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Conserved domains on  [gi|502306612|ref|WP_012758332|]
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carbohydrate ABC transporter permease [Rhizobium leguminosarum]

Protein Classification

carbohydrate ABC transporter permease( domain architecture ID 11417684)

carbohydrate ABC transporter permease, part of a periplasmic binding protein (PBP)-dependent ABC transporter may be involved in transport of one or more of a variety of mono-, di-, or polysaccharides, such as trehalose/maltose (MalG) and alginate (AlgM); responsible for translocation of the substrate across the membrane

Gene Ontology:  GO:0055085|GO:0008643
PubMed:  19234479|27273632
TCDB:  3.A.1.1.

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
UgpE COG0395
ABC-type glycerol-3-phosphate transport system, permease component [Carbohydrate transport and ...
 2-279 1.35e-84

ABC-type glycerol-3-phosphate transport system, permease component [Carbohydrate transport and metabolism];


:

Pssm-ID: 440164 [Multi-domain]  Cd Length: 282  Bit Score: 254.63  E-value: 1.35e-84
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502306612   2 SKARTSPIRTGLVHLALSAYTLVALFPVFLTVINSFKDRASIFREPLMIPtPSTFSLVGYQTVLGQGDFATYFQNSFIVT 81
Cdd:COG0395    5 ARRRRRRLGRILLYLLLILLALLFLFPLYWMVVTSFKPPAEIFSGPPSLL-PSEFTLENYRAAFTDGPFGRYLLNSLIVA 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502306612  82 IVSILLVLLFGAMAAFALSEYRFRGNMLLGLYMAIGIMIPIRLGTVAILQGMVAAGLVNTLTALILVYTAQGIPLAIFIL 161
Cdd:COG0395   84 VVSTVLSLLLSSLAAYALARFRFRGRKLLFLLILATLMIPGQVLLIPLYLLFRQLGLLNTYWGLILPYLAFGLPFGIFLL 163

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502306612 162 SEFMRTVSDDLKNAGRIDGLSEYAIFFRLVLPLVRPAMATVAVFTMIPIWNDLWFPLILAPSEATKTVTLGSQIFIGQFV 241
Cdd:COG0395  164 RQFFRSIPRELEEAARIDGASEFRIFWRIVLPLSKPALATVAIFTFIGAWNDFLWPLILLTSPDLRTLPVGLASFQGQYG 243

                        250       260       270
                 ....*....|....*....|....*....|....*...
gi 502306612 242 TNWNAVLAALSLAILPILVLYVIFSRQLIRGITSGAVK 279
Cdd:COG0395  244 TDWGLLMAAAVIATLPVLILFLFLQRYFVRGLTAGAVK 281
 
Name Accession Description Interval E-value
UgpE COG0395
ABC-type glycerol-3-phosphate transport system, permease component [Carbohydrate transport and ...
 2-279 1.35e-84

ABC-type glycerol-3-phosphate transport system, permease component [Carbohydrate transport and metabolism];


Pssm-ID: 440164 [Multi-domain]  Cd Length: 282  Bit Score: 254.63  E-value: 1.35e-84
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502306612   2 SKARTSPIRTGLVHLALSAYTLVALFPVFLTVINSFKDRASIFREPLMIPtPSTFSLVGYQTVLGQGDFATYFQNSFIVT 81
Cdd:COG0395    5 ARRRRRRLGRILLYLLLILLALLFLFPLYWMVVTSFKPPAEIFSGPPSLL-PSEFTLENYRAAFTDGPFGRYLLNSLIVA 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502306612  82 IVSILLVLLFGAMAAFALSEYRFRGNMLLGLYMAIGIMIPIRLGTVAILQGMVAAGLVNTLTALILVYTAQGIPLAIFIL 161
Cdd:COG0395   84 VVSTVLSLLLSSLAAYALARFRFRGRKLLFLLILATLMIPGQVLLIPLYLLFRQLGLLNTYWGLILPYLAFGLPFGIFLL 163

