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Conserved domains on  [gi|501835832|ref|WP_012651864|]
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MULTISPECIES: N-acetylglucosamine kinase [Rhizobium/Agrobacterium group]

Protein Classification

N-acetylglucosamine kinase( domain architecture ID 10006823)

N-acetylglucosamine kinase of eukaryotic type similar to Clostridium acetobutylicum N-acetylmuramic acid/N-acetylglucosamine kinase.

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
ASKHA_NBD_GspK-like cd24082
nucleotide-binding domain (NBD) of Vibrio cholerae glucosamine kinase GspK and similar ...
 6-281 1.38e-102

nucleotide-binding domain (NBD) of Vibrio cholerae glucosamine kinase GspK and similar proteins; The family includes a group of uncharacterized proteins similar to Vibrio cholerae glucosamine kinase GspK (EC 2.7.1.8), also called GlcN kinase. It acts as ATP-dependent kinase, which is specific for glucosamine. GspK does not show kinase activity with any other sugar.


:

Pssm-ID: 466932 [Multi-domain]  Cd Length: 279  Bit Score: 300.99  E-value: 1.38e-102
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501835832   6 IGIDGGGTSCRAAVTDRTGKILGAGKAGASNILSDLENSRNNVVASARQALVDAGLDPGLTDKLPAVIGTAGANVGDYGK 85
Cdd:cd24082    3 IGIDGGGTKCRARLADADGTVLGEATGGPANLSSDLDQAWASILAAIKQALAQAGLDAAALSDLHAGLGLAGANVPEARA 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501835832  86 RLEKALP-FATVHVVTDAAIALQGALGDADGIIGAFGTGSVYNARRDGKSWGIGGWGFVVGDQASGARLGRDLLERSILA 164
Cdd:cd24082   83 AFLAALPpFASLVVVSDAHIACLGAHGGEDGAIIILGTGSVGAALDGGEVRQVGGWGFPLGDEGSGAWLGLRALRHTLLA 162

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501835832 165 HDSVSRPSPLTETLMTEFEGDPERVVEFAHAAKPKDFARYAPMVFEYAEKSDAVAVDIVKTAVNAIAQSLDALLWPDCPS 244
Cdd:cd24082  163 LDGLAPSSPLTRAVLARFGGDPAEIVAWANTATPADFAALAPLVFEAAEQGDPVALAILQEAAAYIERLLRALGAQGALP 242

                        250       260       270
                 ....*....|....*....|....*....|....*..
gi 501835832 245 ICLLGGLSKAYYPWLDTRYKALLREPKGDALSGAIEL 281
Cdd:cd24082  243 LCLLGGLAERLAPYLPEDLQARLVPPKGDALDGALLL 279
 
Name Accession Description Interval E-value
ASKHA_NBD_GspK-like cd24082
nucleotide-binding domain (NBD) of Vibrio cholerae glucosamine kinase GspK and similar ...
 6-281 1.38e-102

nucleotide-binding domain (NBD) of Vibrio cholerae glucosamine kinase GspK and similar proteins; The family includes a group of uncharacterized proteins similar to Vibrio cholerae glucosamine kinase GspK (EC 2.7.1.8), also called GlcN kinase. It acts as ATP-dependent kinase, which is specific for glucosamine. GspK does not show kinase activity with any other sugar.


Pssm-ID: 466932 [Multi-domain]  Cd Length: 279  Bit Score: 300.99  E-value: 1.38e-102
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501835832   6 IGIDGGGTSCRAAVTDRTGKILGAGKAGASNILSDLENSRNNVVASARQALVDAGLDPGLTDKLPAVIGTAGANVGDYGK 85
Cdd:cd24082    3 IGIDGGGTKCRARLADADGTVLGEATGGPANLSSDLDQAWASILAAIKQALAQAGLDAAALSDLHAGLGLAGANVPEARA 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501835832  86 RLEKALP-FATVHVVTDAAIALQGALGDADGIIGAFGTGSVYNARRDGKSWGIGGWGFVVGDQASGARLGRDLLERSILA 164
Cdd:cd24082   83 AFLAALPpFASLVVVSDAHIACLGAHGGEDGAIIILGTGSVGAALDGGEVRQVGGWGFPLGDEGSGAWLGLRALRHTLLA 162

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501835832 165 HDSVSRPSPLTETLMTEFEGDPERVVEFAHAAKPKDFARYAPMVFEYAEKSDAVAVDIVKTAVNAIAQSLDALLWPDCPS 244
Cdd:cd24082  163 LDGLAPSSPLTRAVLARFGGDPAEIVAWANTATPADFAALAPLVFEAAEQGDPVALAILQEAAAYIERLLRALGAQGALP 242

