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Conserved domains on  [gi|501696293|ref|WP_012619523|]
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ornithine carbamoyltransferase [Buchnera aphidicola]

Protein Classification

ornithine carbamoyltransferase( domain architecture ID 11479962)

ornithine carbamoyltransferase reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to L-ornithine (ORN) to produce L-citrulline, as part of the urea cycle and L-arginine biosynthesis

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PRK03515 PRK03515
ornithine carbamoyltransferase subunit I; Provisional
 1-336 0e+00

ornithine carbamoyltransferase subunit I; Provisional


:

Pssm-ID: 179587 [Multi-domain]  Cd Length: 336  Bit Score: 674.89  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501696293   1 MNNLYQRDCLRLLDFTSLELQNIITLAQKLKQYKKNNKEIQLLKKKNIALIFEKESTRTRCSFEVAAFDQGAHVTYLGPG 80
Cdd:PRK03515   1 MNQFYQRHFLRLLDFTPAELNSLLQLAAKLKADKKNGKEEQKLTGKNIALIFEKDSTRTRCSFEVAAYDQGARVTYLGPS 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501696293  81 STHLGTKESIEDTAKILGRLYDGIQYRGHHHSTIEILAKNSKVPVWNGLTEKFHPTQLLADLLTIKEIFPERKFYEIKCA 160
Cdd:PRK03515  81 GSQIGHKESIKDTARVLGRMYDGIQYRGYGQEIVETLAEYAGVPVWNGLTNEFHPTQLLADLLTMQEHLPGKAFNEMTLA 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501696293 161 YVGDAHNNMGNSLLEAASLVGLDLRLVAPKECWPEKNIFKFCKEQIKNKKGNIICTENINEGVKNVDFIYTDVWVSMGES 240
Cdd:PRK03515 161 YAGDARNNMGNSLLEAAALTGLDLRLVAPKACWPEAALVTECRALAQKNGGNITLTEDIAEGVKGADFIYTDVWVSMGEP 240

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501696293 241 QEVWKKRIELLSSYQVNSLMLKITNNPQVKVLHCLPALHDQKTCTVKSILKKYGFKNGMEITDEVFQKNQKIIFEQAENR 320
Cdd:PRK03515 241 KEVWAERIALLRPYQVNSKMMQLTGNPQVKFLHCLPAFHDDQTTLGKKMAEEYGLHGGMEVTDEVFESAHSIVFDQAENR 320

                        330
                 ....*....|....*.
gi 501696293 321 LHTIKAILVSSLLKTI 336
Cdd:PRK03515 321 LHTIKAVMVATLSKDL 336
 
Name Accession Description Interval E-value
PRK03515 PRK03515
ornithine carbamoyltransferase subunit I; Provisional
 1-336 0e+00

ornithine carbamoyltransferase subunit I; Provisional


Pssm-ID: 179587 [Multi-domain]  Cd Length: 336  Bit Score: 674.89  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501696293   1 MNNLYQRDCLRLLDFTSLELQNIITLAQKLKQYKKNNKEIQLLKKKNIALIFEKESTRTRCSFEVAAFDQGAHVTYLGPG 80
Cdd:PRK03515   1 MNQFYQRHFLRLLDFTPAELNSLLQLAAKLKADKKNGKEEQKLTGKNIALIFEKDSTRTRCSFEVAAYDQGARVTYLGPS 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501696293  81 STHLGTKESIEDTAKILGRLYDGIQYRGHHHSTIEILAKNSKVPVWNGLTEKFHPTQLLADLLTIKEIFPERKFYEIKCA 160
Cdd:PRK03515  81 GSQIGHKESIKDTARVLGRMYDGIQYRGYGQEIVETLAEYAGVPVWNGLTNEFHPTQLLADLLTMQEHLPGKAFNEMTLA 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501696293 161 YVGDAHNNMGNSLLEAASLVGLDLRLVAPKECWPEKNIFKFCKEQIKNKKGNIICTENINEGVKNVDFIYTDVWVSMGES 240
Cdd:PRK03515 161 YAGDARNNMGNSLLEAAALTGLDLRLVAPKACWPEAALVTECRALAQKNGGNITLTEDIAEGVKGADFIYTDVWVSMGEP 240

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501696293 241 QEVWKKRIELLSSYQVNSLMLKITNNPQVKVLHCLPALHDQKTCTVKSILKKYGFKNGMEITDEVFQKNQKIIFEQAENR 320
Cdd:PRK03515 241 KEVWAERIALLRPYQVNSKMMQLTGNPQVKFLHCLPAFHDDQTTLGKKMAEEYGLHGGMEVTDEVFESAHSIVFDQAENR 320

                        330
                 ....*....|....*.
gi 501696293 321 LHTIKAILVSSLLKTI 336
Cdd:PRK03515 321 LHTIKAVMVATLSKDL 336
ArgF COG0078
Ornithine carbamoyltransferase [Amino acid transport and metabolism]; Ornithine ...
 2-334 1.23e-160

Ornithine carbamoyltransferase [Amino acid transport and metabolism]; Ornithine carbamoyltransferase is part of the Pathway/BioSystem: Arginine biosynthesis


Pssm-ID: 439848 [Multi-domain]  Cd Length: 310  Bit Score: 451.04  E-value: 1.23e-160
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501696293   2 NNLYQRDCLRLLDFTSLELQNIITLAQKLKQYKKNNKEIQLLKKKNIALIFEKESTRTRCSFEVAAFDQGAHVTYLGPGS 81
Cdd:COG0078    1 TNLKGRHFLSLLDLTPEELRALLDLAAELKAKRKAGIPHRPLKGKTLAMIFEKPSTRTRVSFEVGMAQLGGHAIYLDPGD 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501696293  82 THLGTKESIEDTAKILGRLYDGIQYRGHHHSTIEILAKNSKVPVWNGLTEKFHPTQLLADLLTIKEIFPerKFYEIKCAY 161
Cdd:COG0078   81 SQLGRGESIKDTARVLSRYVDGIMIRTFGHETLEELAKYAGVPVINGLTDLFHPCQALADLLTIREHFG--KLKGLKVAY 158

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501696293 162 VGDAhNNMGNSLLEAASLVGLDLRLVAPKECWPEKNIFKFCKEQIKNKKGNIICTENINEGVKNVDFIYTDVWVSMGESQ 241
Cdd:COG0078  159 VGDG-NNVANSLLLAAAKLGMDVRIATPEGYEPDPEIVAKAKEIAAESGGSITITHDPAEAVKGADVVYTDVWVSMGQEE 237

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501696293 242 EVwKKRIELLSSYQVNSLMLKITnNPQVKVLHCLPALHdqktctvksilkkygfknGMEITDEVFQKNQKIIFEQAENRL 321
Cdd:COG0078  238 EA-EERIKAFKPYQVNEELMALA-KPDAIFMHCLPAHR------------------GEEVTDEVIDGPQSVVFDEAENRL 297

