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Conserved domains on  [gi|502610370|ref|WP_012847380|]
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lipid asymmetry maintenance protein MlaB [Edwardsiella piscicida]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
mlaB_1 NF033618
lipid asymmetry maintenance protein MlaB; MlaB belongs to a system that maintains asymmetry in ...
 5-96 7.88e-42

lipid asymmetry maintenance protein MlaB; MlaB belongs to a system that maintains asymmetry in the outer membrane of Gram-negative bacteria, with LPS in the outer leaflet and phospholipids in the inner leaflet. Several components of the system share homology with typical ABC transporters.


:

Pssm-ID: 411237  Cd Length: 94  Bit Score: 132.24  E-value: 7.88e-42
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502610370   5 GELRWRRVDATLYLQGALECDSLDALWQQRQTLLTDITCVDISELSRVDSAGLALLLHVQNL--RPETPIPLRGVSERLR 82
Cdd:NF033618   1 EALSWEREGDTLALSGELDRDTLLPLWQQREELLAGVTCIDVSGLERVDSAGLALLVHLRAEarQQGRELKISGVSDRLR 80

                         90
                 ....*....|....
gi 502610370  83 TLITLYNLQDIVVC 96
Cdd:NF033618  81 TLITLYNLPEIILP 94
 
Name Accession Description Interval E-value
mlaB_1 NF033618
lipid asymmetry maintenance protein MlaB; MlaB belongs to a system that maintains asymmetry in ...
 5-96 7.88e-42

lipid asymmetry maintenance protein MlaB; MlaB belongs to a system that maintains asymmetry in the outer membrane of Gram-negative bacteria, with LPS in the outer leaflet and phospholipids in the inner leaflet. Several components of the system share homology with typical ABC transporters.


Pssm-ID: 411237  Cd Length: 94  Bit Score: 132.24  E-value: 7.88e-42
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502610370   5 GELRWRRVDATLYLQGALECDSLDALWQQRQTLLTDITCVDISELSRVDSAGLALLLHVQNL--RPETPIPLRGVSERLR 82
Cdd:NF033618   1 EALSWEREGDTLALSGELDRDTLLPLWQQREELLAGVTCIDVSGLERVDSAGLALLVHLRAEarQQGRELKISGVSDRLR 80

                         90
                 ....*....|....
gi 502610370  83 TLITLYNLQDIVVC 96
Cdd:NF033618  81 TLITLYNLPEIILP 94
MlaB COG3113
Binding protein subunit MlaB of the ABC-type intermembrane phospholipid transporter Mla, ...
 6-94 5.91e-21

Binding protein subunit MlaB of the ABC-type intermembrane phospholipid transporter Mla, contains STAS domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442347 [Multi-domain]  Cd Length: 97  Bit Score: 79.52  E-value: 5.91e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502610370   6 ELRWRRVDATLYLQGALECDSLDALWQQRQTLLT--DITCVDISELSRVDSAGLALLLHVQNLRPE--TPIPLRGVSERL 81
Cdd:COG3113    4 ALLWNAEGGTLRLSGELTRDTVLALWAQLLALLAagGAVEIDLSGVTRVDSAGLALLLELLREARAqgKTLRLTGVPEQL 83

                         90
                 ....*....|...
gi 502610370  82 RTLITLYNLQDIV 94
Cdd:COG3113   84 RTLAALYGLDELL 96
STAS_anti-anti-sigma_factors cd07043
Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key ...
 14-98 3.06e-05

Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Anti-anti-sigma factors play an important role in the regulation of several sigma factors and their corresponding anti-sigma factors. Upon dephosphorylation they bind the anti-sigma factor and induce the release of the sigma factor from the anti-sigma factor. In a feedback mechanism the anti-anti-sigma factor can be inactivated via phosphorylation by the anti-sigma factor. Well studied examples from Bacillus subtilis are SpoIIAA (regulating sigmaF and sigmaC which play an important role in sporulation) and RsbV (regulating sigmaB involved in the general stress response). The STAS domain is also found in the C- terminal region of sulphate transporters and stressosomes.


Pssm-ID: 132914 [Multi-domain]  Cd Length: 99  Bit Score: 39.43  E-value: 3.06e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502610370  14 ATLYLQGALECDSLDALWQQRQTLLTDIT---CVDISELSRVDSAGLALLLHVQNLRPETPIPLR--GVSERLRTLITLY 88
Cdd:cd07043   10 LVVRLSGELDAATAPELREALEELLAEGPrrlVLDLSGVTFIDSSGLGVLLGAYKRARAAGGRLVlvNVSPAVRRVLELT 89

                         90
                 ....*....|
gi 502610370  89 NLQDIVVCAA 98
Cdd:cd07043   90 GLDRLFPIYP 99
STAS_2 pfam13466
STAS domain; The STAS (after Sulphate Transporter and AntiSigma factor antagonist) domain is ...
 18-91 3.27e-05

STAS domain; The STAS (after Sulphate Transporter and AntiSigma factor antagonist) domain is found in the C-terminal region of Sulphate transporters and bacterial antisigma factor antagonists. It has been suggested that this domain may have a general NTP binding function.


