|
Name |
Accession |
Description |
Interval |
E-value |
| alt_ValS |
NF000540 |
valine--tRNA ligase; |
14-862 |
0e+00 |
|
valine--tRNA ligase;
Pssm-ID: 467949 [Multi-domain] Cd Length: 827 Bit Score: 1640.41 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502481621 14 PEKPSVDGLEDRWTGVWQEQDTYAFDRARaaslPREQLFTIDTPPPTASGSLHVGHVFGYTQADCMARYKRMTGAEVFYP 93
Cdd:NF000540 1 PEKPSLDGLEAKWAARWEEDGTYAFDRPA----AREEVFSIDTPPPTVSGSLHVGHVFSYTHTDVVARYQRMRGKEVFYP 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502481621 94 IGWDDNGLPTERRVQNYYGVRGDITQPYVEGYEPPQRGGdgkstkAADQQPVSRPNFIELCHELTVEDEKAFEALFRRLG 173
Cdd:NF000540 77 MGWDDNGLPTERRVQNYYGVRCDPSLPYDPDFTPPEKPG------PKDQVPISRRNFIELCERLTAEDEKAFEDLWRRLG 150
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502481621 174 LSLDWNYQYRTIDDNARATSQQAFLRNLQRGEAYSAEAPGLWDVTFQTAVAQAELEARDYPGAYHRIAFHGPQG-DVEVE 252
Cdd:NF000540 151 LSVDWSLTYRTIGDRARRVSQRAFLRNLARGEAYQAEAPTLWDVTFQTAVAQAELEDREYPGAYHRLAFHGADGgPVHIE 230
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502481621 253 TTRPELLPACVALIAHPDDERYQDLFGSTVRTPLFGVEVPVIAHPAAEMDKGAGIAMCCTFGDLTDVTWWRELQLPTRSV 332
Cdd:NF000540 231 TTRPELLPACVALVAHPDDERYQPLFGTTVTSPLFGVEVPVLAHPLAEPDKGSGIAMCCTFGDLTDVTWWRELQLPTRAI 310
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502481621 333 ITRNGRLTGETPAWLADGPGAQLYAEqLATKTVHTARENTVTALRESGELVGEPEKTQRKANFFEKGDKPLEIVTSRQWY 412
Cdd:NF000540 311 IGRDGRLLAETPEWITSEAGRAAYAE-LAGKTVFSAREAVVELLRESGDLDGEPRPIQHPVKFYEKGDKPLEIVSTRQWY 389
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502481621 413 IRNGGRDAELNRALIERGAEVDFHPAYMERRHANWIEGLNGDWLVSRQRFFGVPFPIWYPLDADGEPDHENPITPAEADL 492
Cdd:NF000540 390 IRNGGRDADLREALLARGRELAWHPEHMRVRYENWVEGLNGDWLISRQRFFGVPFPVWYPLDADGEPDYDAPIVPAEDQL 469
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502481621 493 PVDPQTDTAPGFEESQRDQPGGFAADPDVLDTWATSSLSPQIIGGWRNDPELFEMVFPMDMRPQGHDIIRTWLFSTIVRA 572
Cdd:NF000540 470 PVDPSSDVPPGYTEDQRGVPGGFIGDPDVMDTWATSSLTPQIAGGWERDPDLFARVFPMDLRPQGHDIIRTWLFSTVVRA 549
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502481621 573 HHEHGTVPWWNATLNGWILDPDRKKMSKSKGNVVTPVDLLEEHGSDAVRYWAASARQGVDTAFDAQQMKVGRRLAIKLLN 652
Cdd:NF000540 550 HLEHGSLPWRHAAISGWILDPDRKKMSKSKGNVVTPTGLLEQHGSDAVRYWAASARPGTDTAFDETQMKVGRRLAIKLLN 629
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502481621 653 ASKFALGFGEVDGaehpeqLLAQVTEPVDQSLLLELARVVEQATAGFEAWDYTKALEVTEAFFWSFCDDYLELVKARAYG 732
Cdd:NF000540 630 ASKFVLGFGAPAG------DPAAVTEPLDRAMLAALAEVVEQATAAFEAYDYTRALEVTESFFWTFCDDYLELVKERAYG 703
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502481621 733 GDEVEasaATTSARAALRVALDVQLRLLAPFIPFATEEVWSWWHSGSVHRAAWPTADEVRPANLADvnvAGVKPAAAAVL 812
Cdd:NF000540 704 ADGEA---AAASARAALATALSVLLRLFAPFLPFATEEVWSWWQEGSVHRAAWPTADELELPADGD---PALLALASAAL 777
|
810 820 830 840 850
....*....|....*....|....*....|....*....|....*....|
gi 502481621 813 AGIRKAKSEAKLGMRAQVTAMTLAGPAEQRAAARRAWDDVVASGHVVCEV 862
Cdd:NF000540 778 AGIRKAKSEAKVSMRTPVARATVTGPAAQLALLEAAEDDLRAAGRITELV 827
|
|
| valS |
PRK13208 |
valyl-tRNA synthetase; Reviewed |
8-875 |
0e+00 |
|
valyl-tRNA synthetase; Reviewed
Pssm-ID: 237306 [Multi-domain] Cd Length: 800 Bit Score: 1279.36 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502481621 8 TRPAQLPEKPSVDGLEDRWTGVWQEQDTYAFDRARaaslpREQLFTIDTPPPTASGSLHVGHVFGYTQADCMARYKRMTG 87
Cdd:PRK13208 1 KMMPELPKKYDPEELEEKWQKIWEEEGTYKFDPDE-----RKPVYSIDTPPPTVSGSLHIGHVFSYTHTDFIARYQRMRG 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502481621 88 AEVFYPIGWDDNGLPTERRVQNYYGVRGDitqpyvegyeppqrggdgkstkaadqqPVSRPNFIELCHELTVEDEKAFEA 167
Cdd:PRK13208 76 YNVFFPQGWDDNGLPTERKVEKYYGIRKD---------------------------DISREEFIELCRELTDEDEKKFRE 128
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502481621 168 LFRRLGLSLDWNYQYRTIDDNARATSQQAFLRNLQRGEAYSAEAPGLWDVTFQTAVAQAELEARDYPGAYHRIAFHGPQG 247
Cdd:PRK13208 129 LWRRLGLSVDWSLEYQTISPEYRRISQKSFLDLYKKGLIYRAEAPVLWCPRCETAIAQAEVEYREREGKLNYIKFPVEDG 208
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502481621 248 -DVEVETTRPELLPACVALIAHPDDERYQDLFGSTVRTPLFGVEVPVIAHPAAEMDKGAGIAMCCTFGDLTDVTWWRELQ 326
Cdd:PRK13208 209 eEIEIATTRPELLPACVAVVVHPDDERYKHLVGKTAIVPLFGVEVPILADPLVDPDFGTGAVMICTFGDKTDVTWWRELN 288
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502481621 327 LPTRSVITRNGRLTGEtpawladgpgaqlyAEQLATKTVHTARENTVTALRESGeLVGEPEKTQRKANFFEKGDKPLEIV 406
Cdd:PRK13208 289 LPTRIIIDEDGRMTEA--------------AGKLAGLTIEEARKKIVEDLKSGG-LLGKQEPIKHNVKFCERCDTPLEIL 353
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502481621 407 TSRQWYIrnggRDAELNRALIERGAEVDFHPAYMERRHANWIEGLNGDWLVSRQRFFGVPFPIWYPLDADgepdheNPIT 486
Cdd:PRK13208 354 VTRQWFI----KVLDLKEELLERGKEINWYPEHMRVRLENWIEGLNWDWCISRQRYFGTPIPVWYCKDCG------HPIL 423
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502481621 487 PAEADLPVDPQTDTAPGFEESQRDQpGGFAADPDVLDTWATSSLSPQIIGGWRNDPELFEMVFPMDMRPQGHDIIRTWLF 566
Cdd:PRK13208 424 PDEEDLPVDPTKDEPPGYKCPQCGS-PGFEGETDVMDTWATSSITPLIVTGWERDEDLFEKVFPMDLRPQGHDIIRTWLF 502
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502481621 567 STIVRAHHEHGTVPWWNATLNGWILDPDRKKMSKSKGNVVTPVDLLEEHGSDAVRYWAASARQGVDTAFDAQQMKVGRRL 646
Cdd:PRK13208 503 YTILRAYLLTGKLPWKNIMISGMVLDPDGKKMSKSKGNVVTPEELLEKYGADAVRYWAASARLGSDTPFDEKQVKIGRRL 582
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502481621 647 AIKLLNASKFALGFGEVDGAEHPEqllaqVTEPVDQSLLLELARVVEQATAGFEAWDYTKALEVTEAFFWS-FCDDYLEL 725
Cdd:PRK13208 583 LTKLWNASRFVLHFSADPEPDKAE-----VLEPLDRWILAKLAKVVEKATEALENYDFAKALEEIESFFWHvFCDDYLEL 657
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502481621 726 VKARAYGGDEVEasaATTSARAALRVALDVQLRLLAPFIPFATEEVWSWWHSGSVHRAAWPTADEvrpaNLADVNVAGVK 805
Cdd:PRK13208 658 VKSRAYGEDEEE---EQKSARYTLYTVLDTLLRLLAPFLPFITEEVWSWLYGGSVHRASWPEPDE----ELIDEEDEELG 730
|
810 820 830 840 850 860 870
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502481621 806 PAAAAVLAGIRKAKSEAKLGMRAQVTAMTLAGPAEqRAAARRAWDDVVASGHVVCEVAEVDAEELEVRDT 875
Cdd:PRK13208 731 ELAKEILSAVRKYKSEAGLSLNAPLKKVEVYGPAD-LELLEAAEEDLKAAGNIEELELVEGDPELEVEII 799
|
|
| valS |
TIGR00422 |
valyl-tRNA synthetase; The valyl-tRNA synthetase (ValS) is a class I amino acyl-tRNA ligase ... |
23-832 |
6.03e-180 |
|
valyl-tRNA synthetase; The valyl-tRNA synthetase (ValS) is a class I amino acyl-tRNA ligase and is particularly closely related to the isoleucyl tRNA synthetase. [Protein synthesis, tRNA aminoacylation]
Pssm-ID: 273070 [Multi-domain] Cd Length: 861 Bit Score: 541.19 E-value: 6.03e-180
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502481621 23 EDRWTGVWQEQDTYAFDRARAAslPReqlFTIDTPPPTASGSLHVGHVFGYTQADCMARYKRMTGAEVFYPIGWDDNGLP 102
Cdd:TIGR00422 11 EKKWYKKWEKSGFFKPDGNSNK--PP---FCIDIPPPNVTGSLHIGHALNWSIQDIIARYKRMKGYNVLWLPGTDHAGIA 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502481621 103 TERRVQNYYGVRGditqpyvegyeppqrggdgkstKAADQqpVSRPNFIELCHELTVEDEKAFEALFRRLGLSLDWNYQY 182
Cdd:TIGR00422 86 TQVKVEKKLGAEG----------------------KTKHD--LGREEFREKIWEWKEESGGTIKNQIKRLGASLDWSRER 141
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502481621 183 RTIDDNARATSQQAFLRNLQRGEAYSAEAPGLWDVTFQTAVAQAELEARDYPGAYHRIAF---HGPQGDVEVETTRPELL 259
Cdd:TIGR00422 142 FTMDEGLSKAVKEAFVRLYEKGLIYRGEYLVNWDPKLNTAISDIEVEYKEVKGKLYYIRYplaNGSKDYLVVATTRPETM 221
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502481621 260 PACVALIAHPDDERYQDLFGSTVRTPLFGVEVPVIAHPAAEMDKGAGIAMCCTFGDLTDVTWWRELQLPTRSVITRNGRL 339
Cdd:TIGR00422 222 FGDTAVAVHPEDERYKHLIGKKVILPLTGRKIPIIADEYVDMEFGTGAVKVTPAHDFNDYEWGKRHNLEFINILDEDGLL 301
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502481621 340 TGEtpawladgpgaqlyAEQLATKTVHTARENTVTALRESGELVGEPEKTQrKANFFEKGDKPLEIVTSRQWYIRNGgRD 419
Cdd:TIGR00422 302 NEN--------------AGKYQGLTRFEARKKIVEDLKEEGLLVKIEPHTH-NVGTCWRSGTVVEPLLSKQWFVKVE-KL 365
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502481621 420 AELNRALIERGaEVDFHPAYMERRHANWIEGLNgDWLVSRQRFFGVPFPIWYpldadgEPDHENPITPAEADLPVDPqTD 499
Cdd:TIGR00422 366 ADKALEAAEEG-EIKFVPKRMEKRYLNWLRNIK-DWCISRQLIWGHRIPVWY------CKECGEVYVAKEEPLPDDK-TN 436
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502481621 500 TAPGFEESQrdqpggfaaDPDVLDTWATSSLSPQIIGGWRNDPELFEMVFPMDMRPQGHDIIRTWLFSTIVRAHHEHGTV 579
Cdd:TIGR00422 437 TGPSVELEQ---------DTDVLDTWFSSSLWPFSTLGWPDETKDLKKFYPTDLLVTGYDIIFFWVARMIFRSLALTGQV 507
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502481621 580 PWWNATLNGWILDPDRKKMSKSKGNVVTPVDLLEEHGSDAVRYWAAS-ARQGVDTAFDAQQMKVGRRLAIKLLNASKFAL 658
Cdd:TIGR00422 508 PFKEVYIHGLVRDEQGRKMSKSLGNVIDPLDVIEKYGADALRFTLASlVTPGDDINFDWKRVESARNFLNKLWNASRFVL 587
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502481621 659 GFGEVD-GAEHPEQLLaqvtEPVDQSLLLELARVVEQATAGFEAWDYTKALEVTEAFFWS-FCDDYLELVKARAYGGDEV 736
Cdd:TIGR00422 588 MNLSDDlELSGGEEKL----SLADRWILSKLNRTIKEVRKALDKYRFAEAAKALYEFIWNdFCDWYIELVKYRLYNGNEA 663
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502481621 737 EasaaTTSARAALRVALDVQLRLLAPFIPFATEEVWSWWHSG--SVHRAAWPTADE----VRPANLADVnvagvkpaAAA 810
Cdd:TIGR00422 664 E----KKAARDTLYYVLDKALRLLHPFMPFITEEIWQHFKEGadSIMLQSYPVVDAefvdEEAEKAFEL--------LKE 731
|
810 820
....*....|....*....|..
gi 502481621 811 VLAGIRKAKSEAKLGMRAQVTA 832
Cdd:TIGR00422 732 IIVSIRNLKAESNIPPNAPLKV 753
|
|
| ValRS_core |
cd00817 |
catalytic core domain of valyl-tRNA synthetases; Valine amino-acyl tRNA synthetase (ValRS) ... |
52-635 |
2.57e-118 |
|
catalytic core domain of valyl-tRNA synthetases; Valine amino-acyl tRNA synthetase (ValRS) catalytic core domain. This enzyme is a monomer which aminoacylates the 2'-OH of the nucleotide at the 3' of the appropriate tRNA. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains the characteristic class I HIGH and KMSKS motifs, which are involved in ATP binding. ValRS has an insertion in the core domain, which is subject to both deletions and rearrangements. This editing region hydrolyzes mischarged cognate tRNAs and thus prevents the incorporation of chemically similar amino acids.
