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Conserved domains on  [gi|502627133|ref|WP_012863831|]
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MULTISPECIES: PepSY domain-containing protein [Veillonella]

Protein Classification

PepSY domain-containing protein( domain architecture ID 11461384)

PepSY (peptidase propeptide and YPEB) domain-containing protein may act as a regulator of peptidase activity and may also function in protecting the cell from lysis; similar to Bacillus subtilis uncharacterized protein YkoJ and YkoI

CATH:  3.10.450.40
PubMed:  15124630

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
YkoI COG3212
PepSY domain containing protein, regulator of zincin peptidase activity [Posttranslational ...
 121-187 8.16e-11

PepSY domain containing protein, regulator of zincin peptidase activity [Posttranslational modification, protein turnover, chaperones];


:

Pssm-ID: 442445  Cd Length: 66  Bit Score: 55.21  E-value: 8.16e-11
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 502627133 121 EILPPAAVVNFAYAQTKGKAVslnEWAVRYDKGKIVYKVSFGTEDNKEVHVRMDAMNGKLLSVKFDD 187
Cdd:COG3212    3 AIISLEQALEIALARVPGRVL---EVELERDDGRLVYEVEILTPDGRVYEVEVDAKTGEVLKVEEDD 66
 
Name Accession Description Interval E-value
YkoI COG3212
PepSY domain containing protein, regulator of zincin peptidase activity [Posttranslational ...
 121-187 8.16e-11

PepSY domain containing protein, regulator of zincin peptidase activity [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 442445  Cd Length: 66  Bit Score: 55.21  E-value: 8.16e-11
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 502627133 121 EILPPAAVVNFAYAQTKGKAVslnEWAVRYDKGKIVYKVSFGTEDNKEVHVRMDAMNGKLLSVKFDD 187
Cdd:COG3212    3 AIISLEQALEIALARVPGRVL---EVELERDDGRLVYEVEILTPDGRVYEVEVDAKTGEVLKVEEDD 66
PepSY pfam03413
Peptidase propeptide and YPEB domain; This region is likely to have an protease inhibitory ...
 122-184 2.56e-03

Peptidase propeptide and YPEB domain; This region is likely to have an protease inhibitory function (personal obs:C Yeats). This model is likely to miss some members of this family as the separation from signal to noise is not clear. The name is derived from Peptidase _ Bacillus subtilis YPEB.


Pssm-ID: 427284 [Multi-domain]  Cd Length: 59  Bit Score: 34.96  E-value: 2.56e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 502627133  122 ILPPAAVVNFAYAQTKGKAVslnEWAVRYDKGKIVYKVSfGTEDNKEVHVRMDAMNGKLLSVK 184
Cdd:pfam03413   1 KISLEQALAIALKAVPGAVI---EAELEPEDGKLVYEVE-VDPDGREYEVYIDAYTGEVLKVE 59
 
Name Accession Description Interval E-value
YkoI COG3212
PepSY domain containing protein, regulator of zincin peptidase activity [Posttranslational ...
 121-187 8.16e-11

PepSY domain containing protein, regulator of zincin peptidase activity [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 442445  Cd Length: 66  Bit Score: 55.21  E-value: 8.16e-11
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 502627133 121 EILPPAAVVNFAYAQTKGKAVslnEWAVRYDKGKIVYKVSFGTEDNKEVHVRMDAMNGKLLSVKFDD 187
Cdd:COG3212    3 AIISLEQALEIALARVPGRVL---EVELERDDGRLVYEVEILTPDGRVYEVEVDAKTGEVLKVEEDD 66
PepSY pfam03413
Peptidase propeptide and YPEB domain; This region is likely to have an protease inhibitory ...
 122-184 2.56e-03

Peptidase propeptide and YPEB domain; This region is likely to have an protease inhibitory function (personal obs:C Yeats). This model is likely to miss some members of this family as the separation from signal to noise is not clear. The name is derived from Peptidase _ Bacillus subtilis YPEB.


Pssm-ID: 427284 [Multi-domain]  Cd Length: 59  Bit Score: 34.96  E-value: 2.56e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 502627133  122 ILPPAAVVNFAYAQTKGKAVslnEWAVRYDKGKIVYKVSfGTEDNKEVHVRMDAMNGKLLSVK 184
Cdd:pfam03413   1 KISLEQALAIALKAVPGAVI---EAELEPEDGKLVYEVE-VDPDGREYEVYIDAYTGEVLKVE 59
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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