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Conserved domains on  [gi|502716242|ref|WP_012951271|]
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ATP phosphoribosyltransferase regulatory subunit [Listeria monocytogenes]

Protein Classification

ATP phosphoribosyltransferase regulatory subunit( domain architecture ID 11485747)

ATP phosphoribosyltransferase regulatory subunit is required for the first step of histidine biosynthesis

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
hisZ PRK12292
ATP phosphoribosyltransferase regulatory subunit; Provisional
 3-390 7.30e-133

ATP phosphoribosyltransferase regulatory subunit; Provisional


:

Pssm-ID: 237043 [Multi-domain]  Cd Length: 391  Bit Score: 386.14  E-value: 7.30e-133
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502716242   3 LNKNLPTGTRDKLFREARAAYKIEQQVNHYFEKRGFKRIETPVIEFEDVFSSE--HQADAKLYRFFDE-KGRLTVLRPDM 79
Cdd:PRK12292   1 MMWQLPEGIRDLLPEEARKIEEIRRRLLDLFRRWGYEEVITPTLEYLDTLLAGggAILDLRTFKLVDQlSGRTLGLRPDM 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502716242  80 TLPIGRVVSTT--GVMLPLKLSYSGKIFRANEDFGGEQNEQTQAGIEIIGYPSIKAEIECILIGIGVLNALEIPNFQIEL 157
Cdd:PRK12292  81 TAQIARIAATRlaNRPGPLRLCYAGNVFRAQERGLGRSREFLQSGVELIGDAGLEADAEVILLLLEALKALGLPNFTLDL 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502716242 158 GHAAIYRRVTNLLNLSETAEIDFRLLIQNKSLTGIKRFVADNPSTLDDFILVLPRLFGPAtAILKQAKNLTTDKGILTAL 237
Cdd:PRK12292 161 GHVGLFRALLEAAGLSEELEEVLRRALANKDYVALEELVLDLSEELRDALLALPRLRGGR-EVLEEARKLLPSLPIKRAL 239

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502716242 238 REMETIVEAVS---YTADISVDLGLVQDFHYYTGIIFRGYADLAADNFLSGGRYDHLLEQFTSAsSPAVGLALNLDSLTT 314
Cdd:PRK12292 240 DELEALAEALEkygYGIPLSLDLGLLRHLDYYTGIVFEGYVDGVGNPIASGGRYDDLLGRFGRA-RPATGFSLDLDRLLE 318

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502716242 315 LQnraGVIKKQVSTSLLIHYDLDAIQQAEKLMQETPNS----ELSFF-ETPTNAISFAKKWHIpavihVSRQGIQTIFQR 389
Cdd:PRK12292 319 LQ---LELPVEARKDLVIAPDSEALAAALAAAQELRKKgeivVLALPgRNFEDAREYARDRQI-----VEADGEWQVEPL 390


                 .
gi 502716242 390 E 390
Cdd:PRK12292 391 A 391
 
Name Accession Description Interval E-value
hisZ PRK12292
ATP phosphoribosyltransferase regulatory subunit; Provisional
 3-390 7.30e-133

ATP phosphoribosyltransferase regulatory subunit; Provisional


Pssm-ID: 237043 [Multi-domain]  Cd Length: 391  Bit Score: 386.14  E-value: 7.30e-133
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502716242   3 LNKNLPTGTRDKLFREARAAYKIEQQVNHYFEKRGFKRIETPVIEFEDVFSSE--HQADAKLYRFFDE-KGRLTVLRPDM 79
Cdd:PRK12292   1 MMWQLPEGIRDLLPEEARKIEEIRRRLLDLFRRWGYEEVITPTLEYLDTLLAGggAILDLRTFKLVDQlSGRTLGLRPDM 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502716242  80 TLPIGRVVSTT--GVMLPLKLSYSGKIFRANEDFGGEQNEQTQAGIEIIGYPSIKAEIECILIGIGVLNALEIPNFQIEL 157
Cdd:PRK12292  81 TAQIARIAATRlaNRPGPLRLCYAGNVFRAQERGLGRSREFLQSGVELIGDAGLEADAEVILLLLEALKALGLPNFTLDL 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502716242 158 GHAAIYRRVTNLLNLSETAEIDFRLLIQNKSLTGIKRFVADNPSTLDDFILVLPRLFGPAtAILKQAKNLTTDKGILTAL 237
Cdd:PRK12292 161 GHVGLFRALLEAAGLSEELEEVLRRALANKDYVALEELVLDLSEELRDALLALPRLRGGR-EVLEEARKLLPSLPIKRAL 239

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502716242 238 REMETIVEAVS---YTADISVDLGLVQDFHYYTGIIFRGYADLAADNFLSGGRYDHLLEQFTSAsSPAVGLALNLDSLTT 314
Cdd:PRK12292 240 DELEALAEALEkygYGIPLSLDLGLLRHLDYYTGIVFEGYVDGVGNPIASGGRYDDLLGRFGRA-RPATGFSLDLDRLLE 318

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502716242 315 LQnraGVIKKQVSTSLLIHYDLDAIQQAEKLMQETPNS----ELSFF-ETPTNAISFAKKWHIpavihVSRQGIQTIFQR 389
Cdd:PRK12292 319 LQ---LELPVEARKDLVIAPDSEALAAALAAAQELRKKgeivVLALPgRNFEDAREYARDRQI-----VEADGEWQVEPL 390


                 .
gi 502716242 390 E 390
Cdd:PRK12292 391 A 391
hisZ_biosyn_reg TIGR00443
ATP phosphoribosyltransferase, regulatory subunit; Apparant second copies of histidyl-tRNA ...
 12-317 1.74e-127