Pssm-ID: 185677 [Multi-domain] Cd Length: 382 Bit Score: 364.65 E-value: 2.57e-118
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502481621 52 FTIDTPPPTASGSLHVGHVFGYTQADCMARYKRMTGAEVFYPIGWDDNGLPTERRVQNYYGVRGDITQPYvegyeppqrg 131
Cdd:cd00817 3 FVIDTPPPNVTGSLHMGHALNNTIQDIIARYKRMKGYNVLWPPGTDHAGIATQVVVEKKLGIEGKTRHDL---------- 72
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502481621 132 gdgkstkaadqqpvSRPNFIELCHELTVEDEKAFEALFRRLGLSLDWNYQYRTIDDNARATSQQAFLRNLQRGEAYSAEA 211
Cdd:cd00817 73 --------------GREEFLEKCWEWKEESGGKIREQLKRLGASVDWSREYFTMDPGLSRAVQEAFVRLYEKGLIYRDNR 138
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502481621 212 PGLWDVTFQTAVAQAEleardypgayhriafhgpqgdvevettrpellpacvaliahpdderyqdlfgstvrtplfgvev 291
Cdd:cd00817 139 LVNWCPKLRTAISDIE---------------------------------------------------------------- 154
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502481621 292 pviahpaaemdkgagiaMCctfgdltdvtwwrelqlptrsvitrngrltgetpawladgpgaqlyaeqlatktvhtaren 371
Cdd:cd00817 155 -----------------VC------------------------------------------------------------- 156
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502481621 372 tvtalresgelvgepektqrkanffEKGDKPLEIVTSRQWYIRNGgrdaELNRALIERGAEVD--FHPAYMERRHANWIE 449
Cdd:cd00817 157 -------------------------SRSGDVIEPLLKPQWFVKVK----DLAKKALEAVKEGDikFVPERMEKRYENWLE 207
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502481621 450 GLnGDWLVSRQRFFGVPFPIWYPLDADGEPDHEnpitpaEADLPVDPqtdTAPGFEESQRDQpgGFAADPDVLDTWATSS 529
Cdd:cd00817 208 NI-RDWCISRQLWWGHRIPAWYCKDGGHWVVAR------EEDEAIDK---AAPEACVPCGGE--ELKQDEDVLDTWFSSS 275
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502481621 530 LSPQIIGGWRNDPELFEMVFPMDMRPQGHDIIRTWLFSTIVRAHHEHGTVPWWNATLNGWILDPDRKKMSKSKGNVVTPV 609
Cdd:cd00817 276 LWPFSTLGWPEETKDLKKFYPTSLLVTGHDIIFFWVARMIMRGLKLTGKLPFKEVYLHGLVRDEDGRKMSKSLGNVIDPL 355
|
570 580
....*....|....*....|....*..
gi 502481621 610 DLLEEHGSDAVRYWAASA-RQGVDTAF 635
Cdd:cd00817 356 DVIDGYGADALRFTLASAaTQGRDINL 382
|
|
| valS |
PRK05729 |
valyl-tRNA synthetase; Reviewed |
23-855 |
4.50e-96 |
|
valyl-tRNA synthetase; Reviewed
Pssm-ID: 235582 [Multi-domain] Cd Length: 874 Bit Score: 320.90 E-value: 4.50e-96
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502481621 23 EDRWTGVWQEQDTYAfdraraASLPREQLFTIDTPPPTASGSLHVGHVFGYTQADCMARYKRMTGAEVFYPIGWDDNGlp 102
Cdd:PRK05729 15 EAKWYQKWEEKGYFK------PDDNSKKPFSIVIPPPNVTGSLHMGHALNNTLQDILIRYKRMQGYNTLWLPGTDHAG-- 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502481621 103 terrvqnyygvrgdI-TQPYVEgyeppqrggdgkstKAADQQPVSRpnfielcHELTVED--EKAFE-----------AL 168
Cdd:PRK05729 87 --------------IaTQMVVE--------------RQLAAEGKSR-------HDLGREKflEKVWEwkeesggtitnQL 131
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502481621 169 fRRLGLSLDWNYQYRTIDDNARATSQQAFLRNLQRGEAYSAEApgL--WDVTFQTAVAQAELEARDYPGA-YH-RIAFHG 244
Cdd:PRK05729 132 -RRLGASCDWSRERFTMDEGLSKAVREVFVRLYEKGLIYRGKR--LvnWDPKLQTALSDLEVEYKEVKGKlWHiRYPLAD 208
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502481621 245 PQGDVEVETTRPELLPACVALIAHPDDERYQDLFGSTVRTPLFGVEVPVIAHPAAEMDKGAGiAMCCTFG-DLTDVtwwr 323
Cdd:PRK05729 209 GSDYLVVATTRPETMLGDTAVAVNPEDERYKHLIGKTVILPLVGREIPIIADEYVDPEFGTG-AVKITPAhDPNDF---- 283
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502481621 324 EL----QLPTRSVITRNGRLTGEtpawladgpgaqlyAEQLATKTVHTARENTVTALRESGELVGEpEKTQRKANFFEKG 399
Cdd:PRK05729 284 EVgkrhNLPMINIMDEDGTINEN--------------PGEYQGLDRFEARKAIVADLEELGLLVKI-EPHTHSVGHSDRS 348
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502481621 400 DKPLEIVTSRQWYIRNggrdAELNRALIE--RGAEVDFHPAYMERRHANWIEGLNgDWLVSRQRFFGVPFPIWYplDADG 477
Cdd:PRK05729 349 GVVIEPYLSDQWFVKM----KPLAKPALEavENGEIKFVPERWEKTYFHWMENIQ-DWCISRQLWWGHRIPAWY--DEDG 421
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502481621 478 E--PDHENPITPAEADLpvdpqtdtapgfeeSQrdqpggfaaDPDVLDTWATSSLSPQIIGGWRNDPELFEMVFPMDMRP 555
Cdd:PRK05729 422 EvyVGREEPEAREKALL--------------TQ---------DEDVLDTWFSSALWPFSTLGWPEKTEDLKRFYPTSVLV 478
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502481621 556 QGHDIIRTW----LFSTIvrahHEHGTVPWWNATLNGWILDPDRKKMSKSKGNVVTPVDLLEEHGSDAVRY-WAASARQG 630
Cdd:PRK05729 479 TGFDIIFFWvarmIMMGL----HFTGQVPFKDVYIHGLVRDEQGRKMSKSKGNVIDPLDLIDKYGADALRFtLAALASPG 554
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502481621 631 VDTAFDAQQMKVGRRLAIKLLNASKFALGFGEVDGAEHPEQLLAQvtEPVDQSLLLELARVVEQATAGFEAWDYTKALEV 710
Cdd:PRK05729 555 RDIRFDEERVEGYRNFANKLWNASRFVLMNLEGADVGELPDPEEL--SLADRWILSRLNRTVAEVTEALDKYRFDEAARA 632
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502481621 711 TEAFFWS-FCDDYLELVKARAYGGDEVEasaattsARAALRVALDVQLRLLAPFIPFATEEVWSWWHSGSVHR----AAW 785
Cdd:PRK05729 633 LYEFIWNeFCDWYLELAKPVLQEAAKRA-------TRATLAYVLEQILRLLHPFMPFITEELWQKLAPLGIEEsimlAPW 705
|
810 820 830 840 850 860 870
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502481621 786 PTADEVRPANlADVNVAGVKpaaaAVLAGIRKAKSEAKLGMRAQVTAMtLAGPAEQRAAARRAWDDVVAS 855
Cdd:PRK05729 706 PEADEAIDEA-AEAEFEWLK----ELITAIRNIRAEMNIPPSKKLPLL-LKGADAEDRARLEANEAYIKR 769
|
|
| tRNA-synt_1 |
pfam00133 |
tRNA synthetases class I (I, L, M and V); Other tRNA synthetase sub-families are too ... |
30-636 |
1.36e-90 |
|
tRNA synthetases class I (I, L, M and V); Other tRNA synthetase sub-families are too dissimilar to be included.
Pssm-ID: 459685 [Multi-domain] Cd Length: 602 Bit Score: 299.33 E-value: 1.36e-90
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502481621 30 WQEQDtyAFDRARAASLPREQlFTIDTPPPTASGSLHVGHVFGYTQADCMARYKRMTGAEVFYPIGWDDNGLPTERRVQN 109
Cdd:pfam00133 6 WDEQG--YFKPELEKRKGKPS-FTIHDGPPNATGSLHIGHALAKTLKDIVIRYKRMKGYYVLWVPGWDHHGLPTEQVVEK 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502481621 110 YYGVRGditqpyvegyeppqrggdgkstkAADQQPVSRPNFIELCHELTVEDEKAFEALFRRLGLSLDWNYQYRTIDDNA 189
Cdd:pfam00133 83 KLGIKE-----------------------KKTRHKYGREEFREKCREWKMEYADEIRKQFRRLGRSIDWDREYFTMDPEL 139
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502481621 190 RATSQQAFLRNLQRGEAYSAEAPGLWDVTFQTAVAQAELEARDYPGAYHRIAFH---GPQGDVEVETTRPELLPACVALI 266
Cdd:pfam00133 140 EAAVWEVFVRLHDKGLIYRGKKLVNWSPALNTALSNLEVEYKDVKGPSIHVAFPladDEGASLVIWTTTPWTLPGNTAVA 219
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502481621 267 AHPD-------------------------------DERYQDLFGSTVRTPLFGVEVPVIAHPAAEMDKGAGIAMCCTFGD 315
Cdd:pfam00133 220 VNPEfdyvitgegyilaeallkslykkgtdkkileDFRGKELEGKEAIHPFVNREIPIITDDYVDMEFGTGAVHIAPAHG 299
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502481621 316 LTDVTWWRELQLPTRSVITRNGRLTGETPAWladgpgAQLYaeqlatktVHTARENTVTALRESGELVgEPEKTQRKANF 395
Cdd:pfam00133 300 ENDYEVGQRHNLEVINPVDDDGTFTEEAPDF------QGVY--------RFDARKKIVELLTEKGLLL-KIEPFTHSYPF 364
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502481621 396 FEKGDKPLEIVTSRQWYIRNggrdAELNRALIERGAEVDFHPAYMERRHANWIEGLnGDWLVSRQRFFGVPFPIWYplDA 475
Cdd:pfam00133 365 CWRSGTPIIPRATPQWFVRM----DELADQALEAVEKVQFVPKSGEKRYFNWLANI-QDWCISRQRWWGHPIPAWV--SK 437
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502481621 476 DGE---PDHENPITPAEADLPVDPQTDTAPGFEESQRDQPGGFAADPDVLDTWATSSLSPQIIGGW-RNDPELFEMVFPM 551
Cdd:pfam00133 438 DTEevvCRGELFELVAGRFEEEGSIKWLHREAKDKLGYGKGTLEQDEDVLDTWFSSGSWPFSTLGWpFVNTEEFKKFFPA 517
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502481621 552 DMRPQGHDIIRTWLFSTIVRAHHEHGTVPWWNATLNGWILDPDRKKMSKSKGNVVTPVDLLEEHGSDAVRYWAASARQGV 631
Cdd:pfam00133 518 DMLLEGSDQTRGWFYRMIMLSTALTGSVPFKNVLVHGLVRDEQGRKMSKSLGNVIDPLDVIDKYGADALRLWLANSDYGR 597
|
....*
gi 502481621 632 DTAFD 636
Cdd:pfam00133 598 DINLS 602
|
|
| ValS |
COG0525 |
Valyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Valyl-tRNA synthetase ... |
23-855 |
1.66e-89 |
|
Valyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Valyl-tRNA synthetase is part of the Pathway/BioSystem: Aminoacyl-tRNA synthetases
Pssm-ID: 440291 [Multi-domain] Cd Length: 877 Bit Score: 303.13 E-value: 1.66e-89
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502481621 23 EDRWTGVWQEQDtyAFdRARAASlPREQlFTIDTPPPTASGSLHVGHVFGYTQADCMARYKRMTGAEVFYPIGWDDNGlp 102
Cdd:COG0525 13 EAKWYQYWEENG--YF-KADPDS-DKEP-FTIVIPPPNVTGSLHMGHALNNTLQDILIRYKRMQGYNTLWQPGTDHAG-- 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502481621 103 terrvqnyygvrgdI-TQPYVEgyeppqrggdgkstKAADQQPVSRpnfielcHELTVED--EKAFE----------ALF 169
Cdd:COG0525 86 --------------IaTQAVVE--------------RQLAEEGKSR-------HDLGREKflERVWEwkeesggtitNQL 130
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502481621 170 RRLGLSLDWNYQYRTIDDNARATSQQAFLRnLqrgeaYSAeapGL---------WDVTFQTAVAQAELEARDYPGA-YH- 238
Cdd:COG0525 131 RRLGASCDWSRERFTMDEGLSKAVREVFVR-L-----YEK---GLiyrgkrlvnWDPKLKTALSDLEVEHEEVKGHlWHi 201
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502481621 239 RIAFHGPQGDVEVETTRPELLPACVALIAHPDDERYQDLFGSTVRTPLFGVEVPVIAHPAAEMDKGAGiAMCCT----FG 314
Cdd:COG0525 202 RYPLADGSGYIVVATTRPETMLGDTAVAVHPEDERYKHLIGKTVILPLVGREIPIIADEYVDPEFGTG-AVKITpahdPN 280
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502481621 315 DLtdvtwwrEL----QLPTRSVITRNGRLTGEtpawladgpgaqlyAEQLATKTVHTARENTVTALRESGELVGEpEKTQ 390
Cdd:COG0525 281 DF-------EVgkrhNLPMINILDEDGTINEN--------------AGKYRGLDRFEARKAIVADLEELGLLVKV-EPHK 338
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502481621 391 RKANFFEKGDKPLEIVTSRQWYIRNggrdAELNRALIE--RGAEVDFHPAYMERRHANWIEGLNgDWLVSRQRFFGVPFP 468
Cdd:COG0525 339 HSVGHSDRSGTVIEPYLSDQWFVKM----KPLAKPAIEavEDGEIKFVPERWEKTYFHWMENIR-DWCISRQLWWGHRIP 413
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502481621 469 IWYplDADGEpdhenpITPAEADLPVDPQTDTAPgfeesqrdqpggFAADPDVLDTWATSSLSPQIIGGWRNDPELFEMV 548
Cdd:COG0525 414 AWY--CPDGE------VYVARTEPEACAKAGSVN------------LTQDEDVLDTWFSSALWPFSTLGWPEKTEDLKYF 473
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502481621 549 FPMDMRPQGHDIIRTW----LFSTIvrahHEHGTVPWWNATLNGWILDPDRKKMSKSKGNVVTPVDLLEEHGSDAVRY-W 623
Cdd:COG0525 474 YPTSVLVTGFDIIFFWvarmIMMGL----HFTGEVPFKDVYIHGLVRDEQGRKMSKSKGNVIDPLDLIDKYGADALRFtL 549
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502481621 624 AASARQGVDTAFDAQQMKVGRRLAIKLLNASKFALGFGEvdGAEHPEQLLAQVTEPVDQSLLLELARVVEQATAGFEAWD 703
Cdd:COG0525 550 AALASPGRDIKFDEERVEGYRNFANKLWNASRFVLMNLE--GFDPGLDPDPEELSLADRWILSRLNKTIAEVTEALEKYR 627
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502481621 704 YTKALEVTEAFFWS-FCDDYLELVKARAYGGDEVEasaaTTSARAALRVALDVQLRLLAPFIPFATEEVWS---WWHSG- 778
Cdd:COG0525 628 FDEAAQALYDFVWNeFCDWYLELAKPRLYGGDEAA----KRETRATLVYVLEQILRLLHPFMPFITEEIWQklpPRKEGe 703
|
810 820 830 840 850 860 870
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 502481621 779 SVHRAAWPTADEVRPANLADVNVAGVKpaaaAVLAGIRKAKSEAKLGMRAQVTAMtLAGPAEQRAAARRAWDDVVAS 855
Cdd:COG0525 704 SIMLAPWPEADEELIDEEAEAEFEWLK----EVISAIRNIRAEMNIPPSKKLPLL-LKGADEADRARLEENAAYIKR 775
|
|
| valS |
PRK14900 |
valyl-tRNA synthetase; Provisional |
22-832 |
2.44e-84 |
|
valyl-tRNA synthetase; Provisional
Pssm-ID: 237855 [Multi-domain] Cd Length: 1052 Bit Score: 292.28 E-value: 2.44e-84
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502481621 22 LEDRWTGVWQEQDTYAFDRARAASLPreqlFTIDTPPPTASGSLHVGHVFGYTQADCMARYKRMTGAEVFYPIGWDDNGL 101
Cdd:PRK14900 24 VEARWYPFWQERGYFHGDEHDRTRPP----FSIVLPPPNVTGSLHLGHALTATLQDVLIRWKRMSGFNTLWLPGTDHAGI 99
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502481621 102 PTERRVQNyygvrgditqpyvegyeppqrggDGKSTKAADQQPVSRPNFIELCHELTVEDEKAFEALFRRLGLSLDWNYQ 181
Cdd:PRK14900 100 ATQMIVEK-----------------------ELKKTEKKSRHDLGREAFLERVWAWKEQYGSRIGEQHKALGASLDWQRE 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502481621 182 YRTIDDNARATSQQAFLRNLQRGEAYSAEAPGLWDVTFQTAVAQAELEARD-YPGAYHRIAFHGPQGDVE--VETTRPEL 258
Cdd:PRK14900 157 RFTMDEGLSRAVREVFVRLHEEGLIYREKKLINWCPDCRTALSDLEVEHEEaHQGELWSFAYPLADGSGEivVATTRPET 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502481621 259 LPACVALIAHPDDERYQDLFGSTVRTPLFGVEVPVIAHpAAEMDK--GAGIAMCCTFGDLTDVTWWRELQLPTRSVITRN 336
Cdd:PRK14900 237 MLGDTAVAVHPLDPRYMALHGKKVRHPITGRTFPIVAD-AILVDPkfGTGAVKVTPAHDFNDFEVGKRHGLEMITVIGPD 315
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502481621 337 GRLTGETpawladGPgaqlyaeqLATKTVHTARENTVTALRESGELVG-EPEK-----TQRKANFFEkgdkPLeivTSRQ 410
Cdd:PRK14900 316 GRMTAEA------GP--------LAGLDRFEARKEVKRLLAEQGLDRGaKPHVlplgrCQRSATILE----PL---LSDQ 374
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502481621 411 WYIrnggRDAELNRALIE--RGAEVDFHPAYMERRHANWIEGLNgDWLVSRQRFFGVPFPIWYPLDAdgepdheNPITPA 488
Cdd:PRK14900 375 WYV----RIEPLARPAIEavEQGRTRFIPEQWTNTYMAWMRNIH-DWCISRQLWWGHQIPAWYCPDG-------HVTVAR 442
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502481621 489 EAdlpvdPQTDTAPGFEEsqrdqpggFAADPDVLDTWATSSLSPQIIGGWRNDPELFEMVFPMDMRPQGHDIIRTWLFST 568
Cdd:PRK14900 443 ET-----PEACSTCGKAE--------LRQDEDVLDTWFSSGLWPFSTMGWPEQTDTLRTFYPTSVMETGHDIIFFWVARM 509
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502481621 569 IVRAHHEHGTVPWWNATLNGWILDPDRKKMSKSKGNVVTPVDLLEEHGSDAVRY-WAASARQGVDTAFDAQQMKVGRRLA 647
Cdd:PRK14900 510 MMMGLHFMGEVPFRTVYLHPMVRDEKGQKMSKTKGNVIDPLVITEQYGADALRFtLAALTAQGRDIKLAKERIEGYRAFA 589
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502481621 648 IKLLNASKFALgfGEVDGAEHPEQLLAQVT-EPVDQSLLLELARVVEQATAGFEAWDYTKALEVTEAFFWS-FCDDYLEL 725
Cdd:PRK14900 590 NKLWNASRFAL--MNLSGYQERGEDPARLArTPADRWILARLQRAVNETVEALEAFRFNDAANAVYAFVWHeLCDWYIEL 667
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502481621 726 VKARAYGGDEveasAATTSARAALRVALDVQLRLLAPFIPFATEEVwswWHSGSVHRAAWPTADEVRPANLADVNVAGVK 805
Cdd:PRK14900 668 AKEALASEDP----EARRSVQAVLVHCLQTSYRLLHPFMPFITEEL---WHVLRAQVGASAWADSVLAAEYPRKGEADEA 740
|
810 820 830
....*....|....*....|....*....|..
