FhaA, N-terminal domain; This domain can be found at the N terminus of FHA domain-containing protein Fha from Mycobacterium tuberculosis. The FHA (Fork Head Associated) domain is a phosphopeptide- specific binding domain that enables the protein to specifically bind to sequences containing phosphothreonine. FhaA is one of the major substrates of Ser/Thr protein kinases (STPK) and plays a role in the regulation of cell growth and peptidoglycan synthesis by binding to MviN. It may inhibit the late stages of peptidoglycan synthesis.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502677987    4 FDRFEKSVEGAMNSVFAKFGSKDLQPVDFSSALEREIDAEAMPIGRDHTVAPNEYRFKLSTPDFDHIEQWGsEALANELA 83
Cdd:pfam12401   1 LDRFERRLERAVEGAFARVFGGEVQPVEIAKALRREMDDNARVVSGGRVLAPNVYTVELSPDDYERLAPWG-DTLADELA 79

                          90       100       110
                  ....*....|....*....|....*....|...
gi 502677987   84 DNLTQYAKSQHYAFVGPVVVIFEEDLELTKGNF 116
Cdd:pfam12401  80 DYLAEHAREQGYTFVGPVVVRFEEDESLHTGQF 112

FhaA, N-terminal domain; This domain can be found at the N terminus of FHA domain-containing protein Fha from Mycobacterium tuberculosis. The FHA (Fork Head Associated) domain is a phosphopeptide- specific binding domain that enables the protein to specifically bind to sequences containing phosphothreonine. FhaA is one of the major substrates of Ser/Thr protein kinases (STPK) and plays a role in the regulation of cell growth and peptidoglycan synthesis by binding to MviN. It may inhibit the late stages of peptidoglycan synthesis.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502677987    4 FDRFEKSVEGAMNSVFAKFGSKDLQPVDFSSALEREIDAEAMPIGRDHTVAPNEYRFKLSTPDFDHIEQWGsEALANELA 83
Cdd:pfam12401   1 LDRFERRLERAVEGAFARVFGGEVQPVEIAKALRREMDDNARVVSGGRVLAPNVYTVELSPDDYERLAPWG-DTLADELA 79

                          90       100       110
                  ....*....|....*....|....*....|...
gi 502677987   84 DNLTQYAKSQHYAFVGPVVVIFEEDLELTKGNF 116
Cdd:pfam12401  80 DYLAEHAREQGYTFVGPVVVRFEEDESLHTGQF 112

forkhead associated (FHA) domain superfamily; Forkhead-associated (FHA) domains are small phosphopeptide recognition modules mostly found in eubacteria and eukaryotes. It is about 95-120 residues long that fold into an 11-stranded beta-sandwich. FHA domains can mediate the recognition of phosphorylated and non-phosphorylated substrates, as well as protein oligomerization. They specifically recognize threonine phosphorylation (pThr) accompanying activation of protein serine/threonine kinases. FHA domains show diverse ligand specificity. They may recognize the pTXXD motif, the pTXXI/L motif, and TQ clusters (singly and multiply phosphorylated). In eukaryotes, FHA superfamily members include forkhead-type transcription factors, as well as other signaling proteins, such as many regulatory proteins, kinases, phosphatases, motor proteins called kinesins, and metabolic enzymes. Many of them localize to the nucleus, where they participate in establishing or maintaining cell cycle checkpoints, DNA repair, or transcriptional regulation. FHA domains play important roles in human diseases, particularly in relation to DNA damage responses and cancers. In bacteria, FHA domain-containing proteins may participate in injection of viral proteins into host cells, transmembrane transporters, and cell division. FHA domain-containing proteins rarely include more than one copy of the domain. The only exception in eukaryotes is the checkpoint kinase Rad53 from Saccharomyces cerevisiae, which harbors two FHA domains (FHA1 and FHA2) flanking a central kinase domain. The two FHA domains recognize different phosphorylated targets and function independently from one another. In contrast, Mycobacterium tuberculosis ABC transporter Rv1747 contains two FHA domains but only one of them is essential for protein function.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502677987 146 GNQYLLTKDRTILGRGSGCDIVIDDPGISRHHLGIDITPDGVIARDLGSTNGTYVEGHQV-PAATLVDGNTITIGRTRIL 224
Cdd:cd00060   11 GREFPLTKGVVTIGRSPDCDIVLDDPSVSRRHARIEVDGGGVYLEDLGSTNGTFVNGKRItPPVPLQDGDVIRLGDTTFR 90

                 .
gi 502677987 225 Y 225
Cdd:cd00060   91 F 91

Forkhead associated domain; Found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain.

