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Conserved domains on  [gi|502716545|ref|WP_012951558|]
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MULTISPECIES: phage holin [Listeria]

Protein Classification

COG5546 family protein( domain architecture ID 10009421)

COG5546 family protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
COG5546 COG5546
Uncharacterized membrane protein [Function unknown];
2-85 1.54e-30

Uncharacterized membrane protein [Function unknown];


:

Pssm-ID: 444289  Cd Length: 87  Bit Score: 102.74  E-value: 1.54e-30
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502716545  2 KINWKVRFKNKTWVIAMIAAVFFIIQAVLLVFNVTWDYNELLKQL---ITVITGVFAAWGLIIDPTTAGSKDSAQAQEYT 78
Cdd:COG5546   1 KINWKVRLKNKAFWVALIGAILLLAQQVLGLFGIDLDIASLLEQLtdiVNAVFAILVLLGVIVDPTTKGISDSEQALTYN 80


                ....*..
gi 502716545 79 EPRKDDK 85
Cdd:COG5546  81 KPRKDDK 87
 
Name Accession Description Interval E-value
COG5546 COG5546
Uncharacterized membrane protein [Function unknown];
2-85 1.54e-30

Uncharacterized membrane protein [Function unknown];


Pssm-ID: 444289  Cd Length: 87  Bit Score: 102.74  E-value: 1.54e-30
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502716545  2 KINWKVRFKNKTWVIAMIAAVFFIIQAVLLVFNVTWDYNELLKQL---ITVITGVFAAWGLIIDPTTAGSKDSAQAQEYT 78
Cdd:COG5546   1 KINWKVRLKNKAFWVALIGAILLLAQQVLGLFGIDLDIASLLEQLtdiVNAVFAILVLLGVIVDPTTKGISDSEQALTYN 80


                ....*..
gi 502716545 79 EPRKDDK 85
Cdd:COG5546  81 KPRKDDK 87
Phage_holin_1 pfam04531
Bacteriophage holin; This family of holins is found in several staphylococcal and ...
 3-81 2.99e-23

Bacteriophage holin; This family of holins is found in several staphylococcal and streptococcal bacteriophages. Holins are a diverse family of proteins that cause bacterial membrane lysis during late-protein synthesis. It is thought that the temporal precision of holin-mediated lysis may occur through the buildup of a holin oligomer which causes the lysis.


Pssm-ID: 398297  Cd Length: 82  Bit Score: 84.29  E-value: 2.99e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502716545   3 INWKVRFKNKTWVIAMIAAVFFIIQAVLLVFNV---TWDYNELLKQLITVITGVFAAWGLIIDPTTAGSKDSAQAQEYTE 79
Cdd:pfam04531  1 INWKVRFKNKVFWVALISAVLLPILAYLGLFGIdltVWKLGEQLMQAVNAVLSLLNALGVITDPTTKGISDSEQALTYEE 80


                 ..
gi 502716545  80 PR 81
Cdd:pfam04531 81 PK 82
holin_phiLC3 TIGR01598
holin, phage phi LC3 family; Phage proteins for bacterial lysis typically include a ...
 3-79 1.26e-21

holin, phage phi LC3 family; Phage proteins for bacterial lysis typically include a membrane-disrupting protein, or holin, and one or more cell wall degrading enzymes that reach the cell wall because of holin action. Holins are found in a large number of mutually non-homologous families. [Mobile and extrachromosomal element functions, Prophage functions]


Pssm-ID: 130659  Cd Length: 78  Bit Score: 79.87  E-value: 1.26e-21
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 502716545   3 INWKVRFKNKTWVIAMIAAVFFIIQAVLLVFNVTW-DYNELLKQLITVITGVFAAWGLIIDPTTAGSKDSAQAQEYTE 79
Cdd:TIGR01598  1 INWKVRLKNKATLIALLGALFLAIQSILDNFGVLWlSFNRQLNAPIAAITTILAVVGIIMDPTTSGLSDSLRVQNYSE 78
 
Name Accession Description Interval E-value
COG5546 COG5546
Uncharacterized membrane protein [Function unknown];
2-85 1.54e-30

Uncharacterized membrane protein [Function unknown];


Pssm-ID: 444289  Cd Length: 87  Bit Score: 102.74  E-value: 1.54e-30
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502716545  2 KINWKVRFKNKTWVIAMIAAVFFIIQAVLLVFNVTWDYNELLKQL---ITVITGVFAAWGLIIDPTTAGSKDSAQAQEYT 78
Cdd:COG5546   1 KINWKVRLKNKAFWVALIGAILLLAQQVLGLFGIDLDIASLLEQLtdiVNAVFAILVLLGVIVDPTTKGISDSEQALTYN 80


                ....*..
gi 502716545 79 EPRKDDK 85
Cdd:COG5546  81 KPRKDDK 87
Phage_holin_1 pfam04531
Bacteriophage holin; This family of holins is found in several staphylococcal and ...
 3-81 2.99e-23

Bacteriophage holin; This family of holins is found in several staphylococcal and streptococcal bacteriophages. Holins are a diverse family of proteins that cause bacterial membrane lysis during late-protein synthesis. It is thought that the temporal precision of holin-mediated lysis may occur through the buildup of a holin oligomer which causes the lysis.


Pssm-ID: 398297  Cd Length: 82  Bit Score: 84.29  E-value: 2.99e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502716545   3 INWKVRFKNKTWVIAMIAAVFFIIQAVLLVFNV---TWDYNELLKQLITVITGVFAAWGLIIDPTTAGSKDSAQAQEYTE 79
Cdd:pfam04531  1 INWKVRFKNKVFWVALISAVLLPILAYLGLFGIdltVWKLGEQLMQAVNAVLSLLNALGVITDPTTKGISDSEQALTYEE 80


                 ..
gi 502716545  80 PR 81
Cdd:pfam04531 81 PK 82
holin_phiLC3 TIGR01598
holin, phage phi LC3 family; Phage proteins for bacterial lysis typically include a ...
 3-79 1.26e-21

holin, phage phi LC3 family; Phage proteins for bacterial lysis typically include a membrane-disrupting protein, or holin, and one or more cell wall degrading enzymes that reach the cell wall because of holin action. Holins are found in a large number of mutually non-homologous families. [Mobile and extrachromosomal element functions, Prophage functions]


Pssm-ID: 130659  Cd Length: 78  Bit Score: 79.87  E-value: 1.26e-21
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 502716545   3 INWKVRFKNKTWVIAMIAAVFFIIQAVLLVFNVTW-DYNELLKQLITVITGVFAAWGLIIDPTTAGSKDSAQAQEYTE 79
Cdd:TIGR01598  1 INWKVRLKNKATLIALLGALFLAIQSILDNFGVLWlSFNRQLNAPIAAITTILAVVGIIMDPTTSGLSDSLRVQNYSE 78
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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