|
Name |
Accession |
Description |
Interval |
E-value |
| MFS_ExuT_GudP_like |
cd17319 |
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ... |
5-410 |
1.61e-89 |
|
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340877 [Multi-domain] Cd Length: 358 Bit Score: 275.60 E-value: 1.61e-89
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502820707 5 RWSIVFLIAVGVVVNYFDRINMSIAMPLLQKEFNLTAGQMGIFLSAFAWSYALLQLPIGPLLDKIGVKWVTRVATVIWTV 84
Cdd:cd17319 1 RWRIIPLLFLAYVINYLDRVNISVAAPTIMKDLGLSPTQYGLIASAFFLGYALFQVPGGWLLDRFGARKVLAVSMLLWSL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502820707 85 ACLLTAVANGWGLIILSRVLLGVGEAPFFPSAAKAVSHWVPRQERGKAIAAYDSQSKLSNAIGAPILALIVTEWGWRGGF 164
Cdd:cd17319 81 FTALTGFATSLTSLYVLRFLLGVAEAGFFPGAIKALAEWFPARERGRATGLFNSGAPLGAAIGPPLSGWLLLLFGWRWAF 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502820707 165 LATAILSFIYAIVYWIWYrephederltkeeydyivqggsqsseeakgsamenirylltkRKVWAVFIGFAAYGYSWFLF 244
Cdd:cd17319 161 IIEGLLGLLLAVLWWFYL------------------------------------------RQVWGLALGYFGINYALYGL 198
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502820707 245 LTWLPGYLATEMNMSILKSGWYSAIPWIVGTITEIViGGWLVDRLINKgynrtRVSKFFLVIGMVFGLSIIGAAFTHSAN 324
Cdd:cd17319 199 LTWLPTYLKQARGFSLKQVGLLAAIPFLAGAIGMIL-GGRLSDRLLRG-----ARRLVIIIGLLLAAVGLLLAYLTTSPV 272
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502820707 325 VAVFWISTALGGLVVTSAVAYSIPTFIAPKGTVGTLTGLLTFGNNSMAIVAPITTGFIVQATGSFMYAFLLAAAFLVIGI 404
Cdd:cd17319 273 VAVILLSLAGFGIGAASPVFWSLPADLLPGEAAATAGGLINSGGNLGGFVAPLLIGYLVDATGSYTAAFLFLAAVALLAA 352
|
....*.
gi 502820707 405 LSYTFL 410
Cdd:cd17319 353 LLVLLL 358
|
|
| 2A0114 |
TIGR00893 |
D-galactonate transporter; [Transport and binding proteins, Carbohydrates, organic alcohols, ... |
14-411 |
4.31e-77 |
|
D-galactonate transporter; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273326 [Multi-domain] Cd Length: 399 Bit Score: 244.94 E-value: 4.31e-77
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502820707 14 VGVVVNYFDRINMSIAMPLLQKEFNLTAGQMGIFLSAFAWSYALLQLPIGPLLDKIGVKWVTRVATVIWTVACLLTAVAN 93
Cdd:TIGR00893 1 LVTVINYLDRANLSFAAPMLQEDLGLSAAQYGYVFSAFSWGYVVGQFPGGWLLDRFGARKTLAVFIVIWGVFTGLQAFAG 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502820707 94 GWGLIILSRVLLGVGEAPFFPSAAKAVSHWVPRQERGKAIAAYDSQSKLSNAIGAPILALIVTEWGWRGGFLATAILSFI 173
Cdd:TIGR00893 81 AYVSLYILRVLLGAAEAPFFPGIILIVASWFPASERATAVSIFNSAQGLGGIIGGPLVGWILIHFSWQWAFIIEGVLGII 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502820707 174 YAIVYWIWYREPHEDERLTKEEYDYIVQGGSQSSEEAKG---SAMENIRYLLTKRKVWAVFIGFAAYGYSWFLFLTWLPG 250
Cdd:TIGR00893 161 WGVLWLKFIPDPPQKAKWLTEEEKYIVVGGLLAEQQGKGpstPKKYQIKELLKDRRVWGLALGQFLVNIGLGFFLTWFPT 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502820707 251 YLATEMNMSILKSGWYSAIPWIVGTITeIVIGGWLVDRLINKGYNRTRVSKFFLVIGMVFGLSIIGAAFTHSANVAVFWI 330
Cdd:TIGR00893 241 YLVQERGLSILEAGFMASLPGIVGFIG-MILGGRLSDLLLRRGKSLVFARKTAIIAGLVLSLLMFATNYVNIPYAALALV 319
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502820707 331 STALGGLVVTsAVAYSIPTFIAPKGTVGTLTGLLTFGNNSMAIVAPITTGFIVQATGSFMYAFLLAAAFLVIGILSYTFL 410
Cdd:TIGR00893 320 ALGFFGLGAG-AIGWALISDNAPGNIAGLTGGLINSLGNLGGIVGPIVIGAIAATTGSFAGALMVVAALALIGALSYLLL 398
|
.
gi 502820707 411 L 411
Cdd:TIGR00893 399 V 399
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
2-411 |
2.38e-68 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 221.28 E-value: 2.38e-68
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502820707 2 KKHRWSIVFLIAVGVVVNYFDRINMSIAMPLLQKEFNLTAGQMGIFLSAFAWSYALLQLPIGPLLDKIGVKWVTRVATVI 81
Cdd:COG2271 5 SRYRWRILALLFLAYFLNYLDRSNLSVAAPPLQADLGLSAAQLGLLASAFFLGYALGQIPAGLLADRFGRRRVLAIGLLL 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502820707 82 WTVACLLTAVANGWGLIILSRVLLGVGEAPFFPSAAKAVSHWVPRQERGKAIAAYDSQSKLSNAIGAPILALIVTEWGWR 161
Cdd:COG2271 85 WGLATLLFGFATSFWQLLLLRFLLGLGEAGFFPAALKLIAEWFPPKERGRALGIFNAGGPLGGALAPPLLGWLLAAFGWR 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502820707 162 GGFLATAILSFIYAIVywiwyrephederltkeeydyivqggsqsseeakgsamenirylltkrKVWAVFIGFAAYGYSW 241
Cdd:COG2271 165 AAFLILGLPGLLLALL------------------------------------------------RFWLLALAYFLVYFAL 196
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502820707 242 FLFLTWLPGYLATEMNMSILKSGWYSAIPWIVGTITeIVIGGWLVDRLINKGynrtrvsKFFLVIGMVF-GLSIIGAAFT 320
Cdd:COG2271 197 YGFLTWLPTYLVEVRGLSLAQAGLLLSLPFLAGIVG-SLLGGWLSDRLGRRR-------KLVLAIGLLLaALALLLLALL 268
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502820707 321 HSANVAVFWISTALGGLVVTSAVAYSIPTFIAPKGTVGTLTGLLTFGNNSMAIVAPITTGFIVQATGsFMYAFLLAAAFL 400
Cdd:COG2271 269 PSPALAIALLFLAGFGLGGAFGLLWALAAELFPKKARGTASGLVNTFGFLGGALGPLLVGYLLDATG-YQAAFLLLAALA 347
|
410
....*....|.
gi 502820707 401 VIGILSYTFLL 411
Cdd:COG2271 348 LLAALLALLLL 358
|
|
| MFS_SLC17A9_like |
cd17380 |
Solute carrier family 17 member 9 and similar proteins of the Major Facilitator Superfamily of ... |
9-409 |
1.49e-60 |
|
Solute carrier family 17 member 9 and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily includes solute carrier family 17 member 9 (SLC17A9) and similar proteins including plant inorganic phosphate transporters (PHT4) that are also probably anion transporters. SLC17A9, also called vesicular nucleotide transporter (VNUT), is involved in vesicular storage and exocytosis of ATP. It facilitates the accumulation of ATP and other nucleotides in secretory vesicles such as adrenal chromaffin granules and synaptic vesicles. It also functions as a lysosomal ATP transporter and regulates cell viability. Plant PHT4 family transporters mediate the transport of inorganic phosphate and may also transport organic anions. The Arabidopsis protein AtPHT4;4 is a chloroplast-localized ascorbate transporter. PHT4 proteins show differential expression that suggests specialized functions. The SLC17A9-like subfamily belongs to the Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340938 [Multi-domain] Cd Length: 361 Bit Score: 200.86 E-value: 1.49e-60
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502820707 9 VFLIAVGVVVNYFDRINMSIAMPLLQKEFNLTAGQMGIFLSAFAWSYALLQLPIGPLLDKIGVKWVTRVATVIWTVACLL 88
Cdd:cd17380 1 VILLFLATCICYADRVNMPIAIVPMAKEFGWSKTDQGLVLSSFFWGYALTQVLGGYLADRFGGKKVLLLAVALWSLATLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502820707 89 TAVANGWGL--IILSRVLLGVGEAPFFPSAAKAVSHWVPRQERGKAIAAYDSQSKLSNAIGAPILALIVTEWGWRGGFLA 166
Cdd:cd17380 81 TPLLAYSSLplLILSRILLGLGEGVHFPSMTSLFSRWVPVSERSRAVSIVTAGSYLGTLLGGLIGPLLLEYYGWPSVFYF 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502820707 167 TAILSFIYAIVYWIWYREphederltkeeydyivqggsqsseeakgsamenirylltkrkVWAVFIGFAAYGYSWFLFLT 246
Cdd:cd17380 161 FGLLGLLWALVWLIYLPP------------------------------------------VWAIIVAHFCMNWGFYILLS 198
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502820707 247 WLPGYLaTEMNMSILKSGWYSAIPWIVGTITEIViGGWLVDRLINKGYNRTRVSKFFLVIGMVF-GLSIIGAAFTHSANV 325
Cdd:cd17380 199 WLPTYF-HEVLVPLAKGWVFNVVPWLVMFPSSNV-AGWLADHLISRGWTVTSVRKLMQSIGFLGpALFLLLLSHTDSFSL 276
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502820707 326 AVFWISTALGGLVVTSAVAYSIPTFIAPK---------GTVGTLTGlltfgnnsmaIVAPITTGFIVQATGSFMYAFLLA 396
Cdd:cd17380 277 ALLCMSVALGLSAFSSSGVLVNHQDIAPNyagivfgisNTAGTIPG----------IVGVYLTGYILEATGSWSLVFVLA 346
|
410
....*....|...
gi 502820707 397 AAFLVIGILSYTF 409
Cdd:cd17380 347 AVVNLVGAVVFLL 359
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
5-405 |
5.01e-50 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 174.30 E-value: 5.01e-50
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502820707 5 RWSIVFLIAVGVVVNYFDRINMSIAMPLLQKEFNLTAGQMGIFLSAFAWSYALLQLPIGPLLDKIGVKWVTRVATVIWTV 84
Cdd:COG2223 3 RWRVLLLATLAFFLAFGVWYLWSVLAPPLAEEFGLSAAQLGLLFAIPVLVGALLRIPLGFLVDRFGPRRVLLIGLLLLGI 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502820707 85 ACLLTAVANGWGLIILSRVLLGVGEAPFFPSAAKAVSHWVPRQERGKAIAAYDSQSKLSNAIGAPILALIVTEWGWRGGF 164
Cdd:COG2223 83 GLLLLALAVSYWLLLLLGLLLGIGGGGSFAVGIALVSKWFPPDRRGLALGLAAGGGNLGAAVAAFLAPLLIAAFGWRNAF 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502820707 165 LATAILSFIYAIVYWIWYREPHEDERltkeeydyivqggsqsseEAKGSAMENIRYLLTKRKVWAVFIGFAAYGYSWFLF 244
Cdd:COG2223 163 LILGILLLVVAVLAWLFLRDPPAGAA------------------AAAKASLRDQLEALRDPRFWLLSLLYFGTFGSFIGF 224
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502820707 245 LTWLPGYLATEMNMSILKSGWYSAIPWIVGTITEIViGGWLVDRLinkgyNRTRVskfFLVIGMVFGLSIIGAAFTHSAN 324
Cdd:COG2223 225 SSWLPPYLVDQFGLSAATAGLLAALFALLGALGRPL-GGWLSDRI-----GGRRV---LLIVFALMALGLLLLALALGSL 295
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502820707 325 VAVFWISTALGGLV-VTSAVAYSIPTFIAPKGTVGTLTGLLTFGNNSMAIVAPITTGFIVQATGSFMYAFLLAAAFLVIG 403
Cdd:COG2223 296 WLFLVLFLLLGLALgGGNGAVFALVPDIFPTKNAGAVYGLVGAAGGLGGFLGPLLFGALLDATGSYTAAFLVFAVLALVA 375
|
..
gi 502820707 404 IL 405
Cdd:COG2223 376 LV 377
|
|
| 2A0104 |
TIGR00881 |
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, ... |
14-387 |
1.19e-40 |
|
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273319 [Multi-domain] Cd Length: 379 Bit Score: 148.68 E-value: 1.19e-40
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502820707 14 VGVVVNYFDRINMSIAMPLLQKEFNLTAGQMGIFLSAFAWSYALLQLPIGPLLDKIGVKWVTRVATVIWTVACLLTAVAN 93
Cdd:TIGR00881 2 IGYAAYYLVRKNFALAMPYLVEEIGLSKTDLGLLLSSFSIAYGISKFVMGSVSDRSNPRVFLPIGLILCAIVNLFFGFST 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502820707 94 GWGLIILSRVLLGVGEAPFFPSAAKAVSHWVPRQERGKAIAAYDSQSKLSNAIGAPILALIVTE-WGWRGGFLATAILSF 172
Cdd:TIGR00881 82 SLWVMAALWALNGIFQGMGWPPCGRTVTKWFSRSERGTWVSFWNCSHNVGGGLLPPLVLFGIAElYSWHWVFIVPGIIAI 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502820707 173 IYAIVYWIWYREPHEDERLTKEEYDYIVQGGSQSSEEAKGSAMENI--RYLLTKRKVWAVFIG-FAAYGYSWFlFLTWLP 249
Cdd:TIGR00881 162 IVSLICFLLLRDSPQSCGLPPAEEMPNEEPDGDAEKKEEELTKKQIflQYVLLNKVLWYISLGyVFVYVVRTG-ILDWSP 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502820707 250 GYLATEMNMSILKSGWYSAIPWIVGTITEIViGGWLVDRLINkgyNRTRVSKFFLVIGMVFGLsiIGAAFTHSANVAVFW 329
Cdd:TIGR00881 241 LYLTQEKGFSKEKASWAFTLYELGGLVGTLL-AGWLSDKLFN---GRRGPLAVFFMALIIVSL--LVYWLNPAANPLMDL 314
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|
gi 502820707 330 ISTALGGLVV--TSAVAYSIPTFIAPKGTVGTLTGLLTFGNNSMAIVAPITTGFIVQATG 387
Cdd:TIGR00881 315 ICLFALGFLVygPQMLIGVIASELAPKKAAGTAAGFVGFFAYLGGILAGLPLGYLADGFG 374
|
|
| MFS_SLC17 |
cd17318 |
Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily of transporters; The ... |
10-410 |
4.63e-40 |
|
Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily of transporters; The Solute carrier 17 (SLC17) family is primarily involved in the transport of organic anions. There are nime human proteins belonging to this family including: the type I phosphate transporters (SLC17A1-4) that were initially identified as sodium-dependent inorganic phosphate (Pi) transporters but are now known to be involved in tha transport of organic anions; lysosomal acidic sugar transporter (SLC17A5 or sialin), vesicular glutamate transporters (VGluT1#3 or SLC17A7, SLC17A6, and SLC17A8, respectively), and a vesicular nucleotide transporter (VNUT or SLC17A9). SLC17A1 and SLC17A3 have roles in the transport of urate and para-aminohippurate, respectively. The SLC17 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340876 [Multi-domain] Cd Length: 389 Bit Score: 147.38 E-value: 4.63e-40
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502820707 10 FLIAVGVVVNYFDRINMSIAM----------------------PLLQKEFNLTAGQMGIFLSAFAWSYALLQLPIGPLLD 67
Cdd:cd17318 2 ILLFLGFAVVYAMRVNLSVAIvamvnstathdnnntstdkdtlPVEAPEFDWSEKTQGIILSSFFYGYILTQIPGGYLAE 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502820707 68 KIGVKWVTRVATVIWTVACLLT--AVANGWGLIILSRVLLGVGEAPFFPSAAKAVSHWVPRQERGKAIAAYDSQSKLSNA 145
Cdd:cd17318 82 KYGAKRVLGYSILITALLTLLTplAARGGYGALIVLRILQGLAQGVTFPAMHALWAKWAPPLERSRLTSIAYSGSQFGTV 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502820707 146 IGAPILALIVTEWGWRGGFLATAILSFIYAIVYWIWYrephederltkeeydyivqggsqsseeakgsamenirylltkR 225
Cdd:cd17318 162 IAMPLSGFLCESLGWPSIFYIFGGLGLLWCLLWFFLV------------------------------------------L 199
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502820707 226 KVWAVFIGFAAYGYSWFLFLTWLPGYLATEMNMSILKSGWYSAIPWIVGTITeIVIGGWLVDRLINKG-YNRTRVSKFFL 304
Cdd:cd17318 200 PVWAIVVAHFGHNWGFYTLLTELPTYMSDVLHFNIKSNGFLSSLPYLAMWIC-SIVGGYLADWLRSRGiLSTTTVRKLFT 278
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502820707 305 VIGMVF-GLSIIGAAF---THSANVAVFWISTALGGLVVTSAVAYSIPtfIAPKGTvGTLTGLLTFGNNSMAIVAPITTG 380
Cdd:cd17318 279 SIGFLGpGVFLIALGYlgsNATLAVVFLTLSVGLSGACYSGFLVNHLD--LAPNYA-GTLMGITNTAATIAGIISPLIVG 355
|
410 420 430
....*....|....*....|....*....|...
gi 502820707 381 FIV---QATGSFMYAFLLAAAFLVIGILSYTFL 410
Cdd:cd17318 356 AIVkndQTIGQWRIVFFISAAIYILGAIFYLIF 388
|
|
| MFS_MT3072_like |
cd17475 |
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar ... |
31-405 |
6.56e-37 |
|
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar transporters of the Major Facilitator Superfamily; This family includes the Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341028 [Multi-domain] Cd Length: 378 Bit Score: 138.53 E-value: 6.56e-37
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502820707 31 PLLQKEFNLTAGQMGIFLSAFAWSYALLQLPIGPLLDKIGVKWVTRVATVIWTVACLLTAVANGWGLIILSRVLLGVGEA 110
Cdd:cd17475 20 PFLQEDLHLSLAQVGLLLSALNLGVAVSMLPAGWLLDRFGERRVLAVGLLLMGAAALLMALVGSYPVLLVLLFLVGAGYG 99
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502820707 111 PFFPSAAKAVSHWVPRQERGKAIAAYDSQSKLSNAIGAPILALIVTEWGWRGGFLATAILSFIYAIVYWIWYREPheder 190
Cdd:cd17475 100 SVQPGGGRAIMRWFPPRERGLAMGIRQTGVPLGGALAAALLPPLALHYGWRAAFVVAGLVSILAAVLFWLFYREP----- 174
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502820707 191 ltkeeydyivqGGSQSSEEAKGSAMENIRYLLTKRKVWAVFIGFAAYGYSWFLFLTWLPGYLATEMNMSILKSGWYSAIP 270
Cdd:cd17475 175 -----------PAASAATESASTLLRSLKEVLRNRDVWLIAIAGALLVAPQFALLTFLLLFLHDHLGLSVVAAGALLAVA 243
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502820707 271 WIVGTITEIViGGWLVDRLinkGYNRTRVSKFFLVIGMVFGLSIIGAAFTHSANVAVFWISTALGGLVVT-SAVAYSIPT 349
Cdd:cd17475 244 QLGGALGRIG-LGRVSDRV---FGGRRRPVLVITAAIAAAALLVLSLLSPGTPLWLLVLLLILLGLFAIGwNGLYLTLVA 319
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*.
gi 502820707 350 FIAPKGTVGTLTGLLTFGNNSMAIVAPITTGFIVQATGSFMYAFLLAAAFLVIGIL 405
Cdd:cd17475 320 ESAGPEQAGTALGLANTINFIGIAIGPPLFGLLVDATHSYAPAWLALALLLVLAAL 375
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
2-375 |
6.71e-37 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 137.80 E-value: 6.71e-37
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502820707 2 KKHRWSIVFLIAVGVVVNYFDRINMSIAMPLLQKEFNLTAGQMGIFLSAFAWSYALLQLPIGPLLDKIGVKWVTRVATVI 81
Cdd:COG2814 5 PRRRWLALLALALGAFLSGLGIGIVLPALPLIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLLL 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502820707 82 WTVACLLTAVANGWGLIILSRVLLGVGEAPFFPSAAKAVSHWVPRQERGKAIAAYDSQSKLSNAIGAPILALIVTEWGWR 161
Cdd:COG2814 85 FALGSLLCALAPSLWLLLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLADLFGWR 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502820707 162 GGFLATAILSFIYAIVYWIWYREPHederltkeeydyivqggsqssEEAKGSAMENIRYLLTKRKVWAVFIGFAAYGYSW 241
Cdd:COG2814 165 WVFLVNAVLALLALLLLLRLLPESR---------------------PAARARLRGSLRELLRRPRLLLLLLLAFLLGFGF 223
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502820707 242 FLFLTWLPGYLATEMNMSILKSGWYSAIPWIVGTITEIvIGGWLVDRLinkgynrtrvSKFFLVIGMVFGLSIIGAAFTH 321
Cdd:COG2814 224 FALFTYLPLYLQEVLGLSASAAGLLLALFGLGGVLGAL-LAGRLADRF----------GRRRLLLIGLLLLALGLLLLAL 292
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*.
gi 502820707 322 SANVAVFWISTALGGLVV--TSAVAYSIPTFIAPKGTVGTLTGLLTFGNNSMAIVA 375
Cdd:COG2814 293 AGSLWLLLLALFLLGFGFglLFPLLQALVAELAPPEARGRASGLYNSAFFLGGPLA 348
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
12-376 |
2.02e-36 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 136.39 E-value: 2.02e-36
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502820707 12 IAVGVVVNYFDRINMSIAMPL-LQKEFNLTAGQMGIFLSAFAWSYALLQLPIGPLLDKIGVKWVTRVATVIWTVACLLTA 90
Cdd:pfam07690 1 LFLAAFLAALGRSLLGPALPLlLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502820707 91 VANGWGLIILSRVLLGVGEAPFFPSAAKAVSHWVPRQERGKAIAAYDSQSKLSNAIGAPILALIVTEWGWRGGFLATAIL 170
Cdd:pfam07690 81 FASSLWLLLVLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLFGWRAAFLILAIL 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502820707 171 SFIYAIVYWIWYREPHEderltkeeydyivqGGSQSSEEAKGSAMENIRYLLTKRKVWaVFIGFAAYGYSWFLFLTWLPG 250
Cdd:pfam07690 161 SLLAAVLLLLPRPPPES--------------KRPKPAEEARLSLIVAWKALLRDPVLW-LLLALLLFGFAFFGLLTYLPL 225
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502820707 251 YlATEMNMSILKSGWYSAIPWIVGTITeIVIGGWLVDRlinkgYNRTRVSKFFLVIGMVFGLSIIGAAFTHSANVAVFWI 330
Cdd:pfam07690 226 Y-QEVLGLSALLAGLLLGLGGLLGAIG-RLLLGRLSDR-----LGRRRRLLLALLLLILAALGLLLLSLTLSSLWLLLAL 298
|
330 340 350 360
....*....|....*....|....*....|....*....|....*.
