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Conserved domains on  [gi|502306585|ref|WP_012758305|]
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class I SAM-dependent methyltransferase [Rhizobium leguminosarum]

Protein Classification

class I SAM-dependent methyltransferase( domain architecture ID 10789277)

class I SAM-dependent methyltransferase is an enzyme that uses S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyl transfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)

CATH:  2.20.25.110
EC:  2.1.1.-
Gene Ontology:  GO:0008168|GO:1904047
PubMed:  12826405
SCOP:  3000118

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
UbiE COG2226
Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG [Coenzyme transport and metabolism]; ...
 30-176 4.88e-23

Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG [Coenzyme transport and metabolism]; Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG is part of the Pathway/BioSystem: Biotin biosynthesis


:

Pssm-ID: 441828 [Multi-domain]  Cd Length: 143  Bit Score: 90.44  E-value: 4.88e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502306585  30 YDLTRKYYLLgRDSTIRNLDVAEGGSLLEVGCGTGRNMAFAHRHfpTAKLFGLDISQEMLISARKTFATKATIPEFRVAD 109
Cdd:COG2226    1 FDRVAARYDG-REALLAALGLRPGARVLDLGCGTGRLALALAER--GARVTGVDISPEMLELARERAAEAGLNVEFVVGD 77

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 502306585 110 ATAFtprEFGVSGFDRILISYALSMIPDWERAVDASIAALNPGGQLHIVDFGQQEglPGWFRRMLQS 176
Cdd:COG2226   78 AEDL---PFPDGSFDLVISSFVLHHLPDPERALAEIARVLKPGGRLVVVDFSPPD--LAELEELLAE 139
 
Name Accession Description Interval E-value
UbiE COG2226
Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG [Coenzyme transport and metabolism]; ...
 30-176 4.88e-23

Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG [Coenzyme transport and metabolism]; Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG is part of the Pathway/BioSystem: Biotin biosynthesis


Pssm-ID: 441828 [Multi-domain]  Cd Length: 143  Bit Score: 90.44  E-value: 4.88e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502306585  30 YDLTRKYYLLgRDSTIRNLDVAEGGSLLEVGCGTGRNMAFAHRHfpTAKLFGLDISQEMLISARKTFATKATIPEFRVAD 109
Cdd:COG2226    1 FDRVAARYDG-REALLAALGLRPGARVLDLGCGTGRLALALAER--GARVTGVDISPEMLELARERAAEAGLNVEFVVGD 77

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 502306585 110 ATAFtprEFGVSGFDRILISYALSMIPDWERAVDASIAALNPGGQLHIVDFGQQEglPGWFRRMLQS 176
Cdd:COG2226   78 AEDL---PFPDGSFDLVISSFVLHHLPDPERALAEIARVLKPGGRLVVVDFSPPD--LAELEELLAE 139
Methyltransf_25 pfam13649
Methyltransferase domain; This family appears to be a methyltransferase domain.
 57-153 7.26e-18

Methyltransferase domain; This family appears to be a methyltransferase domain.


Pssm-ID: 463945 [Multi-domain]  Cd Length: 96  Bit Score: 75.29  E-value: 7.26e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502306585   57 LEVGCGTGRNMAFAHRHFPtAKLFGLDISQEMLISARKTFATKATIPEFRVADATAFtprEFGVSGFDRILISYALSMI- 135
Cdd:pfam13649   2 LDLGCGTGRLTLALARRGG-ARVTGVDLSPEMLERARERAAEAGLNVEFVQGDAEDL---PFPDGSFDLVVSSGVLHHLp 77

                          90
                  ....*....|....*....
gi 502306585  136 -PDWERAVDASIAALNPGG 153
Cdd:pfam13649  78 dPDLEAALREIARVLKPGG 96
PRK08317 PRK08317
hypothetical protein; Provisional
 41-181 3.13e-14

hypothetical protein; Provisional


Pssm-ID: 181382 [Multi-domain]  Cd Length: 241  Bit Score: 69.20  E-value: 3.13e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502306585  41 RDSTIRNLDVAEGGSLLEVGCGTGRNM-AFAHRHFPTAKLFGLDISQEMLISARKTFATKATIPEFRVADATAFtprEFG 119
Cdd:PRK08317   8 RARTFELLAVQPGDRVLDVGCGPGNDArELARRVGPEGRVVGIDRSEAMLALAKERAAGLGPNVEFVRGDADGL---PFP 84

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502306585 120 VSGFDRILISYALSMIPDWERAVDASIAALNPGGQLHIVDF--------GQQEGLpgwFRRMLQSWLAKF 181
Cdd:PRK08317  85 DGSFDAVRSDRVLQHLEDPARALAEIARVLRPGGRVVVLDTdwdtlvwhSGDRAL---MRKILNFWSDHF 151
AdoMet_MTases cd02440
S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; ...
 56-160 2.30e-08

S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). There are at least five structurally distinct families of AdoMet-MTases, class I being the largest and most diverse. Within this class enzymes can be classified by different substrate specificities (small molecules, lipids, nucleic acids, etc.) and different target atoms for methylation (nitrogen, oxygen, carbon, sulfur, etc.).