ATP phosphoribosyltransferase, regulatory subunit; Apparant second copies of histidyl-tRNA synthetase, found in Bacillus subtilis, Synechocystis sp., Aquifex aeolicus, and others, are in fact a regulatory subunit of ATP phosphoribosyltransferase, and usually encoded by a gene adjacent to that encoding the catalytic subunit. [Amino acid biosynthesis, Histidine family]


Pssm-ID: 273081 [Multi-domain]  Cd Length: 313  Bit Score: 369.25  E-value: 1.74e-127
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502716242   12 RDKLFREARAAYKIEQQVNHYFEKRGFKRIETPVIEFEDVFSSEHQ-ADAKLYRFFDEKGRLTVLRPDMTLPIGRVVSTT 90
Cdd:TIGR00443   1 RDLLPEEAARKEEIERQLQDVFRSWGYQEIITPTLEYLDTLSAGSGiLNEDLFKLFDQLGRVLGLRPDMTAPIARLVSTR 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502716242   91 --GVMLPLKLSYSGKIFRANEDFGGEQNEQTQAGIEIIGYPSIKAEIECILIGIGVLNALEIPNFQIELGHAAIYRRVTN 168
Cdd:TIGR00443  81 lrDRPLPLRLCYAGNVFRTNESGGGRSREFTQAGVELIGAGGPAADAEVIALLIEALKALGLKDFKIELGHVGLVRALLE 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502716242  169 LLNLSETAEIDFRLLIQNKSLTGIKRFVADNPST--LDDFILVLPRLFGPATAILKQAKNLTTDKGILTALREMET---I 243
Cdd:TIGR00443 161 EAGLPEEAREALREALARKDLVALEELVAELGLSpeVRERLLALPRLRGDGEEVLEEARALAGSETAEAALDELEAvleL 240

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 502716242  244 VEAVSYTADISVDLGLVQDFHYYTGIIFRGYADLAADNFLSGGRYDHLLEQFtSASSPAVGLALNLDSLTTLQN 317
Cdd:TIGR00443 241 LEARGVEEYISLDLGLVRGYHYYTGLIFEGYAPGLGAPLAGGGRYDELLGRF-GRPLPATGFALNLERLLEALT 313
HisZ COG3705
ATP phosphoribosyltransferase regulatory subunit HisZ [Amino acid transport and metabolism];
15-319 3.57e-102

ATP phosphoribosyltransferase regulatory subunit HisZ [Amino acid transport and metabolism];


Pssm-ID: 442919 [Multi-domain]  Cd Length: 312  Bit Score: 304.79  E-value: 3.57e-102
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502716242  15 LFREARAAYKIEQQVNHYFEKRGFKRIETPVIEFEDVFSSEHQAD--AKLYRFFDEKGRLTVLRPDMTLPIGRVVST--T 90
Cdd:COG3705    1 LPEEAARKEELRRRLLDVFRSWGYELVEPPLLEYLDSLLTGSGADldLQTFKLVDQLGRTLGLRPDMTPQVARIAATrlA 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502716242  91 GVMLPLKLSYSGKIFRANEDFGGEQNEQTQAGIEIIGYPSIKAEIECILIGIGVLNALEIPNFQIELGHAAIYRRVTNLL 170
Cdd:COG3705   81 NRPGPLRLCYAGNVFRTRPSGLGRSREFLQAGAELIGHAGLEADAEVIALALEALKAAGLEDFTLDLGHVGLFRALLEAL 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502716242 171 NLSETAEIDFRLLIQNKSLTGIKRFVADN--PSTLDDFILVLPRLFGPATAiLKQAKNLTTDKGILTALREMETIVEAVS 248
Cdd:COG3705  161 GLSEEQREELRRALARKDAVELEELLAELglSEELAEALLALPELYGGEEV-LARARALLLDAAIRAALDELEALAEALA 239

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 502716242 249 ---YTADISVDLGLVQDFHYYTGIIFRGYADLAADNFLSGGRYDHLLEQFtSASSPAVGLALNLDSLTTLQNRA 319
Cdd:COG3705  240 argPDVRLTFDLSELRGYDYYTGIVFEAYAPGVGDPLARGGRYDGLLAAF-GRARPATGFSLDLDRLLRALPAA 312
HisRS-like_core cd00773
Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. ...
 18-312 2.74e-79

Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent formation of the enzyme bound aminoacyl-adenylate. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. This domain is also found at the C-terminus of eukaryotic GCN2 protein kinase and at the N-terminus of the ATP phosphoribosyltransferase accessory subunit, HisZ. HisZ along with HisG catalyze the first reaction in histidine biosynthesis. HisZ is found only in a subset of bacteria and differs from HisRS in lacking a C-terminal anti-codon binding domain.


