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Conserved domains on  [gi|502643204|ref|WP_012879609|]
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polysaccharide biosynthesis tyrosine autokinase [Xylanimonas cellulosilytica]

Protein Classification

polysaccharide biosynthesis tyrosine autokinase( domain architecture ID 13405342)

polysaccharide biosynthesis tyrosine autokinase catalyzes the autophosphorylation on a C-terminal tyrosine cluster and also phosphorylates endogenous protein substrates by using ATP as phosphoryl donor; may also be involved in the production and transport of exopolysaccharides

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
YveK COG3944
Capsular polysaccharide biosynthesis protein YveK [Cell wall/membrane/envelope biogenesis];
1-317 7.46e-73

Capsular polysaccharide biosynthesis protein YveK [Cell wall/membrane/envelope biogenesis];


:

Pssm-ID: 443144 [Multi-domain]  Cd Length: 309  Bit Score: 233.81  E-value: 7.46e-73
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502643204   1 MELADYLSLLRKRWLSITVLTVLGLVAGLAASVLATPVFTARSQVFVSVRGSDTTSDLLQGSNFTVRQVRSYVQLVQTPR 80
Cdd:COG3944    2 MDLREYLRILRRRWWLILLLTLLGALAALASSFLITPVYQASTTLLVSTSSGSDASDLYQGIQTAQQLVNTYAELLKSPA 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502643204  81 VLQPVIEELGLTDTPSQLAERVRAESPLDTVLINVTADDESAQFAADIANSVARSLSAVVQELETPQGaaespveISTVR 160
Cdd:COG3944   82 VLEEVIDELGLDLSPEELAKKISVTSPPDTQVITITVTDTDPERAADIANAVAEVFAEEVKELMKVDN-------VTVLD 154

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502643204 161 SAVAPTSPSSPNTTMNLALGLLVGLALGVGVAVLREVLNTKMRDVADVEAVTEasVLGAIPFEPDAADSPLIVQESPHSL 240
Cdd:COG3944  155 PATVPASPVSPNPKLNLAIGLVLGLLLGVGLAFLRELLDTTIRSEEDIERLLG--LLLGGAVPAARSARPLLLLLADASP 232

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 502643204 241 RSEAFRRLRTNLQFLEFDRNQRAIVTTSALPGEGKTTTTINLAITLADAGQRVALVDADLRRPSIAKYMGLEGSVGL 317
Cdd:COG3944  233 RAAAARRRRRNLLFALAAVDARTVVVVSSSLSEGKSTTTAALALALAAAAAGVVLVLADLDRRRRVALLGLLEGAGL 309
BY-kinase cd05387
bacterial tyrosine-kinase; Bacterial tyrosine (BY)-kinases catalyze the autophosphorylation on ...
 243-432 2.38e-65

bacterial tyrosine-kinase; Bacterial tyrosine (BY)-kinases catalyze the autophosphorylation on a C-terminal tyrosine cluster and also phosphorylate endogenous protein substrates by using ATP as phosphoryl donor. Besides their capacity to function as tyrosine kinase, most of these proteins are also involved in the production and transport of exopolysaccharides. BY-kinases are involved in a number of physiological processes ranging from stress resistance to pathogenicity.


:

Pssm-ID: 349772 [Multi-domain]  Cd Length: 190  Bit Score: 210.12  E-value: 2.38e-65
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502643204 243 EAFRRLRTNLQFLEFDRNQRAIVTTSALPGEGKTTTTINLAITLADAGQRVALVDADLRRPSIAKYMGLEGSVGLTTVLI 322
Cdd:cd05387    1 EAFRTLRTNLLFAGSDAGPKVIAVTSASPGEGKSTVAANLAVALAQSGKRVLLIDADLRRPSLHRLLGLPNEPGLSEVLS 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502643204 323 GRARLDDVAQPWGNGNLDVITSGQVPPNPSELLGSRNMDELLDELHAKYDVVLIDTSPLLPVTDGAILARLVGGAVVVVG 402
Cdd:cd05387   81 GQASLEDVIQSTNIPNLDVLPAGTVPPNPSELLSSPRFAELLEELKEQYDYVIIDTPPVLAVADALILAPLVDGVLLVVR 160

                        170       180       190
                 ....*....|....*....|....*....|
gi 502643204 403 AGTVHRQQVDGALQALDSVAARVLGVVVNR 432
Cdd:cd05387  161 AGKTRRREVKEALERLEQAGAKVLGVVLNK 190
 
Name Accession Description Interval E-value
YveK COG3944
Capsular polysaccharide biosynthesis protein YveK [Cell wall/membrane/envelope biogenesis];
1-317 7.46e-73

Capsular polysaccharide biosynthesis protein YveK [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 443144 [Multi-domain]  Cd Length: 309  Bit Score: 233.81  E-value: 7.46e-73
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502643204   1 MELADYLSLLRKRWLSITVLTVLGLVAGLAASVLATPVFTARSQVFVSVRGSDTTSDLLQGSNFTVRQVRSYVQLVQTPR 80
Cdd:COG3944    2 MDLREYLRILRRRWWLILLLTLLGALAALASSFLITPVYQASTTLLVSTSSGSDASDLYQGIQTAQQLVNTYAELLKSPA 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502643204  81 VLQPVIEELGLTDTPSQLAERVRAESPLDTVLINVTADDESAQFAADIANSVARSLSAVVQELETPQGaaespveISTVR 160
Cdd:COG3944   82 VLEEVIDELGLDLSPEELAKKISVTSPPDTQVITITVTDTDPERAADIANAVAEVFAEEVKELMKVDN-------VTVLD 154

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502643204 161 SAVAPTSPSSPNTTMNLALGLLVGLALGVGVAVLREVLNTKMRDVADVEAVTEasVLGAIPFEPDAADSPLIVQESPHSL 240
Cdd:COG3944  155 PATVPASPVSPNPKLNLAIGLVLGLLLGVGLAFLRELLDTTIRSEEDIERLLG--LLLGGAVPAARSARPLLLLLADASP 232

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 502643204 241 RSEAFRRLRTNLQFLEFDRNQRAIVTTSALPGEGKTTTTINLAITLADAGQRVALVDADLRRPSIAKYMGLEGSVGL 317
Cdd:COG3944  233 RAAAARRRRRNLLFALAAVDARTVVVVSSSLSEGKSTTTAALALALAAAAAGVVLVLADLDRRRRVALLGLLEGAGL 309
BY-kinase cd05387
bacterial tyrosine-kinase; Bacterial tyrosine (BY)-kinases catalyze the autophosphorylation on ...
 243-432 2.38e-65

bacterial tyrosine-kinase; Bacterial tyrosine (BY)-kinases catalyze the autophosphorylation on a C-terminal tyrosine cluster and also phosphorylate endogenous protein substrates by using ATP as phosphoryl donor. Besides their capacity to function as tyrosine kinase, most of these proteins are also involved in the production and transport of exopolysaccharides. BY-kinases are involved in a number of physiological processes ranging from stress resistance to pathogenicity.


