NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|502820904|ref|WP_013055880|]
View 

MULTISPECIES: GntR family transcriptional regulator [Bacillaceae]

Protein Classification

GntR family transcriptional regulator( domain architecture ID 11450764)

GntR-family transcriptional regulator is one of a group of transcriptional regulators with a conserved N-terminal helix-turn-helix DNA-binding domain and a diverse C-terminal effector-binding and oligomerization domain

Gene Ontology:  GO:0003677|GO:0003700
PubMed:  2060763|26172911|33509775|15808743

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
MngR COG2188
DNA-binding transcriptional regulator, GntR family [Transcription];
5-241 5.30e-104

DNA-binding transcriptional regulator, GntR family [Transcription];


:

Pssm-ID: 441791 [Multi-domain]  Cd Length: 238  Bit Score: 300.63  E-value: 5.30e-104
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502820904   5 SSPLPIYYQIEEQLKKQIENGELKPNDSLPSEREFAERFEISRMTVRQAINNLVNDGYLYRQKGRGTFVSEKKLEQQLVG 84
Cdd:COG2188    1 SSPVPLYLQIADALRERIESGELPPGDRLPSERELAEEFGVSRMTVRKALDELVEEGLLERRQGRGTFVAEPKIEYPLSR 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502820904  85 LTSFTEDMKARGMVPSSKLLSFEIIAASEKIAEQLQISLHAPVYEIKRIRLADDVPMALESVYVSANLVKGLTES-IVND 163
Cdd:COG2188   81 LTSFTEELRARGREPSTRVLSAERVPADEEVAEALGLPPGAPVLRIERLRLADGEPVALETSYLPAALFPGLLEEdLETG 160

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 502820904 164 SLYRYIEEELGLKIGEANQTLESILASETEVKHLGISSYSPVLLIQRNTYLQDGTPLEVVKSSYRADRYKFTINMTRS 241
Cdd:COG2188  161 SLYELLEERYGLRITRAEQRIEAVLADAEEAELLGVPPGAPVLVIERVTYDADGRPVEYSRSYYRGDRYRFVVELRRR 238
 
Name Accession Description Interval E-value
MngR COG2188
DNA-binding transcriptional regulator, GntR family [Transcription];
5-241 5.30e-104

DNA-binding transcriptional regulator, GntR family [Transcription];


Pssm-ID: 441791 [Multi-domain]  Cd Length: 238  Bit Score: 300.63  E-value: 5.30e-104
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502820904   5 SSPLPIYYQIEEQLKKQIENGELKPNDSLPSEREFAERFEISRMTVRQAINNLVNDGYLYRQKGRGTFVSEKKLEQQLVG 84
Cdd:COG2188    1 SSPVPLYLQIADALRERIESGELPPGDRLPSERELAEEFGVSRMTVRKALDELVEEGLLERRQGRGTFVAEPKIEYPLSR 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502820904  85 LTSFTEDMKARGMVPSSKLLSFEIIAASEKIAEQLQISLHAPVYEIKRIRLADDVPMALESVYVSANLVKGLTES-IVND 163
Cdd:COG2188   81 LTSFTEELRARGREPSTRVLSAERVPADEEVAEALGLPPGAPVLRIERLRLADGEPVALETSYLPAALFPGLLEEdLETG 160

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 502820904 164 SLYRYIEEELGLKIGEANQTLESILASETEVKHLGISSYSPVLLIQRNTYLQDGTPLEVVKSSYRADRYKFTINMTRS 241
Cdd:COG2188  161 SLYELLEERYGLRITRAEQRIEAVLADAEEAELLGVPPGAPVLVIERVTYDADGRPVEYSRSYYRGDRYRFVVELRRR 238
UTRA smart00866
The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; ...
 94-233 3.65e-50

The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; It has a similar fold to HutC/FarR-like bacterial transcription factors of the GntR family. It is believed to modulate activity of bacterial transcription factors in response to binding small molecules.