                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|..
gi 502677987   156 TILGRGS-GCDIVIDDPGISRHHLGIDITPDG-VIARDLGSTNGTYVEGHQV 205
Cdd:smart00240   1 VTIGRSSeDCDIQLDGPSISRRHAVIVYDGGGrFYLIDLGSTNGTFVNGKRI 52

FhaA, N-terminal domain; This domain can be found at the N terminus of FHA domain-containing protein Fha from Mycobacterium tuberculosis. The FHA (Fork Head Associated) domain is a phosphopeptide- specific binding domain that enables the protein to specifically bind to sequences containing phosphothreonine. FhaA is one of the major substrates of Ser/Thr protein kinases (STPK) and plays a role in the regulation of cell growth and peptidoglycan synthesis by binding to MviN. It may inhibit the late stages of peptidoglycan synthesis.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502677987    4 FDRFEKSVEGAMNSVFAKFGSKDLQPVDFSSALEREIDAEAMPIGRDHTVAPNEYRFKLSTPDFDHIEQWGsEALANELA 83
Cdd:pfam12401   1 LDRFERRLERAVEGAFARVFGGEVQPVEIAKALRREMDDNARVVSGGRVLAPNVYTVELSPDDYERLAPWG-DTLADELA 79

                          90       100       110
                  ....*....|....*....|....*....|...
gi 502677987   84 DNLTQYAKSQHYAFVGPVVVIFEEDLELTKGNF 116
Cdd:pfam12401  80 DYLAEHAREQGYTFVGPVVVRFEEDESLHTGQF 112

forkhead associated (FHA) domain superfamily; Forkhead-associated (FHA) domains are small phosphopeptide recognition modules mostly found in eubacteria and eukaryotes. It is about 95-120 residues long that fold into an 11-stranded beta-sandwich. FHA domains can mediate the recognition of phosphorylated and non-phosphorylated substrates, as well as protein oligomerization. They specifically recognize threonine phosphorylation (pThr) accompanying activation of protein serine/threonine kinases. FHA domains show diverse ligand specificity. They may recognize the pTXXD motif, the pTXXI/L motif, and TQ clusters (singly and multiply phosphorylated). In eukaryotes, FHA superfamily members include forkhead-type transcription factors, as well as other signaling proteins, such as many regulatory proteins, kinases, phosphatases, motor proteins called kinesins, and metabolic enzymes. Many of them localize to the nucleus, where they participate in establishing or maintaining cell cycle checkpoints, DNA repair, or transcriptional regulation. FHA domains play important roles in human diseases, particularly in relation to DNA damage responses and cancers. In bacteria, FHA domain-containing proteins may participate in injection of viral proteins into host cells, transmembrane transporters, and cell division. FHA domain-containing proteins rarely include more than one copy of the domain. The only exception in eukaryotes is the checkpoint kinase Rad53 from Saccharomyces cerevisiae, which harbors two FHA domains (FHA1 and FHA2) flanking a central kinase domain. The two FHA domains recognize different phosphorylated targets and function independently from one another. In contrast, Mycobacterium tuberculosis ABC transporter Rv1747 contains two FHA domains but only one of them is essential for protein function.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502677987 146 GNQYLLTKDRTILGRGSGCDIVIDDPGISRHHLGIDITPDGVIARDLGSTNGTYVEGHQV-PAATLVDGNTITIGRTRIL 224
Cdd:cd00060   11 GREFPLTKGVVTIGRSPDCDIVLDDPSVSRRHARIEVDGGGVYLEDLGSTNGTFVNGKRItPPVPLQDGDVIRLGDTTFR 90

