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Conserved domains on  [gi|502298505|ref|WP_012755326|]
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MULTISPECIES: phosphopantetheine-binding protein [Rhizobium]

Protein Classification

acyl carrier protein( domain architecture ID 516)

acyl carrier protein may function as a carrier of the growing fatty acid chain in fatty acid biosynthesis or as the carrier of activated (amino) acid groups in polyketide synthases and non-ribosomal peptide synthases

Gene Ontology:  GO:0006633
PubMed:  30543875

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PP-binding super family cl09936
Phosphopantetheine attachment site; A 4'-phosphopantetheine prosthetic group is attached ...
 6-91 4.29e-07

Phosphopantetheine attachment site; A 4'-phosphopantetheine prosthetic group is attached through a serine. This prosthetic group acts as a a 'swinging arm' for the attachment of activated fatty acid and amino-acid groups. This domain forms a four helix bundle. This family includes members not included in Prosite. The inclusion of these members is supported by sequence analysis and functional evidence. The related domain of Swiss:P19828 has the attachment serine replaced by an alanine.


The actual alignment was detected with superfamily member PRK05828:

Pssm-ID: 447865  Cd Length: 84  Bit Score: 43.70  E-value: 4.29e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502298505  6 TVEIIAAIKNLAQSENggrIPVAIGEITADSELTSLGIDSLALADVLWDLEQAYGIRIEmntADAWSNLKNIGDVVEAVR 85
Cdd:PRK05828  3 EMEILLKIKEIAKKKN---FAVTLDESNINKPYRELKIDSLDMFSIIVSLESEFNIEFS---DEKLMKLKNLADLILEVK 76


                ....*.
gi 502298505 86 GLIAKE 91
Cdd:PRK05828 77 ELKKQK 82
 
Name Accession Description Interval E-value
PRK05828 PRK05828
acyl carrier protein; Validated
 6-91 4.29e-07

acyl carrier protein; Validated


Pssm-ID: 180278  Cd Length: 84  Bit Score: 43.70  E-value: 4.29e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502298505  6 TVEIIAAIKNLAQSENggrIPVAIGEITADSELTSLGIDSLALADVLWDLEQAYGIRIEmntADAWSNLKNIGDVVEAVR 85
Cdd:PRK05828  3 EMEILLKIKEIAKKKN---FAVTLDESNINKPYRELKIDSLDMFSIIVSLESEFNIEFS---DEKLMKLKNLADLILEVK 76


                ....*.
gi 502298505 86 GLIAKE 91
Cdd:PRK05828 77 ELKKQK 82
PP-binding pfam00550
Phosphopantetheine attachment site; A 4'-phosphopantetheine prosthetic group is attached ...
 27-76 3.28e-06

Phosphopantetheine attachment site; A 4'-phosphopantetheine prosthetic group is attached through a serine. This prosthetic group acts as a a 'swinging arm' for the attachment of activated fatty acid and amino-acid groups. This domain forms a four helix bundle. This family includes members not included in Prosite. The inclusion of these members is supported by sequence analysis and functional evidence. The related domain of Swiss:P19828 has the attachment serine replaced by an alanine.


Pssm-ID: 425746 [Multi-domain]  Cd Length: 62  Bit Score: 40.62  E-value: 3.28e-06
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|
gi 502298505  27 VAIGEITADSELTSLGIDSLALADVLWDLEQAYGIRIEMNTADAWSNLKN 76
Cdd:pfam00550 13 VPAEEIDPDTDLFDLGLDSLLAVELIARLEEEFGVEIPPSDLFEHPTLAE 62
AcpP COG0236
Acyl carrier protein [Lipid transport and metabolism]; Acyl carrier protein is part of the ...
 8-89 1.35e-05

Acyl carrier protein [Lipid transport and metabolism]; Acyl carrier protein is part of the Pathway/BioSystem: Fatty acid biosynthesis