                        250       260       270
                 ....*....|....*....|....*....|....*..
gi 501835832 245 ICLLGGLSKAYYPWLDTRYKALLREPKGDALSGAIEL 281
Cdd:cd24082  243 LCLLGGLAERLAPYLPEDLQARLVPPKGDALDGALLL 279
BadF COG2971
BadF-type ATPase, related to human N-acetylglucosamine kinase [Carbohydrate transport and ...
 6-286 5.86e-72

BadF-type ATPase, related to human N-acetylglucosamine kinase [Carbohydrate transport and metabolism];


Pssm-ID: 442210 [Multi-domain]  Cd Length: 298  Bit Score: 223.60  E-value: 5.86e-72
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501835832   6 IGIDGGGTSCRAAVTDRTGKILGAGKAGASNILS-DLENSRNNVVASARQALVDAGLDPGLTdklPAVIGTAGANVGDYG 84
Cdd:COG2971    4 LGVDGGGTKTRAVLVDADGEVLGRGRAGGANPQSvGLEEALASLREALEEALAAAGDPADIE---AVGFGLAGAGTPEDA 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501835832  85 KRLEKAL----PFATVHVVTDAAIALQGALGDADGIIGAFGTGSVYNARR-DGKSWGIGGWGFVVGDQASGARLGRDLLE 159
Cdd:COG2971   81 EALEAALrelfPFARVVVVNDALAALAGALGGEDGIVVIAGTGSIAAGRDgDGRTARVGGWGYLLGDEGSGAWLGREALR 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501835832 160 RSILAHDSVSRPSPLTETLMTEFEGD-PERVVEFAHA--AKPKDFARYAPMVFEYAEKSDAVAVDIVKTAVNAIAQSLDA 236
Cdd:COG2971  161 AALRALDGRGPPTALTEAVLAEFGLDdPEELIAWVYRgpAPPADLASLAPLVFEAAEAGDPVARAILEEAADELAELARA 240

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 501835832 237 LLWPDCPSICLLGGLSKAyYPWLDTRYKALL-------REPKGDALSGAIELAAKLL 286
Cdd:COG2971  241 LLERGALPVVLAGGVAAA-QPLLREALRARLaaggaeiVPPAGDPVDGALLLALRLL 296
BcrAD_BadFG pfam01869
BadF/BadG/BcrA/BcrD ATPase family; This family includes the BadF and BadG proteins that are ...
 6-255 4.88e-22

BadF/BadG/BcrA/BcrD ATPase family; This family includes the BadF and BadG proteins that are two subunits of Benzoyl-CoA reductase, that may be involved in ATP hydrolysis. The family also includes an activase subunit from the enzyme 2-hydroxyglutaryl-CoA dehydratase. The protein Swiss:O66634 contains two copies of this region suggesting that the family may structurally dimerize. This family appears to be related to pfam00370.


Pssm-ID: 396441 [Multi-domain]  Cd Length: 271  Bit Score: 92.80  E-value: 4.88e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501835832    6 IGIDGGGTSCRAAVTDRTGKILGAGKAGASNILS-DLENSRNNVVASARQALVDAGLDPGLTDklpaVIGTAGANVGDYG 84
Cdd:pfam01869   1 LGIDGGSTKTKAVLMDDDGEVLGRAIAGSANFESvGVEAAERNLKDAITEALEEAGLKLDDIE----YMFLGLTGYGRAG 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501835832   85 --KRLEKALPFATVHVVTDAAIALQGALGDADGIIGAFGTGSVYNARRDGKSWGIGGWGFVVGDQASGARLGRDLLERSI 162
Cdd:pfam01869  77 vdGHFGKDIVREEITVHADGAVALAPGTRGEDGVIDIGGTGSKVIGLDGGKVVRFGGNGQCAGGEGSFLEIAARALGAVV 156

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501835832  163 LAHDSVSRPSPLTETlmtefegdpervvefahaAKPKDFARYAPMVFEYAEKSDAVAVDIVKTAVNAIAQSLDALL--WP 240
Cdd:pfam01869 157 RELDGLAPKTTLNKG------------------AINSTCAVFAEQVVINALSGGETAEDILAGAARSIALRVAALAkrLG 218

                         250
                  ....*....|....*.
gi 501835832  241 DCP-SICLLGGLSKAY 255
Cdd:pfam01869 219 FVPdEVVLTGGVAKNA 234
 
Name Accession Description Interval E-value
ASKHA_NBD_GspK-like cd24082
nucleotide-binding domain (NBD) of Vibrio cholerae glucosamine kinase GspK and similar ...
 6-281 1.38e-102

nucleotide-binding domain (NBD) of Vibrio cholerae glucosamine kinase GspK and similar proteins; The family includes a group of uncharacterized proteins similar to Vibrio cholerae glucosamine kinase GspK (EC 2.7.1.8), also called GlcN kinase. It acts as ATP-dependent kinase, which is specific for glucosamine. GspK does not show kinase activity with any other sugar.


