|
Name |
Accession |
Description |
Interval |
E-value |
| ampG |
PRK11010 |
muropeptide MFS transporter AmpG; |
1-499 |
0e+00 |
|
muropeptide MFS transporter AmpG;
Pssm-ID: 182898 [Multi-domain] Cd Length: 491 Bit Score: 847.00 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502753160 1 MTNHYLNkLSTLRNYYILLLLGFASGLPLALTGGTLQAWMTIENLDIKTIGFFTLVGQAYVFKFLWAPAMDRYSPSFLGR 80
Cdd:PRK11010 1 MSSQYLR-IFQQPNSAILLILGFASGLPLALTSGTLQAWMTVENIDLKTIGFFSLVGQAYVFKFLWSPLMDRYTPPFLGR 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502753160 81 RRGWMLVTQLLLIVSIATMAFLKPSEHLWWLAALAVSVAFFSASQDIIFDAYKTDLLSQEERGSGAAISVLGYRIAMLVS 160
Cdd:PRK11010 80 RRGWLLATQLLLLVAIAAMGFLEPGTQLRWLAALAVVIAFCSASQDIVFDAWKTDVLPAEERGAGAAISVLGYRLAMLVS 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502753160 161 GGLALWLTT-YIGWQNMYLIMAGMMLIGVYATLTAKEPKINTAPPKTLHQAVLEPLSDFFSRNNAWLILLLIVLYKLADA 239
Cdd:PRK11010 160 GGLALWLADrYLGWQGMYWLMAALLIPCIIATLLAPEPTDTIPVPKTLEQAVVAPLRDFFGRNNAWLILLLIVLYKLGDA 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502753160 240 FALSLSTTFLIRGVGFTAAEVGMINKTLGLAATIVGALYGGYLMHKWSLFRALMIFGILQTVSNLSYWILAVTPKDIYVM 319
Cdd:PRK11010 240 FAMSLTTTFLIRGVGFDAGEVGLVNKTLGLLATIVGALYGGILMQRLSLFRALMIFGILQGVSNAGYWLLSITDKNLYSM 319
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502753160 320 GGAVFLENICGGMGTAAFVALLMTLCNKSFSATQFALLSALAAIGRVYVGPVAGWFAESHGWPMFYLFSIFIGLPGLWLL 399
Cdd:PRK11010 320 GAAVFFENLCGGMGTAAFVALLMTLCNKSFSATQFALLSALSAVGRVYVGPVAGWFVEAHGWPTFYLFSVAAAVPGLLLL 399
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502753160 400 FICRNTLTYTEKNDNFISRTLFKSYYRIAFIIMLLAASIFIIWlicscliiIISSITHFIVLDGLQKAISPVFSFSIAMG 479
Cdd:PRK11010 400 LVCRQTLEYTQKTDNFIPRTEYPAGYRFALRLLLAGVSLLAVW--------LLLLTMNALDLTHFSFLPATLLEVGVLVA 471
|
490 500
....*....|....*....|
gi 502753160 480 TVGLLLGGALDYLALRKTKF 499
Cdd:PRK11010 472 LSGIVLGGLLDYLALRKTHL 491
|
|
| ampG |
PRK11902 |
muropeptide transporter; Reviewed |
18-406 |
0e+00 |
|
muropeptide transporter; Reviewed
Pssm-ID: 183369 [Multi-domain] Cd Length: 402 Bit Score: 535.20 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502753160 18 LLLLGFASGLPLALTGGTLQAWMTIENLDIKTIGFFTLVGQAYVFKFLWAPAMDRYSPSFLGRRRGWMLVTQLLLIVSIA 97
Cdd:PRK11902 4 MLLLGFASGLPLALTSGTLQAWMTVEGLDIQTIGFFSLVGQAYIFKFLWAPLMDRYTPPLLGRRRGWLLLTQVGLAASIA 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502753160 98 TMAFLKPSEHLWWLAALAVSVAFFSASQDIIFDAYKTDLLSQEERGSGAAISVLGYRIAMLVSGGLALWLTT-YIGWQNM 176
Cdd:PRK11902 84 AMAFCPPHAALWPLAGLAVLVAFLSASQDIVFDAYSTDVLHPEERGAGAAVKVLGYRLAMLVSGGLALWLADrVLGWGNT 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502753160 177 YLIMAGMMLIGVYATLTAKEPKINTAPPKTLHQAVLEPLSDFFSRNNAWLILLLIVLYKLADAFALSLSTTFLIRGVGFT 256
Cdd:PRK11902 164 YLLMAGLMLAGALTTLWAPEPEVPARPPRSLGEAVVGPLRDFFSRRGAWALLLLIVLYKLGDAFAGSLSTTFLIRGAGFS 243
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502753160 257 AAEVGMINKTLGLAATIVGALYGGYLMHKWSLFRALMIFGILQTVSNLSYWILAVTPKDIYVMGGAVFLENICGGMGTAA 336
Cdd:PRK11902 244 AGEVGIVNKTLGLAATIVGALAGGTLMVRLGLYRSLMLFGVLQAVSNLGYWVLAVTPKHLWTMALAIGIENLCGGMGTAA 323
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502753160 337 FVALLMTLCNKSFSATQFALLSALAAIGRVYVGPVAGWFAESHGWPMFYLFSIFIGLPGLWLLFICRNTL 406
Cdd:PRK11902 324 FVALLMALCNRSFSATQYALLSALASVGRVYVGPTSGYLVEAYGWPGFYLMTVVIALPGLALLWLMRGTI 393
|
|
| MFS_AmpG_like |
cd17486 |
AmpG and similar transporters of the Major Facilitator Superfamily; AmpG acts as an inner ... |
18-400 |
6.83e-142 |
|
AmpG and similar transporters of the Major Facilitator Superfamily; AmpG acts as an inner membrane permease in the beta-lactamase induction system and in peptidoglycan recycling. It transports meuropeptide from the periplasm into the cytosol in gram-negative bacteria, which is essential for the induction of the ampC encoding beta-lactamase. The AmpG family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341039 [Multi-domain] Cd Length: 387 Bit Score: 413.15 E-value: 6.83e-142
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502753160 18 LLLLGFASGLPLALTGGTLQAWMTIENLDIKTIGFFTLVGQAYVFKFLWAPAMDRYSPSFLGRRRGWMLVTQLLLIVSIA 97
Cdd:cd17486 1 ILLLGFASGLPYLLTGTTLQAWLKEAGVDLDTIGLFSLVGLPYSLKFLWAPLVDRYSTPFLGRRRGWILLTQILLMAALI 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502753160 98 TMAFLKPSEHLWWLAALAVSVAFFSASQDIIFDAYKTDLLSQEERGSGAAISVLGYRIAMLVSGGLALWLTTYIGWQNMY 177
Cdd:cd17486 81 ALAFLDPFTNLVLSALLFLLVAFFSATQDIAIDAYRIEALEDKEQGAGAGVRVNGYRIGMLVAGAGALYLADSLSWSAVY 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502753160 178 LIMAGMMLIGVYATLTAKEPKINTAPPKTLHQ---AVLEPLSDFFSRNNAWLILLLIVLYKLADAFALSLSTTFLIRGvG 254
Cdd:cd17486 161 LIMAALMGPGILATLFAPEPPRTDPPANSLSEtvvAFFAPFKDFFGQPGALLILAFILLYKLGDAMLGAMATPFLLDL-G 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502753160 255 FTAAEVGMINKTLGLAATIVGALYGGYLMHKWSLFRALMIFGILQTVSNLSYWILAVTPKDIYVMGGAVFLENICGGMGT 334
Cdd:cd17486 240 FTKTEIGAVYKTVGLIATIVGGLLGGFLMSRLGLKRSLWLFGILQALSNLGFIYLAHAGPNLTLLVAAVAVENFGGGLGT 319
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 502753160 335 AAFVALLMTLCNKSFSATQFALLSALAAIGRVYVGPVAGWFAESHGWPMFYLFSIFIGLPGLWLLF 400
Cdd:cd17486 320 TAFVAYLMSLCNGEFTATQYALLSSLMALGRMVLGAPSGWLAEALGWTGFFLLTTLAAIPGLLLLL 385
|
|
| 2A0125 |
TIGR00901 |
AmpG-like permease; [Cellular processes, Adaptations to atypical conditions] |
26-363 |
1.89e-103 |
|
AmpG-like permease; [Cellular processes, Adaptations to atypical conditions]
Pssm-ID: 273329 [Multi-domain] Cd Length: 356 Bit Score: 313.56 E-value: 1.89e-103
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502753160 26 GLPLALTGGTLQAWMTIENLDIKTIGFFTLVGQAYVFKFLWAPAMDRYSPSFLGRRRGWMLVTQLLLIVSIATMAFLKPS 105
Cdd:TIGR00901 1 GLPLGLVGNTLPYWLRSKNVSLKTIGFFSLVGLPYSLKFLWSPLVDTVYLPFFGRRRSWLVLTQVLLLSLLLILSFLVPS 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502753160 106 EHLWWLAALAVSVAFFSASQDIIFDAYKTDLLSQEERGSGAAISVLGYRIAMLVSGGLALWLTTY--------IGWQNMY 177
Cdd:TIGR00901 81 TDLPLLAGLAFLIAFFSATQDIALDAWRLEILSDEELGYGSTIYIVGYRAGMLLSGSLALVLASPefantgliTLWGYIF 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502753160 178 LIMAGMMLIGVYATLT-AKEPKINTAPPKTLHQAVLEPLSDFFSRNN---AWLILLLIVLYKLADAFALSLSTTFLIRgV 253
Cdd:TIGR00901 161 FWTALLILPGLLVTLFlAKEPQEDASVPKPLTQAVLKPIREFFQRKNmiqALLLLLLIVLYKLGDSAATVLTTLFLLD-M 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502753160 254 GFTAAEVGMINKTLGLAATIVGALYGGYLMHKWSLFRALMIFGILQTVSNLSYWILA-------VTPKDIYVMGGAVFLE 326
Cdd:TIGR00901 240 GFSKEEIALVAKINGLLGAILGGLIGGIIMQPLNILYALLLFGIVQALTNAGFVWLAsnghhdgITFPHLLMLFLTITLE 319
|
330 340 350
....*....|....*....|....*....|....*..