gi 502481621 806 PAAA-----AVLAGIRKAKSEAKLGMRAQVTA 832
Cdd:PRK14900 741 AEAAfrpvlGIIDAVRNIRGEMGIPWKVKLGA 772
|
|
| ileS |
TIGR00392 |
isoleucyl-tRNA synthetase; The isoleucyl tRNA synthetase (IleS) is a class I amino acyl-tRNA ... |
30-822 |
1.01e-78 |
|
isoleucyl-tRNA synthetase; The isoleucyl tRNA synthetase (IleS) is a class I amino acyl-tRNA ligase and is particularly closely related to the valyl tRNA synthetase. This model may recognize IleS from every species, including eukaryotic cytosolic and mitochondrial forms. [Protein synthesis, tRNA aminoacylation]
Pssm-ID: 273054 [Multi-domain] Cd Length: 861 Bit Score: 273.10 E-value: 1.01e-78
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502481621 30 WQEQDTYAFDRARAAslpREQLFTIDTPPPTASGSLHVGHVFGYTQADCMARYKRMTGAEVFYPIGWDDNGLPTERRVQN 109
Cdd:TIGR00392 19 WQENDIFEKVKKLNK---GKPEFIFHDGPPYANGSIHLGHALNKILKDIILRYKTMQGFNVTRKPGWDTHGLPIEHKVEK 95
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502481621 110 YYGVRGditqpyvegyeppqrggdgkstkAADQQPVSRPNFIELCHELTVEDEKAFEALFRRLGLSLDWNYQYRTIDDNA 189
Cdd:TIGR00392 96 KLGISG-----------------------KKEISSLEIEEFREKCREFALKQIEEQREQFQRLGVWGDWENPYKTMDPSY 152
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502481621 190 RATSQQAFLRNLQRGEAYSAEAPGLWDVTFQTAVAQAELEardYPGAYHR-------IAFHGPQGDVE----------VE 252
Cdd:TIGR00392 153 EESQWWLFKEAHEKGLLYRGLKPVYWSPRCRTALAEAEVE---YKENYKDvkdpsiyVKFPVKKDKKTylkvklssllIW 229
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502481621 253 TTRPELLPACVALIAHPD-----------DERY--------------------------QDLFGSTVRTPLFG-VEVPVI 294
Cdd:TIGR00392 230 TTTPWTLPSNLAIAVHPDfeyalvqdntkVEYFilakklveklynkagsdyeiiktfkgSDLEGLEYEHPLYDfVSQLKE 309
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502481621 295 AHPAAEM------DKGAGIAMCC-TFGdLTDVTWWRELQLPTRSVITRNGRLTGETPAWladgpgaQLYAEQLATKTVHT 367
Cdd:TIGR00392 310 GAPVVIGgdhvttEDGTGIVHTApGHG-EEDYEIGKKYGLEVLSPVDEKGVYTEGVNDF-------QGRFVKDADKDIIK 381
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502481621 368 ARENTVTALRESGELVGEpEKTQRKANFFEKGDKPLEIVTSRQWYIRNGGRDAELNRAlIERgaeVDFHPAYMERRHANW 447
Cdd:TIGR00392 382 ANKIIIEQLKDKGLLLKA-EKITHSYPHCWRTKTPVIYRATEQWFIKTKDIKDQMLEQ-IKK---VNWVPEWGEGRFGNW 456
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502481621 448 IEGlNGDWLVSRQRFFGVPFPIWYPlDADGEP------DH-ENPITPAEADLPVD----PQTDtaPGFEESQrdQPGGFA 516
Cdd:TIGR00392 457 LEN-RPDWCISRQRYWGIPIPIWYC-EDTGEPivvgsiEElIELIELKGIDAWFEdlhrDFLD--KITLKSG--DGGEYR 530
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502481621 517 ADPDVLDTWATSSLSPQIIGGWRNDPELFEMVFPMDMRPQGHDIIRTWLFSTIVRAHHEHGTVPWWNATLNGWILDPDRK 596
Cdd:TIGR00392 531 RVPDVLDVWFDSGSMPYASIHYPFENEKFKEVFPADFILEGSDQTRGWFYSSLAIGTALFGQAPYKNVITHGFTLDEKGR 610
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502481621 597 KMSKSKGNVVTPVDLLEEHGSDAVRYWAASARQGVDTAFDAQQMK-VGRRLAIKLLNASKFALGFGEVDGAEHPEQLLAQ 675
Cdd:TIGR00392 611 KMSKSLGNVVDPLKVINKYGADILRLYVASSDPWEDLRFSDEILKqVVEKYRKIRWNTYRFLLTYANLDKFDPLFNSVAV 690
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502481621 676 VTEP-VDQSLLLELARVVEQATAGFEAWDYTKALEVTEAFF------WsfcddYLELVKARAYGGDEVEasaATTSARAA 748
Cdd:TIGR00392 691 EKFPeEDRWILSRLNSLVEEVNEALEKYNFHKVLRALQDFIveelsnW-----YIRIIRDRLYCEAKDN---DKRAAQTT 762
|
810 820 830 840 850 860 870
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 502481621 749 LRVALDVQLRLLAPFIPFATEEVWSWWHSG----SVHRAAWPTADEVRPANLADVNVAGVKPAAAAVLAgIRKAKSEA 822
Cdd:TIGR00392 763 LYYALLTLVRLLAPFLPHTAEEIYQNLPGGeeeeSVHLNLWPEVDEEFIDEALEANMAIVREIVEAFLA-LRDAANKK 839
|
|
| PLN02943 |
PLN02943 |
aminoacyl-tRNA ligase |
23-841 |
1.83e-77 |
|
aminoacyl-tRNA ligase
Pssm-ID: 215509 [Multi-domain] Cd Length: 958 Bit Score: 271.43 E-value: 1.83e-77
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502481621 23 EDRWTGVWQEQDTYAFDRARAASlPreqlFTIDTPPPTASGSLHVGHVFGYTQADCMARYKRMTGAEVFYPIGWDDNGLP 102
Cdd:PLN02943 66 EERIYNWWESQGYFKPNFDRGGD-P----FVIPMPPPNVTGSLHMGHAMFVTLEDIMVRYNRMKGRPTLWIPGTDHAGIA 140
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502481621 103 TERRVQNYYGVRGditqpyvegyeppqrggdgksTKAADqqpVSRPNFIELCHELTVEDEKAFEALFRRLGLSLDWNYQY 182
Cdd:PLN02943 141 TQLVVEKMLASEG---------------------IKRTD---LGRDEFTKRVWEWKEKYGGTITNQIKRLGASCDWSRER 196
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502481621 183 RTIDDNARATSQQAFLRNLQRGEAYSAEAPGLWDVTFQTAVAQAELEARDYPGAYHRIAFH---GPQGDVEVETTRPELL 259
Cdd:PLN02943 197 FTLDEQLSRAVVEAFVRLHEKGLIYQGSYMVNWSPNLQTAVSDLEVEYSEEPGTLYYIKYRvagGSEDFLTIATTRPETL 276
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502481621 260 PACVALIAHPDDERYQDLFGSTVRTPL-FGVEVPVIAHPAAEMDKGAGIAMCCTFGDLTDVTWWRELQLPTRSVITRNGR 338
Cdd:PLN02943 277 FGDVAIAVNPEDDRYSKYIGKMAIVPMtYGRHVPIIADRYVDKDFGTGVLKISPGHDHNDYLLARKLGLPILNVMNKDGT 356
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502481621 339 LTgetpawlaDGPGAQLYAeqlatktvhtARENTVTALRESGELVGEPEKTQRKANFfEKGDKPLEIVTSRQWYIRnggR 418
Cdd:PLN02943 357 LN--------EVAGLYWFE----------AREKLWSDLEETGLAVKKEPHTLRVPRS-QRGGEVIEPLVSKQWFVT---M 414
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502481621 419 DAELNRAL--IERGaEVDFHPAYMERRHANWIEGLNgDWLVSRQRFFGVPFPIWYPLDADGEPDHENPITPAEAdlpvdp 496
Cdd:PLN02943 415 EPLAEKALkaVENG-ELTIIPERFEKIYNHWLSNIK-DWCISRQLWWGHRIPVWYIVGKDCEEDYIVARSAEEA------ 486
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502481621 497 qtdtapgfEESQRDQPGG---FAADPDVLDTWATSSLSPQIIGGWRN-DPELFEMVFPMDMRPQGHDIIRTWLFSTIVRA 572
Cdd:PLN02943 487 --------LEKAREKYGKdveIYQDPDVLDTWFSSALWPFSTLGWPDvSAEDFKKFYPTTVLETGHDILFFWVARMVMMG 558
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502481621 573 HHEHGTVPWWNATLNGWILDPDRKKMSKSKGNVVTPVDLLEEHGSDAVRYWAASARQGVDTAFDAQQMKVGRRLAIKLLN 652
Cdd:PLN02943 559 IEFTGTVPFSYVYLHGLIRDSQGRKMSKTLGNVIDPLDTIKEFGTDALRFTLALGTAGQDLNLSTERLTSNKAFTNKLWN 638
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502481621 653 ASKFAL----GFGEVDGAEH-------PEQLLAQVTEPvDQSLLLELARVVEQATAGFEAWDYTKALEVTEAFFWS-FCD 720
Cdd:PLN02943 639 AGKFVLqnlpSQSDTSAWEHilackfdKEESLLSLPLP-ECWVVSKLHELIDSVTTSYDKYFFGDVGREIYDFFWSdFAD 717
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502481621 721 DYLELVKARAYGGdevEASAATTSARAALRVALDVQLRLLAPFIPFATEEVWswwhSGSVHR------AAWPTADevRPA 794
Cdd:PLN02943 718 WYIEASKTRLYHS---GDNSALSRAQAVLLYVFENILKLLHPFMPFVTEELW----QALPYRkealivSPWPQTS--LPK 788
|
810 820 830 840
....*....|....*....|....*....|....*....|....*..
gi 502481621 795 NLADVNVAgvkPAAAAVLAGIRKAKSEAKLGMRAQVTAMTLAGPAEQ 841
Cdd:PLN02943 789 DLKSIKRF---ENLQSLTRAIRNARAEYSVEPAKRISASIVASAEVI 832
|
|
| PTZ00419 |
PTZ00419 |
valyl-tRNA synthetase-like protein; Provisional |
23-772 |
6.35e-69 |
|
valyl-tRNA synthetase-like protein; Provisional
Pssm-ID: 240411 [Multi-domain] Cd Length: 995 Bit Score: 247.61 E-value: 6.35e-69
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502481621 23 EDRWTGVWqEQDTYAFDRARAASLPREQLFTIDTPPPTASGSLHVGHVFGYTQADCMARYKRMTGAEVFYPIGWDDNGLP 102
Cdd:PTZ00419 34 ESGWYEWW-EKSGFFKPAEDAKSLNSGKKFVIVLPPPNVTGYLHIGHALTGAIQDSLIRYHRMKGDETLWVPGTDHAGIA 112
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502481621 103 T----ERRVqnyygvrgditqpYVEgyeppqrggDGKStkaadQQPVSRPNFIELCHELTVEDEKAFEALFRRLGLSLDW 178
Cdd:PTZ00419 113 TqvvvEKKL-------------MKE---------ENKT-----RHDLGREEFLKKVWEWKDKHGNNICNQLRRLGSSLDW 165
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502481621 179 NYQYRTIDDNARATSQQAFLRNLQRGEAYSAEAPGLWDVTFQTAVAQAELEARDYP----------------GAYHRIAF 242
Cdd:PTZ00419 166 SREVFTMDEQRSKAVKEAFVRLYEDGLIYRDTRLVNWCCYLKTAISDIEVEFEEIEkptkitipgydkkvevGVLWHFAY 245
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502481621 243 H---GPQGDVEVETTRPELLPACVALIAHPDDERYQDLFGSTVRTPLF-GVEVPVIAHPA-AEMDKGAGIAMCCTFGDLT 317
Cdd:PTZ00419 246 PledSGQEEIVVATTRIETMLGDVAVAVHPKDERYKKLHGKELIHPFIpDRKIPIIADDElVDMEFGTGAVKITPAHDPN 325
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502481621 318 DVTWWRELQLPTRSVITRNGRLTGETpawladGPgaqlyaeqlaTKTVH--TARENTVTALRESGELVG-EPEKTQ---- 390
Cdd:PTZ00419 326 DYEIAKRHNLPFINIFTLDGKINENG------GE----------FAGMHrfDCRRKIEEELKEMGLLRDkVPNPMRlprc 389
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502481621 391 -RKANFFEKGDKPleivtsrQWYIRNggrdAELNRALIE--RGAEVDFHPAYMERRHANWIEGLNgDWLVSRQRFFGVPF 467
Cdd:PTZ00419 390 sRSGDIVEPMLIP-------QWYVNC----KDMAKRAVEavRNGELKIIPSSHENVWYHWLENIQ-DWCISRQLWWGHRI 457
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502481621 468 PIWY-------PLDADGEP-----DHENPITPAEADLPVdpqtdTAPGFEESQrdqpggfaaDPDVLDTWATSSLSPQII 535
Cdd:PTZ00419 458 PAYRviskgpeTDPSDEEPwvvarSEEEALEKAKKKFGL-----SEEDFELEQ---------DEDVLDTWFSSGLFPFST 523
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502481621 536 GGWRNDPELFEMVFPMDMRPQGHDIIRTWLFSTIVRAHHEHGTVPWWNATLNGWILDPDRKKMSKSKGNVVTPVDLLE-- 613
Cdd:PTZ00419 524 LGWPDQTDDLQRFFPTSLLETGSDILFFWVARMVMMSLHLTDKLPFKTVFLHAMVRDSQGEKMSKSKGNVIDPLEVIEgi 603
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502481621 614 -----------------------------------EHGSDAVRY-WAASARQGVDTAFDAQQMKVGRRLAIKLLNASKFA 657
Cdd:PTZ00419 604 slqdlnqklyegnlpekeikraielqkkefpngipECGTDALRFgLLAYTQQGRNINLDINRVVGYRHFCNKLWNAVKFA 683
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502481621 658 LGFGEvDGAEHPEQLLAQVTEP-----VDQSLLLELARVVEQATAGFEAWDYTkalEVTEAF--FW--SFCDDYLELVKA 728
Cdd:PTZ00419 684 LMKLL-KDFNLPNSTLFKPNNVeslpwEDKWILHRLNVAIKEVTEGFKEYDFS---EATQATynFWlyELCDVYLELIKP 759
|
810 820 830 840
....*....|....*....|....*....|....*....|....