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502306612 162 SEFMRTVSDDLKNAGRIDGLSEYAIFFRLVLPLVRPAMATVAVFTMIPIWNDLWFPLILAPSEATKTVTLGSQIFIGQFV 241
Cdd:COG0395  164 RQFFRSIPRELEEAARIDGASEFRIFWRIVLPLSKPALATVAIFTFIGAWNDFLWPLILLTSPDLRTLPVGLASFQGQYG 243

                        250       260       270
                 ....*....|....*....|....*....|....*...
gi 502306612 242 TNWNAVLAALSLAILPILVLYVIFSRQLIRGITSGAVK 279
Cdd:COG0395  244 TDWGLLMAAAVIATLPVLILFLFLQRYFVRGLTAGAVK 281
PRK10973 PRK10973
sn-glycerol-3-phosphate ABC transporter permease UgpE;
15-273 1.36e-21

sn-glycerol-3-phosphate ABC transporter permease UgpE;


Pssm-ID: 182875 [Multi-domain]  Cd Length: 281  Bit Score: 91.34  E-value: 1.36e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502306612  15 HLALSAYTLVALFPVFLTVINSFKDRASIFREPL-MIPTPSTFSLVGYQTVLGQGD----FATYFQNSFIVTIVSILLVL 89
Cdd:PRK10973  13 HTMLILGIAVILFPLYVAFVAATLDKQAVFAVPMtLIPGTHLLENIANIWVNGVGNnsapFGRMLLNSFVMAFSITVGKI 92

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502306612  90 LFGAMAAFALSEYRFRGNMLLGLYMAIGIMIPIRLGTVAILQGMVAAGLVNTLTALILVYTAQGIplAIFILSEFMRTVS 169
Cdd:PRK10973  93 TVSMLSAFAIVWFRFPLRNLFFWMIFITLMLPVEVRIFPTVEVIANLKMLDSYAGLTLPLMASAT--ATFLFRQFFMTLP 170

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502306612 170 DDLKNAGRIDGLSEYAIFFRLVLPLVRPAMATVAVFTMIPIWNDLWFPLILA--PSEATKTVTLGSQIFIGQFVTNWNAV 247
Cdd:PRK10973 171 DELVEAARIDGASPMRFFWDIVLPLSKTNLAALFVITFIYGWNQYLWPLLIItdVSLGTAVAGIKGMIATGEGTTEWNQV 250

                        250       260
                 ....*....|....*....|....*.
gi 502306612 248 LAALSLAILPILVLYVIFSRQLIRGI 273
Cdd:PRK10973 251 MAAMLLTLIPPVVIVLAMQRAFVRGL 276
TM_PBP2 cd06261
Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding ...
 74-259 2.31e-11

Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and are mainly involved in importing solutes from the environment. The solute is captured by the PBP which delivers it to a gated translocation pathway formed by the two TMs. The two ABCs bind and hydrolyze ATP and drive the transport reaction. For these transporters the ABCs and TMs are on independent polypeptide chains. These systems transport a diverse range of substrates. Most are specific for a single substrate or a group of related substrates; however some transporters are more promiscuous, transporting structurally diverse substrates such as the histidine/lysine and arginine transporter in Enterobacteriaceae. In the latter case, this is achieved through binding different PBPs with different specificities to the TMs. For other promiscuous transporters such as the multiple-sugar transporter Msm of Streptococcus mutans, the PBP has a wide substrate specificity. These transporters include the maltose-maltodextrin, phosphate and sulfate transporters, among others.