gi 502753160 327 NICGGMGTAAFVALLMTLCNKSFSATQFALLSALAAI 363
Cdd:TIGR00901 320 AVTGGLGTVAFVAFLSKLSNPKFGATQMALLSSLSAL 356
|
|
| MFS_MFSD3 |
cd17485 |
Major facilitator superfamily domain containing 3 protein; Major facilitator superfamily ... |
17-399 |
1.98e-67 |
|
Major facilitator superfamily domain containing 3 protein; Major facilitator superfamily domain containing 3 protein (MFSD3) is a predicted acetyl-CoA transporter. As an atypical putative membrane-bound solute carrier (SLC), MFSD3 is most likely to be functionally active in the plasma membrane and not in any intracellular organelles. MFSD3 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341038 [Multi-domain] Cd Length: 386 Bit Score: 221.72 E-value: 1.98e-67
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502753160 17 ILLLLGFASGLPLALTGGTLQAWMTIENLDIKTIGFFTLVGQAYVFKFLWAPAMDRYSPSFLGRRRGWMLVTQLLLIVSI 96
Cdd:cd17485 1 LLFGLYLAQGLPYGFQSQALPVLLRSAGVSLTAIGLLKLLYLPWVLKFLWAPLVDRYGLPRLGRRRSWLLPTQLGLALLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502753160 97 ATMAFLKPSEHLWWLAALAVSVAFFSASQDIIFDAYKTDLLSQEERGSGAAISVLGYRIAMLVSGGLALWLTTYIGWQNM 176
Cdd:cd17485 81 LALAFLPPTTNLLAFLGLLFLLNLFSATQDIATDGLAVELLTPEERGLGNAAQVVGYKLGSLLGGGGLLWLYDLIGWQSL 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502753160 177 YLIMAGMMLIGVYATLTAKEPKINTAPPKTLHQAVLEP-LSDFFSRNNAWLILLLIVLYKLADAFALSLSTTFLIrGVGF 255
Cdd:cd17485 161 LLSLAALYLLLLLPVLFLRELELPQQPPASERGAALKAsLRAFLRRPGTRWLLLFLLLYKLGEQGALAMLPPFLV-DRGF 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502753160 256 TAAEVGMINKTLGLAATIVGALYGGYLMHKWSLFRALMIFGILQTVSNLSYWILAV--TPKDIYVMGGAVFLENICGGMG 333
Cdd:cd17485 240 SLSQIGLLSGVGGSLVSIAGSLLGGYLLKRRGRRRLLLLGGLLRLLLLGLYTLLALggSGLNWVLLLASLALLHLVGGMI 319
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 502753160 334 TAAFVALLMTLCNKSFSATQFALLSALAAIGRVYVGPVAGWFAESHGWPMFYLFSIFIGLPGLWLL 399
Cdd:cd17485 320 TTALFTLMMDCSQQAQAGTDYTLLATVEVLGKLLFGSLAGFLADHLGYAAAFLLFAILSALSVLLL 385
|
|
| sider_RhtX_FptX |
TIGR02718 |
siderophore transporter, RhtX/FptX family; RhtX from Sinorhizobium meliloti 2011 and FptX from ... |
13-398 |
3.71e-31 |
|
siderophore transporter, RhtX/FptX family; RhtX from Sinorhizobium meliloti 2011 and FptX from Pseudomonas aeruginosa appear to be single polypeptide transporters, from the major facilitator family (see pfam07690) for import of siderophores as a means to import iron. This function was suggested by proximity to siderophore biosynthesis genes and then confirmed by study of knockout and heterologous expression phenotypes. [Transport and binding proteins, Cations and iron carrying compounds]
Pssm-ID: 131765 Cd Length: 390 Bit Score: 124.24 E-value: 3.71e-31
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502753160 13 RNYYILLLLGFASGLPLALTGGTLQAWMTIENLDIKTIGFFTLVGQAYVFKFLWAPAMDRYSPSFLGRRRGWMLVTQLLL 92
Cdd:TIGR02718 1 RLVITLGLLYLSQGIPIGLAMDALPTLLREDGAPLTALAFLPLVGLPWVVKFLWAPLVDNWWSWRLGRRRSWVLPMQCLV 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502753160 93 IVSIATMAFLKPS-EHLWWLAALAVSVAFFSASQDIIFDAYKTDLLSQEERGSGAAISVLGYRIAMLVSGGLALWLTTYI 171
Cdd:TIGR02718 81 SACLASLALVGPDvAGAGWAVGLLACASLASATQDIATDGMAAEHFNGRTLAKGNAVQIAGVMIGFFGGGAGTLVLFGKF 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502753160 172 GWQNMYLIMAGMMLIGVYATLTAKEPKINTAPPKTLHQAvlePLSDFFSRNNAWLILLLIVLYKLADAFALSLSTTFLIR 251
Cdd:TIGR02718 161 GQRPAFLLVACVPLASLVCVLWLKDRAVASPEAPLARRA---SLFRFFRRPLAWSLLALALLSAMTAVSGFGLSKLYLVD 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502753160 252 GvGFTAAEVGMINKTLGLAATIVGALYGGYLMHKWSLFRALMIFGILQTVSNLSYWILA---VTPKDIYVMGGAVFLENI 328
Cdd:TIGR02718 238 A-GWPLEWIGRLGMAGGAVTVLLGCGGGAWLVRRAGLWRTFILGVGLAGSLALLWFAQAafwLAPGIAVAWSCSAFGSLI 316
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502753160 329 CGGMGTAAFVALLMTLCNKSFSATQFALLSALAAIGRVYVGPVAGWFAESHGWPMFYLFSIFIGLPGLWL 398
Cdd:TIGR02718 317 TGITSVAIYTAFMRFAGDGDQAGTDVTAVQSTRDLGELIASSIAGYLTDRFGYAGGFLSGTVLAVLAILL 386
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
18-400 |
4.50e-14 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 73.61 E-value: 4.50e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502753160 18 LLLLGFASGLPLALTGGTLQAWMTIENLDIKTIGFFTLVGQ--AYVFKFLWAPAMDRYspsflgRRRGWMLVTQLLLIVS 95
Cdd:cd06174 1 LLLGFFLTGLARGLISPLLPALLQSFGLSASQLGLLFALFSlgYALLQPLAGLLADRF------GRRPVLLLGLLLFALG 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502753160 96 IATMAFlkpSEHLWWLAALAVSVAFFSASQDIIFDAYKTDLLSQEERGSGAAISVLGYRIAMLVSGGLALWLTTYI--GW 173
