  82 DYPSALaklESLDEVVEAYYTTGHYSIFIKVMCRSIDALQHVL---INKIQTIDEIQST 137
HTH_ARSR cd00090
Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric ...
 2-50 6.14e-07

Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to dissociate from DNA in the presence of metal ions.


Pssm-ID: 238042 [Multi-domain]  Cd Length: 78  Bit Score: 44.60  E-value: 6.14e-07
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*....
gi 501626460   2 DEIDKKILAELQSNaRLTNQELADRVALSPSPCLRRVRALEKQGIIRGY 50
Cdd:cd00090    6 DPTRLRILRLLLEG-PLTVSELAERLGLSQSTVSRHLKKLEEAGLVESR 53
COG3398 COG3398
Predicted transcriptional regulator, contains two HTH domains [Transcription];
3-48 1.62e-03

Predicted transcriptional regulator, contains two HTH domains [Transcription];


Pssm-ID: 442625 [Multi-domain]  Cd Length: 159  Bit Score: 36.78  E-value: 1.62e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*.
gi 501626460   3 EIDKKILAELQSNARLTNQELADRVALSPSPCLRRVRALEKQGIIR 48
Cdd:COG3398   97 ETPRRILLYLLENPGATNKELAEELGISRSTVSWHLKRLEEDGLVE 142
HTH_20 pfam12840
Helix-turn-helix domain; This domain represents a DNA-binding Helix-turn-helix domain found in ...
 7-48 4.09e-03

Helix-turn-helix domain; This domain represents a DNA-binding Helix-turn-helix domain found in transcriptional regulatory proteins.


Pssm-ID: 432824 [Multi-domain]  Cd Length: 61  Bit Score: 34.05  E-value: 4.09e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 501626460    7 KILAELQSNARLTNQELADRVALSPSPCLRRVRALEKQGIIR 48
Cdd:pfam12840  14 RILRALVGDEPLTASELARRLDISRNTLSYHLRKLEEAGLVE 55
COG2512 COG2512
Predicted transcriptional regulator, contains CW (cell wall-binding) repeats and an HTH domain ...
 1-48 9.71e-03

Predicted transcriptional regulator, contains CW (cell wall-binding) repeats and an HTH domain [General function prediction only];


Pssm-ID: 442002 [Multi-domain]  Cd Length: 80  Bit Score: 33.35  E-value: 9.71e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*....
gi 501626460   1 MDEIDKKILAELQSNA-RLTNQELADRVALSPSPCLRRVRALEKQGIIR 48
Cdd:COG2512   13 LLEDERRVLELLRENGgRMTQSEIVKETGWSKSKVSRLLSRLEERGLIE 61
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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