Pssm-ID: 119394 [Multi-domain]  Cd Length: 190  Bit Score: 61.53  E-value: 2.31e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502306612  74 FQNSFIVTIVSILLVLLFGAMAAFALSEYRFRGNMLLGLYMAIGIMIPIRLGTVAILQGMVAAGLVNTL----TALILVY 149
Cdd:cd06261    1 LLNTLLLALIATLLALVLGLLLGIILARKRGKLDRLLRRIIDLLLSLPSLVLGLLLVLLFGVLLGWGILpglgLPALILA 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502306612 150 TAQGIPLAIFILSEFMRTVSDDLKNAGRIDGLSEYAIFFRLVLPLVRPAMATVAVFTMIPIWNDLWFPLILAPSEATKTV 229
Cdd:cd06261   81 LLLIAPFARLIRRAALESIPKDLVEAARALGASPWQIFRRIILPLALPPILTGLVLAFARALGEFALVSFLGGGEAPGPG 160

                        170       180       190
                 ....*....|....*....|....*....|
gi 502306612 230 TLGSQIFIGQFVTNWNAVLAALSLAILPIL 259
Cdd:cd06261  161 TGLLLIFAILFPGDLGVAAAVALILLLLSL 190
BPD_transp_1 pfam00528
Binding-protein-dependent transport system inner membrane component; The alignments cover the ...
 89-273 3.93e-07

Binding-protein-dependent transport system inner membrane component; The alignments cover the most conserved region of the proteins, which is thought to be located in a cytoplasmic loop between two transmembrane domains. The members of this family have a variable number of transmembrane helices.


Pssm-ID: 334128 [Multi-domain]  Cd Length: 183  Bit Score: 49.22  E-value: 3.93e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502306612   89 LLFGAMAAFAlseYRFRGNMLLGLYMAIGIMIPIRLGTVAILQGMVAAGLVNTLTALILVYTAQGIPLAIFILSEFMRTV 168
Cdd:pfam00528   2 IPLGIIAALR---RGRRLDRLLRPLIDLLQALPSFVLAILLVVIAILSILGHGILPAIILALLGWAGYARLIRRAALRSL 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502306612  169 SDDLKNAGRIDGLSEYAIFFRLVLPLVRPAMATVAVFTMIPIWNDLWFPLILAPSeaTKTVTLGSQIFIGQFVTNWNAVL 248
Cdd:pfam00528  79 PSDLVEAARALGASRWQIFRKIILPNALPPILTGLALAFGGALGGAVLLEFLGSW--PGLGLLLIEAILGYDYPEIQGPV 156

                         170       180
                  ....*....|....*....|....*
gi 502306612  249 AALSLAILPILVLYVIFSRQLIRGI 273
Cdd:pfam00528 157 LAAALILLLLNLLVDILQRLLDPRV 181
 
Name Accession Description Interval E-value
UgpE COG0395
ABC-type glycerol-3-phosphate transport system, permease component [Carbohydrate transport and ...
 2-279 1.35e-84

ABC-type glycerol-3-phosphate transport system, permease component [Carbohydrate transport and metabolism];


Pssm-ID: 440164 [Multi-domain]  Cd Length: 282  Bit Score: 254.63  E-value: 1.35e-84
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502306612   2 SKARTSPIRTGLVHLALSAYTLVALFPVFLTVINSFKDRASIFREPLMIPtPSTFSLVGYQTVLGQGDFATYFQNSFIVT 81
Cdd:COG0395    5 ARRRRRRLGRILLYLLLILLALLFLFPLYWMVVTSFKPPAEIFSGPPSLL-PSEFTLENYRAAFTDGPFGRYLLNSLIVA 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502306612  82 IVSILLVLLFGAMAAFALSEYRFRGNMLLGLYMAIGIMIPIRLGTVAILQGMVAAGLVNTLTALILVYTAQGIPLAIFIL 161
Cdd:COG0395   84 VVSTVLSLLLSSLAAYALARFRFRGRKLLFLLILATLMIPGQVLLIPLYLLFRQLGLLNTYWGLILPYLAFGLPFGIFLL 163

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502306612 162 SEFMRTVSDDLKNAGRIDGLSEYAIFFRLVLPLVRPAMATVAVFTMIPIWNDLWFPLILAPSEATKTVTLGSQIFIGQFV 241
Cdd:COG0395  164 RQFFRSIPRELEEAARIDGASEFRIFWRIVLPLSKPALATVAIFTFIGAWNDFLWPLILLTSPDLRTLPVGLASFQGQYG 243