Pssm-ID: 238396 [Multi-domain]  Cd Length: 261  Bit Score: 244.82  E-value: 2.74e-79
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502716242  18 EARAAYKIEQQVNHYFEKRGFKRIETPVIEFEDVF--SSEHQADAKLYRFFDEKGRLTVLRPDMTLPIGRVVSTTGVML- 94
Cdd:cd00773    1 EAALRRYIEDTLREVFERYGYEEIDTPVFEYTELFlrKSGDEVSKEMYRFKDKGGRDLALRPDLTAPVARAVAENLLSLp 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502716242  95 -PLKLSYSGKIFRANEDFGGEQNEQTQAGIEIIGYPSIKAEIECILIGIGVLNALEIPNFQIELGHAAIYRRVTNLLNLS 173
Cdd:cd00773   81 lPLKLYYIGPVFRYERPQKGRYREFYQVGVEIIGSDSPLADAEVIALAVEILEALGLKDFQIKINHRGILDGIAGLLEDR 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502716242 174 ETAEIDFRLLIQNKSLTgikrfvadnpstlddfilvlprlfgpatailkqaknlttdkgiltALREMETIVEAVSYTADI 253
Cdd:cd00773  161 EEYIERLIDKLDKEALA---------------------------------------------HLEKLLDYLEALGVDIKY 195

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 502716242 254 SVDLGLVQDFHYYTGIIFRGYAD--LAADNFLSGGRYDHLLEQFTSASSPAVGLALNLDSL 312
Cdd:cd00773  196 SIDLSLVRGLDYYTGIVFEAVADglGAQGSIAGGGRYDGLLEEFGGEDVPAVGFAIGLERL 256
tRNA-synt_His pfam13393
Histidyl-tRNA synthetase; This is a family of class II aminoacyl-tRNA synthetase-like and ATP ...
 10-312 3.65e-72

Histidyl-tRNA synthetase; This is a family of class II aminoacyl-tRNA synthetase-like and ATP phosphoribosyltransferase regulatory subunits.


Pssm-ID: 433170 [Multi-domain]  Cd Length: 309  Bit Score: 227.85  E-value: 3.65e-72
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502716242   10 GTRDKLFREARAAYKIEQQVNHYFEKRGFKRIETPVIEFEDVFSSEHQADAK-LYRFFDEKGRLTVLRPDMTLPIGRVVS 88
Cdd:pfam13393   1 GIRDLLPPEARRIEELRRRLLDLFRSWGYELVMPPLLEYLDSLLTGTGADLDqTFKLVDQSGRLLGLRADITPQVARIDA 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502716242   89 TtgvML----PLKLSYSGKIFRANEDFGGEQNEQTQAGIEIIGYPSIKAEIECILIGIGVLNALEIPNFQIELGHAAIYR 164
Cdd:pfam13393  81 H---RLnrpgPLRLCYAGSVLRTRPKGLGRSREPLQVGAELIGHAGIEADAEIISLLLEALAAAGVPGVTLDLGHVGLVR 157

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502716242  165 RVTNLLNLSETAEIDFRLLIQNKSLTGIKRFVADN--PSTLDDFILVLPRLFGPATAILKQAKNLTTDKGI---LTALRE 239
Cdd:pfam13393 158 ALLEAAGLSEALEEALRAALQRKDAAELAELAAEAglPPALRRALLALPDLYGGPEVLDEARAALPGLPALqeaLDELEA 237

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 502716242  240 METIVEAVSYTADISVDLGLVQDFHYYTGIIFRGYADLAADNFLSGGRYDHLLEQFTSAsSPAVGLALNLDSL 312
Cdd:pfam13393 238 LAALLEALGDGVRLTFDLAELRGYEYYTGIVFAAYAPGVGEPLARGGRYDDLGAAFGRA-RPATGFSLDLEAL 309
 
Name Accession Description Interval E-value
hisZ PRK12292
ATP phosphoribosyltransferase regulatory subunit; Provisional
 3-390 7.30e-133

ATP phosphoribosyltransferase regulatory subunit; Provisional


Pssm-ID: 237043 [Multi-domain]  Cd Length: 391  Bit Score: 386.14  E-value: 7.30e-133
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502716242   3 LNKNLPTGTRDKLFREARAAYKIEQQVNHYFEKRGFKRIETPVIEFEDVFSSE--HQADAKLYRFFDE-KGRLTVLRPDM 79
Cdd:PRK12292   1 MMWQLPEGIRDLLPEEARKIEEIRRRLLDLFRRWGYEEVITPTLEYLDTLLAGggAILDLRTFKLVDQlSGRTLGLRPDM 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502716242  80 TLPIGRVVSTT--GVMLPLKLSYSGKIFRANEDFGGEQNEQTQAGIEIIGYPSIKAEIECILIGIGVLNALEIPNFQIEL 157
Cdd:PRK12292  81 TAQIARIAATRlaNRPGPLRLCYAGNVFRAQERGLGRSREFLQSGVELIGDAGLEADAEVILLLLEALKALGLPNFTLDL 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502716242 158 GHAAIYRRVTNLLNLSETAEIDFRLLIQNKSLTGIKRFVADNPSTLDDFILVLPRLFGPAtAILKQAKNLTTDKGILTAL 237
Cdd:PRK12292 161 GHVGLFRALLEAAGLSEELEEVLRRALANKDYVALEELVLDLSEELRDALLALPRLRGGR-EVLEEARKLLPSLPIKRAL 239

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502716242 238 REMETIVEAVS---YTADISVDLGLVQDFHYYTGIIFRGYADLAADNFLSGGRYDHLLEQFTSAsSPAVGLALNLDSLTT 314
Cdd:PRK12292 240 DELEALAEALEkygYGIPLSLDLGLLRHLDYYTGIVFEGYVDGVGNPIASGGRYDDLLGRFGRA-RPATGFSLDLDRLLE 318

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502716242 315 LQnraGVIKKQVSTSLLIHYDLDAIQQAEKLMQETPNS----ELSFF-ETPTNAISFAKKWHIpavihVSRQGIQTIFQR 389
Cdd:PRK12292 319 LQ---LELPVEARKDLVIAPDSEALAAALAAAQELRKKgeivVLALPgRNFEDAREYARDRQI-----VEADGEWQVEPL 390