                 .
gi 502677987 225 Y 225
Cdd:cd00060   91 F 91

forkhead associated (FHA) domain found in Bdellovibrio bacteriovorus GGDEF domain protein DgcB and similar proteins; DgcB is a GGDEF enzyme that produces cyclic-di-GMP in response to an unknown stimulus. It appends the C-terminal GGDEF enzymatic domain with an N-terminal forkhead-associated (FHA) domain that acts as a consensus phosphopeptide sensor. The GGDEF and sensory FHA domains form an asymmetrical dimer.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502677987 143 EINGNQYLLTKDRTILGRGSGCDIVIDDPGISRHHLGIDITPDGVIARDLGSTNGTYVEGHQVP---AATLVDGNTITIG 219
Cdd:cd22682    9 PGVGKQFPITESTIVIGRSVESQVQIDDDSVSRYHAKLAVNPSAVSIIDLGSTNGTIVNGKKIPklaSCDLQNGDQIKIG 88

                 ..
gi 502677987 220 RT 221
Cdd:cd22682   89 NT 90

FHA domain; The FHA (Forkhead-associated) domain is a phosphopeptide binding motif.

                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 502677987  156 TILGRGSGCDIVIDDPGISRHHLGIDITPDG-VIARDLGSTNGTYVEGHQVP--AATLVDGNTITI 218
Cdd:pfam00498   1 VTIGRSPDCDIVLDDPSVSRRHAEIRYDGGGrFYLEDLGSTNGTFVNGQRLGpePVRLKDGDVIRL 66

forkhead associated (FHA) domain found in Myxococcus xanthus EspA and similar proteins; EspA is a histidine protein kinase with a fork head-associated (FHA) domain at the N-terminus and a receiver domain at the C-terminus. It functions as an inhibitor of sporulation during early fruiting body development while cells are aggregating into raised mounds. EspA is part of a two-component signal transduction system that regulates the timing of sporulation initiation. The FHA domain is a small phosphopeptide recognition module.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502677987 139 HPMLEINGNQYLLTKDRTILGRGSGCDIVIDDPGISRHHLGIDITPDGVIARDLGSTNGTYVEGHQVPAATLVDGNTITI 218
Cdd:cd22698    6 EQKGSEEGKDYELDQDEFTIGRSSNNDIRLNDHSVSRHHARIVRQGDKCNLTDLGSTNGTFLNGIRVGTHELKHGDRIQL 85

                 ...
gi 502677987 219 GRT 221
Cdd:cd22698   86 GET 88

forkhead associated (FHA) domain found in Arabidopsis thaliana Protein PARALLEL SPINDLE 1 (PS1) and similar proteins; PS1 is an FHA domain-containing protein required for normal spindle orientation at male meiosis II and normal formation of tetrad of microspores. It is not involved in female meiosis. Mutations in PS1 lead to the production of diploid pollen grains. The FHA domain is a small phosphopeptide recognition module.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502677987 154 DRTILGRGSGCDIVIDDPGISRHHLGIDITPD--GVIARDLGSTNGTYVEGHQVPAATLV---DGNTITIG---RTRILY 225
Cdd:cd22691   29 DILVVGRHPDCDIVLDHPSISRFHLEIRIIPSrrKITLTDLSSVHGTWVNGQRIEPGVPVeleEGDTVRLGastRVYRLH 108

                 ...
gi 502677987 226 WAS 228
Cdd:cd22691  109 WIP 111

forkhead associated (FHA) domain found in Sulfolobus Acidocaldarius FHA domain-containing protein ArnA and similar proteins; ArnA is an FHA domain-containing protein from Sulfolobus acidocaldarius that was shown to strongly interact with ArnB, a von Willebrand domain-containing protein. They act synergistically and negatively to modulate motility. ArnA is involved in regulating archaella expression in S. acidocaldarius. The FHA domain is a small phosphopeptide recognition module.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502677987 145 NGNQYLLTKDRTILGRGSGCDIVIDDPGISRHHLGIDITPDGVIARDLGSTNGTYV-EGHQV-PAATLVDGNTITIGRTR 222
Cdd:cd22680   12 TGKKFPFDFSSVSIGRDPENVIVIPDPFVSRNHARITVDSNEIYIEDLGSTNGTFVnDFKRIkGPAKLHPNDIIKLGRTT 91

                 ..
gi 502677987 223 IL 224
Cdd:cd22680   92 VL 93

forkhead associated (FHA) domain found in Mycobacterium tuberculosis FHA domain-containing protein FhaA and similar proteins; FhaA regulates cell growth and peptidoglycan synthesis by binding to MviN. It may inhibit the late stages of peptidoglycan synthesis. It contains an FHA domain, which is a small phosphopeptide recognition module.