gi 502481621 729 RAyggDEVEASAATTSARAALRVALDVQLRLLAPFIPFATEEVW 772
Cdd:PTZ00419 760 RL---SKQSDGERKQHAQDVLHTVLDIGLRLLHPMMPFITEELY 800
|
|
| IleS |
COG0060 |
Isoleucyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Isoleucyl-tRNA ... |
14-819 |
8.63e-63 |
|
Isoleucyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Isoleucyl-tRNA synthetase is part of the Pathway/BioSystem: Aminoacyl-tRNA synthetases
Pssm-ID: 439830 [Multi-domain] Cd Length: 931 Bit Score: 228.81 E-value: 8.63e-63
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502481621 14 PEKPSVDGLEDRWTGVWQEQDTYAfdRARAASLPREQLFTIDTPPpTASGSLHVGHVFGYTQADCMARYKRMTGAEVFYP 93
Cdd:COG0060 13 PMRANLPKREPEILKFWEENDIYE--KSREARAGRPKFVLHDGPP-YANGDIHIGHALNKILKDIIVRYKTMRGFDVPYV 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502481621 94 IGWDDNGLPTERRVQNYYGVRGDitqpyvegyeppqrggDGKStkaadqqpVSRPNFIELCHELTVEDEKAFEALFRRLG 173
Cdd:COG0060 90 PGWDCHGLPIELKVEKELGIKKK----------------DIEK--------VGIAEFREKCREYALKYVDEQREDFKRLG 145
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502481621 174 LSLDWNYQYRTIDDNARATSQQAFLRNLQRGEAYSAEAPGLWDVTFQTAVAQAELEARDY--PGAYHRIAFHGPQGDVEV 251
Cdd:COG0060 146 VWGDWDNPYLTMDPEYEESIWWALKKLYEKGLLYKGLKPVPWCPRCGTALAEAEVEYKDVtsPSIYVKFPVKDEKALLLL 225
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502481621 252 E-------TTRPELLPACVALIAHPD----------DERY---------------------------QDLFGSTVRTPLF 287
Cdd:COG0060 226 EdaylviwTTTPWTLPANLAVAVHPDidyvlvevtgGERLilaealveavlkelgiedyevlatfkgAELEGLRYEHPFY 305
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502481621 288 GVEVPVIAHP--AAE---MDKGAGI---AMccTFG-DltDVTWWRELQLPTRSVITRNGRLTGETPAWladgpgaqlyae 358
Cdd:COG0060 306 YVVGYDRAHPviLGDyvtTEDGTGIvhtAP--GHGeD--DFEVGKKYGLPVLNPVDDDGRFTEEAPLF------------ 369
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502481621 359 qlATKTVHTARENTVTALRESGELVGEpEKTQ-------RKanffekgDKPLeI--VTSrQWYIRNGG-RDAELnrALIE 428
Cdd:COG0060 370 --AGLFVKDANPAIIEDLKERGALLAR-EKIThsyphcwRC-------KTPL-IyrATP-QWFISMDKlRDRAL--EAIE 435
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502481621 429 rgaEVDFHPAYMERRHANWIEGlNGDWLVSRQRFFGVPFPIWYPlDADGEPdHENPITP-----------AEADLPVD-- 495
Cdd:COG0060 436 ---KVNWIPEWGEGRFGNMLEN-RPDWCISRQRYWGVPIPIWVC-EDCGEL-HRTEEVIgsvaelleeegADAWFELDlh 509
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502481621 496 ----PQTDTAPgfeesqrDQPGGFAADPDVLDTWATSSLSPQiiGGWRNDPELFemvFPMDMRPQGHDIIRTW-----LF 566
Cdd:COG0060 510 rpflDETLKCP-------KCGGTMRRVPDVLDVWFDSGSMHF--AVLENREELH---FPADFYLEGSDQTRGWfysslLT 577
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502481621 567 STIVRahhehGTVPWWNATLNGWILDPDRKKMSKSKGNVVTPVDLLEEHGSDAVRYWAASARQGVDTAFDAQQMKVGRRL 646
Cdd:COG0060 578 STALF-----GRAPYKNVLTHGFVLDEDGRKMSKSLGNVVDPQEVIDKYGADILRLWVASSDYWGDLRFSDEILKEVRDV 652
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502481621 647 AIKLLNASKFAL----GFgevDGAEH---PEQLLaqvtePVDQSLLLELARVVEQATAGFEAWDYTKAlevTEAFFwSFC 719
Cdd:COG0060 653 YRRLRNTYRFLLanldDF---DPAEDavpYEDLP-----ELDRWILSRLNELIKEVTEAYDNYDFHRA---YRALH-NFC 720
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502481621 720 DD-----YLELVKARAYGGDEVEASaattsaraalRVA--------LDVQLRLLAPFIPFATEEVWS---WWHSGSVHRA 783
Cdd:COG0060 721 VEdlsnwYLDISKDRLYTEAADSLD----------RRAaqttlyevLETLVRLLAPILPFTAEEIWQnlpGEAEESVHLA 790
|
890 900 910
....*....|....*....|....*....|....*....
gi 502481621 784 AWPTADEVR--PANLADVNVA-GVKPAAAAVLAGIRKAK 819
Cdd:COG0060 791 DWPEVDEELidEELEAKWDLVrEVRSAVLKALEAARKEK 829
|
|
| PLN02381 |
PLN02381 |
valyl-tRNA synthetase |
11-772 |
1.85e-59 |
|
valyl-tRNA synthetase
Pssm-ID: 215214 [Multi-domain] Cd Length: 1066 Bit Score: 220.16 E-value: 1.85e-59
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502481621 11 AQLPEKPSVDGLEDRWTGVWQEQDTYAFDrARAASLPreqlFTIDTPPPTASGSLHVGHVFGYTQADCMARYKRMTGAEV 90
Cdd:PLN02381 94 SQMAKQYSPSAVEKSWYAWWEKSGYFGAD-AKSSKPP----FVIVLPPPNVTGALHIGHALTAAIEDTIIRWKRMSGYNA 168
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502481621 91 FYPIGWDDNGLPTerrvqnyygvrgditQPYVEGYEPPQRGgdgkstkaADQQPVSRPNFIELCHELTVEDEKAFEALFR 170
Cdd:PLN02381 169 LWVPGVDHAGIAT---------------QVVVEKKLMRERH--------LTRHDIGREEFVSEVWKWKDEYGGTILNQLR 225
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502481621 171 RLGLSLDWNYQYRTIDDNARATSQQAFLRNLQRGEAYSAEAPGLWDVTFQTAVAQAELEARD--------YPGAYHRIAF 242
Cdd:PLN02381 226 RLGASLDWSRECFTMDEQRSKAVTEAFVRLYKEGLIYRDIRLVNWDCTLRTAISDVEVDYIDikertllkVPGYDKPVEF 305
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502481621 243 ----------HGPQGDVEVETTRPELLPACVALIAHPDDERYQDLFGSTVRTPLFGVEVPVIAHpAAEMDK--GAGIAMC 310
Cdd:PLN02381 306 gvltsfayplEGGLGEIVVATTRIETMLGDTAIAIHPDDERYKHLHGKFAVHPFNGRKLPIICD-AILVDPnfGTGAVKI 384
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502481621 311 CTFGDLTDVTWWRELQLPTRSVITRNGRLTGETPAWLADGPGaqlyaeqlatktvHTARENTVTALRESGeLVGEPEKTQ 390
Cdd:PLN02381 385 TPAHDPNDFEVGKRHNLEFINIFTDDGKINSNGGSEFAGMPR-------------FAAREAVIEALQKKG-LYRGAKNNE 450
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502481621 391 RKANFFEKGDKPLEIVTSRQWYIR-NGGRDAELNRALIERGAEVDFHPAYMERRHANWIEGLNgDWLVSRQRFFGVPFPI 469
Cdd:PLN02381 451 MRLGLCSRTNDVVEPMIKPQWFVNcSSMAKQALDAAIDGENKKLEFIPKQYLAEWKRWLENIR-DWCISRQLWWGHRIPA 529
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502481621 470 WYpldADGEPDHENPITPAEADLPVDPQTDTApgFEESQRDQPGG---FAADPDVLDTWATSSLSPQIIGGWRNDPELFE 546
Cdd:PLN02381 530 WY---VTLEDDQLKELGSYNDHWVVARNESDA--LLEASQKFPGKkfeLSQDPDVLDTWFSSGLFPLSVLGWPDDTDDLK 604
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502481621 547 MVFPMDMRPQGHDIIRTWLFSTIVRAHHEHGTVPWWNATLNGWILDPDRKKMSKSKGNVVTPVDLLE------------- 613
Cdd:PLN02381 605 AFYPTSVLETGHDILFFWVARMVMMGMQLGGDVPFRKVYLHPMIRDAHGRKMSKSLGNVIDPLEVINgisleglhkrlee 684
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502481621 614 ------------------------EHGSDAVRYWAAS-ARQGVDTAFDAQQMKVGRRLAIKLLNASKFALG-FGevDGAE 667
Cdd:PLN02381 685 gnldpkelvvakegqkkdfpngiaECGTDALRFALVSyTAQSDKINLDILRVVGYRQWCNKLWNAVRFAMSkLG--DDYT 762
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502481621 668 HPEQLLAQVTEPVDQSLLLELARVVEQATAGFEAWDYTKALEVTEAFF-WSFCDDYLELVKARaYGGDEVEASAATTSAR 746
Cdd:PLN02381 763 PPATLSVETMPFSCKWILSVLNKAISKTVSSLDAYEFSDAASTVYSWWqYQFCDVFIEAIKPY-FAGDNPEFASERAAAQ 841
|
810 820
....*....|....*....|....*.
gi 502481621 747 AALRVALDVQLRLLAPFIPFATEEVW 772
Cdd:PLN02381 842 DTLWICLDTGLRLLHPFMPFVTEELW 867
|
|
| Ile_Leu_Val_MetRS_core |
cd00668 |
catalytic core domain of isoleucyl, leucyl, valyl and methioninyl tRNA synthetases; Catalytic ... |
52-635 |
1.00e-48 |
|
catalytic core domain of isoleucyl, leucyl, valyl and methioninyl tRNA synthetases; Catalytic core domain of isoleucyl, leucyl, valyl and methioninyl tRNA synthetases. These class I enzymes are all monomers. However, in some species, MetRS functions as a homodimer, as a result of an additional C-terminal domain. These enzymes aminoacylate the 2'-OH of the nucleotide at the 3' of the appropriate tRNA. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains the characteristic class I HIGH and KMSKS motifs, which are involved in ATP binding. Enzymes in this subfamily share an insertion in the core domain, which is subject to both deletions and rearrangements. This editing region hydrolyzes mischarged cognate tRNAs and thus prevents the incorporation of chemically similar amino acids. MetRS has a significantly shorter insertion, which lacks the editing function.
Pssm-ID: 185674 [Multi-domain] Cd Length: 312 Bit Score: 175.30 E-value: 1.00e-48
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502481621 52 FTIDTPPPTASGSLHVGHVFGYTQADCMARYKRMTGAEVFYPIGWDDNGLPTERRVQnyygvrgditqpyvegyeppQRG 131
Cdd:cd00668 2 FYVTTPPPYANGSLHLGHALTHIIADFIARYKRMRGYEVPFLPGWDTHGLPIELKAE--------------------RKG 61
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502481621 132 GDGKSTkaadqqpVSRPNFIELCHELTVEDEKAFEALFRRLGLSLDWNYQYRTIDDNARATSQQAFLRNLQRGEAYSAEa 211
Cdd:cd00668 62 GRKKKT-------IWIEEFREDPKEFVEEMSGEHKEDFRRLGISYDWSDEYITTEPEYSKAVELIFSRLYEKGLIYRGT- 133
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502481621 212 pglwdvtfqtavaqaeleardypgayhriafhgpqgdvevettrpellpacvaliahpdderyqdlfgstvrtplfgveV 291
Cdd:cd00668 134 -------------------------------------------------------------------------------H 134
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502481621 292 PVIAHPaaemdkgagiamcctfgdltdvtwwrelqlptrsvitrngrltgetpawladgpgaqlyaeqlatktvhtaren 371
Cdd:cd00668 135 PVRITE-------------------------------------------------------------------------- 140
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502481621 372 tvtalresgelvgepektqrkanffekgdkpleivtsrQWYIRNGGRDAELNRAlIERGaevDFHPAYMERRHANWIEGL 451
Cdd:cd00668 141 --------------------------------------QWFFDMPKFKEKLLKA-LRRG---KIVPEHVKNRMEAWLESL 178
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502481621 452 nGDWLVSRQRFFGVPFPiwypldadgepdhenpitpaeadlpvdpqtdtapgfeesqrdqpggfaadPDVLDTWATSSLS 531
Cdd:cd00668 179 -LDWAISRQRYWGTPLP--------------------------------------------------EDVFDVWFDSGIG 207
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502481621 532 PQIIGGWRNDPELFEMVFPMDMRPQGHDIIRTWLFSTIVRAHHEHGTVPWWNATLNGWILDPDRKKMSKSKGNVVTPVDL 611
Cdd:cd00668 208 PLGSLGYPEEKEWFKDSYPADWHLIGKDILRGWANFWITMLVALFGEIPPKNLLVHGFVLDEGGQKMSKSKGNVIDPSDV 287
|
570 580
....*....|....*....|....*
gi 502481621 612 LEEHGSDAVRYWAAS-ARQGVDTAF 635
Cdd:cd00668 288 VEKYGADALRYYLTSlAPYGDDIRL 312
|
|
| Anticodon_Ia_Val |
cd07962 |
Anticodon-binding domain of valyl tRNA synthetases; This domain is found in valyl tRNA ... |
635-774 |
1.18e-37 |
|
Anticodon-binding domain of valyl tRNA synthetases; This domain is found in valyl tRNA synthetases (ValRS), which belong to the class Ia aminoacyl tRNA synthetases. It lies C-terminal to the catalytic core domain, and recognizes and specifically binds to the tRNA anticodon. ValRS catalyzes the transfer of valine to the 3'-end of its tRNA.
Pssm-ID: 153416 [Multi-domain] Cd Length: 135 Bit Score: 137.30 E-value: 1.18e-37
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502481621 635 FDAQQMKVGRRLAIKLLNASKFALGFGEvdgAEHPEQLLAQVTEPVDQSLLLELARVVEQATAGFEAWDYTKALEVTEAF 714
Cdd:cd07962 1 FDEKRVEGGRNFCNKLWNAARFVLMNLE---DDDEPEEDPESLSLADRWILSRLNKTVEEVTEALENYRFSEAATALYEF 77
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 502481621 715 FWS-FCDDYLELVKARAYGGDEVEASAATTSaraaLRVALDVQLRLLAPFIPFATEEVWSW 774
Cdd:cd07962 78 FWNdFCDWYLELVKPRLYGEDEEEKKAARAT----LYYVLETILRLLHPFMPFITEELWQR 134
|
|
| IleRS_core |
cd00818 |
catalytic core domain of isoleucyl-tRNA synthetases; Isoleucine amino-acyl tRNA synthetases ... |
58-635 |
5.23e-35 |
|
catalytic core domain of isoleucyl-tRNA synthetases; Isoleucine amino-acyl tRNA synthetases (IleRS) catalytic core domain . This class I enzyme is a monomer which aminoacylates the 2'-OH of the nucleotide at the 3' of the appropriate tRNA. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains the characteristic class I HIGH and KMSKS motifs, which are involved in ATP binding. IleRS has an insertion in the core domain, which is subject to both deletions and rearrangements. This editing region hydrolyzes mischarged cognate tRNAs and thus prevents the incorporation of chemically similar amino acids.