                 .
gi 502716242 390 E 390
Cdd:PRK12292 391 A 391
hisZ_biosyn_reg TIGR00443
ATP phosphoribosyltransferase, regulatory subunit; Apparant second copies of histidyl-tRNA ...
 12-317 1.74e-127

ATP phosphoribosyltransferase, regulatory subunit; Apparant second copies of histidyl-tRNA synthetase, found in Bacillus subtilis, Synechocystis sp., Aquifex aeolicus, and others, are in fact a regulatory subunit of ATP phosphoribosyltransferase, and usually encoded by a gene adjacent to that encoding the catalytic subunit. [Amino acid biosynthesis, Histidine family]


Pssm-ID: 273081 [Multi-domain]  Cd Length: 313  Bit Score: 369.25  E-value: 1.74e-127
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502716242   12 RDKLFREARAAYKIEQQVNHYFEKRGFKRIETPVIEFEDVFSSEHQ-ADAKLYRFFDEKGRLTVLRPDMTLPIGRVVSTT 90
Cdd:TIGR00443   1 RDLLPEEAARKEEIERQLQDVFRSWGYQEIITPTLEYLDTLSAGSGiLNEDLFKLFDQLGRVLGLRPDMTAPIARLVSTR 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502716242   91 --GVMLPLKLSYSGKIFRANEDFGGEQNEQTQAGIEIIGYPSIKAEIECILIGIGVLNALEIPNFQIELGHAAIYRRVTN 168
Cdd:TIGR00443  81 lrDRPLPLRLCYAGNVFRTNESGGGRSREFTQAGVELIGAGGPAADAEVIALLIEALKALGLKDFKIELGHVGLVRALLE 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502716242  169 LLNLSETAEIDFRLLIQNKSLTGIKRFVADNPST--LDDFILVLPRLFGPATAILKQAKNLTTDKGILTALREMET---I 243
Cdd:TIGR00443 161 EAGLPEEAREALREALARKDLVALEELVAELGLSpeVRERLLALPRLRGDGEEVLEEARALAGSETAEAALDELEAvleL 240

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 502716242  244 VEAVSYTADISVDLGLVQDFHYYTGIIFRGYADLAADNFLSGGRYDHLLEQFtSASSPAVGLALNLDSLTTLQN 317
Cdd:TIGR00443 241 LEARGVEEYISLDLGLVRGYHYYTGLIFEGYAPGLGAPLAGGGRYDELLGRF-GRPLPATGFALNLERLLEALT 313
HisZ COG3705
ATP phosphoribosyltransferase regulatory subunit HisZ [Amino acid transport and metabolism];
15-319 3.57e-102

ATP phosphoribosyltransferase regulatory subunit HisZ [Amino acid transport and metabolism];


Pssm-ID: 442919 [Multi-domain]  Cd Length: 312  Bit Score: 304.79  E-value: 3.57e-102
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502716242  15 LFREARAAYKIEQQVNHYFEKRGFKRIETPVIEFEDVFSSEHQAD--AKLYRFFDEKGRLTVLRPDMTLPIGRVVST--T 90
Cdd:COG3705    1 LPEEAARKEELRRRLLDVFRSWGYELVEPPLLEYLDSLLTGSGADldLQTFKLVDQLGRTLGLRPDMTPQVARIAATrlA 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502716242  91 GVMLPLKLSYSGKIFRANEDFGGEQNEQTQAGIEIIGYPSIKAEIECILIGIGVLNALEIPNFQIELGHAAIYRRVTNLL 170
Cdd:COG3705   81 NRPGPLRLCYAGNVFRTRPSGLGRSREFLQAGAELIGHAGLEADAEVIALALEALKAAGLEDFTLDLGHVGLFRALLEAL 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502716242 171 NLSETAEIDFRLLIQNKSLTGIKRFVADN--PSTLDDFILVLPRLFGPATAiLKQAKNLTTDKGILTALREMETIVEAVS 248
Cdd:COG3705  161 GLSEEQREELRRALARKDAVELEELLAELglSEELAEALLALPELYGGEEV-LARARALLLDAAIRAALDELEALAEALA 239

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 502716242 249 ---YTADISVDLGLVQDFHYYTGIIFRGYADLAADNFLSGGRYDHLLEQFtSASSPAVGLALNLDSLTTLQNRA 319
Cdd:COG3705  240 argPDVRLTFDLSELRGYDYYTGIVFEAYAPGVGDPLARGGRYDGLLAAF-GRARPATGFSLDLDRLLRALPAA 312
HisRS-like_core cd00773
Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. ...
 18-312 2.74e-79

Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent formation of the enzyme bound aminoacyl-adenylate. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. This domain is also found at the C-terminus of eukaryotic GCN2 protein kinase and at the N-terminus of the ATP phosphoribosyltransferase accessory subunit, HisZ. HisZ along with HisG catalyze the first reaction in histidine biosynthesis. HisZ is found only in a subset of bacteria and differs from HisRS in lacking a C-terminal anti-codon binding domain.


