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Conserved domains on  [gi|502108611|ref|WP_012711584|]
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type II toxin-antitoxin system VapC family toxin [Sulfolobus islandicus]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PIN_VapC-like cd18689
uncharacterized subfamily of the VapC-like nuclease family of the PIN domain superfamily; VapC ...
 2-124 1.99e-25

uncharacterized subfamily of the VapC-like nuclease family of the PIN domain superfamily; VapC is the PIN-domain ribonuclease toxin from prokaryotic VapBC toxin-antitoxin (TA) systems. VapB is a transcription factor-like protein antitoxin acting as an inhibitor. Other members of the VapC-like nuclease family include FitB toxin of the FitAB TA system, eukaryotic ribonucleases such as Smg6, ribosome assembly factor NOB1, exosome subunit Rrp44 endoribonuclease and rRNA-processing protein Fcf1. The PIN domain belongs to a large nuclease superfamily. The structural properties of the PIN (PilT N terminus) domain indicate its active center, consisting of three highly conserved catalytic residues which coordinate metal ions, in some members, additional metal coordinating residues can be found. Some members of the superfamily lack several of these key catalytic residues. The PIN active site is geometrically similar in the active center of structure-specific 5' nucleases, PIN-domain ribonucleases of eukaryotic rRNA editing proteins, and bacterial toxins of toxin-antitoxin (TA) operons.


:

Pssm-ID: 350256  Cd Length: 125  Bit Score: 93.47  E-value: 1.99e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502108611   2 IVDTGVLIEYINEEGkyHEKVKKLIESNTS----LFVTPITLSEVLYVSYRVYraaGSNDANDYAKEFVEWLLsklKVTE 77
Cdd:cd18689    1 VLDSGALLAYFEGEP--HKVAKKLIELIKEgkaeLYISAINLGEVYYITARKK---GEEKAEEVLSLLLALPI---EVVE 72

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*..
gi 502108611  78 INHEIVIKAGEIKKKYGIALPDCYVIATADYLKdKALFKKEKEIVQA 124
Cdd:cd18689   73 ADEELVEAAAKIKAKYGLSYADCFALATAKELN-AALVTGDPEFKKV 118
 
Name Accession Description Interval E-value
PIN_VapC-like cd18689
uncharacterized subfamily of the VapC-like nuclease family of the PIN domain superfamily; VapC ...
 2-124 1.99e-25

uncharacterized subfamily of the VapC-like nuclease family of the PIN domain superfamily; VapC is the PIN-domain ribonuclease toxin from prokaryotic VapBC toxin-antitoxin (TA) systems. VapB is a transcription factor-like protein antitoxin acting as an inhibitor. Other members of the VapC-like nuclease family include FitB toxin of the FitAB TA system, eukaryotic ribonucleases such as Smg6, ribosome assembly factor NOB1, exosome subunit Rrp44 endoribonuclease and rRNA-processing protein Fcf1. The PIN domain belongs to a large nuclease superfamily. The structural properties of the PIN (PilT N terminus) domain indicate its active center, consisting of three highly conserved catalytic residues which coordinate metal ions, in some members, additional metal coordinating residues can be found. Some members of the superfamily lack several of these key catalytic residues. The PIN active site is geometrically similar in the active center of structure-specific 5' nucleases, PIN-domain ribonucleases of eukaryotic rRNA editing proteins, and bacterial toxins of toxin-antitoxin (TA) operons.


Pssm-ID: 350256  Cd Length: 125  Bit Score: 93.47  E-value: 1.99e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502108611   2 IVDTGVLIEYINEEGkyHEKVKKLIESNTS----LFVTPITLSEVLYVSYRVYraaGSNDANDYAKEFVEWLLsklKVTE 77
Cdd:cd18689    1 VLDSGALLAYFEGEP--HKVAKKLIELIKEgkaeLYISAINLGEVYYITARKK---GEEKAEEVLSLLLALPI---EVVE 72

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*..
gi 502108611  78 INHEIVIKAGEIKKKYGIALPDCYVIATADYLKdKALFKKEKEIVQA 124
Cdd:cd18689   73 ADEELVEAAAKIKAKYGLSYADCFALATAKELN-AALVTGDPEFKKV 118
VapC COG1848
VapC family ribonuclease, toxin component of the VapBC toxin-antitoxin module, contains PIN ...
 1-106 7.10e-20

VapC family ribonuclease, toxin component of the VapBC toxin-antitoxin module, contains PIN domain [Defense mechanisms];


Pssm-ID: 441453  Cd Length: 134  Bit Score: 79.25  E-value: 7.10e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502108611   1 MIVDTGVLIEYINEEGKYHEKVKKLIES----NTSLFVTPITLSEVLYVSYRVYRAAGSNdandyAKEFVEWLLSKLKVT 76
Cdd:COG1848    2 ILLDTNVLIYALEGDSPFHERARELLERaeegEEELYTSPLVLAEVLYVLTRPGGLSLEE-----ARELLEALLSNIEVV 76

                         90       100       110
                 ....*....|....*....|....*....|
gi 502108611  77 EINHEIVIKAGEIKKKYGIALPDCYVIATA 106
Cdd:COG1848   77 PVDEEILEEAAELLAKYGLRLNDALHLATA 106
PIN pfam01850
PIN domain;
1-114 9.45e-12