Cdd:cd06174 75 ALLFAF---APSFWLLLLGRFLLGLGSGLIDPAVLALIADLFPERERGRALGLLQAFGSVGGILGPLLGGILASSLgfGW 151
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502753160 174 QNMYLIMAGMMLIGVYATLTAKEPKINTAPPKT---LHQAVLEPLSDFFSRNNAWLILLLIVLYKLADAFALSLSTTFLI 250
Cdd:cd06174 152 RAVFLIAAALALLAAILLLLVVPDPPESARAKNeeaSSKSVLKLLKRVLKNPGLWLLLLAIFLVNLAYYSFSTLLPLFLL 231
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502753160 251 RGVGFTAAEVGMINKTLGLAATIVGALYGGYLMHKWSLFRALMIFGILQTVSNLSYWILAVTpkdiYVMGGAVFLENICG 330
Cdd:cd06174 232 DLGGLSVAVAGLLLSLFGLAGALGSLLLGLLSDRLIGRKPLLLIGLLLMALGLALLLLAPSL----LLLLLLLLLLGFGL 307
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 502753160 331 GMGTAAFVALLMTLCNKSFSATQFALLSALAAIGRVYVGPVAGWF-AESHGWPMFYLFSIFIGLPGLWLLF 400
Cdd:cd06174 308 GGLLPLSFALIAELFPPEIRGTAFGLLNTFGFLGGAIGPLLAGFLlAATFGLTGAFLVLAVLLLLAAILLL 378
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
17-364 |
1.89e-13 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 71.54 E-value: 1.89e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502753160 17 ILLLLGFASGLPLALTGGTLQAWMTIENLDIKTIGFFTLVGQ--AYVFKFLWAPAMDRYSpsflgrRRGWMLVTQLLLIV 94
Cdd:COG2814 14 ALALGAFLSGLGIGIVLPALPLIAADLGASPAQAGLVVTAYLlgAALGAPLAGRLADRFG------RRRVLLLGLLLFAL 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502753160 95 SIATMAFlkpSEHLWWLAALAVSVAFFSASQDIIFDAYKTDLLSQEERGSGAAISVLGYRIAMLVSGGLALWLTTYIGWQ 174
Cdd:COG2814 88 GSLLCAL---APSLWLLLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLADLFGWR 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502753160 175 NMYLIMAGMMLIGVYATLTAKEpkintAPPKTLHQAVLEPLSDFFSRNNAWLILLLIVLYKLADAFALSLSTTFLIRGVG 254
Cdd:COG2814 165 WVFLVNAVLALLALLLLLRLLP-----ESRPAARARLRGSLRELLRRPRLLLLLLLAFLLGFGFFALFTYLPLYLQEVLG 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502753160 255 FTAAEVGMINkTLGLAATIVGALYGGYLMHKWSLFRALMIFGILQTVSnlsyWILAVTPKDIYVMGGAVFLENICGGMGT 334
Cdd:COG2814 240 LSASAAGLLL-ALFGLGGVLGALLAGRLADRFGRRRLLLIGLLLLALG----LLLLALAGSLWLLLLALFLLGFGFGLLF 314
|
330 340 350
....*....|....*....|....*....|
gi 502753160 335 AAFVALLMTLCNKSFSATQFALLSALAAIG 364
Cdd:COG2814 315 PLLQALVAELAPPEARGRASGLYNSAFFLG 344
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
61-366 |
4.49e-13 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 70.14 E-value: 4.49e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502753160 61 VFKFLWAPAMDRYSpsflgrRRGWMLVTQLLLIVSIATMAFlkpSEHLWWLAALAVSVAFFSASQDIIFDAYKTDLLSQE 140
Cdd:pfam07690 47 LAQPLAGRLSDRFG------RRRVLLIGLLLFALGLLLLLF---ASSLWLLLVLRVLQGLGAGALFPAALALIADWFPPE 117
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502753160 141 ERGSGAAISVLGYRIAMLVSGGLALWLTTYIGWQNMYLIMAGMMLIGVYATLTAKEPKINTAPPKTLHQAVLEPLSDFFS 220
Cdd:pfam07690 118 ERGRALGLVSAGFGLGAALGPLLGGLLASLFGWRAAFLILAILSLLAAVLLLLPRPPPESKRPKPAEEARLSLIVAWKAL 197
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502753160 221 RNNAWLILLLIVLYKLADAFALSLSTTFLIRGVGFTAAEVGMInKTLGLAATIVGALYGGYLMHKWSLFRALMIFGILQT 300
Cdd:pfam07690 198 LRDPVLWLLLALLLFGFAFFGLLTYLPLYQEVLGLSALLAGLL-LGLGGLLGAIGRLLLGRLSDRLGRRRRLLLALLLLI 276
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 502753160 301 VSNLSYWILAVTpKDIYVMGGAVFLENICGGMGTAAFVALLMTLCNKSFSATQFALLSALAAIGRV 366
Cdd:pfam07690 277 LAALGLLLLSLT-LSSLWLLLALLLLGFGFGLVFPALNALVSDLAPKEERGTASGLYNTAGSLGGA 341
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
78-401 |
1.43e-12 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 69.14 E-value: 1.43e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502753160 78 LGRRRgWMLVTQLLLIVSIATMAFLKPsehLWWLAALAVSVAFFSASQDIIFDAYKTDLLSQEERGSGAAISVLGYRIAM 157
Cdd:COG2223 67 FGPRR-VLLIGLLLLGIGLLLLALAVS---YWLLLLLGLLLGIGGGGSFAVGIALVSKWFPPDRRGLALGLAAGGGNLGA 142
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502753160 158 LVSGGLALWLTTYIGWQNMYLIMAGMMLIG--VYATLTAKEPKINTAPPKTLHQAVLEPLSDFfsrnNAWLILLLIVLYK 235
Cdd:COG2223 143 AVAAFLAPLLIAAFGWRNAFLILGILLLVVavLAWLFLRDPPAGAAAAAKASLRDQLEALRDP----RFWLLSLLYFGTF 218
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502753160 236 LADAFALSLSTTFLIRGVGFTAAEVGMINkTLGLAATIVGALYGGYLMHKWSLFRALMIFGILQTVsnlSYWILAVTPKD 315
Cdd:COG2223 219 GSFIGFSSWLPPYLVDQFGLSAATAGLLA-ALFALLGALGRPLGGWLSDRIGGRRVLLIVFALMAL---GLLLLALALGS 294
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502753160 316 IYVMGGAVFLENICGGMGTAAFVALLMTLCNKSFSATQFALLSALAAIGRVYVGPVAGWFAESHG--WPMFYLFSIFIGL 393
Cdd:COG2223 295 LWLFLVLFLLLGLALGGGNGAVFALVPDIFPTKNAGAVYGLVGAAGGLGGFLGPLLFGALLDATGsyTAAFLVFAVLALV 374
|
....*...