                        330
                 ....*....|...
gi 501696293 322 HTIKAILVSSLLK 334
Cdd:COG0078  298 HAQKALLAWLLGG 310
orni_carb_tr TIGR00658
ornithine carbamoyltransferase; This family of ornithine carbamoyltransferases (OTCase) is in ...
 7-332 1.16e-144

ornithine carbamoyltransferase; This family of ornithine carbamoyltransferases (OTCase) is in a superfamily with the related enzyme aspartate carbamoyltransferase. Most known examples are anabolic, playing a role in arginine biosynthesis, but some are catabolic. Most OTCases are homotrimers, but the homotrimers are organized into dodecamers built from four trimers in at least two species; the catabolic OTCase of Pseudomonas aeruginosa is allosterically regulated, while OTCase of the extreme thermophile Pyrococcus furiosus shows both allostery and thermophily. [Amino acid biosynthesis, Glutamate family]


Pssm-ID: 129743 [Multi-domain]  Cd Length: 304  Bit Score: 410.59  E-value: 1.16e-144
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501696293    7 RDCLRLLDFTSLELQNIITLAQKLKQYKKNNKEIQLLKKKNIALIFEKESTRTRCSFEVAAFDQGAHVTYLGPGSTHLGT 86
Cdd:TIGR00658   1 RHLLSLLDLSPEEIRYLLQLAKKLKKGKKKGKEHKKLKGKTLALIFEKPSTRTRVSFEVAAYQLGGHPLYLNPNDLQLGR 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501696293   87 KESIEDTAKILGRLYDGIQYRGHHHSTIEILAKNSKVPVWNGLTEKFHPTQLLADLLTIKEIFPerKFYEIKCAYVGDAh 166
Cdd:TIGR00658  81 GESIKDTARVLSRYVDGIMARVYKHEDVEELAKYASVPVINGLTDLFHPCQALADLLTIIEHFG--KLKGVKVVYVGDG- 157

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501696293  167 NNMGNSLLEAASLVGLDLRLVAPKECWPEKNIFKFCKEQIKNKKGNIICTENINEGVKNVDFIYTDVWVSMGESQEvWKK 246
Cdd:TIGR00658 158 NNVCNSLMLAGAKLGMDVVVATPEGYEPDADIVKKAQEIAKENGGSVELTHDPVEAVKGADVIYTDVWVSMGEEDK-KEE 236

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501696293  247 RIELLSSYQVNSLMLKITnNPQVKVLHCLPALHdqktctvksilkkygfknGMEITDEVFQKNQKIIFEQAENRLHTIKA 326
Cdd:TIGR00658 237 RLKLFRPYQVNEELMELA-KPEVIFMHCLPAHR------------------GEEVTDEVIEGPHSIVFDQAENRLHAQKA 297


                  ....*.
gi 501696293  327 ILVSSL 332
Cdd:TIGR00658 298 VMVALL 303
OTCace_N pfam02729
Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain;
8-147 4.79e-65

Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain;


Pssm-ID: 460665 [Multi-domain]  Cd Length: 140  Bit Score: 201.89  E-value: 4.79e-65
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501696293    8 DCLRLLDFTSLELQNIITLAQKLKQYKKNNKEIQLLKKKNIALIFEKESTRTRCSFEVAAFDQGAHVTYLGPGSTHLGTK 87
Cdd:pfam02729   1 HFLSLEDLSREEIEALLDLAAELKEARKRGKKLPLLKGKTVALLFEEPSTRTRVSFEVAAKRLGGHVIYLSSSDIQLSSG 80

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 501696293   88 ESIEDTAKILGRLYDGIQYRGHHHSTIEILAKNSKVPVWNGLTEKFHPTQLLADLLTIKE 147
Cdd:pfam02729  81 ESLADTARVLSRYVDAIVIRHFGHEDLEELAEYASVPVINAGGDHEHPTQALADLLTIRE 140
 
Name Accession Description Interval E-value
PRK03515 PRK03515
ornithine carbamoyltransferase subunit I; Provisional
 1-336 0e+00

ornithine carbamoyltransferase subunit I; Provisional


Pssm-ID: 179587 [Multi-domain]  Cd Length: 336  Bit Score: 674.89  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501696293   1 MNNLYQRDCLRLLDFTSLELQNIITLAQKLKQYKKNNKEIQLLKKKNIALIFEKESTRTRCSFEVAAFDQGAHVTYLGPG 80
Cdd:PRK03515   1 MNQFYQRHFLRLLDFTPAELNSLLQLAAKLKADKKNGKEEQKLTGKNIALIFEKDSTRTRCSFEVAAYDQGARVTYLGPS 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501696293  81 STHLGTKESIEDTAKILGRLYDGIQYRGHHHSTIEILAKNSKVPVWNGLTEKFHPTQLLADLLTIKEIFPERKFYEIKCA 160
Cdd:PRK03515  81 GSQIGHKESIKDTARVLGRMYDGIQYRGYGQEIVETLAEYAGVPVWNGLTNEFHPTQLLADLLTMQEHLPGKAFNEMTLA 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501696293 161 YVGDAHNNMGNSLLEAASLVGLDLRLVAPKECWPEKNIFKFCKEQIKNKKGNIICTENINEGVKNVDFIYTDVWVSMGES 240
Cdd:PRK03515 161 YAGDARNNMGNSLLEAAALTGLDLRLVAPKACWPEAALVTECRALAQKNGGNITLTEDIAEGVKGADFIYTDVWVSMGEP 240

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501696293 241 QEVWKKRIELLSSYQVNSLMLKITNNPQVKVLHCLPALHDQKTCTVKSILKKYGFKNGMEITDEVFQKNQKIIFEQAENR 320
Cdd:PRK03515 241 KEVWAERIALLRPYQVNSKMMQLTGNPQVKFLHCLPAFHDDQTTLGKKMAEEYGLHGGMEVTDEVFESAHSIVFDQAENR 320

                        330
                 ....*....|....*.
gi 501696293 321 LHTIKAILVSSLLKTI 336
Cdd:PRK03515 321 LHTIKAVMVATLSKDL 336
PRK02102 PRK02102
ornithine carbamoyltransferase; Validated
 3-332 0e+00

ornithine carbamoyltransferase; Validated


Pssm-ID: 179366 [Multi-domain]  Cd Length: 331  Bit Score: 512.51  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501696293   3 NLYQRDCLRLLDFTSLELQNIITLAQKLKQYKKNNKEIQLLKKKNIALIFEKESTRTRCSFEVAAFDQGAHVTYLGPGST 82
Cdd:PRK02102   4 NLKGRSFLKLLDFTPEEIEYLIDLSIELKAAKKAGIEHQYLEGKNIALIFEKTSTRTRCAFEVAAIDLGAHVTYLGPNDS 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501696293  83 HLGTKESIEDTAKILGRLYDGIQYRGHHHSTIEILAKNSKVPVWNGLTEKFHPTQLLADLLTIKEIFpeRKFYEIKCAYV 162
Cdd:PRK02102  84 QLGKKESIEDTARVLGRMYDGIEYRGFKQEIVEELAKYSGVPVWNGLTDEWHPTQMLADFMTMKEHF--GPLKGLKLAYV 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501696293 163 GDAHNNMGNSLLEAASLVGLDLRLVAPKECWPEKNIFKFCKEQIKNKKGNIICTENINEGVKNVDFIYTDVWVSMGESQE 242
Cdd:PRK02102 162 GDGRNNMANSLMVGGAKLGMDVRICAPKELWPEEELVALAREIAKETGAKITITEDPEEAVKGADVIYTDVWVSMGEEDE 241