Pssm-ID: 100107 [Multi-domain]  Cd Length: 107  Bit Score: 50.51  E-value: 2.30e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502306585  56 LLEVGCGTGRNmAFAHRHFPTAKLFGLDISQEMLISARKTFATKATIP-EFRVADATAFTPREFGvsGFDRILISYALSM 134
Cdd:cd02440    2 VLDLGCGTGAL-ALALASGPGARVTGVDISPVALELARKAAAALLADNvEVLKGDAEELPPEADE--SFDVIISDPPLHH 78

                         90       100
                 ....*....|....*....|....*..
gi 502306585 135 IP-DWERAVDASIAALNPGGQLHIVDF 160
Cdd:cd02440   79 LVeDLARFLEEARRLLKPGGVLVLTLV 105
BioC TIGR02072
malonyl-acyl carrier protein O-methyltransferase BioC; This enzyme, which is found in biotin ...
 13-209 4.19e-07

malonyl-acyl carrier protein O-methyltransferase BioC; This enzyme, which is found in biotin biosynthetic gene clusters in proteobacteria, firmicutes, green-sulfur bacteria, fusobacterium and bacteroides, carries out an enzymatic step prior to the formation of pimeloyl-CoA, namely O-methylation of the malonyl group preferentially while on acyl carrier protein. The enzyme is recognizable as a methyltransferase by homology. [Biosynthesis of cofactors, prosthetic groups, and carriers, Biotin]


Pssm-ID: 273953 [Multi-domain]  Cd Length: 240  Bit Score: 49.21  E-value: 4.19e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502306585   13 DQHASLmdgmyryQRHIydltrKYYLLGRdstIRNLDVAEGGSLLEVGCGTGrnMAFAH--RHFPTAKLFGLDISQEMLI 90
Cdd:TIGR02072  10 DRHAKI-------QREM-----AKRLLAL---LKEKGIFIPASVLDIGCGTG--YLTRAllKRFPQAEFIALDISAGMLA 72

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502306585   91 SARKTFATKATipeFRVADATAFTPREfgvSGFDRILISYALSMIPDWERAVDASIAALNPGGQLHIVDFGQQEglpgwF 170
Cdd:TIGR02072  73 QAKTKLSENVQ---FICGDAEKLPLED---SSFDLIVSNLALQWCDDLSQALSELARVLKPGGLLAFSTFGPGT-----L 141

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*..
gi 502306585  171 RRMLQSWlaKFHVTPRPDLREVLEA--------QAHENNATLVFDAV 209
Cdd:TIGR02072 142 HELRQSF--GQHGLRYLSLDELKALlknsfellTLEEELITLSFDDP 186
 
Name Accession Description Interval E-value
UbiE COG2226
Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG [Coenzyme transport and metabolism]; ...
 30-176 4.88e-23

Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG [Coenzyme transport and metabolism]; Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG is part of the Pathway/BioSystem: Biotin biosynthesis


Pssm-ID: 441828 [Multi-domain]  Cd Length: 143  Bit Score: 90.44  E-value: 4.88e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502306585  30 YDLTRKYYLLgRDSTIRNLDVAEGGSLLEVGCGTGRNMAFAHRHfpTAKLFGLDISQEMLISARKTFATKATIPEFRVAD 109
Cdd:COG2226    1 FDRVAARYDG-REALLAALGLRPGARVLDLGCGTGRLALALAER--GARVTGVDISPEMLELARERAAEAGLNVEFVVGD 77

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 502306585 110 ATAFtprEFGVSGFDRILISYALSMIPDWERAVDASIAALNPGGQLHIVDFGQQEglPGWFRRMLQS 176
Cdd:COG2226   78 AEDL---PFPDGSFDLVISSFVLHHLPDPERALAEIARVLKPGGRLVVVDFSPPD--LAELEELLAE 139
Tam COG4106
Trans-aconitate methyltransferase [Energy production and conversion];
52-159 2.15e-18

Trans-aconitate methyltransferase [Energy production and conversion];


Pssm-ID: 443282 [Multi-domain]  Cd Length: 100  Bit Score: 76.79  E-value: 2.15e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502306585  52 EGGSLLEVGCGTGRNMAFAHRHFPTAKLFGLDISQEMLISARKTFatkatiP--EFRVADATAFTPREfgvsGFDRILIS 129
Cdd:COG4106    1 PPRRVLDLGCGTGRLTALLAERFPGARVTGVDLSPEMLARARARL------PnvRFVVADLRDLDPPE----PFDLVVSN 70

                         90       100       110
                 ....*....|....*....|....*....|
gi 502306585 130 YALSMIPDWERAVDASIAALNPGGQLHIVD 159
Cdd:COG4106   71 AALHWLPDHAALLARLAAALAPGGVLAVQV 100
Methyltransf_25 pfam13649
Methyltransferase domain; This family appears to be a methyltransferase domain.
 57-153 7.26e-18

Methyltransferase domain; This family appears to be a methyltransferase domain.