gi 502753160 394 PGLWLLFI 401
Cdd:COG2223 375 ALVLTLLL 382
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
76-342 |
2.05e-11 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 65.69 E-value: 2.05e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502753160 76 SFLGRRRGWMLVTQLLLIVSIATMAFLKPSEH---LWWLAALAVSVAFFSASQDIIFDAYKTDLL-SQEERGSGAAISVL 151
Cdd:COG2211 75 TRWGRRRPWILIGAIPLALSFVLLFTAPDLSPtgkLIYALVTYLLLGLAYTLVNIPYSALGAELTpDYEERTRLSSWRFA 154
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502753160 152 GYRIAMLVSGGLALWLTTYI------GWQNMYLIMAGMMLIGVYAT-LTAKEPKINTAPPKTLHQAvlepLSDFFSRNNA 224
Cdd:COG2211 155 FAGLGGLLASVLPPPLVAAFggdaalGYRLTALIFAVLGLLAFLLTfFGTKERPVPEEEKVSLKES----LKALLKNRPF 230
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502753160 225 WLILLLIVLYKLADAFALSLSTTFLIRGVGFTAAEVGMINkTLGLAATIVGALYGGYLMHKWSLFRALMIFGILQTVSNL 304
Cdd:COG2211 231 LLLLLAYLLFFLALALVAALLLYYFKYVLGLSAALVGLLL-ALYFLAALLGAPLWPRLAKRFGKKKAFIIGLLLAALGLL 309
|
250 260 270
....*....|....*....|....*....|....*...
gi 502753160 305 SYWILavTPKDIYVMGGAVFLENICGGMGTAAFVALLM 342
Cdd:COG2211 310 LLFFL--GPGNLWLLLVLAALAGIGLGAILVLPWAMLA 345
|
|
| MFS_MefA_like |
cd06173 |
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ... |
80-401 |
3.62e-10 |
|
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340863 [Multi-domain] Cd Length: 383 Bit Score: 61.48 E-value: 3.62e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502753160 80 RRRGWMLVTQLLLIVSIATMAFL--KPSEHLWWLAALAVSVAFFSASQDIIFDAYKTDLLSQEERGSGAAISVLGYRIAM 157
Cdd:cd06173 62 DRRRLLILADLLRALLAAVLALLalLGSLSLWLLLVLAFLLGIASAFFGPARQALLPELVPKEQLVRANALNSLATQLAR 141
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502753160 158 LVSGGLALWLTTYIGWQNMYLIMAGMMLIG--VYATLTAKEPKINTAPPKTLHQAVLEPLSDFFSRNNAWLILLLIVLYK 235
Cdd:cd06173 142 IIGPALGGLLVALLGPGGAFAINALSFLLSalLLLFIRRPPPAAPGESSSLLLRDLREGLRYLRRSPLLRLLLLALALFA 221
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502753160 236 LADAFALSLSTTFLIRGVGFTAAEVGMINKTLGLAAtIVGALYGGYLMHKWSLFRALMIFGILQTvsnLSYWILAVTPkD 315
Cdd:cd06173 222 LLGGALTVLLPLLAKEVLGGGAAGYGLLLAAFGVGA-LLGALLLGRLSKRRRRGRLLLIGALLLG---LALLVLGLSP-S 296
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502753160 316 IYVMGGAVFLENICGGMGTAAFVALLMTLCNKSFSATQFALLSALAAIGRVYVGPVAGWFAESHGWPM-FYLFSIFIGLP 394
Cdd:cd06173 297 LWLLLAALFLLGLAGGLFNVPLNTLLQLRVPDELRGRVFSVYNALNSGAMPLGALLAGLLADALGLSAvFLLAGALLLLA 376
|
....*..
gi 502753160 395 GLWLLFI 401
Cdd:cd06173 377 ALLLLLL 383
|
|
| FucP |
COG0738 |
Fucose permease [Carbohydrate transport and metabolism]; |
7-403 |
5.17e-10 |
|
Fucose permease [Carbohydrate transport and metabolism];
Pssm-ID: 440501 [Multi-domain] Cd Length: 391 Bit Score: 61.02 E-value: 5.17e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502753160 7 NKLSTLRNYYILLLLGFASGLPLALTGGTLQAWMTIENLDIKTIGFFTLVGQA--YVFKFLWAPAMDRYspsflGRRRGw 84
Cdd:COG0738 2 SKKNYRRALIAIYLLFFLWGFATALWGPLIPALKDAFGLSDAQAGLLLFAFFLgyLLASLPAGRLIDRF-----GYKRG- 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502753160 85 MLVTQLLLIVSIATMAFlkpSEHLWWLAALAVSVAFFSASQDIIFDAYKTDLlsqEERGSGAAISVLG--YRIAMLVS-- 160
Cdd:COG0738 76 LLLGLLLMALGLLLFAL---APSYPLLLLALFLLGLGLGLLDVAANPYVAAL---GPETAASRLNLLHafFSLGALLGpl 149
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502753160 161 -GGLALWLTTYIGWQNMYLIMAGMMLIGVYATLTAKEPKINTAPPKTlhQAVLEPLSDFFSRNNAWLILLLIVLYKLADA 239
Cdd:COG0738 150 lGGLLILLGLSLSWHLPYLILAVLLLLLALLFLRSKLPEIEEEEEEA--AGSAASLKSLLKNPRLLLGGLAIFLYVGAEG 227
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502753160 240 FALSLSTTFLIRGVGFTAAEVGMINkTLGLAATIVGALYGGYLMHKWSLFRALMIFGILQTVSNLsywILAVTPKDIYVM 319
Cdd:COG0738 228 AIGDWLPLYLKDVLGLSEATAALGL-SLFWGGMTIGRFLGGFLLKRFGPVRLLRLSALLAAVGLL---LALLAPGPWLAL 303
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502753160 320 GGAVFLenicgGMGTAAFVALLMTLCNKSFSATQFALLSALAAIGrvYVG-----PVAGWFAESHGWPMFYLFSIFIGLP 394
Cdd:COG0738 304 IGLALV-----GLGLSLMFPTIFSLALDGLGKRTAAAVSAVLIMG--IVGgaigpPLIGFLADAFGLRAAFLVPLVCYLL 376
|
....*....
gi 502753160 395 GLWLLFICR 403
Cdd:COG0738 377 ILLLALALK 385
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
29-401 |
1.12e-09 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 59.88 E-value: 1.12e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502753160 29 LALTGGTLQAWMTIENLDIKTIGFFTLVGQAyVFKFLWAPAMDRYSpsflgrRRGWMLVTQLLLIVSIATMAFlkpSEHL 108
Cdd:COG2271 29 LSVAAPPLQADLGLSAAQLGLLASAFFLGYA-LGQIPAGLLADRFG------RRRVLAIGLLLWGLATLLFGF---ATSF 98
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502753160 109 WWLAALAVSVAFFSASQDIIFDAYKTDLLSQEERGSGAAISVLGYRIAMLVSGGLALWLTTYIGWQNMYLIMAGMMLIGV 188
Cdd:COG2271 99 WQLLLLRFLLGLGEAGFFPAALKLIAEWFPPKERGRALGIFNAGGPLGGALAPPLLGWLLAAFGWRAAFLILGLPGLLLA 178
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502753160 189 YATLtakepkintappktlhqavleplsdffsrnnaWLILLLIVLYKLADAFALSLSTTFLIRGVGFTAAEVGMINkTLG 268
Cdd:COG2271 179 LLRF--------------------------------WLLALAYFLVYFALYGFLTWLPTYLVEVRGLSLAQAGLLL-SLP 225
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502753160 269 LAATIVGALYGGYLMHKWSLFRALMIFGILqTVSNLSYWILAVTPkDIYVMGGAVFLENICGGMGTAAFVALLMTLCNKS 348
Cdd:COG2271 226 FLAGIVGSLLGGWLSDRLGRRRKLVLAIGL-LLAALALLLLALLP-SPALAIALLFLAGFGLGGAFGLLWALAAELFPKK 303
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|...