Pssm-ID: 349772 [Multi-domain]  Cd Length: 190  Bit Score: 210.12  E-value: 2.38e-65
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502643204 243 EAFRRLRTNLQFLEFDRNQRAIVTTSALPGEGKTTTTINLAITLADAGQRVALVDADLRRPSIAKYMGLEGSVGLTTVLI 322
Cdd:cd05387    1 EAFRTLRTNLLFAGSDAGPKVIAVTSASPGEGKSTVAANLAVALAQSGKRVLLIDADLRRPSLHRLLGLPNEPGLSEVLS 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502643204 323 GRARLDDVAQPWGNGNLDVITSGQVPPNPSELLGSRNMDELLDELHAKYDVVLIDTSPLLPVTDGAILARLVGGAVVVVG 402
Cdd:cd05387   81 GQASLEDVIQSTNIPNLDVLPAGTVPPNPSELLSSPRFAELLEELKEQYDYVIIDTPPVLAVADALILAPLVDGVLLVVR 160

                        170       180       190
                 ....*....|....*....|....*....|
gi 502643204 403 AGTVHRQQVDGALQALDSVAARVLGVVVNR 432
Cdd:cd05387  161 AGKTRRREVKEALERLEQAGAKVLGVVLNK 190
eps_fam TIGR01007
capsular exopolysaccharide family; This model describes the capsular exopolysaccharide ...
 243-435 4.95e-44

capsular exopolysaccharide family; This model describes the capsular exopolysaccharide proteins in bacteria. The exopolysaccharide gene cluster consists of several genes which encode a number of proteins which regulate the exoploysaccharide biosynthesis(EPS). Atleast 13 genes espA to espM in streptococcus species seem to direct the EPS proteins and all of which share high homology. Functional roles were characterized by gene disruption experiments which resulted in exopolysaccharide-deficient phenotypes. [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]


Pssm-ID: 273392 [Multi-domain]  Cd Length: 204  Bit Score: 154.52  E-value: 4.95e-44
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502643204  243 EAFRRLRTNLQFLEFDrnQRAIVTTSALPGEGKTTTTINLAITLADAGQRVALVDADLRRPSIAKYMGLEGS-VGLTTVL 321
Cdd:TIGR01007   1 EYYNAIRTNIQFSGAE--IKVLLITSVKPGEGKSTTSANIAIAFAQAGYKTLLIDGDMRNSVMSGTFKSQNKiTGLTNFL 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502643204  322 IGRARLDDVAQPWGNGNLDVITSGQVPPNPSELLGSRNMDELLDELHAKYDVVLIDTSPLLPVTDGAILARLVGGAVVVV 401
Cdd:TIGR01007  79 SGTTDLSDAICDTNIENLDVITAGPVPPNPTELLQSSNFKTLIETLRKRFDYIIIDTPPIGTVTDAAIIARACDASILVT 158

                         170       180       190
                  ....*....|....*....|....*....|....
gi 502643204  402 GAGTVHRQQVDGALQALDSVAARVLGVVVNRAPT 435
Cdd:TIGR01007 159 DAGKIKKREVKKAKEQLEQAGSNFLGVVLNKVDI 192
eps_transp_fam TIGR01005
exopolysaccharide transport protein family; The model describes the exopolysaccharide ...
 159-432 3.81e-34

exopolysaccharide transport protein family; The model describes the exopolysaccharide transport protein family in bacteria. The transport protein is part of a large genetic locus which is associated with exopolysaccharide (EPS) biosynthesis. Detailed molecular characterization and gene fusion analysis revealed atleast seven gene products are involved in the overall regulation, which among other things, include exopolysaccharide biosynthesis, property of conferring virulence and exopolysaccharide export. [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]


Pssm-ID: 273391 [Multi-domain]  Cd Length: 764  Bit Score: 137.16  E-value: 3.81e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502643204  159 VRSAVAPTSPSSPNTTMNLALGLLVGLALGVGVAVLREVLNTKMRDVADVEAVTEASVLGAIPF---------------- 222
Cdd:TIGR01005 423 IDEAAVPEEPSKPKKLMTLALAAVLGMMLGGAAAAFLEALEGGFRDEGDIEEHLGHRSLATVPLldtqmdkkaqlthahf 502

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502643204  223 -----EPDAADSPL-------IVQESPHSLRSEAFRRLRTNLQFLEFDRNQRAIVTTSALPGEGKTTTTINLAITLADAG 290
Cdd:TIGR01005 503 gsvkrHDEAVDDTMpfqllarIVPDAPRSTFAEAFRNAKLACDFALADAENNLIAIAGALPDEGKSFIAANFAALIAAGG 582

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502643204  291 QRVALVDADLRRPSIAKYMGLEGSVGLTTVLIGRARLDDVAQPWGNGNLDVITSGQV---PPNPSELLGSRNMDELLDEL 367
Cdd:TIGR01005 583 KRTLLIDADIRKGGLHQMFGKAPKPGLLDLLAGEASIEAGIHRDQRPGLAFIAAGGAshfPHNPNELLANPAMAELIDNA 662

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 502643204  368 HAKYDVVLIDTSPLLPVTDGAILARLVGGAVVVVGAGTVHRQQVDGALQALDSVAARVLGVVVNR 432
Cdd:TIGR01005 663 RNAFDLVLVDLAALAAVADAAAFAALADGILFVTEFERSPLGEIRDLIHQEPHANSDVLGVIFNA 727
PRK11519 PRK11519
tyrosine-protein kinase Wzc;
229-431 1.20e-32

tyrosine-protein kinase Wzc;


Pssm-ID: 183173 [Multi-domain]  Cd Length: 719  Bit Score: 132.58  E-value: 1.20e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502643204 229 SPLIVQESPHSLRSEAFRRLRTNLQFLEFDRNQRAIVTTSALPGEGKTTTTINLAITLADAGQRVALVDADLRRPSIAKY 308
Cdd:PRK11519 494 SQLLAVGNPTDLAIEAIRSLRTSLHFAMMQAQNNVLMMTGVSPSIGKTFVCANLAAVISQTNKRVLLIDCDMRKGYTHEL 573

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502643204 309 MGLEGSVGLTTVLIGRARLDDVAQPWGNGNLDVITSGQVPPNPSELLGSRNMDELLDELHAKYDVVLIDTSPLLPVTDGA 388
Cdd:PRK11519 574 LGTNNVNGLSDILIGQGDITTAAKPTSIANFDLIPRGQVPPNPSELLMSERFAELVNWASKNYDLVLIDTPPILAVTDAA 653

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|...
gi 502643204 389 ILARLVGGAVVVVGAGTVHRQQVDGALQALDSVAARVLGVVVN 431
Cdd:PRK11519 654 IVGRHVGTTLMVARYAVNTLKEVETSLSRFEQNGIPVKGVILN 696
FlhG COG0455
MinD-like ATPase FlhG/YlxH, activator of the FlhF-type GTPase [Cell cycle control, cell ...
 277-380 1.64e-19

MinD-like ATPase FlhG/YlxH, activator of the FlhF-type GTPase [Cell cycle control, cell division, chromosome partitioning, Cell motility];


Pssm-ID: 440223 [Multi-domain]  Cd Length: 230  Bit Score: 87.64  E-value: 1.64e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502643204 277 TTTINLAITLADAGQRVALVDADLRRPSIAKYMGLEGSVGLTTVLIGRARLDDVAQPwGNGNLDVITSGQVPPNPSELLG 356
Cdd:COG0455    1 TVAVNLAAALARLGKRVLLVDADLGLANLDVLLGLEPKATLADVLAGEADLEDAIVQ-GPGGLDVLPGGSGPAELAELDP 79

                         90       100
                 ....*....|....*....|....
gi 502643204 357 SRNMDELLDELHAKYDVVLIDTSP 380
Cdd:COG0455   80 EERLIRVLEELERFYDVVLVDTGA 103
AAA_31 pfam13614
AAA domain; This family includes a wide variety of AAA domains including some that have lost ...
 272-382 1.86e-13

AAA domain; This family includes a wide variety of AAA domains including some that have lost essential nucleotide binding residues in the P-loop.