Pssm-ID: 463945 [Multi-domain]  Cd Length: 96  Bit Score: 75.29  E-value: 7.26e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502306585   57 LEVGCGTGRNMAFAHRHFPtAKLFGLDISQEMLISARKTFATKATIPEFRVADATAFtprEFGVSGFDRILISYALSMI- 135
Cdd:pfam13649   2 LDLGCGTGRLTLALARRGG-ARVTGVDLSPEMLERARERAAEAGLNVEFVQGDAEDL---PFPDGSFDLVVSSGVLHHLp 77

                          90
                  ....*....|....*....
gi 502306585  136 -PDWERAVDASIAALNPGG 153
Cdd:pfam13649  78 dPDLEAALREIARVLKPGG 96
UbiG COG2227
2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase [Coenzyme transport and ...
 50-159 1.18e-15

2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase [Coenzyme transport and metabolism]; 2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase is part of the Pathway/BioSystem: Ubiquinone biosynthesis


Pssm-ID: 441829 [Multi-domain]  Cd Length: 126  Bit Score: 70.43  E-value: 1.18e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502306585  50 VAEGGSLLEVGCGTGRNMAFAHRHFptAKLFGLDISQEMLISARKtFATKATIpEFRVADATAFtprEFGVSGFDRILIS 129
Cdd:COG2227   22 LPAGGRVLDVGCGTGRLALALARRG--ADVTGVDISPEALEIARE-RAAELNV-DFVQGDLEDL---PLEDGSFDLVICS 94

                         90       100       110
                 ....*....|....*....|....*....|
gi 502306585 130 YALSMIPDWERAVDASIAALNPGGQLHIVD 159
Cdd:COG2227   95 EVLEHLPDPAALLRELARLLKPGGLLLLST 124
SmtA COG0500
SAM-dependent methyltransferase [Secondary metabolites biosynthesis, transport and catabolism, ...
 30-206 5.64e-15

SAM-dependent methyltransferase [Secondary metabolites biosynthesis, transport and catabolism, General function prediction only];


Pssm-ID: 440266 [Multi-domain]  Cd Length: 199  Bit Score: 70.72  E-value: 5.64e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502306585  30 YDLTRKYYLLGRDSTIRNLDvaEGGSLLEVGCGTGRNM-AFAHRHFptAKLFGLDISQEMLISARKTfATKATIP--EFR 106
Cdd:COG0500    6 YSDELLPGLAALLALLERLP--KGGRVLDLGCGTGRNLlALAARFG--GRVIGIDLSPEAIALARAR-AAKAGLGnvEFL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502306585 107 VADATAFTPREFGvsGFDRILISYALSMIP--DWERAVDASIAALNPGGQLHIVDFGQQEGLPGwFRRMLQSWLAKFHVT 184
Cdd:COG0500   81 VADLAELDPLPAE--SFDLVVAFGVLHHLPpeEREALLRELARALKPGGVLLLSASDAAAALSL-ARLLLLATASLLELL 157

                        170       180
                 ....*....|....*....|...
gi 502306585 185 PR-PDLREVLEAQAHENNATLVF 206
Cdd:COG0500  158 LLlRLLALELYLRALLAAAATED 180
PRK08317 PRK08317
hypothetical protein; Provisional
 41-181 3.13e-14

hypothetical protein; Provisional


Pssm-ID: 181382 [Multi-domain]  Cd Length: 241  Bit Score: 69.20  E-value: 3.13e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502306585  41 RDSTIRNLDVAEGGSLLEVGCGTGRNM-AFAHRHFPTAKLFGLDISQEMLISARKTFATKATIPEFRVADATAFtprEFG 119
Cdd:PRK08317   8 RARTFELLAVQPGDRVLDVGCGPGNDArELARRVGPEGRVVGIDRSEAMLALAKERAAGLGPNVEFVRGDADGL---PFP 84

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502306585 120 VSGFDRILISYALSMIPDWERAVDASIAALNPGGQLHIVDF--------GQQEGLpgwFRRMLQSWLAKF 181
Cdd:PRK08317  85 DGSFDAVRSDRVLQHLEDPARALAEIARVLRPGGRVVVLDTdwdtlvwhSGDRAL---MRKILNFWSDHF 151
ubiE PRK00216
bifunctional demethylmenaquinone methyltransferase/2-methoxy-6-polyprenyl-1,4-benzoquinol ...
 41-186 5.45e-14

bifunctional demethylmenaquinone methyltransferase/2-methoxy-6-polyprenyl-1,4-benzoquinol methylase UbiE;