Pssm-ID: 440006 [Multi-domain]  Cd Length: 80  Bit Score: 39.45  E-value: 1.35e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502298505  8 EIIAAIKNLAQSENGgripVAIGEITADSELTS-LGIDSLALADVLWDLEQAYGIRIEMNTADawsNLKNIGDVVEAVRG 86
Cdd:COG0236   5 ELEERLAEIIAEVLG----VDPEEITPDDSFFEdLGLDSLDAVELIAALEEEFGIELPDTELF---EYPTVADLADYLEE 77


                ...
gi 502298505 87 LIA 89
Cdd:COG0236  78 KLA 80
 
Name Accession Description Interval E-value
PRK05828 PRK05828
acyl carrier protein; Validated
 6-91 4.29e-07

acyl carrier protein; Validated


Pssm-ID: 180278  Cd Length: 84  Bit Score: 43.70  E-value: 4.29e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502298505  6 TVEIIAAIKNLAQSENggrIPVAIGEITADSELTSLGIDSLALADVLWDLEQAYGIRIEmntADAWSNLKNIGDVVEAVR 85
Cdd:PRK05828  3 EMEILLKIKEIAKKKN---FAVTLDESNINKPYRELKIDSLDMFSIIVSLESEFNIEFS---DEKLMKLKNLADLILEVK 76


                ....*.
gi 502298505 86 GLIAKE 91
Cdd:PRK05828 77 ELKKQK 82
PP-binding pfam00550
Phosphopantetheine attachment site; A 4'-phosphopantetheine prosthetic group is attached ...
 27-76 3.28e-06

Phosphopantetheine attachment site; A 4'-phosphopantetheine prosthetic group is attached through a serine. This prosthetic group acts as a a 'swinging arm' for the attachment of activated fatty acid and amino-acid groups. This domain forms a four helix bundle. This family includes members not included in Prosite. The inclusion of these members is supported by sequence analysis and functional evidence. The related domain of Swiss:P19828 has the attachment serine replaced by an alanine.


Pssm-ID: 425746 [Multi-domain]  Cd Length: 62  Bit Score: 40.62  E-value: 3.28e-06
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|
gi 502298505  27 VAIGEITADSELTSLGIDSLALADVLWDLEQAYGIRIEMNTADAWSNLKN 76
Cdd:pfam00550 13 VPAEEIDPDTDLFDLGLDSLLAVELIARLEEEFGVEIPPSDLFEHPTLAE 62
AcpP COG0236
Acyl carrier protein [Lipid transport and metabolism]; Acyl carrier protein is part of the ...
 8-89 1.35e-05

Acyl carrier protein [Lipid transport and metabolism]; Acyl carrier protein is part of the Pathway/BioSystem: Fatty acid biosynthesis


Pssm-ID: 440006 [Multi-domain]  Cd Length: 80  Bit Score: 39.45  E-value: 1.35e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502298505  8 EIIAAIKNLAQSENGgripVAIGEITADSELTS-LGIDSLALADVLWDLEQAYGIRIEMNTADawsNLKNIGDVVEAVRG 86
Cdd:COG0236   5 ELEERLAEIIAEVLG----VDPEEITPDDSFFEdLGLDSLDAVELIAALEEEFGIELPDTELF---EYPTVADLADYLEE 77


                ...
gi 502298505 87 LIA 89
Cdd:COG0236  78 KLA 80
PTZ00171 PTZ00171
acyl carrier protein; Provisional
 31-82 4.48e-03

acyl carrier protein; Provisional


Pssm-ID: 240304  Cd Length: 148  Bit Score: 33.90  E-value: 4.48e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|...
gi 502298505  31 EITADSELT-SLGIDSLALADVLWDLEQAYGIRIEMNTADawsNLKNIGDVVE 82
Cdd:PTZ00171  89 KITPESNFVkDLGADSLDVVELLIAIEQEFNLTIPDHDAE---KIKTVQDAID 138
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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