Pssm-ID: 433350 [Multi-domain]  Cd Length: 177  Bit Score: 68.76  E-value: 1.86e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502643204  272 GEGKTTTTINLAITLADAGQRVALVDADlrrPSIA--KYMGLEGSVGLTT---VLIGRARLDDVAQPWGNGNLDVITSG- 345
Cdd:pfam13614  12 GVGKTTTSVNLAAALAKKGKKVLLIDLD---PQGNatSGLGIDKNNVEKTiyeLLIGECNIEEAIIKTVIENLDLIPSNi 88

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 502643204  346 ---QVPPNPSELLGSRN-MDELLDELHAKYDVVLIDTSPLL 382
Cdd:pfam13614  89 dlaGAEIELIGIENRENiLKEALEPVKDNYDYIIIDCPPSL 129
ParA pfam10609
NUBPL iron-transfer P-loop NTPase; This family contains ATPases involved in plasmid ...
 272-313 1.56e-09

NUBPL iron-transfer P-loop NTPase; This family contains ATPases involved in plasmid partitioning. It also contains the cytosolic Fe-S cluster assembling factor NBP35 which is required for biogenesis and export of both ribosomal subunits.


Pssm-ID: 431392 [Multi-domain]  Cd Length: 246  Bit Score: 58.62  E-value: 1.56e-09
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 502643204  272 GEGKTTTTINLAITLADAGQRVALVDADLRRPSIAKYMGLEG 313
Cdd:pfam10609  14 GVGKSTVAVNLALALARLGYKVGLLDADIYGPSIPRMLGLEG 55
ParAB_family cd02042
partition proteins ParAB family; ParA and ParB of Caulobacter crescentus belong to a conserved ...
 272-299 2.11e-07

partition proteins ParAB family; ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the initiation of DNA replication. ParB regulates the ParA ATPase activity by promoting nucleotide exchange in a fashion reminiscent of the exchange factors of eukaryotic G proteins. ADP-bound ParA binds single-stranded DNA, whereas the ATP-bound form dissociates ParB from its DNA binding sites. Increasing the fraction of ParA-ADP in the cell inhibits cell division, suggesting that this simple nucleotide switch may regulate cytokinesis. ParA shares sequence similarity to a conserved and widespread family of ATPases which includes the repA protein of the repABC operon in Rhizobium etli symbiotic plasmid. This operon is involved in the plasmid replication and partition.


Pssm-ID: 349760 [Multi-domain]  Cd Length: 130  Bit Score: 49.85  E-value: 2.11e-07
                         10        20
                 ....*....|....*....|....*...
gi 502643204 272 GEGKTTTTINLAITLADAGQRVALVDAD 299
Cdd:cd02042   11 GVGKTTLAVNLAAALALRGKRVLLIDLD 38
ParA_partition NF041546
ParA family partition ATPase;
272-299 1.36e-05

ParA family partition ATPase;


Pssm-ID: 469431 [Multi-domain]  Cd Length: 202  Bit Score: 46.01  E-value: 1.36e-05
                         10        20
                 ....*....|....*....|....*...
gi 502643204 272 GEGKTTTTINLAITLADAGQRVALVDAD 299
Cdd:NF041546  10 GVGKTTLATHLAAALARRGYRVLLVDAD 37
PRK11670 PRK11670
iron-sulfur cluster carrier protein ApbC;
264-310 1.64e-05

iron-sulfur cluster carrier protein ApbC;


Pssm-ID: 183270 [Multi-domain]  Cd Length: 369  Bit Score: 46.96  E-value: 1.64e-05
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*..
gi 502643204 264 IVTTSALPGEGKTTTTINLAITLADAGQRVALVDADLRRPSIAKYMG 310
Cdd:PRK11670 110 IAVSSGKGGVGKSSTAVNLALALAAEGAKVGILDADIYGPSIPTMLG 156
 
Name Accession Description Interval E-value
YveK COG3944
Capsular polysaccharide biosynthesis protein YveK [Cell wall/membrane/envelope biogenesis];
1-317 7.46e-73

Capsular polysaccharide biosynthesis protein YveK [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 443144 [Multi-domain]  Cd Length: 309  Bit Score: 233.81  E-value: 7.46e-73
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502643204   1 MELADYLSLLRKRWLSITVLTVLGLVAGLAASVLATPVFTARSQVFVSVRGSDTTSDLLQGSNFTVRQVRSYVQLVQTPR 80
Cdd:COG3944    2 MDLREYLRILRRRWWLILLLTLLGALAALASSFLITPVYQASTTLLVSTSSGSDASDLYQGIQTAQQLVNTYAELLKSPA 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502643204  81 VLQPVIEELGLTDTPSQLAERVRAESPLDTVLINVTADDESAQFAADIANSVARSLSAVVQELETPQGaaespveISTVR 160
Cdd:COG3944   82 VLEEVIDELGLDLSPEELAKKISVTSPPDTQVITITVTDTDPERAADIANAVAEVFAEEVKELMKVDN-------VTVLD 154

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502643204 161 SAVAPTSPSSPNTTMNLALGLLVGLALGVGVAVLREVLNTKMRDVADVEAVTEasVLGAIPFEPDAADSPLIVQESPHSL 240
Cdd:COG3944  155 PATVPASPVSPNPKLNLAIGLVLGLLLGVGLAFLRELLDTTIRSEEDIERLLG--LLLGGAVPAARSARPLLLLLADASP 232

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 502643204 241 RSEAFRRLRTNLQFLEFDRNQRAIVTTSALPGEGKTTTTINLAITLADAGQRVALVDADLRRPSIAKYMGLEGSVGL 317
Cdd:COG3944  233 RAAAARRRRRNLLFALAAVDARTVVVVSSSLSEGKSTTTAALALALAAAAAGVVLVLADLDRRRRVALLGLLEGAGL 309
BY-kinase cd05387
bacterial tyrosine-kinase; Bacterial tyrosine (BY)-kinases catalyze the autophosphorylation on ...
 243-432 2.38e-65

bacterial tyrosine-kinase; Bacterial tyrosine (BY)-kinases catalyze the autophosphorylation on a C-terminal tyrosine cluster and also phosphorylate endogenous protein substrates by using ATP as phosphoryl donor. Besides their capacity to function as tyrosine kinase, most of these proteins are also involved in the production and transport of exopolysaccharides. BY-kinases are involved in a number of physiological processes ranging from stress resistance to pathogenicity.


Pssm-ID: 349772 [Multi-domain]  Cd Length: 190  Bit Score: 210.12  E-value: 2.38e-65
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502643204 243 EAFRRLRTNLQFLEFDRNQRAIVTTSALPGEGKTTTTINLAITLADAGQRVALVDADLRRPSIAKYMGLEGSVGLTTVLI 322
Cdd:cd05387    1 EAFRTLRTNLLFAGSDAGPKVIAVTSASPGEGKSTVAANLAVALAQSGKRVLLIDADLRRPSLHRLLGLPNEPGLSEVLS 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502643204 323 GRARLDDVAQPWGNGNLDVITSGQVPPNPSELLGSRNMDELLDELHAKYDVVLIDTSPLLPVTDGAILARLVGGAVVVVG 402
Cdd:cd05387   81 GQASLEDVIQSTNIPNLDVLPAGTVPPNPSELLSSPRFAELLEELKEQYDYVIIDTPPVLAVADALILAPLVDGVLLVVR 160

                        170       180       190
                 ....*....|....*....|....*....|
gi 502643204 403 AGTVHRQQVDGALQALDSVAARVLGVVVNR 432
Cdd:cd05387  161 AGKTRRREVKEALERLEQAGAKVLGVVLNK 190
Mrp COG0489
Fe-S cluster carrier ATPase, Mrp/ApbC/NBP35 family [Cell cycle control, cell division, ...
 195-439 4.91e-57

Fe-S cluster carrier ATPase, Mrp/ApbC/NBP35 family [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440255 [Multi-domain]  Cd Length: 289  Bit Score: 191.94  E-value: 4.91e-57
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502643204 195 REVLNTKMRDVADVEAVTEASVLGAIPFEPDAADSPLIVQESPHSLRSEAFRRLRTNLQFLEFDRNQRaIVTTSALPGEG 274
Cdd:COG0489   27 LLLRLEEAAAAAALAAAAPAAAAPAPLPPAPALLLLLLLLLGLLLLLLLALALLLLLLLLLLRLLLEV-IAVTSGKGGEG 105