Pssm-ID: 234689 [Multi-domain]  Cd Length: 239  Bit Score: 68.64  E-value: 5.45e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502306585  41 RDSTIRNLDVAEGGSLLEVGCGTGRNM-AFAHRHFPTAKLFGLDISQEMLISARKTFATKATIP--EFRVADATAfTPre 117
Cdd:PRK00216  40 RRKTIKWLGVRPGDKVLDLACGTGDLAiALAKAVGKTGEVVGLDFSEGMLAVGREKLRDLGLSGnvEFVQGDAEA-LP-- 116

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502306585 118 FGVSGFDRILISYALSMIPDWERAVdASIA-ALNPGGQLHIVDFGQQEGlpGWFRRMLQSWLakFHVTPR 186
Cdd:PRK00216 117 FPDNSFDAVTIAFGLRNVPDIDKAL-REMYrVLKPGGRLVILEFSKPTN--PPLKKAYDFYL--FKVLPL 181
Methyltransf_12 pfam08242
Methyltransferase domain; Members of this family are SAM dependent methyltransferases.
 57-155 9.54e-14

Methyltransferase domain; Members of this family are SAM dependent methyltransferases.


Pssm-ID: 400515 [Multi-domain]  Cd Length: 98  Bit Score: 64.70  E-value: 9.54e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502306585   57 LEVGCGTGRNMAFAHRHFPTAKLFGLDISQEMLISARKTFA----TKATIPEFRVADATAFTPRefgvsGFDRILISYAL 132
Cdd:pfam08242   1 LEIGCGTGTLLRALLEALPGLEYTGLDISPAALEAARERLAalglLNAVRVELFQLDLGELDPG-----SFDVVVASNVL 75

                          90       100
                  ....*....|....*....|...
gi 502306585  133 SMIPDWERAVDASIAALNPGGQL 155
Cdd:pfam08242  76 HHLADPRAVLRNIRRLLKPGGVL 98
Cfa COG2230
Cyclopropane fatty-acyl-phospholipid synthase and related methyltransferases [Lipid transport ...
 42-159 1.06e-13

Cyclopropane fatty-acyl-phospholipid synthase and related methyltransferases [Lipid transport and metabolism];


Pssm-ID: 441831 [Multi-domain]  Cd Length: 158  Bit Score: 66.11  E-value: 1.06e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502306585  42 DSTIRNLDVAEGGSLLEVGCGTGRNMAFAHRHFpTAKLFGLDISQEMLISARKTFATK--ATIPEFRVADATAFTPREFg 119
Cdd:COG2230   41 DLILRKLGLKPGMRVLDIGCGWGGLALYLARRY-GVRVTGVTLSPEQLEYARERAAEAglADRVEVRLADYRDLPADGQ- 118

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|..
gi 502306585 120 vsgFDRILISYALSMIPD--WERAVDASIAALNPGGQLHIVD 159
Cdd:COG2230  119 ---FDAIVSIGMFEHVGPenYPAYFAKVARLLKPGGRLLLHT 157
Methyltransf_11 pfam08241
Methyltransferase domain; Members of this family are SAM dependent methyltransferases.
 57-157 3.68e-12

Methyltransferase domain; Members of this family are SAM dependent methyltransferases.


Pssm-ID: 462406 [Multi-domain]  Cd Length: 94  Bit Score: 60.37  E-value: 3.68e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502306585   57 LEVGCGTGRNMAFAHRHFPTakLFGLDISQEMLISARKtfATKATIPEFRVADATAfTPreFGVSGFDRILISYALSMIP 136
Cdd:pfam08241   1 LDVGCGTGLLTELLARLGAR--VTGVDISPEMLELARE--KAPREGLTFVVGDAED-LP--FPDNSFDLVLSSEVLHHVE 73

                          90       100
                  ....*....|....*....|.
gi 502306585  137 DWERAVDASIAALNPGGQLHI 157
Cdd:pfam08241  74 DPERALREIARVLKPGGILII 94
Ubie_methyltran pfam01209
ubiE/COQ5 methyltransferase family;
39-186 1.12e-11

ubiE/COQ5 methyltransferase family;


Pssm-ID: 395966 [Multi-domain]  Cd Length: 228  Bit Score: 62.07  E-value: 1.12e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502306585   39 LGRDSTIRNLDVAEGGSLLEVGCGTGR-NMAFAHRHFPTAKLFGLDISQEMLISARKTFATKATIP-EFRVADATAFtpr 116
Cdd:pfam01209  29 LWKDFTMKCMGVKRGNKFLDVAGGTGDwTFGLSDSAGSSGKVVGLDINENMLKEGEKKAKEEGKYNiEFLQGNAEEL--- 105