Pssm-ID: 433231 [Multi-domain]  Cd Length: 80  Bit Score: 38.74  E-value: 3.27e-05
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 502610370   18 LQGALECDSLDALWQQRQTLLT--DITCVDISELSRVDSAGLALLLHVQNLRPET--PIPLRGVSERLRTLITLYNLQ 91
Cdd:pfam13466   3 LSGELDADTAPALREALLAALAagSPVVVDLSGVERVDSAGLALLLALARRARARgkRLVLRGLPPALLRLLRLLGLD 80
 
Name Accession Description Interval E-value
mlaB_1 NF033618
lipid asymmetry maintenance protein MlaB; MlaB belongs to a system that maintains asymmetry in ...
 5-96 7.88e-42

lipid asymmetry maintenance protein MlaB; MlaB belongs to a system that maintains asymmetry in the outer membrane of Gram-negative bacteria, with LPS in the outer leaflet and phospholipids in the inner leaflet. Several components of the system share homology with typical ABC transporters.


Pssm-ID: 411237  Cd Length: 94  Bit Score: 132.24  E-value: 7.88e-42
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502610370   5 GELRWRRVDATLYLQGALECDSLDALWQQRQTLLTDITCVDISELSRVDSAGLALLLHVQNL--RPETPIPLRGVSERLR 82
Cdd:NF033618   1 EALSWEREGDTLALSGELDRDTLLPLWQQREELLAGVTCIDVSGLERVDSAGLALLVHLRAEarQQGRELKISGVSDRLR 80

                         90
                 ....*....|....
gi 502610370  83 TLITLYNLQDIVVC 96
Cdd:NF033618  81 TLITLYNLPEIILP 94
MlaB COG3113
Binding protein subunit MlaB of the ABC-type intermembrane phospholipid transporter Mla, ...
 6-94 5.91e-21

Binding protein subunit MlaB of the ABC-type intermembrane phospholipid transporter Mla, contains STAS domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442347 [Multi-domain]  Cd Length: 97  Bit Score: 79.52  E-value: 5.91e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502610370   6 ELRWRRVDATLYLQGALECDSLDALWQQRQTLLT--DITCVDISELSRVDSAGLALLLHVQNLRPE--TPIPLRGVSERL 81
Cdd:COG3113    4 ALLWNAEGGTLRLSGELTRDTVLALWAQLLALLAagGAVEIDLSGVTRVDSAGLALLLELLREARAqgKTLRLTGVPEQL 83

                         90
                 ....*....|...
gi 502610370  82 RTLITLYNLQDIV 94
Cdd:COG3113   84 RTLAALYGLDELL 96
STAS_anti-anti-sigma_factors cd07043
Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key ...
 14-98 3.06e-05

Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Anti-anti-sigma factors play an important role in the regulation of several sigma factors and their corresponding anti-sigma factors. Upon dephosphorylation they bind the anti-sigma factor and induce the release of the sigma factor from the anti-sigma factor. In a feedback mechanism the anti-anti-sigma factor can be inactivated via phosphorylation by the anti-sigma factor. Well studied examples from Bacillus subtilis are SpoIIAA (regulating sigmaF and sigmaC which play an important role in sporulation) and RsbV (regulating sigmaB involved in the general stress response). The STAS domain is also found in the C- terminal region of sulphate transporters and stressosomes.


Pssm-ID: 132914 [Multi-domain]  Cd Length: 99  Bit Score: 39.43  E-value: 3.06e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502610370  14 ATLYLQGALECDSLDALWQQRQTLLTDIT---CVDISELSRVDSAGLALLLHVQNLRPETPIPLR--GVSERLRTLITLY 88
Cdd:cd07043   10 LVVRLSGELDAATAPELREALEELLAEGPrrlVLDLSGVTFIDSSGLGVLLGAYKRARAAGGRLVlvNVSPAVRRVLELT 89

                         90
                 ....*....|
gi 502610370  89 NLQDIVVCAA 98
Cdd:cd07043   90 GLDRLFPIYP 99
STAS_2 pfam13466
STAS domain; The STAS (after Sulphate Transporter and AntiSigma factor antagonist) domain is ...
 18-91 3.27e-05

STAS domain; The STAS (after Sulphate Transporter and AntiSigma factor antagonist) domain is found in the C-terminal region of Sulphate transporters and bacterial antisigma factor antagonists. It has been suggested that this domain may have a general NTP binding function.


Pssm-ID: 433231 [Multi-domain]  Cd Length: 80  Bit Score: 38.74  E-value: 3.27e-05
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 502610370   18 LQGALECDSLDALWQQRQTLLT--DITCVDISELSRVDSAGLALLLHVQNLRPET--PIPLRGVSERLRTLITLYNLQ 91
Cdd:pfam13466   3 LSGELDADTAPALREALLAALAagSPVVVDLSGVERVDSAGLALLLALARRARARgkRLVLRGLPPALLRLLRLLGLD 80
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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