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Conserved domains on  [gi|502819896|ref|WP_013054872|]
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MULTISPECIES: stage V sporulation protein T [Bacillaceae]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
SpoVT COG5845
Stage V sporulation protein SpoVT, regulator of stationary/sporulation gene expression [Cell ...
 1-178 1.06e-120

Stage V sporulation protein SpoVT, regulator of stationary/sporulation gene expression [Cell cycle control, cell division, chromosome partitioning, Transcription];


:

Pssm-ID: 444547  Cd Length: 180  Bit Score: 337.91  E-value: 1.06e-120
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502819896   1 MKATGIVRRIDDLGRVVIPKEIRRTLRIREGDPLEIFVDRDGEVILKKYSPISELGDFAKEYGEALYDSLGHPVLICDRD 80
Cdd:COG5845    1 MKATGIVRRIDDLGRVVIPKEIRRTLRIREGDPLEIFVDRDGEVILKKYSPIGELGDFAKEYAESLAESTGHIVLITDRD 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502819896  81 VFIAVAGSSKKEYLNKNISSLVESVMESRSSSLVTDGKNLEFVDGYEENISSYTIGPIIANGDPIGAVVIFSKDK--SLG 158
Cdd:COG5845   81 EIIAVAGASKKEYLNKPISSELEKIMEERKTVLENDGGELELVEDDEEKFTSQVIAPIIAEGDPIGAVILLSKEEgaKMG 160

                        170       180
                 ....*....|....*....|
gi 502819896 159 EVEHKAAETAASFLSRQMEQ 178
Cdd:COG5845  161 ELEVKLAETAAGFLAKQMEQ 180
 
Name Accession Description Interval E-value
SpoVT COG5845
Stage V sporulation protein SpoVT, regulator of stationary/sporulation gene expression [Cell ...
 1-178 1.06e-120

Stage V sporulation protein SpoVT, regulator of stationary/sporulation gene expression [Cell cycle control, cell division, chromosome partitioning, Transcription];


Pssm-ID: 444547  Cd Length: 180  Bit Score: 337.91  E-value: 1.06e-120
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502819896   1 MKATGIVRRIDDLGRVVIPKEIRRTLRIREGDPLEIFVDRDGEVILKKYSPISELGDFAKEYGEALYDSLGHPVLICDRD 80
Cdd:COG5845    1 MKATGIVRRIDDLGRVVIPKEIRRTLRIREGDPLEIFVDRDGEVILKKYSPIGELGDFAKEYAESLAESTGHIVLITDRD 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502819896  81 VFIAVAGSSKKEYLNKNISSLVESVMESRSSSLVTDGKNLEFVDGYEENISSYTIGPIIANGDPIGAVVIFSKDK--SLG 158
Cdd:COG5845   81 EIIAVAGASKKEYLNKPISSELEKIMEERKTVLENDGGELELVEDDEEKFTSQVIAPIIAEGDPIGAVILLSKEEgaKMG 160

                        170       180
                 ....*....|....*....|
gi 502819896 159 EVEHKAAETAASFLSRQMEQ 178
Cdd:COG5845  161 ELEVKLAETAAGFLAKQMEQ 180
spore_V_T TIGR02851
stage V sporulation protein T; Members of this protein family are the stage V sporulation ...
 2-177 4.28e-99

stage V sporulation protein T; Members of this protein family are the stage V sporulation protein T (SpoVT), a protein of the sporulation/germination program in Bacillus subtilis and related species. The amino-terminal 50 amino acids are nearly perfectly conserved across all endospore-forming bacteria. SpoVT is a DNA-binding transcriptional regulator related to AbrB (See pfam04014). [Regulatory functions, DNA interactions, Cellular processes, Sporulation and germination]


Pssm-ID: 131898 [Multi-domain]  Cd Length: 180  Bit Score: 283.58  E-value: 4.28e-99
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502819896    2 KATGIVRRIDDLGRVVIPKEIRRTLRIREGDPLEIFVDRDGEVILKKYSPISELGDFAKEYGEALYDSLGHPVLICDRDV 81
Cdd:TIGR02851   1 KATGIVRRIDDLGRVVIPKEIRRTLRIREGDPLEIFTDREGEVILKKYSPIGELGDFAKEYAESLYQSLGHIVLITDRDT 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502819896   82 FIAVAGSSKKEYLNKNISSLVESVMESRSSSLVTDGKN--LEFVDGYEENISSYTIGPIIANGDPIGAVVIFSKD--KSL 157
Cdd:TIGR02851  81 VIAVAGVSKKEYLNKPISDELEDTMEERKTVILSDTKDgpIEIIDGQEFEYTSQVIAPIIAEGDPIGAVIIFSKEpgEKL 160