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502306585  117 EFGVSGFDRILISYALSMIPDWERAVDASIAALNPGGQLHIVDFGQQEgLPGwFRRMLQSWLakFHVTPR 186
Cdd:pfam01209 106 PFEDDSFDIVTISFGLRNFPDYLKVLKEAFRVLKPGGRVVCLEFSKPE-NPL-LSQAYELYF--KYVMPF 171
COG4976 COG4976
Predicted methyltransferase, contains TPR repeat [General function prediction only];
13-153 1.55e-11

Predicted methyltransferase, contains TPR repeat [General function prediction only];


Pssm-ID: 444001 [Multi-domain]  Cd Length: 181  Bit Score: 60.78  E-value: 1.55e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502306585  13 DQHAslmdgmYRYQRHIYDlTRKYYLLGR--DSTIRNLDVAEGGSLLEVGCGTGRnMAFAHRHFpTAKLFGLDISQEMLI 90
Cdd:COG4976   12 DQYA------DSYDAALVE-DLGYEAPALlaEELLARLPPGPFGRVLDLGCGTGL-LGEALRPR-GYRLTGVDLSEEMLA 82

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 502306585  91 SARKtfatKATIPEFRVADATAFTPREfgvSGFDRILISYALSMIPDWERAVDASIAALNPGG 153
Cdd:COG4976   83 KARE----KGVYDRLLVADLADLAEPD---GRFDLIVAADVLTYLGDLAAVFAGVARALKPGG 138
Methyltransf_31 pfam13847
Methyltransferase domain; This family appears to have methyltransferase activity.
 52-179 2.63e-09

Methyltransferase domain; This family appears to have methyltransferase activity.


Pssm-ID: 463998 [Multi-domain]  Cd Length: 150  Bit Score: 53.96  E-value: 2.63e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502306585   52 EGGSLLEVGCGTGR-NMAFAHRHFPTAKLFGLDISQEMLISARKTFATKATIP-EFRVADATAFtPREFGVSGFDRILIS 129
Cdd:pfam13847   3 KGMRVLDLGCGTGHlSFELAEELGPNAEVVGIDISEEAIEKARENAQKLGFDNvEFEQGDIEEL-PELLEDDKFDVVISN 81

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|
gi 502306585  130 YALSMIPDWERAVDASIAALNPGGQLHIVDFGQQEGLPGWFRRMLQSWLA 179
Cdd:pfam13847  82 CVLNHIPDPDKVLQEILRVLKPGGRLIISDPDSLAELPAHVKEDSTYYAG 131
Methyltransf_23 pfam13489
Methyltransferase domain; This family appears to be a methyltransferase domain.
 52-195 6.02e-09

Methyltransferase domain; This family appears to be a methyltransferase domain.


Pssm-ID: 404385 [Multi-domain]  Cd Length: 162  Bit Score: 53.20  E-value: 6.02e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502306585   52 EGGSLLEVGCGTGRNMAFAHRHFPTAklFGLDISQEMLISARKTFATKatipEFRVADATAFTPRefgvsgFDRILISYA 131
Cdd:pfam13489  22 SPGRVLDFGCGTGIFLRLLRAQGFSV--TGVDPSPIAIERALLNVRFD----QFDEQEAAVPAGK------FDVIVAREV 89

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 502306585  132 LSMIPDWERAVDASIAALNPGGQLHIVDFGQQEGLPGWFRRMlQSWL---AKFHVTPRPDLREVLEA 195
Cdd:pfam13489  90 LEHVPDPPALLRQIAALLKPGGLLLLSTPLASDEADRLLLEW-PYLRprnGHISLFSARSLKRLLEE 155
AdoMet_MTases cd02440
S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; ...
 56-160 2.30e-08

S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). There are at least five structurally distinct families of AdoMet-MTases, class I being the largest and most diverse. Within this class enzymes can be classified by different substrate specificities (small molecules, lipids, nucleic acids, etc.) and different target atoms for methylation (nitrogen, oxygen, carbon, sulfur, etc.).


Pssm-ID: 100107 [Multi-domain]  Cd Length: 107  Bit Score: 50.51  E-value: 2.30e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502306585  56 LLEVGCGTGRNmAFAHRHFPTAKLFGLDISQEMLISARKTFATKATIP-EFRVADATAFTPREFGvsGFDRILISYALSM 134
Cdd:cd02440    2 VLDLGCGTGAL-ALALASGPGARVTGVDISPVALELARKAAAALLADNvEVLKGDAEELPPEADE--SFDVIISDPPLHH 78

                         90       100
                 ....*....|....*....|....*..
gi 502306585 135 IP-DWERAVDASIAALNPGGQLHIVDF 160
Cdd:cd02440   79 LVeDLARFLEEARRLLKPGGVLVLTLV 105
RsmC COG2813
16S rRNA G1207 methylase RsmC [Translation, ribosomal structure and biogenesis]; 16S rRNA ...
 45-158 6.21e-08

16S rRNA G1207 methylase RsmC [Translation, ribosomal structure and biogenesis]; 16S rRNA G1207 methylase RsmC is part of the Pathway/BioSystem: 16S rRNA modification