Pssm-ID: 238396 [Multi-domain]  Cd Length: 261  Bit Score: 244.82  E-value: 2.74e-79
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502716242  18 EARAAYKIEQQVNHYFEKRGFKRIETPVIEFEDVF--SSEHQADAKLYRFFDEKGRLTVLRPDMTLPIGRVVSTTGVML- 94
Cdd:cd00773    1 EAALRRYIEDTLREVFERYGYEEIDTPVFEYTELFlrKSGDEVSKEMYRFKDKGGRDLALRPDLTAPVARAVAENLLSLp 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502716242  95 -PLKLSYSGKIFRANEDFGGEQNEQTQAGIEIIGYPSIKAEIECILIGIGVLNALEIPNFQIELGHAAIYRRVTNLLNLS 173
Cdd:cd00773   81 lPLKLYYIGPVFRYERPQKGRYREFYQVGVEIIGSDSPLADAEVIALAVEILEALGLKDFQIKINHRGILDGIAGLLEDR 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502716242 174 ETAEIDFRLLIQNKSLTgikrfvadnpstlddfilvlprlfgpatailkqaknlttdkgiltALREMETIVEAVSYTADI 253
Cdd:cd00773  161 EEYIERLIDKLDKEALA---------------------------------------------HLEKLLDYLEALGVDIKY 195

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 502716242 254 SVDLGLVQDFHYYTGIIFRGYAD--LAADNFLSGGRYDHLLEQFTSASSPAVGLALNLDSL 312
Cdd:cd00773  196 SIDLSLVRGLDYYTGIVFEAVADglGAQGSIAGGGRYDGLLEEFGGEDVPAVGFAIGLERL 256
tRNA-synt_His pfam13393
Histidyl-tRNA synthetase; This is a family of class II aminoacyl-tRNA synthetase-like and ATP ...
 10-312 3.65e-72

Histidyl-tRNA synthetase; This is a family of class II aminoacyl-tRNA synthetase-like and ATP phosphoribosyltransferase regulatory subunits.


Pssm-ID: 433170 [Multi-domain]  Cd Length: 309  Bit Score: 227.85  E-value: 3.65e-72
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502716242   10 GTRDKLFREARAAYKIEQQVNHYFEKRGFKRIETPVIEFEDVFSSEHQADAK-LYRFFDEKGRLTVLRPDMTLPIGRVVS 88
Cdd:pfam13393   1 GIRDLLPPEARRIEELRRRLLDLFRSWGYELVMPPLLEYLDSLLTGTGADLDqTFKLVDQSGRLLGLRADITPQVARIDA 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502716242   89 TtgvML----PLKLSYSGKIFRANEDFGGEQNEQTQAGIEIIGYPSIKAEIECILIGIGVLNALEIPNFQIELGHAAIYR 164
Cdd:pfam13393  81 H---RLnrpgPLRLCYAGSVLRTRPKGLGRSREPLQVGAELIGHAGIEADAEIISLLLEALAAAGVPGVTLDLGHVGLVR 157

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502716242  165 RVTNLLNLSETAEIDFRLLIQNKSLTGIKRFVADN--PSTLDDFILVLPRLFGPATAILKQAKNLTTDKGI---LTALRE 239
Cdd:pfam13393 158 ALLEAAGLSEALEEALRAALQRKDAAELAELAAEAglPPALRRALLALPDLYGGPEVLDEARAALPGLPALqeaLDELEA 237

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 502716242  240 METIVEAVSYTADISVDLGLVQDFHYYTGIIFRGYADLAADNFLSGGRYDHLLEQFTSAsSPAVGLALNLDSL 312
Cdd:pfam13393 238 LAALLEALGDGVRLTFDLAELRGYEYYTGIVFAAYAPGVGEPLARGGRYDDLGAAFGRA-RPATGFSLDLEAL 309
HisS COG0124
Histidyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Histidyl-tRNA ...
 6-348 1.53e-45

Histidyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Histidyl-tRNA synthetase is part of the Pathway/BioSystem: Aminoacyl-tRNA synthetases


Pssm-ID: 439894 [Multi-domain]  Cd Length: 422  Bit Score: 161.83  E-value: 1.53e-45
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502716242   6 NLPTGTRDKLFREARAAYKIEQQVNHYFEKRGFKRIETPVIEFEDVF---SSEHQADAKLYRFFDEKGRLTVLRPDMTLP 82
Cdd:COG0124    5 QAPRGTRDILPEESAKWQYVEDTIREVFERYGFQEIRTPIFEYTELFarkIGEDIVEKEMYTFEDRGGRSLTLRPEGTAP 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502716242  83 IGRVVSTTGVML--PLKLSYSGKIFRAnedfggeqnEQ---------TQAGIEIIGYPSIKAEIECILIGIGVLNALEIP 151
Cdd:COG0124   85 VARAVAEHGNELpfPFKLYYIGPVFRY---------ERpqkgryrqfHQFGVEVIGSDSPLADAEVIALAADLLKALGLK 155

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502716242 152 NFQIELGHaaiyrrvtnlLNLSETAEIDFRLLIQNKSLTGIKRFVAD--------NPstlddfILVLPRLFGPAT-AILK 222
Cdd:COG0124  156 DFTLEINS----------RGLPEERAEALLRYLDKLDKIGHEDVLDEdsqrrletNP------LRAILDSKGPDCqEVLA 219

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502716242 223 QAKNLtTDKGILTALREMETIVEAV-SYTADISVDLGLVQDFHYYTGIIFRGYAD-LAADN-FLSGGRYDHLLEQFTSAS 299
Cdd:COG0124  220 DAPKL-LDYLGEEGLAHFEEVLELLdALGIPYVIDPRLVRGLDYYTGTVFEIVTDgLGAQGsVCGGGRYDGLVEQLGGPP 298

                        330       340       350       360       370
                 ....*....|....*....|....*....|....*....|....*....|.
gi 502716242 300 SPAVGLALNLDSLTTLQNRAGVIKKQVSTS--LLIHYDLDAIQQAEKLMQE 348
Cdd:COG0124  299 TPAVGFAIGLERLLLLLEELGLLPAAEPPPdvYVVPLGEEARAEALKLAQE 349
PRK12421 PRK12421
ATP phosphoribosyltransferase regulatory subunit; Provisional
 7-316 5.89e-37