Pssm-ID: 466932 [Multi-domain]  Cd Length: 279  Bit Score: 300.99  E-value: 1.38e-102
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501835832   6 IGIDGGGTSCRAAVTDRTGKILGAGKAGASNILSDLENSRNNVVASARQALVDAGLDPGLTDKLPAVIGTAGANVGDYGK 85
Cdd:cd24082    3 IGIDGGGTKCRARLADADGTVLGEATGGPANLSSDLDQAWASILAAIKQALAQAGLDAAALSDLHAGLGLAGANVPEARA 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501835832  86 RLEKALP-FATVHVVTDAAIALQGALGDADGIIGAFGTGSVYNARRDGKSWGIGGWGFVVGDQASGARLGRDLLERSILA 164
Cdd:cd24082   83 AFLAALPpFASLVVVSDAHIACLGAHGGEDGAIIILGTGSVGAALDGGEVRQVGGWGFPLGDEGSGAWLGLRALRHTLLA 162

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501835832 165 HDSVSRPSPLTETLMTEFEGDPERVVEFAHAAKPKDFARYAPMVFEYAEKSDAVAVDIVKTAVNAIAQSLDALLWPDCPS 244
Cdd:cd24082  163 LDGLAPSSPLTRAVLARFGGDPAEIVAWANTATPADFAALAPLVFEAAEQGDPVALAILQEAAAYIERLLRALGAQGALP 242

                        250       260       270
                 ....*....|....*....|....*....|....*..
gi 501835832 245 ICLLGGLSKAYYPWLDTRYKALLREPKGDALSGAIEL 281
Cdd:cd24082  243 LCLLGGLAERLAPYLPEDLQARLVPPKGDALDGALLL 279
BadF COG2971
BadF-type ATPase, related to human N-acetylglucosamine kinase [Carbohydrate transport and ...
 6-286 5.86e-72

BadF-type ATPase, related to human N-acetylglucosamine kinase [Carbohydrate transport and metabolism];


Pssm-ID: 442210 [Multi-domain]  Cd Length: 298  Bit Score: 223.60  E-value: 5.86e-72
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501835832   6 IGIDGGGTSCRAAVTDRTGKILGAGKAGASNILS-DLENSRNNVVASARQALVDAGLDPGLTdklPAVIGTAGANVGDYG 84
Cdd:COG2971    4 LGVDGGGTKTRAVLVDADGEVLGRGRAGGANPQSvGLEEALASLREALEEALAAAGDPADIE---AVGFGLAGAGTPEDA 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501835832  85 KRLEKAL----PFATVHVVTDAAIALQGALGDADGIIGAFGTGSVYNARR-DGKSWGIGGWGFVVGDQASGARLGRDLLE 159
Cdd:COG2971   81 EALEAALrelfPFARVVVVNDALAALAGALGGEDGIVVIAGTGSIAAGRDgDGRTARVGGWGYLLGDEGSGAWLGREALR 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501835832 160 RSILAHDSVSRPSPLTETLMTEFEGD-PERVVEFAHA--AKPKDFARYAPMVFEYAEKSDAVAVDIVKTAVNAIAQSLDA 236
Cdd:COG2971  161 AALRALDGRGPPTALTEAVLAEFGLDdPEELIAWVYRgpAPPADLASLAPLVFEAAEAGDPVARAILEEAADELAELARA 240

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 501835832 237 LLWPDCPSICLLGGLSKAyYPWLDTRYKALL-------REPKGDALSGAIELAAKLL 286
Cdd:COG2971  241 LLERGALPVVLAGGVAAA-QPLLREALRARLaaggaeiVPPAGDPVDGALLLALRLL 296
ASKHA_NBD_eukNAGK-like cd24007
nucleotide-binding domain (NBD) of the eukaryotic-type N-acetylglucosamine kinase (NAGK) ...
 6-281 1.52e-47