Pssm-ID: 442062 [Multi-domain]  Cd Length: 191  Bit Score: 50.96  E-value: 6.21e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502306585  45 IRNLDVAEGGSLLEVGCGTGRNMAFAHRHFPTAKLFGLDISQEMLISARKTFAT-KATIPEFRVADATAFTPREfgvsGF 123
Cdd:COG2813   42 LEHLPEPLGGRVLDLGCGYGVIGLALAKRNPEARVTLVDVNARAVELARANAAAnGLENVEVLWSDGLSGVPDG----SF 117

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*
gi 502306585 124 DRIL----------ISYALsmipdWERAVDASIAALNPGGQLHIV 158
Cdd:COG2813  118 DLILsnppfhagraVDKEV-----AHALIADAARHLRPGGELWLV 157
BioC TIGR02072
malonyl-acyl carrier protein O-methyltransferase BioC; This enzyme, which is found in biotin ...
 13-209 4.19e-07

malonyl-acyl carrier protein O-methyltransferase BioC; This enzyme, which is found in biotin biosynthetic gene clusters in proteobacteria, firmicutes, green-sulfur bacteria, fusobacterium and bacteroides, carries out an enzymatic step prior to the formation of pimeloyl-CoA, namely O-methylation of the malonyl group preferentially while on acyl carrier protein. The enzyme is recognizable as a methyltransferase by homology. [Biosynthesis of cofactors, prosthetic groups, and carriers, Biotin]


Pssm-ID: 273953 [Multi-domain]  Cd Length: 240  Bit Score: 49.21  E-value: 4.19e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502306585   13 DQHASLmdgmyryQRHIydltrKYYLLGRdstIRNLDVAEGGSLLEVGCGTGrnMAFAH--RHFPTAKLFGLDISQEMLI 90
Cdd:TIGR02072  10 DRHAKI-------QREM-----AKRLLAL---LKEKGIFIPASVLDIGCGTG--YLTRAllKRFPQAEFIALDISAGMLA 72

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502306585   91 SARKTFATKATipeFRVADATAFTPREfgvSGFDRILISYALSMIPDWERAVDASIAALNPGGQLHIVDFGQQEglpgwF 170
Cdd:TIGR02072  73 QAKTKLSENVQ---FICGDAEKLPLED---SSFDLIVSNLALQWCDDLSQALSELARVLKPGGLLAFSTFGPGT-----L 141

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*..
gi 502306585  171 RRMLQSWlaKFHVTPRPDLREVLEA--------QAHENNATLVFDAV 209
Cdd:TIGR02072 142 HELRQSF--GQHGLRYLSLDELKALlknsfellTLEEELITLSFDDP 186
MTS pfam05175
Methyltransferase small domain; This domain is found in ribosomal RNA small subunit ...
 45-158 8.85e-07

Methyltransferase small domain; This domain is found in ribosomal RNA small subunit methyltransferase C as well as other methyltransferases.


Pssm-ID: 428349 [Multi-domain]  Cd Length: 170  Bit Score: 47.20  E-value: 8.85e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502306585   45 IRNLDVAEGGSLLEVGCGTGRNMAFAHRHFPTAKLFGLDISQEMLISARKTFAT-KATIPEFRVADATAFTPREfgvsGF 123
Cdd:pfam05175  24 LEHLPKDLSGKVLDLGCGAGVLGAALAKESPDAELTMVDINARALESARENLAAnGLENGEVVASDVYSGVEDG----KF 99

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
gi 502306585  124 DRIL----------ISYALsmipdWERAVDASIAALNPGGQLHIV 158
Cdd:pfam05175 100 DLIIsnppfhaglaTTYNV-----AQRFIADAKRHLRPGGELWIV 139
PLN02233 PLN02233
ubiquinone biosynthesis methyltransferase
 29-185 9.03e-07

ubiquinone biosynthesis methyltransferase


Pssm-ID: 177877 [Multi-domain]  Cd Length: 261  Bit Score: 48.35  E-value: 9.03e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502306585  29 IYDLTRKYYLLGRDSTIRNLDVA-----EGGSLLEVGCGTGrNMAF--AHRHFPTAKLFGLDISQEMLISA--RKTFATK 99
Cdd:PLN02233  45 VYDNLNDLLSLGQHRIWKRMAVSwsgakMGDRVLDLCCGSG-DLAFllSEKVGSDGKVMGLDFSSEQLAVAasRQELKAK 123

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502306585 100 ATIPEFRVADATAfTPREFGVSGFDRILISYALSMIPDWERAVDASIAALNPGGQLHIVDFGQQEGLpgwFRRMLQSWLA 179
Cdd:PLN02233 124 SCYKNIEWIEGDA-TDLPFDDCYFDAITMGYGLRNVVDRLKAMQEMYRVLKPGSRVSILDFNKSTQP---FTTSMQEWMI 199