PIN domain;


Pssm-ID: 426475  Cd Length: 121  Bit Score: 58.19  E-value: 9.45e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502108611    1 MIVDTGVLIEYINEEgKYHEKVKKLIESNTSLFVTPITLSEVLYVSYRVYRAagsndanDYAKEFVEW--LLSKLKVTEI 78
Cdd:pfam01850   1 IVLDTSVLIALLRGE-PLHEAARELLEAAGELVTSAIVLAELLYGLNRRLGL-------GKAAELVELllLLSALEVLPI 72

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 502108611   79 NHEIVIKAGEIKKKYG-IALPDCYVIATADYLKDKAL 114
Cdd:pfam01850  73 DAELAEEAAELRLKYGkLGPNDALIAATAKEHGAKLI 109
 
Name Accession Description Interval E-value
PIN_VapC-like cd18689
uncharacterized subfamily of the VapC-like nuclease family of the PIN domain superfamily; VapC ...
 2-124 1.99e-25

uncharacterized subfamily of the VapC-like nuclease family of the PIN domain superfamily; VapC is the PIN-domain ribonuclease toxin from prokaryotic VapBC toxin-antitoxin (TA) systems. VapB is a transcription factor-like protein antitoxin acting as an inhibitor. Other members of the VapC-like nuclease family include FitB toxin of the FitAB TA system, eukaryotic ribonucleases such as Smg6, ribosome assembly factor NOB1, exosome subunit Rrp44 endoribonuclease and rRNA-processing protein Fcf1. The PIN domain belongs to a large nuclease superfamily. The structural properties of the PIN (PilT N terminus) domain indicate its active center, consisting of three highly conserved catalytic residues which coordinate metal ions, in some members, additional metal coordinating residues can be found. Some members of the superfamily lack several of these key catalytic residues. The PIN active site is geometrically similar in the active center of structure-specific 5' nucleases, PIN-domain ribonucleases of eukaryotic rRNA editing proteins, and bacterial toxins of toxin-antitoxin (TA) operons.


Pssm-ID: 350256  Cd Length: 125  Bit Score: 93.47  E-value: 1.99e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502108611   2 IVDTGVLIEYINEEGkyHEKVKKLIESNTS----LFVTPITLSEVLYVSYRVYraaGSNDANDYAKEFVEWLLsklKVTE 77
Cdd:cd18689    1 VLDSGALLAYFEGEP--HKVAKKLIELIKEgkaeLYISAINLGEVYYITARKK---GEEKAEEVLSLLLALPI---EVVE 72

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*..
gi 502108611  78 INHEIVIKAGEIKKKYGIALPDCYVIATADYLKdKALFKKEKEIVQA 124
Cdd:cd18689   73 ADEELVEAAAKIKAKYGLSYADCFALATAKELN-AALVTGDPEFKKV 118
VapC COG1848
VapC family ribonuclease, toxin component of the VapBC toxin-antitoxin module, contains PIN ...
 1-106 7.10e-20

VapC family ribonuclease, toxin component of the VapBC toxin-antitoxin module, contains PIN domain [Defense mechanisms];


Pssm-ID: 441453  Cd Length: 134  Bit Score: 79.25  E-value: 7.10e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502108611   1 MIVDTGVLIEYINEEGKYHEKVKKLIES----NTSLFVTPITLSEVLYVSYRVYRAAGSNdandyAKEFVEWLLSKLKVT 76
Cdd:COG1848    2 ILLDTNVLIYALEGDSPFHERARELLERaeegEEELYTSPLVLAEVLYVLTRPGGLSLEE-----ARELLEALLSNIEVV 76

                         90       100       110
                 ....*....|....*....|....*....|
gi 502108611  77 EINHEIVIKAGEIKKKYGIALPDCYVIATA 106
Cdd:COG1848   77 PVDEEILEEAAELLAKYGLRLNDALHLATA 106
PIN pfam01850
PIN domain;
1-114 9.45e-12

PIN domain;


Pssm-ID: 426475  Cd Length: 121  Bit Score: 58.19  E-value: 9.45e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502108611    1 MIVDTGVLIEYINEEgKYHEKVKKLIESNTSLFVTPITLSEVLYVSYRVYRAagsndanDYAKEFVEW--LLSKLKVTEI 78
Cdd:pfam01850   1 IVLDTSVLIALLRGE-PLHEAARELLEAAGELVTSAIVLAELLYGLNRRLGL-------GKAAELVELllLLSALEVLPI 72

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 502108611   79 NHEIVIKAGEIKKKYG-IALPDCYVIATADYLKDKAL 114
Cdd:pfam01850  73 DAELAEEAAELRLKYGkLGPNDALIAATAKEHGAKLI 109
COG2402 COG2402
Predicted nucleic acid-binding protein, contains PIN domain [General function prediction only]; ...
 2-115 9.31e-11

Predicted nucleic acid-binding protein, contains PIN domain [General function prediction only];