nucleotide-binding domain (NBD) of the eukaryotic-type N-acetylglucosamine kinase (NAGK) family; The eukaryotic-type NAGK-like family includes a group of proteins similar to eukaryotic N-acetyl-D-glucosamine kinases, such as Vibrio cholerae glucosamine kinase GspK, Sulfurisphaera tokodaii ATP-dependent hexokinase (StHK), Thermoplasma acidophilum 2-dehydro-3-deoxygluconokinase (KdgK) and Clostridium acetobutylicum N-acetylmuramic acid/N-acetylglucosamine kinase (MurK). NAGK (EC 2.7.1.59), also called GlcNAc kinase, converts endogenous N-acetylglucosamine (GlcNAc), a major component of complex carbohydrates, from lysosomal degradation or nutritional sources into GlcNAc 6-phosphate. It is involved in the N-glycolylneuraminic acid (Neu5Gc) degradation pathway. NAGK also has ManNAc kinase activity. GspK (EC 2.7.1.8), also called GlcN kinase, acts as ATP-dependent kinase, which is specific for glucosamine. StHK is a novel hexokinase that can phosphorylate not only glucose but also GlcNAc, glucosamine, and mannose. KdgK (EC 2.7.1.45), also called 2-keto-3-deoxy-D-gluconate kinase, or KDG kinase, catalyzes the phosphorylation of 2-keto-3-deoxygluconate (KDG) to produce 2-keto-3-deoxy-6-phosphogluconate (KDPG). It is specific for KDG. MurK (EC 2.7.1.-/EC 2.7.1.59), also known MurNAc/GlcNAc kinase, or murein sugar kinase, catalyzes the ATP-dependent phosphorylation of both cell wall (peptidoglycan) amino sugars, N-acetylmuramic acid (MurNAc) and N-acetylglucosamine (GlcNAc), at the 6-hydroxyl group. The eukaryotic-type N-acetylglucosamine kinase (NAGK) family belongs to the ASKHA (Acetate and Sugar Kinases/Hsc70/Actin) superfamily, all members of which share a common characteristic five-stranded beta sheet occurring in both the N- and C-terminal domains.


Pssm-ID: 466857 [Multi-domain]  Cd Length: 295  Bit Score: 160.55  E-value: 1.52e-47
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501835832   6 IGIDGGGTSCRAAVTDRTGKILGAGKAGASNILS-DLENSRNNVVASARQALVDAGldpGLTDKLPAVIGTAGANVGDYG 84
Cdd:cd24007    2 LGVDGGGTKTRAVLADEDGKILGRGKGGPSNPASvGIEEAKENLKEAVREALSQAG---SLGEIDAICLGLAGIDSEEDR 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501835832  85 KRLEKAL----PFATVHVVTDAAIALQGALGDADGIIGAFGTGSV-YNARRDGKSWGIGGWGFVVGDQASGARLGRDLLE 159
Cdd:cd24007   79 ERLRSALkelfLSGRIIIVNDAEIALAAALGGGPGIVVIAGTGSVaYGRNGDGEEARVGGWGHLLGDEGSGYWIGRRALR 158

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501835832 160 RSILAHDSVSRPSPLTETLMTEFE-GDPERVVEFAHAAK--PKDFARYAPMVFEYAEKSDAVAVDIVKTAVNAIAQSLDA 236
Cdd:cd24007  159 AALRALDGRGPKTPLLDAILKFLGlDSIEELITAIYRSSdrKKEIASLAPLVFEAAEEGDPVAQAILKEAAEELAKLVVA 238

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 501835832 237 L----LWPDCPSICLLGGLSKAYYPWLDTRYKALLR--------EPKGDALSGAIEL 281
Cdd:cd24007  239 LakllLLGEKLPLALSGGVFKNNYYLAEFLEELLKKkkpnakvvEPKGSPVVGALLL 295
ASKHA_NBD_MurK-like cd24084
nucleotide-binding domain (NBD) of Clostridium acetobutylicum N-acetylmuramic acid ...
 6-284 1.76e-33

nucleotide-binding domain (NBD) of Clostridium acetobutylicum N-acetylmuramic acid/N-acetylglucosamine kinase (MurK) and similar proteins; The family includes a group of uncharacterized proteins similar to Clostridium acetobutylicum N-acetylmuramic acid/N-acetylglucosamine kinase (MurK; EC 2.7.1.-/EC 2.7.1.59), also known MurNAc/GlcNAc kinase, or murein sugar kinase. It catalyzes the ATP-dependent phosphorylation of both cell wall (peptidoglycan) amino sugars, N-acetylmuramic acid (MurNAc) and N-acetylglucosamine (GlcNAc), at the 6-hydroxyl group. Neither the non-N-acetylated forms of the cell wall sugars, i.e., glucosamine and/or muramic acid, nor epimeric hexoses or 1,6-anhydro-MurNAc are substrates for the enzyme. MurK may have a role in the rescue of the murein sugars GlcNAc and MurNAc released from muropeptides during cell wall turnover in C.acetobutylicum.