                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 502677987 149 YLLTKDRTILGRGSGCDIVIDDPGISRHHLGIDITPDGVIARDLGSTNGTYVEGHQV-PAATLVDGNTITIGRTRI 223
Cdd:cd22668   13 YQLREGSNIIGRGSDADFRLPDTGVSRRHAEIRWDGQVAHLTDLGSTNGTTVNNAPVtPEWRLADGDVITLGHSEI 88

Forkhead associated domain; Found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain.

                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|..
gi 502677987   156 TILGRGS-GCDIVIDDPGISRHHLGIDITPDG-VIARDLGSTNGTYVEGHQV 205
Cdd:smart00240   1 VTIGRSSeDCDIQLDGPSISRRHAVIVYDGGGrFYLIDLGSTNGTFVNGKRI 52

forkhead associated (FHA) domain found in Chlamydia trachomatis Ct664 protein and similar proteins; This subfamily corresponds to a group of uncharacterized FHA domain-containing proteins which show high sequence similarity with Chlamydia trachomatis Ct664 protein. Ct664 situates within the type III secretion system cluster that also encodes an STPK (CT673 in C. trachomatis), suggesting a role of CT664 in the chlamydial type III secretion system by mediating phosphorylation-dependent protein-protein interactions. The FHA domain is a small phosphopeptide recognition module.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502677987 145 NGNQYLLTKDRT-ILGRGSG-CDIVIDDPGISRHHLGIDITPDG-VIARDLGSTNGTYVEGHQVPAATLVDGN-TITIGR 220
Cdd:cd22696   11 NGAEFFLESGKTyFIGKDPTvCDIVLQDPSISRQHARLSIDQDNrVFIEDLSSKNGVLVNGKPIEGKEEISGSdVISLGT 90

                 ....
gi 502677987 221 TRIL 224
Cdd:cd22696   91 TSFL 94

forkhead associated (FHA) domain found in Mycobacterium tuberculosis glycogen accumulation regulator GarA and similar proteins; GarA is an FHA domain-containing protein involved in the regulation of glutamate metabolism. It acts as a phosphorylation-dependent ON/OFF molecular switch that modulates the activities of KGD, GDH and GltB. Its FHA domain has dual specificity. It binds to both phosphorylated upstream partners, such as the kinases PknB and PknG, and nonphosphorylated downstream partners, such as the 2-oxoglutarate decarboxylase KGD. The FHA domain is a small phosphopeptide recognition module.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502677987 146 GNQYLLTKDRTILGRGSGCDIVIDDPGISRHHLGIDITPDGVIARDLGSTNGTYVEGHQVPAATLVDGNTITIGRTRILY 225
Cdd:cd22720   16 GSRFLLDQAITSAGRHPDSDIFLDDVTVSRRHAEFRLENNEFNVVDVGSLNGTYVNREPVDSAVLANGDEVQIGKFRLVF 95

Predicted component of the type VI protein secretion system, contains a FHA domain [Signal transduction mechanisms, Intracellular trafficking, secretion, and vesicular transport];

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502677987 138 NHPMLEING-NQYLLTKDRTILGRGSGCDIVIDDPG--ISRHHLGIDITPDGVIARDLgSTNGTYVEGHQVPA-----AT 209
Cdd:COG3456    9 NSPDLESGSaASATFGRGGGTIGRSADCDWVLPDPDrsVSRRHAEIRFRDGAFCLTDL-STNGTFLNGSDHPLgpgrpVR 87

                         90
                 ....*....|....*
gi 502677987 210 LVDGNTITIGRTRIL 224
Cdd:COG3456   88 LRDGDRLRIGDYEIR 102

forkhead associated (FHA) domain found in kanadaptin and similar proteins; Kanadaptin, also called human lung cancer oncogene 3 protein (HLC-3), kidney anion exchanger adapter protein, or solute carrier family 4 anion exchanger member 1 adapter protein (SLC4A1AP), is a nuclear protein widely expressed in mammalian tissues. It was originally isolated as a kidney Cl-/HCO3- anion exchanger 1 (kAE1)-binding protein. It is a highly mobile nucleocytoplasmic shuttling and multilocalizing protein. Its role in mammalian cells remains unclear. It contains an FHA domain, which is a small phosphopeptide recognition module.