Pssm-ID: 441958  Cd Length: 135  Bit Score: 55.67  E-value: 9.31e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502108611   2 IVDTGVLIEYINEEGKYHEKVKKLIES----NTSLFVTPITLSEVLY-VSYRVYRAAgsndandyAKEFVEWLL--SKLK 74
Cdd:COG2402    3 FVDTGALIALFNRRDQYHEAAVELLESllegELPLVTTDYVLTETLTlLSRRLGREA--------AVKFLDRLResGGLE 74

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....
gi 502108611  75 VTEINHEIVIKAGEIKKKY---GIALPDCYVIATADYLKDKALF 115
Cdd:COG2402   75 IVPLTEEDFERALELFEKYadkPLSLTDASSVALMERLGIDEIL 118
VapC COG1487
Ribonuclease/mRNA interferase VapC, contains PIN domain [Defense mechanisms];
1-106 4.08e-09

Ribonuclease/mRNA interferase VapC, contains PIN domain [Defense mechanisms];


Pssm-ID: 441096  Cd Length: 128  Bit Score: 51.40  E-value: 4.08e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502108611   1 MIVDTGVLIEYINeeGKYHEKVKKLIE-SNTSLFVTPITLSEVLyvsyrvYRAAGSNDANDYAKefVEWLLSKLKVTEIN 79
Cdd:COG1487    1 YLLDTNVLIDLLR--GRPPAVLAWLAElEAGELAISAITLAELL------YGARRSPDAKRRAA--LEAFLEAFPVLPFD 70

                         90       100       110
                 ....*....|....*....|....*....|..
gi 502108611  80 HEIVIKAGEIKKKY-----GIALPDCYVIATA 106
Cdd:COG1487   71 AEAARRAGELRAALrragrPIGLADLLIAATA 102
PIN_VapC4-5_FitB-like cd18741
uncharacterized subgroup of the PIN_VapC4-5_FitB-like subfamily of the PIN domain superfamily; ...
 2-106 3.20e-08

uncharacterized subgroup of the PIN_VapC4-5_FitB-like subfamily of the PIN domain superfamily; The PIN_VapC4-5_FitB-like subfamily includes the Virulence associated protein C (VapC)-like PIN (PilT N terminus) domain of Mycobacterium tuberculosis VapC4 and VapC5 ribonuclease toxins of the VapBC toxin/antitoxin (TA) system, and Neisseria gonorrhoeae FitB toxin of the FitAB TA system. This subfamily belongs to the VapC-like family of the PIN domain nuclease superfamily. VapC is the PIN-domain ribonuclease toxin from prokaryotic VapBC toxin-antitoxin (TA) systems. VapB is a transcription factor-like protein antitoxin acting as an inhibitor. Other members of the VapC-like nuclease family include eukaryotic ribonucleases such as Smg6, ribosome assembly factor NOB1, exosome subunit Rrp44 endoribonuclease and rRNA-processing protein Fcf1. The structural properties of the PIN (PilT N terminus) domain indicate its active center, consisting of three highly conserved catalytic residues which coordinate metal ions, in some members, additional metal coordinating residues can be found. Some members of the superfamily lack several of these key catalytic residues. The PIN active site is geometrically similar in the active center of structure-specific 5' nucleases, PIN-domain ribonucleases of eukaryotic rRNA editing proteins, and bacterial toxins of toxin-antitoxin (TA) operons.


Pssm-ID: 350308  Cd Length: 120  Bit Score: 48.65  E-value: 3.20e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502108611   2 IVDTGVLIEYINEEGKYHEKVKKLIESNtsLFVTPITLSEVLyvsyrvyraAGSNDANDYAKefVEWLLSKLKVTEINHE 81
Cdd:cd18741    1 LLDTDILIDFLRGNPSAAEKLLELLGGN--LAISVITVAELY---------AGARNKKELEK--LEKLLSLFEVIPVDEE 67

                         90       100
                 ....*....|....*....|....*....
gi 502108611  82 IVIKAGEIKKKY----GIALPDCYVIATA 106
Cdd:cd18741   68 IAELAGELRRKYrkshGLGLPDALIAATA 96
PIN_MjVapC2-VapC6_like cd18677
VapC-like PIN domain of Methanocaldococcus jannaschii VapC2, and VapC6, and related proteins; ...
 3-108 4.39e-08

VapC-like PIN domain of Methanocaldococcus jannaschii VapC2, and VapC6, and related proteins; This subfamily includes Methanocaldococcus jannaschii VapC2 and VapC6. It belongs to the VapC (virulence-associated protein C)-like family of the PIN domain nuclease superfamily. VapC is the PIN-domain ribonuclease toxin from prokaryotic VapBC toxin-antitoxin (TA) systems. VapB is a transcription factor-like protein antitoxin acting as an inhibitor. Other members of the VapC-like nuclease family include FitB toxin of the FitAB TA system, eukaryotic ribonucleases such as Smg6, ribosome assembly factor NOB1, exosome subunit Rrp44 endoribonuclease and rRNA-processing protein Fcf1. The structural properties of the PIN (PilT N terminus) domain indicate its active center, consisting of three highly conserved catalytic residues which coordinate metal ions, in some members, additional metal coordinating residues can be found. Some members of the superfamily lack several of these key catalytic residues. The PIN active site is geometrically similar in the active center of structure-specific 5' nucleases, PIN-domain ribonucleases of eukaryotic rRNA editing proteins, and bacterial toxins of toxin-antitoxin (TA) operons.