Pssm-ID: 466934 [Multi-domain]  Cd Length: 302  Bit Score: 124.01  E-value: 1.76e-33
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501835832   6 IGIDGGGTSCRAAVTDRTGKILGAGKAGASNILSdleNSRNNVVASARQALVD--AGLDPGLTDKLPAVIGTAGANVGDY 83
Cdd:cd24084    4 IGIDGGGTKTHLKITDLNGNVVGEGFGGSSNLES---NSLETVRENLKELFQDfyEQLGKSLKECGSICLGTAGASHQGA 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501835832  84 GKRLEKAL----PFATVHVVTDAAIALQGALGDADGIIGAFGTGSV-YNARRDGKSWGIGGWGFVVGDQASGARLGRDLL 158
Cdd:cd24084   81 KETLKDILtelgPDAKIEVVNDAEIALAAGLEGKPGIVLISGTGSIcYGRNTDGETARAGGWGHLLGDEGSGYWIAMQAL 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501835832 159 ERSILAHDSVSRPSPLTETLMTEFE-GDPERVVEFAHAAK--PKDFARYAPMVFEYAEKSDAVAVDIVKTAVNAIAQSLD 235
Cdd:cd24084  161 GAVLQAFDGRGPKTILTELLLEELKlSSPRELIDFIYSSDadKKEIASLARLVDEAADQGDEVAKEILEEAARELARLAI 240

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 501835832 236 A----LLWPDCPSICLLGG--------LSKAYYPWLDTRY-KALLREPKGDALSGAIELAAK 284
Cdd:cd24084  241 AvaqkLLMKPKDFVVILGGsvlenccvLRSKLSALILTKYpNAIVGLLKHDAAYGAVKLARE 302
ASKHA_NBD_KdgK-like cd24083
nucleotide-binding domain (NBD) of Thermoplasma acidophilum 2-dehydro-3-deoxygluconokinase ...
 6-254 1.74e-30

nucleotide-binding domain (NBD) of Thermoplasma acidophilum 2-dehydro-3-deoxygluconokinase (KdgK) and similar proteins; The family includes a group of uncharacterized proteins similar to Thermoplasma acidophilum 2-dehydro-3-deoxygluconokinase (KdgK; EC 2.7.1.45), also called 2-keto-3-deoxy-D-gluconate kinase, or KDG kinase. It catalyzes the phosphorylation of 2-keto-3-deoxygluconate (KDG) to produce 2-keto-3-deoxy-6-phosphogluconate (KDPG). It is specific for KDG.


Pssm-ID: 466933 [Multi-domain]  Cd Length: 284  Bit Score: 115.95  E-value: 1.74e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501835832   6 IGIDGGGTSCRAAVTD-RTGKILGAGKAGASNILS-DLENSRNNVVASARQALVDAGLDPglTDKlpAVIGTAGAnvGD- 82
Cdd:cd24083    2 LGVDGGGTKTLAVLFDeRQGEIVGIGISGPSNFTVvGRETARKNISDAINDALSDAGMDS--IDK--ATFGLAGI--GDs 75

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501835832  83 -----YGKRLEKALPfATVHVVTDAAIALQGALGDADGIIGAFGTGSVYNARRDGKSWGIGGWGFVVGDQASGARLGRDL 157
Cdd:cd24083   76 yeatiMGEEIIRSGL-KKFDIYNDGEAAYYSGNGDDDGIVFAPGTGSVGYIKDEGRVNRIGGWGWSLGDEGSAFWIAKQA 154

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501835832 158 LERSILAHDSVSRPSPLTETLMTEFeGDPER--VVEFAHAAKPKDFARYAPMVFEYAEKSDAVAVDIVKTAVNAIAQSLD 235
Cdd:cd24083  155 IEAAMREMDGREEWTSLVVEVEKEF-KLSLRelVINISYEGIKRLVASLAKLVSQLAEKGDPVALAIFDEAASEIKKIIN 233

                        250       260
                 ....*....|....*....|.
gi 501835832 236 ALL--WPDCPSICLLGGLSKA 254
Cdd:cd24083  234 AHRlnFGPPIRVSLVGGVMQS 254
BcrAD_BadFG pfam01869
BadF/BadG/BcrA/BcrD ATPase family; This family includes the BadF and BadG proteins that are ...
 6-255 4.88e-22

BadF/BadG/BcrA/BcrD ATPase family; This family includes the BadF and BadG proteins that are two subunits of Benzoyl-CoA reductase, that may be involved in ATP hydrolysis. The family also includes an activase subunit from the enzyme 2-hydroxyglutaryl-CoA dehydratase. The protein Swiss:O66634 contains two copies of this region suggesting that the family may structurally dimerize. This family appears to be related to pfam00370.