                 ....*.
gi 502306585 180 KFHVTP 185
Cdd:PLN02233 200 DNVVVP 205
PRK01683 PRK01683
trans-aconitate 2-methyltransferase; Provisional
 60-155 6.31e-06

trans-aconitate 2-methyltransferase; Provisional


Pssm-ID: 234970  Cd Length: 258  Bit Score: 45.70  E-value: 6.31e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502306585  60 GCGTGRNMAFAHRHFPTAKLFGLDISQEMLISARKtfatkaTIP--EFRVADATAFTPREfgvsGFDRILISYALSMIPD 137
Cdd:PRK01683  39 GCGPGNSTELLVERWPAARITGIDSSPAMLAEARS------RLPdcQFVEADIASWQPPQ----ALDLIFANASLQWLPD 108

                         90
                 ....*....|....*...
gi 502306585 138 WERAVDASIAALNPGGQL 155
Cdd:PRK01683 109 HLELFPRLVSLLAPGGVL 126
Pcm COG2518
Protein-L-isoaspartate O-methyltransferase [Posttranslational modification, protein turnover, ...
 48-155 1.65e-05

Protein-L-isoaspartate O-methyltransferase [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 442008 [Multi-domain]  Cd Length: 197  Bit Score: 43.92  E-value: 1.65e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502306585  48 LDVAEGGSLLEVGCGTGRNMA-FAHRhfpTAKLFGLDISQEMLISARKTFAT-KATIPEFRVADATAftprefGVSG--- 122
Cdd:COG2518   62 LDLKPGDRVLEIGTGSGYQAAvLARL---AGRVYSVERDPELAERARERLAAlGYDNVTVRVGDGAL------GWPEhap 132

                         90       100       110
                 ....*....|....*....|....*....|...
gi 502306585 123 FDRILISYALSMIPdweravDASIAALNPGGQL 155
Cdd:COG2518  133 FDRIIVTAAAPEVP------EALLEQLAPGGRL 159
COG2263 COG2263
Predicted RNA methylase [General function prediction only];
52-134 8.45e-05

Predicted RNA methylase [General function prediction only];


Pssm-ID: 441864 [Multi-domain]  Cd Length: 199  Bit Score: 41.81  E-value: 8.45e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502306585  52 EGGSLLEVGCGTGRnMAFAHRHFPTAKLFGLDISQEMLISARKTFATKATIPEFRVADATAFTPRE----------FGV- 120
Cdd:COG2263   45 EGKTVLDLGCGTGM-LAIGAALLGAKKVVGVDIDPEALEIARENAERLGVRVDFIRADVTRIPLGGsvdtvvmnppFGAq 123

                         90
                 ....*....|....*
gi 502306585 121 -SGFDRILISYALSM 134
Cdd:COG2263  124 rRHADRPFLEKALEI 138
arsM PRK11873
arsenite methyltransferase;
52-177 5.72e-04

arsenite methyltransferase;


Pssm-ID: 237007 [Multi-domain]  Cd Length: 272  Bit Score: 39.93  E-value: 5.72e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502306585  52 EGGSLLEVGCGTGrNMAF--AHRHFPTAKLFGLDISQEMLISARKTfATKATIP--EFR--------VADATAftprefg 119
Cdd:PRK11873  77 PGETVLDLGSGGG-FDCFlaARRVGPTGKVIGVDMTPEMLAKARAN-ARKAGYTnvEFRlgeiealpVADNSV------- 147

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 502306585 120 vsgfDRILISYALSMIPDWERAVDASIAALNPGGQLHIVDFGQQEGLPGWFRRMLQSW 177
Cdd:PRK11873 148 ----DVIISNCVINLSPDKERVFKEAFRVLKPGGRFAISDVVLRGELPEEIRNDAELY 201
rsmC PRK09489
16S rRNA (guanine(1207)-N(2))-methyltransferase RsmC;
54-158 7.81e-04

16S rRNA (guanine(1207)-N(2))-methyltransferase RsmC;


Pssm-ID: 181902 [Multi-domain]  Cd Length: 342  Bit Score: 39.92  E-value: 7.81e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502306585  54 GSLLEVGCGTGRNMAFAHRHFPTAKLFGLDISQEMLISARKTFATKATipEFRVADATAFTprefGVSG-FDRIlISYal 132
Cdd:PRK09489 198 GKVLDVGCGAGVLSAVLARHSPKIRLTLSDVSAAALESSRATLAANGL--EGEVFASNVFS----DIKGrFDMI-ISN-- 268

                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 502306585 133 smiPDWERAVDASIAA-----------LNPGGQLHIV 158
Cdd:PRK09489 269 ---PPFHDGIQTSLDAaqtlirgavrhLNSGGELRIV 302
Rsm22 COG5459
Ribosomal protein RSM22 (predicted mitochondrial rRNA methylase) [Translation, ribosomal ...
 52-175 8.80e-04