                        250       260       270
                 ....*....|....*....|....*....|....*...
gi 502306612 242 TNWNAVLAALSLAILPILVLYVIFSRQLIRGITSGAVK 279
Cdd:COG0395  244 TDWGLLMAAAVIATLPVLILFLFLQRYFVRGLTAGAVK 281
MalG COG3833
ABC-type maltose transport system, permease component MalG [Carbohydrate transport and ...
 1-279 4.10e-55

ABC-type maltose transport system, permease component MalG [Carbohydrate transport and metabolism];


Pssm-ID: 443045 [Multi-domain]  Cd Length: 282  Bit Score: 179.19  E-value: 4.10e-55
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502306612   1 MSKARTSPIRTGLVHLALSAYTLVALFPVFLTVINSFKDRASIFREPLMiptPSTFSLVGYQTVLGQGDFATYFQNSFIV 80
Cdd:COG3833    5 KSRKRRRRLKLGLRHLVLIILAIIALFPILWVVSASFNPGGSLYSSSLI---PENFTLENYKKLFTETPFLRWFLNSLIV 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502306612  81 TIVSILLVLLFGAMAAFALSEYRFRG-NMLLGLYMAIGiMIPIRLGTVAILQGMVAAGLVNTLTALILVYTAQGIPLAIF 159
Cdd:COG3833   82 AVVTAIISVFLAALAAYAFSRFRFKGrKAGLLALLLLQ-MFPAFLALVALYLLLSALGLLNTLLGLILVYLGGAIPFNTW 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502306612 160 ILSEFMRTVSDDLKNAGRIDGLSEYAIFFRLVLPLVRPAMATVAVFTMIPIWNDLWFPLILAPSEATKTVTLGSQIFI-G 238
Cdd:COG3833  161 LMKGYFDTIPKELDEAAKIDGASHFQIFFRIILPLAKPILAVVALLSFIGPWNDFILASVLLRSPENYTLAVGLYSFVsD 240

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|.
gi 502306612 239 QFVTNWNAVLAALSLAILPILVLYVIFSRQLIRGITSGAVK 279
Cdd:COG3833  241 QRNTNWGVFAAGAVLVAIPIVILFLFLQRYLVSGLTAGGVK 281
PRK10973 PRK10973
sn-glycerol-3-phosphate ABC transporter permease UgpE;
15-273 1.36e-21

sn-glycerol-3-phosphate ABC transporter permease UgpE;


Pssm-ID: 182875 [Multi-domain]  Cd Length: 281  Bit Score: 91.34  E-value: 1.36e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502306612  15 HLALSAYTLVALFPVFLTVINSFKDRASIFREPL-MIPTPSTFSLVGYQTVLGQGD----FATYFQNSFIVTIVSILLVL 89
Cdd:PRK10973  13 HTMLILGIAVILFPLYVAFVAATLDKQAVFAVPMtLIPGTHLLENIANIWVNGVGNnsapFGRMLLNSFVMAFSITVGKI 92

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502306612  90 LFGAMAAFALSEYRFRGNMLLGLYMAIGIMIPIRLGTVAILQGMVAAGLVNTLTALILVYTAQGIplAIFILSEFMRTVS 169
Cdd:PRK10973  93 TVSMLSAFAIVWFRFPLRNLFFWMIFITLMLPVEVRIFPTVEVIANLKMLDSYAGLTLPLMASAT--ATFLFRQFFMTLP 170

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502306612 170 DDLKNAGRIDGLSEYAIFFRLVLPLVRPAMATVAVFTMIPIWNDLWFPLILA--PSEATKTVTLGSQIFIGQFVTNWNAV 247
Cdd:PRK10973 171 DELVEAARIDGASPMRFFWDIVLPLSKTNLAALFVITFIYGWNQYLWPLLIItdVSLGTAVAGIKGMIATGEGTTEWNQV 250