gi 502753160 349 FSATQFALLSALAAIGRVYVGPVAGWFAESHGWPMFYLFSIFIGLPGLWLLFI 401
Cdd:COG2271 304 ARGTASGLVNTFGFLGGALGPLLVGYLLDATGYQAAFLLLAALALLAALLALL 356
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
61-403 |
2.03e-09 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 59.13 E-value: 2.03e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502753160 61 VFKFLWAPAMDRYSpsflgrRRGWMLVTQLLLIVSIATMAFlkpSEHLWWLAALAVSVAFFSASQDIIFDAYKTDLLSQE 140
Cdd:cd17325 46 LFSPPAGRLSDRFG------RKRLLLLGLLLLAVSTLLFAF---ATSYWQLLLARFLQGLASAAVWPAAMALIADIAPPE 116
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502753160 141 ERGSGAAISVLGYRIAMLVSGGLALWLTTYIGWQNMYLIMAGMMLIG-VYATLTAKEPKINTAPPKTLHQAVLEPLSDFF 219
Cdd:cd17325 117 ERGRAMGIFSSAIGLGFLIGPLLGGLLADALGYRAPFLVCAALALLAlVLALLLLPEPRPPPNKRAVSAARLRSGLRLLL 196
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502753160 220 SRNNAWLILLLIVLYKLADAFALSLSTTFLIRGVGFTAAEVGMINkTLGLAATIVGALYGGYLMHKWSlFRALMIFGILQ 299
Cdd:cd17325 197 RDRRLLALFLAIFVLAFAFGALEPFLPLYAAELGGLSPAQIGLLF-GAQGLASALSQPPAGKLSDRIG-RKPLILIGLLL 274
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502753160 300 TVSNLSYWILAVTpkdIYVMGGAVFLENICGGMGTAAFVALLMTLCNKSFSATQFALLSALAAIGRVyVGP-VAGWFAES 378
Cdd:cd17325 275 SAVALLLLPLATS---FWLLLLLLALLGLGLGLVFPATLALLADIVPPEGRGTAMGLFNTAFSLGMV-LGPlLGGFLYDA 350
|
330 340
....*....|....*....|....*
gi 502753160 379 HGWPMFYLFSIFIGLPGLWLLFICR 403
Cdd:cd17325 351 FGFATPFLAAAALLLLAAVLFLLLR 375
|
|
| MFS_FBT |
cd17484 |
Folate-biopterin transporter of the Major Facilitator Superfamily of transporters; The ... |
80-366 |
4.60e-07 |
|
Folate-biopterin transporter of the Major Facilitator Superfamily of transporters; The Folate-biopterin transporter (FBT) family includes folate carriers related to those of trypanosomatids in higher plant plastids and cyanobacteria. FBT mediates folate monoglutamate transport involved in tetrahydrofolate biosynthesis. It also mediates transport of antifolates, such as methotrexate and aminopterin. The FBT family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341037 [Multi-domain] Cd Length: 399 Bit Score: 51.84 E-value: 4.60e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502753160 80 RRRGWMLVTQLLLIVSIATMAFLkpSEHLWWLAALAVSVAFFS-ASQDIIFDA---YKTDLLSQEERGSGAAISVLGYRI 155
Cdd:cd17484 65 RRKPYLILAGALGALSWLALALV--SNSSLALALLLLLLASLGvAFSDVVIDAlvvEASRGAPQSLAGDLQSLCWGSSAI 142
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502753160 156 AMLVSGGLALWLTTYIGWQNMYLIMAGMMLIGVYATLTAKEPKINTAPPKTLHQAVLEPLSDFFSRNNAWLILLLIVLYk 235
Cdd:cd17484 143 GGIVGSYFSGYLLELLGPRTVFAVTSFFPLLLLIVAFFVKEERVPPHRTKENFDEQLKALWETVKQPSIWLPALFIFLY- 221
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502753160 236 LADAFALSLSTTFLIRGVGFTAAEVGMINkTLGLAATIVGALYGGYLMHKWSLFRALMIFGILQTVSNLSYWILA----- 310
Cdd:cd17484 222 QATPSSGSAMFYFMTNELGFSPEFLGRLR-VIGSIASLLGVLLYNRFLKHVPFRKIFFWTTVLLVLLGLTDLILVtrwnl 300
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*...
gi 502753160 311 --VTPKDIYVMGGAVFLEnICGGMGTAAFVALLMTLCNKSFSATQFALLSALAAIGRV 366
Cdd:cd17484 301 klGIPDHAFVLGDDAVVT-VIGEILFMPILVLAARLCPPGIEGTVFALLMSISNLGSL 357
|
|
| MFS_NepI_like |
cd17324 |
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ... |
65-400 |
1.96e-06 |
|
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340882 [Multi-domain] Cd Length: 370 Bit Score: 49.86 E-value: 1.96e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502753160 65 LWAPAMDRYSpsflgrRRGWMLVTQLLLIVSIATMAFlkpSEHLWWLAALAVSVAFFSASQDIIFDAYKTDLLSQEERGS 144
Cdd:cd17324 53 LLGPLSDRIE------RRRLLLVLLLLFILGNLLAAL---APSFALLLLARALAGLAHGGFWAIAAAYAADLVPPEKRGR 123
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502753160 145 GAAISVLGYRIAMLVSGGLALWLTTYIGWQNMYLIMAGMMLIGVYATLTAKEPkinTAPPKTLHQAVLEPLSDFFSRNNA 224
Cdd:cd17324 124 AIGLVFSGLTLGLVLGRPLGGLLGQLLGWRAAFLAIAVLALLAALLLWRLLPS---LPPKKPGSLGLLSSLLLLLRNPRL 200
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502753160 225 WLILLLIVLYKLADAFALSLSTTFLIRGVGFTAAEVGMINKTLGLAAtIVGALYGGYLMhKWSLFRALMIFGILQTVsnl 304
Cdd:cd17324 201 RLAYLITFLLFGGFFALYTYLAPFLTDVPGFSSSAIIGLLLLFGVAG-VVGSPLAGRLA-DRGGRRALLIALLLLAA--- 275
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502753160 305 SYWILAVTPKDIYVMGGAVFLENICGGMGTAAFVALLMTLcNKSFSATQFALLSALAAIGRVYVGPVAGWFAESHGWPMF 384
Cdd:cd17324 276 ALLLLTLLGPSPLLLLVGLVLWGLGFFAAHSALQTRVLRL-APEARGLASSLYLAAYNLGGALGAALGGLVLDHGGWAGV 354
|
330
....*....|....*.
gi 502753160 385 YLFSIFIGLPGLWLLF 400
Cdd:cd17324 355 GWVGAALLLLALLLAL 370
|
|
| Acatn |
pfam13000 |
Acetyl-coenzyme A transporter 1; The mouse Acatn is a 61 kDa hydrophobic protein with six to ... |
15-91 |
1.17e-05 |
|
Acetyl-coenzyme A transporter 1; The mouse Acatn is a 61 kDa hydrophobic protein with six to 10 transmembrane domains. It appears to promote 9-O-acetylation in gangliosides.