Pssm-ID: 396441 [Multi-domain]  Cd Length: 271  Bit Score: 92.80  E-value: 4.88e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501835832    6 IGIDGGGTSCRAAVTDRTGKILGAGKAGASNILS-DLENSRNNVVASARQALVDAGLDPGLTDklpaVIGTAGANVGDYG 84
Cdd:pfam01869   1 LGIDGGSTKTKAVLMDDDGEVLGRAIAGSANFESvGVEAAERNLKDAITEALEEAGLKLDDIE----YMFLGLTGYGRAG 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501835832   85 --KRLEKALPFATVHVVTDAAIALQGALGDADGIIGAFGTGSVYNARRDGKSWGIGGWGFVVGDQASGARLGRDLLERSI 162
Cdd:pfam01869  77 vdGHFGKDIVREEITVHADGAVALAPGTRGEDGVIDIGGTGSKVIGLDGGKVVRFGGNGQCAGGEGSFLEIAARALGAVV 156

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501835832  163 LAHDSVSRPSPLTETlmtefegdpervvefahaAKPKDFARYAPMVFEYAEKSDAVAVDIVKTAVNAIAQSLDALL--WP 240
Cdd:pfam01869 157 RELDGLAPKTTLNKG------------------AINSTCAVFAEQVVINALSGGETAEDILAGAARSIALRVAALAkrLG 218

                         250
                  ....*....|....*.
gi 501835832  241 DCP-SICLLGGLSKAY 255
Cdd:pfam01869 219 FVPdEVVLTGGVAKNA 234
ASKHA_NBD_StHK-like cd24080
nucleotide-binding domain (NBD) of Sulfurisphaera tokodaii ATP-dependent hexokinase (StHK) and ...
 6-237 1.59e-21

nucleotide-binding domain (NBD) of Sulfurisphaera tokodaii ATP-dependent hexokinase (StHK) and similar proteins; The family includes a group of uncharacterized proteins similar to Sulfurisphaera tokodaii ATP-dependent hexokinase (StHK). Hexokinase (EC 2.7.1.1) catalyzes the phosphorylation of glucose to glucose 6-phosphate by using ATP as a phosphoryl donor. StHK is a novel hexokinase that can phosphorylate not only glucose but also GlcNAc, glucosamine, and mannose. It differs from other known hexokinases and glucokinases in that its activity is strongly inhibited by ADP. It is distinct in its broad substrate specificity from the GlcNAc kinases, which are specific for GlcNAc.


Pssm-ID: 466930 [Multi-domain]  Cd Length: 291  Bit Score: 91.72  E-value: 1.59e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501835832   6 IGIDGGGTSCRAAVTDRTGKILGAGKAGASNI-LSDLENSRNNVVASARQALVDAGLDpgltdklPAVIGTAGAN-VGDY 83
Cdd:cd24080    4 LGVDGGGTKTEAVAYDCKGRFLGYGLAGPGNIhNVGLESAIENVKEAVKRALKGGRAD-------VAVLGFAGADsKKDW 76

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501835832  84 GKRLE--KALPFATVHVVTDAAIALQGALGDADGIIGAFGTGSV---YNARrdGKSWGIGGWGFVVGDQASGARLGRDLL 158
Cdd:cd24080   77 EKFTEllSKIIAKKVIVQHDGEIALIAETRGSPGVMVIAGTGSIvegYDGR--GRVVRVGGWGWLLGDEGSGYWIGREAL 154

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501835832 159 ERSILAHDSVSRPSPLTETLMTEFE-GDPERVVEFAHAAK--PKDFARYAPMVFEYAEKSDAVAVDIVKTAVNAIAQSLD 235
Cdd:cd24080  155 RALLRMLDGRENKTILAEKVLKTLNvEDFDELVEWIYSSLcpVDLIASLAKAVDEAAEEGDTVARDILKRAAEELASAAV 234


                 ..
gi 501835832 236 AL 237
Cdd:cd24080  235 AL 236
ASKHA_NBD_DdNAGK-like cd24081
nucleotide-binding domain (NBD) of Dictyostelium discoideum N-acetyl-D-glucosamine kinase ...
 6-236 4.55e-20

nucleotide-binding domain (NBD) of Dictyostelium discoideum N-acetyl-D-glucosamine kinase (NAGK) and similar proteins; The family includes a group of uncharacterized proteins similar to Dictyostelium discoideum N-acetyl-D-glucosamine kinase (NAGK). NAGK (EC 2.7.1.59), also called N-acetylglucosamine kinase, or GlcNAc kinase, converts N-acetylglucosamine (GlcNAc), a major component of complex carbohydrates, into GlcNAc 6-phosphate. It also has ManNAc kinase activity.