                        250       260
                 ....*....|....*....|....*.
gi 502306612 248 LAALSLAILPILVLYVIFSRQLIRGI 273
Cdd:PRK10973 251 MAAMLLTLIPPVVIVLAMQRAFVRGL 276
PotC COG1177
ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport ...
 6-272 1.19e-20

ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism];


Pssm-ID: 440790 [Multi-domain]  Cd Length: 262  Bit Score: 88.24  E-value: 1.19e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502306612   6 TSPIRTGLVHLALSAYTLVALFPVFLTVINSFKDRASifreplMIPTPSTFSLVGYQTVLGQGDFATYFQNSFIVTIVSI 85
Cdd:COG1177    1 SSRLGRLLLRLFLALVLLFLYLPILVLVLYSFNDSWF------LTFPPEGFTLRWYAELFSDPRLLDALLNSLLIALLST 74

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502306612  86 LLVLLFGAMAAFALSEYRFRGNMLLGLYMAIGIMIPIRLGTVAILQGMVAAGLVNTLTALILVYTAQGIPLAIFILSEFM 165
Cdd:COG1177   75 LLATVLGTPAALALARYRFRGRRLLLALLLLPLVVPGIVLGVALLLLFSALGLSGGLWGLILAHVVFTLPFVVLVVLARL 154

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502306612 166 RTVSDDLKNAGRIDGLSEYAIFFRLVLPLVRPAMATVAVFTMIPIWNDLWFPLILAPSEATktvTLGSQIFiGQFVTNWN 245
Cdd:COG1177  155 QGFDPSLEEAARDLGASPWQTFRRVTLPLIAPGILAGALLAFTLSFDEFVITLFLAGPGVT---TLPVYIY-SMIRRGIS 230

                        250       260
                 ....*....|....*....|....*...
gi 502306612 246 AVLAALS-LAILPILVLYVIFSRQLIRG 272
Cdd:COG1177  231 PEINALStLLILLSLLLLLLAERLRRRG 258
malG PRK10998
maltose ABC transporter permease MalG;
1-279 8.07e-16

maltose ABC transporter permease MalG;


Pssm-ID: 182891  Cd Length: 296  Bit Score: 75.52  E-value: 8.07e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502306612   1 MSKARTSPIRTGLVHLALSAYTLVALFPVFLTVINSFkdRASIFREPLMIPtpSTFSLVGYQTVLG----QGD------- 69
Cdd:PRK10998   3 MVQPKSQKLRLFATHLLLLGFIALIMFPLLMVIAISL--REGNFATGSLIP--EQISWEHWKLALGfsveHADgrvtppp 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502306612  70 --FATYFQNSFIVTIVSILLVLLFGAMAAFALSEYRFRGNMLLGLYMAIGIMIPIRLGTVAI------LQGMVAAGLVNT 141
Cdd:PRK10998  79 fpVLLWLWNSVKVAGITAIGIVALSTTCAYAFARMRFKGKATLLKGMLIFQMFPAVLSLVALyalfdrLGQYIPFIGLNT 158

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502306612 142 LTALILVYTAqGIPLAIFILSEFMRTVSDDLKNAGRIDGLSEYAIFFRLVLPLVRPAMATVAVFTMIPIWNDLWFPLILA 221
Cdd:PRK10998 159 HGGVIFAYLG-GIALHVWTIKGYFETIDSSLEEAAALDGATPWQAFRLVLLPLSVPILAVVFILSFIAAITEVPVASLLL 237

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 502306612 222 PSEATKTVTLGSQIFIGQFVTNWNAVLAALSLAILPILVLYVIFSRQLIRGITSGAVK 279
Cdd:PRK10998 238 RDVNSYTLAVGMQQYLNPQNYLWGDFAAAAVLSAIPITVVFLLAQRWLVGGLTAGGVK 295
FbpB COG1178
ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism];
16-271 7.76e-14

ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism];