gi 502820707 331 STALGGLVVTSAVAYSIPTFIAPKGTVGTLTGLLTFGNNSMAIVAP 376
Cdd:pfam07690 299 LLLGFGFGLVFPALNALVSDLAPKEERGTASGLYNTAGSLGGALGP 344
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
12-407 |
8.17e-35 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 132.94 E-value: 8.17e-35
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502820707 12 IAVGVVVNYFDRINMSIAMPLLQKEFNLTAGQMGIFLSAFAWSYALLQLPIGPLLDKIGVKWVTRVATVIWTVACLLTAV 91
Cdd:cd06174 1 LLLGFFLTGLARGLISPLLPALLQSFGLSASQLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLFAF 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502820707 92 ANGWGLIILSRVLLGVGEAPFFPSAAKAVSHWVPRQERGKAIAAYDSQSKLSNAIGAPILALIVT--EWGWRGGFLATAI 169
Cdd:cd06174 81 APSFWLLLLGRFLLGLGSGLIDPAVLALIADLFPERERGRALGLLQAFGSVGGILGPLLGGILASslGFGWRAVFLIAAA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502820707 170 LSFIYAIVYWIWYREPHEDERLTKEeydyivqggsqssEEAKGSAMENIRYLLTKRKVWAVFIGFAAYGYSWFLFLTWLP 249
Cdd:cd06174 161 LALLAAILLLLVVPDPPESARAKNE-------------EASSKSVLKLLKRVLKNPGLWLLLLAIFLVNLAYYSFSTLLP 227
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502820707 250 GYLATEMNMSILKSGWYSAIPWIVGTITeIVIGGWLVDRLINKGYnrtrvskffLVIGMVFGLSIIGAAFTHSANVAVFW 329
Cdd:cd06174 228 LFLLDLGGLSVAVAGLLLSLFGLAGALG-SLLLGLLSDRLIGRKP---------LLLIGLLLMALGLALLLLAPSLLLLL 297
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502820707 330 ISTALGGLVV--TSAVAYSIPTFIAPKGTVGTLTGLLTFGNNSMAIVAPITTGFIVQATGSFMYAFLLAAAFLVIGILSY 407
Cdd:cd06174 298 LLLLLLGFGLggLLPLSFALIAELFPPEIRGTAFGLLNTFGFLGGAIGPLLAGFLLAATFGLTGAFLVLAVLLLLAAILL 377
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
30-411 |
1.33e-28 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 115.75 E-value: 1.33e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502820707 30 MPLLQKEFNLTAGQMGIFLSAFAWSYALLQLPIGPLLDKIGVKWVTRVATVIWTVACLLTAVANGWGLIILSRVLLGVGE 109
Cdd:cd17325 19 LPLYAESLGASVAQIGLIVAAYALAQLLFSPPAGRLSDRFGRKRLLLLGLLLLAVSTLLFAFATSYWQLLLARFLQGLAS 98
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502820707 110 APFFPSAAKAVSHWVPRQERGKAIAAYDSQSKLSNAIGAPILALIVTEWGWRGGFLATAILSFIYAIVYWIWYREPHEDE 189
Cdd:cd17325 99 AAVWPAAMALIADIAPPEERGRAMGIFSSAIGLGFLIGPLLGGLLADALGYRAPFLVCAALALLALVLALLLLPEPRPPP 178
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502820707 190 RltkeeydyivqggsqSSEEAKGSAMENIRYLLTKRKVWAVFIGFAAYGYSWFLFLTWLPGYLATEMNMSILKSGWYSAI 269
Cdd:cd17325 179 N---------------KRAVSAARLRSGLRLLLRDRRLLALFLAIFVLAFAFGALEPFLPLYAAELGGLSPAQIGLLFGA 243
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502820707 270 PWIVGTITEIvIGGWLVDRlinkgYNRTRVskffLVIGMVFGlSIIGAAFTHSANVAVFWISTALGGLV--VTSAVAYSI 347
Cdd:cd17325 244 QGLASALSQP-PAGKLSDR-----IGRKPL----ILIGLLLS-AVALLLLPLATSFWLLLLLLALLGLGlgLVFPATLAL 312
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 502820707 348 PTFIAPKGTVGTLTGLLTFGNNSMAIVAPITTGFIVQATGsFMYAFLLAAAFLVIGILSYTFLL 411
Cdd:cd17325 313 LADIVPPEGRGTAMGLFNTAFSLGMVLGPLLGGFLYDAFG-FATPFLAAAALLLLAAVLFLLLR 375
|
|
| CynX |
COG2807 |
Cyanate permease [Inorganic ion transport and metabolism]; |
30-405 |
1.12e-25 |
|
Cyanate permease [Inorganic ion transport and metabolism];
Pssm-ID: 442057 [Multi-domain] Cd Length: 399 Bit Score: 107.65 E-value: 1.12e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502820707 30 MPLLQKEFNLTAGQMGIFLSAFAWSYALLQLPIGPLLDKIGVKWVTRVATVIWTVACLLTAVANGWGLIILSRVLLGVGE 109
Cdd:COG2807 41 LPEIRADLGLSATQAGLLTTLPLLAFGLFAPLAPRLARRFGLERTLLLALLLLAAGLLLRSLAPSVALLLAGTALIGAGI 120
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502820707 110 APFFPSAAKAVSHWVPRQeRGKAIAAYDSQSKLSNAIGAPILALIVTEWGWRGGFLATAILSFIYAIVYWIWYREPHede 189
Cdd:COG2807 121 AVGNVLLPGLIKRWFPDR-VGLMTGLYTAAMGLGAALAAGLTVPLAAALGWRGALAVWALLALLALLLWLPLLRRRP--- 196
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502820707 190 rltkeeydyivqggsqsSEEAKGSAMENIRYLLTKRKVWAVFIGFAAYGYSWFLFLTWLPGYLaTEMNMSILKSGWYSAI 269
Cdd:COG2807 197 -----------------AAAAAAPAAASLRSLWRSPLAWLLTLFFGLQSLLYYAVVAWLPPIL-RDAGLSAATAGLLLSL 258
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502820707 270 PWIVGTITEIVIgGWLVDRLinkgyNRTRVSKFFLVIGMVFGLSIIGAAFTHSANVAVFWISTALGGLVVTSAVAysIPT 349
Cdd:COG2807 259 FQLAGIPGSLLV-PLLADRL-----GDRRPLLLLLGLLGLAGLLGLLLAPGSLPWLWAVLLGLGQGGLFPLALTL--IGL 330
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*.
gi 502820707 350 FIAPKGTVGTLTGLLTFGNNSMAIVAPITTGFIVQATGSFMYAFLLAAAFLVIGIL 405
Cdd:COG2807 331 RARTPAEAAALSGMAQSVGYLLAALGPLLVGALHDATGSWTAALLLLAALAVLMLV 386
|
|
| MFS_YfmO_like |
cd17474 |
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ... |
29-405 |
1.36e-25 |
|
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341027 [Multi-domain] Cd Length: 374 Bit Score: 107.27 E-value: 1.36e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502820707 29 AMPLLQKEFNLTAGQMGIFLSAFAWSYALLQLPIGPLLDKIGVKWVTRVATVIWTVACLLTAVANGWGLIILSRVLLGVG 108
Cdd:cd17474 21 ILPAIAEALGASPAQVGLLITAFTLPAAVLMPVAGVLADRFGRKKVLLPGLLLFGIGGLLCGLSDSFALLLAGRALQGIG 100
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502820707 109 EAPFFPSAAKAVSHWVPRQERGKAIAAYDSQSKLSNAIGaPILALIVTEWGWRGGFLATAILSFIYAIVYWIWYREPHED 188
Cdd:cd17474 101 AAGLGPLALTLIGDLFEGGERAKAMGLYEAALGLGIAVG-PLLGGLLAAISWRYPFFLLAALIPVAFLAILFLLPEPKEK 179
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502820707 189 ERltkeeydyivqggsQSSEEAKGSAMEniryLLTKRKVWAVFIGFAAYGYSWFLFLTWLPGYLATEMNMSILKSGWYSA 268
Cdd:cd17474 180 AK--------------SSSATKLRDLKK----ALRGRGLLTFLVSAFLYFFLYFAFLTYLPFLLELLYGISPIIIGLLFA 241
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502820707 269 IPWIVGTITEIVIGGWLVDRLInkgynrtrvSKFFLVIGMV-FGLSIIGAAFTHsaNVAVFWISTALGGLVVTSAVAySI 347
Cdd:cd17474 242 GWSVLLALGSLFVGRLLKKRFG---------ARRILVIGLLlYALSLLLLGFVP--SLALLLIAIVLFGLGLGLNLP-LL 309
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 502820707 348 PTFI---APKGTVGTLTGLLTFGNNSMAIVAPITTGFIVQATGSFMYAFLLAAAFLVIGIL 405
Cdd:cd17474 310 TTLVtelAPEEERGTASSLYNFVRFLGQAVGPLLFGLLLEIFGLSAPFLVGAAIALAAAVL 370
|
|
| MFS_NepI_like |
cd17324 |
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ... |
30-405 |
5.13e-24 |
|
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340882 [Multi-domain] Cd Length: 370 Bit Score: 102.63 E-value: 5.13e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502820707 30 MPLLQKEFNLTAGQMGIFLSAFAWSYALLQLPIGPLLDKIGVKWVTRVATVIWTVACLLTAVANGWGLIILSRVLLGVGE 109
Cdd:cd17324 22 LPDIARDFGVSVAQAGLLVSAYALGYALGALLLGPLSDRIERRRLLLVLLLLFILGNLLAALAPSFALLLLARALAGLAH 101
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502820707 110 APFFPSAAKAVSHWVPRQERGKAIAAYDSQSKLSNAIGAPILALIVTEWGWRGGFLATAILSFIyaIVYWIWYREPHede 189
Cdd:cd17324 102 GGFWAIAAAYAADLVPPEKRGRAIGLVFSGLTLGLVLGRPLGGLLGQLLGWRAAFLAIAVLALL--AALLLWRLLPS--- 176
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502820707 190 rltkeeydyivqggSQSSEEAKGSAMENIRYLLTKRKVWAVFIGFAAYGYSWFLFLTWLPGYLATEMNMSILKSGWYSAI 269
Cdd:cd17324 177 --------------LPPKKPGSLGLLSSLLLLLRNPRLRLAYLITFLLFGGFFALYTYLAPFLTDVPGFSSSAIIGLLLL 242
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502820707 270 PWIVGTITeIVIGGWLVDRlinkgYNRTRVSKFFLVIgMVFGLSIIGAAFTHSANVAVFWISTALGGLVVTSAVAYSIPt 349
Cdd:cd17324 243 FGVAGVVG-SPLAGRLADR-----GGRRALLIALLLL-AAALLLLTLLGPSPLLLLVGLVLWGLGFFAAHSALQTRVLR- 314
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*.
gi 502820707 350 fIAPKGTvGTLTGLLTFGNNSMAIVAPITTGFIVQATGsFMYAFLLAAAFLVIGIL 405
Cdd:cd17324 315 -LAPEAR-GLASSLYLAAYNLGGALGAALGGLVLDHGG-WAGVGWVGAALLLLALL 367
|
|
| FucP |
COG0738 |
Fucose permease [Carbohydrate transport and metabolism]; |
2-411 |
9.75e-24 |
|
Fucose permease [Carbohydrate transport and metabolism];
Pssm-ID: 440501 [Multi-domain] Cd Length: 391 Bit Score: 102.24 E-value: 9.75e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502820707 2 KKHRWSIVFLIAVGVVVNYFDRINMSIAMPLLQKEFNLTAGQMGIFLSAFAWSYALLQLPIGPLLDKIGVKWVTRVATVI 81
Cdd:COG0738 3 KKNYRRALIAIYLLFFLWGFATALWGPLIPALKDAFGLSDAQAGLLLFAFFLGYLLASLPAGRLIDRFGYKRGLLLGLLL 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502820707 82 WTVACLLTAVANGWGLIILSRVLLGVGEApFFPSAAKAVSHWVPRQERGKAIAAYDSQSKLSNAIGAPILALIVT---EW 158
Cdd:COG0738 83 MALGLLLFALAPSYPLLLLALFLLGLGLG-LLDVAANPYVAALGPETAASRLNLLHAFFSLGALLGPLLGGLLILlglSL 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502820707 159 GWRGGFLATAILSFIYAIVYWIWYREPHEDErltkeeydyivqggsqssEEAKGSAMENIRYLLTKRKVWAVFIGFAAYG 238
Cdd:COG0738 162 SWHLPYLILAVLLLLLALLFLRSKLPEIEEE------------------EEEAAGSAASLKSLLKNPRLLLGGLAIFLYV 223
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502820707 239 YSWFLFLTWLPGYLATEMNMSILKSGWYSAIPWIVGTITEIvIGGWLVDRLinkgyNRTRVSKFFLVIGMVFglsIIGAA 318
Cdd:COG0738 224 GAEGAIGDWLPLYLKDVLGLSEATAALGLSLFWGGMTIGRF-LGGFLLKRF-----GPVRLLRLSALLAAVG---LLLAL 294
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502820707 319 FTHSANVAVFWIstALGGLvvtsAVAYSIPTFIA------PKGTVGTLTGLLTFGNNSMAIVAPItTGFIVQATGsFMYA 392
Cdd:COG0738 295 LAPGPWLALIGL--ALVGL----GLSLMFPTIFSlaldglGKRTAAAVSAVLIMGIVGGAIGPPL-IGFLADAFG-LRAA 366
|
410
....*....|....*....
gi 502820707 393 FLLAAAFLVIgILSYTFLL 411
Cdd:COG0738 367 FLVPLVCYLL-ILLLALAL 384
|
|
| MFS_spinster_like |
cd17328 |
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; ... |
9-403 |
9.53e-22 |
|
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; The protein spinster family includes Drosophila protein spinster, its vertebrate homologs, and similar proteins. Humans contain three homologs called protein spinster homologs 1 (SPNS1), 2 (SPNS2), and 3 (SPNS3). Protein spinster and its homologs may be sphingolipid transporters that play central roles in endosomes and/or lysosomes storage. SPNS2 is also called sphingosine 1-phosphate (S1P) transporter and is required for migration of myocardial precursors. S1P is a secreted lipid mediator that plays critical roles in cardiovascular, immunological, and neural development and function. The spinster-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340886 [Multi-domain] Cd Length: 405 Bit Score: 96.54 E-value: 9.53e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502820707 9 VFLIAVGVVVNYFDRINMSIAMPLLQKEFNLTAGQMGIFLSAFAWSYALLQLPIGPLLDKIGVKWVTRVATVIWTVACLL 88
Cdd:cd17328 1 VAVLFLINLLNYMDRFTIAGVLPDIQSDFLIDDSLAGLLQTVFIISYMVLSPIFGYLGDRYNRKWILAVGILIWSAATLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502820707 89 TAVANGWGLIILSRVLLGVGEAPFFPSAAKAVSHWVPRQERGKAIAAYDSQSKLSNAIGAPILALIVTEW-GWRGGFLAT 167
Cdd:cd17328 81 SSFAPNFWQLLLFRALVGIGEASYSPIAPTIIADLFPKEKRTRALGVFYFAIPLGSGLGYVVGGLVAQATgGWRWAFRVT 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502820707 168 AILSFIYAIVYWIWYREPHederltkeeydyivQGGSQSSEEAKG---SAMENIRYLLTKRKVWAVFIGFAAYGYSWFLF 244
Cdd:cd17328 161 GVLGVLLAILLLLFVREPP--------------RGAAEGGVMAKStatSFLADLKALAKNPSFILSTLGFTAVSFVTGAL 226
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502820707 245 LTWLPGYLATEMNMSILKSGwysAIPWIVGTITEI------VIGGWLVDRLiNKGYNRTRVskffLVIGMVFGLSI---I 315
Cdd:cd17328 227 AFWAPTFFLRAFGVGDLSSA---DVGLIFGAITCIagvlgvLLGGILADRL-RRKTPRADP----LVCAVGLLAAApflF 298
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502820707 316 GAAFTHSANVAVFWISTALG--GLVVTSAVAYSIPTFIAPKGTVGTLTGLLTFGNNSMA-IVAPITTGFIVQATG----- 387
Cdd:cd17328 299 LALVLALSNLLLAWVLLFLGefLLSLNWAPVFAILLYVVIPTRRSTASAIQILLSHLLGdAGSPYLIGLISDLLRqnkds 378
|
410 420
....*....|....*....|..
gi 502820707 388 ------SFMYAFLLAAAFLVIG 403
Cdd:cd17328 379 plaeaaSLQYALLLCSFVLVLG 400
|
|
| MFS_OPA_SLC37 |
cd17312 |
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of ... |
5-412 |
4.22e-21 |
|
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of transporters; Organophosphate:Pi antiporters (OPA) are integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The OPA family is also called solute carrier family 37 (SLC37) in vertebrates. Members include glucose-6-phosphate (Glc6P) transporter (also called translocase or exchanger), glycerol-3-phosphate permease, 2-phosphonopropionate transporter, phosphoglycerate transporter, as well as membrane sensor protein UhpC from Escherichia coli. UhpC is both a sensor and a transport protein; it recognizes external Glc6P and induces transport by UhpT, and it can also transport Glc6P. Vertebrates contain four SLC37 or sugar-phosphate exchange (SPX) proteins: SLC37A1 (SPX1), SLC37A2 (SPX2), SLC37A3 (SPX3), and SLC37AA4 (SPX4). The OPA/SLC37 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340870 [Multi-domain] Cd Length: 364 Bit Score: 93.88 E-value: 4.22e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502820707 5 RWSIVFLIAVGVVVNYFDRINMSIAMPLLQKEFNLTAGQMGIFLSAFAWSYALLQLPIGPLLDKIGVKWVTRVATVIWTV 84
Cdd:cd17312 1 RWRIFLGVFLGYAAYYVCRKNFSVAKPPIVEEIGLSKDDLGIIGSAFLIAYAVGKFISGFLSDRSNIRRFMSAGLLLSAL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502820707 85 ACLLTAVANGWGLIILSRVLLGVGEAPFFPSAAKAVSHWVPRQERGKAIAAYDSQSKLSNAIGAPILALIVTEWGWRGGF 164
Cdd:cd17312 81 ANIFMGFSTSLWFFAVLWGLNGLFQSMGWPPCVKLLGNWFSKKERGTVYGIWSTSHNFGGILAPILAASLASYYGWRAAF 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502820707 165 LATAILSFIYAIVYWIWYREphederltkeeydyivqggsqsseeakgsameniryllTKRKVWAVFIGFAAYGYSWFLF 244
Cdd:cd17312 161 LVPGIVGLVVAIILFFFLRD--------------------------------------SPPYVWVLSLAYAFVYIVRYAC 202
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502820707 245 LTWLPGYLATEMNMSILKSGWYSAIPWIVGTITEIVIgGWLVDRLINkgyNRTRVSKFFLVIGMVFGLSIIGAAFTHSAN 324
Cdd:cd17312 203 LDWGPLYLYEVKGYSLIDAGWFSSLYEVGGIAGTILA-GLLSDKLFG---GRRAPIAVIYMLLMTLSLALFWFFPHNKLL 278
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502820707 325 VAVFWISTALGGLVVTSAVAYSIPTFIAPKGTVGTLTGLLTFGNNSMAIVAPITTGFIVQATGsFMYAFLLaaaFLVIGI 404
Cdd:cd17312 279 SIVLLFLIGFFVGGPINLIGGAAAQDIGRKEAAGTATGFVGLFGYLGASLAGLPLGYIIDHYG-WSTVFYF---LISAAL 354
|
....*...
gi 502820707 405 LSYTFLLT 412
Cdd:cd17312 355 LSVLLLLS 362
|
|
| MFS_GlpT |
cd17345 |
Glycerol-3-Phosphate Transporter of the Major Facilitator Superfamily of transporters; ... |
5-408 |
5.89e-21 |
|
Glycerol-3-Phosphate Transporter of the Major Facilitator Superfamily of transporters; Glycerol-3-Phosphate Transporter (also called GlpT or G-3-P permease) is responsible for glycerol-3-phosphate uptake. It is part of the Organophosphate:Pi antiporter (OPA) family of integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The GlpT group belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340903 [Multi-domain] Cd Length: 411 Bit Score: 94.23 E-value: 5.89e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502820707 5 RWSIVFLIAVGVVVNYFDRINMSIAMPLLQKEFNLTAGQMGIFLSAFAWSYALLQLPIGPLLDKIGVKWVTRVATVIWTV 84
Cdd:cd17345 1 RWQVFLGIFIGYAGYYLVRNNFSLAQPYLIEQYGLSKTEIGLIGSALSIAYGLSKFVMGNLSDRSNPKRFLAIGLILSAI 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502820707 85 ACLLTAVANGW----GLIILSRVLLGVGEAPFFPSAAKAVSHWVPRQERGKAIAAYDSQSKLSNAIGAPILAL---IVTE 157
Cdd:cd17345 81 INILIGFVPSAtssvGLMFILLFLNGWFQGMGWPPSGRTMVHWFSKKERGTWTSIWNISHNVGGGLVGPLAGLglaIFGD 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502820707 158 WGWRGGFLATAILSFIYAIVYWIWYREPHEDERLTK-EEY--DYIVQggSQSSEEAKGSAMENI--RYLLTKRKVWA--- 229
Cdd:cd17345 161 GWWRGAFIFPAIIAIIVAVIVLFLGKDTPESEGLPPiEEYkgDYPEE--ADGEEEEQELSAWEIfvKYVLKNKLLWYiai 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502820707 230 --VFIGFAAYGyswflFLTWLPGYLATEMNMSILKSGW-YSAIPW--IVGTIteivIGGWLVDRLInKGyNRTRVSKFFL 304
Cdd:cd17345 239 anVFVYLVRYG-----ILDWAPTYLSEVKGFSKAQAMWaFSLFEWaaIPGTL----LAGWLSDKLF-KG-RRAPTGIIFM 307
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502820707 305 VIgmvfglsIIGAAFTHSANVAVFWISTALGGLvvtSAVAYsIPTFI--------APKGTVGTLTGLL-TFGNNSMAIVA 375
Cdd:cd17345 308 IL-------VIVALIVYWLAPNVLVDLIALIAL---GFLIY-GPVMLiglqalelVPKKAAGTAAGLTgLFGYLGGSVLA 376
|
410 420 430
....*....|....*....|....*....|....
gi 502820707 376 PITTGFIVQATGSF-MYAFLLAAAFLVIGILSYT 408
Cdd:cd17345 377 TALIGIIVDHFGWNgGFIVLLASCILAIIFLALV 410
|
|
| MFS_FEN2_like |
cd17327 |
Pantothenate transporter FEN2 and similar transporters of the Major Facilitator Superfamily; ... |
6-405 |
8.18e-21 |
|
Pantothenate transporter FEN2 and similar transporters of the Major Facilitator Superfamily; This family is composed of Saccharomyces cerevisiae pantothenate transporter FEN2 (or fenpropimorph resistance protein 2) and similar proteins from fungi and bacteria including fungal vitamin H transporter, allantoate permease, and high-affinity nicotinic acid transporter, as well as Pseudomonas putida phthalate transporter and nicotinate degradation protein T (nicT). These proteins are involved in the uptake into the cell of specific substrates such as pathothenate, biotin, allantoate, and nicotinic acid, among others. The FEN2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340885 [Multi-domain] Cd Length: 406 Bit Score: 93.85 E-value: 8.18e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502820707 6 WSIVFLIAVGVVVNYFDRINMSIAMPL-LQKEFNLTAGQMGIFLSAFAWSYALLQLPIGPLLDKIGVKWVTRVATVIWTV 84
Cdd:cd17327 4 LFILPLLCILYFLQYLDKSNISNAAVMgMKEDLKLVGNQYNWGNTVFYVGYIIFELPGNLLLQRFPPSKWLSVFIVLWGL 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502820707 85 ACLLTAVA-NGWGLIILsRVLLGVGEAPFFPSAAKAVSHWVPRQERGKAIAAYDSQSKLSNAIGApILALIVTE------ 157
Cdd:cd17327 84 LTLLTAAVkNFGGLIAL-RFFLGLFESGVFPGFILYLGMWYKREEQAKRIAFFYAAAGLGSIFGG-LLAYGVFKilgvgg 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502820707 158 -WGWRGGFLATAILSFIYAIVYWIWYREPHEDER-LTKEEYDYIVQ--GGSQSSEEAKGSAMENIRYLLTKRKVWAVFIG 233
Cdd:cd17327 162 lAGWRWLFIIEGLITIIIGLVIFFWLPDNPSKAWfLTEEEKELAVErlRANQTGKGDQKFKWKQIKEAFKDPRTWLLFLF 241
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502820707 234 FAAYGYSWFLFLTWLPGYLaTEMNMSILKSGWYSAIPWIVGTITeIVIGGWLVDRLINKGynrtrvskFFLVIGMVFGL- 312
Cdd:cd17327 242 FFCSQITNNGISNFLPLIL-KSLGFYSLQTNLLSVPIGALGAVS-LLIAALLSDRFKKRG--------LFAIFACVLALv 311
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502820707 313 SIIGAAFTHSANVAVFWISTALGGLVVTSAVAYS-IPTFIAPKGTVGTLTGLLTFGNNSMAIVAPITtgFIVQATGSFMY 391
Cdd:cd17327 312 GSIILLAAPNPPGAYFAAYILGGGSYAGFPILLSwISSNCAGYTKRATVLAIMLIFYNVGNIVAPQI--FRAGDAPRYIP 389
|
410
....*....|....
gi 502820707 392 AFLLAAAFLVIGIL 405
Cdd:cd17327 390 GNIALLVCACVSIV 403
|
|
| ProP |
COG0477 |
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ... |
2-177 |
1.90e-19 |
|
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];
Pssm-ID: 440245 [Multi-domain] Cd Length: 295 Bit Score: 88.33 E-value: 1.90e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502820707 2 KKHRWSIVFLIAVGVVVNYFDRINMSIAMPLLQKEFNLTAGQMGIFLSAFAWSYALLQLPIGPLLDKIGVKWVTRVATVI 81
Cdd:COG0477 9 TRRRRRALLALALGTFLEGLDFTIVNVALPSIAADLGASSAQLGWIVSAYLLGRAIGLLLFGRLGDRYGRKRVLLIGLLL 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502820707 82 WTVACLLTAVANGWGLIILSRVLLGVGEAPFFPSAAKAVSHWVPRQERGKAIAAYDSQSKLSNAIGAPILALIVTEWGWR 161
Cdd:COG0477 89 FGLASLLCGLAPSPELLIAARALQGIGAGGLMPGALALIAELFPARERGRALGLWGAAIGLGLALGPLLGGLLVAALGWR 168
|
170
....*....|....*.