                         170       180
                  ....*....|....*....|
gi 502819896  158 GEVEHKAAETAASFLSRQME 177
Cdd:TIGR02851 161 GEVEQKAAETAAAFLGKQME 180
SpoVT_C pfam15714
Stage V sporulation protein T C-terminal, transcription factor; SpoVT_C is the C-terminal part ...
 54-177 3.15e-61

Stage V sporulation protein T C-terminal, transcription factor; SpoVT_C is the C-terminal part of the stage V sporulation protein T, a transcription factor involved in endospore formation in Gram-positive bacteria such as Bacillus subtilis. Sporulation is induced by conditions of environmental stress to protect the genome. SpoVT behaves as a tetramer that shows an overall significant distortion mediated by electrostatic interactions. Two monomers dimerize via the highly charged N-terminal AbrB-like domains, family pfam04014, to form swapped-hairpin beta-barrels. These asymmetric dimers then form tetramers through the formation of mixed helix bundles between their C-terminal domains. The C-termini themselves fold as GAF (cGMP-specific and cGMP-stimulated phosphodiesterases, Anabaena adenylate cyclases, and Escherichia coli FhlA) domains.


Pssm-ID: 464818  Cd Length: 128  Bit Score: 185.76  E-value: 3.15e-61
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502819896   54 ELGDFAKEYGEALYDSLGHPVLICDRDVFIAVAGSSKKEYLNKNISSLVESVMESRSSSLVTDGKNLE--FVDGYEENIS 131
Cdd:pfam15714   1 ELSEFAKEYAESLAQTTGHIVCITDRDQVIAVAGGGKKEYLGKPISKELEEIMEDRKTVLAKEGDKLFvpITEDGEEEYT 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 502819896  132 SYTIGPIIANGDPIGAVVIFSKDKS--LGEVEHKAAETAASFLSRQME 177
Cdd:pfam15714  81 AQVIAPIIAEGDVIGAVILLSKEEKkkMGETEKKLAETAAGFLGKQME 128
SpoVT_AbrB smart00966
SpoVT / AbrB like domain; This domain is found in AbrB from Bacillus subtilis. The product of ...
 8-48 6.61e-10

SpoVT / AbrB like domain; This domain is found in AbrB from Bacillus subtilis. The product of the abrB gene is an ambiactive repressor and activator of the transcription of genes expressed during the transition state between vegetative growth and the onset of stationary phase and sporulation. AbrB is thought to interact directly with the transcription initiation regions of genes under its control. AbrB contains a helix-turn-helix structure, but this domain ends before the helix-turn-helix begins. The product of the B. subtilis gene spoVT is another member of this family and is also a transcriptional regulator. DNA-binding activity in this AbrB homologue requires hexamerisation. Another family member has been isolated from the Sulfolobus solfataricus and has been identified as a homologue of bacterial repressor-like proteins. The Escherichia coli family member SohA or Prl1F appears to be bifunctional and is able to regulate its own expression as well as relieve the export block imposed by high-level synthesis of beta-galactosidase hybrid proteins.


Pssm-ID: 198034 [Multi-domain]  Cd Length: 45  Bit Score: 52.12  E-value: 6.61e-10
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 502819896     8 RRIDDLGRVVIPKEIRRTLRIREGDPLEIFVDRDGEVILKK 48
Cdd:smart00966   1 VKVGNSGQVTIPKEVREKLGIKEGDEVELEVDGDGIILEPV 41
 
Name Accession Description Interval E-value
SpoVT COG5845
Stage V sporulation protein SpoVT, regulator of stationary/sporulation gene expression [Cell ...
 1-178 1.06e-120

Stage V sporulation protein SpoVT, regulator of stationary/sporulation gene expression [Cell cycle control, cell division, chromosome partitioning, Transcription];


Pssm-ID: 444547  Cd Length: 180  Bit Score: 337.91  E-value: 1.06e-120
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502819896   1 MKATGIVRRIDDLGRVVIPKEIRRTLRIREGDPLEIFVDRDGEVILKKYSPISELGDFAKEYGEALYDSLGHPVLICDRD 80
Cdd:COG5845    1 MKATGIVRRIDDLGRVVIPKEIRRTLRIREGDPLEIFVDRDGEVILKKYSPIGELGDFAKEYAESLAESTGHIVLITDRD 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502819896  81 VFIAVAGSSKKEYLNKNISSLVESVMESRSSSLVTDGKNLEFVDGYEENISSYTIGPIIANGDPIGAVVIFSKDK--SLG 158
Cdd:COG5845   81 EIIAVAGASKKEYLNKPISSELEKIMEERKTVLENDGGELELVEDDEEKFTSQVIAPIIAEGDPIGAVILLSKEEgaKMG 160