Pssm-ID: 372424 [Multi-domain] Cd Length: 543 Bit Score: 47.74 E-value: 1.17e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502753160 15 YYILLLLGFASGLPLALTGGT----LQAwmTIENLDIKTIGFFTLVGQAYVFKFLWAPAMDR-YSPSfLGRRRGWMLVTQ 89
Cdd:pfam13000 1 FYLLVALYFLQGIPVGLAFGTipflLKS--MAKETSFTSLGIFSMATYPYSLKILWSPIVDSiYSKK-IGRRRSWIIPVQ 77
|
..
gi 502753160 90 LL 91
Cdd:pfam13000 78 LV 79
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
220-401 |
4.65e-05 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 45.35 E-value: 4.65e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502753160 220 SRNNAWLILLLIVLYKLADAFALSLSTTFLIRGVGFTAAEVGMINkTLGLAATIVGALYGGYLMHKWSLFRALMIFGILQ 299
Cdd:COG2814 7 RRWLALLALALGAFLSGLGIGIVLPALPLIAADLGASPAQAGLVV-TAYLLGAALGAPLAGRLADRFGRRRVLLLGLLLF 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502753160 300 TVSNLsywILAVTPkDIYVMGGAVFLENICGGMGTAAFVALLMTLCNKSFSATQFALLSALAAIGRVYVGPVAGWFAESH 379
Cdd:COG2814 86 ALGSL---LCALAP-SLWLLLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLADLF 161
|
170 180
....*....|....*....|..
gi 502753160 380 GWPMFYLFSIFIGLPGLWLLFI 401
Cdd:COG2814 162 GWRWVFLVNAVLALLALLLLLR 183
|
|
| BT1 |
pfam03092 |
BT1 family; Members of this family are transmembrane proteins. Several are Leishmania putative ... |
75-366 |
8.34e-05 |
|
BT1 family; Members of this family are transmembrane proteins. Several are Leishmania putative proteins that are thought to be pteridine transporters. One such protein Swiss:Q25272, previously termed (and is still annotated as) ORFG, was shown to encode a biopterin transport protein using null mutants, thus being subsequently renamed BT1. The significant similarity of ORFG/BT1 to Trypanosoma brucei ESAG10 (a putative transmembrane protein and another member of this family) was previously noted. This family also contains five putative Arabidopsis thaliana proteins of unknown function. In addition, it also contains two predicted prokaryotic proteins (from the cyanobacteria Synechocystis and Synechococcus).
Pssm-ID: 308617 Cd Length: 432 Bit Score: 45.03 E-value: 8.34e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502753160 75 PSFLGRRRGWMLVTQLLLIVSIATMAFLKPSEHLWWLAALAVSVAFFSAS-QDIIFDAYKTDLLSQEERGSGA------A 147
Cdd:pfam03092 52 ALFGYRRRWYLALSGLLGGAFWLLYGLLPASEASAPVAAAFIFLSSLGVAiVDVLVDALVSERARQSPTPGPSlqswiwG 131
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502753160 148 ISVLGYRIAMLVSGGLALWLTTYIGwqnmYLIMAGMMLIGVYATLTAKEP------KINTAPPKTLHQAVLEPLSDFFSR 221
Cdd:pfam03092 132 CSAVGGIIGSVLSGPLLDTFKPQIS----FFVTAALQLLTCVVALLIKESslglpaKHEPKRPVPCLFGLFEMNREVISR 207
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502753160 222 N-------NAWLILLLIVLY------KLADAFALSLSTTFLirGVGFTAAEVGMInKTLGLAATIVGALYGGYLMHKWSL 288
Cdd:pfam03092 208 NwkafrysEILTPTLFAMLSqailplVIAKANVFFYTTNVL--GPNFSYSFYGTV-KVIGSIAGLIGVTLYNRFLKKHPY 284
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502753160 289 FRALMIFGILQTVSNLSYWILAV-------TPKDIYVMGGAVFLEnICGGMGTAAFVALLMTLCNKSFSATQFALLSALA 361
Cdd:pfam03092 285 RLTFGVTTVLQVLSGLFDLILVKrwnryigISDHMYILGDSIILE-VLYMLKFMPVLVLLARLCPRGSESTVFALLASIA 363
|
....*
gi 502753160 362 AIGRV 366
Cdd:pfam03092 364 NLGQS 368
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
78-195 |
2.18e-04 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 43.32 E-value: 2.18e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502753160 78 LGRRRGWMLVtqLLLIVSIATMAFLKPSEHLWWLAALAVSVAFFSASQDIIFDAYKTDLLSQEERGSGAAISVLGYRIAM 157
Cdd:COG2271 243 LGRRRKLVLA--IGLLLAALALLLLALLPSPALAIALLFLAGFGLGGAFGLLWALAAELFPKKARGTASGLVNTFGFLGG 320
|
90 100 110
....*....|....*....|....*....|....*...
gi 502753160 158 LVSGGLALWLTTYIGWQNMYLIMAGMMLIGVYATLTAK 195
Cdd:COG2271 321 ALGPLLVGYLLDATGYQAAFLLLAALALLAALLALLLL 358
|
|
| MFS_2 |
pfam13347 |
MFS/sugar transport protein; This family is part of the major facilitator superfamily of ... |
79-343 |
4.61e-04 |
|
MFS/sugar transport protein; This family is part of the major facilitator superfamily of membrane transport proteins.
Pssm-ID: 433134 [Multi-domain] Cd Length: 427 Bit Score: 42.68 E-value: 4.61e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502753160 79 GRRRGWMLVTQLLLIVSIATMA---FLKPSEHLWWLAALAVSVAFFSASQDIIFDAYKTDLLS-QEERGSGAAI------ 148
Cdd:pfam13347 65 GRRRPWLLLSAIILAVSFILLFtppELGRAPLFIWLLATYILLRIAYTFFEIPYWSLGPELTRdYDERTSLTSYrsffsv 144
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502753160 149 --SVLGYRIAMLVSGGLALWLTTYIGWQNMYLIMAGMMLIGVYATLTAKEPKINTAPPKTLHQAVLEPLSDFFS---RNN 223
Cdd:pfam13347 145 ggGLLAAALAFPLVLILGGTGLERKGYRIFALIGAVLMLLGVIITAAGTKERVSMRSKEDTGQKEAGSLLDMLKevfRNR 224
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502753160 224 AWLILLLIVLYKLADAFALSLSTTFLIRGVGFTAAEVGMINkTLGLAATIVGALYGGYLMHKWSLFRALMIFGILQTVsn 303
Cdd:pfam13347 225 AFLILLASFLLAALAMGVLNGLLLYYFRYVLGNGFAASAFP-LVFTIGALLGIPLWPPLAKRIGKKNTYILGALITIA-- 301
|
250 260 270 280
....*....|....*....|....*....|....*....|
gi 502753160 304 LSYWILAVTPKDIYVMGGAVFLENICGGMGTAAFVALLMT 343
Cdd:pfam13347 302 GFALALLLGPNNTLLFLVLYIIIGFGYGSSFFLPWSMLAD 341
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
227-489 |
4.98e-04 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 42.41 E-value: 4.98e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502753160 227 ILLLIVLYKLADAFALSLSTTFLIRGVGFTAAEVGMINkTLGLAATIVGALYGGYLMHKWSLFRALMIFGILQTVSNLsy 306
Cdd:pfam07690 1 LFLAAFLAALGRSLLGPALPLLLAEDLGISPTEIGLLL-TLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLL-- 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502753160 307 wiLAVTPKDIYVMGGAVFLENICGGMGTAAFVALLMTLCNKSFSATQFALLSALAAIGRVYVGPVAGWFAESHGWPMFYL 386
Cdd:pfam07690 78 --LLLFASSLWLLLVLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLFGWRAAFL 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502753160 387 FSIFIGLPGLWLLFICRNTLTYTEKNDNFISRTLFKSYYRIAFIIMLLAASIFIIWLICSCLIIIISSITHFIVLDGLQK 466
Cdd:pfam07690 156 ILAILSLLAAVLLLLPRPPPESKRPKPAEEARLSLIVAWKALLRDPVLWLLLALLLFGFAFFGLLTYLPLYQEVLGLSAL 235
|
250 260
....*....|....*....|...
gi 502753160 467 AISPVFSFSIAMGTVGLLLGGAL 489
Cdd:pfam07690 236 LAGLLLGLGGLLGAIGRLLLGRL 258
|
|
| MFS_MJ1317_like |
cd17370 |
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed ... |
92-188 |
1.57e-03 |
|
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed of Methanocaldococcus jannaschii MFS-type transporter MJ1317, Mycobacterium bovis protein Mb2288, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340928 [Multi-domain] Cd Length: 371 Bit Score: 40.60 E-value: 1.57e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502753160 92 LIVSIATMAFLKPSEHLWWLAALAVSVAFFSASQDIIFDAYKTDLLSQEERGSGAAISVLGYRIAMLVSGGLALWLTTYI 171
Cdd:cd17370 271 YLSLALAYLGFALGSSLWLLLLGFILWGLYMGAQESIERAAVADLVPAELRGTAYGLFNTVVGIGWLLASLIAGYLWDLI 350
|
90
....*....|....*..