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502643204 275 KTTTTINLAITLADAGQRVALVDADLRRPSIAKYMGLEGSVGLTTVLIGRARLDDVAQPWGNGNLDVITSGQVPPNPSEL 354
Cdd:COG0489  106 KSTVAANLALALAQSGKRVLLIDADLRGPSLHRMLGLENRPGLSDVLAGEASLEDVIQPTEVEGLDVLPAGPLPPNPSEL 185

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502643204 355 LGSRNMDELLDELHAKYDVVLIDTSPLLPVTDGAILARLVGGAVVVVGAGTVHRQQVDGALQALDSVAARVLGVVVNRAP 434
Cdd:COG0489  186 LASKRLKQLLEELRGRYDYVIIDTPPGLGVADATLLASLVDGVLLVVRPGKTALDDVRKALEMLEKAGVPVLGVVLNMVC 265


                 ....*
gi 502643204 435 TKGSG 439
Cdd:COG0489  266 PKGER 270
eps_fam TIGR01007
capsular exopolysaccharide family; This model describes the capsular exopolysaccharide ...
 243-435 4.95e-44

capsular exopolysaccharide family; This model describes the capsular exopolysaccharide proteins in bacteria. The exopolysaccharide gene cluster consists of several genes which encode a number of proteins which regulate the exoploysaccharide biosynthesis(EPS). Atleast 13 genes espA to espM in streptococcus species seem to direct the EPS proteins and all of which share high homology. Functional roles were characterized by gene disruption experiments which resulted in exopolysaccharide-deficient phenotypes. [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]


Pssm-ID: 273392 [Multi-domain]  Cd Length: 204  Bit Score: 154.52  E-value: 4.95e-44
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502643204  243 EAFRRLRTNLQFLEFDrnQRAIVTTSALPGEGKTTTTINLAITLADAGQRVALVDADLRRPSIAKYMGLEGS-VGLTTVL 321
Cdd:TIGR01007   1 EYYNAIRTNIQFSGAE--IKVLLITSVKPGEGKSTTSANIAIAFAQAGYKTLLIDGDMRNSVMSGTFKSQNKiTGLTNFL 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502643204  322 IGRARLDDVAQPWGNGNLDVITSGQVPPNPSELLGSRNMDELLDELHAKYDVVLIDTSPLLPVTDGAILARLVGGAVVVV 401
Cdd:TIGR01007  79 SGTTDLSDAICDTNIENLDVITAGPVPPNPTELLQSSNFKTLIETLRKRFDYIIIDTPPIGTVTDAAIIARACDASILVT 158

                         170       180       190
                  ....*....|....*....|....*....|....
gi 502643204  402 GAGTVHRQQVDGALQALDSVAARVLGVVVNRAPT 435
Cdd:TIGR01007 159 DAGKIKKREVKKAKEQLEQAGSNFLGVVLNKVDI 192
pepcterm_TyrKin TIGR03018
exopolysaccharide/PEP-CTERM locus tyrosine autokinase; Members of this protein family are ...
 231-431 1.17e-40

exopolysaccharide/PEP-CTERM locus tyrosine autokinase; Members of this protein family are related to a known protein-tyrosine autokinase and to numerous homologs from exopolysaccharide biosynthesis region proteins, many of which are designated as chain length determinants. Most members of this family contain a short region, immediately C-terminal to the region modeled here, with an abundance of Tyr residues. These C-terminal tyrosine residues are likely to be autophosphorylation sites. Some members of this family are fusion proteins.


Pssm-ID: 274392 [Multi-domain]  Cd Length: 207  Bit Score: 145.52  E-value: 1.17e-40
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502643204  231 LIVQESPHSLRSEAFRRLRTNLQFLEFD----RNQRAIVTTSALPGEGKTTTTINLAITLA-DAGQRVALVDADLRRPSI 305
Cdd:TIGR03018   1 LITPNSPRSRIAEEFRKIKRPLLANAFSaatkKNNNLIMVTSSLPGEGKSFTAINLAISLAqEYDKTVLLIDADLRRPSL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502643204  306 AKYMGLEGSVGLTTVLIGRAR-LDDVAQPWGNGNLDVITSGQVPPNPSELLGSRNMDELLDELHAKYD--VVLIDTSPLL 382
Cdd:TIGR03018  81 HRTLGLEAEPGLSDCLLDPVLdLADVLVPTNIGRLSLLPAGRRHPNPTELLASQRMRSLLHELARRYPdrIIIIDTPPLL 160

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*....
gi 502643204  383 PVTDGAILARLVGGAVVVVGAGTVHRQQVDGALQALDSvaARVLGVVVN 431
Cdd:TIGR03018 161 VFSEARALARLVGQIVLVVEEGRTTQEAVKEALSALES--CKVLGVVLN 207
eps_transp_fam TIGR01005
exopolysaccharide transport protein family; The model describes the exopolysaccharide ...
 159-432 3.81e-34

exopolysaccharide transport protein family; The model describes the exopolysaccharide transport protein family in bacteria. The transport protein is part of a large genetic locus which is associated with exopolysaccharide (EPS) biosynthesis. Detailed molecular characterization and gene fusion analysis revealed atleast seven gene products are involved in the overall regulation, which among other things, include exopolysaccharide biosynthesis, property of conferring virulence and exopolysaccharide export. [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]


Pssm-ID: 273391 [Multi-domain]  Cd Length: 764  Bit Score: 137.16  E-value: 3.81e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502643204  159 VRSAVAPTSPSSPNTTMNLALGLLVGLALGVGVAVLREVLNTKMRDVADVEAVTEASVLGAIPF---------------- 222
Cdd:TIGR01005 423 IDEAAVPEEPSKPKKLMTLALAAVLGMMLGGAAAAFLEALEGGFRDEGDIEEHLGHRSLATVPLldtqmdkkaqlthahf 502

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502643204  223 -----EPDAADSPL-------IVQESPHSLRSEAFRRLRTNLQFLEFDRNQRAIVTTSALPGEGKTTTTINLAITLADAG 290
Cdd:TIGR01005 503 gsvkrHDEAVDDTMpfqllarIVPDAPRSTFAEAFRNAKLACDFALADAENNLIAIAGALPDEGKSFIAANFAALIAAGG 582

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502643204  291 QRVALVDADLRRPSIAKYMGLEGSVGLTTVLIGRARLDDVAQPWGNGNLDVITSGQV---PPNPSELLGSRNMDELLDEL 367
Cdd:TIGR01005 583 KRTLLIDADIRKGGLHQMFGKAPKPGLLDLLAGEASIEAGIHRDQRPGLAFIAAGGAshfPHNPNELLANPAMAELIDNA 662

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 502643204  368 HAKYDVVLIDTSPLLPVTDGAILARLVGGAVVVVGAGTVHRQQVDGALQALDSVAARVLGVVVNR 432
Cdd:TIGR01005 663 RNAFDLVLVDLAALAAVADAAAFAALADGILFVTEFERSPLGEIRDLIHQEPHANSDVLGVIFNA 727
PRK11519 PRK11519
tyrosine-protein kinase Wzc;
229-431 1.20e-32

tyrosine-protein kinase Wzc;


Pssm-ID: 183173 [Multi-domain]  Cd Length: 719  Bit Score: 132.58  E-value: 1.20e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502643204 229 SPLIVQESPHSLRSEAFRRLRTNLQFLEFDRNQRAIVTTSALPGEGKTTTTINLAITLADAGQRVALVDADLRRPSIAKY 308
Cdd:PRK11519 494 SQLLAVGNPTDLAIEAIRSLRTSLHFAMMQAQNNVLMMTGVSPSIGKTFVCANLAAVISQTNKRVLLIDCDMRKGYTHEL 573