                        170       180
                 ....*....|....*....|
gi 502819896 159 EVEHKAAETAASFLSRQMEQ 178
Cdd:COG5845  161 ELEVKLAETAAGFLAKQMEQ 180
spore_V_T TIGR02851
stage V sporulation protein T; Members of this protein family are the stage V sporulation ...
 2-177 4.28e-99

stage V sporulation protein T; Members of this protein family are the stage V sporulation protein T (SpoVT), a protein of the sporulation/germination program in Bacillus subtilis and related species. The amino-terminal 50 amino acids are nearly perfectly conserved across all endospore-forming bacteria. SpoVT is a DNA-binding transcriptional regulator related to AbrB (See pfam04014). [Regulatory functions, DNA interactions, Cellular processes, Sporulation and germination]


Pssm-ID: 131898 [Multi-domain]  Cd Length: 180  Bit Score: 283.58  E-value: 4.28e-99
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502819896    2 KATGIVRRIDDLGRVVIPKEIRRTLRIREGDPLEIFVDRDGEVILKKYSPISELGDFAKEYGEALYDSLGHPVLICDRDV 81
Cdd:TIGR02851   1 KATGIVRRIDDLGRVVIPKEIRRTLRIREGDPLEIFTDREGEVILKKYSPIGELGDFAKEYAESLYQSLGHIVLITDRDT 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502819896   82 FIAVAGSSKKEYLNKNISSLVESVMESRSSSLVTDGKN--LEFVDGYEENISSYTIGPIIANGDPIGAVVIFSKD--KSL 157
Cdd:TIGR02851  81 VIAVAGVSKKEYLNKPISDELEDTMEERKTVILSDTKDgpIEIIDGQEFEYTSQVIAPIIAEGDPIGAVIIFSKEpgEKL 160

                         170       180
                  ....*....|....*....|
gi 502819896  158 GEVEHKAAETAASFLSRQME 177
Cdd:TIGR02851 161 GEVEQKAAETAAAFLGKQME 180
SpoVT_C pfam15714
Stage V sporulation protein T C-terminal, transcription factor; SpoVT_C is the C-terminal part ...
 54-177 3.15e-61

Stage V sporulation protein T C-terminal, transcription factor; SpoVT_C is the C-terminal part of the stage V sporulation protein T, a transcription factor involved in endospore formation in Gram-positive bacteria such as Bacillus subtilis. Sporulation is induced by conditions of environmental stress to protect the genome. SpoVT behaves as a tetramer that shows an overall significant distortion mediated by electrostatic interactions. Two monomers dimerize via the highly charged N-terminal AbrB-like domains, family pfam04014, to form swapped-hairpin beta-barrels. These asymmetric dimers then form tetramers through the formation of mixed helix bundles between their C-terminal domains. The C-termini themselves fold as GAF (cGMP-specific and cGMP-stimulated phosphodiesterases, Anabaena adenylate cyclases, and Escherichia coli FhlA) domains.


Pssm-ID: 464818  Cd Length: 128  Bit Score: 185.76  E-value: 3.15e-61
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502819896   54 ELGDFAKEYGEALYDSLGHPVLICDRDVFIAVAGSSKKEYLNKNISSLVESVMESRSSSLVTDGKNLE--FVDGYEENIS 131
Cdd:pfam15714   1 ELSEFAKEYAESLAQTTGHIVCITDRDQVIAVAGGGKKEYLGKPISKELEEIMEDRKTVLAKEGDKLFvpITEDGEEEYT 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 502819896  132 SYTIGPIIANGDPIGAVVIFSKDKS--LGEVEHKAAETAASFLSRQME 177
Cdd:pfam15714  81 AQVIAPIIAEGDVIGAVILLSKEEKkkMGETEKKLAETAAGFLGKQME 128
AbrB COG2002
Bifunctional DNA-binding transcriptional regulator of stationary/sporulation/toxin gene ...
 7-61 7.21e-14

Bifunctional DNA-binding transcriptional regulator of stationary/sporulation/toxin gene expression and antitoxin component of the YhaV-PrlF toxin-antitoxin module [Transcription, Defense mechanisms];