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501696293 243 vWKKRIELLSSYQVNSLMLKITNNPQVKVLHCLPALHDQKTCTVKSILKKYGfKNGMEITDEVFQKNQKIIFEQAENRLH 322
Cdd:PRK02102 242 -WEERIKLLKPYQVNMDLMKATGNPDVIFMHCLPAFHDTETKVGKEIAEKYG-LKGLEVTDEVFESKYSIVFDEAENRMH 319

                        330
                 ....*....|
gi 501696293 323 TIKAILVSSL 332
Cdd:PRK02102 320 TIKAVMVATL 329
PRK12562 PRK12562
ornithine carbamoyltransferase subunit F; Provisional
 1-334 2.43e-166

ornithine carbamoyltransferase subunit F; Provisional


Pssm-ID: 105755  Cd Length: 334  Bit Score: 466.46  E-value: 2.43e-166
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501696293   1 MNNLYQRDCLRLLDFTSLELQNIITLAQKLKQYKKNNKEIQLLKKKNIALIFEKESTRTRCSFEVAAFDQGAHVTYLGPG 80
Cdd:PRK12562   1 MSGFYKKHFLKLLDFTPAELNSLLQLAAKLKADKKNGKEVARLTGKNIALIFEKDSTRTRCSFEVAAYDQGARVTYLGPS 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501696293  81 STHLGTKESIEDTAKILGRLYDGIQYRGHHHSTIEILAKNSKVPVWNGLTEKFHPTQLLADLLTIKEIFPERKFYEIKCA 160
Cdd:PRK12562  81 GSQIGHKESIKDTARVLGRMYDGIQYRGHGQEVVETLAEYAGVPVWNGLTNEFHPTQLLADLLTMQEHLPGKAFNEMTLV 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501696293 161 YVGDAHNNMGNSLLEAASLVGLDLRLVAPKECWPEKNIFKFCKEQIKNKKGNIICTENINEGVKNVDFIYTDVWVSMGES 240
Cdd:PRK12562 161 YAGDARNNMGNSMLEAAALTGLDLRLVAPQACWPEASLVAECSALAQKHGGKITLTEDIAAGVKGADFIYTDVWVSMGEP 240

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501696293 241 QEVWKKRIELLSSYQVNSLMLKITNNPQVKVLHCLPALHDQKTCTVKSILKKYGFKNGMEITDEVFQKNQKIIFEQAENR 320
Cdd:PRK12562 241 KEKWAERIALLRGYQVNSKMMALTGNPQVKFLHCLPAFHDDQTTLGKKMAKEFGLHGGMEVTDEVFESPASIVFDQAENR 320

                        330
                 ....*....|....
gi 501696293 321 LHTIKAILVSSLLK 334
Cdd:PRK12562 321 MHTIKAVMVATLAK 334
ArgF COG0078
Ornithine carbamoyltransferase [Amino acid transport and metabolism]; Ornithine ...
 2-334 1.23e-160

Ornithine carbamoyltransferase [Amino acid transport and metabolism]; Ornithine carbamoyltransferase is part of the Pathway/BioSystem: Arginine biosynthesis


Pssm-ID: 439848 [Multi-domain]  Cd Length: 310  Bit Score: 451.04  E-value: 1.23e-160
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501696293   2 NNLYQRDCLRLLDFTSLELQNIITLAQKLKQYKKNNKEIQLLKKKNIALIFEKESTRTRCSFEVAAFDQGAHVTYLGPGS 81
Cdd:COG0078    1 TNLKGRHFLSLLDLTPEELRALLDLAAELKAKRKAGIPHRPLKGKTLAMIFEKPSTRTRVSFEVGMAQLGGHAIYLDPGD 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501696293  82 THLGTKESIEDTAKILGRLYDGIQYRGHHHSTIEILAKNSKVPVWNGLTEKFHPTQLLADLLTIKEIFPerKFYEIKCAY 161
Cdd:COG0078   81 SQLGRGESIKDTARVLSRYVDGIMIRTFGHETLEELAKYAGVPVINGLTDLFHPCQALADLLTIREHFG--KLKGLKVAY 158

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501696293 162 VGDAhNNMGNSLLEAASLVGLDLRLVAPKECWPEKNIFKFCKEQIKNKKGNIICTENINEGVKNVDFIYTDVWVSMGESQ 241
Cdd:COG0078  159 VGDG-NNVANSLLLAAAKLGMDVRIATPEGYEPDPEIVAKAKEIAAESGGSITITHDPAEAVKGADVVYTDVWVSMGQEE 237

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501696293 242 EVwKKRIELLSSYQVNSLMLKITnNPQVKVLHCLPALHdqktctvksilkkygfknGMEITDEVFQKNQKIIFEQAENRL 321
Cdd:COG0078  238 EA-EERIKAFKPYQVNEELMALA-KPDAIFMHCLPAHR------------------GEEVTDEVIDGPQSVVFDEAENRL 297

                        330
                 ....*....|...
gi 501696293 322 HTIKAILVSSLLK 334
Cdd:COG0078  298 HAQKALLAWLLGG 310
PRK04284 PRK04284
ornithine carbamoyltransferase; Provisional
 1-332 1.20e-157

ornithine carbamoyltransferase; Provisional


Pssm-ID: 235269 [Multi-domain]  Cd Length: 332  Bit Score: 444.57  E-value: 1.20e-157
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501696293   1 MNNLYQRDCLRLLDFTSLELQNIITLAQKLKQYKKNNKEIQLLKKKNIALIFEKESTRTRCSFEVAAFDQGAHVTYLGPG 80
Cdd:PRK04284   1 MKNLRNRSFLTLLDFTPKEIEYLLDLSEDLKRAKYAGIEVQKLKGKNIALIFEKDSTRTRCAFEVAAYDQGAHVTYLGPT 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501696293  81 STHLGTKESIEDTAKILGRLYDGIQYRGHHHSTIEILAKNSKVPVWNGLTEKFHPTQLLADLLTIKEIFpERKFYEIKCA 160
Cdd:PRK04284  81 GSQMGKKESTKDTARVLGGMYDGIEYRGFSQRTVETLAEYSGVPVWNGLTDEDHPTQVLADFLTAKEHL-KKPYKDIKFT 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501696293 161 YVGDAHNNMGNSLLEAASLVGLDLRLVAPKECWPEKNIFKFCKEQIKNKKGNIICTENINEGVKNVDFIYTDVWVSMGES 240
Cdd:PRK04284 160 YVGDGRNNVANALMQGAAIMGMDFHLVCPKELNPDDELLNKCKEIAAETGGKITITDDIDEGVKGSDVIYTDVWVSMGEP 239