Pssm-ID: 466931 [Multi-domain]  Cd Length: 311  Bit Score: 88.14  E-value: 4.55e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501835832   6 IGIDGGGTSCR-----AAVTDRTGKILGAGKAGASNILS-DLENSRNNVVASARQALVDAGLdpGLTDKLPAVIGTAGAN 79
Cdd:cd24081    2 LGIDGGGTKTTcvavdAATLGDNLLVLGRAVAGSSNYNSvGEEAARRAIEEAIAGALKQAGV--PRSAVRAVCLGISGVD 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501835832  80 VGDYGKRLEKAL-----PFATVHVVTDAAIAL-QGALGDADGIIGAFGTGSV-YNARRDGKSWGIGGWGFVVGDQASGAR 152
Cdd:cd24081   80 RPADAERVRSWLrelfpENVKVFVFNDAVAALaSGTAGKLHGCVLIAGTGTIaYGFNEDGKRARAGGWGPLLGDRGSGHA 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501835832 153 LGRDLLERSILAHDSVSRPSPLTETLMTEFEGD-PERVVEFAHaaKPKDFARYA---PMVFEYAEKSDAVAVDIVKTAVN 228
Cdd:cd24081  160 IGSQALTAVMRAEDGRGPPTSLTGAILKKLGLSsPDDLIGWAY--DDTSWARVAalvPLVKACAAAGDAVALGILEDAAE 237


                 ....*...
gi 501835832 229 AIAQSLDA 236
Cdd:cd24081  238 ELALSVKA 245
ASKHA_NBD_PG1100-like cd24079
nucleotide-binding domain (NBD) of Porphyromonas gingivalis putative N-acetylglucosamine ...
 9-269 1.37e-13

nucleotide-binding domain (NBD) of Porphyromonas gingivalis putative N-acetylglucosamine kinase (PG1100) and similar proteins; The family includes a group of uncharacterized proteins similar to Porphyromonas gingivalis putative N-acetylglucosamine kinase (PG1100; EC 2.7.1.59), which may convert GlcNAc to GlcNAc-6-phosphate, a component utilized in UDP-GlcNAc biosynthesis or energy metabolism.


Pssm-ID: 466929 [Multi-domain]  Cd Length: 276  Bit Score: 69.16  E-value: 1.37e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501835832   9 DGGGTSCRAAVTDRTGKILGAGKAGAS-NILSDLEnsrnnvVASARQALvdagLDPGLTDKLPAVI---GtAGANVGDYG 84
Cdd:cd24079    5 DSGGTKTDWALVDGGGVIKQFTTKGLNpFFLSDEE------IEQILALV----LLPLLEESKIEEVyfyG-AGCGSPERA 73

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501835832  85 KRLEKAL----PFATVHVVTD---AAIALqgaLGDADGIIGAFGTGSVYnARRDGKSW--GIGGWGFVVGDQASGARLGR 155
Cdd:cd24079   74 ARIKRLLkkvfPKAEIEVKSDllgAARAL---CGDKKGIVCILGTGSNS-CYYDGEKIhdQRPGLGYLLGDEGSGAYLGK 149

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501835832 156 DLLeRSILAHDSvsrPSPLTETLMTEFEGDPERVVE-FAHAAKPKDF-ARYAPMVFEYAEksDAVAVDIVKTAVNAIAQS 233
Cdd:cd24079  150 LLL-RDYLYGQL---PEELRKRFEEQFGLNKEEILSrVYRSPDPNRYlASLSRFIAEHLE--HPYIRELIRESFREFFET 223

                        250       260       270
                 ....*....|....*....|....*....|....*...
gi 501835832 234 LDaLLWPDCPS--ICLLGglSKAYYpwldtrYKALLRE 269
Cdd:cd24079  224 HV-LPYPDYKTlpIHFVG--SVAFY------FKDILRE 252
ASKHA_NBD_NAGK_meta cd24078
nucleotide-binding domain (NBD) of N-acetyl-D-glucosamine kinase (NAGK) and similar proteins; ...
 6-150 2.01e-09

nucleotide-binding domain (NBD) of N-acetyl-D-glucosamine kinase (NAGK) and similar proteins; NAGK (EC 2.7.1.59), also called N-acetylglucosamine kinase, or GlcNAc kinase, converts endogenous N-acetylglucosamine (GlcNAc), a major component of complex carbohydrates, from lysosomal degradation or nutritional sources into GlcNAc 6-phosphate. It is involved in the N-glycolylneuraminic acid (Neu5Gc) degradation pathway. NAGK also has ManNAc kinase activity. Members in this family are mainly from metazoa.