Pssm-ID: 173909 [Multi-domain] Cd Length: 338 Bit Score: 136.59 E-value: 5.23e-35
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502481621 58 PPTASGSLHVGHVFGYTQADCMARYKRMTGAEVFYPIGWDDNGLPTERRVQNYYGVRGDitqpyvegyeppqrggdgkst 137
Cdd:cd00818 9 PPYANGLPHYGHALNKILKDIINRYKTMQGYYVPRRPGWDCHGLPIELKVEKELGISGK--------------------- 67
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502481621 138 kaADQQPVSRPNFIELCHELTVEDEKAFEALFRRLGLSLDWNYQYRTIDDNARATSQQAFLRNLQRGEAYsaeapglwdv 217
Cdd:cd00818 68 --KDIEKMGIAEFNAKCREFALRYVDEQEEQFQRLGVWVDWENPYKTMDPEYMESVWWVFKQLHEKGLLY---------- 135
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502481621 218 tfqtavaqaeleaRDYpgayhriafhgpqgdvevettRPellpacvaliahpdderyqdlfgstvrtplfgvevpviahp 297
Cdd:cd00818 136 -------------RGY---------------------KV----------------------------------------- 140
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502481621 298 aaemdkgagiamcctfgdltdVTWwrelqlptrsvitrngrltgetpawladgpgaqlyaeqlatktvhtarentvtalr 377
Cdd:cd00818 141 ---------------------VPW-------------------------------------------------------- 143
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502481621 378 esgelvgepektqrkanffekgdkPLEIVTSRQWYIRNggrdAELNRALIERGAEVDFHPAYMERRHANWIEGLNgDWLV 457
Cdd:cd00818 144 ------------------------PLIYRATPQWFIRV----TKIKDRLLEANDKVNWIPEWVKNRFGNWLENRR-DWCI 194
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502481621 458 SRQRFFGVPFPIWYPLDADGEPDHEnpitpaeadlpvdpqtdtapgfeesqrdqpggfaaDPDVLDTWATSSLSPQIIGG 537
Cdd:cd00818 195 SRQRYWGTPIPVWYCEDCGEVLVRR-----------------------------------VPDVLDVWFDSGSMPYAQLH 239
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502481621 538 WRNDPELFEMVFPMDMRPQGHDIIRTWLFSTIVRAHHEHGTVPWWNATLNGWILDPDRKKMSKSKGNVVTPVDLLEEHGS 617
Cdd:cd00818 240 YPFENEDFEELFPADFILEGSDQTRGWFYSLLLLSTALFGKAPYKNVIVHGFVLDEDGRKMSKSLGNYVDPQEVVDKYGA 319
|
570
....*....|....*....
gi 502481621 618 DAVRYW-AASARQGVDTAF 635
Cdd:cd00818 320 DALRLWvASSDVYAEDLRF 338
|
|
| PLN02843 |
PLN02843 |
isoleucyl-tRNA synthetase |
30-790 |
1.06e-33 |
|
isoleucyl-tRNA synthetase
Pssm-ID: 215452 [Multi-domain] Cd Length: 974 Bit Score: 139.91 E-value: 1.06e-33
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502481621 30 WQEQDTYAFDRARAASLPreqlFTIDTPPPTASGSLHVGHVFGYTQADCMARYKRMTGAEVFYPIGWDDNGLPTERRV-Q 108
Cdd:PLN02843 16 WEENQVYKRVSDRNNGES----FTLHDGPPYANGDLHIGHALNKILKDFINRYQLLQGKKVHYVPGWDCHGLPIELKVlQ 91
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502481621 109 NY-YGVRGDITQPYVEgyeppqrggdgksTKAAdqqpvsrpnfielchELTVEDEKAFEALFRRLGLSLDWNYQYRTIDD 187
Cdd:PLN02843 92 SLdQEARKELTPIKLR-------------AKAA---------------KFAKKTVDTQRESFKRYGVWGDWENPYLTLDP 143
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502481621 188 NARATSQQAFLRNLQRGEAYSAEAPGLWDVTFQTAVAQAELEardYPG--------AYHRIAFHGPQGDVEVE------- 252
Cdd:PLN02843 144 EYEAAQIEVFGQMFLNGYIYRGRKPVHWSPSSRTALAEAELE---YPEghvsksiyVAFPVVSPSETSPEELEeflpgls 220
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502481621 253 ----TTRPELLPACVALIAHPD-----------DERYQDLFGSTVRTPLFGVEVPVIAH--------PAAEMDKGAGIAM 309
Cdd:PLN02843 221 laiwTTTPWTMPANAAVAVNDKlqysvvevqsfSEDESTSGGNKKKRPGNVLKEQQKLFlivatdlvPALEAKWGVKLVV 300
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502481621 310 CCTF--GDLTDVTWWRELQLPTRSVITRNGRLTGETPAWL---ADGPGAQLY-----------------------AEQLA 361
Cdd:PLN02843 301 LKTFpgSDLEGCRYIHPLYNRESPVVIGGDYITTESGTGLvhtAPGHGQEDYitglkyglpllspvddagkfteeAGQFS 380
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502481621 362 TKTVHTA-RENTVTALRESGELVGEpEKTQRKANFFEKGDKPLEIVTSRQWYIR-NGGRDAELnrALIERgaeVDFHPAY 439
Cdd:PLN02843 381 GLSVLGEgNAAVVEALDEAGSLLME-EAYGHKYPYDWRTKKPTIFRATEQWFASvEGFRQAAL--DAIDK---VKWIPAQ 454
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502481621 440 MERRHANWIEGlNGDWLVSRQRFFGVPFPIWYPLDADgEP-------DHENPI-----TPAEADLPVDpqtDTAPgfeES 507
Cdd:PLN02843 455 GENRIRAMVSG-RSDWCISRQRTWGVPIPVFYHVETK-EPlmneetiAHVKSIvaqkgSDAWWYMDVE---DLLP---EK 526
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502481621 508 QRDQPGGFAADPDVLDTWATSSLSPQIIGGWRNDPElfemvFPMDMRPQGHDIIRTWLFSTIVRAHHEHGTVPWWNATLN 587
Cdd:PLN02843 527 YRDKASDYEKGTDTMDVWFDSGSSWAGVLGSREGLS-----YPADLYLEGSDQHRGWFQSSLLTSVATKGKAPYKSVLTH 601
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502481621 588 GWILDPDRKKMSKSKGNVVTPVDLLE---------EHGSDAVRYWAASARQGVDTAFDAQQMKVGRRLAIKLLNASKFAL 658
Cdd:PLN02843 602 GFVLDEKGFKMSKSLGNVVDPRLVIEggknqkqepAYGADVLRLWVASVDYTGDVLIGPQILKQMSDIYRKLRGTLRYLL 681
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502481621 659 G----FGEVDGAEHpEQLLAqvtepVDQSLLLELARVVEQATAGFEAWDYTKALEVTEAF-FWSFCDDYLELVKARAY-G 732
Cdd:PLN02843 682 GnlhdWKPDNAVPY-EDLPS-----IDKYALFQLENVVNEIEESYDNYQFFKIFQILQRFtIVDLSNFYLDVAKDRLYvG 755
|
810 820 830 840 850 860
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 502481621 733 GDEveaSAATTSARAALRVALDVQLRLLAPFIPFATEEVWSWW-------HSGSVHRAAWPTADE 790
Cdd:PLN02843 756 GTT---SFTRRSCQTVLAAHLLSLLRAIAPILPHLAEDAWQNLpfqedgsAAESVFEAGWPTPNE 817
|
|
| LeuS |
COG0495 |
Leucyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Leucyl-tRNA ... |
23-790 |
1.11e-30 |
|
Leucyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Leucyl-tRNA synthetase is part of the Pathway/BioSystem: Aminoacyl-tRNA synthetases
Pssm-ID: 440261 [Multi-domain] Cd Length: 826 Bit Score: 129.79 E-value: 1.11e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502481621 23 EDRWTGVWQEQDTYAFDRARaaslPREQLFTIDT-PPPtaSGSLHVGHVFGYTQADCMARYKRMTGAEVFYPIGWDDNGL 101
Cdd:COG0495 11 EKKWQKYWEENGTFKADEDS----SKPKYYVLDMfPYP--SGRLHMGHVRNYTIGDVVARYKRMQGYNVLHPMGWDAFGL 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502481621 102 PTErrvqNY---YGVrgditqpyvegyePPqrggdGKSTKAadqqpvsrpNfIElcheltvedekAFEALFRRLGLSLDW 178
Cdd:COG0495 85 PAE----NAaikNGV-------------HP-----AEWTYE---------N-IA-----------NMRRQLKRLGLSYDW 121
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502481621 179 NyqyRTIddnarATS--------QQAFLRNLQRGEAYSAEAPGLWDVTFQTAVA--Q----------AELEAR------- 231
Cdd:COG0495 122 S---REI-----ATCdpeyykwtQWIFLQLYEKGLAYRKEAPVNWCPVDQTVLAneQvidgrcwrcgAPVEKKelpqwfl 193
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502481621 232 ---DY--------------P---------------GAyhRIAF--HGPQGDVEVETTRPELLPAC-----------VALI 266
Cdd:COG0495 194 kitDYadellddldkldgwPekvktmqrnwigrseGA--EVDFpvEGSDEKITVFTTRPDTLFGAtfmvlapehplVKEL 271
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502481621 267 AHPDD----ERYQD-------------------LF-GSTVRTPLFGVEVPVIahpAAE---MDKGAGIAMCCTFGDLTDv 319
Cdd:COG0495 272 ATPEQnaavAAFIEeakkkseiertsetkektgVFtGLYAINPLTGEKIPIW---IADyvlMDYGTGAVMAVPAHDQRD- 347
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502481621 320 twW---RELQLPTRSVITRNGRLTGETP--AWLADGPgaqLY-AEQLATKTVHTARENTVTALRESGelVGEpektqRKA 393
Cdd:COG0495 348 --FefaKKYGLPIKQVIAPEDGDDPDILeeAYTGDGV---LInSGEFDGLDSEEAKEAIIEWLEEKG--LGK-----RKV 415
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502481621 394 NFfekgdkpleivtsRqwyIRnggrdaelnraliergaevdfhpaymerrhanwieglngDWLVSRQRFFGVPFPIWYpl 473
Cdd:COG0495 416 NY-------------R---LR---------------------------------------DWLISRQRYWGEPIPIIH-- 438
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502481621 474 DADGEpdhenpITP-AEADLPV--------DPQT----DTAPGFEESQRDQPGGfAA--DPDVLDTWATSS------LSP 532
Cdd:COG0495 439 CEDCG------VVPvPEDQLPVelpedvdfDPTGgsplARAPEWVNVTCPKCGG-PArrETDTMDTFVDSSwyylryTDP 511
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502481621 533 qiiggwRN-----DPELFEMVFPMD----------------------MRPQGHDIIR---TWLFStivrahheHGTVPww 582
Cdd:COG0495 512 ------HNdeapfDPEAANYWLPVDqyiggiehailhllyarfftkvLRDLGLVSFDepfKRLLT--------QGMVL-- 575
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502481621 583 NATLNGWILDPdRKKMSKSKGNVVTPVDLLEEHGSDAVR-Y------------WAASarqGVDTAFdaqqmkvgR----- 644
Cdd:COG0495 576 EVGKDGVVIGG-IEKMSKSKGNVVDPDEIIEKYGADTLRlFemfagpperdleWSDS---GVEGAY--------Rflnrv 643
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502481621 645 -RLAIkllnaskfalgfgevdgaEHPEQLLAQVTE--PVDQSLLLELARVVEQATAGFEAWDYTKAL----EVTEAffws 717
Cdd:COG0495 644 wRLVV------------------DEAEALKLDVADlsEADKELRRALHKTIKKVTEDIERLRFNTAIaalmELVNA---- 701
|
890 900 910 920 930 940 950
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 502481621 718 fcddyleLVKARAYGGDEveasaattsaRAALRVALDVQLRLLAPFIPFATEEVWSWW-HSGSVHRAAWPTADE 790
Cdd:COG0495 702 -------LYKAKDSGEAD----------RAVLREALETLVLLLAPFAPHIAEELWERLgHEGSVADAPWPEADE 758
|
|
| PLN02563 |
PLN02563 |
aminoacyl-tRNA ligase |
3-790 |
4.60e-28 |
|
aminoacyl-tRNA ligase
Pssm-ID: 178177 [Multi-domain] Cd Length: 963 Bit Score: 121.85 E-value: 4.60e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502481621 3 DSTAGTRPAQLPEKPSVDGLEDRWTGVWQEQDTYAFDRARAASLPReqLFTIDT-PPPTASGsLHVGHVFGYTQADCMAR 81
Cdd:PLN02563 66 TSTTAKTTPAAKRAYPFHEIEPKWQRYWEENRTFRTPDDVDTSKPK--FYVLDMfPYPSGAG-LHVGHPEGYTATDILAR 142
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502481621 82 YKRMTGAEVFYPIGWDDNGLPTERrvqnyYGVrgditqpyvegyeppQRGGDGKSTkaadqqpvsrpnfielchelTVED 161
Cdd:PLN02563 143 YKRMQGYNVLHPMGWDAFGLPAEQ-----YAI---------------ETGTHPKIT--------------------TLKN 182
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502481621 162 EKAFEALFRRLGLSLDWNYQYRTIDDNARATSQQAFLRNLQRGEAYSAEAPGLWDVTFQTAVAQAE-------------- 227
Cdd:PLN02563 183 IARFRSQLKSLGFSYDWDREISTTEPEYYKWTQWIFLQLLKRGLAYQAEVPVNWCPALGTVLANEEvvdglsergghpvi 262
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502481621 228 ---------------------LEARDYP---------------GAyhRIAFHGPQGD-------VEVETTRPELLPACVA 264
Cdd:PLN02563 263 rkpmrqwmlkitayadrlledLDDLDWPesikemqrnwigrseGA--ELDFSVLDGEgkerdekITVYTTRPDTLFGATY 340
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502481621 265 LIAHPDDeryqdlfgstvrtPLfgveVPVIAHPAAEMDKGAGIAMCCTFGDLtDVTwwrELQLPTRSVIT----RNgRLT 340
Cdd:PLN02563 341 LVVAPEH-------------PL----LSSLTTAEQKEAVEEYVDAASRKSDL-ERT---ELQKEKTGVFTgsyaIN-PAT 398
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502481621 341 GET-PAWLADgpgaqlYaeqlatktvhtarentVTALRESGELVGEPEKTQRKANFFEKGDKPLEIVTSrqwyiRNGGRD 419
Cdd:PLN02563 399 GEAiPIWVAD------Y----------------VLGSYGTGAIMAVPAHDTRDFEFAQKFDLPIKWVVK-----PADGNE 451
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502481621 420 AELNRALIERGAEVD----------FHPAYMERRHANWIEGLNG----------DWLVSRQRFFGVPFPIWYPLDADgep 479
Cdd:PLN02563 452 DDAEKAYTGEGVIVNssssgldingLSSKEAAKKVIEWLEETGNgkkkvnyklrDWLFARQRYWGEPIPVVFLEDSG--- 528
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502481621 480 dheNPITPAEADLPVD-PQTDtapgfeesqRDQPGGFAADP-----------DVLD-TWA---TSSLsPQIIGG-W---- 538
Cdd:PLN02563 529 ---EPVPVPESDLPLTlPELD---------DFTPTGTGEPPlakavswvntvDPSSgKPArreTNTM-PQWAGScWyylr 595
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502481621 539 ----RNDPELFEMV-----FPMDMRPQG--HDII-----RTW---LFSTIVRAHHE------------------------ 575
Cdd:PLN02563 596 fmdpKNSNALVDKEkekywMPVDLYVGGaeHAVLhllyaRFWhkvLYDIGVVSTKEpfqclvnqgmilgeveytafkdsd 675
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502481621 576 ----------------HGTVPWWNATLNGWIL----DPDRK------KMSKSKGNVVTPVDLLEEHGSDAVRY------- 622
Cdd:PLN02563 676 geyvsadtadrlgelqQEKIPEEKVIKSGDSFvlkdDPSIRliarahKMSKSRGNVVNPDDVVSEYGADSLRLyemfmgp 755
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502481621 623 ------WAASARQGVdTAFdaqQMKVGRRLAIKLLNASKFALGFGEVDGAEHPEQLlaqvtepvdQSLLLELARVVEqat 696
Cdd:PLN02563 756 lrdsktWSTSGVEGV-HRF---LGRTWRLVVGAPLPDGSFRDGTVVTDEEPSLEQL---------RLLHKCIAKVTE--- 819
|
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502481621 697 agfeawdytkalEVTEAFFWSFCDDYLELVKArAYGGDEVEasaattsaraalRVALDVQLRLLAPFIPFATEEVWSWW- 775
Cdd:PLN02563 820 ------------EIESTRFNTAISAMMEFTNA-AYKWDKVP------------REAIEPFVLLLSPYAPHLAEELWFRLg 874
|
970
....*....|....*
gi 502481621 776 HSGSVHRAAWPTADE 790
Cdd:PLN02563 875 HSNSLAYEPWPEANP 889
|
|
| Anticodon_1 |
pfam08264 |
Anticodon-binding domain of tRNA ligase; This domain is found mainly hydrophobic tRNA ... |
681-833 |
3.02e-26 |
|
Anticodon-binding domain of tRNA ligase; This domain is found mainly hydrophobic tRNA synthetases. The domain binds to the anticodon of the tRNA ligase.