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501696293 241 QEVWKKRIELLSSYQVNSLMLKITNNPQVKVLHCLPALHDQKTCTVKSILKKYGFKnGMEITDEVFQKNQKIIFEQAENR 320
Cdd:PRK04284 240 DEVWEERIKLLKPYQVNKEMMKKTGNPNAIFEHCLPSFHDLDTKVGKEIFEKYGLK-EMEVTDEVFESKASVVFDEAENR 318

                        330
                 ....*....|..
gi 501696293 321 LHTIKAILVSSL 332
Cdd:PRK04284 319 MHTIKAVMVATL 330
orni_carb_tr TIGR00658
ornithine carbamoyltransferase; This family of ornithine carbamoyltransferases (OTCase) is in ...
 7-332 1.16e-144

ornithine carbamoyltransferase; This family of ornithine carbamoyltransferases (OTCase) is in a superfamily with the related enzyme aspartate carbamoyltransferase. Most known examples are anabolic, playing a role in arginine biosynthesis, but some are catabolic. Most OTCases are homotrimers, but the homotrimers are organized into dodecamers built from four trimers in at least two species; the catabolic OTCase of Pseudomonas aeruginosa is allosterically regulated, while OTCase of the extreme thermophile Pyrococcus furiosus shows both allostery and thermophily. [Amino acid biosynthesis, Glutamate family]


Pssm-ID: 129743 [Multi-domain]  Cd Length: 304  Bit Score: 410.59  E-value: 1.16e-144
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501696293    7 RDCLRLLDFTSLELQNIITLAQKLKQYKKNNKEIQLLKKKNIALIFEKESTRTRCSFEVAAFDQGAHVTYLGPGSTHLGT 86
Cdd:TIGR00658   1 RHLLSLLDLSPEEIRYLLQLAKKLKKGKKKGKEHKKLKGKTLALIFEKPSTRTRVSFEVAAYQLGGHPLYLNPNDLQLGR 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501696293   87 KESIEDTAKILGRLYDGIQYRGHHHSTIEILAKNSKVPVWNGLTEKFHPTQLLADLLTIKEIFPerKFYEIKCAYVGDAh 166
Cdd:TIGR00658  81 GESIKDTARVLSRYVDGIMARVYKHEDVEELAKYASVPVINGLTDLFHPCQALADLLTIIEHFG--KLKGVKVVYVGDG- 157

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501696293  167 NNMGNSLLEAASLVGLDLRLVAPKECWPEKNIFKFCKEQIKNKKGNIICTENINEGVKNVDFIYTDVWVSMGESQEvWKK 246
Cdd:TIGR00658 158 NNVCNSLMLAGAKLGMDVVVATPEGYEPDADIVKKAQEIAKENGGSVELTHDPVEAVKGADVIYTDVWVSMGEEDK-KEE 236

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501696293  247 RIELLSSYQVNSLMLKITnNPQVKVLHCLPALHdqktctvksilkkygfknGMEITDEVFQKNQKIIFEQAENRLHTIKA 326
Cdd:TIGR00658 237 RLKLFRPYQVNEELMELA-KPEVIFMHCLPAHR------------------GEEVTDEVIEGPHSIVFDQAENRLHAQKA 297


                  ....*.
gi 501696293  327 ILVSSL 332
Cdd:TIGR00658 298 VMVALL 303
PRK01713 PRK01713
ornithine carbamoyltransferase; Provisional
 3-332 1.53e-139

ornithine carbamoyltransferase; Provisional


Pssm-ID: 167263 [Multi-domain]  Cd Length: 334  Bit Score: 398.59  E-value: 1.53e-139
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501696293   3 NLYQRDCLRLLDFTSLELQNIITLAQKLKQYKKNNKEIQLLKKKNIALIFEKESTRTRCSFEVAAFDQGAHVTYLGPGST 82
Cdd:PRK01713   4 NLKNRHLLSLVNHTEREIKYLLDLSRDLKRAKYAGTEQQRLKGKNIALIFEKTSTRTRCAFEVAAYDQGAQVTYIDPNSS 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501696293  83 HLGTKESIEDTAKILGRLYDGIQYRGHHHSTIEILAKNSKVPVWNGLTEKFHPTQLLADLLTIKEiFPERKFYEIKCAYV 162
Cdd:PRK01713  84 QIGHKESMKDTARVLGRMYDAIEYRGFKQSIVNELAEYAGVPVFNGLTDEFHPTQMLADVLTMIE-NCDKPLSEISYVYI 162

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501696293 163 GDAHNNMGNSLLEAASLVGLDLRLVAPKECWPEKNIFKFCKEQIKNKKGNIICTENINEGVKNVDFIYTDVWVSMGESQE 242
Cdd:PRK01713 163 GDARNNMGNSLLLIGAKLGMDVRICAPKALLPEASLVEMCEKFAKESGARITVTDDIDKAVKGVDFVHTDVWVSMGEPLE 242

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501696293 243 VWKKRIELLSSYQVNSLMLKITNNPQVKVLHCLPALHDQKTCTVKSILKKY-GFKNGMEITDEVFQKNQKIIFEQAENRL 321
Cdd:PRK01713 243 TWGERIKLLMPYQVTPELMKRTGNPKVKFMHCLPAFHNSETKVGRQIAEKYpELANGIEVTEDVFESPMNIAFEQAENRM 322

                        330
                 ....*....|.
gi 501696293 322 HTIKAILVSSL 332
Cdd:PRK01713 323 HTIKAVMVASL 333
PRK00779 PRK00779
ornithine carbamoyltransferase; Provisional
 7-329 1.04e-119

ornithine carbamoyltransferase; Provisional


Pssm-ID: 234835 [Multi-domain]  Cd Length: 304  Bit Score: 347.08  E-value: 1.04e-119
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501696293   7 RDCLRLLDFTSLELQNIITLAQKLKQYKKNNKEIQLLKKKNIALIFEKESTRTRCSFEVAAFDQGAHVTYLGPGSTHLGT 86
Cdd:PRK00779   5 RHFLSLDDLSPEELEELLDLAAELKKKRKAGEPHPPLKGKTLAMIFEKPSTRTRVSFEVGMAQLGGHAIFLSPRDTQLGR 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501696293  87 KESIEDTAKILGRLYDGIQYRGHHHSTIEILAKNSKVPVWNGLTEKFHPTQLLADLLTIKEIFPERKfyEIKCAYVGDAh 166
Cdd:PRK00779  85 GEPIEDTARVLSRYVDAIMIRTFEHETLEELAEYSTVPVINGLTDLSHPCQILADLLTIYEHRGSLK--GLKVAWVGDG- 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501696293 167 NNMGNSLLEAASLVGLDLRLVAPKECWPEKNIFKFckeQIKNKKGNIICTENINEGVKNVDFIYTDVWVSMGESQEVwKK 246
Cdd:PRK00779 162 NNVANSLLLAAALLGFDLRVATPKGYEPDPEIVEK---IAKETGASIEVTHDPKEAVKGADVVYTDVWVSMGQEAEA-EE 237