gi 502753160 172 GWQNMYLIMAGMMLIGV 188
Cdd:cd17370 351 SPSAAFLFSAVLALIAL 367
|
|
| MFS_MdfA_MDR_like |
cd17320 |
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major ... |
64-402 |
1.89e-03 |
|
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as MdfA (also called chloramphenicol resistance pump Cmr), EmrD, MdtM, MdtL, bicyclomycin resistance protein (also called sulfonamide resistance protein), and the uncharacterized inner membrane transport protein YdhC. EmrD is a proton-dependent secondary transporter, first identified as an efflux pump for uncouplers of oxidative phosphorylation. It expels a range of drug molecules and amphipathic compounds across the inner membrane of E. coli. Similarly, MdfA is a secondary multidrug transporter that exports a broad spectrum of structurally and electrically dissimilar toxic compounds. These MDR transporters are drug/H+ antiporters (DHA) belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340878 [Multi-domain] Cd Length: 379 Bit Score: 40.64 E-value: 1.89e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502753160 64 FLWAPAMDRYSpsflgrRRGWMLVTQLLLIVSIATMAFlkpSEHLWWLAALAVSVAFFSASQDIIFDAYKTDLLSQEERG 143
Cdd:cd17320 52 LLYGPLSDRFG------RRPVLLAGLLLFILASLLCAL---ASSIEQLLIARFLQGLGAAAGSVVARAIVRDLYSGAELA 122
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502753160 144 SGAAISVLGYRIAMLVSGGLALWLTTYIGWQNMYLIMAGMMLIGVYATLTAKEPKINTAPPKTLHQAVLEPLSDFFSRNN 223
Cdd:cd17320 123 KIFSLLMMILAIAPALAPLLGGLLLLFFGWRAIFVFLALLGLLLLLLVLLFLPETLPEEKRKPLLSSLLRAYKRVLKNRR 202
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502753160 224 AWLILLLIVLYKLADAFALSLSTTFLIRGVGFTAAEVGMINKTLGLAAtIVGALYGGYLMHKWSLFRALMIFGILQTVSN 303
Cdd:cd17320 203 FLGYALALGLSFAGLFAYLAAAPFIYIEQLGLSPAQFGLLFALNAIAL-ILGSLLNGRLVRRFGPRRLLRLGLLLLLAAA 281
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502753160 304 LSYWILAVT-PKDIYVMGGAVFLENICGGMGTAAFVALLMTLCNKSFSATQfALLSALAAIGRVYVGPVAGWFAESHGWP 382
Cdd:cd17320 282 LVLLLAALLgGLSLWPLVAPLFLIFFGFGLIFPNATSLALEPFPHVAGTAS-ALLGFLQFLIGALAGALVGLLPNGTALP 360
|
330 340
....*....|....*....|
gi 502753160 383 MfYLFSIFIGLPGLWLLFIC 402
Cdd:cd17320 361 M-GLLILVLGLLALLLLILL 379
|
|
| MFS_YcaD_like |
cd17477 |
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of ... |
227-410 |
2.10e-03 |
|
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MFS-type transporter YcaD, Bacillus subtilis MFS-type transporter YfkF, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341030 [Multi-domain] Cd Length: 360 Bit Score: 40.23 E-value: 2.10e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502753160 227 ILLLIVLYKLADAFALSLSTTFLIRGvGFTAAEVGmINKTLGLAATIVGALYGGYLMHKWSLFRALMIFGILQTVSNLsy 306
Cdd:cd17477 1 LLLSVALLGLGSGLLLPLLSLRLERE-GVSTALIG-LVASAYYLGILLGSPLVPRLIRRVGHIRAFAAGAAITAVSVL-- 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502753160 307 wILAVTPkDIYVMGGAVFLENICGGMGTAAFVALLMTLCNKSFSATQFALLSALAAIGRVyVGPVAGWFAESHGWPMFYL 386
Cdd:cd17477 77 -LLALTD-SPWVWFLLRFVMGIGLAGLFVVSESWLNALATNENRGRVLGLYSTVLGLGFA-LGPLLLALVGTAGALPFLI 153
|
170 180
....*....|....*....|....
gi 502753160 387 FSIFIGLPGLWLLFICRNTLTYTE 410
Cdd:cd17477 154 AAVLLLLALVPLLLTRRAAPEIEE 177
|
|
| MFS_YfcJ_like |
cd17489 |
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ... |
78-396 |
2.50e-03 |
|
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341042 [Multi-domain] Cd Length: 367 Bit Score: 40.27 E-value: 2.50e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502753160 78 LGRRRGWMLVTQLLLIVSIATMAFLKPSEHLWWLAAL----AVSVAFFSASQDiifdAYKTDLLSQEERGSGAAISVLGY 153
Cdd:cd17489 54 LLDRFGRKRLLLIGLLIFALATLLYLLATSVALLLVLrlihGIGWGAFTTAAA----TLVADIIPPSRRGEGIGYYGLAT 129
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502753160 154 RIAMLVSGGLALWLTTYIGWQNMYLIMAGMMLIGVYATLTAKEPKintAPPKTLHQAVLEPLSDFFSRnNAWLILLLIVL 233
Cdd:cd17489 130 TLAMALGPALGLFLYQHLGFAVLFIVAAVLALLALLLVFLVKDPP---PVAAEEAEAGTRAFRRLVEK-KVLPPALILFL 205
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502753160 234 YkladAFALSLSTTFLirgvGFTAAEVGMINKTLGL----AATIVGALYGGYLMHKWSLFRALMIFGILQTvsnLSYWIL 309
Cdd:cd17489 206 A----SIAYGAISTFL----PLYAAERGISNAGLFFtvyaIALLLSRPFSGKLSDRKGPKTVIIPGLLLLA---LGLLLL 274
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502753160 310 AVTPKDIYVMGGAVFLeNICGGMGTAAFVALLMTLCNKSFSATQFALLSALAAIGRVYVGPVAGWFAESHGWPMFYLFSI 389
Cdd:cd17489 275 SFAGSPWMLLLAAVLY-GLGFGLLFPALQALAVDLVPPHRRGAANGTFFIFFDLGIGLGGLLLGLVAELFGYRAMFLLAA 353
|
....*..