Pssm-ID: 400523 [Multi-domain] Cd Length: 141 Bit Score: 104.79 E-value: 3.02e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502481621 681 DQSLLLELARVVEQATAGFEAWDYTKALEVTEAFFWS-FCDDYLELVKARAYGGDEveasaaTTSARAALRVALDVQLRL 759
Cdd:pfam08264 1 DRWILSRLNKLIKEVTEAYENYRFNTAAQALYEFFWNdLSDWYLELIKDRLYGEEP------DSRAQTTLYEVLETLLRL 74
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 502481621 760 LAPFIPFATEEVwswWHSGSVHRAAWPTadevrPANLADVNVAGVKPAAAAVLAGIRKAKSEAKLGMRAQVTAM 833
Cdd:pfam08264 75 LAPFMPFITEEL---WQKESIHLAPWPE-----DAELEEAELEEAFELRQEIVQAIRKLRSELKIKKSLPLEVV 140
|
|
| leuS |
PRK12300 |
leucyl-tRNA synthetase; Reviewed |
65-790 |
1.12e-25 |
|
leucyl-tRNA synthetase; Reviewed
Pssm-ID: 237049 [Multi-domain] Cd Length: 897 Bit Score: 114.20 E-value: 1.12e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502481621 65 LHVGHVFGYTQADCMARYKRMTGAEVFYPIGWDDNGLP--------------TERRVQNYYGVRGDItqpyVEGYEPPQr 130
Cdd:PRK12300 1 LHVGHGRTYTIGDVIARYKRMRGYNVLFPMAFHVTGTPilgiaeriargdpeTIELYKSLYGIPEEE----LEKFKDPE- 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502481621 131 ggdgkstkaadqqpvsrpNFIELCHEltvEDEKAFealfRRLGLSLDWNYQYRTIDDNARATSQQAFLRNLQRGEAYSAE 210
Cdd:PRK12300 76 ------------------YIVEYFSE---EAKEDM----KRIGYSIDWRREFTTTDPEYSKFIEWQFRKLKEKGLIVKGS 130
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502481621 211 APGLWDVTFQTAVaqaeleardypGAyhriafHGPQGDVEVE--------------------TTRPELLPACVALIAHPD 270
Cdd:PRK12300 131 HPVRYCPNDNNPV-----------GD------HDLLDGEEPEiveytlikfeesedlilpaaTLRPETIFGVTNLWVNPD 193
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502481621 271 DE---------------------RYQD-------------LFGSTVRTPLFGVEVPVIahPAA--EMDKGAGIAMCCTFG 314
Cdd:PRK12300 194 ATyvkaevdgekwivskeaaeklSFQDrdveiieeikgseLIGKKVKNPVTGKEVPIL--PADfvDPDNGTGVVMSVPAH 271
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502481621 315 DLTDVTWWRELQLPTR--------SVITRNGrlTGETPAWLA---------DGPGA-----QLYAEQ------------L 360
Cdd:PRK12300 272 APYDYVALRDLKKNKElldviepiPLIEVEG--YGEFPAKEVveklgiksqEDPELeeatkEVYRAEfhkgvlkentgeY 349
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502481621 361 ATKTVHTARENTVTALRESGelVGEpektqrkaNFFEKGDKPleiVTSR------------QWYIRNGGRD-AELNRALI 427
Cdd:PRK12300 350 AGKPVREAREKITKDLIEKG--IAD--------IMYEFSNRP---VYCRcgtecvvkvvkdQWFIDYSDPEwKELAHKAL 416
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502481621 428 ERgaeVDFHPAYMERRHANWIEGLNgDWLVSRQRFFGVPFPiWypldadgepDHENPItpaeadlpvdpqtdtapgfeES 507
Cdd:PRK12300 417 DN---MEIIPEEYRKEFENTIDWLK-DRACARRRGLGTRLP-W---------DEEWII--------------------ES 462
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502481621 508 QRD--------------QPGGFAAD---PDVLDT-----------WATSSLSPQIIGGWRNDpelFEMVFPMDMRPQGHD 559
Cdd:PRK12300 463 LSDstiymayytiahkiREYGIKPEqltPEFFDYvflgkgdpeevSKKTGIPKEILEEMREE---FLYWYPVDWRHSGKD 539
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502481621 560 IIRTWLfsTIVRAHH------EH---GTVpwwnatLNGWILdPDRKKMSKSKGNVVTPVDLLEEHGSDAVR-YWAASARQ 629
Cdd:PRK12300 540 LIPNHL--TFFIFNHvaifpeEKwprGIV------VNGFVL-LEGKKMSKSKGNVIPLRKAIEEYGADVVRlYLTSSAEL 610
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502481621 630 GVDTAFDAQQMK-VGRRLaIKLLNaskFALGFGEVDGAEHPeqllaqvtEPVDQSLLLELARVVEQATAGFEAWDYTKAl 708
Cdd:PRK12300 611 LQDADWREKEVEsVRRQL-ERFYE---LAKELIEIGGEEEL--------RFIDKWLLSRLNRIIKETTEAMESFQTRDA- 677
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502481621 709 eVTEAFF--WSFCDDYLELVkaraygGDEVeasaattsaRAALRVALDVQLRLLAPFIPFATEEVWSWW-HSGSVHRAAW 785
Cdd:PRK12300 678 -VQEAFYelLNDLRWYLRRV------GEAN---------NKVLREVLEIWIRLLAPFTPHLAEELWHKLgGEGFVSLEKW 741
|
....*
gi 502481621 786 PTADE 790
Cdd:PRK12300 742 PEPDE 746
|
|
| PLN02882 |
PLN02882 |
aminoacyl-tRNA ligase |
30-621 |
6.37e-22 |
|
aminoacyl-tRNA ligase
Pssm-ID: 215477 [Multi-domain] Cd Length: 1159 Bit Score: 102.11 E-value: 6.37e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502481621 30 WQEQDTYAFDRARAASLPReqlFTIDTPPPTASGSLHVGHVFGYTQADCMARYKRMTGAEVFYPIGWDDNGLPTERRVQN 109
Cdd:PLN02882 21 WSEIDAFKTQLKRTEGLPE---YIFYDGPPFATGLPHYGHILAGTIKDIVTRYQSMTGHHVTRRFGWDCHGLPVEYEIDK 97
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502481621 110 YYGV--RGDITQPYVEGYEppqrggdgkstkaadqqpvsrpnfiELCHELTVEDEKAFEALFRRLGLSLDWNYQYRTIDD 187
Cdd:PLN02882 98 KLGIkrRDDVLKMGIDKYN-------------------------EECRSIVTRYSKEWEKTVTRTGRWIDFENDYKTMDP 152
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502481621 188 NARATSQQAFLRNLQRGEAYSaeapGLWDVTFQTAVA------QAELEARDYPGAYHRIAF---HGPQGDVEVE-TTRPE 257
Cdd:PLN02882 153 KFMESVWWVFKQLFEKGLVYK----GFKVMPYSTACKtplsnfEAGLNYKDVSDPAVMVSFpivGDPDNASFVAwTTTPW 228
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502481621 258 LLPACVALIAHPD------------------DERYQDLFGSTVR------------------------------TPLFG- 288
Cdd:PLN02882 229 TLPSNLALCVNPNftyvkvrnkytgkvyivaESRLSALPTAKPKskkgskpenaaegyevlakvpgsslvgkkyEPLFDy 308
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502481621 289 ------VEVPVIAHPAAEMDKGAGIAMCC-TFGD------LTDVTWWRELQLPTrsVITRNGRLTGETPawladgpgaql 355
Cdd:PLN02882 309 fsefsdTAFRVVADDYVTDDSGTGVVHCApAFGEddyrvcLANGIIEKGGNLPV--PVDDDGCFTEKVT----------- 375
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502481621 356 yaeQLATKTVHTARENTVTALRESGELVGEPEKTQRKAnFFEKGDKPL--EIVTSrqWYIRNggrdAELNRALIERGAEV 433
Cdd:PLN02882 376 ---DFSGRYVKDADKDIIAAIKAKGRLVKSGSITHSYP-FCWRSDTPLiyRAVPS--WFVKV----EEIKDRLLENNKQT 445
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502481621 434 DFHPAYM-ERRHANWIEGLNgDWLVSRQRFFGVPFPIWypLDADGEpdhENPITPAEADLP--------------VDPQT 498
Cdd:PLN02882 446 YWVPDYVkEKRFHNWLENAR-DWAVSRSRFWGTPLPIW--ISDDGE---EVVVIGSIAELEklsgvkvtdlhrhfIDHIT 519
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502481621 499 ---DTAPGFEESQRDQpggfaadpDVLDTWATSSLSP--QIIGGWRNDpELFEMVFPMDMRPQGHDIIRTWLFSTIVRAH 573
Cdd:PLN02882 520 ipsSRGPEFGVLRRVD--------DVFDCWFESGSMPyaYIHYPFENK-ELFEKNFPADFVAEGLDQTRGWFYTLMVLST 590
|
650 660 670 680
....*....|....*....|....*....|....*....|....*...
gi 502481621 574 HEHGTVPWWNATLNGWILDPDRKKMSKSKGNVVTPVDLLEEHGSDAVR 621
Cdd:PLN02882 591 ALFDKPAFKNLICNGLVLAEDGKKMSKSLKNYPDPNEVIDKYGADALR 638
|
|
| MetG |
COG0143 |
Methionyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Methionyl-tRNA ... |
52-773 |
2.60e-20 |
|
Methionyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Methionyl-tRNA synthetase is part of the Pathway/BioSystem: Aminoacyl-tRNA synthetases
Pssm-ID: 439913 [Multi-domain] Cd Length: 544 Bit Score: 95.57 E-value: 2.60e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502481621 52 FTIDTPPPTASGSLHVGHVFGYTQADCMARYKRMTGAEVFYPIGWDDNGLPTERRVQNyygvrgditqpyvEGYEPpqrg 131
Cdd:COG0143 3 FLVTTAIPYANGPPHIGHLYTYIPADILARYQRLRGHDVLFVTGTDEHGTKIELAAEK-------------EGITP---- 65
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502481621 132 gdgkstkaadqqpvsrpnfIELCheltveDE--KAFEALFRRLGLSLDwNYqYRTIDDNARATSQQAFLRNLQRGEAYSa 209
Cdd:COG0143 66 -------------------QELV------DRihAEFKELFEKLGISFD-NF-IRTTSPEHKELVQEIFQRLYDNGDIYK- 117
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502481621 210 eapglwdvtfqtavaqaeleaRDYPGAYhriafhgpqgDVEVETTrpelLPacvaliahpddERYQDlfgstvrtplfGv 289
Cdd:COG0143 118 ---------------------GEYEGWY----------CPECERF----LP-----------DRYVE-----------G- 139
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502481621 290 EVPVIAHPAAEMDKgagiamCCTFGDLTDVTwwrELQLPtRSVITrngrltGETPAWladgpgaqlyaeqlatktvhtar 369
Cdd:COG0143 140 TCPKCGAEDAYGDQ------CENCGATLEPT---ELINP-RSAIS------GAPPEL----------------------- 180
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502481621 370 entvtalRESgelvgepektqrkANFFEKGDK---PLeivtsRQWYIRNGgrdaelnraliergaevDFHPaymERRH-- 444
Cdd:COG0143 181 -------REE-------------EHYFFRLSKyqdRL-----LEWIEENP-----------------DIQP---EVRNev 215
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502481621 445 ANWIE-GLNgDWLVSRqRF-FGVPFPiwypldadGEPDHE---------NPITPAEadlpvdpqtdtapgfeesqrdqpg 513
Cdd:COG0143 216 LSWLKeGLQ-DLSISR-DFdWGIPVP--------GDPGKVfyvwfdaliGYISATK------------------------ 261
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502481621 514 GFAADPDVLDTWATsslspqiigGWRN-DPELFEMVfpmdmrpqGHDIIRtwlFSTIV-------------RAHHEHGtv 579
Cdd:COG0143 262 GYADDRGLPEDFEK---------YWPApDTELVHFI--------GKDIIR---FHAIIwpamlmaaglplpKKVFAHG-- 319
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502481621 580 pWWnaTLNGwildpdrKKMSKSKGNVVTPVDLLEEHGSDAVRYW-AASARQGVDTAFDAQQMKvgRR----LAIKLLN-A 653
Cdd:COG0143 320 -FL--TVEG-------EKMSKSRGNVIDPDDLLDRYGPDALRYYlLREVPFGQDGDFSWEDFV--ARvnsdLANDLGNlA 387
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502481621 654 SKfALGF------GEVdgaehPEqllAQVTEPVDQSLLLELARVVEQATAGFEAWDYTKALEVTEAfFWSFCDDYLE--- 724
Cdd:COG0143 388 SR-TLSMihkyfdGKV-----PE---PGELTEADEELLAEAEAALEEVAEAMEAFEFRKALEEIMA-LARAANKYIDeta 457
|
730 740 750 760 770 780
....*....|....*....|....*....|....*....|....*....|....*....|
gi 502481621 725 ---LVK----ARAyggDEVeasaattsaraaLRVALDVqLR----LLAPFIPFATEEVWS 773
Cdd:COG0143 458 pwkLAKdedpERL---ATV------------LYTLLEA-LRilaiLLKPFLPETAEKILE 501
|
|
| PTZ00427 |
PTZ00427 |
isoleucine-tRNA ligase, putative; Provisional |
15-623 |
2.15e-18 |
|
isoleucine-tRNA ligase, putative; Provisional
Pssm-ID: 173617 [Multi-domain] Cd Length: 1205 Bit Score: 90.80 E-value: 2.15e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502481621 15 EKPSVDGLEDRWTGVWQEQDtyAFDRARAASLPREQLFTIDTPPpTASGSLHVGHVFGYTQADCMARYKRMTGAEVFYPI 94
Cdd:PTZ00427 70 ENPNIVEEEEKVLKYWKSID--AFNTSNKLAKNKKAYIFYDGPP-FATGLPHYGHLLAGIIKDCVTRYFYQCGFSVERKF 146
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502481621 95 GWDDNGLPTERRVQ--NYYGVRGDITQPYVEGYEppqrggdgkstkaadqqpvsrpnfiELCHELTVEDEKAFEALFRRL 172
Cdd:PTZ00427 147 GWDCHGLPIEYEIEkeNNINKKEDILKMGIDVYN-------------------------EKCRGIVLKYSNEWVKTVERI 201
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502481621 173 GLSLDWNYQYRTIDDNARATSQQAFLRNLQRGEAYSAEAPGLWDVTFQTAVAQAELE-----------------ARDYP- 234
Cdd:PTZ00427 202 GRWIDFKNDYKTMDKTFMESVWWVFSELYKNNYVYKSFKVMPYSCKCNTPISNFELNlnykdtpdpsiiisfvlCSDFPk 281
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502481621 235 -------------------------------GAYHRIAFHGPQGDVEV--ETTRPELLPACVAL----------IAHPDD 271
Cdd:PTZ00427 282 veeecnieedkqllgekysvlynnkrensnnGNNNSTNNVCYAQHSEIlaWTTTPWTLPSNLALcvnehftylrIHHVKS 361
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502481621 272 ERY-------------------QDL------FGSTVR----TPLFGV----------EVPVIAHPAAEMDKGAGIAMCC- 311
Cdd:PTZ00427 362 NRVvivgecrlewimkelkwnvEDLkivnrfKGKELKglryKPLFTNfyekynfkerAYKILADDFVTDDAGTGIVHCAp 441
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502481621 312 TFG-DLTDVTWWRELQLPTRSV----ITRNGRLTGETpawladgpgaqlyaEQLATKTVHTARENTVTALRESGELVGEp 386
Cdd:PTZ00427 442 TYGeDDFRVCKKNGVIDPEKNIfidpLDANGYFTNEV--------------EEVQNLYIKEADNVIKKKLKNENRLLSN- 506
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502481621 387 EKTQRKANFFEKGDKPLEIVTSRQWYIRNGGRDAELnralIERGAEVDFHPAYM-ERRHANWIEGLNgDWLVSRQRFFGV 465
Cdd:PTZ00427 507 NTIVHSYPFCWRSDTPLIYRAIPAWFIRVSNSTNEL----VKNNETTYWIPAHIkEKKFHNWIKDAK-DWCISRNRYWGT 581
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502481621 466 PFPIWypldADGEPD-----------------------HENPITPAEADlpvDPQTDTAPGFEESqrdqpggfaadPDVL 522
Cdd:PTZ00427 582 PIPIW----ADEKMEtvicvesikhleelsgvknindlHRHFIDHIEIK---NPKGKTYPKLKRI-----------PEVF 643
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502481621 523 DTWATSSLSP--QIIGGWRNDPELFEMVFPMDMRPQGHDIIRTWLFSTIVRAHHEHGTVPWWNATLNGWILDPDRKKMSK 600
Cdd:PTZ00427 644 DCWFESGSMPyaKVHYPFSTEKEDFHKIFPADFIAEGLDQTRGWFYTLLVISTLLFDKAPFKNLICNGLVLASDGKKMSK 723
|
730 740
....*....|....*....|...