gi 502820707 162 GGFLATAILSFIYAIV 177
Cdd:COG0477 169 WIFLINAPLGLLALVL 184
|
|
| 2A0115 |
TIGR00895 |
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and ... |
1-383 |
2.01e-19 |
|
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273327 [Multi-domain] Cd Length: 398 Bit Score: 89.72 E-value: 2.01e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502820707 1 MKKHRWSIVFLIAVGVVVNYFDRINMSIAMPLLQKEFNLTAGQMGIFLSAFAWSYALLQLPIGPLLDKIGVKWVTRVATV 80
Cdd:TIGR00895 11 LSRYQWRAIILSFLIMLMDGYDLAAMGFAAPAISAEWGLDPVQLGFLFSAGLIGMAFGALFFGPLADRIGRRRVLLWSIL 90
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502820707 81 IWTVACLLTAVA-NGWGLIILsRVLLGVGEAPFFPSAAKAVSHWVPRQERGKAIAAYDSQSKLSNAIGAPILALIVTEWG 159
Cdd:TIGR00895 91 LFSVFTLLCALAtNVTQLLIL-RFLAGLGLGGLMPNLNALVSEYAPKRFRGTAVGLMFCGYPIGAAVGGFLAGWLIPVFG 169
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502820707 160 WRGGFLATAILSFIYAIVYWIWYREPHE----------DERLTKEEYDYIVQGGSQSSEE--AKGSAMENIRYLLTKRKV 227
Cdd:TIGR00895 170 WRSLFYVGGIAPLLLLLLLMRFLPESIDflvskrpetvRRIVNAIAPQMQAEAQSALPEQksTQGTKRSVFKALFQGKTA 249
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502820707 228 WAVFIGFAAYG---YSWFLFLTWLPgYLATEMNMSILKSGWYSAIpWIVGTITEIVIGGWLVDRLinkgynRTRVSKFFL 304
Cdd:TIGR00895 250 RITVLLWLLYFmllVGVYFLTNWLP-KLMVELGFSLSLAATGGAL-FNFGGVIGSIIFGWLADRL------GPRVTALLL 321
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502820707 305 VIGMVFgLSIIGAAFTHSAN------VAVFWISTALGGLVVTSAVAYsiPTFIAPKGtVGTLTGLLTFGnnsmAIVAPIT 378
Cdd:TIGR00895 322 LLGAVF-AVLVGSTLFSPTLllllgaIAGFFVNGGQSGLYALMALFY--PTAIRATG-VGWAIGIGRLG----AIIGPIL 393
|
....*
gi 502820707 379 TGFIV 383
Cdd:TIGR00895 394 AGYLL 398
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
9-182 |
4.69e-18 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 85.32 E-value: 4.69e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502820707 9 VFLIAVGVVVNYFDRINMSIAMPL-LQKEFNLTAGQMGIFLSAFAWSYALLQLPIGPLLDKIGVKWVTRVATVIWTVACL 87
Cdd:cd17325 201 LLALFLAIFVLAFAFGALEPFLPLyAAELGGLSPAQIGLLFGAQGLASALSQPPAGKLSDRIGRKPLILIGLLLSAVALL 280
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502820707 88 LTAVANGWGLIILSRVLLGVGEAPFFPSAAKAVSHWVPRQERGKAIAAYDSQSKLSNAIGAPILALIVTEWGWRGGFLAT 167
Cdd:cd17325 281 LLPLATSFWLLLLLLALLGLGLGLVFPATLALLADIVPPEGRGTAMGLFNTAFSLGMVLGPLLGGFLYDAFGFATPFLAA 360
|
170
....*....|....*
gi 502820707 168 AILSFIYAIVYWIWY 182
Cdd:cd17325 361 AALLLLAAVLFLLLR 375
|
|
| MFS_MMR_MDR_like |
cd17321 |
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ... |
27-411 |
2.11e-17 |
|
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340879 [Multi-domain] Cd Length: 370 Bit Score: 83.38 E-value: 2.11e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502820707 27 SIAMPLLQKEFNLTAGQMGIFLSAFAWSYALLQLPIGPLLDKIGVKWVTRVATVIWTVACLLTAVANGWGLIILSRVLLG 106
Cdd:cd17321 16 NVALPTIARDLGASPSQLQWVVNAYLLAFAALLLLAGRLGDRFGRKRVFLIGLALFGLASLLCALAPSLAFLIAARALQG 95
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502820707 107 VGEAPFFPSAAKAVSHWVPRQERGKAIAAYDSQSKLSNAIGAPILALIVTEWGWRGGFLATAILSFIYAIvywiwyreph 186
Cdd:cd17321 96 IGAAAIMPASLALIAATFPGERRGRALGLWGAVVGIGAALGPLLGGLLLELFGWRWIFLINVPIGLVALL---------- 165
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502820707 187 ederltkeeydyivqggsqsseeakgsamenirylLTKRKVWAVFIGFAAYGySWFLFLTWLPGYLATEMNMSILKSGWY 266
Cdd:cd17321 166 -----------------------------------LARTFSGAVLAAFLLGA-ALGGLLFLLPLYLQGVLGYSPLQAGLA 209
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502820707 267 SaIPWIVGTITEIVIGGWLVDRLInkgynrtrvSKFFLVIGMVF---GLSIIGAAFTHSANVAVFWISTALG-GLVVTSA 342
Cdd:cd17321 210 L-LPLALAMLVAAPLAGRLADRFG---------PRLVLVAGLLLtavGLLLLALLGADSSVWLLLPGLVLLGlGLGLFAT 279
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502820707 343 VAYSIPTFIAPKGTVGTLTGLLTFGNN-----SMAIVAPITTGFI-----------------VQATGSFMYAFLLAAAFL 400
Cdd:cd17321 280 PLTNAALSSVPKEKAGAASGILNTARQlggalGVALLGALLTAGLsanlgdsgvaallsaaaAAFAAGFHLAFLVAAALA 359
|
410
....*....|.
gi 502820707 401 VIGILSYTFLL 411
Cdd:cd17321 360 LLAALLALLLP 370
|
|
| 2A0114euk |
TIGR00894 |
Na(+)-dependent inorganic phosphate cotransporter; [Transport and binding proteins, Anions] |
35-412 |
2.44e-17 |
|
Na(+)-dependent inorganic phosphate cotransporter; [Transport and binding proteins, Anions]
Pssm-ID: 129972 [Multi-domain] Cd Length: 465 Bit Score: 83.64 E-value: 2.44e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502820707 35 KEFNLTAGQMGIFLSAFAWSYALLQLPIGPLLDKIGVKWVTRVATVIWTVACLLTAVANGWG--LIILSRVLLGVGEAPF 112
Cdd:TIGR00894 69 PNFKWSGALQGLILSSHFYGQIIIQIPVGYLAGKYVFKWSIGIGMFLSSVISIVIPWAAGGGiaLVVFCRVIQGLAQGSV 148
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502820707 113 FPSAAKAVSHWVPRQERGKAIAAYDSQSKLSNAIGAPILALIVTEWgwrGGFLATAILSFIYAIVY-WIWYREPHEDER- 190
Cdd:TIGR00894 149 SPATHKIIVKWAPPKERSRLLGMSTSGFQLGTFIFLPISGWLCESW---GGWPMIFYVFGIVGCAWsLLWFVFPADDPSi 225
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502820707 191 ---LTKEEYDYIvqggSQSSEEAKGSAMEN--IRYLLTKRKVWAVFIGFAAYGYSWFLFLTWLPGYLATEMNMSILKSGW 265
Cdd:TIGR00894 226 hpcISKFEKKYI----NSSLQGQKGSTRQSlpIKAIPKSLPVWAIWFAIFGHFWLYTILPTYLPTFISWVLRVSGKENGL 301
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502820707 266 YSAIPWIVGTITEIVIgGWLVDRLINKGYN-RTRVSKFFLVIGMVFGLSIIGAAFTHSANVAVFWISTALGGL------- 337
Cdd:TIGR00894 302 LSSLPYLFAWLCSIFA-GYLADFLKSSKTLsLTAARKIFNGIGGLGPGIFAYALPYLSAAFYLTIIILTLANAvssgpla 380
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 502820707 338 -VVTSAVAYSiPTFIAPKGTVGTLTGLLTfgnnsmAIVAPITTGFIVQ--ATGSFMYAFLLAAAFLVIGILSYTFLLT 412
Cdd:TIGR00894 381 gVLINSLDLA-PRFLGFIKGITGLPGFIG------GLIASTLAGNILSqdSKNVWLIVFLIMAFVNILCVIFYLIFGS 451
|
|
| MFS_MdfA_MDR_like |
cd17320 |
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major ... |
29-408 |
5.07e-17 |
|
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as MdfA (also called chloramphenicol resistance pump Cmr), EmrD, MdtM, MdtL, bicyclomycin resistance protein (also called sulfonamide resistance protein), and the uncharacterized inner membrane transport protein YdhC. EmrD is a proton-dependent secondary transporter, first identified as an efflux pump for uncouplers of oxidative phosphorylation. It expels a range of drug molecules and amphipathic compounds across the inner membrane of E. coli. Similarly, MdfA is a secondary multidrug transporter that exports a broad spectrum of structurally and electrically dissimilar toxic compounds. These MDR transporters are drug/H+ antiporters (DHA) belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340878 [Multi-domain] Cd Length: 379 Bit Score: 82.24 E-value: 5.07e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502820707 29 AMPLLQKEFNLTAGQMGIFLSAFAWSYALLQLPIGPLLDKIGVKWVTRVATVIWTVACLLTAVANGWGLIILSRVLLGVG 108
Cdd:cd17320 21 ALPAIARDLGASASAVQLTLSAYLLGFALGQLLYGPLSDRFGRRPVLLAGLLLFILASLLCALASSIEQLLIARFLQGLG 100
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502820707 109 EAPFFPSAAKAVSHWVPRQERGKAIaaydsqSKLSNAIG-APILA-----LIVTEWGWRGGFLATAILSFIYAIVYWIWY 182
Cdd:cd17320 101 AAAGSVVARAIVRDLYSGAELAKIF------SLLMMILAiAPALApllggLLLLFFGWRAIFVFLALLGLLLLLLVLLFL 174
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502820707 183 REPHEDERltkeeydyivqggsqsSEEAKGSAMENIRYLLTKRKVWAVFIGFAAYGYSWFLFLTWLPGYLATEMNMSILK 262
Cdd:cd17320 175 PETLPEEK----------------RKPLLSSLLRAYKRVLKNRRFLGYALALGLSFAGLFAYLAAAPFIYIEQLGLSPAQ 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502820707 263 SGWysaipWIVGTITEIVIGGWLVDRLINKgYNRTRVSKFFLVIGMVFGLSIIGAAFTHSANVAVFW--ISTALGGLVVT 340
Cdd:cd17320 239 FGL-----LFALNAIALILGSLLNGRLVRR-FGPRRLLRLGLLLLLAAALVLLLAALLGGLSLWPLVapLFLIFFGFGLI 312
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 502820707 341 SAVAYSIPTFIAPKGTvGTLTGLLTFGNNSMAIVAPITTGFIVQATGSFMYAFLLAAAFLVIGILSYT 408
Cdd:cd17320 313 FPNATSLALEPFPHVA-GTASALLGFLQFLIGALAGALVGLLPNGTALPMGLLILVLGLLALLLLILL 379
|
|
| MFS_SLC17A6_7_8_VGluT |
cd17382 |
Solute carrier family 17 members 6, 7, and 8 (also called Vesicular glutamate transporters) of ... |
34-410 |
8.40e-17 |
|
Solute carrier family 17 members 6, 7, and 8 (also called Vesicular glutamate transporters) of the Major Facilitator Superfamily of transporters; This subfamily is composed of solute carrier family 17 member 6 (SLC17A6), SLC17A7, SLC17A8, and similar proteins. SLC17A6 is also called vesicular glutamate transporter 2 (VGluT2), differentiation-associated BNPI, or differentiation-associated Na(+)-dependent inorganic phosphate cotransporter. SLC17A7 is also called VGluT1 or brain-specific Na(+)-dependent inorganic phosphate cotransporter. SLC17A8 is also called VGluT3. They mediate the uptake of glutamate into synaptic vesicles at presynaptic nerve terminals of excitatory neural cells, and may also mediate the transport of inorganic phosphate. VGluTs are also expressed and localized in various secretory vesicles in non-neuronal peripheral organelles such as hormone-containing secretory granules in endocrine cells, and thus, also act as metabolic regulators. The VGluT subfamily belongs to the Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340940 [Multi-domain] Cd Length: 380 Bit Score: 81.62 E-value: 8.40e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502820707 34 QKEFNLTAGQMGIFLSAFAWSYALLQLPIGPLLDKIGVKWVTRVATVIWTVACLLTAVAN--GWGLIILSRVLLGVGEAP 111
Cdd:cd17382 41 KAEFNWTPETVGLIESSFFWGYLVTQIPGGFIAAKFAANRVFGLAIFVTSTLNMLIPIAArvHYGCVIFVRILQGLVEGV 120
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502820707 112 FFPSAAKAVSHWVPRQERGKAIAAYDSQSKLSNAIGAPILALIVTEWGWRGGFlatailsFIYAIVYWIWYrephederl 191
Cdd:cd17382 121 TYPACHGIWRKWAPPLERSRLATTAFCGSYAGAVVGMPLSGILVQYVGWSSPF-------YVYGVFGIIWY--------- 184
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502820707 192 tkeeydyivqggsqsseeakgsamenIRYLLTKRKVWAVFIGFAAYGYSWFLFLTWLPGYLATEMNMSILKSGWYSAIPW 271
Cdd:cd17382 185 --------------------------MFWMLVSMPVYAIIVANFCRSWTFYLLLISQPAYFKEVFGFDISKVGILSALPH 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502820707 272 IVGTITeIVIGGWLVDRLINKGY-NRTRVSKFFLVIGM-VFGLSIIGAAFTHSANVAVFWISTALG--GLVVTsavAYSI 347
Cdd:cd17382 239 LVMTII-VPIGGQLADYLRSRGIlSTTAVRKIFNCGGFgMEATFLLVVAFSHSPTVAISFLVLAVGfsGFAIS---GFNV 314
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 502820707 348 PTF-IAPK---------GTVGTLTGlltfgnnsmaIVAPITTGFIVQA--TGSFMYAFLLAAAFLVIGILSYTFL 410
Cdd:cd17382 315 NHLdIAPRyasilmgisNGIGTLSG----------MVCPVIVGALTKHktREEWQYVFLIASLVHFFGVIFYAIF 379
|
|
| MFS_SV2_like |
cd17316 |
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ... |
9-405 |
9.86e-17 |
|
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340874 [Multi-domain] Cd Length: 353 Bit Score: 81.11 E-value: 9.86e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502820707 9 VFLIAVGVVVNYFDRINMSIAMPLLQKEFN--LTAGQMGIFLSAFAWSYALLQLPIGPLLDKIGVKWVTRVATVIWTVAC 86
Cdd:cd17316 1 LLLAGLGWFFDAYDFFLIGFVAPVLAAEFSlgLSLLQTGLLFAAGFLGRPIGALLFGYLGDRIGRKKALILTLLLFGLAT 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502820707 87 LLTAVANGWGLIILSRVLLGVGEAPFFPSAAKAVSHWVPRQERGKAIAAYDSQSKLSNAIGAPILALIVT----EWGWRG 162
Cdd:cd17316 81 LLIGLLPTPILLLVLRFLQGIGIGGEYPGASTYVAEFAPSKRRGFALGLLQSGWALGALLAALVASLLIPllsgDWGWRI 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502820707 163 GFLATAILSFiyaIVYWIWYRephederltkeeydyivqggsqsseeakgsamenirylltkrkVWAVFIGFAAYGYSWF 242
Cdd:cd17316 161 LFLIGALPAL---LALLLRRR-------------------------------------------TLLLILLWFFISFGYY 194
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502820707 243 LFLTWLPGYLATEMNMSILKSGWYSAIPWIVGTITeIVIGGWLVDRLinkgyNRTRVSKFFLVIGMVFGLsIIGAAFTHS 322
Cdd:cd17316 195 GLTTFLPTYLQTVLGLSPATSSLYLLLISLGALVG-ALIAGLLSDRI-----GRKKTLVIGLILSGILAL-PLFYLLSGS 267
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502820707 323 ANVAVFWISTALGGLVVTSAVAYSIPTFIAPKGTVGTLTGLLTFGNNSMAIVAPITTGFIVQATGSFMYAFLLAAAFLVI 402
Cdd:cd17316 268 PTLLLLLLFILSFFVGGVWGALYAYLAELFPTEVRATGVGLSYNLGRLGGGGAPPLIALLLASTGGTGVPALILALLAIV 347
|
...
gi 502820707 403 GIL 405
Cdd:cd17316 348 ALI 350
|
|
| MFS_PcaK_like |
cd17365 |
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator ... |
9-405 |
1.43e-16 |
|
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator Superfamily; This aromatic acid:H(+) symporter subfamily includes Acinetobacter sp. 4-hydroxybenzoate transporter PcaK, Pseudomonas putida gallate transporter (GalT), Corynebacterium glutamicum gentisate transporter (GenK), Nocardioides sp. 1-hydroxy-2-naphthoate transporter (PhdT), Escherichia coli 3-(3-hydroxy-phenyl)propionate (3HPP) transporter (MhpT), and similar proteins. These transporters are involved in the uptake across the cytoplasmic membrane of specific aromatic compounds such as 4-hydroxybenzoate, gallate, gentisate (2,5-dihydroxybenzoate), 1-hydroxy-2-naphthoate, and 3HPP, respectively. The PcaK-like aromatic acid:H(+) symporter subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340923 [Multi-domain] Cd Length: 351 Bit Score: 80.71 E-value: 1.43e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502820707 9 VFLIAVGVVVNYFDRINMSIAMPLLQKEFNLTAGQMGIFLSAFAWSYALLQLPIGPLLDKIGVKWVTRVATVIWTVACLL 88
Cdd:cd17365 1 LALCFLIIVLDGFDLAVMGFVAPALAQDWGLSPAQLGPVGSAALFGMAIGALLAGPLADRFGRKRVLLVSVALFGLFTLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502820707 89 TAVANGWGLIILSRVLLGVGEAPFFPSAAKAVSHWVPRQERGKAIAAYDSQSKLSNAIGAPILALIVTEWGWRGGFLATA 168
Cdd:cd17365 81 TAFAQSVLQLALLRFLTGLGLGAAMPNAITLVSEYAPARRRSLAVTLMFCGYPLGAALGGFLAAALIPAFGWRSVFLLGG 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502820707 169 ILSFIYAIVywiwyrephederltkeeydyivqggsqsseeAKGSAMenirylltkrkVWAVFigFAAYGySWFLFLTWL 248
Cdd:cd17365 161 VPPLILLPL--------------------------------LRGTLL-----------LWVTF--FMGLL-LVYLLNSWL 194
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502820707 249 PgYLATEMNMSILKSGWYSAIPWIVGTITeIVIGGWLVDRlinkgYNRTRVSKFFLVIGMVFgLSIIGAAFTHSANVAVF 328
Cdd:cd17365 195 P-KLMVEAGYSLSQALTITLLLNIGGVIG-SLLLGWLADR-----FGPKRVLALFFALGAVS-LALLGVSPASLVLLYVL 266
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502820707 329 ------WISTALGGLVVTSAVAYsiPTFIAPKGtVGTLTGLLTFGnnsmAIVAPITTGFIVQATGSFMYAFLLAAAFLVI 402
Cdd:cd17365 267 vflagaCVNGAQVGLYALAARFY--PTEVRATG-VGWALGVGRLG----AILGPLLGGLLLAAGLGPESVFLALAIPAAL 339
|
...
gi 502820707 403 GIL 405
Cdd:cd17365 340 GAL 342
|
|
| MFS_SLC17A5 |
cd17381 |
Solute carrier family 17 member 5 (also called sialin) of the Major Facilitator Superfamily of ... |
35-408 |
2.16e-16 |
|
Solute carrier family 17 member 5 (also called sialin) of the Major Facilitator Superfamily of transporters; Solute carrier family 17 member 5 (SLC17A5) is also called sialin, H(+)/nitrate cotransporter, H(+)/sialic acid cotransporter (AST), membrane glycoprotein HP59, or vesicular H(+)/aspartate-glutamate cotransporter. It transports glucuronic acid and free sialic acid out of the lysosome after its cleavage from sialoglycoconjugates, which is required for normal CNS myelination. It also mediates the membrane potential-dependent uptake of aspartate and glutamate into synaptic vesicles and synaptic-like microvesicles. In the plasma membrane, it functions as a nitrate transporter. Recessive mutations in the SLC17A5 gene cause the allelic disorders, Infantile sialic acid storage disease (ISSD) and Salla disease (a predominantly neurological disorder). SLC17A5 belongs to the Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340939 [Multi-domain] Cd Length: 397 Bit Score: 80.59 E-value: 2.16e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502820707 35 KEFNLTAGQMGIFLSAFAWSYALLQLPIGPLLDKIGVKWVTRVATVIWTVACLLTAVAN--GWGLIILSRVLLGVGEAPF 112
Cdd:cd17381 58 KKYDWDAETQGWILGSFFYGYIITQIPGGYLASKIGGKLLLGFGILGTAVFTLLTPLAAdlGAGYLIAVRALEGLGEGVT 137
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502820707 113 FPSAAKAVSHWVPRQERGKAIAAYDSQSKLSNAIGAPILALIVTEWGWRGGFLATAILSFIYAIvYWIWYREPhederlt 192
Cdd:cd17381 138 FPAMHAMWASWAPPLERSRLLTISYAGAQLGTVVSLPLSGLICYYLDWTYVFYIFGAVGLLWFF-LWIWLVMP------- 209
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502820707 193 keeydyivqggsqsseeakgsamenirylltkrkVWAVFIGFAAYGYSWFLFLTWLPGYLATEMNMSILKSGWYSAIPWI 272
Cdd:cd17381 210 ----------------------------------LWAIVVAHFSYNWTFYTLLTLLPTYMKEILRFDIQENGFLSALPYL 255
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502820707 273 VGTITeIVIGGWLVDRLINKGYNRTR-VSKFFLVIGMVF-GLSIIGAAFT---HSANVAVFWISTALGGLvvtSAVAYSI 347
Cdd:cd17381 256 GCWLF-MILSGQIADNLREKQNFSTVcVRKIFTLIGMIGpAVFLLAAGFTgcnYSLAVAFLTISSTLGGF---SASGFNI 331
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 502820707 348 PTF-IAPKgTVGTLTGLLTFGNNSMAIVAPITTGFIVQ--ATGSFMYAFLLAAAFLVIGILSYT 408
Cdd:cd17381 332 NHLdIAPS-YAGILLGITNTFATIPGMVGPVIAKSLTHnnTVEEWQTVFYISAAINVFGAIFFT 394
|
|
| MFS_MdtH_MDR_like |
cd17329 |
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ... |
12-409 |
5.94e-16 |
|
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340887 [Multi-domain] Cd Length: 376 Bit Score: 78.81 E-value: 5.94e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502820707 12 IAVGVVVNYFDRINMSIAMPL----LQKEFNLTAGQMGIFLSAFAWSYALLQLPIGPLLDKIGVKWVTRVATVIWTVACL 87
Cdd:cd17329 1 LWVLLIGSFLNRLGFFMVWPFmaiyLHQQLGLSASIVGLVLALSAVAGIVASLIGGRLADRFGRKPVMLAGLLLRALGFA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502820707 88 LTAVANGWGLIILSRVLLGVGEAPFFPSAAKAVSHWVPRQERGKAIAAYDSQSKLSNAIGaPILALIVTEWGWRGGFLAT 167
Cdd:cd17329 81 LLGFAHSPWLFAIALVLTGFGGGLFEPASEAMIADVTTPENRTRAFSLLYWAINLGVAIG-PLLGGLLLLYSFRLLFLAA 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502820707 168 AILSFIYAIVYWIWYREPhederltkeeydyivqgGSQSSEEAKGSAMENIRYLLTKRKVWAVFIGFAAYGYSWFLFLTW 247
Cdd:cd17329 160 AVLFLLAALVLLFLLPET-----------------RPKRRAAEKTEILRGYKIVLRDRAFLLFLLASFLISLIYFQLEST 222
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502820707 248 LPGYLATEMNMSILKSGWYSAIPWIVgtiteIVIGGWLVDRLINKGYnrtrvSKFFLVIGMV-FGLSIIGAAFthSANVA 326
Cdd:cd17329 223 LPVYVVEILGLGESLLGLLLALNALL-----IVLLQFPVARLVERFR-----LRKILMIGILlFAIGFAVLAF--ANTLA 290
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502820707 327 VFWISTA---LGGLVVTSAVAYSIPTfIAPKGTVGTLTGLLTFGNNSMAIVAPITTGFIVQATGSFMYAFLLAAAFLVIG 403
Cdd:cd17329 291 VLILAMIvltLGEMLVFPAVQTLVAA-LAPPDKRGSYMGFYALAWGLGRAIGPLVGGLLLDLLGPGLPWLILAALGLIAA 369
|
....*.