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501696293 247 RIELLSSYQVNSLMLKITnNPQVKVLHCLPAlHdqktctvksilkkygfkNGMEITDEVFQKNQKIIFEQAENRLHTIKA 326
Cdd:PRK00779 238 RLKAFAPYQVNEELMALA-KPDAIFMHCLPA-H-----------------RGEEVTDEVIDGPQSVVWDEAENRLHAQKA 298


                 ...
gi 501696293 327 ILV 329
Cdd:PRK00779 299 LLA 301
PLN02342 PLN02342
ornithine carbamoyltransferase
 7-332 3.59e-77

ornithine carbamoyltransferase


Pssm-ID: 177976 [Multi-domain]  Cd Length: 348  Bit Score: 240.46  E-value: 3.59e-77
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501696293   7 RDCLRLLDFTSLELQNIITLAQKLK-QYKKNNKEIQLLKKKNIALIFEKESTRTRCSFEVAAFDQGAHVTYLGPGSTHLG 85
Cdd:PLN02342  46 KHFLHIDDFDKEEILGLLDRAKEVKaLLKSGDRSFQPFKGKSMAMIFTKPSMRTRVSFETGFFLLGGHALYLGPDDIQLG 125

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501696293  86 TKESIEDTAKILGRLYDGIQYRGHHHSTIEILAKNSKVPVWNGLTEKFHPTQLLADLLTIKEIFPERKfyEIKCAYVGDA 165
Cdd:PLN02342 126 KREETRDIARVLSRYNDIIMARVFAHQDVLDLAEYSSVPVINGLTDYNHPCQIMADALTIIEHIGRLE--GTKVVYVGDG 203

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501696293 166 hNNMGNSLLEAASLVGLDLRLVAPKECWPEKNIFKFCKEQIKNKkgnIICTENINEGVKNVDFIYTDVWVSMGESQEVwK 245
Cdd:PLN02342 204 -NNIVHSWLLLAAVLPFHFVCACPKGYEPDAKTVEKARAAGISK---IEITNDPAEAVKGADVVYTDVWASMGQKEEA-E 278

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501696293 246 KRIELLSSYQVNSLMLKITnNPQVKVLHCLPAlhdqktctvksilkkygfKNGMEITDEVFQKNQKIIFEQAENRLHTIK 325
Cdd:PLN02342 279 KRKKAFQGFQVNEALMKLA-GPQAYFMHCLPA------------------ERGVEVTDGVMEAPNSIVFPQAENRMHAQN 339


                 ....*..
gi 501696293 326 AILVSSL 332
Cdd:PLN02342 340 AIMLHQL 346
PRK14805 PRK14805
ornithine carbamoyltransferase; Provisional
 7-332 4.94e-72

ornithine carbamoyltransferase; Provisional


Pssm-ID: 237819 [Multi-domain]  Cd Length: 302  Bit Score: 225.72  E-value: 4.94e-72
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501696293   7 RDCLRLLDFTSLELQNIITLAQKLKQYKKNNKeiQLLKKKNIALIFEKESTRTRCSFEVAAFDQGAHVTYLGPGSTHLGT 86
Cdd:PRK14805   2 KHLLSIKELTQQQLLDLLALAKTIKANPAEYR--QALAGKSVVMLFEKPSLRTRVSFDIGINKLGGHCLYLDQQNGALGK 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501696293  87 KESIEDTAKILGRLYDGIQYRGHHHSTIEILAKNSKVPVWNGLTEKFHPTQLLADLLTIKEIFPERKfyEIKCAYVGDAh 166
Cdd:PRK14805  80 RESVADFAANLSCWADAIVARVFSHSTIEQLAEHGSVPVINALCDLYHPCQALADFLTLAEQFGDVS--KVKLAYVGDG- 156

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501696293 167 NNMGNSLLEAASLVGLDLRLVAPKECWPEKNIFKFCKEQIKNKKGNIICTENINEgVKNVDFIYTDVWVSMGES---QEV 243
Cdd:PRK14805 157 NNVTHSLMYGAAILGATMTVICPPGHFPDGQIVAEAQELAAKSGGKLVLTSDIEA-IEGHDAIYTDTWISMGDDtplAEI 235

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501696293 244 WKKrielLSSYQVNSLMLKITNNPQvkVLHCLPAlHdqktctvksilkkygfkNGMEITDEVFQKNQKIIFEQAENRLHT 323
Cdd:PRK14805 236 KAK----FAPYQVNKALMEKAGATF--VMHCQPA-H-----------------RGVEITSEVMDGEGSLILQQAENRMHA 291


                 ....*....
gi 501696293 324 IKAILVSSL 332
Cdd:PRK14805 292 QNAVLVTLL 300
OTCace_N pfam02729
Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain;
8-147 4.79e-65

Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain;


Pssm-ID: 460665 [Multi-domain]  Cd Length: 140  Bit Score: 201.89  E-value: 4.79e-65
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501696293    8 DCLRLLDFTSLELQNIITLAQKLKQYKKNNKEIQLLKKKNIALIFEKESTRTRCSFEVAAFDQGAHVTYLGPGSTHLGTK 87
Cdd:pfam02729   1 HFLSLEDLSREEIEALLDLAAELKEARKRGKKLPLLKGKTVALLFEEPSTRTRVSFEVAAKRLGGHVIYLSSSDIQLSSG 80

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 501696293   88 ESIEDTAKILGRLYDGIQYRGHHHSTIEILAKNSKVPVWNGLTEKFHPTQLLADLLTIKE 147
Cdd:pfam02729  81 ESLADTARVLSRYVDAIVIRHFGHEDLEELAEYASVPVINAGGDHEHPTQALADLLTIRE 140
OTCace pfam00185
Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain;
158-330 3.82e-60

Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain;


Pssm-ID: 425511 [Multi-domain]  Cd Length: 154  Bit Score: 189.74  E-value: 3.82e-60
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501696293  158 KCAYVGDAHNNMGNSLLEAASLVGLDLRLVAPKECWPEKNIFKFCKEQIKNKKGNIICTENINEGVKNVDFIYTDVWVSM 237
Cdd:pfam00185   1 KIAYVGDGHNNVAHSLIIAAAKLGMDVRLATPKGYPPDPEVLDKAKKIAEKSGGSIEITDDPAEAVKGADVVYTDVWQSM 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501696293  238 GESQEvWKKRIELLSSYQVNSLMLKITnNPQVKVLHCLPALHdqktctvksilkkygfknGMEITDEVFQKNQKIIFEQA 317
Cdd:pfam00185  81 GQEKE-REERLKAFKPYQVNEELMKLA-KKDAIFMHCLPAHR------------------GEEVTDDVFDGPRSVVFDQA 140