Pssm-ID: 440791 [Multi-domain]  Cd Length: 538  Bit Score: 70.96  E-value: 7.76e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502306612  16 LALSAYTLVALFPVFLTVinsfkdrASIFREPLMIPTPSTFSLVGYQTVLGQGDFATYFQNSFIVTIVSILLVLLFGAMA 95
Cdd:COG1178  289 LALALCLLLVLLGLLLPL-------LALLLWSLTKALDDNLTLDNYRFVLLDPSLLRALLNSLLLALLAALLAVLLALLL 361

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502306612  96 AFALSEYRFRGNMLLGLYMAIGIMIP---IRLGTVAILQGMVAAGLVNTLTALILVYTAQGIPLAIFILSEFMRTVSDDL 172
Cdd:COG1178  362 AYLVRRRRGRLARLLDRLAMLPYAVPgivLGLGLLLLFNRPLPLLLYGTLAILVLAYVVRFLPFALRSLEAALAQIDPSL 441

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502306612 173 KNAGRIDGLSEYAIFFRLVLPLVRPAMATVAVFTMIPIWNDLWFPLILAPSEatkTVTLGSQIFiGQFVTNWNAVLAALS 252
Cdd:COG1178  442 EEAARSLGASPLRTLRRVTLPLLRPGLLAAALLVFVTSMKELSATLLLRPPG---FETLAVLIY-QLASSGRYGEAAALA 517

                        250
                 ....*....|....*....
gi 502306612 253 LAILPILVLYVIFSRQLIR 271
Cdd:COG1178  518 LLLVLVSLLPVLLLERLLG 536
TM_PBP2 cd06261
Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding ...
 74-259 2.31e-11

Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and are mainly involved in importing solutes from the environment. The solute is captured by the PBP which delivers it to a gated translocation pathway formed by the two TMs. The two ABCs bind and hydrolyze ATP and drive the transport reaction. For these transporters the ABCs and TMs are on independent polypeptide chains. These systems transport a diverse range of substrates. Most are specific for a single substrate or a group of related substrates; however some transporters are more promiscuous, transporting structurally diverse substrates such as the histidine/lysine and arginine transporter in Enterobacteriaceae. In the latter case, this is achieved through binding different PBPs with different specificities to the TMs. For other promiscuous transporters such as the multiple-sugar transporter Msm of Streptococcus mutans, the PBP has a wide substrate specificity. These transporters include the maltose-maltodextrin, phosphate and sulfate transporters, among others.


Pssm-ID: 119394 [Multi-domain]  Cd Length: 190  Bit Score: 61.53  E-value: 2.31e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502306612  74 FQNSFIVTIVSILLVLLFGAMAAFALSEYRFRGNMLLGLYMAIGIMIPIRLGTVAILQGMVAAGLVNTL----TALILVY 149
Cdd:cd06261    1 LLNTLLLALIATLLALVLGLLLGIILARKRGKLDRLLRRIIDLLLSLPSLVLGLLLVLLFGVLLGWGILpglgLPALILA 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502306612 150 TAQGIPLAIFILSEFMRTVSDDLKNAGRIDGLSEYAIFFRLVLPLVRPAMATVAVFTMIPIWNDLWFPLILAPSEATKTV 229
Cdd:cd06261   81 LLLIAPFARLIRRAALESIPKDLVEAARALGASPWQIFRRIILPLALPPILTGLVLAFARALGEFALVSFLGGGEAPGPG 160

                        170       180       190
                 ....*....|....*....|....*....|
gi 502306612 230 TLGSQIFIGQFVTNWNAVLAALSLAILPIL 259
Cdd:cd06261  161 TGLLLIFAILFPGDLGVAAAVALILLLLSL 190
FbpB COG1178
ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism];
1-208 2.00e-10

ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism];


Pssm-ID: 440791 [Multi-domain]  Cd Length: 538  Bit Score: 60.95  E-value: 2.00e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502306612   1 MSKARTSPIRTGLVhLALSAYTLVALFPVFLTVINSFKDRASifreplmiptpstfslvGYQTVLGQGDFATYFQNSFIV 80
Cdd:COG1178    1 MSTRPRRRPRLLLL-LLALLLALLVLLPLLALLLRAFTDGLA-----------------NFWALLSDPYLWRALGNTLLL 62