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502643204 309 MGLEGSVGLTTVLIGRARLDDVAQPWGNGNLDVITSGQVPPNPSELLGSRNMDELLDELHAKYDVVLIDTSPLLPVTDGA 388
Cdd:PRK11519 574 LGTNNVNGLSDILIGQGDITTAAKPTSIANFDLIPRGQVPPNPSELLMSERFAELVNWASKNYDLVLIDTPPILAVTDAA 653

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|...
gi 502643204 389 ILARLVGGAVVVVGAGTVHRQQVDGALQALDSVAARVLGVVVN 431
Cdd:PRK11519 654 IVGRHVGTTLMVARYAVNTLKEVETSLSRFEQNGIPVKGVILN 696
PRK09841 PRK09841
tyrosine-protein kinase;
228-431 1.20e-32

tyrosine-protein kinase;


Pssm-ID: 182106 [Multi-domain]  Cd Length: 726  Bit Score: 132.34  E-value: 1.20e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502643204 228 DSPLIVQESPHSLRSEAFRRLRTNLQFLEFDRNQRAIVTTSALPGEGKTTTTINLAITLADAGQRVALVDADLRRPSIAK 307
Cdd:PRK09841 498 NIPFLAVDNPADSAVEAVRALRTSLHFAMMETENNILMITGATPDSGKTFVSSTLAAVIAQSDQKVLFIDADLRRGYSHN 577

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502643204 308 YMGLEGSVGLTTVLIGRARLDDVAQPWGNGNLDVITSGQVPPNPSELLGSRNMDELLDELHAKYDVVLIDTSPLLPVTDG 387
Cdd:PRK09841 578 LFTVSNEHGLSEYLAGKDELNKVIQHFGKGGFDVITRGQVPPNPSELLMRDRMRQLLEWANDHYDLVIVDTPPMLAVSDA 657

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....
gi 502643204 388 AILARLVGGAVVVVGAGTVHRQQVDGALQALDSVAARVLGVVVN 431
Cdd:PRK09841 658 AVVGRSVGTSLLVARFGLNTAKEVSLSMQRLEQAGVNIKGAILN 701
polys_exp_MPA1 TIGR01006
polysaccharide export protein, MPA1 family, Gram-positive type; This family contains members ...
 1-221 1.50e-21

polysaccharide export protein, MPA1 family, Gram-positive type; This family contains members from Low GC Gram-positive bacteria; they are proposed to have a function in the export of complex polysaccharides. [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]


Pssm-ID: 130079 [Multi-domain]  Cd Length: 226  Bit Score: 93.29  E-value: 1.50e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502643204    1 MELADYLSLLRKRWLSITVLTVLGLVAGLAASV-LATPVFTARSQVFVSVRGSDTTSDLLQGSNFTVRQVRSYVQLVQTP 79
Cdd:TIGR01006   8 IDLLQLLKKLWKRKLLILIVALIFLIISFIYTFfIISPEYTSTTRIYVVNRNQDNKGLTAQDLQAGIQLVNDYKEIILSP 87

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502643204   80 RVLQPVIEELGLTDTPSQLAERVRAESPLDTVLINVTADDESAQFAADIANSVARSLSAVVQELEtpqgaaeSPVEISTV 159
Cdd:TIGR01006  88 DILDKVSKDLKLDLSPKELSSMVTVTNPTDTRLISISVKDKTPQDASKIANSLREVASKKIPKIT-------NVSDVTTL 160

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 502643204  160 RSAVAPTSPSSPNTTMNLALGLLVGLALGVGVAVLREVLNTKMRDVADVEAVTEASVLGAIP 221
Cdd:TIGR01006 161 EEAKPATTPSSPNPKRNLLIGFLLGLVVALIIVLLKELLDTRVKRPEDVEDVLGMTLLGIVP 222
FlhG COG0455
MinD-like ATPase FlhG/YlxH, activator of the FlhF-type GTPase [Cell cycle control, cell ...
 277-380 1.64e-19

MinD-like ATPase FlhG/YlxH, activator of the FlhF-type GTPase [Cell cycle control, cell division, chromosome partitioning, Cell motility];


Pssm-ID: 440223 [Multi-domain]  Cd Length: 230  Bit Score: 87.64  E-value: 1.64e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502643204 277 TTTINLAITLADAGQRVALVDADLRRPSIAKYMGLEGSVGLTTVLIGRARLDDVAQPwGNGNLDVITSGQVPPNPSELLG 356
Cdd:COG0455    1 TVAVNLAAALARLGKRVLLVDADLGLANLDVLLGLEPKATLADVLAGEADLEDAIVQ-GPGGLDVLPGGSGPAELAELDP 79

                         90       100
                 ....*....|....*....|....
gi 502643204 357 SRNMDELLDELHAKYDVVLIDTSP 380
Cdd:COG0455   80 EERLIRVLEELERFYDVVLVDTGA 103
ParA COG1192
ParA-like ATPase involved in chromosome/plasmid partitioning or cellulose biosynthesis protein ...
 272-391 1.26e-18

ParA-like ATPase involved in chromosome/plasmid partitioning or cellulose biosynthesis protein BcsQ [Cell cycle control, cell division, chromosome partitioning, Cell motility];


Pssm-ID: 440805 [Multi-domain]  Cd Length: 253  Bit Score: 85.29  E-value: 1.26e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502643204 272 GEGKTTTTINLAITLADAGQRVALVDADlrrP--SIAKYMGL---EGSVGLTTVLIGRARLDDVAQPWGNGNLDVItsgq 346
Cdd:COG1192   12 GVGKTTTAVNLAAALARRGKRVLLIDLD---PqgNLTSGLGLdpdDLDPTLYDLLLDDAPLEDAIVPTEIPGLDLI---- 84

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 502643204 347 vPPNPS------ELLGSRN----MDELLDELHAKYDVVLIDTSPLL-PVTDGAILA 391
Cdd:COG1192   85 -PANIDlagaeiELVSRPGrelrLKRALAPLADDYDYILIDCPPSLgLLTLNALAA 139
GumC COG3206
Exopolysaccharide export protein/domain GumC/Wzc1 [Cell wall/membrane/envelope biogenesis];
1-135 6.84e-18

Exopolysaccharide export protein/domain GumC/Wzc1 [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442439 [Multi-domain]  Cd Length: 687  Bit Score: 86.99  E-value: 6.84e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502643204   1 MELADYLSLLRKRWLSITVLTVLGLVAGLAASVLATPVFTARSQVFVSVRGSDTTSDLLQGSNFTVRQVRSYVQLVQTPR 80
Cdd:COG3206   15 IDLRDLLRILRRRKWLILLVFLLVLALALLYALLLPPVYEASATLLVEPQSSDVLLSGLSSLSASDSPLETQIEILKSRP 94

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 502643204  81 VLQPVIEELGLTDTP-----------SQLAERVRAESPLDTVLINVTADDESAQFAADIANSVARS 135
Cdd:COG3206   95 VLERVVDKLNLDEDPlgeeasreaaiERLRKNLTVEPVKGSNVIEISYTSPDPELAAAVANALAEA 160
MinD cd02036
septum site-determining protein MinD; Septum site-determining protein MinD is part of the ...
 262-380 2.44e-15

septum site-determining protein MinD; Septum site-determining protein MinD is part of the operon MinCDE that determines the site of the formation of a septum at mid-cell, an important part of bacterial cell division. MinC is a nonspecific inhibitor of the septum protein FtsZ. MinE is the supressor of MinC. MinD plays a pivotal role, selecting the mid-cell over other sites through the activation and regulation of MinC and MinE. MinD is a membrane-associated ATPase, related to nitrogenase iron protein.