gi 502753160 390 FIGLPGL 396
Cdd:cd17489 354 VVVLLAL 360
|
|
| MFS_MFSD6 |
cd17335 |
Major facilitator superfamily domain-containing protein 6; Human Major facilitator superfamily ... |
15-294 |
2.74e-03 |
|
Major facilitator superfamily domain-containing protein 6; Human Major facilitator superfamily domain-containing protein 6 (MFSD6) is also called macrophage MHC class I receptor 2 homolog (MMR2). It has been postulated as a possible receptor for human leukocyte antigen (HLA)-B62. MFSD6 is conserved through evolution and appeared before bilateral animals. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340893 [Multi-domain] Cd Length: 375 Bit Score: 39.87 E-value: 2.74e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502753160 15 YYILLLLGFASGLPLaltggtLQAWMTIENLDIKTIGFftLVGQAYVFKF----LWAPAMDRYspsflGRRRGWMLVTql 90
Cdd:cd17335 5 FYFFFFAALGSLLPF------LSVYLKQLGLSPTQIGI--LIGIRPFVRFlsapLWGALADRF-----GKRKALLLLS-- 69
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502753160 91 LLIVSIATMAFLKPSEHLWWLAALAVSVAFFSASQDIIFDAYKTDLLSQEE------RGSGAaisvLGYRIAMLVSGGLA 164
Cdd:cd17335 70 LLAAVLFFLSLFFVAQIFWLLLLLVILGAFFSAPVVPLVDSITLQYLGEERerygkqRLWGS----IGFGIAALLVGILI 145
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502753160 165 LWLTTYIGWQNMYLIMAGMMLIGVYATLtakepKINTAPPKTLHQAVLEPLSDFFSRNNAWLILLLIVLYKLADAFALSL 244
Cdd:cd17335 146 DRSSTYKNYTIAFYVFAVLMLLALLLAL-----KFPFRPKHPEPNENTGGLLALLRNPRVLAFLLVAFLMGFGHGLIYSF 220
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|
gi 502753160 245 STTFLiRGVGFTAAEVGMInKTLGLAATIVGALYGGYLMHKWSLFRALMI 294
Cdd:cd17335 221 LFWHL-QDLGGSKTLIGLL-WTVGVVSEIPFFFFSSRLIQRFGHVGLLYL 268
|
|
| MFS_YfmO_like |
cd17474 |
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ... |
76-402 |
3.37e-03 |
|
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341027 [Multi-domain] Cd Length: 374 Bit Score: 39.86 E-value: 3.37e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502753160 76 SFLGRRRgwMLVTQLLLIVSIATMAFLKPSehLWWLAALAV-----SVAFFSASQDIIFDAYKTDLLSQEERGSGAAISv 150
Cdd:cd17474 59 DRFGRKK--VLLPGLLLFGIGGLLCGLSDS--FALLLAGRAlqgigAAGLGPLALTLIGDLFEGGERAKAMGLYEAALG- 133
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502753160 151 LGYRIAMLVSGGLALWlttyiGWQNMYLIMAGMMLIGVYATLTAKEPKINTA--PPKTLHQAVLEPLSDFFSRNNAWLIL 228
Cdd:cd17474 134 LGIAVGPLLGGLLAAI-----SWRYPFFLLAALIPVAFLAILFLLPEPKEKAksSSATKLRDLKKALRGRGLLTFLVSAF 208
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502753160 229 LLIVLYkladaFA-LSLSTTFLIRGVGFTAAEVGMINKTLGLAaTIVGALYGGYLMHKWSLFRALMIFGILQTVsnLSYW 307
Cdd:cd17474 209 LYFFLY-----FAfLTYLPFLLELLYGISPIIIGLLFAGWSVL-LALGSLFVGRLLKKRFGARRILVIGLLLYA--LSLL 280
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502753160 308 ILAVTPkDIYVMGGAVFLENICGGMGTAAFVALLMTLCNKSFSATQFALLSALAAIGRVYVGPVAGWFAESHGWPMFYLF 387
Cdd:cd17474 281 LLGFVP-SLALLLIAIVLFGLGLGLNLPLLTTLVTELAPEEERGTASSLYNFVRFLGQAVGPLLFGLLLEIFGLSAPFLV 359
|
330
....*....|....*
gi 502753160 388 SIFIGLPGLWLLFIC 402
Cdd:cd17474 360 GAAIALAAAVLLALL 374
|
|
| MFS_ExuT_GudP_like |
cd17319 |
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ... |
134-401 |
4.58e-03 |
|
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340877 [Multi-domain] Cd Length: 358 Bit Score: 39.09 E-value: 4.58e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502753160 134 TDLLSQEERGSGAAISVLGYRIAMLVSGGLALWLTTYIGWQNMYLIMAGMMLIGVYATLtakepkintappktlhqavle 213
Cdd:cd17319 117 AEWFPARERGRATGLFNSGAPLGAAIGPPLSGWLLLLFGWRWAFIIEGLLGLLLAVLWW--------------------- 175
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502753160 214 plsdFFSRnNAWLILLLIVLYKLADAFALSLSTTFLIRGVGFTAAEVGMINkTLGLAATIVGALYGGYLMHKWSLFRALM 293
Cdd:cd17319 176 ----FYLR-QVWGLALGYFGINYALYGLLTWLPTYLKQARGFSLKQVGLLA-AIPFLAGAIGMILGGRLSDRLLRGARRL 249
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502753160 294 IFGILQTVSNLSyWILAVTPKDIYVMGGAVFLENICGGMGTAAFVALLMTLCNKSFSATQFALLSALAAIGRVYVGPVAG 373
Cdd:cd17319 250 VIIIGLLLAAVG-LLLAYLTTSPVVAVILLSLAGFGIGAASPVFWSLPADLLPGEAAATAGGLINSGGNLGGFVAPLLIG 328
|
250 260
....*....|....*....|....*....
gi 502753160 374 W-FAESHGWPMFYLFSIFIGLPGLWLLFI 401
Cdd:cd17319 329 YlVDATGSYTAAFLFLAAVALLAALLVLL 357
|
|
| MFS_Set |
cd17471 |
Sugar efflux transporter (Set) family of the Major Facilitator Superfamily of transporters; ... |
81-400 |
4.59e-03 |
|
Sugar efflux transporter (Set) family of the Major Facilitator Superfamily of transporters; This family is composed of sugar transporters such as Escherichia coli Sugar efflux transporter SetA, SetB, SetC and other sugar transporters. SetA, SetB, and SetC are involved in the efflux of sugars such as lactose, glucose, IPTG, and substituted glucosides or galactosides. They may be involved in the detoxification of non-metabolizable sugar analogs. The Set family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341024 [Multi-domain] Cd Length: 371 Bit Score: 39.45 E-value: 4.59e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502753160 81 RRGWMLVTQLLLIVSIATMAFLKpseHLWWLAALAVSV-AFFSASQDIIFdAYKTDLLSQE-ERGSGAAISVL--GYRIA 156
Cdd:cd17471 62 RKPLILLALLAGALGYLLFAFLR---NYWVLLLVGVVLlSLGAAAFPQLF-ALAREYADRSsGRDATLFNSVLraAFSLA 137
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502753160 157 MLVSGGLALWLTTYIGWQNMYLIMAGMMLI-GVYATLTAKEPKINTAPPKTLHQAVLEPLsdffsRNNAWLILLLIVLYK 235
Cdd:cd17471 138 WVIGPPLAFLLLDVLGFTGLFLLAALLYLVvALLVLFLLPSVKPPAQKATPASSLVKAPV-----NRRLLLLFAAFTLLF 212
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502753160 236 LADAFALSLSTTFLIRGVGFTAAEVGMInktLGLAAT--IVGALYGGYLMHKWSLfRALMIFGILQTVsnLSYWILAVTP 313
Cdd:cd17471 213 AANSMYIIAMPLYVTNELGGSESWVGLL---FGLAAAleIPIMLLAGLLAKRFGK-RRLLLAGFLAGV--LFYLGLALAT 286
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502753160 314 KDIYVMGGAVFLenicgGMGTAAFVALLMTLC-----NKSFSATqfALLSALAAIGRVYVGPVAGWFAESHGWPMFYLFS 388
Cdd:cd17471 287 SLWQLIALQLLN-----AIFIGITAGLGISYFqdlmpGQPGLAT--TLYSNASRIGSLLGGLLAGVIAQYFGYRAVFLVC 359
|
330
....*....|..
gi 502753160 389 IFIGLPGLWLLF 400
Cdd:cd17471 360 AVLALLALVLLL 371
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
224-402 |
7.85e-03 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 38.70 E-value: 7.85e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502753160 224 AWLILLLIVLYKLADAFALSLSTTFLIRGVGFTAAEVGMINkTLGLAATIVGALYGGYLMHKWSLFRALMIFGILQTVSN 303
Cdd:COG2271 11 ILALLFLAYFLNYLDRSNLSVAAPPLQADLGLSAAQLGLLA-SAFFLGYALGQIPAGLLADRFGRRRVLAIGLLLWGLAT 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502753160 304 LsywILAVTPkDIYVMGGAVFLENICGGMGTAAFVALLMTLCNKSFSATQFALLSALAAIGRVYVGPVAGWFAESHGWPM 383
Cdd:COG2271 90 L---LFGFAT-SFWQLLLLRFLLGLGEAGFFPAALKLIAEWFPPKERGRALGIFNAGGPLGGALAPPLLGWLLAAFGWRA 165
|
170 180
....*....|....*....|...
gi 502753160 384 FYLF----SIFIGLPGLWLLFIC 402
Cdd:COG2271 166 AFLIlglpGLLLALLRFWLLALA 188
|
|
| |