                         170
                  ....*....|...
gi 501696293  318 ENRLHTIKAILVS 330
Cdd:pfam00185 141 ENRLHAQKALLAL 153
PRK14804 PRK14804
ornithine carbamoyltransferase; Provisional
 14-332 1.67e-52

ornithine carbamoyltransferase; Provisional


Pssm-ID: 173265 [Multi-domain]  Cd Length: 311  Bit Score: 175.60  E-value: 1.67e-52
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501696293  14 DFTSLELQNIITLAQKLKQYKKNNKeiQLLKKKNIALIFEKESTRTRCSFEVAAFDQGAHVTYLGPGSTHLGTKEsIEDT 93
Cdd:PRK14804  14 DWSDSEILDLLDFAVHVKKNRVNYA--GHMSGRSLAMLFQKTSTRTRVSFEVAMTEMGGHGIYLDWMASNFQLSD-IDLE 90

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501696293  94 AKILGRLYDGIQYRGHHHSTIEILAKNSKVPVWNGLTEKFHPTQLLADLLTIKEIFPERKFYEIKCAYVGdAHNNMGNSL 173
Cdd:PRK14804  91 ARYLSRNVSVIMARLKKHEDLLVMKNGSQVPVINGCDNMFHPCQSLADIMTIALDSPEIPLNQKQLTYIG-VHNNVVNSL 169

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501696293 174 LEAASLVGLDLRLVAPkeCWPEKNIFKFCKEQIKnKKGNIICTENINEGVKNVDFIYTDVWVSMG-----ESQEVWKKRI 248
Cdd:PRK14804 170 IGITAALGIHLTLVTP--IAAKENIHAQTVERAK-KKGTLSWEMNLHKAVSHADYVYTDTWLDMEffndpSYADKKKQRM 246

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501696293 249 ELLSSYQVNSLMLKITNnpqVKVLHCLPaLHdqktctvksilkkygfkNGMEITDEVFQKNQKIIFEQAENRLHTIKAIL 328
Cdd:PRK14804 247 ELMMPYQINSSLMEKTN---AKVMHDMP-IH-----------------AGYEITREVVLSDRSIIFQQAENRLDAQKAVI 305


                 ....
gi 501696293 329 VSSL 332
Cdd:PRK14804 306 LKLL 309
PyrB COG0540
Aspartate carbamoyltransferase, catalytic subunit [Nucleotide transport and metabolism]; ...
 2-319 4.56e-36

Aspartate carbamoyltransferase, catalytic subunit [Nucleotide transport and metabolism]; Aspartate carbamoyltransferase, catalytic subunit is part of the Pathway/BioSystem: Pyrimidine biosynthesis


Pssm-ID: 440306 [Multi-domain]  Cd Length: 306  Bit Score: 132.10  E-value: 4.56e-36
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501696293   2 NNLYQRDCLRLLDFTSLELQNIITLAQKLKQYKKNNKEIQLLKKKNIALIFEKESTRTRCSFEVAAFDQGAHVTYLGPGS 81
Cdd:COG0540    1 MSFKMRHLLSIEDLSREEIEELLDTAEEFKEVLRPIKKVPLLRGKTVANLFFEPSTRTRLSFELAAKRLGADVINFSAST 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501696293  82 THLGTKESIEDTAKILGRL-YDGIQYRgHHHS-TIEILAKNSKVPVWN---GLTEkfHPTQLLADLLTIKEIFPerKFYE 156
Cdd:COG0540   81 SSVSKGESLADTIRTLEAYgADAIVIR-HPQEgAARLLAEHVDVPVINagdGAHE--HPTQALLDLYTIREEFG--RLDG 155

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501696293 157 IKCAYVGD------AHnnmgnSLLEAASLVGLDLRLVAPKEcWPEKNIfkfckeqiknKKGNIICTENINEGVKNVDFIY 230
Cdd:COG0540  156 LKVAIVGDlkhsrvAR-----SNIKALSKLGAEVTLVAPPT-LLPEEI----------EELGVEVTTDLDEALPDADVVY 219

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501696293 231 tdvwvsM-------GESQEVWKKRiELLSSYQVNSLMLKITnNPQVKVLHCLPalhdqktctvksilkkygFKNGMEITD 303
Cdd:COG0540  220 ------MlriqkerFTDGLFPSYR-EYKRSYGLTAERLALA-KPDAIVMHPGP------------------RNRGVEIDS 273

                        330
                 ....*....|....*.
gi 501696293 304 EVFQKNQKIIFEQAEN 319
Cdd:COG0540  274 DVDDTPRSVIFEQVTN 289
asp_carb_tr TIGR00670
aspartate carbamoyltransferase; Aspartate transcarbamylase (ATCase) is an alternate name.PyrB ...
 7-319 7.10e-35

aspartate carbamoyltransferase; Aspartate transcarbamylase (ATCase) is an alternate name.PyrB encodes the catalytic chain of aspartate carbamoyltransferase, an enzyme of pyrimidine biosynthesis, which organizes into trimers. In some species, including E. coli and the Archaea but excluding Bacillus subtilis, a regulatory subunit PyrI is also present in an allosterically regulated hexameric holoenzyme. Several molecular weight classes of ATCase are described in MEDLINE:96303527 and often vary within taxa. PyrB and PyrI are fused in Thermotoga maritima.Ornithine carbamoyltransferases are in the same superfamily and form an outgroup. [Purines, pyrimidines, nucleosides, and nucleotides, Pyrimidine ribonucleotide biosynthesis]


Pssm-ID: 273209 [Multi-domain]  Cd Length: 301  Bit Score: 129.02  E-value: 7.10e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501696293    7 RDCLRLLDFTSLELQNIITLAQKLKQYKKNNKEIQLLKKKNIALIFEKESTRTRCSFEVAAFDQGAHV-TYLGPGSTHLG 85
Cdd:TIGR00670   1 RHLISISDLSREEIELLLETARELEQVLNGKEPLKLLKGKILANLFFEPSTRTRLSFETAMKRLGGSVvNFSDSETSSVA 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501696293   86 TKESIEDTAKILGRLYDGIQYRGHHHSTIEILAKNSKVPVWN-GLTEKFHPTQLLADLLTIKEIFPERKFyeIKCAYVGD 164
Cdd:TIGR00670  81 KGETLADTIKTLSGYVDAIVIRHPLEGAARLAAEVSEVPVINaGDGSNQHPTQTLLDLYTIYEEFGRLDG--LKIALVGD 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501696293  165 -AHNNMGNSLLEAASLVGLDLRLVAPKECWPEKNIFkfckEQIKNKKGNIICTENINEGVKNVDFIYTdvwvsmgesQEV 243
Cdd:TIGR00670 159 lKYGRTVHSLAEALTRFGVEVYLISPEELRMPKEIL----EELKAKGIKVRETESLEEVIDEADVLYV---------TRI 225