gi 502820707 404 ILSYTF 409
Cdd:cd17329 370 ALLLGL 375
|
|
| MFS_arabinose_efflux_permease_like |
cd17473 |
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ... |
29-411 |
6.78e-16 |
|
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341026 [Multi-domain] Cd Length: 374 Bit Score: 78.77 E-value: 6.78e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502820707 29 AMPLLQKEFNLTAGQM-GIFLSAFAWSYALLQLPIGPLLDKIGVKWVTRVATVIWTVACLLTAVANGWGLIILSRVLLGV 107
Cdd:cd17473 21 ALPAIAQHFVPNSELLvPLLLTLPALFIALFAPLAGWLADRFGRKRLLIAGLLLYGIGGVAGLFLDSLYALLASRALLGI 100
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502820707 108 GEAPFFPSAAKAVSHWVPRQERGKAIAAYDSQSKLSNAIgAPILALIVTEWGWRGGFLATAiLSFIYAIVYWIWYREPhe 187
Cdd:cd17473 101 GVAGIMTLATALIGDYFEGEERAKMLGLQSAAMSLGGVV-FLLLGGALAEIGWRAPFLVYL-LALPVLILVLLFLPEP-- 176
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502820707 188 derltkeeydyivqggSQSSEEAKGSAMENIRYLLTKRKVWAVFIGFAAYgYSWFLFLTWLPGYLATEMNMSILKSGWYS 267
Cdd:cd17473 177 ----------------ARKSKSAASPGAATAAALPWKRVLPIYFLAFLAM-LLFYVIPIQLPFLLQERGGGSAALIGLAL 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502820707 268 AIPWIVGtiteiVIGGWLVDRLinkgYNRTRVSKFFLVIGMVFGLSIIGAAFTHSANVAVfwistaLGGLVVTSAVAYSI 347
Cdd:cd17473 240 AIASLAG-----AIGALLFGRL----KRRLGKRRLLAIGFALMALGFLLLALASGLWVVL------LGAILAGLGFGLLL 304
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502820707 348 PTF------IAPKGTVGTLTGLLTFGNNSMAIVAPITTGFIVQATGSFMYAFLLAAAFLVIGILSYTFLL 411
Cdd:cd17473 305 PTLnswamsLVPPELRGRAMGIVTSAFFLGQFLSPLVLGPLVNLTGGLSGAFLILGVLALVLAIVLLLLR 374
|
|
| MFS_YcxA_like |
cd17355 |
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of ... |
9-405 |
8.98e-16 |
|
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of transporters; This group is composed of uncharacterized bacterial MFS-type transporters including Bacillus subtilis YcxA and YbfB. YcxA has been shown to facilitate the export of surfactin in B. subtilis. The YcxA-like group belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340913 [Multi-domain] Cd Length: 386 Bit Score: 78.47 E-value: 8.98e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502820707 9 VFLIAVGVVVNYFdrinmSIAMPLLQKEFNLTAGQMGIFLSAFAWSYALLQLPIGPLLDKIGVKWVTRVATVIWTVACLL 88
Cdd:cd17355 10 LILILSWGIRYYF-----GVFIIPIIAEFGWSRAVISLAFTVGLLAFGLAQPFVGRLLDRFGPRRVMLLGLLLLAAGLVL 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502820707 89 TAVA-NGWGLIILSRVLLGVGEAPFFPSAAKAVSHWVPRQERGKAIAAYDSQSKLSNAIGAPILALIVTEWGWRGGFLAT 167
Cdd:cd17355 85 LALAtSLWQLYLLWGLLGGGGAGTLAAVAFATVAAWWFERRRGLALGILTAGGGLGSLVFLPLGAALIEAFGWRTALLVL 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502820707 168 AILSFIYAIVYWIWYREPHEDERLTKEeydyiVQGGSQSSEEAKGSAMENIRYlltkrkvWAVFIGFAAYGYSWFLFLTW 247
Cdd:cd17355 165 ALLALLVLVPVLLLLRRRPADLALRAY-----DDASPASPGSTLKEALRSASF-------WLLALAFFLCGFAVVGLIVH 232
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502820707 248 LPGYLAtEMNMSILKSGWYSAIPWIVGTITEIVIGgWLVDRlinkgYNRTRVSkffLVIGMVFGLSIIGAAFTHSAN--V 325
Cdd:cd17355 233 LVPYLA-DRGISPAAAAVALALIGLFNIVGRLLSG-WLGDR-----YSPRRLL---AASYALRALGLALLLLLPFPPlaL 302
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502820707 326 AVFWISTALGGLVVTSAVAYSIPTFIAPKgTVGTLTGLLTFGNNSMAIVAPITTGFIVQATGSFMYAFLLAAAFLVIGIL 405
Cdd:cd17355 303 LLFAALFGLGWGATVPLTAALAARYFGAR-SYGTLFGLVFAPHQLGSALGPWLGGLLYDRTGSYTAAWALAVALGLIAAL 381
|
|
| MFS_YfcJ_like |
cd17489 |
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ... |
30-411 |
1.93e-15 |
|
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341042 [Multi-domain] Cd Length: 367 Bit Score: 77.25 E-value: 1.93e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502820707 30 MPLLQKEFNLTAGQMGIFLSAFAWSYALLQLPIGPLLDKIGVKWVTRVATVIWTVACLLTAVANGWGLIILSRVLLGVGE 109
Cdd:cd17489 19 LPLYAHDLGGSEAVAGLVVGLFTLAALLARPFAGRLLDRFGRKRLLLIGLLIFALATLLYLLATSVALLLVLRLIHGIGW 98
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502820707 110 APFFPSAAKAVSHWVPRQERGKAIAAYDSQSKLSNAIGAPILALIVTEWGWRGGFLATAILSFIYAIVYWIWYREPHEDE 189
Cdd:cd17489 99 GAFTTAAATLVADIIPPSRRGEGIGYYGLATTLAMALGPALGLFLYQHLGFAVLFIVAAVLALLALLLVFLVKDPPPVAA 178
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502820707 190 RLTKEEYDYivqggsqsseeakgsameniRYLLTKRKVWAVFIGFAAYGYSWFLFLTWLPGYLATEmnmSILKSGWYSAI 269
Cdd:cd17489 179 EEAEAGTRA--------------------FRRLVEKKVLPPALILFLASIAYGAISTFLPLYAAER---GISNAGLFFTV 235
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502820707 270 PWIVGTITEIVIgGWLVDRlinkgYNRTRVSKFFLVIgmvFGLSIIGAAFTHSANVAVfwISTAL----GGLVVTSAVAY 345
Cdd:cd17489 236 YAIALLLSRPFS-GKLSDR-----KGPKTVIIPGLLL---LALGLLLLSFAGSPWMLL--LAAVLyglgFGLLFPALQAL 304
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 502820707 346 SIptFIAPKGTVGTLTGLLTFGNNSMAIVAPITTGFIVQATGsFMYAFLLAAAFLVIGILSYTFLL 411
Cdd:cd17489 305 AV--DLVPPHRRGAANGTFFIFFDLGIGLGGLLLGLVAELFG-YRAMFLLAAVVVLLALVLYIFLL 367
|
|
| MFS_FsR |
cd17478 |
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ... |
27-405 |
2.03e-15 |
|
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341031 [Multi-domain] Cd Length: 365 Bit Score: 77.21 E-value: 2.03e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502820707 27 SIAMPLLQKEFNLTAGQMGIFLSAFAWSYALLQLPIGPLLDKIGVKWVTRVATVIWTVACLLTAVANGWGLIILSRVLLG 106
Cdd:cd17478 16 PALLPLLIAKLGLSYAQAGLLVSVFSITSSLLQPLFGYLADRKPRRYLLPLGPLLTGLGLSLLGFAPNYWLLLLLVALAG 95
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502820707 107 VGEAPFFPSAAKAVSHwVPRQERGKAIAAYDSQSKLSNAIGAPILALIVTEWGWRGGFLATAILSFIYAIVYWIWYREPH 186
Cdd:cd17478 96 IGSAAFHPEGARLASQ-AAGGRRGLAMSIFSVGGNLGFALGPLIAAALVALFGGLGLLILLIIPGLAVALLLLRLRPLKK 174
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502820707 187 EderltkeeydyivqggsqsSEEAKGSAMENIRYLLTKRKVWAVFIGFaAYGYSWFL--FLTWLPGYLaTEMNMSILKSG 264
Cdd:cd17478 175 P-------------------EAKKAAAKSSARSTLKGVWRALLLLLII-VFLRSWVLssLTTFLPFYL-VQRGYSLVFAG 233
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502820707 265 WYSAIPWIVGTITeIVIGGWLVDRlinkgYNRTRVskffLVIGMVfgLSIIGAAFTHSANVAVFWISTALGGLVVTSAVA 344
Cdd:cd17478 234 LLLSLFLFAGAIG-TLIGGPLSDR-----FGRRRV----IIASLL--LAAPFLLLFLLTPGIWSYILLVLAGFLLFASFP 301
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 502820707 345 YSIPTF--IAPKGtVGTLTGL-LTFGNNSMAIVAPItTGFIVQATGsFMYAFLLAAAFLVIGIL 405
Cdd:cd17478 302 VTVVLAqeLLPGN-VGLASGLmMGLSFGLGGIGAPV-LGALADAFG-LESVLLILALLPLLGAL 362
|
|
| MFS_MMR_MDR_like |
cd17504 |
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) ... |
11-406 |
7.44e-14 |
|
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of putative multidrug resistance (MDR) transporters including Chlamydia trachomatis antiseptic resistance protein QacA_2, and Serratia sp. DD3 Bmr3. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341047 [Multi-domain] Cd Length: 371 Bit Score: 72.61 E-value: 7.44e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502820707 11 LIAVGVVVNYFDRInMSIAMPLLQKEFNLTAGQMGIFLSAFAWSYALLQLPIGPLLDKIGVKWVTRVATVIWTVACLLTA 90
Cdd:cd17504 1 LALAALAVMLVETM-LSPALPTIQREFGTSAAAVSWVLTAYLLVGAVSTPILGRLGDLYGRKKVLLIVLAIYTAGSLLAA 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502820707 91 VANGWGLIILSRVLLGVGeAPFFPSAAKAVSHWVPRQERGKAIAAYDSQSKLSNAIGAPILALIVTEWGWRGGFLATAIL 170
Cdd:cd17504 80 FAPNLPVLIAGRALQGIG-GAVFPLAFALVREEFPPERVPVAQGILSATFGIGAGIGLPLGGWIVQHLGWRWIFWTAAPV 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502820707 171 SFIYAIVywiwyrephederltkeeydyivqggsqsseeakgSAMENIRyLLTKRKVWAVFIGFAAYGYSWFLFLTWLPG 250
Cdd:cd17504 159 AVLLAAL-----------------------------------VPLIDLR-LLRRRNVLLANITALLAGFGMFMVFQLLPQ 202
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502820707 251 YL----ATEMNMSILKSGWYsAIPWIVGTIteivIGGWLVDRLINKgynrtRVSKFFLVIGMVF-GLSIIGAAFTHSANV 325
Cdd:cd17504 203 LLqlptPTGFGLGITEAGLL-LLPGALVML----IAGPLAGRLIAR-----VGPRRVLLIGLVIsAVGLLLLALLHSSLW 272
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502820707 326 AVFWISTALG-GLVVTSAVAYSIPTFIAPKGTVGTLTGLLTFGNNSMAIVAPITTGFI------------VQATGSFMYA 392
Cdd:cd17504 273 ALVVALLLIGiGLGLAFASLPNIVVESVPPDRTGIATGMNTVLRTIGSAIGPAIAGAIlttytvsitsggVPTEGAYVLA 352
|
410
....*....|....
gi 502820707 393 FLLAAAFLVIGILS 406
Cdd:cd17504 353 FLIGAALALAALLL 366
|
|
| MFS_Azr1_MDR_like |
cd17502 |
Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance ... |
29-410 |
2.59e-13 |
|
Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including various Saccharomyces cerevisiae proteins such as azole resistance protein 1 (Azr1p), vacuolar basic amino acid transporter 1 (Vba1p), vacuolar basic amino acid transporter 5 (Vba5p), and Sge1p (also known as Nor1p, 10-N-nonyl acridine orange resistance protein, and crystal violet resistance protein). MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341045 [Multi-domain] Cd Length: 337 Bit Score: 70.67 E-value: 2.59e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502820707 29 AMPLLQKEFNlTAGQMGIFLSAFAWSYALLQLPIGPLLDKIGVKWVTRVATVIWTVACLLTAVANGWGLIILSRVLLGVG 108
Cdd:cd17502 18 ALPTIVAEFG-GLSLVSWVGTAYLLTSTAFQPIYGKLSDLFGRKWVLLIAIVIFELGSLLCGLAPNMTMLIVGRAIQGIG 96
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502820707 109 EAPFFPSAAKAVSHWVPRQERGKAIAAYDSQSKLSNAIGAPILALIVTEWGWRGGFLATAILSFIYAIVYwiwyrephed 188
Cdd:cd17502 97 GGGLMSLAFIIIADLVPPRERGKYQGYIGAVFGIASVAGPLIGGAFTDHLSWRWCFYINLPIGGLALALL---------- 166
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502820707 189 erltkeeydyivqggsqsseeakgsamenirylltkRKVWAVFIGFAAYGYSWFLFLTWLPGYLATEMNMSILKSGwYSA 268
Cdd:cd17502 167 ------------------------------------RTILLSSIFGFLFGGALFGLIYYLPLYFQLVLGDSATKSG-VRL 209
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502820707 269 IPWIVGTITEIVIGGWLVdrlinkgyNRTRVSKFFLVIGMVFGL--SIIGAAFTHSANVAVFWISTALGGLvvtsAVAYS 346
Cdd:cd17502 210 LPLIIGLVIGSIISGALI--------SKTGRYKPLIVIGTILMSvgAGLLTTLTLDTSKWLLIGYLILLGL----GLGIG 277
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502820707 347 IPTFI------APKGTVGTLTGLLTFGNNSMAIVapittgfivqaTGSFMYAFLLAAAFLVIGILSYTFL 410
Cdd:cd17502 278 FQQPLvavqnaVPPADVGVATATNTFFRSLGGTL-----------GVAITDVFLVALALAALAFLLSLFL 336
|
|
| MFS_MefA_like |
cd06173 |
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ... |
27-409 |
3.26e-13 |
|
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340863 [Multi-domain] Cd Length: 383 Bit Score: 70.72 E-value: 3.26e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502820707 27 SIAMPLLQKEFNLTAGQMGIFLSAFAWSYALLQLPIGPLLDKIGVKWV------TRVATVIWTVACLLTAVANGWGLIIL 100
Cdd:cd06173 19 TVALPWLVLQLTGSALLVGLVLAAFFLPFLLFSPFAGVLADRFDRRRLliladlLRALLAAVLALLALLGSLSLWLLLVL 98
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502820707 101 SrVLLGVGEAPFFPSAAKAVSHWVPRQERGKAIAAYDSQSKLSNAIGAPILALIVTEWGWRGGFLATAILSFIYAIVYWI 180
Cdd:cd06173 99 A-FLLGIASAFFGPARQALLPELVPKEQLVRANALNSLATQLARIIGPALGGLLVALLGPGGAFAINALSFLLSALLLLF 177
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502820707 181 WYREPHEDERltkeeydyivqggsQSSEEAKGSAMENIRYLLTKRKVWAVFIGFAAYGYSWFLFLTWLPGYLATEMNMSI 260
Cdd:cd06173 178 IRRPPPAAPG--------------ESSSLLLRDLREGLRYLRRSPLLRLLLLALALFALLGGALTVLLPLLAKEVLGGGA 243
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502820707 261 LKSGWYSAIPWIvGTITEIVIGGWLVDRLinkgynrtRVSKFFLVIGMVFGLSIIGAAFTHSANVAVFWISTALGGLVVT 340
Cdd:cd06173 244 AGYGLLLAAFGV-GALLGALLLGRLSKRR--------RRGRLLLIGALLLGLALLVLGLSPSLWLLLAALFLLGLAGGLF 314
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 502820707 341 SAVAYSIPTFIAPKGTVGTLTGLLTFGNNSMAIVAPITTGFIVQATGSFMYAFLLAAAFLVIGILSYTF 409
Cdd:cd06173 315 NVPLNTLLQLRVPDELRGRVFSVYNALNSGAMPLGALLAGLLADALGLSAVFLLAGALLLLAALLLLLL 383
|
|
| MFS_MucK |
cd17371 |
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; ... |
10-411 |
4.97e-13 |
|
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Acinetobacter sp. Cis,cis-muconate transport protein (MucK), Escherichia coli putative sialic acid transporter 1, and similar proteins. MucK functions in the uptake of muconate and allows Acinetobacter calcoaceticus ADP1 (BD413) to grow on exogenous cis,cis-muconate as the sole carbon source. The MucK subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340929 [Multi-domain] Cd Length: 389 Bit Score: 70.02 E-value: 4.97e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502820707 10 FLIAVGVVVNYFDRINMSIAMPLLQKEFNLTAGQMGIFLSAFAWSYALLQLPIGPLLDKIGvkwvtRVATVIWTV----- 84
Cdd:cd17371 2 WAAFLGWALDGFDLLLLGLVLPALIAEFGLDEAEAGLLGTVTLAGGAIGGILGGILADRFG-----RVRVLVITIllfav 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502820707 85 ACLLTAVANGWGLIILSRVLLGVGEAPFFPSAAKAVSHWVPRQERGKAIAAYDSQSK----LSNAIGAPILALIVTEWGW 160
Cdd:cd17371 77 FTLLCGFAQNYWQLLILRALAGLGFGGEWAAGAALMAEYVPARHRGKALGYVQSGWAvgwlLATLLAALLFPLLPPEIAW 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502820707 161 RGGFLATAILSFIyaivywIWYREPHEDERLTKEEYDYIVQGGSQSSEEAKGSAMENIRYLLtkrkVWAVFIGFAAYGYs 240
Cdd:cd17371 157 RVLFLLGALPALL------VLFIRRFVKEPPQWQAARAARRHFADRPSLRELFSPPLLRTTL----LASLLATGALGGY- 225
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502820707 241 WFLfLTWLPGYLATEMNMSILKSGWYSAIpWIVGTITEIVIGGWLVDRLinkgyNRTRVSKFFLVIGMVFGLSIIgaaFT 320
Cdd:cd17371 226 YGI-TTWLPSYLTGERGLSFEGSAGYLVV-TILGGFLGYLAGGFLADRI-----GRRNNFALFALGSAISILLYF---FL 295
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502820707 321 HSANVAVFWISTALG-GLVVTSAVAYSIPTFIAPKGTVGTLTGLLTFGNNSMAIVAPITTGFIVQAtGSFMYAFLLAAAF 399
Cdd:cd17371 296 PLSPTLILILGFPLGfFASGPFSGMGAYLTELFPTAVRATAQGFCYNVGRIIGALFPFLVGFLATS-GSLGTAIAVFAAV 374
|
410
....*....|..
gi 502820707 400 LVIGILSYTFLL 411
Cdd:cd17371 375 YYIAGLVLALLL 386
|
|
| MFS_YjiJ |
cd06180 |
Uncharacterized protein YjiJ and similar proteins of the Major Facilitator Superfamily of ... |
30-405 |
7.31e-13 |
|
Uncharacterized protein YjiJ and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Escherichia coli YjiJ and other uncharacterized proteins. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340869 [Multi-domain] Cd Length: 371 Bit Score: 69.64 E-value: 7.31e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502820707 30 MPLLQKEFNLTAGQMGIFLSAFAWSYALLQLPIGPLLDKIGVKWVTRVATVIWTVACLLTAVANGWGLIILSRVLLGVGE 109
Cdd:cd06180 22 LPLMLAELGLSYAQAGWIATANYAGYLVGALLASFLRRRGRARRLIRGGLLLTVLLLAAMALTSGFAALLALRFLAGAAS 101
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502820707 110 APFFPSAAKAVSHWVPRQERGKAIAAYDSQSKLSNAIGAPILALIVTE-WGWRGGFLATAILSFIYAIVYWIWYREPHED 188
Cdd:cd06180 102 AFVFVFGSNLVLHHATAAGRGHLIGLLFAGVGLGIALSGLLVPAGLGGgLSWRAGWLALALLSAVLLLLSFLLLRRGPSA 181
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502820707 189 erltkeeydyivQGGSQSSEEAKGsameniryllTKRKVWAVFIGFAAYGYSWFLFLTWLPGYLATEMNmsilkSGWYSA 268
Cdd:cd06180 182 ------------PTEASAAESAPG----------LNRPLWRLALAYGLFGFGYIITATFLPLIARETGA-----GSLLAG 234
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502820707 269 IPWIVGTITeIVIGGWLVDRLINKGYNRTrvskFFLVIGMVFGLSIIGAAFTHSanVAVFWISTALGGLVVTSAVAYSIP 348
Cdd:cd06180 235 LLWSLFGLA-AVPSCFLWGALSDRWGTRR----ALAANLLVQAVGVLLPLLSPG--PAGLVLSAVLFGGTFMAITALVMA 307
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*....
gi 502820707 349 --TFIAPKGTVGTLtGLLTFGNNSMAIVAPITTGFIVQATGSFMYAFLLAAAFLVIGIL 405
Cdd:cd06180 308 laRELAPPAAPRAL-ALMTASFGVGQILGPLLAGWLADATGGFAPALILAAAALVVAAL 365
|
|
| MFS_NRT2_like |
cd17341 |
Plant Nitrate transporter NRT2 family and Bacterial Nitrate/Nitrite transporters of the Major ... |
27-409 |
1.01e-11 |
|
Plant Nitrate transporter NRT2 family and Bacterial Nitrate/Nitrite transporters of the Major Facilitator Superfamily; This family is composed of plant NRT2 family high-affinity nitrate transporters as well as nitrate and nitrite transporters from bacteria including Bacillus subtilis nitrate transporter NasA and nitrite extrusion protein NarK, Staphylococcus aureus NarT, Synechococcus sp. nitrate permease NapA, Mycobacterium tuberculosis NarK2 and nitrite extrusion protein NarU. NRT2 family proteins are involved in the uptake of nitrate by plant roots from the soil through the high-affinity transport system (HATS). There are seven Arabidopsis thaliana NRT2 proteins, called AtNRT2:1 to AtNRT2:7. The NRT2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340899 [Multi-domain] Cd Length: 384 Bit Score: 66.12 E-value: 1.01e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502820707 27 SIAMPLLQKEFNLTAGQMGIFLSAFAWSYALLQLPIGPLLDKIGVKWVTRVATVIWTVACLLTAVA-NGWGLIILSRVLL 105
Cdd:cd17341 19 APLGPVIRDDLGLSTSQIGLLVAIPVLAGALLRLPYGFLCDRFGGRRVFIASLLLLLIPLLALALAvSSYWGLLVLGFLL 98
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502820707 106 GVGEAPFFPSAAKAvSHWVPRQERGKAIAAYDSQSKLSNAIGAPILALIVTEW-------GWRGGFLATAILSFIYAIVY 178
Cdd:cd17341 99 GFAGANFASGQPWA-SFWFPKEKIGGAAGGIAGAGNMGVAVSQLLAPLIAGAIvfdggfvGWRNAFFVPGILLAIAAVLV 177
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502820707 179 WIWYREPhederltkeeydyivqggsqssEEAKGSAMENIRYLLTKRKVWAVFIGFAAYGYSWFLFLT---WLPGYLATE 255
Cdd:cd17341 178 LLFGDDL----------------------PTGKASALEFLKVQLAVLKNYRTWILSLLYGVTFGSFVGfsnVLPTYFKTR 235
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502820707 256 MNMSILKSGWYSAIPWIVGTITEiVIGGWLVDRLinKGYNRTRVSKFFLVIGMVF-GLSIIGAAFTHSANVAVFWISTAL 334
Cdd:cd17341 236 FGLPLVTAGILAALFPLAGALAR-PAGGWLSDRF--GGRRRLWWLFIVMTIGAALlSLSLPTSGTNLVLFLALFVALGLG 312
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 502820707 335 GGLVvtSAVAYSIPTFIAPKGTvGTLTGLLTFGNNSMAIVAPITTGFIVQATGSFMYAFLLAAAFLVIGILSYTF 409
Cdd:cd17341 313 AGAG--NGSVFRMVPFIFRREL-GAVTGLVGAIGGLGGFFLPLLFGSSALMTGSGVGAFSLFGVLAVACTLLVWL 384
|
|
| MFS_UhpC |
cd17488 |
Membrane sensor protein UhpC of the Major Facilitator Superfamily of transporters; Membrane ... |
5-177 |
3.60e-11 |
|
Membrane sensor protein UhpC of the Major Facilitator Superfamily of transporters; Membrane sensor protein UhpC acts as both a sensor and a transport protein. It is part of the UhpABC signaling cascade that controls the expression of the hexose phosphate transporter UhpT. UhpC recognizes external glucose-6-phosphate (Glc6P) and induces transport by UhpT. It can also transport and sense Glc6P, and interacts with the histidine kinase UhpB, leading to the stimulation of the autokinase activity of UhpB. This group also includes the hexose phosphate transport protein UhpT from Chlamydia pneumoniae; it is a transport protein for sugar phosphate uptake. It is part of the Organophosphate:Pi antiporter (OPA) family of integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The UhpC group belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341041 [Multi-domain] Cd Length: 364 Bit Score: 64.35 E-value: 3.60e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502820707 5 RWSIVFLIAVGVVVNYFDRINMSIAMPLLQKEFNLTAGQMGIFLSAFAWSYALLQLPIGPLLDKIGVKWVTRVATVIWTV 84
Cdd:cd17488 1 RIHILASMFIGYAVFYLTRKSFNAAMPAMLADLGLDKSDIGILGSLFYITYGVSKFVSGLMSDRSNPRYFMGIGLIATGI 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502820707 85 ACLLTAVANGWGLIILSRVLLGVGEAPFFPSAAKAVSHWVPRQERGKAIAAYDSQSKLSNAIGAPILALIVTEWGWRGGF 164
Cdd:cd17488 81 INILFGFSSSLWAFAVLWTLNAFFQGWGWPPCARLLTHWYSRNERGFWWSIWNTSHNIGGALIPILTGFAALTYGWRAGM 160
|
170
....*....|...