ATP phosphoribosyltransferase regulatory subunit; Provisional


Pssm-ID: 237098  Cd Length: 392  Bit Score: 138.18  E-value: 5.89e-37
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502716242   7 LPTGTRDKLFREARAAYKIEQQVNHYFEKRGFKRIETPVIEFEDVFSSEHQADAKL--YRFFDE-KGRLTVLRPDMTLPI 83
Cdd:PRK12421   9 LPDGVADVLPEEAQKIERLRRRLLDLFASRGYQLVMPPLIEYLESLLTGAGQDLKLqtFKLIDQlSGRLMGVRADITPQV 88

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502716242  84 GRVVS-TTGVMLPLKLSYSGKIFRANED-FGGEQNEqTQAGIEIIGYPSIKAEIECILIGIGVLNALEIPNFQIELGHAA 161
Cdd:PRK12421  89 ARIDAhLLNREGVARLCYAGSVLHTLPQgLFGSRTP-LQLGAELYGHAGIEADLEIIRLMLGLLRNAGVPALHLDLGHVG 167

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502716242 162 IYRRVTNLLNLSETAEIDFRLLIQNKSLTGIKRFVADNP--STLDDFILVLPRLFGPATAIL-KQAKNLTTDKGILTALR 238
Cdd:PRK12421 168 IFRRLAELAGLSPEEEEELFDLLQRKALPELAEVCQNLGvgSDLRRMFYALARLNGGLEALDrALSVLALQDAAIRQALD 247

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502716242 239 EMETIVEAVSYTAD---ISVDLGLVQDFHYYTGIIFRGYADLAADNFLSGGRYDHLLEQFTSAsSPAVGLALNLDSLTTL 315
Cdd:PRK12421 248 ELKTLAAHLKNRWPelpVSIDLAELRGYHYHTGLVFAAYIPGRGQALARGGRYDGIGEAFGRA-RPATGFSMDLKELLAL 326


                 .
gi 502716242 316 Q 316
Cdd:PRK12421 327 Q 327
PLN02972 PLN02972
Histidyl-tRNA synthetase
 7-384 7.15e-23

Histidyl-tRNA synthetase


Pssm-ID: 215525 [Multi-domain]  Cd Length: 763  Bit Score: 100.73  E-value: 7.15e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502716242   7 LPTGTRDkLFREARA----AYKIEQQVnhyFEKRGFKRIETPVIEFEDVFSSEHQADAKL-YRFFDEKGRLTVLRPDMTL 81
Cdd:PLN02972 329 IPKGTRD-FAKEQMAirekAFSIITSV---FKRHGATALDTPVFELRETLMGKYGEDSKLiYDLADQGGELCSLRYDLTV 404

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502716242  82 PIGRVVSTTGVMlPLKLSYSGKIFRANEDFGGEQNEQTQAGIEIIG-YPSIKAEIECILIGIGVLNALEIPNFQIELGHA 160
Cdd:PLN02972 405 PFARYVAMNGIT-SFKRYQIAKVYRRDNPSKGRYREFYQCDFDIAGvYEPMGPDFEIIKVLTELLDELDIGTYEVKLNHR 483

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502716242 161 AIyrrVTNLLNLSETAEIDFRLL------IQNKSLTGIKRFVADN---PSTLDDFILVLPRLFGPATAILKQAKN----L 227
Cdd:PLN02972 484 KL---LDGMLEICGVPPEKFRTIcssidkLDKQSFEQVKKEMVEEkglSNETADKIGNFVKERGPPLELLSKLRQegseF 560

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502716242 228 TTDKGILTALREMETIVEAVSYTA---DISVDLGLVQDFHYYTGIIFRGYADLA-ADNFLSGGRYDHLLEQFTSASSPAV 303
Cdd:PLN02972 561 LGNASSRAALDELEIMFKALEKSKaigKIVFDLSLARGLDYYTGVIYEAVFKGAqVGSIAAGGRYDNLVGMFSGKQVPAV 640

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502716242 304 GLALNLDSLTT----LQNRAGVIKKQVSTSLLIHYDLDAIQ-QAEKLMQETPNSELSFFETPT----NAISFAKKWHIPA 374
Cdd:PLN02972 641 GVSLGIERVFAimeqQEEEKSQVIRPTETEVLVSIIGDDKLaLAAELVSELWNAGIKAEYKVStrkaKHLKRAKESGIPW 720

                        410
                 ....*....|
gi 502716242 375 VIHVSRQGIQ 384
Cdd:PLN02972 721 MVLVGEKELS 730
hisZ PRK12295
ATP phosphoribosyltransferase regulatory subunit; Provisional
 33-315 6.27e-18

ATP phosphoribosyltransferase regulatory subunit; Provisional


Pssm-ID: 183413 [Multi-domain]  Cd Length: 373  Bit Score: 84.21  E-value: 6.27e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502716242  33 FEKRGFKRIETPVIEFEDVF---SSEhqaD--AKLYRFFDEKGRLTVLRPDMTLPIGRVVSTTGVMLPLKLSYSGKIFRA 107
Cdd:PRK12295  18 FEAAGAVRVDPPILQPAEPFldlSGE---DirRRIFVTSDENGEELCLRPDFTIPVCRRHIATAGGEPARYAYLGEVFRQ 94