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501696293  244 WKKRIELLSSYQVNSLMLKITNN------PQVKVLHCLPalhdqktctvksilkkygfkNGMEITDEVFQKNQKIIFEQA 317
Cdd:TIGR00670 226 QKERFPDPEEYEKVKGSYGITLErleaakKGVIIMHPLP--------------------RVDEIDPSVDDTPHAKYFKQA 285


                  ..
gi 501696293  318 EN 319
Cdd:TIGR00670 286 FN 287
pyrB PRK00856
aspartate carbamoyltransferase catalytic subunit;
2-328 2.15e-33

aspartate carbamoyltransferase catalytic subunit;


Pssm-ID: 234849 [Multi-domain]  Cd Length: 305  Bit Score: 125.19  E-value: 2.15e-33
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501696293   2 NNLYQRDCLRLLDFTSLELQNIITLAQKLKQY-KKNNKEIQLLKKKNIALIFEKESTRTRCSFEVAAFDQGAHVTYLGPG 80
Cdd:PRK00856   1 NPLKMKHLLSIEDLSREEIELLLDTAEEFKEVlRREVKKVPLLRGKTVANLFFEPSTRTRLSFELAAKRLGADVINFSAS 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501696293  81 STHLgTK-ESIEDTAKILGRLY-DGIQYRgHHHS-TIEILAKNSKVPVWN---GLTEkfHPTQLLADLLTIKEIFPerKF 154
Cdd:PRK00856  81 TSSV-SKgETLADTIRTLSAMGaDAIVIR-HPQSgAARLLAESSDVPVINagdGSHQ--HPTQALLDLLTIREEFG--RL 154

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501696293 155 YEIKCAYVGD------AHnnmgnSLLEAASLVGLDLRLVAPKECWPEKniFKFCKEqiknkkgniicTENINEGVKNVDF 228
Cdd:PRK00856 155 EGLKVAIVGDikhsrvAR-----SNIQALTRLGAEVRLIAPPTLLPEG--MPEYGV-----------HTDLDEVIEDADV 216

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501696293 229 IY---------TDvwvSMGESQEvwkkriELLSSYQVNSLMLKITnNPQVKVLHCLPALHdqktctvksilkkygfknGM 299
Cdd:PRK00856 217 VMmlrvqkermDG---GLLPSYE------EYKRSYGLTAERLALA-KPDAIVMHPGPVNR------------------GV 268

                        330       340
                 ....*....|....*....|....*....
gi 501696293 300 EITDEVFQKNQKIIFEQAENRLHTIKAIL 328
Cdd:PRK00856 269 EIASDVADGPQSVIFEQVTNGVAVRMAVL 297
PRK04523 PRK04523
N-acetylornithine carbamoyltransferase; Reviewed
 10-328 3.07e-31

N-acetylornithine carbamoyltransferase; Reviewed


Pssm-ID: 235304 [Multi-domain]  Cd Length: 335  Bit Score: 120.24  E-value: 3.07e-31
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501696293  10 LRLLDFTSLELQNIITLAQKLKQykknNKEIQLLKKKNIALIFEKESTRTRCSFEVAAFDQGAHVTYLGPGST------H 83
Cdd:PRK04523   7 LNTQDWSRAELDALLTQAAAFKR----NKLGSALKGKSIALVFFNPSLRTRTSFELGAFQLGGHAVVLQPGKDawpiefE 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501696293  84 LGT------KESIEDTAKILGRLYDGIQYRGHHHST----------IEILAKNSKVPVWNgLTEKFHPTQLLADLLTIKE 147
Cdd:PRK04523  83 LGAvmdgetEEHIREVARVLSRYVDLIGVRAFPKFVdwskdrqdqvLNSFAKYSTVPVIN-METITHPCQELAHALALQE 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501696293 148 IF---PERKFYEIKCAYvgdaHN---NMG--NSLLEAASLVGLDLRLVAPKE---------CWPEKNifkfckeqIKNKK 210
Cdd:PRK04523 162 HFgttLRGKKYVLTWTY----HPkplNTAvaNSALLIATRLGMDVTLLCPTPdyilderymDWAEQN--------AAESG 229

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501696293 211 GNIICTENINEGVKNVDFIYTDVWVSMgESQEVWKKRIELLSSYQ---VNSLMLKITNNpqVKVLHCLPalhdqktctvk 287
Cdd:PRK04523 230 GSLTVSHDIDSAYAGADVVYAKSWGAL-PFFGNWEPEKPIRDQYQhfiVDERKMALTNN--GVFSHCLP----------- 295

                        330       340       350       360
                 ....*....|....*....|....*....|....*....|.
gi 501696293 288 silkkygFKNGMEITDEVFQKNQKIIFEQAENRLHTIKAIL 328
Cdd:PRK04523 296 -------LRRNVKVTDAVMDSPNCIAIDEAENRLHVQKAIM 329
PLN02527 PLN02527
aspartate carbamoyltransferase
 8-335 9.46e-15

aspartate carbamoyltransferase


Pssm-ID: 178142 [Multi-domain]  Cd Length: 306  Bit Score: 73.63  E-value: 9.46e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501696293   8 DCLRLLDFTSLELQNIITLAQKLKQYKKNNKEIQLLKKKNIALIFEKESTRTRCSFEVAAFDQGAHV-TYLGPGSTHLGT 86
Cdd:PLN02527   2 DVIEAQQFDREMLELLFEVAREMEKVERGSPGSQMLKGYLMATLFYEPSTRTRLSFESAMKRLGGEVlTTENAGEFSSAA 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501696293  87 K-ESIEDTAKILGRLYDGIQYRGHHHSTIEILAKNSKVPVWN---GLTEkfHPTQLLADLLTI-KEIfpeRKFYEIKCAY 161
Cdd:PLN02527  82 KgETLEDTIRTVEGYSDIIVLRHFESGAARRAAATAEIPVINagdGPGQ--HPTQALLDVYTIqREI---GRLDGIKVGL 156

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501696293 162 VGDAHNnmGNSLLEAASLV----GLDLRLVAPKECWPEKNIFKFCKEQiknkkgNIICTE--NINEGVKNVDFIY-TDVw 234
Cdd:PLN02527 157 VGDLAN--GRTVRSLAYLLakyeDVKIYFVAPDVVKMKDDIKDYLTSK------GVEWEEssDLMEVASKCDVLYqTRI- 227

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501696293 235 vsmgeSQEVWKKRIELLS----SYQVNSLMLKITNNPQVkVLHCLPALHdqktctvksilkkygfkngmEITDEVFQKNQ 310
Cdd:PLN02527 228 -----QRERFGERIDLYEaargKYIVDKKVMDVLPKHAV-VMHPLPRLD--------------------EITTDVDSDPR 281