Pssm-ID: 466928 [Multi-domain]  Cd Length: 314  Bit Score: 57.59  E-value: 2.01e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501835832   6 IGIDGGGTSCRAAVTDRTGKILGAGKAGASNI-LSDLENSRNNVVASARQALVDAGLDPglTDKLPAV-IGTAGANVGDY 83
Cdd:cd24078    3 GGVEGGATHSKLVIMDEDGKILAESEGPGTNHwLIGLDECAKRINEMVQEAKKKAGLDP--DTPLKSLgLSLSGAEQEEA 80

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 501835832  84 GKRLEKAL------PFATVHVVTDAAIALQGALgDADGIIGAFGTGSvyNAR---RDGKSWGIGGWGFVVGDQASG 150
Cdd:cd24078   81 QEELIEGLrsrypnLSESYYVTSDTVGAIATAF-ENGGIVLISGTGS--NCQlinPDGSTAGCGGWGHMLGDEGSA 153
NagC COG1940
Sugar kinase of the NBD/HSP70 family, may contain an N-terminal HTH domain [Carbohydrate ...
 1-260 2.01e-03

Sugar kinase of the NBD/HSP70 family, may contain an N-terminal HTH domain [Carbohydrate transport and metabolism, Transcription];


Pssm-ID: 441543 [Multi-domain]  Cd Length: 306  Bit Score: 39.11  E-value: 2.01e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501835832   1 MAEFSIGIDGGGTSCRAAVTDRTGKILGAGKAgASNILSDLENSRNNVVASARQALVDAGLD-----------PGLTDKL 69
Cdd:COG1940    3 DAGYVIGIDIGGTKIKAALVDLDGEVLARERI-PTPAGAGPEAVLEAIAELIEELLAEAGISrgrilgigigvPGPVDPE 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501835832  70 PAVIGTAGANVG----DYGKRLEKALPFaTVHVVTDA-AIAL----QGALGDADGIIG-AFGTgsvynarrdgkswGIGG 139
Cdd:COG1940   82 TGVVLNAPNLPGwrgvPLAELLEERLGL-PVFVENDAnAAALaeawFGAGRGADNVVYlTLGT-------------GIGG 147

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501835832 140 wGFVV------GDQASGARLGrdllersilaHDSVSRPSPLTETLMTefeGDPERVV-------EFAHAAKPKDFAryAP 206
Cdd:COG1940  148 -GIVIngkllrGANGNAGEIG----------HMPVDPDGPLCGCGNR---GCLETYAsgpallrRARELGGAEKLT--AE 211

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 501835832 207 MVFEYAEKSDAVAVDIVKTAVNAIAQSLDALLW---PDCpsICLLGGLSKAYYPWLD 260
Cdd:COG1940  212 ELFAAARAGDPLALEVLDEAARYLGIGLANLINlldPEV--IVLGGGVSAAGDLLLE 266
ASKHA_NBD_ROK_AlsK cd24070
nucleotide-binding domain (NBD) of D-allose kinase (AlsK) and similar proteins; AlsK (EC 2.7.1. ...
 6-123 3.93e-03

nucleotide-binding domain (NBD) of D-allose kinase (AlsK) and similar proteins; AlsK (EC 2.7.1.55), also called allokinase, catalyzes the phosphorylation of D-allose to D-allose 6-phosphate. It has also low level glucokinase activity in vitro. Members of this subfamily belong to the kinase (ROK) family, a group of proteins that have sugar kinase and/or transcriptional repressor activities.


Pssm-ID: 466920 [Multi-domain]  Cd Length: 293  Bit Score: 38.30  E-value: 3.93e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501835832   6 IGIDGGGTSCRAAVTDRTGKILGAGKAGASNILSDlENSRNNVVASARQALVDAGLD--------PGLTDK-LPAVIGT- 75
Cdd:cd24070    4 LGIDIGGTNIRIGLVDEDGKLLDFEKVPSKDLLRA-GDPVEVLADLIREYIEEAGLKpaaivigvPGTVDKdRRTVISTp 82

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 501835832  76 --AGANVGDYGKRLEKALPFaTVHVVTDAAIAL-----QGALGDADGIIGA-FGTG 123
Cdd:cd24070   83 niPGLDGVNLADILENKLGI-PVILERDVNLLLlydmrAGNLDDEGVVLGFyIGTG 137
XylB COG1070
Sugar (pentulose or hexulose) kinase [Carbohydrate transport and metabolism]; Sugar (pentulose ...
 6-64 5.05e-03

Sugar (pentulose or hexulose) kinase [Carbohydrate transport and metabolism]; Sugar (pentulose or hexulose) kinase is part of the Pathway/BioSystem: Non-phosphorylated Entner-Doudoroff pathway


Pssm-ID: 440688 [Multi-domain]  Cd Length: 494  Bit Score: 38.27  E-value: 5.05e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 501835832   6 IGIDGGGTSCRAAVTDRTGKILGAGKAGASNILS-------DLENSRNNVVASARQALVDAGLDPG 64
Cdd:COG1070    4 LGIDIGTTSVKAVLFDADGEVVASASAEYPLSSPhpgwaeqDPEDWWEAVVEAIRELLAKAGVDPE 69
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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