Pssm-ID: 441605 [Multi-domain]  Cd Length: 70  Bit Score: 63.07  E-value: 7.21e-14
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 502819896   7 VRRIDDLGRVVIPKEIRRTLRIREGDPLEIFVDRDGEVILKKYSPISELGDFAKE 61
Cdd:COG2002    3 TVKVTSKGQITIPKEIREALGIKEGDKLEVIVDGDGIVLKPVKPPVEELRGLLKG 57
lp_hng_hel_AbrB TIGR01439
looped-hinge helix DNA binding domain, AbrB family; This DNA-binding domain family includes ...
 8-50 2.22e-11

looped-hinge helix DNA binding domain, AbrB family; This DNA-binding domain family includes AbrB, a transition state regulator in Bacillus subtilis, whose DNA-binding domain structure in solution was determined by NMR. The domain binds DNA as a dimer in what is termed a looped-hinge helix fold. Some members of the family have two copies of the domain in tandem. The domain is found usually at the N-terminus of a small protein. This model excludes members of family TIGR02609. [Regulatory functions, DNA interactions]


Pssm-ID: 273625 [Multi-domain]  Cd Length: 43  Bit Score: 56.11  E-value: 2.22e-11
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 502819896    8 RRIDDLGRVVIPKEIRRTLRIREGDPLEIFVDRDGEVILKKYS 50
Cdd:TIGR01439   1 VTVDKKGQIVIPKEIREKLGLKEGDRLEVIRVEDGEIILRPKR 43
SpoVT_AbrB smart00966
SpoVT / AbrB like domain; This domain is found in AbrB from Bacillus subtilis. The product of ...
 8-48 6.61e-10

SpoVT / AbrB like domain; This domain is found in AbrB from Bacillus subtilis. The product of the abrB gene is an ambiactive repressor and activator of the transcription of genes expressed during the transition state between vegetative growth and the onset of stationary phase and sporulation. AbrB is thought to interact directly with the transcription initiation regions of genes under its control. AbrB contains a helix-turn-helix structure, but this domain ends before the helix-turn-helix begins. The product of the B. subtilis gene spoVT is another member of this family and is also a transcriptional regulator. DNA-binding activity in this AbrB homologue requires hexamerisation. Another family member has been isolated from the Sulfolobus solfataricus and has been identified as a homologue of bacterial repressor-like proteins. The Escherichia coli family member SohA or Prl1F appears to be bifunctional and is able to regulate its own expression as well as relieve the export block imposed by high-level synthesis of beta-galactosidase hybrid proteins.


Pssm-ID: 198034 [Multi-domain]  Cd Length: 45  Bit Score: 52.12  E-value: 6.61e-10
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 502819896     8 RRIDDLGRVVIPKEIRRTLRIREGDPLEIFVDRDGEVILKK 48
Cdd:smart00966   1 VKVGNSGQVTIPKEVREKLGIKEGDEVELEVDGDGIILEPV 41
MazE_antitoxin pfam04014
Antidote-toxin recognition MazE, bacterial antitoxin; AbrB-like is a family of small proteins ...
 8-48 4.40e-08

Antidote-toxin recognition MazE, bacterial antitoxin; AbrB-like is a family of small proteins that operate in conjunction with a cognate toxin molecule. The commonly attributed role of toxin-antitoxin systems is to maintain low-copy number plasmids from one generation to the next. Such gene-pairs are also found on chromosomes and to be associated with a number of biological functions such as: reduction of protein synthesis, gene regulation and retardation of cell growth under nutritional stress. This family includes proteins from a number of different pairings, eg MazE, AbrB, VapB, PhoU, PemI-like and SpoVT. MazE is the antidote to the toxin MazF of E. coli. MazE-MazF in E. coli is a regulated prokaryotic chromosomal addiction module. MazE antidote is degraded by the ClpPA protease of the bacterial proteasome. MazE-MazF is thought to play a role in programmed cell death when cells suffer nutrient deprivation, and MazE-MazF modules have also been implicated in the bacteriostatic effects of other addiction modules.


Pssm-ID: 397909 [Multi-domain]  Cd Length: 44  Bit Score: 47.12  E-value: 4.40e-08
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 502819896    8 RRIDDLGRVVIPKEIRRTLRIREGDPLEIFVDRDGEVILKK 48
Cdd:pfam04014   1 FKVGNSGAVRIPKEVRKALGIKEGDEVELEVDGDKIILKPK 41
MazE COG2336
Antitoxin component MazE of the MazEF toxin-antitoxin module [Defense mechanisms];
16-50 7.78e-04

Antitoxin component MazE of the MazEF toxin-antitoxin module [Defense mechanisms];


Pssm-ID: 441907  Cd Length: 80  Bit Score: 36.79  E-value: 7.78e-04
                         10        20        30
                 ....*....|....*....|....*....|....*
gi 502819896  16 VVIPKEIRRTLRIREGDPLEIFVDrDGEVILKKYS 50
Cdd:COG2336   14 VRIPKALLEQLGLKEGDEVELEVE-DGRIVIRPVR 47
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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