                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 502677987 150 LLTKDRTILGRGSGCDIVIDDPGISRHHLGI------DITPDGVIARDLGSTNGTYVEGHQVPA 207
Cdd:cd22677   18 LNGKSFYVFGRLPGCDVVLEHPSISRYHAVLqyrgdaDDHDGGFYLYDLGSTHGTFLNKQRIPP 81

forkhead associated (FHA) domain found in forkhead-associated domain-containing protein 1 (FHAD1) and similar proteins; FHAD1, also called FHA domain-containing protein 1, is an uncharacterized FHA domain-containing protein. The FHA domain is a small phosphopeptide recognition module.

                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 502677987 149 YLLTKDRTILGRGsGCDIVIDDPGISRHHLGIDITP--DGVIARDLGSTNGTYVEGHQVPAAT 209
Cdd:cd22700   11 FQLDPKVTTIGRE-GCDLVLQSPGVEEQHAVIEYSEqeNCFVLQDLNTAQGTYVNDCRIQNAA 72

forkhead associated (FHA) domain found in angiogenic factor with G patch and FHA domains 1 (AGGF1) and similar proteins; AGGF1, also called angiogenic factor VG5Q, or G patch domain-containing protein 7 (GPATC7), or vasculogenesis gene on 5q protein, is an angiogenic factor involved in vascular development, angiogenesis, specification of hemangioblasts, and differentiation of veins. It promotes angiogenesis and the proliferation of endothelial cells. It inhibits inflammatory effect and preserve vascular integrity in non-nervous system diseases. Mutated AGGF1 causes susceptibility to Klippel-Trenaunay syndrome, a vascular disorder. Increased AGGF1 expression is associated with tumor angiogenesis. The FHA domain is a small phosphopeptide recognition module.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502677987 146 GNQYLLTKDRTILGRGSGC--DIVIDDPGISRHHLGIDITPD--GVIARDLGSTNGTYVEGHQVPAAT-------LVDGN 214
Cdd:cd22686   18 GSLFIVTATGATIGREKDHghTIRIPELGVSKFHAEIYYDDDeqSYTIVDLGSQNGTYLNGVRISQPKeksdpypLTHGD 97

                         90
                 ....*....|
gi 502677987 215 TITIGRTRIL 224
Cdd:cd22686   98 ELKIGETTLL 107

forkhead associated (FHA) domain found in nibrin and similar proteins; Nibrin (NBN), also called cell cycle regulatory protein p95, or Nijmegen breakage syndrome protein 1 (NBS1), is a novel DNA double-strand break repair protein that is mutated in Nijmegen breakage syndrome. It is a component of the MRE11-RAD50-NBN (MRN complex) which plays a critical role in the cellular response to DNA damage and the maintenance of chromosome integrity. Nibrin modulates the DNA damage signal sensing by recruiting PI3/PI4-kinase family members ATM, ATR, and probably DNA-dependent protein kinase catalytic subunit (DNA-PKcs) to the DNA damage sites and activating their functions. It can also recruit MRE11 and RAD50 to the proximity of DSBs by an interaction with the histone H2AX. Nibrin also functions in telomere length maintenance by generating the 3' overhang which serves as a primer for telomerase dependent telomere elongation. Nibrin is a major player in the control of intra-S-phase checkpoint. This subfamily also includes Schizosaccharomyces pombe DNA repair and telomere maintenance protein Nbs1 and Arabidopsis thaliana AtNbs1. SpNbs1 is an FHA domain-containing protein required for DNA damage repair and S-phase DNA damage checkpoint. It is involved in telomere length maintenance and maintenance of chromatin structure. AtNbs1 is a component of MRN complex. It also functions in the very early stages of meiosis. The FHA domain is a small phosphopeptide recognition module.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502677987 149 YLLTKDRTILGRGSGCDIVIDDPGISRHHLGIDITPDGVIARDLG----------STNGTYVEGHQVPA---ATLVDGNT 215
Cdd:cd22667   15 YLLPGGEYTVGRKDCDIIIVDDSSISRKHATLTVLHPEANLSDPDtrpeltlkdlSKYGTFVNGEKLKGgseVTLKDGDV 94