gi 502481621 601 SKGNVVTPVDLLEEHGSDAVRYW 623
Cdd:PTZ00427 724 RLKNYPDPLYILDKYGADSLRLY 746
|
|
| LeuRS_core |
cd00812 |
catalytic core domain of leucyl-tRNA synthetases; Leucyl tRNA synthetase (LeuRS) catalytic ... |
52-217 |
1.17e-15 |
|
catalytic core domain of leucyl-tRNA synthetases; Leucyl tRNA synthetase (LeuRS) catalytic core domain. This class I enzyme is a monomer which aminoacylates the 2'-OH of the nucleotide at the 3' of the appropriate tRNA. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains the characteristic class I HIGH and KMSKS motifs, which are involved in ATP binding. In Aquifex aeolicus, the gene encoding LeuRS is split in two, just before the KMSKS motif. Consequently, LeuRS is a heterodimer, which likely superimposes with the LeuRS monomer found in most other organisms. LeuRS has an insertion in the core domain, which is subject to both deletions and rearrangements and thus differs between prokaryotic LeuRS and archaeal/eukaryotic LeuRS. This editing region hydrolyzes mischarged cognate tRNAs and thus prevents the incorporation of chemically similar amino acids.
Pssm-ID: 173906 [Multi-domain] Cd Length: 314 Bit Score: 78.83 E-value: 1.17e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502481621 52 FTIDTPPPTASGSLHVGHVFGYTQADCMARYKRMTGAEVFYPIGWDDNGLPTE----RRVQNyygvrgditqpyvegyep 127
Cdd:cd00812 2 FYILVMFPYPSGALHVGHVRTYTIGDIIARYKRMQGYNVLFPMGFDAFGLPAEnaaiKIGRD------------------ 63
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502481621 128 PQrggdgKSTKAadqqpvsrpnFIelcheltvedeKAFEALFRRLGLSLDWNYQYRTID-DNARATsQQAFLRNLQRGEA 206
Cdd:cd00812 64 PE-----DWTEY----------NI-----------KKMKEQLKRMGFSYDWRREFTTCDpEYYKFT-QWLFLKLYEKGLA 116
|
170
....*....|.
gi 502481621 207 YSAEAPGLWDV 217
Cdd:cd00812 117 YKKEAPVNWCK 127
|
|
| LeuRS_core |
cd00812 |
catalytic core domain of leucyl-tRNA synthetases; Leucyl tRNA synthetase (LeuRS) catalytic ... |
409-627 |
1.65e-13 |
|
catalytic core domain of leucyl-tRNA synthetases; Leucyl tRNA synthetase (LeuRS) catalytic core domain. This class I enzyme is a monomer which aminoacylates the 2'-OH of the nucleotide at the 3' of the appropriate tRNA. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains the characteristic class I HIGH and KMSKS motifs, which are involved in ATP binding. In Aquifex aeolicus, the gene encoding LeuRS is split in two, just before the KMSKS motif. Consequently, LeuRS is a heterodimer, which likely superimposes with the LeuRS monomer found in most other organisms. LeuRS has an insertion in the core domain, which is subject to both deletions and rearrangements and thus differs between prokaryotic LeuRS and archaeal/eukaryotic LeuRS. This editing region hydrolyzes mischarged cognate tRNAs and thus prevents the incorporation of chemically similar amino acids.
Pssm-ID: 173906 [Multi-domain] Cd Length: 314 Bit Score: 72.28 E-value: 1.65e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502481621 409 RQWYIRNGgrDAELNRALIERGAEVDFHPAYMERRHANWIEglngdwlVSRQRFFGVPFPIwypldadgepdhenpitpa 488
Cdd:cd00812 130 DQWFLKYS--ETEWKEKLLKDLEKLDGWPEEVRAMQENWIG-------CSRQRYWGTPIPW------------------- 181
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502481621 489 eadlpvdpqTDTAPGFEESqrdqpggfaadpdvldTW-----ATSSLSPQ-IIGGWRNDPELFEMVFPMDMRPQGHD-II 561
Cdd:cd00812 182 ---------TDTMESLSDS----------------TWyyaryTDAHNLEQpYEGDLEFDREEFEYWYPVDIYIGGKEhAP 236
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 502481621 562 RTWLFStivRAHH-----EHGTVPWWNATL--NGWILDPDrKKMSKSKGNVVTPVDLLEEHGSDAVRYWAASA 627
Cdd:cd00812 237 NHLLYS---RFNHkalfdEGLVTDEPPKGLivQGMVLLEG-EKMSKSKGNVVTPDEAIKKYGADAARLYILFA 305
|
|
| MetRS_core |
cd00814 |
catalytic core domain of methioninyl-tRNA synthetases; Methionine tRNA synthetase (MetRS) ... |
54-217 |
2.48e-12 |
|
catalytic core domain of methioninyl-tRNA synthetases; Methionine tRNA synthetase (MetRS) catalytic core domain. This class I enzyme aminoacylates the 2'-OH of the nucleotide at the 3' of the appropriate tRNA. MetRS, which consists of the core domain and an anti-codon binding domain, functions as a monomer. However, in some species the anti-codon binding domain is followed by an EMAP domain. In this case, MetRS functions as a homodimer. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains the characteristic class I HIGH and KMSKS motifs, which are involved in ATP binding. As a result of a deletion event, MetRS has a significantly shorter core domain insertion than IleRS, ValRS, and LeuR. Consequently, the MetRS insertion lacks the editing function.
Pssm-ID: 173907 [Multi-domain] Cd Length: 319 Bit Score: 68.71 E-value: 2.48e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502481621 54 IDTPPPTASGSLHVGHVFGYTQADCMARYKRMTGAEVFYPIGWDDNGLPTERrvqnyygvrgditqpyvegyeppqrggd 133
Cdd:cd00814 4 ITTALPYVNGVPHLGHLYGTVLADVFARYQRLRGYDVLFVTGTDEHGTKIEQ---------------------------- 55
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502481621 134 gkstkAADQQPVSrPNfiELCHELTvedeKAFEALFRRLGLSLDwnYQYRTIDDNARATSQQAFLRNLQRGEAYSAEAPG 213
Cdd:cd00814 56 -----KAEEEGVT-PQ--ELCDKYH----EIFKDLFKWLNISFD--YFIRTTSPRHKEIVQEFFKKLYENGYIYEGEYEG 121
|
....
gi 502481621 214 LWDV 217
Cdd:cd00814 122 LYCV 125
|
|
| PLN02959 |
PLN02959 |
aminoacyl-tRNA ligase |
545-837 |
3.52e-12 |
|
aminoacyl-tRNA ligase
Pssm-ID: 215518 [Multi-domain] Cd Length: 1084 Bit Score: 70.48 E-value: 3.52e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502481621 545 FEMVFPMDMRPQGHDIIRTWL-FS----TIVRAHHehgtvPWWNA-TLNGWILdPDRKKMSKSKGNVVTPVDLLEEHGSD 618
Cdd:PLN02959 666 FEYWYPFDLRVSGKDLIQNHLtFAiynhTAIWAEE-----HWPRGfRCNGHLM-LNSEKMSKSTGNFLTLRQAIEEFSAD 739
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502481621 619 AVRYWAASARQGVDtafDAQQMKVGRRLAIklLNASKFALGFGEVDGAEH-----PEQLLAqvtepvDQSLLLELARVVE 693
Cdd:PLN02959 740 ATRFALADAGDGVD---DANFVFETANAAI--LRLTKEIAWMEEVLAAESslrtgPPSTYA------DRVFENEINIAIA 808
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502481621 694 QATAGFEAWDYTKALEvtEAFFwsfcddylELVKARayggDEVEASAATTSARAAL--RVAlDVQLRLLAPFIPFATEEV 771
Cdd:PLN02959 809 ETEKNYEAMMFREALK--SGFY--------DLQAAR----DEYRLSCGSGGMNRDLvwRFM-DVQTRLITPICPHYAEHV 873
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 502481621 772 WS--WWHSGSVHRAAWPTADE----VRPAN--LADVnVAGVKPAAAAVLAGIRKAKseaKLGMRAQVTAMTLAG 837
Cdd:PLN02959 874 WReiLKKEGFAVTAGWPVAGEpdltLKRANkyLQDS-IVSFRKLLQKQLAGSKKAK---KGGAPVTLPEKKLAG 943
|
|
| tRNA-synt_1g |
pfam09334 |
tRNA synthetases class I (M); This family includes methionyl tRNA synthetases. |
52-217 |
1.16e-11 |
|
tRNA synthetases class I (M); This family includes methionyl tRNA synthetases.
Pssm-ID: 401322 [Multi-domain] Cd Length: 387 Bit Score: 67.70 E-value: 1.16e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502481621 52 FTIDTPPPTASGSLHVGHVFGYTQADCMARYKRMTGAEVFYPIGWDDNGLPTERrvqnyygvrgditqpyvegyeppqrg 131
Cdd:pfam09334 1 ILVTTALPYANGPPHLGHLYSYIPADIFARYLRLRGYDVLFVCGTDEHGTPIEL-------------------------- 54
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502481621 132 gdgkstkAADQQPVSRPNFIELCHEltvedekAFEALFRRLGLSLDwNYqYRTIDDNARATSQQAFLRNLQRGEAYSAEA 211
Cdd:pfam09334 55 -------KAEKEGITPEELVDRYHE-------IHREDFKKFNISFD-DY-GRTTSERHHELVQEFFLKLYENGYIYEKEI 118
|
....*.
gi 502481621 212 PGLWDV 217
Cdd:pfam09334 119 EQFYCP 124
|
|
| PRK11893 |
PRK11893 |
methionyl-tRNA synthetase; Reviewed |
587-773 |
1.24e-09 |
|
methionyl-tRNA synthetase; Reviewed
Pssm-ID: 237012 [Multi-domain] Cd Length: 511 Bit Score: 61.82 E-value: 1.24e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502481621 587 NGWILDPDRKkMSKSKGNVVTPVDLLEEHGSDAVRYWAAS-ARQGVDTAFDAQQMkVGRRLAI------KLLNASkFALG 659
Cdd:PRK11893 290 HGFLTLDGEK-MSKSLGNVIDPFDLVDEYGVDAVRYFLLReIPFGQDGDFSREAF-INRINADlandlgNLAQRT-LSMI 366
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502481621 660 FGEVDGA-EHPEQLLAQvtepvDQSLLLELARVVEQATAGFEAWDYTKALEVTEAFFwSFCDDYLELVKA-RAYGGDEVE 737
Cdd:PRK11893 367 AKNFDGKvPEPGALTEA-----DEALLEAAAALLERVRAAMDNLAFDKALEAILALV-RAANKYIDEQAPwSLAKTDPER 440
|
170 180 190
....*....|....*....|....*....|....*..
gi 502481621 738 ASAATTSARAALR-VALdvqlrLLAPFIPFATEEVWS 773
Cdd:PRK11893 441 LATVLYTLLEVLRgIAV-----LLQPVMPELAAKILD 472
|
|
| PRK12267 |
PRK12267 |
methionyl-tRNA synthetase; Reviewed |
540-622 |
1.94e-09 |
|
methionyl-tRNA synthetase; Reviewed
Pssm-ID: 237028 [Multi-domain] Cd Length: 648 Bit Score: 61.35 E-value: 1.94e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502481621 540 NDPELFEMVFPMDMRPQGHDIIRtwlFSTI----------------VRAHhehgtvpwwnatlnGWILDPDRKkMSKSKG 603
Cdd:PRK12267 244 DDDELFKKFWPADVHLVGKDILR---FHAIywpimlmalglplpkkVFAH--------------GWWLMKDGK-MSKSKG 305
|
90
....*....|....*....
gi 502481621 604 NVVTPVDLLEEHGSDAVRY 622
Cdd:PRK12267 306 NVVDPEELVDRYGLDALRY 324
|
|
| Anticodon_Ia_Leu_AEc |
cd07959 |
Anticodon-binding domain of archaeal and eukaryotic cytoplasmic leucyl tRNA synthetases; This ... |
677-774 |
2.48e-09 |
|
Anticodon-binding domain of archaeal and eukaryotic cytoplasmic leucyl tRNA synthetases; This domain is found in leucyl tRNA synthetases (LeuRS), which belong to the class Ia aminoacyl tRNA synthetases. It lies C-terminal to the catalytic core domain. In contrast to other class Ia enzymes, the anticodon is not used as an identity element in LeuRS (with exceptions such as Saccharomyces cerevisiae and some other eukaryotes). No anticodon-binding site can be defined for this family, which includes archaeal and eukaryotic cytoplasmic members. LeuRS catalyzes the transfer of leucine to the 3'-end of its tRNA.
Pssm-ID: 153413 [Multi-domain] Cd Length: 117 Bit Score: 55.67 E-value: 2.48e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502481621 677 TEPVDQSLLLELARVVEQATAGFEAWDYTKALevTEAFF--WSFCDDYLELVKARAYGGdeveasaattsaraALRVALD 754
Cdd:cd07959 33 LTFIDRWLLSRLNRLIKETTEAYENMQFREAL--KEGLYelQNDLDWYRERGGAGMNKD--------------LLRRFIE 96
|
90 100
....*....|....*....|
gi 502481621 755 VQLRLLAPFIPFATEEVWSW 774
Cdd:cd07959 97 VWTRLLAPFAPHLAEEIWHE 116
|
|
| Anticodon_Ia_Ile_BEm |
cd07960 |
Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; ... |
649-791 |
3.00e-09 |
|
Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; This domain is found in isoleucyl tRNA synthetases (IleRS), which belong to the class Ia aminoacyl tRNA synthetases. It lies C-terminal to the catalytic core domain, and recognizes and specifically binds to the tRNA anticodon. This family includes bacterial and eukaryotic mitochondrial members. IleRS catalyzes the transfer of isoleucine to the 3'-end of its tRNA.