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502716242 108 NedfGGEQNEQTQAGIEIIGYPSI-KAEIECILIGIGVLNALEIPNFQIELGHAAIYRRVTNLLNLSE------------ 174
Cdd:PRK12295  95 R---RDRASEFLQAGIESFGRADPaAADAEVLALALEALAALGPGDLEVRLGDVGLFAALVDALGLPPgwkrrllrhfgr 171

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502716242 175 -------------------------------------------------------TAEIDFRLLIQnKSLTGIKRFVADN 199
Cdd:PRK12295 172 prsldallarlagprvdpldehagvlaaladeaaaralvedlmsiagispvggrsPAEIARRLLEK-AALAAAARLPAEA 250

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502716242 200 PSTLDDFIlvlpRLFGPATAILKQAKNLTTDKG--ILTALREMETIVEAVsytADISVDLGLV-------QDFHYYTGII 270
Cdd:PRK12295 251 LAVLERFL----AISGPPDAALAALRALAADAGldLDAALDRFEARLAAL---AARGIDLERLrfsasfgRPLDYYTGFV 323

                        330       340       350       360
                 ....*....|....*....|....*....|....*....|....*..
gi 502716242 271 FRGY-ADLAADNFLSGGRYDHLLEQFTSASS-PAVGLALNLDSLTTL 315
Cdd:PRK12295 324 FEIRaAGNGDPPLAGGGRYDGLLTRLGAGEPiPAVGFSIWLDRLAAL 370
PRK12420 PRK12420
histidyl-tRNA synthetase; Provisional
 10-318 1.42e-16

histidyl-tRNA synthetase; Provisional


Pssm-ID: 237097 [Multi-domain]  Cd Length: 423  Bit Score: 80.93  E-value: 1.42e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502716242  10 GTRDKLFREARAAYKIEQQVNHYFEKRGFKRIETPVIEFEDVFSSEHQADA----KLYRFFDEKGRLTVLRPDMTLPIGR 85
Cdd:PRK12420   9 GTKDYLPEEQVLRNKIKRALEDVFERYGCKPLETPTLNMYELMSSKYGGGDeilkEIYTLTDQGKRDLALRYDLTIPFAK 88

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502716242  86 VVSTT-GVMLPLKLSYSGKIFRANEDFGGEQNEQTQAGIEIIGYPSIKAEIECILIGIGVLNALEIPnfqielghaaIYR 164
Cdd:PRK12420  89 VVAMNpNIRLPFKRYEIGKVFRDGPIKQGRFREFIQCDVDIVGVESVMAEAELMSMAFELFRRLNLE----------VTI 158

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502716242 165 RVTNLLNLSETAEI---------DFRLL---IQNKSLTGIKRFVAD---NPSTLDDFI-LVLPRLFGPATAILKQAKNLT 228
Cdd:PRK12420 159 QYNNRKLLNGILQAigipteltsDVILSldkIEKIGIDGVRKDLLErgiSEEMADTICnTVLSCLQLSIADFKEAFNNPL 238

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502716242 229 TDKGIlTALREMETIVEAVSYTADISVDLGLVQDFHYYTGIIFRGY-ADLA-ADNFLSGGRYDHLLEQFTSASS--PAVG 304
Cdd:PRK12420 239 VAEGV-NELQQLQQYLIALGINENCIFNPFLARGLTMYTGTVYEIFlKDGSiTSSIGSGGRYDNIIGAFRGDDMnyPTVG 317

                        330
                 ....*....|....*
gi 502716242 305 LALNLDSLTT-LQNR 318
Cdd:PRK12420 318 ISFGLDVIYTaLSQK 332
syh CHL00201
histidine-tRNA synthetase; Provisional
 10-312 8.80e-16

histidine-tRNA synthetase; Provisional


Pssm-ID: 164576 [Multi-domain]  Cd Length: 430  Bit Score: 78.40  E-value: 8.80e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502716242  10 GTRDKLFREARAAYKIEQQVNHYFEKRGFKRIETPVIEFEDVFSSEHQADA-----KLYRFFDEKGRLTVLRPDMTLPIG 84
Cdd:CHL00201   9 GTKDILPDEINYWQFIHDKALTLLSLANYSEIRTPIFENSSLYDRGIGETTdivnkEMYRFTDRSNRDITLRPEGTAGIV 88

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502716242  85 RVVSTTGVMLP---LKLSYSGKIFRANEDFGGEQNEQTQAGIEIIGYPSIKAEIECILIGIGVLNALEIPNFQIELGH-A 160
Cdd:CHL00201  89 RAFIENKMDYHsnlQRLWYSGPMFRYERPQSGRQRQFHQLGIEFIGSIDARADTEVIHLAMQIFNELQVKNLILDINSiG 168

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502716242 161 AIYRRVTNLLNLSETAEIDFRLLIQNKsltgiKRFVADNPSTLDDfilvlprlfgpatailkqAKNLTTDKgILT----- 235
Cdd:CHL00201 169 KLEDRQSYQLKLVEYLSQYQDDLDTDS-----QNRLYSNPIRILD------------------SKNLKTQE-ILDgapki 224

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502716242 236 ----ALREMETIVEAVSYTADISV----DLGLVQDFHYYTGIIF--RGYADLAADNFLSGGRYDHLLEQFTSASSPAVGL 305
Cdd:CHL00201 225 sdflSLESTEHFYDVCTYLNLLNIpykiNYKLVRGLDYYNDTAFeiKTLSSNGQDTICGGGRYDSLIHQLGGPKTPAVGC 304