gi 502820707 165 LATAILSFIYAIV 177
Cdd:cd17488 161 YVPGIIAILMGIV 173
|
|
| MFS_MefA_like |
cd06173 |
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ... |
3-180 |
9.75e-11 |
|
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340863 [Multi-domain] Cd Length: 383 Bit Score: 63.02 E-value: 9.75e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502820707 3 KHRWSIVFLIAVGVVVNYFDRINMSIAMPLLQKEFNLTAGQMGIFLSAFAWSYALLQLPIGPLLDKIGVKWVTRVATVIW 82
Cdd:cd06173 205 RRSPLLRLLLLALALFALLGGALTVLLPLLAKEVLGGGAAGYGLLLAAFGVGALLGALLLGRLSKRRRRGRLLLIGALLL 284
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502820707 83 TVACLLTAVANGWGLIILSRVLLGVGEAPFFPSAAKAVSHWVPRQERGKAIAAYDSQSKLSNAIGAPILALIVTEWGWRG 162
Cdd:cd06173 285 GLALLVLGLSPSLWLLLAALFLLGLAGGLFNVPLNTLLQLRVPDELRGRVFSVYNALNSGAMPLGALLAGLLADALGLSA 364
|
170
....*....|....*...
gi 502820707 163 GFLATAILSFIYAIVYWI 180
Cdd:cd06173 365 VFLLAGALLLLAALLLLL 382
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
1-413 |
1.27e-10 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 63.00 E-value: 1.27e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502820707 1 MKKHRWSIVFLIAVGVVVNYFDRINMSIAMPLLQKEFNLTAGQMGIFLSAFAWSYALLQLPIGPLLDKIGVKWVTR---- 76
Cdd:COG2211 5 KKLSLKEKLAYGLGDLGLNLAFGLLSAYLLYFYTDVLGLSAALVGLILLVARLWDAITDPLIGALSDRTRTRWGRRrpwi 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502820707 77 -VATVIWTVACLLTAVANGWG----------LIILSRVLLGVGEAPFFPSAAKAVShwvPRQERGKAIAAYDSQSKLSNA 145
Cdd:COG2211 85 lIGAIPLALSFVLLFTAPDLSptgkliyalvTYLLLGLAYTLVNIPYSALGAELTP---DYEERTRLSSWRFAFAGLGGL 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502820707 146 IGAPILALIVTEWG---WRGGFLATAILSFIYAIVYWIWYRephederLTKEEYdyivqggsqSSEEAKGSAMENIRYLL 222
Cdd:COG2211 162 LASVLPPPLVAAFGgdaALGYRLTALIFAVLGLLAFLLTFF-------GTKERP---------VPEEEKVSLKESLKALL 225
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502820707 223 TKRKVWAVFIGFAAYGYSWFLFLTWLPGYLATEMNMSILKSGWYSAIpWIVGTITEIVIGGWLVDRLINKgynrtrvsKF 302
Cdd:COG2211 226 KNRPFLLLLLAYLLFFLALALVAALLLYYFKYVLGLSAALVGLLLAL-YFLAALLGAPLWPRLAKRFGKK--------KA 296
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502820707 303 FLVIGMVFGLSIIGAAFTHSANVAVFWISTALGGL--VVTSAVAYSIPTFIAPKGTV-------GTLTGLLTFGNNSMAI 373
Cdd:COG2211 297 FIIGLLLAALGLLLLFFLGPGNLWLLLVLAALAGIglGAILVLPWAMLADVVDYDEWktgrrreGLYFGIFTFAIKLGQA 376
|
410 420 430 440 450
....*....|....*....|....*....|....*....|....*....|....*
gi 502820707 374 VAPITTGFIVQATG---------------SFMYAFLLAAAFLVIGILSYTFLLTD 413
Cdd:COG2211 377 LAGALAGLLLALFGyvagaaqspsaltgiRLLFFLLPAVLLLLAALLLLFYPLTR 431
|
|
| MFS_Set |
cd17471 |
Sugar efflux transporter (Set) family of the Major Facilitator Superfamily of transporters; ... |
24-405 |
1.76e-10 |
|
Sugar efflux transporter (Set) family of the Major Facilitator Superfamily of transporters; This family is composed of sugar transporters such as Escherichia coli Sugar efflux transporter SetA, SetB, SetC and other sugar transporters. SetA, SetB, and SetC are involved in the efflux of sugars such as lactose, glucose, IPTG, and substituted glucosides or galactosides. They may be involved in the detoxification of non-metabolizable sugar analogs. The Set family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341024 [Multi-domain] Cd Length: 371 Bit Score: 62.18 E-value: 1.76e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502820707 24 INMSIAMPLLQ----KEFNLTAGQMGIFLSAFAWSYALLQLPIGPLLDKIGV-KWVTRVATVIWTVACLLTA-VANGWGL 97
Cdd:cd17471 10 LAGAFVLPYLSlfltEELGASPLQIGIFMTLSALSGIVVSQWLGRLSDRGGDrKPLILLALLAGALGYLLFAfLRNYWVL 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502820707 98 IILSRVLLGVGeAPFFP---SAAKAVSHWVPRQERGKAIAAYDSQSKLSNAIGAPILALIVTEWGWRGGFLATAILSFIY 174
Cdd:cd17471 90 LLVGVVLLSLG-AAAFPqlfALAREYADRSSGRDATLFNSVLRAAFSLAWVIGPPLAFLLLDVLGFTGLFLLAALLYLVV 168
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502820707 175 AIVYWIWYREPHederltkeeydyivqggSQSSEEAKGSAMENIRyllTKRKVWAVFIGFAAYGYSWFLFLTWLPGYLAT 254
Cdd:cd17471 169 ALLVLFLLPSVK-----------------PPAQKATPASSLVKAP---VNRRLLLLFAAFTLLFAANSMYIIAMPLYVTN 228
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502820707 255 EMNMSILKSGwysaipWIVGT--ITEIVI---GGWLVDRlinkgYNRTRVSKFFLVIGMVFGLSIIGAafTHSANVAVFW 329
Cdd:cd17471 229 ELGGSESWVG------LLFGLaaALEIPImllAGLLAKR-----FGKRRLLLAGFLAGVLFYLGLALA--TSLWQLIALQ 295
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 502820707 330 ISTALgGLVVTSAVAYSIPTFIAPkGTVGTLTGLLTFGNNSMAIVAPITTGFIVQATGsFMYAFLLAAAFLVIGIL 405
Cdd:cd17471 296 LLNAI-FIGITAGLGISYFQDLMP-GQPGLATTLYSNASRIGSLLGGLLAGVIAQYFG-YRAVFLVCAVLALLALV 368
|
|
| MFS_YcaD_like |
cd17477 |
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of ... |
30-405 |
3.03e-10 |
|
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MFS-type transporter YcaD, Bacillus subtilis MFS-type transporter YfkF, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341030 [Multi-domain] Cd Length: 360 Bit Score: 61.42 E-value: 3.03e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502820707 30 MPLLQKEFNLTAGQMGIFLSAFAWSYALLQLPIGPLLDKIGVKWVTRVATVIWTVACLLTAVANGWGLIILSRVLLGVGE 109
Cdd:cd17477 19 LSLRLEREGVSTALIGLVASAYYLGILLGSPLVPRLIRRVGHIRAFAAGAAITAVSVLLLALTDSPWVWFLLRFVMGIGL 98
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502820707 110 APFFPSAAKAVSHWVPRQERGKAIAAYDSQSKLSNAIGAPILALIVTEwGWRGGFLATAILSFIYAIVYWIWYREPHEDE 189
Cdd:cd17477 99 AGLFVVSESWLNALATNENRGRVLGLYSTVLGLGFALGPLLLALVGTA-GALPFLIAAVLLLLALVPLLLTRRAAPEIEE 177
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502820707 190 RltkeeydyivqggsqsseeakgsamENIRYLLTKRKVWAVFIGFAAYGYSWFLFLTWLPGYlATEMNMSILKSGWYSAI 269
Cdd:cd17477 178 A-------------------------ESISLRRLLRIAPLALLGAFVAGFLEGAFYSLLPLY-GLRLGLSVAQAALLLAA 231
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502820707 270 PWIVGTITEIVIgGWLVDRlinkgYNRTRVSKFFLVIGMVFGLSIIGAAFTHSANVAVFWISTALGGLVVTSAVAYSipT 349
Cdd:cd17477 232 FVLGGLLLQWPL-GWLADR-----FDRRRVLLGCALLGALAALLLPLVPGLPLALLVLLFLWGGAAGPLYTLALALA--G 303
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*.
gi 502820707 350 FIAPKGTVGTLTGLLTFGNNSMAIVAPITTGFIVQATGSFMYAFLLAAAFLVIGIL 405
Cdd:cd17477 304 DRLPGDELVAANAALLLLYGLGSVIGPLLAGALMDAFGPHGLFLFLAAVALLFLLF 359
|
|
| MFS_Tpo1_MDR_like |
cd17323 |
Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of ... |
9-411 |
3.45e-10 |
|
Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of fungal multidrug resistance (MDR) transporters including several proteins from Saccharomyces cerevisiae such as polyamine transporters 1-4 (Tpo1-4), quinidine resistance proteins 1-3 (Qdr1-3), dityrosine transporter 1 (Dtr1), fluconazole resistance protein 1 (Flr1), and protein HOL1. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, Flr1 confers resistance to the azole derivative fluconazole while Tpo1 confers resistance and adaptation to quinidine and ketoconazole. The polyamine transporters are involved in the detoxification of excess polyamines in the cytoplasm. Tpo1-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340881 [Multi-domain] Cd Length: 376 Bit Score: 61.44 E-value: 3.45e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502820707 9 VFLIAVGVVVNYFDRINMSIAMPLLQKEFNLTAGQMGIFLSAFAWSYALLQLPIGPLLDKIGVKWVTRVATVIWTVACLL 88
Cdd:cd17323 1 VFIISFLTFVVTFGSSIYSPALPQIAEDFHVSEEVANLGVSLFVLGFGLGPLIWAPLSELYGRRPVYLVSLFIFVIFQIG 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502820707 89 TAVANGWGLIILSRVLLGVGEAPFFPSAAKAVSHWVPRQERGKAIAAYDSQSKLSNAIGAPILALIVTEWGWRGGFLATA 168
Cdd:cd17323 81 CALAPNIAMLIILRFLQGFFGSSPLAIGAGTIADLFTPEERGKAMGVYSLGPLLGPALGPIIGGFITQSLGWRWIFWFLA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502820707 169 ILSFIYAIVywiwyrephederltkeeydyivqggsqsseeakgsamenirYLLTKRKVWaVFIGFAAYGYS-WFLFLTW 247
Cdd:cd17323 161 IISGFCLIL------------------------------------------IFLFLPIVL-LLGLYVGLVYAiLYLFLTA 197
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502820707 248 LPGYLATEMNMSILKSGwYSAIPWIVGTITEIVIGGWLVD----RLINKGYNRTRVSKFFLVIGMVFGLSIIGA-AFTHS 322
Cdd:cd17323 198 FPYVFGEVYGFSPGEVG-LMYLPIGIGALIGSIIGGRLSDyyyrRLKKKNGGKPEPEARLPPAFIGAFLFPIGLfIFGWT 276
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502820707 323 ANVAVFWISTALGGLVV--------TSAVAYSIPTFiapKGTVGTLTGLLTFGNNSMAIVAPITTGFIVQATGSFMYAFL 394
Cdd:cd17323 277 IYPHIHWIVPIIGSAFFgfglmlifQSSLTYLVDSY---PKYAASALAANTLVRSIFAAIFPLFAQPMFNNLGVGWAFTL 353
|
410
....*....|....*..
gi 502820707 395 LAAAFLVIGILSYTFLL 411
Cdd:cd17323 354 LAFISLAMIPIPFIFYK 370
|
|
| MFS_SLC37A4 |
cd17343 |
Solute carrier family 37 member 4 of the Major Facilitator Superfamily of transporters; Solute ... |
5-411 |
2.15e-09 |
|
Solute carrier family 37 member 4 of the Major Facilitator Superfamily of transporters; Solute carrier family 37 member 4 (SLC37A4), one of four SLC37 family proteins in vertebrates, is better known as glucose-6-phosphate transporter (G6PT). It is also called sugar phosphate exchanger 4 (SPX4), G6P translocase, or transformation-related gene 19 protein (TRG-19). G6PT is a phosphate (Pi)-linked G6P antiporter, catalyzing G6P:Pi and Pi:Pi exchanges. Deficiencies in human G6PT lead to glycogen storage disease type Ib (GSD-Ib), which is a metabolic and immune disorder. G6PT is a member of the Organophosphate:Pi antiporter (OPA)/SLC37 family, whose members are integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The OPA/SLC37 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340901 [Multi-domain] Cd Length: 409 Bit Score: 58.89 E-value: 2.15e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502820707 5 RWSIVFLIAVGVVVNYFDRINMSIAMPLLQKEFNLTAGQMGIFLSAFAWSYALLQLPIGPLLDKIGVKWVTRVATVI-WT 83
Cdd:cd17343 1 QLTIFASMFVGYTLYYFNRKSFSFVLPSLMNELGLDKSDLGLITSSQSLAYAISKFIGGVLSDQISARWLFSSGLVLsGL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502820707 84 VACLLTAVANGWGLIILsRVLLGVGEAPFFPSAAKAVSHWVPRQERGKAIAAYDSQSKLSNAIGAPILALIVTEWGWRGG 163
Cdd:cd17343 81 TTVAFSGSSSVWVFSIL-WFLNGLAQGLGWPPCAKILRKWFSPSQFGTWWSVLSTSMNLAGSLGPILATLLALSYGWRST 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502820707 164 FLATAILSFIYAIVYWIWYREPHEDERLTKEEYDYiVQGGSQSSEEAKGSAMEniryLLTKRKVWAVFIGFAAYGYSWFL 243
Cdd:cd17343 160 LSISGTVAVVMSVVCLLFIKNEPSDVGLNNIEEEE-SKGKKKKSPRGESTLKE----LLLSPFLWLLSLGYLVVFGVKTA 234
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502820707 244 FLTWLPGYLATEMNMS-ILKSGWYSAIPwiVGTITEIVIGGWLVDRLINKGYNRTRVS-KFFLVIGMVFGLSIIGAAFTH 321
Cdd:cd17343 235 VTDWGQLFLIQDKGQSaLTGSSFMSSLE--VGGFVGSIAAGYLSDWAVAKHGSSSRGNpRMPLALVFMAGLTVSLHLFRV 312
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502820707 322 --SANVAVFWIST--ALGGLVVTSAVAYS--IPTFIAPKGTVGTLTGLLTFGNNSMAIVAPITTGFIVQATGsFMYAFLL 395
Cdd:cd17343 313 hiTSDSSELFILLlgFLIGFSLYGPIAIFgvIANESAPSHLCGTSHAIVALAANVGGVLAGLPFSYIAKHYD-WRTAFLL 391
|
410
....*....|....*.
gi 502820707 396 aAAFLVIGILSYTFLL 411
Cdd:cd17343 392 -LEILCAITVVILFLL 406
|
|
| MFS_LmrB_MDR_like |
cd17503 |
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) ... |
26-410 |
2.17e-09 |
|
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including Bacillus subtilis lincomycin resistance protein LmrB, and several proteins from Escherichia coli such as the putative MDR transporters EmrB, MdtD, and YieQ. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341046 [Multi-domain] Cd Length: 380 Bit Score: 58.74 E-value: 2.17e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502820707 26 MSIAMPLLQKEFNLTAGQMGIFLSAFAWSYALLQLPIGPLLDKIGVKWVTRVATVIWTVACLLTAVANGWGLIILSRVLL 105
Cdd:cd17503 15 VNVALPTIMGDLGASLDTVQWVITSYLLALAIMIPLSGWLADRFGTRRLFLTALALFTLGSLLCGLAPNLASLIIFRILQ 94
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502820707 106 GVGEAPFFPSAAKAVSHWVPRQERGKAIAAYDSQSKLSNAIGAPILALIVTEWGWRGGF---LATAILSFIYAivywiwy 182
Cdd:cd17503 95 GFGGGVLIPLAQTILLRIYPPEKRGAAMGLVGLVILLAPAIGPTLGGWLTDNLSWRWIFyinLPIGILALLLA------- 167
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502820707 183 rephederltkeeydyivqggsqsseeakgsAMENIRYLLTKRKVWAVFIGFAAY-GYSWFLFLtwLPGYLATEMNMSIL 261
Cdd:cd17503 168 -------------------------------PLLDLRLFKDRNFTLGLLLSFLLGlGLFGAMFL--LPLYLQNVLGYSAF 214
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502820707 262 KSGWySAIPWIVGTITEIVIGGWLVDRLinkGYnrtrvsKFFLVIGM-VFGLS-IIGAAFTHSANVAVFWISTALGGL-- 337
Cdd:cd17503 215 ESGL-VLAPGGLASAILSPLVGRLLDKF---GP------RLLLLAGLlLLALGtLLLAFLTPDTSLWLIILPLFIRGLgm 284
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502820707 338 ------VVTSAVAySIPTFIAPKGT------------VGT--LTGLLT-FGNNSMAIVAPITTGFIVQATGS--FMYAFL 394
Cdd:cd17503 285 glvfmpLNTLALN-SLPPEQIGDATalfntirqlggsIGTalLATLLTnRTQFHHSRLSELLAQQVQKQALIiaFNDAFL 363
|
410
....*....|....*.
gi 502820707 395 LAAAFLVIGILSYTFL 410
Cdd:cd17503 364 VSAILLLVGLLLALFL 379
|
|
| glpT |
PRK11273 |
glycerol-3-phosphate transporter; |
2-410 |
2.71e-09 |
|
glycerol-3-phosphate transporter;
Pssm-ID: 236889 [Multi-domain] Cd Length: 452 Bit Score: 58.95 E-value: 2.71e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502820707 2 KKHRWSIVFLIAVGVVVNYFDRINMSIAMPLLQKEfNLTAGQMGIFLSAFAWSYALLQ---------------LPIGPLL 66
Cdd:PRK11273 24 RRLRWQIFLGIFFGYAAYYLVRKNFALAMPYLVEQ-GFSRGDLGFALSGISIAYGFSKfimgsvsdrsnprvfLPAGLIL 102
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502820707 67 DKI------GVKWVTRVATVIWTVACLltavaNGWgliilsrvLLGVGeapfFPSAAKAVSHWVPRQERGKAIAAYDSQS 140
Cdd:PRK11273 103 AAAvmlfmgFVPWATSSIAVMFVLLFL-----CGW--------FQGMG----WPPCGRTMVHWWSQKERGGIVSVWNCAH 165
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502820707 141 KLSNAIgAPILALIVTEW--GWRGGFLATAILSFIYAIVYWIWYREPHEDERLTK-EEYDYIVQGGSQSSEEAKGSAME- 216
Cdd:PRK11273 166 NVGGGL-PPLLFLLGMAWfnDWHAALYMPAFAAILVALFAFAMMRDTPQSCGLPPiEEYKNDYPDDYNEKHEQELTAKQi 244
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502820707 217 NIRYLLTKRKVWA-----VFIGFAAYGyswflFLTWLPGYLATEMNMSILKSGW------YSAIPwivGTIteivIGGWL 285
Cdd:PRK11273 245 FMQYVLPNKLLWYiaianVFVYLLRYG-----ILDWSPTYLKEVKHFALDKSSWayflyeYAGIP---GTL----LCGWM 312
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502820707 286 VDRLInKGyNRTRVSKFFLVIGMVfglsiigaafthsaNVAVFWISTA------LGGLVVTSAVAYSIPTFI-------A 352
Cdd:PRK11273 313 SDKVF-RG-NRGATGVFFMTLVTI--------------ATIVYWLNPAgnptvdMACMIVIGFLIYGPVMLIglhalelA 376
|
410 420 430 440 450 460
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 502820707 353 PK---GTVGTLTGLltFGNNSMAIVAPITTGFIVQA---TGSFMyaFLLAAAFLVIGILSYTFL 410
Cdd:PRK11273 377 PKkaaGTAAGFTGL--FGYLGGSVAASAIVGYTVDFfgwDGGFM--VMIGGSILAVILLIVVMI 436
|
|
| MFS_TRI12_like |
cd06179 |
Fungal trichothecene efflux pump (TRI12) of the Major Facilitator Superfamily of transporters; ... |
49-365 |
3.57e-09 |
|
Fungal trichothecene efflux pump (TRI12) of the Major Facilitator Superfamily of transporters; This family includes Fusarium sporotrichioides trichothecene efflux pump (TRI12), which may play a role in F. sporotrichioides self-protection against trichothecenes. TRI12 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340868 [Multi-domain] Cd Length: 518 Bit Score: 58.79 E-value: 3.57e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502820707 49 SAFAWSYALLQLPIGPLLDKIGVKWVTRVATVIWTVACLLTAVANGWGLIILSRVLLGVGEAPFFPSAAkAVSHWVPRQE 128
Cdd:cd06179 39 TAWSLAQAVLGPIVGRLSDLFGRRWFFIGGNLLGVVGSIVAGTAKSVNMLIGGQALIGIGAGTQGLGAA-VASELVPNKY 117
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502820707 129 RGKAIAAYDSQSKLSNAIGAPILALIVTEW--GWRGGFLATAILSFIYAIVYWIWYREPH---EDERLTKE---EYDYI- 199
Cdd:cd06179 118 RGLVQGVVNLVASPGSALGPLIAGALVEANaaGWRWIFYINAIFNALALILLFFFYHPPPrpqLHGSSTRQklkRLDWVg 197
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502820707 200 ---------------VQGGSQ---SSE-------------------EAKGS--AMENIRYLLTKRKVWAVFIGFAAYGYS 240
Cdd:cd06179 198 lflliaglvlfllglSWGGNPypwSSAhviaplviggvlliafglyEWKGTkdGLLPPRLLFRGRNFALILIVAFVEGMI 277
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502820707 241 WFLFLTWLPGYLATEMNMSILKSGWYSaIPWIVGTITEIVIGGWLVDrlinkgynRTRVSKFFLVIG-MVFGLSIIGAAF 319
Cdd:cd06179 278 FYSLNIFWPQQISLLFTTDPLKAGLYQ-LPFGLGTLFGAILAGLLLT--------KIKHIKWQLVAGfVLFTAFLALLAL 348
|
330 340 350 360
....*....|....*....|....*....|....*....|....*...