                 ....
gi 502677987 216 ITIG 219
Cdd:cd22667   95 ITFG 98

first forkhead associated (FHA) domain found in Saccharomyces cerevisiae Serine/threonine-protein kinase RAD53 and similar proteins; RAD53, also called CHEK2 homolog, or serine-protein kinase 1 (Spk1), is a nuclear protein kinase that phosphorylates proteins on serine, threonine, and tyrosine. It controls S-phase checkpoint as well as G1 and G2 DNA damage checkpoints and prevents entry into anaphase and mitotic exit after DNA damage via regulation of the Polo kinase CDC5. It may be involved in the phosphorylation of RPH1. RAD53 contains two FHA domains. This model corresponds to the first one. The FHA domain is a small phosphopeptide recognition module.

                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 502677987 159 GRGSGCDIVIDDPGISRHHLGI---DITPDG--VIARDLgSTNGTYVEGHQVPAAT---LVDGNTITIG 219
Cdd:cd22689   50 GRHPACDYHLGNSRLSNKHFQIllgESDPSDgnVLLNDI-SSNGTWLNGQRLEKNSnqlLSQGDEITIG 117

forkhead associated (FHA) domain found in Mycobacterium tuberculosis transcriptional regulatory protein EmbR and similar proteins; EmbR is a transcriptional regulator of the embCAB operon encoding cell wall arabinosyltransferases (EmbC, -A, and -B), and is phosphorylated by the cognate mycobacterial serine/threonine protein kinase PknH. It interacts with RNA polymerase and possesses a phosphorylation-dependent ATPase activity. EmbR contains a regulatory C-terminal forkhead-associated (FHA) domain, which mediates binding to a threonine-phosphorylated site in PknH. The FHA domain is a small phosphopeptide recognition module.

                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 502677987 145 NGNQYLLTKDRTILGRGSGCDIVIDDPGISRHHLGIDITPDGVIARDLGSTNGTYVEGHQV-PAATLVDGNTITIG 219
Cdd:cd22669    7 SGRGYPLQAAATRIGRLHDNDIVLDSANVSRHHAVIVDTGTNYVINDLRSSNGVHVQHERIrSAVTLNDGDHIRIC 82

forkhead associated (FHA) domain found in Saccharomyces cerevisiae pre-mRNA leakage protein 1 (PML1) and similar proteins; PML1 is an FHA domain-containing protein required for efficient splicing and pre-mRNA nuclear retention. It is a component of the pre-mRNA retention and splicing (RES) complex composed of at least BUD13, IST3, and PML1. It contains an FHA domain, which is a small phosphopeptide recognition module.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502677987 150 LLTKDRTILGRGSG-------CDIVIDDPGISRHHLGI------DITPDGVIarDLGSTNGTYVEGHQVPAA---TLVDG 213
Cdd:cd22681   36 LNSPSCYLIGREKGesteivvADIGIPEETCSKQHCVIqfrnvkGILKPYIM--DLDSSNGTCLNDNVIPSSryvELRSG 113