Pssm-ID: 153414 [Multi-domain] Cd Length: 180 Bit Score: 57.15 E-value: 3.00e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502481621 649 KLLNASKFALG----FGEVDGAEHPEQLLaqvtePVDQSLLLELARVVEQATAGFEAWDYTKALEVTEAF----FWSFcd 720
Cdd:cd07960 15 KIRNTFRFLLGnlndFDPAKDAVPYEELL-----ELDRYALHRLNELIKEVREAYENYEFHKVYQALNNFctvdLSAF-- 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502481621 721 dYLELVKARAY--GGDEVEasaattsaraalRVA--------LDVQLRLLAPFIPFATEEVWS----WWHSGSVHRAAWP 786
Cdd:cd07960 88 -YLDIIKDRLYcdAKDSLE------------RRSaqtvlyhiLDALLKLLAPILPFTAEEVWEhlpgEKKEESVFLEDWP 154
|
....*
gi 502481621 787 TADEV 791
Cdd:cd07960 155 ELPEE 159
|
|
| PRK11893 |
PRK11893 |
methionyl-tRNA synthetase; Reviewed |
52-214 |
7.69e-09 |
|
methionyl-tRNA synthetase; Reviewed
Pssm-ID: 237012 [Multi-domain] Cd Length: 511 Bit Score: 59.13 E-value: 7.69e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502481621 52 FTIDTPPPTASGSLHVGHVFGYTQADCMARYKRMTGAEVFYPIGWDDNGLpterrvqnyygvrgditqpYVEgyeppqrg 131
Cdd:PRK11893 3 FYITTPIYYPNGKPHIGHAYTTLAADVLARFKRLRGYDVFFLTGTDEHGQ-------------------KIQ-------- 55
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502481621 132 gdgkstKAADQQPVSrPnfIELCHELTvedeKAFEALFRRLGLSLDwnYQYRTIDDNARATSQQAFLRNLQRGEAYSAEA 211
Cdd:PRK11893 56 ------RKAEEAGIS-P--QELADRNS----AAFKRLWEALNISYD--DFIRTTDPRHKEAVQEIFQRLLANGDIYLGKY 120
|
...
gi 502481621 212 PGL 214
Cdd:PRK11893 121 EGW 123
|
|
| MetRS_core |
cd00814 |
catalytic core domain of methioninyl-tRNA synthetases; Methionine tRNA synthetase (MetRS) ... |
538-635 |
2.37e-08 |
|
catalytic core domain of methioninyl-tRNA synthetases; Methionine tRNA synthetase (MetRS) catalytic core domain. This class I enzyme aminoacylates the 2'-OH of the nucleotide at the 3' of the appropriate tRNA. MetRS, which consists of the core domain and an anti-codon binding domain, functions as a monomer. However, in some species the anti-codon binding domain is followed by an EMAP domain. In this case, MetRS functions as a homodimer. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains the characteristic class I HIGH and KMSKS motifs, which are involved in ATP binding. As a result of a deletion event, MetRS has a significantly shorter core domain insertion than IleRS, ValRS, and LeuR. Consequently, the MetRS insertion lacks the editing function.
Pssm-ID: 173907 [Multi-domain] Cd Length: 319 Bit Score: 56.77 E-value: 2.37e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502481621 538 WRNDPELFEMVfpmdmrpqGHDIIRtwlFSTI-------------VRAHHEHGtvpWWnaTLNGwildpdrKKMSKSKGN 604
Cdd:cd00814 231 KDGWPELVHFI--------GKDIIR---FHAIywpamllgaglplPTRIVAHG---YL--TVEG-------KKMSKSRGN 287
|
90 100 110
....*....|....*....|....*....|..
gi 502481621 605 VVTPVDLLEEHGSDAVRYW-AASARQGVDTAF 635
Cdd:cd00814 288 VVDPDDLLERYGADALRYYlLRERPEGKDSDF 319
|
|
| Anticodon_Ia_Ile_ABEc |
cd07961 |
Anticodon-binding domain of archaeal, bacterial, and eukaryotic cytoplasmic isoleucyl tRNA ... |
650-790 |
4.56e-08 |
|
Anticodon-binding domain of archaeal, bacterial, and eukaryotic cytoplasmic isoleucyl tRNA synthetases; This domain is found in isoleucyl tRNA synthetases (IleRS), which belong to the class Ia aminoacyl tRNA synthetases. It lies C-terminal to the catalytic core domain, and recognizes and specifically binds to the tRNA anticodon. This family includes bacterial, archaeal, and eukaryotic cytoplasmic members. IleRS catalyzes the transfer of isoleucine to the 3'-end of its tRNA.
Pssm-ID: 153415 [Multi-domain] Cd Length: 183 Bit Score: 53.71 E-value: 4.56e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502481621 650 LLNASKFALGFGEVDGAEHPEQLLAQVTEPV-DQSLLLELARVVEQATAGFEAWDYTKALEVTEaffwSFCDD----YLE 724
Cdd:cd07961 17 LWNAYRFFVTYANLDGFDPGKDDDAVASLNVlDRWILSRLNSLIKEVTEEMEAYDLYTAVRALL----EFIDEltnwYIR 92
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 502481621 725 LVKARAYGGDEVEASAATtsaraaLRV---ALDVQLRLLAPFIPFATEEVW------SWWHSGSVHRAAWPTADE 790
Cdd:cd07961 93 RNRKRFWGEEGDDDKLAA------YATlyeVLLTLSRLMAPFTPFITEEIYqnlrreLGDAPESVHLLDWPEVDE 161
|
|
| metG |
PRK00133 |
methionyl-tRNA synthetase; Reviewed |
59-204 |
9.35e-08 |
|
methionyl-tRNA synthetase; Reviewed
Pssm-ID: 234655 [Multi-domain] Cd Length: 673 Bit Score: 55.93 E-value: 9.35e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502481621 59 PTASGSLHVGHVFGYTQADCMARYKRMTGAEVFYpIGWDDN-GLPTERRvqnyygvrgditqpyvegyeppqrggdgkst 137
Cdd:PRK00133 11 PYANGPIHLGHLVEYIQADIWVRYQRMRGHEVLF-VCADDAhGTPIMLK------------------------------- 58
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 502481621 138 kaADQQPVSRPNFIELCHELTVEDekafealFRRLGLSLDwNYqYRTIDDNARATSQQAFLRNLQRG 204
Cdd:PRK00133 59 --AEKEGITPEELIARYHAEHKRD-------FAGFGISFD-NY-GSTHSEENRELAQEIYLKLKENG 114
|
|
| CysS |
COG0215 |
Cysteinyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Cysteinyl-tRNA ... |
587-674 |
9.68e-07 |
|
Cysteinyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Cysteinyl-tRNA synthetase is part of the Pathway/BioSystem: Aminoacyl-tRNA synthetases
Pssm-ID: 439985 [Multi-domain] Cd Length: 465 Bit Score: 52.41 E-value: 9.68e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502481621 587 NGWILDpDRKKMSKSKGNVVTPVDLLEEHGSDAVRYWAASA--RQGVDTAFDA-QQMKVG-RRL--AIKLLNASKFALGF 660
Cdd:COG0215 256 NGFLTV-NGEKMSKSLGNFFTVRDLLKKYDPEVLRFFLLSAhyRSPLDFSEEAlEEAEKAlERLynALRRLEEALGAADS 334
|
90
....*....|....
gi 502481621 661 GEVDGAEHPEQLLA 674
Cdd:COG0215 335 SAEEIEELREEFIA 348
|
|
| PRK12267 |
PRK12267 |
methionyl-tRNA synthetase; Reviewed |
52-105 |
1.15e-06 |
|
methionyl-tRNA synthetase; Reviewed
Pssm-ID: 237028 [Multi-domain] Cd Length: 648 Bit Score: 52.50 E-value: 1.15e-06
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....*.
gi 502481621 52 FTIDTPPPTASGSLHVGHVfgYTQ--ADCMARYKRMTGAEVFYPIGWDDNGLPTER 105
Cdd:PRK12267 6 FYITTPIYYPNGKPHIGHA--YTTiaADALARYKRLQGYDVFFLTGTDEHGQKIQQ 59
|
|
| CysRS_core |
cd00672 |
catalytic core domain of cysteinyl tRNA synthetase; Cysteinyl tRNA synthetase (CysRS) ... |
557-623 |
2.65e-05 |
|
catalytic core domain of cysteinyl tRNA synthetase; Cysteinyl tRNA synthetase (CysRS) catalytic core domain. This class I enzyme is a monomer which aminoacylates the 2'-OH of the nucleotide at the 3' of the appropriate tRNA. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains the characteristic class I HIGH and KMSKS motifs, which are involved in ATP binding.
Pssm-ID: 173899 [Multi-domain] Cd Length: 213 Bit Score: 46.03 E-value: 2.65e-05
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 502481621 557 GHDIIRTWLfstivraHHEHGTVpwwnatlngwildpDRKKMSKSKGNVVTPVDLLEEHGSDAVRYW 623
Cdd:cd00672 155 GKPFARYWL-------HTGHLTI--------------DGEKMSKSLGNFITVRDALKKYDPEVLRLA 200
|
|
| metG |
PRK00133 |
methionyl-tRNA synthetase; Reviewed |
585-773 |
4.16e-05 |
|
methionyl-tRNA synthetase; Reviewed
Pssm-ID: 234655 [Multi-domain] Cd Length: 673 Bit Score: 47.45 E-value: 4.16e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502481621 585 TLNGwildpdrKKMSKSKGNVVTPVDLLEEHGSDAVRYWAASARQG----VDTAFDAQQMKVGRRLAIKLLNASKFALGF 660
Cdd:PRK00133 324 TVEG-------AKMSKSRGTFIWARTYLDHLDPDYLRYYLAAKLPEtiddLDFNWEDFQQRVNSELVGKVVNFASRTAGF 396
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502481621 661 ------GEVDGAEhpeqllaqvtepVDQSLLLELARVVEQATAGFEAWDYTKAL-EVTE-AffwSFCDDYL------ELV 726
Cdd:PRK00133 397 inkrfdGKLPDAL------------ADPELLEEFEAAAEKIAEAYEAREFRKALrEIMAlA---DFANKYVddnepwKLA 461
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|..
gi 502481621 727 KARAYGGDEVeasaattsaraaLRVALdvQL-----RLLAPFIPFATEEVWS 773
Cdd:PRK00133 462 KQDGERLQAV------------CSVGL--NLfralaIYLKPVLPELAERAEA 499
|
|
| class_I_aaRS_core |
cd00802 |
catalytic core domain of class I amino acyl-tRNA synthetase; Class I amino acyl-tRNA ... |
56-108 |
4.48e-04 |
|
catalytic core domain of class I amino acyl-tRNA synthetase; Class I amino acyl-tRNA synthetase (aaRS) catalytic core domain. These enzymes are mostly monomers which aminoacylate the 2'-OH of the nucleotide at the 3' of the appropriate tRNA. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains the characteristic class I HIGH and KMSKS motifs, which are involved in ATP binding.
Pssm-ID: 173901 [Multi-domain] Cd Length: 143 Bit Score: 41.31 E-value: 4.48e-04
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|...
gi 502481621 56 TPPPTASGSLHVGHVFGYTQADCMARYKRMTGAEVFYPIGWDDNGLPTERRVQ 108
Cdd:cd00802 3 FSGITPNGYLHIGHLRTIVTFDFLAQAYRKLGYKVRCIALIDDAGGLIGDPAN 55
|
|
| lysK |
PRK00750 |
lysyl-tRNA synthetase; Reviewed |
589-613 |
1.02e-03 |
|
lysyl-tRNA synthetase; Reviewed
Pssm-ID: 234829 [Multi-domain] Cd Length: 510 Bit Score: 42.49 E-value: 1.02e-03
10 20
....*....|....*....|....*
gi 502481621 589 WILDPDRKKMSKSKGNVVTPVDLLE 613
Cdd:PRK00750 272 LFLDKKGEKISKSKGNVITIEDWLE 296
|
|
| LysRS_core_class_I |
cd00674 |
catalytic core domain of class I lysyl tRNA synthetase; Class I lysyl tRNA synthetase (LysRS) ... |
589-636 |
1.10e-03 |
|
catalytic core domain of class I lysyl tRNA synthetase; Class I lysyl tRNA synthetase (LysRS) catalytic core domain. This class I enzyme is a monomer which aminoacylates the 2'-OH of the nucleotide at the 3' of the appropriate tRNA. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains the characteristic class I HIGH and KMSKS motifs, which are involved in ATP binding. The class I LysRS is found only in archaea and some bacteria and has evolved separately from class II LysRS, as the two do not share structural or sequence similarity.
Pssm-ID: 173900 [Multi-domain] Cd Length: 353 Bit Score: 42.31 E-value: 1.10e-03
10 20 30 40
....*....|....*....|....*....|....*....|....*....
gi 502481621 589 WILDPDRKKMSKSKGNVVTPVDLLEEHGSDAVRY-WAASARQGVDTAFD 636
Cdd:cd00674 267 FIGLKGGGKMSSSKGNVITPSDWLEVAPPEVLRYlYARRKNPEKHIGFD 315
|
|
| tRNA-synt_1f |
pfam01921 |
tRNA synthetases class I (K); This family includes only lysyl tRNA synthetases from ... |
589-613 |
2.21e-03 |
|
tRNA synthetases class I (K); This family includes only lysyl tRNA synthetases from prokaryotes.
Pssm-ID: 396483 Cd Length: 357 Bit Score: 41.09 E-value: 2.21e-03
10 20
....*....|....*....|....*
gi 502481621 589 WILDPDRKKMSKSKGNVVTPVDLLE 613
Cdd:pfam01921 271 LILLKGGGKMSSSKGNVITPEDWLE 295
|
|
| ArgS |
COG0018 |
Arginyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Arginyl-tRNA ... |
586-700 |
4.54e-03 |
|
Arginyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Arginyl-tRNA synthetase is part of the Pathway/BioSystem: Aminoacyl-tRNA synthetases
Pssm-ID: 439789 [Multi-domain] Cd Length: 574 Bit Score: 40.52 E-value: 4.54e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502481621 586 LNGWILDPDRKKMSKSKGNVVTPVDLLEEH-----------------------GSDAVRYW--AASARQGVDtaFDAQQM 640
Cdd:COG0018 368 LFGMVNLRDGEKMSTRAGTVVTLDDLLDEAverareiieekseeekeeiaeqvGIDAVRYFdlSRSRDKDLD--FDLDLA 445
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502481621 641 K-------------------VGRRLAIKLLNASKFAlgfgevdgaehpeqlLAQVTEPVDQSLLLELAR---VVEQATAG 698
Cdd:COG0018 446 LsfegntnpyvqyaharicsILRKAGEELDGLAEAD---------------LSLLTEEEELALIKKLAQfpeVVEEAAED 510
|
..
gi 502481621 699 FE 700
Cdd:COG0018 511 LE 512
|
|
| LysS |
COG1384 |
Lysyl-tRNA synthetase, class I [Translation, ribosomal structure and biogenesis]; Lysyl-tRNA ... |
589-613 |
5.08e-03 |
|
Lysyl-tRNA synthetase, class I [Translation, ribosomal structure and biogenesis]; Lysyl-tRNA synthetase, class I is part of the Pathway/BioSystem: Aminoacyl-tRNA synthetases
Pssm-ID: 440994 [Multi-domain] Cd Length: 525 Bit Score: 40.56 E-value: 5.08e-03
10 20
....*....|....*....|....*
gi 502481621 589 WILDPDRKKMSKSKGNVVTPVDLLE 613
Cdd:COG1384 279 LFLDENGEKISKSKGNGLTVEEWLE 303
|
|
| argS |
PRK01611 |
arginyl-tRNA synthetase; Reviewed |
588-622 |
8.84e-03 |
|
arginyl-tRNA synthetase; Reviewed
Pssm-ID: 234964 [Multi-domain] Cd Length: 507 Bit Score: 39.75 E-value: 8.84e-03
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|..
gi 502481621 588 GWILDPDRKKMSKSKGNVVTPVDLLEEH-----------------GSDAVRY 622
Cdd:PRK01611 313 GLVRGGEGVKMSTRAGNVVTLDDLLDEAvgrarelieekeiaeavGIDAVRY 364
|
|
| |