gi 502820707 320 THSANVAVFWISTALGGLVV--TSAVAYSIPTFIAPKGTVGTLTGLLT 365
Cdd:cd06179 349 ITPDNKALAIAFSVLAGIGIggPLVLAIVIVQLSVPPEDIGTASGLLG 396
|
|
| MFS_FucP_MFSD4_like |
cd17333 |
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein ... |
26-409 |
4.08e-09 |
|
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4, and similar proteins; This family is composed of bacterial L-fucose permease (FucP), eukaryotic Major facilitator superfamily domain-containing protein 4 (MFSD4) proteins, and similar proteins. L-fucose permease facilitates the uptake of L-fucose across the boundary membrane with the concomitant transport of protons into the cell; it can also transport L-galactose and D-arabinose. The MFSD4 subfamily consists of two vertebrate members: MFSD4A and MFSD4B. The function of MFSD4A is unknown. MFSD4B is more commonly know as Sodium-dependent glucose transporter 1 (NaGLT1), a primary fructose transporter in rat renal brush-border membranes that also facilitates sodium-independent urea uptake. The FucP/MFSD4 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340891 [Multi-domain] Cd Length: 372 Bit Score: 58.10 E-value: 4.08e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502820707 26 MSIAMPLLQKEFNLTAGQMGIFLSAFAWSYALLQLPIGPLLDKIGVKWVTRVATVIWTVACLLTAVANGWGLIILSRVLL 105
Cdd:cd17333 15 LGILGPSLEEAFNLNVADVSVIFSSQNAGYLIGSLLAGFLMKRLGRRRTLILGLLLISLALALIFATPSIYLFVVLMFLA 94
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502820707 106 GVGEAPFFPSA-AKAVSHWVPRQER--GKAIAAYDSQSKLSNAIGAPILAlIVTEWGWrgGFLATAILSFIYAIVYWIWY 182
Cdd:cd17333 95 GLGAGILDTGAnTFVGALFEESSATrlNVLHGFFGLGALIGPLIATSLLT-SELSWSW--AYLIIGLIYLLLAILILLTL 171
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502820707 183 REPHEDerltkeeyDYIVQGGSQSSEEAKGSAMENirylltkRKVWAVFIGFAAYGYSWFLFLTWLPGYLATEMNMSILK 262
Cdd:cd17333 172 FPELPS--------ARNPQQSVGAFSASASRLLRN-------PSIILGALALFLYVGAETAFSSWVPSYLVEKKHVSDGL 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502820707 263 SGWYSAIPWIVGTITEIvIGGWLVDRLinkgynrtrVSKFFLVIGmVFGLSIIGAAFTHSANVAVFWISTALGGL----V 338
Cdd:cd17333 237 AGYLLSGFWVGITIGRL-LGGPISRRI---------KPHTLLVLS-GSGALLGLLILLLAPTLVVGLVATALLGLfmaaL 305
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 502820707 339 VTSAVAYSIPTFIAPKGTVgtlTGLLTFGNNSMAIVAPITTGFIVQATGSfMYAFLLAAAFLVIGILSYTF 409
Cdd:cd17333 306 FPTILSLGISNLPYAKGKG---TSVLLAAGSIGGAIIPFIMGFIAEAVGI-QTAMLLITILYAIIFVLALL 372
|
|
| MFS_YfmO_like |
cd17474 |
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ... |
32-181 |
6.56e-09 |
|
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341027 [Multi-domain] Cd Length: 374 Bit Score: 57.20 E-value: 6.56e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502820707 32 LLQKEFNLTAGQMGIFLSAFAWSYALLQLPIGPLLDK-IGVKWVTRVATVIWTVACLLTAVANGWGLIILSRVLLGVGEA 110
Cdd:cd17474 224 LLELLYGISPIIIGLLFAGWSVLLALGSLFVGRLLKKrFGARRILVIGLLLYALSLLLLGFVPSLALLLIAIVLFGLGLG 303
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 502820707 111 PFFPSAAKAVSHWVPRQERGKAIAAYDSQSKLSNAIGAPILALIVTEWGWRGGFLATAILSFIYAIVYWIW 181
Cdd:cd17474 304 LNLPLLTTLVTELAPEEERGTASSLYNFVRFLGQAVGPLLFGLLLEIFGLSAPFLVGAAIALAAAVLLALL 374
|
|
| MFS_MJ1317_like |
cd17370 |
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed ... |
8-179 |
1.98e-08 |
|
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed of Methanocaldococcus jannaschii MFS-type transporter MJ1317, Mycobacterium bovis protein Mb2288, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340928 [Multi-domain] Cd Length: 371 Bit Score: 56.01 E-value: 1.98e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502820707 8 IVFLIAVGvvvnyfdriNMSIAMPLLQ-KEFNLTAGQMGIFLSAFAWSYALLQLPIGPLLDKIGVKWVTRVATVIWTVAC 86
Cdd:cd17370 208 AVALFALG---------NFSFAFLILRaQELGLSAALIPLLYALFNLVYALAAYPAGRLSDRIGRKKLLILGYLSLALAY 278
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502820707 87 LLTAVANGWGLIILSRVLLGVGEAPFFPSAAKAVSHWVPRQERGKAIAAYDSQSKLSNAIGAPILALIVTEWGWRGGFLA 166
Cdd:cd17370 279 LGFALGSSLWLLLLGFILWGLYMGAQESIERAAVADLVPAELRGTAYGLFNTVVGIGWLLASLIAGYLWDLISPSAAFLF 358
|
170
....*....|...
gi 502820707 167 TAILSFIYAIVYW 179
Cdd:cd17370 359 SAVLALIALLLLL 371
|
|
| PRK03893 |
PRK03893 |
putative sialic acid transporter; Provisional |
6-176 |
2.72e-08 |
|
putative sialic acid transporter; Provisional
Pssm-ID: 179668 [Multi-domain] Cd Length: 496 Bit Score: 55.86 E-value: 2.72e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502820707 6 WSIVFLIAVGVVVNYFDRINMSIAMPLLQKEFNLTAGQMGIFLSAFAWSYALLQLPIGPLLDKIGVKWVTRVATVIWTVA 85
Cdd:PRK03893 19 WKAFSAAWLGYLLDGFDFVLITLVLTEVQGEFGLTTVQAASLISAAFISRWFGGLLLGAMGDRYGRRLAMVISIVLFSVG 98
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502820707 86 CLLTAVANGWGLIILSRVLLGVGEAPFFPSAAKAVSHWVPRQERGKAIAAYDSQSKLSNAIGAPILALIVTEWGWRGGFL 165
Cdd:PRK03893 99 TLACGFAPGYWTLFIARLVIGMGMAGEYGSSATYVIESWPKHLRNKASGFLISGFSIGAVVAAQVYSLVVPVWGWRALFF 178
|
170
....*....|.
gi 502820707 166 aTAILSFIYAI 176
Cdd:PRK03893 179 -IGILPIIFAL 188
|
|
| MFS_Amf1_MDR_like |
cd17476 |
Saccharomyces cerevisiae low affinity ammonium transporter Amf1p/YOR378W, aminotriazole ... |
25-183 |
3.08e-08 |
|
Saccharomyces cerevisiae low affinity ammonium transporter Amf1p/YOR378W, aminotriazole resistance protein Atr1p, and similar transporters of the Major Facilitator Superfamily; Saccharomyces cerevisiae Amf1p/Ammonium Facilitator 1/YOR378W functions as a low affinity NH4+ transporter. S. cerevisiae aminotriazole resistance protein (Atr1p) is required for controlling sensitivity to aminotriazole; it is a putative component of the machinery responsible for pumping aminotriazole (and possibly other toxic compounds) out of the cell. This subfamily also includes S. cerevisiae YMR279C, a putative boron transporter involved in boron efflux and resistance, and Kluyveromyces lactis Knq1p which is involved in oxidative stress response and iron homeostasis. Amf1p, Atr1p, and YMR279C have been classified as group 1 members of the DHA2 (Drug:H+ Antiporter family 2) family, K. lactis Knq1 as group 2. This subfamily also includes two Aspergillus terreus terrein biosynthesis cluster proteins, efflux pump TerG and TerJ which may be required for efficient secretion of terrein or other secondary metabolites produced by the terrein gene cluster. The Amf1p-like subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341029 [Multi-domain] Cd Length: 362 Bit Score: 55.35 E-value: 3.08e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502820707 25 NMSIAMPLLQKEFNLTAGQMGIFLSAFAWSYALLQLPIGPLLDKIGVKWVTRVATVIWTVACLLTAVANGWGLIILSRVL 104
Cdd:cd17476 16 SVIVILPIIGDSFGTSPNQLSWLAASYSLTVGTFILIFGRLGDIYGHKKMFVIGSFWFAIWSLIAGFSPNFIFFIICRAL 95
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502820707 105 LGVGEAPFFPSAAKAVSH-WVPRQERGKAIAAYDSQSKLSNAIGAPILALIVTEWGWRGGFLATAILSFIYAIVYWIWYR 183
Cdd:cd17476 96 QGLGPAFLLPNAMALLGRtYPPGPRKNIVFSLFGATAPLGFALGGVFGGLFAQLAWWPWIFWFLAILAAIVAVAAIFWTS 175
|
|
| MFS_OFA_like |
cd17353 |
Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of ... |
27-410 |
8.00e-08 |
|
Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of Oxalobacter formigenes oxalate:formate antiporter (OFA or OxlT) and similar proteins. O. formigenes, a commensal found in the gut of animals and humans, plays an important role in clearing dietary oxalate from the intestinal tract, which is carried out by OFA/OxlT, an anion transporter that facilitates the exchange of divalent oxalate with monovalent formate, the product of oxalate decarboxylation. This exchange generates an electrochemical proton gradient and is the source of energy for ATP synthesis in this cell. The OFA-like subfamily belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340911 [Multi-domain] Cd Length: 389 Bit Score: 54.15 E-value: 8.00e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502820707 27 SIAMPLLQKEFNLTAGQMGIFLSAFAWSYALLQLPIGPLLDKIGVKWVTRVATVIWTVACLLTAVA-NGWGLIILSRVLL 105
Cdd:cd17353 23 SVFNPPLSSALGWSLASVALAFTLTIVFLAISAPFAGRLVDRGGPRKAILIGGILFGLGFILSAFAiSLPLLFLGYGVLG 102
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502820707 106 GVGEAPFFPSAAKAVSHWVPrQERGKAIAAYDSQSKLSNAIGAPILALIVTEWGWRGGFLATAILSFIYAIVYWIWYREP 185
Cdd:cd17353 103 GIGAGIGYITPVSTAVKWFP-DKRGLATGIVIAGFGLGSLIFSPLIAYLINTVGVPTTFLILGIIFLIIIVIGAFLIRDP 181
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502820707 186 HEDErlTKEEYDYIVQGGSQSSEEAKGSAMENIR--YLLtkrkvWAVFIGFAAYGyswfLFLTWLPGYLATEMNMSILKS 263
Cdd:cd17353 182 PKGW--VPPGVDPLANNAENSPRDYTPREMLRTPtfWLL-----WLMFFLNATAG----LMLIGQAKPIGQEFAGLDAGI 250
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502820707 264 GWYSAIPWIVGTITEIVIGGWLVDRLinkgyNRTRVSKFFLVIGMVFGLSIIGAAFTHSANVAVFWISTALGGLVVTSAV 343
Cdd:cd17353 251 AALAVSILSIFNGGGRPFWGWLSDKI-----GRKNTLSIAFLIQGVAMFLLPFIGSVAVLFVLGVALIGFCYGGGFALFP 325
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 502820707 344 AYSIPTFiapkGT--VGTLTGLLTFGNNSMAIVAPITTGFiVQATGSFMYAFLLAAAFLVIGILSYTFL 410
Cdd:cd17353 326 ALTADFF----GTknAGTNYGLLYTAKGVGGLIGPIIAAY-VLYTGGYNAAFIIAAALSLVALALALLL 389
|
|
| MFS_MCT_SLC16 |
cd17352 |
Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily of transporters; ... |
33-410 |
9.90e-08 |
|
Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily of transporters; The animal Monocarboxylate transporter (MCT) family is also called Solute carrier family 16 (SLC16 or SLC16A). It is composed of 14 members, MCT1-14. MCTs play an integral role in cellular metabolism via lactate transport and have been implicated in metabolic synergy in tumors. MCT1-4 are proton-coupled transporters that facilitate the transport across the plasma membrane of monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and ketone bodies such as acetoacetate, beta-hydroxybutyrate and acetate. MCT8 and MCT10 are transporters which stimulate the cellular uptake of thyroid hormones such as thyroxine (T4), triiodothyronine (T3), reverse triiodothyronine (rT3) and diidothyronine (T2). MCT10 also functions as a sodium-independent transporter that mediates the uptake or efflux of aromatic acids. Many members are orphan transporters whose substrates are yet to be determined. The MCT family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340910 [Multi-domain] Cd Length: 361 Bit Score: 53.71 E-value: 9.90e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502820707 33 LQKEFNLTAGQMGIFLSAFAWSYALLQLPIGPLLDKIGVKWVTRVATVIWTVACLLTAVA-NGWGLIILSRVLLGVGEAP 111
Cdd:cd17352 29 LLEEFGESTSDIAWIGSLLLGVSLFSGPLSSALVNRFGCRPVAIAGGLLAALGLLLSSFAtSLWQLYLTYGVLGGLGLGL 108
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502820707 112 FFPSAAKAVSHWVPRQeRGKAIAAYDSQSKLSNAIGAPILALIVTEWGWRGGFLATAILSFIyAIVYWIWYRephederl 191
Cdd:cd17352 109 IYSPAIVIVGQYFEKK-RGLATGIAVAGSGVGTFVFPPLLRYLLDNYGWRGALLILGGLCLN-LCVCGLLLR-------- 178
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502820707 192 tkeeydyivqggsqsseeakgsameniryLLTKRKVWAVFIG--FAAYGYswFLFLTWLPGYlATEMNMSILKSGWYSAI 269
Cdd:cd17352 179 -----------------------------LLKDPTFVLLALGvsFAMLGF--FVPFVYLPSY-AKSLGIDESDAAFLLSI 226
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502820707 270 PWIVGTITEIVIGgWLVDRLINKGYNRtrvskfflvigMVFGLSIIGAAfthsanVAVFWISTALGGLVVTSAV------ 343
Cdd:cd17352 227 IGISDIVGRILLG-LLADKPRIGRLYL-----------YIFTLLILGLS------LLAFPLATTYVGLIVFSVLfgfcsg 288
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 502820707 344 AYSIPTFIAPKGTVGT--LT---GLLTFGNNSMAIVAPITTGFIVQATGSFMYAFLLAAAFLVIGILSYTFL 410
Cdd:cd17352 289 SYSSLTPVILADLVGLekLSnayGLVLLFQGLAALVGPPIAGLLRDYTGDYDAAFYFCGACLLLSGVLLFLL 360
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
6-187 |
1.29e-07 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 53.34 E-value: 1.29e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502820707 6 WSIVFLIAVGVVVNYFDRINMSIAMPLLQKEFNLTAGQMGIFLSAFAWSYALLQLPIGPLLDKIG--VKWVTRVATVIWT 83
Cdd:COG2271 180 LRFWLLALAYFLVYFALYGFLTWLPTYLVEVRGLSLAQAGLLLSLPFLAGIVGSLLGGWLSDRLGrrRKLVLAIGLLLAA 259
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502820707 84 VACLLTAVANGWGLIILSRVLLGVGEAPFFPSAAKAVSHWVPRQERGKAIAAYDSQSKLSNAIGAPILALIVTEWGWRGG 163
Cdd:COG2271 260 LALLLLALLPSPALAIALLFLAGFGLGGAFGLLWALAAELFPKKARGTASGLVNTFGFLGGALGPLLVGYLLDATGYQAA 339
|
170 180
....*....|....*....|....
gi 502820707 164 FLATAILSFIYAIVYWIWYREPHE 187
Cdd:COG2271 340 FLLLAALALLAALLALLLLRETRK 363
|
|
| MFS_SLC22A18 |
cd17331 |
Solute carrier family 22 member 18 of the Major Facilitator Superfamily of transporters; ... |
29-401 |
1.49e-07 |
|
Solute carrier family 22 member 18 of the Major Facilitator Superfamily of transporters; Solute carrier family 22 member 18 (SLC22A18) is also called Beckwith-Wiedemann syndrome chromosomal region 1 candidate gene A protein (BWR1A or BWSCR1A), efflux transporter-like protein, imprinted multi-membrane-spanning polyspecific transporter-related protein 1 (IMPT1), organic cation transporter-like protein 2 (ORCTL2), or tumor-suppressing subchromosomal transferable fragment candidate gene 5 protein (TSSC5). It is localized at the apical membrane surface of renal proximal tubules and may act as an organic cation/proton antiporter. It functions as a tumor suppressor in several cancer types including glioblastoma and colorectal cancer. SLC22A18 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340889 [Multi-domain] Cd Length: 382 Bit Score: 52.99 E-value: 1.49e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502820707 29 AMPLLQKEFNLTAGQMGIFLSAFAwsyaLLQL---PI-GPLLDKIGVKWVTRVATVIWTVACLLTAVANGWGLIILSRVL 104
Cdd:cd17331 22 VLPYLTKKLGVDSVVFGYLQTTFS----VLQLvggPLfGRFGDLFGPRAALVLSFLSSALSYLLLAFASSVPMLFLSRLP 97
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502820707 105 LGVGEApfFPSAAKAVSHWVPRQERGKAIAaydsqsKLSNA------IGAPILALIVTEWGWRGGFLATAILSFIYAIVY 178
Cdd:cd17331 98 SVFMHA--MQAAQMVVTDLTDPGERAAALG------RLGLSygigmvVGSFLGGLLTKKFGEQAAALVAAVGSLLSIVLV 169
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502820707 179 WIWYREPHEDERLTKEEydyivqggsQSSEEAKGSAMENIRYLLTKRKVWAVFIGFAAYGYSWFLFLTWLPGYLATEMNM 258
Cdd:cd17331 170 ILLIPSNTKSKREKEAK---------ESASPPSVFNLKEILRLLRLPGVAFLLLVKLLSGLPIGMFQSMFSLVAMDFFGL 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502820707 259 SILKSGWYSAIPWIVGTITEIVIGGWLvdrlinkgynRTRVSKFFLVIGMVFGLSIIGAAFTHSANVAVFWISTALggLV 338
Cdd:cd17331 241 TPEENGYLMSYAGVLGMVVQGLLVGPL----------TKRFGERSLLKLSVALLAIGYLLLAFVTTVWQLLVLLLP--LV 308
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 502820707 339 VTSAVAY----SIPTFIAPKGTVGTLTGLLTFGNNSMAIVAPITTGFIVQATGSFMYAFLLAAAFLV 401
Cdd:cd17331 309 IGGSVLYtvitSLLTKAVPPEDTGTALGLSHALFSLVRTVSPTIGGALLQAYGFPSFGLLGAAINGL 375
|
|
| PRK12307 |
PRK12307 |
MFS transporter; |
9-404 |
6.45e-07 |
|
MFS transporter;
Pssm-ID: 237051 [Multi-domain] Cd Length: 426 Bit Score: 51.47 E-value: 6.45e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502820707 9 VFLIAVGVVVNYFDRINMSIAMPLLQKEFNLTAGQmgiflSAFAWSYALLQLPIG-----PLLDKIGVKWVTRVATVIWT 83
Cdd:PRK12307 20 LFSAWLGYVFDGFDFMLIFYIMYLIKADLGLTDME-----GAFLATAAFIGRPFGgalfgLLADKFGRKPLMMWSIVAYS 94
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502820707 84 VACLLTAVANGWGLIILSRVLLGVGEAPFFPSAAK-AVSHWvPRQERGKAIAAYDSQSKLSNAIGAPILALIVTEWGWRG 162
Cdd:PRK12307 95 VGTGLSGLASGVIMLTLSRFIVGMGMAGEYACASTyAVESW-PKHLKSKASAFLVSGFGIGNIIAAYFMPSFAEAYGWRA 173
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502820707 163 GFLaTAILSFIyaIVYWIWYREPHederlTKEEYDYIVQGGSQSSEEAKGSAMENIRYLLTKRKV---WAVFI-GFAAYG 238
Cdd:PRK12307 174 AFF-VGLLPVL--LVIYIRARAPE-----SKEWEEAKLSGKGKHSQSAWSVFSLSMKGLFNRAQFpltLCVFIvLFSIFG 245
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502820707 239 YSWFLFlTWLPGYLATEMNMSILKSGWYSAIPwiVGTITEIVIGGWLVDRLinkGYNRTrvskffLVIGMVFGLSIIGAA 318
Cdd:PRK12307 246 ANWPIF-GLLPTYLAGEGFDTGVVSNLMTAAA--FGTVLGNIVWGLCADRI---GLKKT------FSIGLLMSFLFIFPL 313
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502820707 319 FTHSANVAVFwISTALGGLVVTS-AVAYSIPTFIA---PKGTVGTLTGLLTFGNNSMAIVAPITTGFIVQATG-----SF 389
Cdd:PRK12307 314 FRIPQDNYLL-LGACLFGLMATNvGVGGLVPKFLYdyfPLEVRGLGTGLIYNLAATSGTFNSMAATWLGITMGlgaalTF 392
|
410
....*....|....*
gi 502820707 390 MYAFLLAAAFLVIGI 404
Cdd:PRK12307 393 IVAFWTATILLIIGL 407
|
|
| nepI |
PRK10213 |
purine ribonucleoside efflux pump NepI; |
6-185 |
9.98e-07 |
|
purine ribonucleoside efflux pump NepI;
Pssm-ID: 182309 [Multi-domain] Cd Length: 394 Bit Score: 50.69 E-value: 9.98e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502820707 6 WSIVFLIAVGVV-VNYFDRINMSIAMPLLQkEFNLTAGQMGIFLSAFAWSYALLQLPIGPLLDKIGVKWVTRVATVIWTV 84
Cdd:PRK10213 19 WSAVFSVAFCVAcLIIVEFLPVSLLTPMAQ-DLGISEGVAGQSVTVTAFVAMFASLFITQTIQATDRRYVVILFAVLLTL 97
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502820707 85 ACLLTAVANGWGLIILSRVLLGVGEAPFFPSAAKAVSHWVPRQERGKAIAAYDSQSKLSNAIGAPILALIVTEWGWRGGF 164
Cdd:PRK10213 98 SCLLVSFANSFSLLLIGRACLGLALGGFWAMSASLTMRLVPPRTVPKALSVIFGAVSIALVIAAPLGSFLGELIGWRNVF 177
|
170 180
....*....|....*....|.
gi 502820707 165 LATAILSFIyaIVYWIWYREP 185
Cdd:PRK10213 178 NAAAVMGVL--CIFWIIKSLP 196
|
|
| MFS_YcaD_like |
cd17477 |
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of ... |
3-177 |
1.71e-06 |
|
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MFS-type transporter YcaD, Bacillus subtilis MFS-type transporter YfkF, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341030 [Multi-domain] Cd Length: 360 Bit Score: 49.86 E-value: 1.71e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502820707 3 KHRWSIVFLIAVGVVVNYFDRINMSIAMPLLQKEFNLTAGQMGIFLSAFAWSYALLQLPIGPLLDKIGVKWVTRVATVIW 82
Cdd:cd17477 184 RRLLRIAPLALLGAFVAGFLEGAFYSLLPLYGLRLGLSVAQAALLLAAFVLGGLLLQWPLGWLADRFDRRRVLLGCALLG 263
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502820707 83 TVACL-LTAVANGWGLIILSRVLLGVGEAPFFPSAAKAVSHWVPRQERGKAIAAYDSQSKLSNAIGAPILALIVTEWGWR 161
Cdd:cd17477 264 ALAALlLPLVPGLPLALLVLLFLWGGAAGPLYTLALALAGDRLPGDELVAANAALLLLYGLGSVIGPLLAGALMDAFGPH 343
|
170
....*....|....*.
gi 502820707 162 GGFLATAILSFIYAIV 177
Cdd:cd17477 344 GLFLFLAAVALLFLLF 359
|
|
| MFS_SLC46_TetA_like |
cd17330 |
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and ... |
6-177 |
1.75e-06 |
|
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of the eukaryotic proteins MFSD9, MFSD10, MFSD14, and SLC46 family proteins, as well as bacterial multidrug resistance (MDR) transporters such as tetracycline resistance protein TetA and multidrug resistance protein MdtG. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. TetA proteins confer resistance to tetracycline while MdtG confers resistance to fosfomycin and deoxycholate. The Solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3), the best-studied of which is SLC46A1, which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. MFSD10 facilitates the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs) and confers resistance to such NSAIDs. The SLC46/TetA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340888 [Multi-domain] Cd Length: 349 Bit Score: 49.50 E-value: 1.75e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502820707 6 WSIVFLIAVGVVVNYFDRINMSIAMPLLQKEFNLTAGQMGIFLSAFAWSYALLQLPIGPLLDK-IGVKWVTRVATVIWTV 84
Cdd:cd17330 174 PPLRRLLLVYFLIALAFAGLESVFSLFLKDRFGFSPSQIGLLLALVGIAGILAQLLLIPRLAKrLGERKLLRLGLLLAII 253
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502820707 85 ACLLTAVANGWGLIILSRVLLGVGEAPFFPSAAKAVSHWVPRQERGKAIAAYDSQSKLSNAIGAPILALIVTEWGWRGGF 164
Cdd:cd17330 254 GLLLLPFASSVPLLVLAAAILAFGTGIVFPALSALLSKSVPSKEQGKAQGIIQSLQSLARIIGPLLAGPLYSFLGPGVPF 333
|
170
....*....|...