Pssm-ID: 350244  Cd Length: 136  Bit Score: 48.73  E-value: 4.39e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502108611   3 VDTGVLIEYIneegKYHEKVKKLIESNTS---LFVTPITLSEVLYV------SYRVYRAAGSNDANDYAKEFVEW-LLSK 72
Cdd:cd18677    2 IDSNVFIEYL----KGNELAKELLEKLENefeLFINPIVFSEVLYVylrlktGKSPYTLKKKPEIIEKLELEDVLeLLEL 77

                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 502108611  73 LKVTEINHEIVIKAGEIKKKYGIaLP-DCYVIATADY 108
Cdd:cd18677   78 FKILEINEEILELALELIEKYGL-LPnDALILATCKY 113
PIN_VapC4-5_FitB-like cd18738
uncharacterized subgroup of the PIN_VapC4-5_FitB-like subfamily of the PIN domain superfamily; ...
 2-106 1.26e-07

uncharacterized subgroup of the PIN_VapC4-5_FitB-like subfamily of the PIN domain superfamily; The PIN_VapC4-5_FitB-like subfamily includes the Virulence associated protein C (VapC)-like PIN (PilT N terminus) domain of Mycobacterium tuberculosis VapC4 and VapC5 ribonuclease toxins of the VapBC toxin/antitoxin (TA) system, and Neisseria gonorrhoeae FitB toxin of the FitAB TA system. This subfamily belongs to the VapC-like family of the PIN domain nuclease superfamily. VapC is the PIN-domain ribonuclease toxin from prokaryotic VapBC toxin-antitoxin (TA) systems. VapB is a transcription factor-like protein antitoxin acting as an inhibitor. Other members of the VapC-like nuclease family include eukaryotic ribonucleases such as Smg6, ribosome assembly factor NOB1, exosome subunit Rrp44 endoribonuclease and rRNA-processing protein Fcf1. The structural properties of the PIN (PilT N terminus) domain indicate its active center, consisting of three highly conserved catalytic residues which coordinate metal ions, in some members, additional metal coordinating residues can be found. Some members of the superfamily lack several of these key catalytic residues. The PIN active site is geometrically similar in the active center of structure-specific 5' nucleases, PIN-domain ribonucleases of eukaryotic rRNA editing proteins, and bacterial toxins of toxin-antitoxin (TA) operons.


Pssm-ID: 350305  Cd Length: 118  Bit Score: 47.14  E-value: 1.26e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502108611   2 IVDTGVLIEYINeeGKYHEKVKKLIESNTSLFVTPITLSEVLyvsyrvyraaGSNDANDYAKEFVEWLLSKLKVTEINHE 81
Cdd:cd18738    1 LLDTNIIIYYLK--GELPESLEELLEELNEPAISVITKIELL----------GWPKLTPEEEEEIEDFLSLAEVIPLDDE 68

                         90       100
                 ....*....|....*....|....*
gi 502108611  82 IVIKAGEIKKKYGIALPDCYVIATA 106
Cdd:cd18738   69 IARKTIELRKQYKIKLPDAIIAATA 93
PIN_MtVapC3-like cd18759
uncharacterized subgroup of the VapC3-like nuclease subfamily of the PIN domain superfamily; ...
 2-106 2.04e-07

uncharacterized subgroup of the VapC3-like nuclease subfamily of the PIN domain superfamily; The VapC3-like nuclease subfamily includes the Virulence associated protein C (VapC)-like PIN (PilT N terminus) domain of various Mycobacterium tuberculosis VapC toxins including VapC3, VapC11, VapC15, VapC21, VapC25, VapC28, VapC29, VapC30, VapC32, VapC33, VapC37, and VapC39. It belongs to the VapC-like family of the PIN domain nuclease superfamily. VapC is a PIN-domain ribonuclease toxin from prokaryotic VapBC toxin-antitoxin (TA) systems. VapB is a transcription factor-like protein antitoxin acting as an inhibitor. Other members of the VapC-like nuclease family include FitB toxin of the FitAB TA system, eukaryotic ribonucleases such as Smg6, ribosome assembly factor NOB1, exosome subunit Rrp44 endoribonuclease and rRNA-processing protein Fcf1. The structural properties of the PIN domain indicate its active center, consisting of three highly conserved catalytic residues which coordinate metal ions; in some members, additional metal coordinating residues can be found while some others lack several of these key catalytic residues. The PIN active site is geometrically similar in the active center of structure-specific 5' nucleases, PIN-domain ribonucleases of eukaryotic rRNA editing proteins, and bacterial toxins of toxin-antitoxin (TA) operons.