                 ....*..
gi 502716242 306 ALNLDSL 312
Cdd:CHL00201 305 AIGLERL 311
PLN02530 PLN02530
histidine-tRNA ligase
 6-304 1.50e-15

histidine-tRNA ligase


Pssm-ID: 178145 [Multi-domain]  Cd Length: 487  Bit Score: 77.86  E-value: 1.50e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502716242   6 NLPTGTRD------KL-------FREARAAYkieqqvnhyfekrGFKRIETPVIEFEDVF---SSEHQADaKLYRFFDEK 69
Cdd:PLN02530  71 NPPKGTRDfppedmRLrnwlfdhFREVSRLF-------------GFEEVDAPVLESEELYirkAGEEITD-QLYNFEDKG 136

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502716242  70 GRLTVLRPDMTLPIGRVVSTTG--VMLPLKLSYSGKIFRANEDFGGEQNEQTQAGIEIIGYPSIKAEIECIL-------- 139
Cdd:PLN02530 137 GRRVALRPELTPSLARLVLQKGksLSLPLKWFAIGQCWRYERMTRGRRREHYQWNMDIIGVPGVEAEAELLAaivtffkr 216

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502716242 140 IGI----------------GVLNALEIPN--F--------QIE-LGHAAIYRRVTNLLNLSETAEidfrLLIQNKSLTgi 192
Cdd:PLN02530 217 VGItssdvgikvssrkvlqAVLKSYGIPEesFapvcvivdKLEkLPREEIEKELDTLGVSEEAIE----GILDVLSLK-- 290

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502716242 193 krfvadnpsTLDDfilvLPRLFGPATAILKQaknlttdkgiltaLREMETIVEAVSYTADISVDLGLVQDFHYYTGIIFR 272
Cdd:PLN02530 291 ---------SLDD----LEALLGADSEAVAD-------------LKQLFSLAEAYGYQDWLVFDASVVRGLAYYTGIVFE 344

                        330       340       350
                 ....*....|....*....|....*....|....*
gi 502716242 273 GY---ADLAAdnFLSGGRYDHLLEQFTSASSPAVG 304
Cdd:PLN02530 345 GFdraGKLRA--ICGGGRYDRLLSTFGGEDTPACG 377
hisZ PRK12293
ATP phosphoribosyltransferase regulatory subunit; Provisional
 1-312 7.64e-13

ATP phosphoribosyltransferase regulatory subunit; Provisional


Pssm-ID: 183411  Cd Length: 281  Bit Score: 68.10  E-value: 7.64e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502716242   1 MNLNKNLPTGTRDKLFREARAAYKIEQQVNHYFEKRGFKRIETPVIEFedvfsSEHQADA---KLYRFFDEKGRLTVLRP 77
Cdd:PRK12293   1 MILEHEIPQGSKLYFGKSAKLKREIENVASEILYENGFEEIVTPFFSY-----HQHQSIAdekELIRFSDEKNHQISLRA 75

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502716242  78 DMTLPIGRVV------STTgvmlPLKLSYSGKIFRAnedfggEQNEQTQAGIEIIGYPSIKaeiECILIGIGVLNALEI- 150
Cdd:PRK12293  76 DSTLDVVRIVtkrlgrSTE----HKKWFYIQPVFRY------PSNEIYQIGAELIGEEDLS---EILNIAAEIFEELELe 142

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502716242 151 PNFQIElgHAAIYRRVTNLLNLS----ETAEIDfRLLIQN----KSLTGIKrfvadNPSTLDDFILVLPrlfgpatAILK 222
Cdd:PRK12293 143 PILQIS--NIKIPKLVAEILGLDievfKKGQIE-KLLAQNvpwlNKLVRIK-----TLEDLDEVIELVP-------DEIK 207

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502716242 223 QaknlttdkgiltALREMETIVEAVSYTADISVDLGLVQdFHYYTGIIFRgyadLAADNF--LSGGRYDhlleqftSASS 300
Cdd:PRK12293 208 E------------ELEKLKELAESIKYENLVIAPLYYAK-MRYYDDLFFR----FFDGNStlASGGNYE-------IDGI 263

                        330
                 ....*....|..
gi 502716242 301 PAVGLALNLDSL 312
Cdd:PRK12293 264 SSSGFALYTDNL 275
class_II_aaRS-like_core cd00768
Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA ...
 23-142 2.09e-06

Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it attaches the amino acid at the 2'-OH group, like class I aaRSs. These enzymes are usually homodimers. This domain is primarily responsible for ATP-dependent formation of the enzyme bound aminoacyl-adenylate. The substrate specificity of this reaction is further determined by additional domains. Intererestingly, this domain is also found is asparagine synthase A (AsnA), in the accessory subunit of mitochondrial polymerase gamma and in the bacterial ATP phosphoribosyltransferase regulatory subunit HisZ.


Pssm-ID: 238391 [Multi-domain]  Cd Length: 211  Bit Score: 48.27  E-value: 2.09e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502716242  23 YKIEQQVNHYFEKRGFKRIETPVIEFEDVFSSEHQADAKLYRFFDEKGRLTVLRPDMTLPIGRVVSTTGVMLPLKLSYSG 102
Cdd:cd00768    3 SKIEQKLRRFMAELGFQEVETPIVEREPLLEKAGHEPKDLLPVGAENEEDLYLRPTLEPGLVRLFVSHIRKLPLRLAEIG 82

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|..
gi 502716242 103 KIFRANED--FGGEQNEQTQAGIEIIGYPSIKAEIECILIGI 142
Cdd:cd00768   83 PAFRNEGGrrGLRRVREFTQLEGEVFGEDGEEASEFEELIEL 124
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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