Pssm-ID: 349756 [Multi-domain]  Cd Length: 236  Bit Score: 75.32  E-value: 2.44e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502643204 262 RAIVTTSALPGEGKTTTTINLAITLADAGQRVALVDAD--LRRPSIakYMGLEGSVGLTT--VLIGRARLDD--VAQPwG 335
Cdd:cd02036    1 RVIVITSGKGGVGKTTTTANLGVALAKLGKKVLLIDADigLRNLDL--ILGLENRIVYTLvdVLEGECRLEQalIKDK-R 77

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*
gi 502643204 336 NGNLDVITSGQvpPNPSELLGSRNMDELLDELHAKYDVVLIDtSP 380
Cdd:cd02036   78 WENLYLLPASQ--TRDKDALTPEKLEELVKELKDSFDFILID-SP 119
CpaE COG4963
Flp pilus assembly ATPase CpaE/TadZ, contains N-terminal REC/TadZ_N domain [Intracellular ...
 202-392 1.62e-13

Flp pilus assembly ATPase CpaE/TadZ, contains N-terminal REC/TadZ_N domain [Intracellular trafficking, secretion, and vesicular transport, Extracellular structures];


Pssm-ID: 443989 [Multi-domain]  Cd Length: 358  Bit Score: 72.07  E-value: 1.62e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502643204 202 MRDVADVEAVTEASVLGAIPFEPDAADSPLIVQESPhsLRSEAFRRLRTNLQFLEFDRNQRAIVTTSALPGEGKTTTTIN 281
Cdd:COG4963   45 GGAAAAAAAYLSAPTPNLILLEALSESAALLADVLP--LSPDELRAALARLLDPGAARRGRVIAVVGAKGGVGATTLAVN 122

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502643204 282 LAITLAD-AGQRVALVDADLRRPSIAKYMGLEGSVGLTTVLIGRARLDDVA-----QPWGNGnLDVItSGQVPPNPSELL 355
Cdd:COG4963  123 LAWALAReSGRRVLLVDLDLQFGDVALYLDLEPRRGLADALRNPDRLDETLldralTRHSSG-LSVL-AAPADLERAEEV 200

                        170       180       190
                 ....*....|....*....|....*....|....*..
gi 502643204 356 GSRNMDELLDELHAKYDVVLIDTSPLLPVTDGAILAR 392
Cdd:COG4963  201 SPEAVERLLDLLRRHFDYVVVDLPRGLNPWTLAALEA 237
AAA_31 pfam13614
AAA domain; This family includes a wide variety of AAA domains including some that have lost ...
 272-382 1.86e-13

AAA domain; This family includes a wide variety of AAA domains including some that have lost essential nucleotide binding residues in the P-loop.


Pssm-ID: 433350 [Multi-domain]  Cd Length: 177  Bit Score: 68.76  E-value: 1.86e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502643204  272 GEGKTTTTINLAITLADAGQRVALVDADlrrPSIA--KYMGLEGSVGLTT---VLIGRARLDDVAQPWGNGNLDVITSG- 345
Cdd:pfam13614  12 GVGKTTTSVNLAAALAKKGKKVLLIDLD---PQGNatSGLGIDKNNVEKTiyeLLIGECNIEEAIIKTVIENLDLIPSNi 88

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 502643204  346 ---QVPPNPSELLGSRN-MDELLDELHAKYDVVLIDTSPLL 382
Cdd:pfam13614  89 dlaGAEIELIGIENRENiLKEALEPVKDNYDYIIIDCPPSL 129
FlhG-like cd02038
MinD-like ATPase FlhG; FlhG is a member of the SIMIBI superfamily. FlhG (also known as YlxH) ...
 262-380 2.93e-13

MinD-like ATPase FlhG; FlhG is a member of the SIMIBI superfamily. FlhG (also known as YlxH) is a major determinant for a variety of flagellation patterns. It effects location and number of bacterial flagella during C-ring assembly.


Pssm-ID: 349758 [Multi-domain]  Cd Length: 230  Bit Score: 69.14  E-value: 2.93e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502643204 262 RAIVTTSALPGEGKTTTTINLAITLADAGQRVALVDADLRRPSIAKYMGLEGSVGLTTVLIGRARLDDVAQPwGNGNLDV 341
Cdd:cd02038    1 RIIAVTSGKGGVGKTNVSANLALALSKLGKRVLLLDADLGLANLDILLGLAPKKTLGDVLKGRVSLEDIIVE-GPEGLDI 79

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|.
gi 502643204 342 ITSGQVPPNPSELLGSRNMD--ELLDELHAKYDVVLIDTSP 380
Cdd:cd02038   80 IPGGSGMEELANLDPEQKAKliEELSSLESNYDYLLIDTGA 120
CbiA pfam01656
CobQ/CobB/MinD/ParA nucleotide binding domain; This family consists of various cobyrinic acid ...
 272-380 2.83e-12

CobQ/CobB/MinD/ParA nucleotide binding domain; This family consists of various cobyrinic acid a,c-diamide synthases. These include CbiA and CbiP from S.typhimurium, and CobQ from R. capsulatus. These amidases catalyze amidations to various side chains of hydrogenobyrinic acid or cobyrinic acid a,c-diamide in the biosynthesis of cobalamin (vitamin B12) from uroporphyrinogen III. Vitamin B12 is an important cofactor and an essential nutrient for many plants and animals and is primarily produced by bacteria. The family also contains dethiobiotin synthetases as well as the plasmid partitioning proteins of the MinD/ParA family.


Pssm-ID: 426369 [Multi-domain]  Cd Length: 228  Bit Score: 66.22  E-value: 2.83e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502643204  272 GEGKTTTTINLAITLADAGQRVALVDADLRRPSiAKYMGLEGSV-----GLTTVLIGRARLDDVAQ--PWGNGNLDVITS 344
Cdd:pfam01656   9 GVGKTTLAANLARALARRGLRVLLIDLDPQSNN-SSVEGLEGDIapalqALAEGLKGRVNLDPILLkeKSDEGGLDLIPG 87

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 502643204  345 GQVPPNPSELLGSR----NMDELLDELHAKYDVVLIDTSP 380
Cdd:pfam01656  88 NIDLEKFEKELLGPrkeeRLREALEALKEDYDYVIIDGAP 127
minD CHL00175
septum-site determining protein; Validated
 262-377 5.02e-12

septum-site determining protein; Validated


Pssm-ID: 214385 [Multi-domain]  Cd Length: 281  Bit Score: 66.33  E-value: 5.02e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502643204 262 RAIVTTSALPGEGKTTTTINLAITLADAGQRVALVDADLRRPSIAKYMGLEGSVGLTT--VLIGRARLDDVA---QPWGN 336
Cdd:CHL00175  16 RIIVITSGKGGVGKTTTTANLGMSIARLGYRVALIDADIGLRNLDLLLGLENRVLYTAmdVLEGECRLDQALirdKRWKN 95

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|..
gi 502643204 337 GNLDVITSGQVPPNpselLGSRNMDELLDELHAK-YDVVLID 377
Cdd:CHL00175  96 LSLLAISKNRQRYN----VTRKNMNMLVDSLKNRgYDYILID 133
GumC COG3206
Exopolysaccharide export protein/domain GumC/Wzc1 [Cell wall/membrane/envelope biogenesis];
126-431 9.18e-12

Exopolysaccharide export protein/domain GumC/Wzc1 [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442439 [Multi-domain]  Cd Length: 687  Bit Score: 67.73  E-value: 9.18e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502643204 126 ADIANSVARSLSAVVQELETPQGAAESPVEIstVRSAVAPTSPSSPNTTMNLALGLLVGLALGVGVAVLREVLNTKMRDV 205
Cdd:COG3206  360 VEVARELYESLLQRLEEARLAEALTVGNVRV--IDPAVVPLKPVSPKKLLILALGLLLGLLLGLGLALLLELLDRTIEEE 437

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502643204 206 ADVEAVTEASVLGAIPFEPDAADSPLIVQESPHSLRSEAFRRLRTNLQFLEFDRNQRAIVTTSALPGEGKTTTTINLAIT 285
Cdd:COG3206  438 LELLLLLGLPLLGPLPPLKSKRERRRARLALLLLAAALAALLALLLALLLLLLLLLLLLLVSSSSGGGSSSTSSALAAAS 517