Pssm-ID: 350326  Cd Length: 126  Bit Score: 46.81  E-value: 2.04e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502108611   2 IVDTGVLIEYINE-EGKYHEKVKKLIESNtSLFVTPITLSEVLYvsyrvyraaGSNDANDYakEFVEWLLSKLKVTEINH 80
Cdd:cd18759    1 LVDTSVWIEFFRGkSSPVSEVVDELLDED-EVCTCGIVLAELLQ---------GAKSEKEL--SLLEDFLSALPYLPITD 68

                         90       100       110
                 ....*....|....*....|....*....|.
gi 502108611  81 EIVIKAGEI-----KKKYGIALPDCYVIATA 106
Cdd:cd18759   69 ELWIKAGELsfslrKKGITIPLSDLYIAALA 99
PIN_MtVapC26-like cd18696
VapC-like PIN domain of Mycobacterium tuberculosis VapC26 and related proteins; Mycobacterium ...
 2-121 6.36e-07

VapC-like PIN domain of Mycobacterium tuberculosis VapC26 and related proteins; Mycobacterium tuberculosis VapC26 cleaves 23S rRNA in the Sarcin-Ricin Loop, it is inhibited by the cognate VapB26 antitoxin. This subfamily belongs to the VapC (virulence-associated protein C)-like nuclease family of the PIN domain-like superfamily. VapC is the PIN-domain ribonuclease toxin from prokaryotic VapBC toxin-antitoxin (TA) systems. VapB is a transcription factor-like protein antitoxin acting as an inhibitor. Other members of the VapC-like nuclease family include FitB toxin of the FitAB TA system, eukaryotic ribonucleases such as Smg6, ribosome assembly factor NOB1, exosome subunit Rrp44 endoribonuclease and rRNA-processing protein Fcf1. The PIN domain belongs to a large nuclease superfamily. The structural properties of the PIN (PilT N terminus) domain indicate its active center, consisting of three highly conserved catalytic residues which coordinate metal ions, in some members, additional metal coordinating residues can be found. Some members of the superfamily lack several of these key catalytic residues. The PIN active site is geometrically similar in the active center of structure-specific 5' nucleases, PIN-domain ribonucleases of eukaryotic rRNA editing proteins, and bacterial toxins of toxin-antitoxin (TA) operons.


Pssm-ID: 350263  Cd Length: 132  Bit Score: 45.64  E-value: 6.36e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502108611   2 IVDTGVLIEYINEEGKYHEKVKKLIESNT-SLFVTPITLSEVLYVSYRVYraagsndANDYAKEFVEWLLSK-LKVTEIN 79
Cdd:cd18696    1 IIDTGALLALFDAADPDHAAVRECIQRSAdALVVSPYVVTELDYLLATRV-------GNDAELAVLQELAGGaFELANCG 73

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|..
gi 502108611  80 HEIVIKAGEIKKKYG---IALPDCYVIA------TADYLK-DKALFKKEKEI 121
Cdd:cd18696   74 AAEIEQAARIVKKYQdqrIGLADAANVVladnygTATILTlDRRHFSALRPI 125
PIN_MtVapC3-like_start cd09882
VapC-like PIN domain of Mycobacterium tuberculosis VapC3 toxin and related proteins; The ...
 2-106 8.85e-07

VapC-like PIN domain of Mycobacterium tuberculosis VapC3 toxin and related proteins; The VapC3-like nuclease subfamily includes the Virulence associated protein C (VapC)-like PIN (PilT N terminus) domain of various Mycobacterium tuberculosis VapC toxins including VapC3, VapC11, VapC15, and VapC21. It belongs to the VapC-like family of the PIN domain nuclease superfamily. VapC is a PIN-domain ribonuclease toxin from prokaryotic VapBC toxin-antitoxin (TA) systems. VapB is a transcription factor-like protein antitoxin acting as an inhibitor. Other members of the VapC-like nuclease family include FitB toxin of the FitAB TA system, eukaryotic ribonucleases such as Smg6, ribosome assembly factor NOB1, exosome subunit Rrp44 endoribonuclease and rRNA-processing protein Fcf1. The structural properties of the PIN (PilT N terminus) domain indicate its active center, consisting of three highly conserved catalytic residues which coordinate metal ions, in some members, additional metal coordinating residues can be found. Some members of the superfamily lack several of these key catalytic residues. The PIN active site is geometrically similar in the active center of structure-specific 5' nucleases, PIN-domain ribonucleases of eukaryotic rRNA editing proteins, and bacterial toxins of toxin-antitoxin (TA) operons.


Pssm-ID: 350230  Cd Length: 128  Bit Score: 44.89  E-value: 8.85e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502108611   2 IVDTGVLIEYINEEG-KYHEKVKKLIESNTSLFVTPITLSEVLyvsyrvyraAGSNDANDYAKefVEWLLSKLKVTEINH 80
Cdd:cd09882    1 LVDTSVWIDFFRGRDtPQVERLKELIEEGEDVALTGIILTEVL---------QGIRDEKEFQR--VKEYLLALPILPLTG 69

                         90       100       110
                 ....*....|....*....|....*....|..
gi 502108611  81 EIVIKAGEI------KKKYGIALPDCYVIATA 106
Cdd:cd09882   70 ETYIAAARLyrrlrrKGVTVRSTIDCLIAATA 101
PIN_VapC-like cd18686
uncharacterized subfamily of the VapC (virulence-associated protein C)-like family of the PIN ...
 2-106 4.20e-06

uncharacterized subfamily of the VapC (virulence-associated protein C)-like family of the PIN domain superfamily; VapC is the PIN-domain ribonuclease toxin from prokaryotic VapBC toxin-antitoxin (TA) systems. VapB is a transcription factor-like protein antitoxin acting as an inhibitor. Other members of the VapC-like nuclease family include FitB toxin of the FitAB TA system, eukaryotic ribonucleases such as Smg6, ribosome assembly factor NOB1, exosome subunit Rrp44 endoribonuclease and rRNA-processing protein Fcf1. The PIN domain belongs to a large nuclease superfamily. The structural properties of the PIN (PilT N terminus) domain indicate its active center, consisting of three highly conserved catalytic residues which coordinate metal ions, in some members, additional metal coordinating residues can be found. Some members of the superfamily lack several of these key catalytic residues. The PIN active site is geometrically similar in the active center of structure-specific 5' nucleases, PIN-domain ribonucleases of eukaryotic rRNA editing proteins, and bacterial toxins of toxin-antitoxin (TA) operons.