gi 502820707 165 LATAILSFIYAIV 177
Cdd:cd17330 334 LLAAGLLLIALFL 346
|
|
| PRK12382 |
PRK12382 |
putative transporter; Provisional |
45-177 |
1.81e-06 |
|
putative transporter; Provisional
Pssm-ID: 183487 [Multi-domain] Cd Length: 392 Bit Score: 49.67 E-value: 1.81e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502820707 45 GIFLSAFAWSYALLQLPIGPLLDKIGVKWVTRVATVIWTVACLLTAVANGWGLIILSRVLLGVGEAPFFPSAAKAVSHWV 124
Cdd:PRK12382 252 GFTLTAFGGAFVLMRVLFGWMPDRFGGVKVAIVSLLVETVGLLLLWLAPTAWVALAGAALTGAGCSLIFPALGVEVVKRV 331
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|...
gi 502820707 125 PRQERGKAIAAYDSQSKLSNAIGAPILALIVTEWGWRGGFLATAILSFIYAIV 177
Cdd:PRK12382 332 PSQVRGTALGGYAAFQDIAYGVSGPLAGMLATSFGYPSVFLAGAISAVLGIIV 384
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
227-411 |
1.99e-06 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 49.59 E-value: 1.99e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502820707 227 VWAVFIGFAAYGYSWFLFLTWLPgYLATEMNMSILKSGWYSAIPWIVGTITeIVIGGWLVDRlinkgYNRTRVskfFLVI 306
Cdd:COG2814 12 LLALALGAFLSGLGIGIVLPALP-LIAADLGASPAQAGLVVTAYLLGAALG-APLAGRLADR-----FGRRRV---LLLG 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502820707 307 GMVFGLSIIGAAFTHSanVAVFWISTALGGL--VVTSAVAYSIPTFIAPKGTVGTLTGLLTFGNNSMAIVAPITTGFIVQ 384
Cdd:COG2814 82 LLLFALGSLLCALAPS--LWLLLAARFLQGLgaGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLAD 159
|
170 180
....*....|....*....|....*..
gi 502820707 385 ATGsFMYAFLLAAAFLVIGILSYTFLL 411
Cdd:COG2814 160 LFG-WRWVFLVNAVLALLALLLLLRLL 185
|
|
| FucP |
COG0738 |
Fucose permease [Carbohydrate transport and metabolism]; |
32-189 |
2.49e-06 |
|
Fucose permease [Carbohydrate transport and metabolism];
Pssm-ID: 440501 [Multi-domain] Cd Length: 391 Bit Score: 49.47 E-value: 2.49e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502820707 32 LLQKEFNLTAGQMGIFLSAFAWSYALLQLPIGPLLDKIGVKWVTRVATVIWTVACLLTAVANGWGLIILSRVLLGVGEAP 111
Cdd:COG0738 236 YLKDVLGLSEATAALGLSLFWGGMTIGRFLGGFLLKRFGPVRLLRLSALLAAVGLLLALLAPGPWLALIGLALVGLGLSL 315
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 502820707 112 FFPSAAKAVSHWVPRQeRGKAIAAYDSQSKLSNAIGAPILALIVTEWGWRGGFLATAILsFIYAIVYWIWYREPHEDE 189
Cdd:COG0738 316 MFPTIFSLALDGLGKR-TAAAVSAVLIMGIVGGAIGPPLIGFLADAFGLRAAFLVPLVC-YLLILLLALALKRKRRKK 391
|
|
| MFS_YajR_like |
cd17472 |
Escherichia coli inner membrane transport protein YajR and similar multidrug-efflux ... |
45-405 |
4.28e-06 |
|
Escherichia coli inner membrane transport protein YajR and similar multidrug-efflux transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli inner membrane transport protein YajR and some uncharacterized multidrug-efflux transporters. YajR is a putative proton-driven major facilitator superfamily (MFS) transporter found in many gram-negative bacteria. Unlike most MFS transporters, YajR contains a C-terminal, cytosolic YAM domain, which may play an essential role for the proper functioning of the transporter. YajR-like transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341025 [Multi-domain] Cd Length: 371 Bit Score: 48.37 E-value: 4.28e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502820707 45 GIFLSAFAWSYALLQLPIGPLLDKIGVKWVTRVATVIWTVACLLTAVANGWGLIILSRVLLGVGeapffpSAAKAVSHW- 123
Cdd:cd17472 35 GLALGIYGLTQAIFQIPFGLLSDRIGRKPVILFGLLLFIAGSLLAAYATSIYGLILGRALQGSG------AISSVVMALl 108
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502820707 124 ---VPRQERGKAIAAYDSQSKLSNAIGAPILALIVTEWGWRGGFLATAILSFIyAIVYWIWYRePHEDERLTKEEYDYiv 200
Cdd:cd17472 109 adlTREENRTKAMALIGASIGIAFAISMVLGPLLAAHLGVSGLFLITAILSLV-SLLILLFFV-PDPPKIVQISEKEK-- 184
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502820707 201 qggsqsseeakgsamENIRYLLTKRKVWAVFIGFAAYGYSWFLFLTWLPGYLAtemnmsilKSGWYSAIPWIVGTITeIV 280
Cdd:cd17472 185 ---------------KKLKKLLKNKRLLRLDFSIFILHFVLMAFFYILPLLLT--------QLGGGKGQLWKVYLPA-IL 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502820707 281 IGGWLVDRLINKGYNRTRVSKFFLVIGMVFGLSIIGAAFtHSANVAVFWISTAL--GGLVVTSAVAYSIPTFIAPKGTVG 358
Cdd:cd17472 241 IGFILMVPFVIYAEKKGKMKQVFVSSILLIAVGFLLLLF-AATSLWLLIIGLIIffIGFNLLEALLPSLVSKIAPKEYRG 319
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|
gi 502820707 359 TLTGLLTFGNNSMAIVAPITTGFIVQATGS---FMYAFLLAAAFLVIGIL 405
Cdd:cd17472 320 TAMGIYNTSQFLGSFLGGALGGLLWGLLGYssvFLTILILALLWLLVSFL 369
|
|
| emrD |
PRK11652 |
multidrug transporter EmrD; |
8-184 |
4.72e-06 |
|
multidrug transporter EmrD;
Pssm-ID: 183259 [Multi-domain] Cd Length: 394 Bit Score: 48.36 E-value: 4.72e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502820707 8 IVFLIAVGvvvnyfdRINMSI---AMPLLQKEFNLTAGQMGIFLSAFAWSYALLQLPIGPLLDKIGVKWVTRVATVIWTV 84
Cdd:PRK11652 13 LVLLVAVG-------QMAQTIyvpAIADMARDLNVREGAVQAVMAAYLLTYGLSQLFYGPLSDRVGRRPVILVGMSIFIL 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502820707 85 ACLLTAVANGWGLIILSRVLLGVGEApffpsAAKAVSHWVPRQ----ERGKAIAAYDSQSKLSNAIGAPILALIVTE-WG 159
Cdd:PRK11652 86 GTLVALFAHSLTVLIAASAIQGLGTG-----VGGVMARTLPRDlyegTQLRHANSLLNMGILVSPLLAPLIGGLLTTlFG 160
|
170 180
....*....|....*....|....*
gi 502820707 160 WRGGFLATAILSFIYAIVYWIWYRE 184
Cdd:PRK11652 161 WRACYLFLLLLGAGVTFSMARWMPE 185
|
|
| BtlA |
COG2270 |
MFS-type transporter involved in bile tolerance, Atg22 family [General function prediction ... |
280-405 |
4.95e-06 |
|
MFS-type transporter involved in bile tolerance, Atg22 family [General function prediction only];
Pssm-ID: 441871 [Multi-domain] Cd Length: 424 Bit Score: 48.61 E-value: 4.95e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502820707 280 VIGGWLVDRLINKgynrtRVSKFFLVIGMVfglSIIGAAFTHSAnvAVFWISTALGGLVVTSAVAYSIPTF--IAPKGTV 357
Cdd:COG2270 292 LLFGRLDDRIGPK-----RVILVSLVIWIV---VCLAAYFLTTA--LAFWILGLLIGLVMGGIQALSRSLLarLIPPGRE 361
|
90 100 110 120
....*....|....*....|....*....|....*....|....*...
gi 502820707 358 GTLTGLLTFGNNSMAIVAPITTGFIVQATGSFMYAFLLAAAFLVIGIL 405
Cdd:COG2270 362 AEFFGLYALSGKAASFLGPLLFGLVTQLTGSQRLGILSLIVFFVIGLV 409
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
230-422 |
1.10e-05 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 47.03 E-value: 1.10e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502820707 230 VFIGFAAYGYSWFLFLTWLPGYLATEMNMSILKSGWYSAIPWIVGTITeIVIGGWLVDRLINKgynrtrvsKFFLVIGMV 309
Cdd:pfam07690 1 LFLAAFLAALGRSLLGPALPLLLAEDLGISPTEIGLLLTLFSLGYALA-QPLAGRLSDRFGRR--------RVLLIGLLL 71
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502820707 310 FGLSIIGAAFTHsaNVAVFWISTALGGLV--VTSAVAYSIPTFIAPKGTVGTLTGLLTFGNNSMAIVAPITTGFIVQATG 387
Cdd:pfam07690 72 FALGLLLLLFAS--SLWLLLVLRVLQGLGagALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLFG 149
|
170 180 190
....*....|....*....|....*....|....*
gi 502820707 388 sFMYAFLLAAAFLVIGILSYTFLLTDLDPIESKES 422
Cdd:pfam07690 150 -WRAAFLILAILSLLAAVLLLLPRPPPESKRPKPA 183
|
|
| PRK10504 |
PRK10504 |
putative transporter; Provisional |
5-128 |
1.41e-05 |
|
putative transporter; Provisional
Pssm-ID: 182502 [Multi-domain] Cd Length: 471 Bit Score: 47.03 E-value: 1.41e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502820707 5 RWSIvFLIAVGVVVNYFDRINMSIAMPLLQKEFNLTAGQMGIFLSAFAWSYALLQLPIGPLLDKIGVKWVTRVATVIWTV 84
Cdd:PRK10504 9 RWQL-WIVAFGFFMQSLDTTIVNTALPSMAQSLGESPLHMHMVIVSYVLTVAVMLPASGWLADRVGVRNIFFTAIVLFTL 87
|
90 100 110 120
....*....|....*....|....*....|....*....|....
gi 502820707 85 ACLLTAVANGWGLIILSRVLLGVGEAPFFPSAAKAVSHWVPRQE 128
Cdd:PRK10504 88 GSLFCALSGTLNELLLARVLQGVGGAMMVPVGRLTVMKIVPREQ 131
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
225-422 |
1.57e-05 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 46.80 E-value: 1.57e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502820707 225 RKVWAVFIGFAAYGYSWFLFLTWLPgYLATEMNMSILKSGWYSAIPWIVGTITEIvIGGWLVDRLinkGYNRTrvskfFL 304
Cdd:COG2223 5 RVLLLATLAFFLAFGVWYLWSVLAP-PLAEEFGLSAAQLGLLFAIPVLVGALLRI-PLGFLVDRF---GPRRV-----LL 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502820707 305 VIGMVFGLSIIGAAFTHSANVAVFWISTALGGLVVTSAVAYSIPTFIAPKGTVGTLTGLLTFGNNSMAIVAPITTGFIVQ 384
Cdd:COG2223 75 IGLLLLGIGLLLLALAVSYWLLLLLGLLLGIGGGGSFAVGIALVSKWFPPDRRGLALGLAAGGGNLGAAVAAFLAPLLIA 154
|
170 180 190
....*....|....*....|....*....|....*...
gi 502820707 385 ATGsFMYAFLLAAAFLVIGILSYTFLLTDLDPIESKES 422
Cdd:COG2223 155 AFG-WRNAFLILGILLLVVAVLAWLFLRDPPAGAAAAA 191
|
|
| MFS_MdtH_MDR_like |
cd17329 |
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ... |
57-182 |
1.72e-05 |
|
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340887 [Multi-domain] Cd Length: 376 Bit Score: 46.84 E-value: 1.72e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502820707 57 LLQLPIGPLLDKIGVKWVTRVATVIWTVACLLTAVANGWGLIILSRVLLGVGEAPFFPSAAKAVSHWVPRQERGKAIAAY 136
Cdd:cd17329 251 LLQFPVARLVERFRLRKILMIGILLFAIGFAVLAFANTLAVLILAMIVLTLGEMLVFPAVQTLVAALAPPDKRGSYMGFY 330
|
90 100 110 120
....*....|....*....|....*....|....*....|....*.
gi 502820707 137 DSQSKLSNAIGAPILALIVTEWGWRGGFLATAILSFIYAIVYWIWY 182
Cdd:cd17329 331 ALAWGLGRAIGPLVGGLLLDLLGPGLPWLILAALGLIAAALLLGLQ 376
|
|
| PRK11102 |
PRK11102 |
Bcr/CflA family multidrug efflux MFS transporter; |
29-190 |
2.44e-05 |
|
Bcr/CflA family multidrug efflux MFS transporter;
Pssm-ID: 182964 [Multi-domain] Cd Length: 377 Bit Score: 46.06 E-value: 2.44e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502820707 29 AMPLLQKEFNLTAGQMGIFLSAFAWSYALLQLPIGPLLDKIGVKWVTRVATVIWTVACLLTAVANGWGLIILSRVLLGvg 108
Cdd:PRK11102 13 ALPVIAADFGVSAGSVQMTLSAYILGFAIGQLFYGPMADSFGRKPVILGGTLVFALAAVACALAQTIDQLIYMRFLHG-- 90
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502820707 109 eapFFPSAAKAVSHWVPRQERGKaiaayDSQSKLSNAIG-----APILALIVTEW-----GWRGGFLATAILSFIYAIVY 178
Cdd:PRK11102 91 ---LAAAAASVVINALMRDMFPK-----EEFSRMMSFVTlvmtiAPLLAPIIGGWllvwfSWHAIFWVLALAAILAAALV 162
|
170
....*....|..
gi 502820707 179 WIWYREPHEDER 190
Cdd:PRK11102 163 FFFIPETLPKER 174
|
|
| PRK14995 |
PRK14995 |
SmvA family efflux MFS transporter; |
5-122 |
2.94e-05 |
|
SmvA family efflux MFS transporter;
Pssm-ID: 184957 [Multi-domain] Cd Length: 495 Bit Score: 46.26 E-value: 2.94e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502820707 5 RWSIVFLIAVGVVVNYFDRINMSIAMPLLQKEFNLTAGQMGIFLSAFAWSYALLQLPIGPLLDKIGVKWVTRVATVIWTV 84
Cdd:PRK14995 4 QWLTLVIIVLVYIPVAIDATVLHVAAPTLSMTLGASGNELLWIIDIYSLVMAGMVLPMGALGDRIGFKRLLMLGGTLFGL 83
|
90 100 110
....*....|....*....|....*....|....*...
gi 502820707 85 ACLLTAVANGWGLIILSRVLLGVGEAPFFPSAAKAVSH 122
Cdd:PRK14995 84 ASLAAAFSPTASWLIATRALLAIGAAMIVPATLAGIRA 121
|
|
| PRK11551 |
PRK11551 |
putative 3-hydroxyphenylpropionic transporter MhpT; Provisional |
21-164 |
5.27e-05 |
|
putative 3-hydroxyphenylpropionic transporter MhpT; Provisional
Pssm-ID: 236927 [Multi-domain] Cd Length: 406 Bit Score: 45.34 E-value: 5.27e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502820707 21 FDRINMSIAMPLLQKEFNLTAGQMGIFLSAFAWSYALLQLPIGPLLDKIGVKWVTRVATVIWTVACLLTAVANGWGLIIL 100
Cdd:PRK11551 29 LDLQSAGVAAPRMAQEFGLDVAQMGWAFSAGILGLLPGALLGGRLADRIGRKRILIVSVALFGLFSLATAQAWDFPSLLV 108
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 502820707 101 SRVLLGVGEAPFFPSAAKAVSHWVPRQERGKAIAAYDSQSKLSNAIGAPILALIVTEWGWRGGF 164
Cdd:PRK11551 109 ARLLTGVGLGGALPNLIALTSEAVGPRLRGTAVSLMYCGVPFGGALASVIGVLAAGDAAWRHIF 172
|
|
| MFS_MdtG_MDR_like |
cd17391 |
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the ... |
45-180 |
6.24e-05 |
|
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli multidrug resistance protein MdtG, Streptococcus pneumoniae multidrug resistance efflux pump PmrA, and similar multidrug resistance (MDR) transporters from bacteria. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtG confers resistance to fosfomycin and deoxycholate. PmrA serves as an efflux pump for various substrates and is associated with fluoroquinolone resistance. MdtG-like MDR transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340949 [Multi-domain] Cd Length: 380 Bit Score: 44.95 E-value: 6.24e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502820707 45 GIFLSAFAWSYALLQLPIGPLLDKIGVKWVTRVATVIWTVACLL-TAVANGWGLIILsRVLLGVGEAPFFPSAAKAVSHW 123
Cdd:cd17391 243 GLVFSATGVSSLLSAPRLGKLGDRIGHHRILLGALLASALLYIPqAFVQTPWQLGIL-RFLLGLATGGLLPAINSLLAKI 321
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*..
gi 502820707 124 VPRQERGKAIAAYDSQSKLSNAIGAPILALIVTEWGWRGGFLATAILSFIYAIVYWI 180
Cdd:cd17391 322 TPKEVAGRIFGYNQSFQYLGNVAGPLLGSAIAAHFGYRAVFVVTALLVLLNAIWSFI 378
|
|
| 2A0108 |
TIGR00886 |
nitrite extrusion protein (nitrite facilitator); [Transport and binding proteins, Anions] |
32-334 |
9.02e-05 |
|
nitrite extrusion protein (nitrite facilitator); [Transport and binding proteins, Anions]
Pssm-ID: 273322 [Multi-domain] Cd Length: 354 Bit Score: 44.21 E-value: 9.02e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502820707 32 LLQKEFNLTAGQMGIFLSAFAWSYALLQLPIGPLLDKIGVKWVTRVATVIWTVACLL--TAVANGWGLIILsRVLLGVGE 109
Cdd:TIGR00886 27 LIKDDLGLSTAQLGNLVAVPVLAGAVLRIILGFLVDIFGPRYTTALSLLLLAIPCLWagLAVQSYSVLLLI-RLFIGIAG 105
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502820707 110 APFFPSAAKAvSHWVPRQERGKAIAAY----DSQSKLSNAIGAPILALI--------VTEWGWRGGFLATAILSFIYAIV 177
Cdd:TIGR00886 106 GSFASCMPWI-SFFFPKKIQGTALGLAagwgNMGGGVAQFVMPPIIGSLifgggqpaHLAWGWAFVIVPAGILLLPALLI 184
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502820707 178 YWIWYREPhederltkeeydyivqggSQSSEEAKGSAMENIRYLLTKRkVWAVFIgfaAYGYSWFLFLTW---LPGYLAT 254
Cdd:TIGR00886 185 FFVGADTP------------------PGKPATGKLSFKEALKVFGNRH-TWILAL---LYSVTFGSFLGVssiFAMLFKD 242
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502820707 255 EMNMSILKSGWYSAIPWIVGTITEiVIGGWLVDRLinkgyNRTRVSkFFLVIGMVFGLSIIGAAFTHSANVAVFWISTAL 334
Cdd:TIGR00886 243 QFGLSKVQAGAYASLGGFLGSLAR-PAGGAISDRL-----GGARKL-LMNFLGVAMGAFLVVLGLVSDGSLAAFIVLFVA 315
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
4-179 |
1.27e-04 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 43.95 E-value: 1.27e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502820707 4 HRWSIVFLIAVGVVVNYFDRINMSIAMP-LLQKEFNLTAGQMGIFLSAFAWSYALLQLPIGPLLDK-IGVKWVTRVATVI 81
Cdd:cd06174 200 LKNPGLWLLLLAIFLVNLAYYSFSTLLPlFLLDLGGLSVAVAGLLLSLFGLAGALGSLLLGLLSDRlIGRKPLLLIGLLL 279
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502820707 82 WTVACLLTAVANGWGLIILSRVLLGVGEAPFFPSAAKAVSHWVPRQERGKAIAAYDSQSKLSNAIGAPILA-LIVTEWGW 160
Cdd:cd06174 280 MALGLALLLLAPSLLLLLLLLLLLGFGLGGLLPLSFALIAELFPPEIRGTAFGLLNTFGFLGGAIGPLLAGfLLAATFGL 359
|
170
....*....|....*....
gi 502820707 161 RGGFLATAILSFIYAIVYW 179
Cdd:cd06174 360 TGAFLVLAVLLLLAAILLL 378
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
248-423 |
1.65e-04 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 43.72 E-value: 1.65e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502820707 248 LPGYlATEMNMSILKSGWYSAIPWIVGTITEIVIGgWLVDRLinkGYnrtrvsKFFLVIGMvFGLSIIGAAFTHSANVAV 327
Cdd:cd17325 19 LPLY-AESLGASVAQIGLIVAAYALAQLLFSPPAG-RLSDRF---GR------KRLLLLGL-LLLAVSTLLFAFATSYWQ 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502820707 328 FWISTALGGLV--VTSAVAYSIPTFIAPKGTVGTLTGLLTFGNNSMAIVAPITTGFIVQATGsFMYAFLLAAAFLVIGIL 405
Cdd:cd17325 87 LLLARFLQGLAsaAVWPAAMALIADIAPPEERGRAMGIFSSAIGLGFLIGPLLGGLLADALG-YRAPFLVCAALALLALV 165
|
170
....*....|....*...