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502306612  81 TIVSILLVLLFGAMAAFALSEYRFRGNMLLGLYMAIGIMIPIRLGTVAILQGMVAAGLVNT---------------LTAL 145
Cdd:COG1178   63 ALLVTLLSLLLGVPLAWLLARTDFPGRRLLRWLLLLPLALPPYVVALAWIALFGPNGLLNTllralfgleppdiygLGGI 142

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 502306612 146 ILVYTAQGIPLAIFILSEFMRTVSDDLKNAGRIDGLSEYAIFFRLVLPLVRPAMATVAVFTMI 208
Cdd:COG1178  143 ILVLVLFNYPYVYLLLRAALRSIDASLEEAARSLGASPWRAFRRVTLPLLRPAIAAGALLVFL 205
UgpA COG1175
ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism];
17-208 3.79e-10

ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism];


Pssm-ID: 440788 [Multi-domain]  Cd Length: 298  Bit Score: 59.38  E-value: 3.79e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502306612  17 ALSAYTLVALFPVFLTVINSFKDRAsifreplMIPTPSTFslVG---YQTVLGQGDFATYFQNSFIVTIVSILLVLLFGA 93
Cdd:COG1175   27 ALLLLLVFVLYPLLYTLYLSFTDWN-------LLGPPPEF--VGldnYARLFTDPRFWNALGNTLLFTVVSVPLQLVLGL 97

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502306612  94 MAAFALSEyRFRGNmllGLYMAIgIMIPIRLGTVAIlqGMV-------AAGLVNT-------------------LTALIL 147
Cdd:COG1175   98 LLALLLNR-KLRGR---GFFRTL-FFLPWVISPVVV--ALIwkwlfnpDYGLLNAllgalglepinwlgdpslaLPAVII 170

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 502306612 148 VYTAQGIPLAIFILSEFMRTVSDDLKNAGRIDGLSEYAIFFRLVLPLVRPAMATVAVFTMI 208
Cdd:COG1175  171 VTVWKGTGFNMLIFLAGLQSIPRELYEAARIDGASPWQRFRRITLPLLRPTILFVLVLSTI 231
PotB COG1176
ABC-type spermidine/putrescine transport system, permease component I [Amino acid transport ...
 1-271 8.65e-09

ABC-type spermidine/putrescine transport system, permease component I [Amino acid transport and metabolism];


Pssm-ID: 440789 [Multi-domain]  Cd Length: 287  Bit Score: 55.15  E-value: 8.65e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502306612   1 MSKARTSPIRTGLvhLALSAYTLVALF---PVFLTVINSFKDRASIFREPlmiptpSTFSLVGYQTVLGQGDFATYFQNS 77
Cdd:COG1176    1 MSAALRRRLRPLL--LLLPALLWLLLFfvlPLLLLLVYSFTTRDPYGGVV------PGFTLENYARLFTDPLYLKVLLRT 72

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502306612  78 FIVTIVSILLVLLFGAMAAFALSEYRFRGNMLLGLymaiGIMIP------IR-LGTVAIL-------QGMVAAGLV---- 139
Cdd:COG1176   73 LWIALLTTLICLLLGYPIAYFLARAPPRWRNLLLL----LVILPfwtsflVRtYAWIVLLgrngllnSLLLALGLIdepl 148

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502306612 140 ---NTLTALILVYTAQGIPLAIFILSEFMRTVSDDLKNAGRIDGLSEYAIFFRLVLPLVRPAMATVAVFTMIPIWNDLWF 216
Cdd:COG1176  149 rllYTEFAVVIGLVYVYLPFMVLPLYAALEKIDPSLLEAARDLGASPWQTFRRVILPLSLPGIIAGSLLVFIPALGAFVT 228

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 502306612 217 PLILAPseaTKTVTLGSQIFIGQFVT-NWNaVLAALSLAILPILVLYVIFSRQLIR 271
Cdd:COG1176  229 PALLGG---GKVLMIGNLIYQQFLSAlNWP-LAAALAVVLLLIVLLVLLLYLRLLR 280
BPD_transp_1 pfam00528
Binding-protein-dependent transport system inner membrane component; The alignments cover the ...
 89-273 3.93e-07

Binding-protein-dependent transport system inner membrane component; The alignments cover the most conserved region of the proteins, which is thought to be located in a cytoplasmic loop between two transmembrane domains. The members of this family have a variable number of transmembrane helices.