Pssm-ID: 350253  Cd Length: 119  Bit Score: 42.87  E-value: 4.20e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502108611   2 IVDTGVLIEYINEeGKYHEKVKKLIESNTSLFVTPITLSEVlyvSYRVYRAAGSNDANdyakEFVEwLLSKLKVTEINHE 81
Cdd:cd18686    1 VVDSSGWIEYFAD-GPLADEFAPAIEDPEELIVPTIVLYEV---YKKILRERGEEAAL----EAVA-LMQQGRVVPLDES 71

                         90       100
                 ....*....|....*....|....*
gi 502108611  82 IVIKAGEIKKKYGIALPDCYVIATA 106
Cdd:cd18686   72 LALAAADLSLEHKLPMADSIIYATA 96
PIN_VapC4-5_FitB-like cd09881
VapC-like PIN domain of Mycobacterium tuberculosis VapC4 and VapC5, and Neisseria gonorrhoeae ...
 2-106 1.43e-05

VapC-like PIN domain of Mycobacterium tuberculosis VapC4 and VapC5, and Neisseria gonorrhoeae FitB and related proteins; This family includes the Virulence associated protein C (VapC)-like PIN (PilT N terminus) domain of Mycobacterium tuberculosis VapC4 and VapC5 ribonuclease toxins of the VapBC toxin/antitoxin (TA) system, and Neisseria gonorrhoeae FitB toxin of the FitAB TA system. This family belongs to the VapC-like family of the PIN domain nuclease superfamily. VapC is the PIN-domain ribonuclease toxin from prokaryotic VapBC toxin-antitoxin (TA) systems. VapB is a transcription factor-like protein antitoxin acting as an inhibitor. Other members of the VapC-like nuclease family include eukaryotic ribonucleases such as Smg6, ribosome assembly factor NOB1, exosome subunit Rrp44 endoribonuclease and rRNA-processing protein Fcf1. The structural properties of the PIN (PilT N terminus) domain indicate its active center, consisting of three highly conserved catalytic residues which coordinate metal ions, in some members, additional metal coordinating residues can be found. Some members of the superfamily lack several of these key catalytic residues. The PIN active site is geometrically similar in the active center of structure-specific 5' nucleases, PIN-domain ribonucleases of eukaryotic rRNA editing proteins, and bacterial toxins of toxin-antitoxin (TA) operons.


Pssm-ID: 350229  Cd Length: 127  Bit Score: 41.70  E-value: 1.43e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502108611   2 IVDTGVLIEYINeeGKYHEKVKKLIESNTS-LFVTPITLSEVLYVSYRVYRAAGsndandyAKEFVEWLLSKLKVTEINH 80
Cdd:cd09881    1 LLDTNICIDLLR--GRPPSVLERLEELLPEdLAISSITLAELLYGAEKSQRPEK-------NLAALEAFLSRLEVLPFDE 71

                         90       100       110
                 ....*....|....*....|....*....|.
gi 502108611  81 EIVIKAGEIK---KKYG--IALPDCYVIATA 106
Cdd:cd09881   72 EAAEIYGEIRaelEKKGkpIGDNDLLIAATA 102
PIN_VapC-like cd18684
uncharacterized subfamily of the VapC (virulence-associated protein C)-like family of the PIN ...
 2-110 1.79e-04

uncharacterized subfamily of the VapC (virulence-associated protein C)-like family of the PIN domain superfamily; VapC is the PIN-domain ribonuclease toxin from prokaryotic VapBC toxin-antitoxin (TA) systems. VapB is a transcription factor-like protein antitoxin acting as an inhibitor. Other members of the VapC-like nuclease family include FitB toxin of the FitAB TA system, eukaryotic ribonucleases such as Smg6, ribosome assembly factor NOB1, exosome subunit Rrp44 endoribonuclease and rRNA-processing protein Fcf1. The PIN domain belongs to a large nuclease superfamily. The structural properties of the PIN (PilT N terminus) domain indicate its active center, consisting of three highly conserved catalytic residues which coordinate metal ions, in some members, additional metal coordinating residues can be found. Some members of the superfamily lack several of these key catalytic residues. The PIN active site is geometrically similar in the active center of structure-specific 5' nucleases, PIN-domain ribonucleases of eukaryotic rRNA editing proteins, and bacterial toxins of toxin-antitoxin (TA) operons.