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502643204 286 LADAGQRVALVDADLRRPSIA-------KYMGLEGSVGLTTVLIGRARLDDVAQPWGNGNLDVITSGQVPPNPSELLGSR 358
Cdd:COG3206  518 AAAAAAAALLLLLLLLLLLDLlllllllLLLLLLLLGGLLLLLLLLLLLLLLLLLLLLLLLLLLPPPLLLPLLLLLLLLL 597

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 502643204 359 NMDELLDELHAKYDVVLIDTSPLLPVTDGAILARLVGGAVVVVGAGTVHRQQVDGALQALDSVAARVLGVVVN 431
Cdd:COG3206  598 LLLLLLLLLLLSDDLILDLVPLLAALLAAAVLAVLVVVLLLVVALVALARLALLAAALLLLLVLVVVGGVVLG 670
minD_arch TIGR01969
cell division ATPase MinD, archaeal; This model represents the archaeal branch of the MinD ...
 262-377 3.03e-11

cell division ATPase MinD, archaeal; This model represents the archaeal branch of the MinD family. MinD, a weak ATPase, works in bacteria with MinC as a generalized cell division inhibitor and, through interaction with MinE, prevents septum placement inappropriate sites. Often several members of this family are found in archaeal genomes, and the function is uncharacterized. More distantly related proteins ParA chromosome partitioning proteins. The exact roles of the various archaeal MinD homologs are unknown.


Pssm-ID: 131024 [Multi-domain]  Cd Length: 251  Bit Score: 63.60  E-value: 3.03e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502643204  262 RAIVTTSALPGEGKTTTTINLAITLADAGQRVALVDADLRRPSIAKYMGLEG-SVGLTTVLIGRARLDDvAQPWGNGNLD 340
Cdd:TIGR01969   1 RIITIASGKGGTGKTTITANLGVALAKLGKKVLALDADITMANLELILGMEDkPVTLHDVLAGEADIKD-AIYEGPFGVK 79

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|..
gi 502643204  341 VItsgqvpPNPSELLGSRNMD-----ELLDELHAKYDVVLID 377
Cdd:TIGR01969  80 VI------PAGVSLEGLRKADpdkleDVLKEIIDDTDFLLID 115
Mrp_NBP35 cd02037
Mrp/NBP35 ATP-binding protein family; Mrp/NBP35 ATP-binding family protein are typically ...
 264-390 1.01e-09

Mrp/NBP35 ATP-binding protein family; Mrp/NBP35 ATP-binding family protein are typically iron-sulfur (FeS) cluster scaffolds that function to assemble nascent FeS clusters for transfer to FeS-requiring enzymes. Members include the eukaryotic nucleotide-binding protein 1 (NUBP1) which is a component of the cytosolic iron-sulfur (Fe/S) protein assembly (CIA) machinery and the archael [NiFe] hydrogenase maturation protein HypB which is required for nickel insertion into [NiFe] hydrogenase.


Pssm-ID: 349757 [Multi-domain]  Cd Length: 213  Bit Score: 58.67  E-value: 1.01e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502643204 264 IVTTSALPGEGKTTTTINLAITLADAGQRVALVDADLRRPSIAKYMGLEGSvgltTVLIGRARLddvaQPWGNGNLDVIT 343
Cdd:cd02037    3 IAVLSGKGGVGKSTVAVNLALALAKKGYKVGLLDADIYGPSIPRLLGVEGK----PLHQSEEGI----VPVEVGGIKVMS 74

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 502643204 344 SGQ-VPPN-------PS------ELLGSRNMDELldelhakyDVVLIDTSP-----------LLPVtDGAIL 390
Cdd:cd02037   75 IGFlLPEDdaviwrgPMksgaikQFLKDVDWGEL--------DYLIIDLPPgtgdehlslvqLIPI-DGAVV 137
ParA pfam10609
NUBPL iron-transfer P-loop NTPase; This family contains ATPases involved in plasmid ...
 272-313 1.56e-09

NUBPL iron-transfer P-loop NTPase; This family contains ATPases involved in plasmid partitioning. It also contains the cytosolic Fe-S cluster assembling factor NBP35 which is required for biogenesis and export of both ribosomal subunits.


Pssm-ID: 431392 [Multi-domain]  Cd Length: 246  Bit Score: 58.62  E-value: 1.56e-09
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 502643204  272 GEGKTTTTINLAITLADAGQRVALVDADLRRPSIAKYMGLEG 313
Cdd:pfam10609  14 GVGKSTVAVNLALALARLGYKVGLLDADIYGPSIPRMLGLEG 55
Wzz pfam02706
Chain length determinant protein; This family includes proteins involved in lipopolysaccharide ...
 1-88 2.14e-08

Chain length determinant protein; This family includes proteins involved in lipopolysaccharide (lps) biosynthesis. This family comprises the whole length of chain length determinant protein (or wzz protein) that confers a modal distribution of chain length on the O-antigen component of lps. This region is also found as part of bacterial tyrosine kinases.


Pssm-ID: 460658 [Multi-domain]  Cd Length: 90  Bit Score: 51.52  E-value: 2.14e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502643204    1 MELADYLSLLRKRWLSITVLTVLGLVAGLAASVLATPVFTARSQVFV----SVRGSDTTSDLLQGSNFtvrqVRSYVQLV 76
Cdd:pfam02706   3 IDLIELLGVLWKRKKLIILVTLLFTLLAAAYAFLATPKYTATAQILVpqkkGEAGSLLGSDLQAGLQL----ASTEIEIL 78

                          90
                  ....*....|..
gi 502643204   77 QTPRVLQPVIEE 88
Cdd:pfam02706  79 KSRDVLEKVIDE 90
ParAB_family cd02042
partition proteins ParAB family; ParA and ParB of Caulobacter crescentus belong to a conserved ...
 272-299 2.11e-07

partition proteins ParAB family; ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the initiation of DNA replication. ParB regulates the ParA ATPase activity by promoting nucleotide exchange in a fashion reminiscent of the exchange factors of eukaryotic G proteins. ADP-bound ParA binds single-stranded DNA, whereas the ATP-bound form dissociates ParB from its DNA binding sites. Increasing the fraction of ParA-ADP in the cell inhibits cell division, suggesting that this simple nucleotide switch may regulate cytokinesis. ParA shares sequence similarity to a conserved and widespread family of ATPases which includes the repA protein of the repABC operon in Rhizobium etli symbiotic plasmid. This operon is involved in the plasmid replication and partition.


Pssm-ID: 349760 [Multi-domain]  Cd Length: 130  Bit Score: 49.85  E-value: 2.11e-07
                         10        20
                 ....*....|....*....|....*...
gi 502643204 272 GEGKTTTTINLAITLADAGQRVALVDAD 299
Cdd:cd02042   11 GVGKTTLAVNLAAALALRGKRVLLIDLD 38
MipZ pfam09140
ATPase MipZ; MipZ is an ATPase that forms a complex with the chromosome partitioning protein ...
 272-378 2.90e-07

ATPase MipZ; MipZ is an ATPase that forms a complex with the chromosome partitioning protein ParB near the chromosomal origin of replication. It is responsible for the temporal and spatial regulation of FtsZ ring formation.