gi 502820707 406 SYTFLLTDLDPIESKESI 423
Cdd:cd17325 166 LALLLLPEPRPPPNKRAV 183
|
|
| MFS_MCT_like |
cd17314 |
Monocarboxylate transporter (MCT) family and similar transporters of the Major Facilitator ... |
5-406 |
1.77e-04 |
|
Monocarboxylate transporter (MCT) family and similar transporters of the Major Facilitator Superfamily; The group is composed of the Monocarboxylate transporter (MCT) family in animals and similar transporters from fungi, plants, archaea, and bacteria. MCT is also called Solute carrier family 16 (SLC16 or SLC16A). It is composed of 14 members, MCT1-14. MCTs play an integral role in cellular metabolism via lactate transport and have been implicated in metabolic synergy in tumors. MCTs have been found to facilitate the transport across the plasma membrane not only of monocarboxylates (MCT1-4), but also thyroid hormones (MCT8/10), and aromatic acids (MCT10). Yeast MCT homologous (Mch) proteins are not involved in the uptake of monocarboxylates; their substrates are not known. The MCT-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340872 [Multi-domain] Cd Length: 385 Bit Score: 43.55 E-value: 1.77e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502820707 5 RWSIVFLIAVGVVVNYFDRINMSIAMPLLQKEFNLTAGQMGIFLSAFAWSYALLQLPIGPLLDKIGVKWVTRVATVIWTV 84
Cdd:cd17314 1 RWFVLYVSFLLSAMSTGFILSWSLFYQPWQDAFGYSSSQIATAASLSNLGMLLTQPILGFIADSFGPRPLMALAGIMVLA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502820707 85 ACLLTA-VANGWGLIILSRVLLGVGEAPFFPSAAKAVSHWVPrQERGKAIAAYDSQSKLSNAIGAPILALIVTEWGWRG- 162
Cdd:cd17314 81 GYTYLSyVFNSFPLSYACFVFIGAGTGILYGSAVLVTTQYFP-DTKGLALGLPTTGYSLGLVLGSPLLRILWVFYGLALv 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502820707 163 -GFLATAILSFIYAIVYWIWYREPHEderltkeeydyivqggsQSSEEAKGSAMENIRYLLTKRKVWAVFIGFaaygysw 241
Cdd:cd17314 160 yTILGILAAIVLSVVSLLGFKEPPDN-----------------QARLHVQKKKTQTMGEIFRDKVFWILFIAI------- 215
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502820707 242 flFLTWLPGYLATEMNMSILKSGWYSAIPWIVGTITEIVIG--------GWLVDRLINKGYNRTRVSKFFLVIGMVFGLS 313
Cdd:cd17314 216 --FLVLIGGFLFIANMASLVRSLQLDAPSFVTKLMSIYGLFnafgrllwGIVADFFGGRLSTLSILLTILGLGLCAFLFL 293
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502820707 314 IIGAAFTHSANVAVFWISTalGGLvvtSAVAYSIPTFIAPKGTVGTLTGLLTFGNNSMAIVAPITTGFIVQATGSFMYAF 393
Cdd:cd17314 294 LKMTPVGLVLTGSLLGFSY--GGL---FTVYPATVSTVFGTESFATLYGILLFAPAIGSILGPMLGAKFYDRTPSYISAV 368
|
410
....*....|....*
gi 502820707 394 LLAA--AFLVIGILS 406
Cdd:cd17314 369 YIYAviVFLASAILL 383
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
9-194 |
1.95e-04 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 43.35 E-value: 1.95e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502820707 9 VFLIAVGVVVNYFDRINMSIAMPLLQKEFNLTAGQMGIFLSAFAWSYALLQLPIGPLLDKIGVKWVTRVATVIWTVACLL 88
Cdd:COG2211 231 LLLLLAYLLFFLALALVAALLLYYFKYVLGLSAALVGLLLALYFLAALLGAPLWPRLAKRFGKKKAFIIGLLLAALGLLL 310
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502820707 89 TAVANG--WGLIILSRVLLGVGEAPFFPSAAKAVSHWVPRQE-------RGKAIAAYDSQSKLSNAIGAPILALIVTEWG 159
Cdd:COG2211 311 LFFLGPgnLWLLLVLAALAGIGLGAILVLPWAMLADVVDYDEwktgrrrEGLYFGIFTFAIKLGQALAGALAGLLLALFG 390
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|
gi 502820707 160 WRGG---------------FLATAILSFIYAIVYWIWYREPHEDERLTKE 194
Cdd:COG2211 391 YVAGaaqspsaltgirllfFLLPAVLLLLAALLLLFYPLTRERHAEIRAE 440
|
|
| PRK15402 |
PRK15402 |
MdfA family multidrug efflux MFS transporter; |
29-375 |
2.05e-04 |
|
MdfA family multidrug efflux MFS transporter;
Pssm-ID: 185300 [Multi-domain] Cd Length: 406 Bit Score: 43.39 E-value: 2.05e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502820707 29 AMPLLQKEFNLTAGQMGIFLSAFAWSYALLQLPIGPLLDKIGVKWVTRVATVIWTVACLLTAVANGWGLIILSRVLLG-- 106
Cdd:PRK15402 35 GMLAVVEDFNAGAEWVPTSMTAYLAGGMFLQWLLGPLSDRIGRRPVMLAGVAFFILTCLAILLAQSIEQFTLLRFLQGig 114
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502820707 107 ------VGEAPFFPSAAKAVSHwvprqergKAIAAYDSQSKLSNAIGaPILALIVTEWG-WRGGFLATAILSFIYAIVYW 179
Cdd:PRK15402 115 lcfigaVGYAAIQESFEEADAI--------KITALMANVALLAPLLG-PLVGAALIHVLpWRGMFVLFAALAALSFFGLW 185
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502820707 180 IWYREPHEDERltkeeydyivqggsqsSEEAKGSAMENIRYLLTKRKVWAvfiGFAAYGYSWFLFLTWL---PGYLATEM 256
Cdd:PRK15402 186 RAMPETAGRVG----------------EKLSLKELGRDYKLVLKNRRFVA---GALALGLVSLPLLAWIalsPVILISGE 246
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502820707 257 NMSILKSGWYSaIPWIVGTIteivIGGWLVDRLInkgyNRTRVSKFFLVIG--MVFGLSIIGAAFTHSANvAVFWISTAL 334
Cdd:PRK15402 247 QLSSYEYGLLQ-VPVFGALI----AGNLTLARLT----SRRPLRSLIRMGLwpMVAGLLLAALATVISSH-AYLWLTAGL 316
|
330 340 350 360
....*....|....*....|....*....|....*....|....*..
gi 502820707 335 G----GLVVTSAVAYSIPTFIAP--KGTVGTLTGLLtfgnnSMAIVA 375
Cdd:PRK15402 317 SlyafGIGLANAGLYRLTLFSSDvsKGTVSAAMGML-----SMLIFT 358
|
|
| MFS_MFSD9 |
cd17390 |
Major facilitator superfamily domain-containing protein 9; Major facilitator superfamily ... |
17-405 |
2.32e-04 |
|
Major facilitator superfamily domain-containing protein 9; Major facilitator superfamily domain-containing protein 9 (MFSD9) is expressed in the central nervous system (CNS) and in most peripheral tissues but at very low expression levels. The function of MFSD9 is unknown. MFSD9 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340948 [Multi-domain] Cd Length: 350 Bit Score: 42.98 E-value: 2.32e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502820707 17 VVNYFDRINMSIAMPLLQ---KEFNLTAGQMGIFLSAfawsYALLQLPIGPLL----DKIGVKWVTRVATVIWTVACLLT 89
Cdd:cd17390 3 LVGFLDLFGVSMILPLLSthiRSLGASPTVIGLIGSV----YGALQLFSSPLVgswsDVVGRRPVLLICLLLTALGYVLL 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502820707 90 AVANGWGLIILSRVLLGVgeapfFP---SAAKA-VSHWVPRQERGKAIAAYDSQSKLSNAIGaPILALIVTEwgWRGGF- 164
Cdd:cd17390 79 GFSTSLALLFLSRIPLGI-----FKhtqSLCKAyLSDLVSEQERSRVLGRFNAASSLGFILG-PVVGGHLAE--TDGGFy 150
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502820707 165 ---LATAILSFIYAIVYWIWYrephederltkeeydyivqggsqsseeakgsamenirylltkRKVWAVFIGFAAYGYSW 241
Cdd:cd17390 151 yvaLLCSAIFILNAGLVWFLL------------------------------------------SKLWDLLLVRFLMGFSV 188
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502820707 242 FLFLTWLPGYLATEMNMSILKSGWYSAIPWIVGTiteivIGGWLVDRLINKGYNRTrvSKFFLVIGMVFGLSIIGAAFTH 321
Cdd:cd17390 189 LLFRSNFSLYLEERFDLSPKTIGYLISYSGVLGA-----LSGFLVGRILKLYKNNE--YLLLLHSFILLALSLLGLALAP 261
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502820707 322 SANVAV-----FWISTALGGLVVTsavaySIPTFIAPKGTVGTLTGlltFGNNSMA---IVAPITTGFIVQATGSfmYAF 393
Cdd:cd17390 262 SIWLLVlcltpLSISSAVLRTCST-----SLLLSRGKSKERGTLLG---VGQSVTSlarILAPLLSGLLQEFSVS--GPG 331
|
410
....*....|..
gi 502820707 394 LLAAAFLVIGIL 405
Cdd:cd17390 332 LLGAVLALAAIL 343
|
|
| PRK11043 |
PRK11043 |
Bcr/CflA family multidrug efflux MFS transporter; |
34-176 |
2.38e-04 |
|
Bcr/CflA family multidrug efflux MFS transporter;
Pssm-ID: 182924 [Multi-domain] Cd Length: 401 Bit Score: 42.96 E-value: 2.38e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502820707 34 QKEFNLTAGQMGIFLSAFAWSYALLQLPIGPLLDKIGVKWVTRVATVIWTVACLLTA-VANGWGLIILsRVLLGVGeapf 112
Cdd:PRK11043 33 QADLQTSASAVSASLSLFLAGFALGQLLWGPLSDRYGRKPVLLAGLSLFALGSLGMLwVESAAQLLVL-RFVQAVG---- 107
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 502820707 113 fpSAAKAVShWvprqeRGKAIAAYDSQSK------------LSNAIgAPIL-ALIVTEWGWRGGFLATAILSFIYAI 176
Cdd:PRK11043 108 --VCSAAVI-W-----QALVIDRYPAQKAnrvfatimplvaLSPAL-APLLgAWLLNHFGWQAIFATLFAITLLLIL 175
|
|
| MFS_KgtP |
cd17367 |
Alpha-ketoglutarate permease of the Major Facilitator Superfamily of transporters; This ... |
13-310 |
3.91e-04 |
|
Alpha-ketoglutarate permease of the Major Facilitator Superfamily of transporters; This subfamily includes Escherichia coli alpha-ketoglutarate permease (KgtP) and similar proteins. KgtP is a constitutively expressed proton symporter that functions in the uptake of alpha-ketoglutarate across the boundary membrane. Also included is a putative transporter from Pseudomonas aeruginosa named dicarboxylic acid transporter PcaT. The KgtP subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340925 [Multi-domain] Cd Length: 407 Bit Score: 42.67 E-value: 3.91e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502820707 13 AVGVVVNYFDRINMSIAMPLLQKEFNLTAGQMGIFLSAFA-WSYALLQLPIGPLL-----DKIGVKWVTRVATVIWTVAC 86
Cdd:cd17367 5 SVGNLVEWYDWYVYAAFALYFAPQFFPSGDPTVALLSTAAvFAVGFLMRPIGGWLfgrlaDRIGRRAALTLSVSLMAAGS 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502820707 87 LLTAVANG------WGLIIL--SRVLLGVGEAPFFPSAAKAVSHWVPRQERGKAiaaydSQSKLSNAIGAPILALIV--- 155
Cdd:cd17367 85 LVIAVTPTyatigiWAPIILllARLLQGLSVGGEYGTSATYLSEVAPPGRRGFY-----SSFQYVTLIGGQLLALGVllv 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502820707 156 ----------TEWGWRGGFLATAILSFiyaIVYWIwyrephedeRLTKEEydyivqggSQSSEEAKGSAMEN---IRYLL 222
Cdd:cd17367 160 lqhtlgedqmAAWGWRIPFLLGGVLAV---VVLWL---------RRGLEE--------TESFEAIAESNEASagtLRELR 219
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502820707 223 TKRKVWAVFIGFAAYGYSWF-LFLTWLPGYLATEMNMSILKSGWYSAIPWIVGTITEIViGGWLVDRlinkgYNRTRVSK 301
Cdd:cd17367 220 RHPRELLLVVGLTAGGTLAFyTWTTYLQKFLVNTAGFSKGDATWITTAALLVFMLLQPL-GGRLSDR-----IGRRPLLL 293
|
....*....
gi 502820707 302 FFLVIGMVF 310
Cdd:cd17367 294 FFGIGGTLA 302
|
|
| PRK05122 |
PRK05122 |
major facilitator superfamily transporter; Provisional |
48-185 |
4.14e-04 |
|
major facilitator superfamily transporter; Provisional
Pssm-ID: 235348 [Multi-domain] Cd Length: 399 Bit Score: 42.56 E-value: 4.14e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502820707 48 LSAFAWSYALLQLPIGPLLDKIGVKWVTRVATVIWTVACLLTAVANGWGLIILSRVLLGVGEAPFFPSAAKAVSHWVPRQ 127
Cdd:PRK05122 255 LTLFGVAFVGARLLFGNLINRLGGLRVAIVSLLVEILGLLLLWLAPSPWMALIGAALTGFGFSLVFPALGVEAVKRVPPQ 334
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*...
gi 502820707 128 ERGKAIAAYDSQSKLSNAIGAPILALIVTEWGWRGGFLATAILSFIYAIVYWIWYREP 185
Cdd:PRK05122 335 NRGAALGAYSVFLDLSLGITGPLAGLVASWFGYPSIFLAAALAALLGLALTWLLYRRA 392
|
|
| 2A0119 |
TIGR00898 |
cation transport protein; [Transport and binding proteins, Cations and iron carrying compounds] |
31-180 |
6.37e-04 |
|
cation transport protein; [Transport and binding proteins, Cations and iron carrying compounds]
Pssm-ID: 273328 [Multi-domain] Cd Length: 505 Bit Score: 41.93 E-value: 6.37e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502820707 31 PLLQKEFNLtagqmGIFLSAFAWSYallqlpigpLLDKIGVKWVTRVATVIWTVACLLTAVANGWGLIILSRVLLGVGEA 110
Cdd:TIGR00898 130 DLTQSCFFV-----GVLLGSFVFGY---------LSDRFGRKKVLLLSTLVTAVSGVLTAFSPNYTVFLVFRLLVGMGIG 195
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 502820707 111 PFFPSAAKAVSHWVPRQERGKAIAAYDSqsklSNAIGAPILALI-VTEWGWRGGFLATAILSFIYAIVYWI 180
Cdd:TIGR00898 196 GIWVQAVVLNTEFLPKKQRAIVGTLIQV----FFSLGLVLLPLVaYFIPDWRWLQLAVSLPTFLFFLLSWF 262
|
|
| MFS_YxlH_like |
cd17490 |
Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This ... |
24-182 |
1.42e-03 |
|
Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Bacillus subtilis YxlH uncharacterized MFS-type transporter YxlH and similar proteins. The biological function of YxlH remains unclear. The YxlH-like subfamily belongs to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341043 [Multi-domain] Cd Length: 371 Bit Score: 40.67 E-value: 1.42e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502820707 24 INMSIAM---PLLQKEFNLTAGQMGIFLSAFAWSYALLQLPIGPLL-DKIGVKWVTRVATVIWTVACLLTAVANGWGLII 99
Cdd:cd17490 209 ITFSTTFgftPLIAKQLGASSFQLGLLSIIYLLPNALASLLSGTLFyKKLGERNTIIIGFLLLGAYCFLIPFAPNLTLLY 288
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502820707 100 LSRVLLGVGEAPFFPSAAKAVSHWVPRQERGKAIAAYDSQSKLSNAIGAPILALIVTEWGWRGGFLATAILSFIYAIVYW 179
Cdd:cd17490 289 LLQALNGFGTGILFPLLMSLSIEGVPAEQRSTAMGFFQAIYALGMFLGPVLVGIISEAFGLQTGFFVIGVIALLAAILSL 368
|
...
gi 502820707 180 IWY 182
Cdd:cd17490 369 AYY 371
|
|
| PRK11663 |
PRK11663 |
glucose-6-phosphate receptor/MFS transporter UhpC; |
5-177 |
2.08e-03 |
|
glucose-6-phosphate receptor/MFS transporter UhpC;
Pssm-ID: 183266 [Multi-domain] Cd Length: 434 Bit Score: 40.08 E-value: 2.08e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502820707 5 RWSIVFLIAVGVVVNYFDRINMSIAMPLLQKEFNLTAGQMGIFLSAFAWSYALLQLPIGPLLDKIGVKWVTRV------- 77
Cdd:PRK11663 21 RRHILITMYLGYALFYFTRKSFNAAMPEMLADLGLSRSDIGLLATLFYITYGVSKFVSGIVSDRSNARYFMGIgliatgi 100
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502820707 78 -------ATVIWTVACL--LTAVANGWGliilsrvllgvgeapfFPSAAKAVSHWVPRQERGKAIAAYDSQSKLSNAIGA 148
Cdd:PRK11663 101 inilfgfSSSLWAFALLwvLNAFFQGWG----------------WPVCAKLLTAWYSRTERGGWWAIWNTAHNVGGALIP 164
|
170 180
....*....|....*....|....*....
gi 502820707 149 PILALIVTEWGWRGGFLATAILSFIYAIV 177
Cdd:PRK11663 165 LVVGAIALHYGWRYGMMIAGIIAIVVGLF 193
|
|
| PRK03545 |
PRK03545 |
putative arabinose transporter; Provisional |
37-186 |
2.27e-03 |
|
putative arabinose transporter; Provisional
Pssm-ID: 179591 [Multi-domain] Cd Length: 390 Bit Score: 39.87 E-value: 2.27e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502820707 37 FNLTAGQMGIFLSAFAWSYALLQLPIGPLLDKIGVKWVTRVATVIWTVACLLTAVANGWGLIILSRVLLGVGEAPFFPSA 116
Cdd:PRK03545 39 FHMQTAQVGLMLTIYAWVVALMSLPLMLLTSNVERRKLLIGLFVLFIASHVLSALAWNFTVLLISRIGIAFAHAIFWSIT 118
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502820707 117 AKAVSHWVPRQERGKAIAAYDSQSKLSNAIGAPILALIVTEWGWRGGFLATAILSFIyaIVYWIWYREPH 186
Cdd:PRK03545 119 ASLAIRVAPAGKKAQALSLLATGTALAMVLGLPLGRVIGQYLGWRTTFLAIGGGALI--TLLLLIKLLPL 186
|
|
| MFS_XylE_like |
cd17359 |
D-xylose-proton symporter and similar transporters of the Major Facilitator Superfamily; This ... |
250-385 |
3.03e-03 |
|
D-xylose-proton symporter and similar transporters of the Major Facilitator Superfamily; This subfamily includes bacterial transporters such as D-xylose-proton symporter (XylE or XylT), arabinose-proton symporter (AraE), galactose-proton symporter (GalP), major myo-inositol transporter IolT, glucose transport protein, putative metabolite transport proteins YfiG, YncC, and YwtG, and similar proteins. The symporters XylE, AraE, and GalP facilitate the uptake of D-xylose, arabinose, and galactose, respectively, across the boundary membrane with the concomitant transport of protons into the cell. IolT is involved in polyol metabolism and myo-inositol degradation into acetyl-CoA. The XylE-like subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340917 [Multi-domain] Cd Length: 383 Bit Score: 39.47 E-value: 3.03e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502820707 250 GYLATEMNMSILKSGWYSAIPwIVGTITEIVIGGWLVDRLINKgynrtrvsKFFLVIGMVFGLSIIGAAFTHsaNVAVFW 329
Cdd:cd17359 25 PFLQTDFNLTPFLEGLVVSSA-LLGAAIGALFAGRLADRFGRR--------KTLLISAVLFFISALGSAFSP--NFTIFI 93
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*....
gi 502820707 330 ISTALGGLVVTSAVAYSiPTFI---APKGTVGTLTGLltfgnNSMAIVAPITTGFIVQA 385
Cdd:cd17359 94 IARIIGGLAVGGASALV-PMYIaevAPAEIRGRLVSL-----NQLMIVFGQLLAYIVNY 146
|
|
| MFS_ShiA_like |
cd17369 |
Shikimate transporter and similar proteins of the Major Facilitator Superfamily; This ... |
142-406 |
5.91e-03 |
|
Shikimate transporter and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli shikimate transporter (ShiA), inner membrane metabolite transport protein YhjE, and other putative metabolite transporters. ShiA is involved in the uptake of shikimate, an aromatic compound involved in siderophore biosynthesis. It has been suggested that YhjE may mediate the uptake of osmoprotectants. The ShiA-like subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340927 [Multi-domain] Cd Length: 408 Bit Score: 38.66 E-value: 5.91e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502820707 142 LSNAIGAPILALIVTE----WGWRGGFLATAILsfiYAIVYWIwyrephedeRLTKEEYDYIVqggsQSSEEAKGSAMEN 217
Cdd:cd17369 156 LATGVFLLLSALLSDEaflsWGWRIPFLLSAVL---VAVGLYI---------RLRLEETPVFR----RAKEAGQVVRAPL 219
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502820707 218 IRYLLTKRK-VWAVFIGFAAYGYSWFLFLTWLPGYLATEMNMSILKSGWYSAIPWIVGTITeIVIGGWLVDRlinkgYNR 296
Cdd:cd17369 220 VEVLRRHWRaLLLAIGLRLAENVLFYLFTTFALSYATQTLGVDRSTVLLAVLIASVVAAIT-IPLFGWLSDR-----VGR 293
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502820707 297 TRVSKFFLVIGMVFGLSIIGAAFTHSANVAVFWIstALGGLVVTSAVAYSIPTFIAPK-GTVGTLTGlLTFGNNSMAIV- 374
Cdd:cd17369 294 RPVYLAGALLAALFAFPFFWLLDTGSTWLIVLAA--VVVLGVLHGMMYGPQAAFLAELfPTRVRYTG-ASLGYQLGAILg 370
|
250 260 270
....*....|....*....|....*....|....*
gi 502820707 375 ---APITTGFIVQATGSFMYAFLLAAAFLVIGILS 406
Cdd:cd17369 371 ggfAPLIATALVAATGSWWPVALYLAALAVISLVA 405
|
|
| MFS_SLCO_OATP |
cd17336 |
Solute carrier organic anion transporters of the Major Facilitator Superfamily of transporters; ... |
9-114 |
6.15e-03 |
|
Solute carrier organic anion transporters of the Major Facilitator Superfamily of transporters; Solute carrier organic anion transporters (SLCOs) are also called organic anion transporting polypeptides (OATPs) or SLC21 (Solute carrier family 21) proteins. They are sodium-independent transporters that mediate the transport of a broad range of endo- as well as xenobiotics. Their substrates are mainly amphipathic organic anions with a molecular weight of more than 300Da, although there are a few known neutral or positively charged substrates. These include drugs including statins, angiotensin-converting enzyme inhibitors, angiotensin receptor blockers, antibiotics, antihistaminics, antihypertensives, and anticancer drugs. SLCOs/OATPs can be classified into 6 families (SLCO1-6 or OATP1-6) and each family may have subfamilies (e.g. OATP1A, OATP1B, OATP1C). Within the subfamilies, individual members are numbered according to the chronology of their identification and if there is already an ortholog known, they are given the same number. For example, the first SLCO identified, is rat OATP1A1 (encoded by the Slco1a1 gene). The second SLCO identified is the first human SLCO from the same subfamily and is called OATP1A2 (encoded by the SLCO1A2 gene). There are 11 human SLCOs/OATPs. SLCOs belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340894 [Multi-domain] Cd Length: 411 Bit Score: 38.76 E-value: 6.15e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502820707 9 VFLIAVGVVVNYFdrINMSIAmplLQKEFNLTAGQMGIFLSAFAWSYALLQLPIGPLLDKIG-VKWVTrVATVIWTVACL 87
Cdd:cd17336 10 LLGLLQGAVVSYF--VSTITT---IEKRFGLSSSQSGLILSANDIGQLLAVLLVSYFGGRGHrPRWIG-IGSILMGLGCF 83
|
90 100
....*....|....*....|....*..
gi 502820707 88 LTAVANgwgLIILSRVLLGVGEAPFFP 114
Cdd:cd17336 84 LLALPH---FLFVGQFLLGIGSSPLYT 107
|
|
| MFS_MFSD5_like |
cd17487 |
Major facilitator superfamily domain containing 5 protein; Human major facilitator superfamily ... |
272-405 |
8.43e-03 |
|
Major facilitator superfamily domain containing 5 protein; Human major facilitator superfamily domain containing 5 protein (MFSD5) is also called molybdate-anion transporter, or molybdate transporter 2 homolog (MOT2). It acts as an atypical solute carrier (SLC) that mediates high-affinity intracellular uptake of the rare oligo-element molybdenum. It may also play a role in maintaining the glucose homeostasis and pancreatic beta-cell proliferation, as well as in altered energy homeostasis. MFSD5 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341040 Cd Length: 385 Bit Score: 38.35 E-value: 8.43e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502820707 272 IVGTITeivigGWLVDRlinkgYNRTRVSkfflvigMVFGLSIIGAAFT-HSANVAVFWISTALGGL---VVTSA----- 342
Cdd:cd17487 53 VFGTFV-----GSLADK-----FGRKRAC-------LLFCVLYSLSCLTkHSPNFGVLLLGRVLGGIstsLLFSAfeswm 115
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 502820707 343 VAYSIPTFIAPKGTVGTLTGLLTFGNNSMAIVAPITTGFIVQATGSFMYAFLLAAAFLVIGIL 405
Cdd:cd17487 116 VHEHNKRGFFPKEWLSTTFSKATLGNGLVAILAGLVANFAEALGFGPVAPFDAAIPFLVLAGV 178
|
|
| synapt_SV2 |
TIGR01299 |
synaptic vesicle protein SV2; This model describes a tightly conserved subfamily of the larger ... |
3-160 |
8.80e-03 |
|
synaptic vesicle protein SV2; This model describes a tightly conserved subfamily of the larger family of sugar (and other) transporters described by pfam00083. Members of this subfamily include closely related forms SV2A and SV2B of synaptic vesicle protein from vertebrates and a more distantly related homolog (below trusted cutoff) from Drosophila melanogaster. Members are predicted to have two sets of six transmembrane helices.
Pssm-ID: 130366 [Multi-domain] Cd Length: 742 Bit Score: 38.42 E-value: 8.80e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502820707 3 KHRWSIVFLIAVGVVVNYFDRINMSIAMPLLQKEFNLTAGQ---------MGIFLSAFAWsyallqlpiGPLLDKIGVKW 73
Cdd:TIGR01299 163 RFQWALFFVLGLALMADGVEVFVVGFVLPSAEKDLCIPDSGkgmlglivyLGMMVGAFFW---------GGLADKLGRKQ 233
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502820707 74 VTRVATVIWTVACLLTAVANGWGLIILSRVLLGVGEAPFFPSAAKAVSHWVPRQERGKAIAAYDSQSKLSNAIGAPILAL 153
Cdd:TIGR01299 234 CLLICLSVNGFFAFFSSFVQGYGFFLFCRLLSGFGIGGAIPIVFSYFAEFLAQEKRGEHLSWLCMFWMIGGIYAAAMAWA 313
|
....*..
gi 502820707 154 IVTEWGW 160
Cdd:TIGR01299 314 IIPHYGW 320
|
|
| |