Pssm-ID: 350251  Cd Length: 131  Bit Score: 38.75  E-value: 1.79e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502108611   2 IVDTGVLIEYINEEGKYHEKVKKLIESNTSLFVTPITLSEVLYVSyrvyraAGSNDANDYAKEFVEWLLSKLKVTEI--N 79
Cdd:cd18684    2 VVDTNVLIYDTVEDSEYHKEARELLDSLEKWVIPTIVVHELVWFL------RKLGLSPDDAKEKVEEYLEDPRFEVVceD 75

                         90       100       110
                 ....*....|....*....|....*....|....
gi 502108611  80 HEIVIKAGEIKKKYGIALP---DCYVIATADYLK 110
Cdd:cd18684   76 REDIKSALELLLEEGLSLSrynDYVILAVAKRLK 109
VapC COG4113
RNA interferase (RNase) VapC, contains PIN domain [Defense mechanisms];
1-121 2.55e-04

RNA interferase (RNase) VapC, contains PIN domain [Defense mechanisms];


Pssm-ID: 443289  Cd Length: 125  Bit Score: 38.35  E-value: 2.55e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502108611   1 MIVDTGVLIEYINEEgKYHEKVKKLIESNTSLFVTP-ITLSEVLYV-SYRVYRAAGSNDAndyAKEFVEwLLSKLKVTEI 78
Cdd:COG4113    1 IVVDASALVKWLLPE-EGSEEALRLLERAADELVAPdLALYEVANVlWKAVRRGRLTEEE---AEEALE-LLLELPIEVV 75

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|
gi 502108611  79 NH-EIVIKAGEIKKKYGIALPDCYVIATADYLK------DKALFKKEKEI 121
Cdd:COG4113   76 PVtELLERALELARRHGLTAYDAAYLALAERLGaplvtaDRRLARAARAL 125
PIN_MtVapC3-like cd18765
uncharacterized subgroup of the VapC3-like nuclease subfamily of the PIN domain superfamily; ...
 2-43 5.95e-04

uncharacterized subgroup of the VapC3-like nuclease subfamily of the PIN domain superfamily; The VapC3-like nuclease subfamily includes the Virulence associated protein C (VapC)-like PIN (PilT N terminus) domain of various Mycobacterium tuberculosis VapC toxins including VapC3, VapC11, VapC15, VapC21, VapC25, VapC28, VapC29, VapC30, VapC32, VapC33, VapC37, and VapC39. It belongs to the VapC-like family of the PIN domain nuclease superfamily. VapC is a PIN-domain ribonuclease toxin from prokaryotic VapBC toxin-antitoxin (TA) systems. VapB is a transcription factor-like protein antitoxin acting as an inhibitor. Other members of the VapC-like nuclease family include FitB toxin of the FitAB TA system, eukaryotic ribonucleases such as Smg6, ribosome assembly factor NOB1, exosome subunit Rrp44 endoribonuclease and rRNA-processing protein Fcf1. The structural properties of the PIN domain indicate its active center, consisting of three highly conserved catalytic residues which coordinate metal ions; in some members, additional metal coordinating residues can be found while some others lack several of these key catalytic residues. The PIN active site is geometrically similar in the active center of structure-specific 5' nucleases, PIN-domain ribonucleases of eukaryotic rRNA editing proteins, and bacterial toxins of toxin-antitoxin (TA) operons.


Pssm-ID: 350332  Cd Length: 131  Bit Score: 37.37  E-value: 5.95e-04
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|...
gi 502108611   2 IVDTGVLIEYINEEG-KYHEKVKKLIESNTSLFVTPITLSEVL 43
Cdd:cd18765    1 LVDTSVWIDLLRGTGtPAVRRLRRLLQSEEPVALAPVILQELL 43
PIN_VapC4-5_FitB-like cd18737
uncharacterized subgroup of the PIN_VapC4-5_FitB-like subfamily of the PIN domain superfamily; ...
 4-106 1.01e-03

uncharacterized subgroup of the PIN_VapC4-5_FitB-like subfamily of the PIN domain superfamily; The PIN_VapC4-5_FitB-like subfamily includes the Virulence associated protein C (VapC)-like PIN (PilT N terminus) domain of Mycobacterium tuberculosis VapC4 and VapC5 ribonuclease toxins of the VapBC toxin/antitoxin (TA) system, and Neisseria gonorrhoeae FitB toxin of the FitAB TA system. This subfamily belongs to the VapC-like family of the PIN domain nuclease superfamily. VapC is the PIN-domain ribonuclease toxin from prokaryotic VapBC toxin-antitoxin (TA) systems. VapB is a transcription factor-like protein antitoxin acting as an inhibitor. Other members of the VapC-like nuclease family include eukaryotic ribonucleases such as Smg6, ribosome assembly factor NOB1, exosome subunit Rrp44 endoribonuclease and rRNA-processing protein Fcf1. The structural properties of the PIN (PilT N terminus) domain indicate its active center, consisting of three highly conserved catalytic residues which coordinate metal ions, in some members, additional metal coordinating residues can be found. Some members of the superfamily lack several of these key catalytic residues. The PIN active site is geometrically similar in the active center of structure-specific 5' nucleases, PIN-domain ribonucleases of eukaryotic rRNA editing proteins, and bacterial toxins of toxin-antitoxin (TA) operons.