Pssm-ID: 401181 [Multi-domain]  Cd Length: 262  Bit Score: 52.07  E-value: 2.90e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502643204  272 GEGKTTTTINLAITLADAGQRVALVDADLRRPSIAKYMGLEgsvglttvligRARLD----DVAQPwGNGNLDVITSGQV 347
Cdd:pfam09140  11 GSGKSTTAVHVAVALLYKGARVAAIDLDLRQRTFHRYFENR-----------SATADrtglSLPTP-EHLNLPDNDVAEV 78

                          90       100       110
                  ....*....|....*....|....*....|.
gi 502643204  348 PPNPSEllGSRNMDELLDELHAKYDVVLIDT 378
Cdd:pfam09140  79 PDGENI--DDARLEEAFADLEARCDFIVIDT 107
SIMIBI cd01983
SIMIBI (signal recognition particle, MinD and BioD)-class NTPases; SIMIBI (after signal ...
 262-299 2.89e-06

SIMIBI (signal recognition particle, MinD and BioD)-class NTPases; SIMIBI (after signal recognition particle, MinD, and BioD), consists of signal recognition particle (SRP) GTPases, the assemblage of MinD-like ATPases, which are involved in protein localization, chromosome partitioning, and membrane transport, and a group of metabolic enzymes with kinase or related phosphate transferase activity. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion.


Pssm-ID: 349751 [Multi-domain]  Cd Length: 107  Bit Score: 45.88  E-value: 2.89e-06
                         10        20        30
                 ....*....|....*....|....*....|....*...
gi 502643204 262 RAIVTTSALPGEGKTTTTINLAITLADAGQRVALVDAD 299
Cdd:cd01983    1 RVIAVTGGKGGVGKTTLAAALAVALAAKGYKVLLIDLD 38
ParA_partition NF041546
ParA family partition ATPase;
272-299 1.36e-05

ParA family partition ATPase;


Pssm-ID: 469431 [Multi-domain]  Cd Length: 202  Bit Score: 46.01  E-value: 1.36e-05
                         10        20
                 ....*....|....*....|....*...
gi 502643204 272 GEGKTTTTINLAITLADAGQRVALVDAD 299
Cdd:NF041546  10 GVGKTTLATHLAAALARRGYRVLLVDAD 37
PRK11670 PRK11670
iron-sulfur cluster carrier protein ApbC;
264-310 1.64e-05

iron-sulfur cluster carrier protein ApbC;


Pssm-ID: 183270 [Multi-domain]  Cd Length: 369  Bit Score: 46.96  E-value: 1.64e-05
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*..
gi 502643204 264 IVTTSALPGEGKTTTTINLAITLADAGQRVALVDADLRRPSIAKYMG 310
Cdd:PRK11670 110 IAVSSGKGGVGKSSTAVNLALALAAEGAKVGILDADIYGPSIPTMLG 156
CpaE-like cd03111
pilus assembly ATPase CpaE; This protein family consists of proteins similar to the cpaE ...
 268-390 6.68e-05

pilus assembly ATPase CpaE; This protein family consists of proteins similar to the cpaE protein of the Caulobacter pilus assembly and the orf4 protein of Actinobacillus pilus formation gene cluster. The function of these proteins are unkown. The Caulobacter pilus assembly contains 7 genes: pilA, cpaA, cpaB, cpaC, cpaD, cpaE and cpaF. These genes are clustered together on chromosome.


Pssm-ID: 349765 [Multi-domain]  Cd Length: 235  Bit Score: 44.58  E-value: 6.68e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502643204 268 SALPGEGKTTTTINLAITLA-DAGQRVALVDADLRRPSIAKYMGLEGSVGLTTVLIGRARLDDVAQpwgNGNLDVITSG- 345
Cdd:cd03111    7 GAKGGVGASTLAVNLAQELAqRAKDKVLLIDLDLPFGDLGLYLNLRPDYDLADVIQNLDRLDRTLL---DSAVTRHSSGl 83

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|
gi 502643204 346 QVPPNPSELLGSRNM-----DELLDELHAKYDVVLIDTSPLLPVTDGAIL 390
Cdd:cd03111   84 SLLPAPQELEDLEALgaeqvDKLLQVLRAFYDHIIVDLGHFLDEVTLAVL 133
MIS1 COG2759
Formyltetrahydrofolate synthetase [Nucleotide transport and metabolism];
263-313 6.43e-04

Formyltetrahydrofolate synthetase [Nucleotide transport and metabolism];


Pssm-ID: 442046  Cd Length: 556  Bit Score: 42.33  E-value: 6.43e-04
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|.
gi 502643204 263 AIVTTSAlpGEGKTTTTINLAITLADAGQRVALVdadLRRPSIAKYMGLEG 313
Cdd:COG2759   61 AITPTPA--GEGKTTTTVGLGQALNRLGKKAIVA---LREPSLGPVFGIKG 106
FTHFS cd00477
formyltetrahydrofolate synthetase; Formyltetrahydrofolate synthetase (FTHFS) catalyzes the ...
 252-314 1.27e-03

formyltetrahydrofolate synthetase; Formyltetrahydrofolate synthetase (FTHFS) catalyzes the ATP-dependent activation of formate ion via its addition to the N10 position of tetrahydrofolate. FTHFS is a highly expressed key enzyme in both the Wood-Ljungdahl pathway of autotrophic CO2 fixation (acetogenesis) and the glycine synthase/reductase pathways of purinolysis. The key physiological role of this enzyme in acetogens is to catalyze the formylation of tetrahydrofolate, an initial step in the reduction of carbon dioxide and other one-carbon precursors to acetate. In purinolytic organisms, the enzymatic reaction is reversed, liberating formate from 10-formyltetrahydrofolate with concurrent production of ATP.


Pssm-ID: 349750  Cd Length: 540  Bit Score: 41.37  E-value: 1.27e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 502643204 252 LQFLEFDRNQRAIVTTSALP---GEGKTTTTINLAITLADAGQRVAlvdADLRRPSIAKYMGLEGS 314
Cdd:cd00477   30 LDRLKDRPDGKYILVTAITPtplGEGKSTTTIGLAQALGALGKKAI---AALRQPSLGPTFGIKGG 92
PRK13505 PRK13505
formate--tetrahydrofolate ligase; Provisional
 263-313 1.88e-03

formate--tetrahydrofolate ligase; Provisional


Pssm-ID: 237403  Cd Length: 557  Bit Score: 40.94  E-value: 1.88e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|.
gi 502643204 263 AIVTTSAlpGEGKTTTTINLAITLADAGQRVALVdadLRRPSIAKYMGLEG 313
Cdd:PRK13505  62 AINPTPA--GEGKSTVTVGLGDALNKIGKKTVIA---LREPSLGPVFGIKG 107
SRP_G cd18539
GTPase domain of signal recognition particle protein; The signal recognition particle (SRP) ...
 263-303 3.71e-03

GTPase domain of signal recognition particle protein; The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal signal sequences of newly synthesized polypeptides at the ribosome. The SRP-polypeptide complex is then targeted to the membrane by an interaction between SRP and its cognated receptor (SR). In mammals, SRP consists of six protein subunits and a 7SL RNA. One of these subunits is a 54 kd protein (SRP54), which is a GTP-binding protein that interacts with the signal sequence when it emerges from the ribosome. SRP54 is a multidomain protein that consists of an N-terminal domain, followed by a central G (GTPase) domain and a C-terminal M domain.


Pssm-ID: 349786  Cd Length: 193  Bit Score: 38.73  E-value: 3.71e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|.
gi 502643204 263 AIVTTSALPGEGKTTTTINLAITLADAGQRVALVDADLRRP 303
Cdd:cd18539    1 TVILLVGLQGSGKTTTAAKLALYLKKKGKKVLLVAADVYRP 41
FTHFS pfam01268
Formate--tetrahydrofolate ligase;
263-313 6.25e-03

Formate--tetrahydrofolate ligase;


Pssm-ID: 460143  Cd Length: 555  Bit Score: 39.23  E-value: 6.25e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|.
gi 502643204  263 AIVTTSAlpGEGKTTTTINLAITLADAGQRVALVdadLRRPSIAKYMGLEG 313
Cdd:pfam01268  60 AITPTPA--GEGKTTTTIGLAQALNRLGKKAIAA---LREPSLGPVFGIKG 105
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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