                 ....
gi 502677987 214 NTIT 217
Cdd:cd22681  114 DVIT 117

forkhead associated (FHA) domain found in aprataxin, bifunctional polynucleotide phosphatase/kinase (PNKP), aprataxin and PNK-like factor (APLF), and similar proteins; The family includes aprataxin, PNKP, and APLF. Aprataxin (EC 3.6.1.71/EC 3.6.1.72), also called forkhead-associated domain histidine triad-like protein (FHA-HIT), is a DNA-binding protein involved in single-strand DNA break repair, double-strand DNA break repair, and base excision repair. It catalyzes the release of adenylate groups covalently linked to 5'-phosphate termini, resulting in the production of 5'-phosphate termini that can be efficiently rejoined. It can also hydrolyze adenosine 5'-monophosphoramidate (AMP-NH(2)) and diadenosine tetraphosphate (AppppA), but with lower catalytic activity. Likewise, it catalyzes the release of 3'-linked guanosine (DNAppG) and inosine (DNAppI) from DNA but has higher specific activity with 5'-linked adenosine (AppDNA). PNKP (EC 3.1.3.32/EC 2.7.1.78), also called DNA 5'-kinase/3'-phosphatase, or polynucleotide kinase-3'-phosphatase, plays a key role in the repair of DNA damage, functioning as part of both the non-homologous end-joining (NHEJ) and base excision repair (BER) pathways. Through its two catalytic activities, PNKP ensures that DNA termini are compatible with extension and ligation by either removing 3'-phosphates from, or by phosphorylating 5'-hydroxyl groups on, the ribose sugar of the DNA backbone. APLF, also called apurinic-apyrimidinic endonuclease APLF, PNK and APTX-like FHA domain-containing protein, or XRCC1-interacting protein 1 (XIP1), is a novel apurinic-apyrimidinic (AP) endonuclease and 3'-5' exonuclease with conserved zinc-finger-like motifs involved in single-strand and double-strand DNA break repair. It is recruited to sites of DNA damage through interaction with poly(ADP-ribose), a polymeric post-translational modification synthesized transiently at sites of chromosomal damage to accelerate DNA strand break repair reactions. It can introduce nicks at hydroxyuracil and other types of pyrimidine base damage. Together with PARP3, APLF promotes the retention of the LIG4-XRCC4 complex on chromatin and accelerate DNA ligation during non-homologous end-joining (NHEJ). Members of this family contain an FHA domain at their N-terminus. The FHA domain is a small phosphopeptide recognition module.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502677987 156 TILGRGSGCDIviDDPGISRHHLGIDITPDG--VIARDLGSTNGTYVEGHQVP-------AATLVDGNTITIGRTRILYW 226
Cdd:cd22671   21 TVLGRGPLLGI--RDKRVSRKQAEITVDDDTgsVTVTQLGTNPSFVNRADGEGkvlkkgeSVELKDGDVISLLPGKYPFR 98

forkhead associated (FHA) domain found in Arabidopsis thaliana FHA domain-containing protein DDL and similar proteins; DDL, also called protein DAWDLE, is involved in microRNA (miRNA) and short interfering RNA (siRNA) biogenesis. It may facilitate DCL1 to access or recognize primary miRNAs. DDL binds RNA non-specifically. The FHA domain is a small phosphopeptide recognition module.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502677987 134 DQSQNHPMLEINGNQYLLTKDRTIlgrgsgCDIVIDDPGISRHHLGIDI------TPDGVIAR-------DLGSTNGTYV 200
Cdd:cd22719   24 GEPLNEPLHIHRQSCYLFGRERKV------ADIPTDHPSCSKQHAVIQYrltekeGGDGMMGKavrpyimDLGSTNGTFL 97

                 ....*
gi 502677987 201 EGHQV 205
Cdd:cd22719   98 NGERI 102

forkhead associated (FHA) domain found in transcription factor 19 (TCF-19) and similar proteins; TCF-19, also called transcription factor SC1, was identified as a putative trans-activating factor with expression beginning at the late G1-S boundary in dividing cells. It also functions as a novel islet factor necessary for proliferation and survival in the INS-1 beta cell line. It plays an important role in susceptibility to both Type 1 Diabetes Mellitus (T1DM) and Type 2 Diabetes Mellitus (T2DM); it has been suggested that it may positively impact beta cell mass under conditions of beta cell stress and increased insulin demand. TCF-19 contains an N-terminal fork head association domain (FHA), a proline rich region, and a C-terminal plant homeodomain (PHD) finger. The FHA domain may serve as a nuclear signaling domain or as a phosphoprotein binding domain. The proline rich region is a common characteristic of trans-activating factors. The PHD finger may allow TCF-19 to interact with chromatin via methylated histone H3.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502677987 149 YLLTKDRTI--LGRGSG-CDIVIDDP----GISRHHLGIDITPDG-----VIARDLgSTNGTYVEGHQVPAAT---LVDG 213
Cdd:cd22685   21 YTFRPDLCEyrIGRNPEvCDVFLCSSqhpnLISREHAEIHAERDGngnwkVLIEDR-STNGTYVNDVRLQDGQrreLSDG 99

                 ....*.
gi 502677987 214 NTITIG 219
Cdd:cd22685  100 DTITFG 105