Pssm-ID: 334128 [Multi-domain]  Cd Length: 183  Bit Score: 49.22  E-value: 3.93e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502306612   89 LLFGAMAAFAlseYRFRGNMLLGLYMAIGIMIPIRLGTVAILQGMVAAGLVNTLTALILVYTAQGIPLAIFILSEFMRTV 168
Cdd:pfam00528   2 IPLGIIAALR---RGRRLDRLLRPLIDLLQALPSFVLAILLVVIAILSILGHGILPAIILALLGWAGYARLIRRAALRSL 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502306612  169 SDDLKNAGRIDGLSEYAIFFRLVLPLVRPAMATVAVFTMIPIWNDLWFPLILAPSeaTKTVTLGSQIFIGQFVTNWNAVL 248
Cdd:pfam00528  79 PSDLVEAARALGASRWQIFRKIILPNALPPILTGLALAFGGALGGAVLLEFLGSW--PGLGLLLIEAILGYDYPEIQGPV 156

                         170       180
                  ....*....|....*....|....*
gi 502306612  249 AALSLAILPILVLYVIFSRQLIRGI 273
Cdd:pfam00528 157 LAAALILLLLNLLVDILQRLLDPRV 181
ModB COG4149
ABC-type molybdate transport system, permease component ModB [Inorganic ion transport and ...
 77-204 6.67e-06

ABC-type molybdate transport system, permease component ModB [Inorganic ion transport and metabolism]; ABC-type molybdate transport system, permease component ModB is part of the Pathway/BioSystem: Molybdopterin biosynthesis


Pssm-ID: 443320 [Multi-domain]  Cd Length: 223  Bit Score: 46.20  E-value: 6.67e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502306612  77 SFIVTIVSILLVLLFGAMAAFALSEYRFRGNMLL---------------GLY--MAIGIMIPIrlGtvAILQGMVAAGLV 139
Cdd:COG4149   12 SLKVALIATLLLLLLGIPLAWWLARTRFRGKGLLealvtlplvlpptvlGFYllLLFGRNGPL--G--QLLEELFGISLV 87

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 502306612 140 NTLTALILVYTAQGIPLAIFILSEFMRTVSDDLKNAGRIDGLSEYAIFFRLVLPLVRPAMATVAV 204
Cdd:COG4149   88 FTWTGAVLASVVVSLPLMVQPLRAAFEAVDPRLEEAARTLGASPWRVFFRVTLPLAKPGILAGAV 152
CysU COG0555
ABC-type sulfate transport system, permease component [Inorganic ion transport and metabolism]; ...
 77-204 1.78e-05

ABC-type sulfate transport system, permease component [Inorganic ion transport and metabolism];


Pssm-ID: 440321 [Multi-domain]  Cd Length: 268  Bit Score: 45.13  E-value: 1.78e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502306612  77 SFIVTIVSILLVLLFGAMAAFALSEYRFRGNMLLGLYMAIGIMIPIRLGTVAILQGMVAAGLVNTLTALI---LVYTAQG 153
Cdd:COG0555   59 SLGTALIAALINLVFGLPLAWVLVRYRFPGKRLVDALVDLPFALPTAVAGIALLLLFGPNGWLGQLLAPLgikVAFTPLG 138

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 502306612 154 IPLA-IFILSEFM-RTV-------SDDLKNAGRIDGLSEYAIFFRLVLPLVRPAMATVAV 204
Cdd:COG0555  139 IVLAqTFVSLPFVvRTVqpvleelDPELEEAAATLGASRWQTFRRVILPLLLPALLTGFA 198
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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