                        330       340
                 ....*....|....*....|....*
gi 501696293 311 KIIFEQAENRLHTIKAILVSSLLKT 335
Cdd:PLN02527 282 AAYFRQAKNGLFIRMALLKLLLGGW 306
PRK08192 PRK08192
aspartate carbamoyltransferase; Provisional
 20-230 1.06e-14

aspartate carbamoyltransferase; Provisional


Pssm-ID: 169269 [Multi-domain]  Cd Length: 338  Bit Score: 73.99  E-value: 1.06e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501696293  20 LQNIITLAQKLKQYKKNNKEIQLLKKKNIALIFEKESTRTRCSFEVAAFDQGAHVT-YLGPGSTHLGTKESIEDTAKILG 98
Cdd:PRK08192  19 IQRIFNVADRMEPYALREKRTRVLEGAILGNLFFEPSTRTRVSFGCAFNLLGGHVReTTGMASSSLSKGESLYDTARVLS 98

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501696293  99 RLYDGIQYRGHHHSTIEILAKNSKVPVWN---GLTEkfHPTQLLADLLTI-KEI-FPERKFYEIKCAYVGDAHNnmGNSL 173
Cdd:PRK08192  99 TYSDVIAMRHPDAGSVKEFAEGSRVPVINggdGSNE--HPTQALLDLFTIqKELaHAGRGIDGMHIAMVGDLKF--GRTV 174

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 501696293 174 LEAASLVGL----DLRLVAPKE-CWPEKNIfkfckEQIKNKKGNIICTENINEGVKNVDFIY 230
Cdd:PRK08192 175 HSLSRLLCMyknvSFTLVSPKElAMPDYVI-----SDIENAGHKITITDQLEGNLDKADILY 231
PRK11891 PRK11891
aspartate carbamoyltransferase; Provisional
 50-276 7.28e-14

aspartate carbamoyltransferase; Provisional


Pssm-ID: 183362 [Multi-domain]  Cd Length: 429  Bit Score: 71.82  E-value: 7.28e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501696293  50 LIFEKeSTRTRCSFEvAAFDQ--GAHVTYLGPGSTHLGTKESIEDTAKILGRLYDGIQYRGHHHSTIEILAKNSKVPVWN 127
Cdd:PRK11891 132 LFFEA-STRTRVSFG-AAFCRlgGSVCDTTGFTFSSMAKGESIYDTSRVMSGYVDALVIRHPEQGSVAEFARATNLPVIN 209

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501696293 128 ---GLTEkfHPTQLLADLLTIKEIFPER-KFYEIKC-AYVGD-AHNNMGNSLLEAASLV-GLDLRLVAPkecwPEKNIFK 200
Cdd:PRK11891 210 ggdGPGE--HPSQALLDLYTIQREFSRLgKIVDGAHiALVGDlKYGRTVHSLVKLLALYrGLKFTLVSP----PTLEMPA 283

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501696293 201 FCKEQIkNKKGNII-CTENINEGVKNVDFIYtdvwvsmgeSQEVWKKRI--ELLSSY----QVNSLMLKITNNPQVKVLH 273
Cdd:PRK11891 284 YIVEQI-SRNGHVIeQTDDLAAGLRGADVVY---------ATRIQKERFadESFEGYtpdfQINQALVDAVCKPDTLIMH 353


                 ...
gi 501696293 274 CLP 276
Cdd:PRK11891 354 PLP 356
pyrB PRK13814
aspartate carbamoyltransferase;
10-196 2.02e-13

aspartate carbamoyltransferase;


Pssm-ID: 139876 [Multi-domain]  Cd Length: 310  Bit Score: 69.75  E-value: 2.02e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501696293  10 LRLLDFTSLELQNIITLAQK----LKQYKKNNKEIQLLKKKNIALIFEKESTRTRCSFEVAAFDQGAHVTYLGPGSTHLG 85
Cdd:PRK13814   6 LHLLNMRSLTRDHIEKLIQRanyfLTQGMEKNSVFETLKGHVVANLFFEPSTRTRNSFEIAAKRLGAMVLNPNLKISAIS 85

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501696293  86 TKESIEDTAKILGRLydGIQY---RGHHHSTIEILAK--NSKVPVWNGLTEKFHPTQLLADLLTIKEIFPErkFYEIKCA 160
Cdd:PRK13814  86 KGETLFDTIKTLEAM--GVYFfivRHSENETPEQIAKqlSSGVVINAGDGNHQHPSQALIDLMTIKQHKPH--WNKLCVT 161

                        170       180       190
                 ....*....|....*....|....*....|....*...
gi 501696293 161 YVGDA-HNNMGNSLLEAASLVGL-DLRLVAPKECWPEK 196
Cdd:PRK13814 162 IIGDIrHSRVANSLMDGLVTMGVpEIRLVGPSSLLPDK 199
PRK07200 PRK07200
aspartate/ornithine carbamoyltransferase family protein; Validated
 3-334 6.74e-11

aspartate/ornithine carbamoyltransferase family protein; Validated


Pssm-ID: 235961 [Multi-domain]  Cd Length: 395  Bit Score: 62.83  E-value: 6.74e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501696293   3 NLYQRDCLRLLDFTSLELQNIITLAQKLKQYKKNNKEIQLLKKKNIALIFEKESTRTRCSFEVAAFDQGAHVTYLGPGST 82
Cdd:PRK07200  17 HMHEKDFLLTWEKTPDELKAVLDVADALRALREENISTKVFNSGLGISVFRDNSTRTRFSYASACNLLGLEVQDLDEGKS 96

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501696293  83 HLGTKESIEDTAKILGRLYDGI-----QYRGHHHSTIEILAKNSKVPVWNGLTEKF-----------HPTQLLADLLTIK 146
Cdd:PRK07200  97 QIAHGETVRETANMISFMADVIgirddMYIGKGNAYMREVGAAVDDGYKQGVLPQRptlvnlqcdidHPTQSMADLLHLI 176

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501696293 147 EIFPERKFYEIKCAYVGDAHN-NMGNSLLEAASLVGL------DLRLVAPK--ECWPEknIFKFCKEQIKNKKGNIICTE 217
Cdd:PRK07200 177 EHFGGLENLKGKKIAMTWAYSpSYGKPLSVPQGIIGLmtrfgmDVTLAHPEgyDLMPE--VVEVAKKNAKASGGSFRQVN 254

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501696293 218 NINEGVKNVDFIYTDVW---VSMGESQEVWKK---------RIELLSS------YQVNSLMLKITNNPQVKVLHCLPALH 279
Cdd:PRK07200 255 SMEEAFKDADIVYPKSWapyKVMEERTELYRAgdhegikalEKELLAQnaqhkdWHCTEEMMKLTKDGKALYMHCLPADI 334

                        330       340       350       360       370
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 501696293 280 DQKTCtvksilkkygfKNGmEITDEVFQKNQKIIFEQAENRLHTIKAILVSSLLK 334
Cdd:PRK07200 335 SGVSC-----------KEG-EVTESVFDRYRIALYKEASWKPYIIAAMIFLRKYK 377
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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