Pssm-ID: 350304  Cd Length: 115  Bit Score: 36.36  E-value: 1.01e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502108611   4 DTGVLIEYINeeGkyHEKVKKLIESNTSLFVTPITLSEVLyvsyrvyraAGSNDANDYAkefVEWLLSKLKVTEINHEIV 83
Cdd:cd18737    3 DTNILIDYLN--G--VPQARAELERYEQPAISVITWMEVL---------VGAPPEEEEA---TRAFLSSFEIIPLDQAIA 66

                         90       100
                 ....*....|....*....|...
gi 502108611  84 IKAGEIKKKYGIALPDCYVIATA 106
Cdd:cd18737   67 ERAVALRRQSRLKLPDAIILATA 89
PIN_VapC-like cd09854
VapC-like PIN domains of VapC and Smg6 ribonucleases, ribosome assembly factor NOB1, ...
 2-114 3.59e-03

VapC-like PIN domains of VapC and Smg6 ribonucleases, ribosome assembly factor NOB1, rRNA-processing protein Fcf1, Archaeoglobus fulgidus AF0591 protein, and homologs; PIN (PilT N terminus) domains of such ribonucleases as the toxins of prokaryotic toxin/antitoxin operons FitAB and VapBC, as well as, eukaryotic ribonucleases such as Smg6, ribosome assembly factor NOB1, exosome subunit Rrp44 endoribonuclease and rRNA-processing protein Fcf1, are included in VapC-like this family. Also included are the PIN domains of the Pyrobaculum aerophilum Pea0151 and Archaeoglobus fulgidus AF0591 proteins and other similar archaeal homologs. The PIN domain belongs to a large nuclease superfamily. The structural properties of the PIN domain indicate its active center, consisting of three highly conserved catalytic residues which coordinate metal ions; in some members, additional metal coordinating residues can be found while some others lack several of these key catalytic residues. The PIN active site is geometrically similar in the active center of structure-specific 5' nucleases, PIN-domain ribonucleases of eukaryotic rRNA editing proteins, and bacterial toxins of toxin-antitoxin (TA) operons.


Pssm-ID: 350205  Cd Length: 129  Bit Score: 35.33  E-value: 3.59e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502108611   2 IVDTGVLIEYINEEGKYHEKVK--KLIESNTSLFVTPITLSEVLYVSYRVYRAAGSNDANDYAkEFVEWLLSKLKVtein 79
Cdd:cd09854    1 VLDTNVLIALLSSEPESEAAKEllALLLGDSELVIPPLVLAELLRLLARERGARRALEILELL-RALEVVEEEPAL---- 75

                         90       100       110
                 ....*....|....*....|....*....|....*
gi 502108611  80 HEIVIKAGEIKKKYGIALPDCYVIATADYLKDKAL 114
Cdd:cd09854   76 AEIALEVLALGLERGLDFGDALILALAKELGGAVL 110
PIN_VapC4-5_FitB-like cd18754
uncharacterized subgroup of the PIN_VapC4-5_FitB-like subfamily of the PIN domain superfamily; ...
 2-106 6.65e-03

uncharacterized subgroup of the PIN_VapC4-5_FitB-like subfamily of the PIN domain superfamily; The PIN_VapC4-5_FitB-like subfamily includes the Virulence associated protein C (VapC)-like PIN (PilT N terminus) domain of Mycobacterium tuberculosis VapC4 and VapC5 ribonuclease toxins of the VapBC toxin/antitoxin (TA) system, and Neisseria gonorrhoeae FitB toxin of the FitAB TA system. This subfamily belongs to the VapC-like family of the PIN domain nuclease superfamily. VapC is the PIN-domain ribonuclease toxin from prokaryotic VapBC toxin-antitoxin (TA) systems. VapB is a transcription factor-like protein antitoxin acting as an inhibitor. Other members of the VapC-like nuclease family include eukaryotic ribonucleases such as Smg6, ribosome assembly factor NOB1, exosome subunit Rrp44 endoribonuclease and rRNA-processing protein Fcf1. The structural properties of the PIN (PilT N terminus) domain indicate its active center, consisting of three highly conserved catalytic residues which coordinate metal ions, in some members, additional metal coordinating residues can be found. Some members of the superfamily lack several of these key catalytic residues. The PIN active site is geometrically similar in the active center of structure-specific 5' nucleases, PIN-domain ribonucleases of eukaryotic rRNA editing proteins, and bacterial toxins of toxin-antitoxin (TA) operons.


Pssm-ID: 350321  Cd Length: 128  Bit Score: 34.50  E-value: 6.65e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502108611   2 IVDTGVLIEYINEEGKYHEKVKKLIESNTSLFVTPITLSEvLYVSyrVYRAAgsndANDYAKEFVEWLLSKLKVTEINHE 81
Cdd:cd18754    1 ILDTSFLIDLMRGDEAAIEKARELESESVPQRVSSPTVFE-LYVG--VGLSA----APEEERERIESVLESKPILPLDGE 73

                         90       100       110
                 ....*....|....*....|....*....|
gi 502108611  82 IVIKAGEI---KKKYG--IALPDCYVIATA 106
Cdd:cd18754   74 SARKAGRIdgqLRREGepIDPGDAMIAATA 103
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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