Ribosomal protein RSM22 (predicted mitochondrial rRNA methylase) [Translation, ribosomal structure and biogenesis]; Ribosomal protein RSM22 (predicted mitochondrial rRNA methylase) is part of the Pathway/BioSystem: Archaeal ribosomal proteins


Pssm-ID: 444210 [Multi-domain]  Cd Length: 306  Bit Score: 39.55  E-value: 8.80e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502306585  52 EGGSLLEVGCGTGRNMAFAHRHFP-TAKLFGLDISQEMLISARKTFATKATIPEFRVADATAFTPREFGVSGFDRILISY 130
Cdd:COG5459   80 APLTVLDVGAGPGTAAWAAADAWPsLLDATLLERSAAALALGRRLARAAANPALETAEWRLADLAAALPAPPADLVVASY 159

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*.
gi 502306585 131 ALSMIPDWERAVDASIAALNPGGQLHIVdfgqqE-GLPGWFRRMLQ 175
Cdd:COG5459  160 VLNELADAARAALVDRLWLAPDGALLIV-----EpGTPAGSRRLLA 200
PCMT pfam01135
Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT);
48-155 1.26e-03

Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT);


Pssm-ID: 395902 [Multi-domain]  Cd Length: 205  Bit Score: 38.50  E-value: 1.26e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502306585   48 LDVAEGGSLLEVGCGTGRNMA-FAHRHFPTAKLFGLDISQEMLISARKTFATKAtiPE---FRVADAT----AFTPrefg 119
Cdd:pfam01135  69 LELKPGMRVLEIGSGSGYLTAcFARMVGEVGRVVSIEHIPELVEIARRNLEKLG--LEnviVVVGDGRqgwpEFAP---- 142

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 502306585  120 vsgFDRILISYALSMIPdweravDASIAALNPGGQL 155
Cdd:pfam01135 143 ---YDAIHVGAAAPEIP------EALIDQLKEGGRL 169
Gcd14 COG2519
tRNA A58 N-methylase Trm61 [Translation, ribosomal structure and biogenesis]; tRNA A58 ...
 48-155 3.70e-03

tRNA A58 N-methylase Trm61 [Translation, ribosomal structure and biogenesis]; tRNA A58 N-methylase Trm61 is part of the Pathway/BioSystem: tRNA modification


Pssm-ID: 442009 [Multi-domain]  Cd Length: 249  Bit Score: 37.45  E-value: 3.70e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502306585  48 LDVAEGGSLLEVGCGTGR-NMAFAHRHFPTAKLFGLDISQEMLISARKTFaTKATIP---EFRVADATaftpREFGVSGF 123
Cdd:COG2519   87 LDIFPGARVLEAGTGSGAlTLALARAVGPEGKVYSYERREDFAEIARKNL-ERFGLPdnvELKLGDIR----EGIDEGDV 161

                         90       100       110
                 ....*....|....*....|....*....|...
gi 502306585 124 DRILISyalsmIPD-WErAVDASIAALNPGGQL 155
Cdd:COG2519  162 DAVFLD-----MPDpWE-ALEAVAKALKPGGVL 188
PLN02336 PLN02336
phosphoethanolamine N-methyltransferase
 48-167 6.97e-03

phosphoethanolamine N-methyltransferase


Pssm-ID: 177970 [Multi-domain]  Cd Length: 475  Bit Score: 37.04  E-value: 6.97e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502306585  48 LDVAEGGSLLEVGCGTGRNMAFAHRHFpTAKLFGLDISQEML-ISARKTFATKATIpEFRVADATAftpREFGVSGFDRI 126
Cdd:PLN02336 262 LDLKPGQKVLDVGCGIGGGDFYMAENF-DVHVVGIDLSVNMIsFALERAIGRKCSV-EFEVADCTK---KTYPDNSFDVI 336

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|.
gi 502306585 127 LISYALSMIPDWERAVDASIAALNPGGQLHIVDFGQQEGLP 167
Cdd:PLN02336 337 YSRDTILHIQDKPALFRSFFKWLKPGGKVLISDYCRSPGTP 377
PRK14103 PRK14103
trans-aconitate 2-methyltransferase; Provisional
 60-155 7.06e-03

trans-aconitate 2-methyltransferase; Provisional


Pssm-ID: 184509  Cd Length: 255  Bit Score: 36.59  E-value: 7.06e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502306585  60 GCGTGRNMAFAHRHFPTAKLFGLDISQEMLISARKTFAtkatipEFRVADATAFTPREfgvsGFDRILISYALSMIPDWE 139
Cdd:PRK14103  37 GCGPGNLTRYLARRWPGAVIEALDSSPEMVAAARERGV------DARTGDVRDWKPKP----DTDVVVSNAALQWVPEHA 106

                         90
                 ....*....|....*.
gi 502306585 140 RAVDASIAALNPGGQL 155
Cdd:PRK14103 107 DLLVRWVDELAPGSWI 122
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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