Pssm-ID: 214869 [Multi-domain]  Cd Length: 143  Bit Score: 160.54  E-value: 3.65e-50
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502820904    94 ARGMVPSSKLLSFEIIAASEKIAEQLQISLHAPVYEIKRIRLADDVPMALESVYVSANLVKGLTESIVNDSLYRYIEEEL 173
Cdd:smart00866   1 AQGRKPTTKVLSFERVPADEELAEALGLPPGDPVYRIERLRLADGEPVALETTYLPAALFPGLLEEDLSGSLYEYLEERL 80

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 502820904   174 GLKI---GEANQTLESILASETEVKHLGISSYSPVLLIQRNTYLQDGTPLEVVKSSYRADRYK 233
Cdd:smart00866  81 GLKIvrsTRAEQTITAVLADEEEAELLGLPPGAPLLVVERVTYDDDGRPVEYSRSYYRGDRFR 143
UTRA pfam07702
UTRA domain; The UbiC transcription regulator-associated (UTRA) domain is a conserved ...
 94-233 6.18e-50

UTRA domain; The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain that has a similar fold to pfam04345. It is believed to modulate activity of bacterial transcription factors in response to binding small molecules sugar phosphates and urocanate, Matilla et. al., FEMS Microbiology Reviews, fuab043, 45, 2021, 1. https://doi.org/10.1093/femsre/fuab043).


Pssm-ID: 429607 [Multi-domain]  Cd Length: 141  Bit Score: 160.07  E-value: 6.18e-50
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502820904   94 ARGMVPSSKLLSFEIIAASEKIAEQLQISLHAPVYEIKRIRLADDVPMALESVYVSANLVKGLTESIV-NDSLYRYIEEE 172
Cdd:pfam07702   1 AQGREPKTEVLSLEEVPASAEIAEALGLPPGEPVYRIERLRYADGEPVALEEDYLPAELVPDLLEEDLeEGSLYDYLEER 80

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 502820904  173 LGLKIGEANQTLESILASETEVKHLGISSYSPVLLIQRNTYLQDGTPLEVVKSSYRADRYK 233
Cdd:pfam07702  81 YGLPITRAEQTIEAVLADAEEAELLGISPGAPVLLIERVTYDQDGRPVEYSRSYYRGDRYR 141
PRK09764 PRK09764
GntR family transcriptional regulator;
8-236 5.10e-48

GntR family transcriptional regulator;


Pssm-ID: 182065 [Multi-domain]  Cd Length: 240  Bit Score: 158.45  E-value: 5.10e-48
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502820904   8 LPIYYQIEEQLKKQIENGELKPNDSLPSEREFAERFEISRMTVRQAINNLVNDGYLYRQKGRGTFVSEKKLEQQLVGLTS 87
Cdd:PRK09764   4 KPLYRQIADRIREQIARGELKPGDALPTESALQTEFGVSRVTVRQALRQLVEQQILESIQGSGTYVKEERVNYDIFQLTS 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502820904  88 FTEDMKARGMVPSSKLLSFEIIAASEKIAEQLQISLHAPVYEIKRIRLADDVPMALESVYVSANLVKGLTESIVNDSLYR 167
Cdd:PRK09764  84 FDEKLSDRHVDTHSEVLIFEVIPADDFLQQQLQITAQDRVWHVKRVRYRKQKPMALEETWMPLALFPDLTWQVMENSKYH 163

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 502820904 168 YIEEELGLKIGEANQTLESILASETEVKHLGISSYSPVLLIQRNTYLQDGTPLEVVKSSYRADRYKFTI 236
Cdd:PRK09764 164 FIEEVKKMVIDRSEQEIIPLMPTEEMSRLLNISQTKPILEKVSRGYLVDGRVFEYSRNAFNTDDYKFTL 232
trehalos_R_Bsub TIGR02404
trehalose operon repressor, B. subtilis-type; This family consists of repressors of the GntR ...
 11-234 2.54e-45

trehalose operon repressor, B. subtilis-type; This family consists of repressors of the GntR family typically associated with trehalose utilization operons. Trehalose is imported as trehalose-6-phosphate and then hydrolyzed by alpha,alpha-phosphotrehalase to glucose and glucose-6-P. This family includes repressors mostly from Gram-positive lineages and does not include the TreR from E. coli. [Regulatory functions, DNA interactions]


Pssm-ID: 274116 [Multi-domain]  Cd Length: 233  Bit Score: 151.36  E-value: 2.54e-45
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502820904   11 YYQIEEQLKKQIENGELKPNDSLPSEREFAERFEISRMTVRQAINNLVNDGYLYRQKGRGTFV-SEKKLEQQLVGLTSFT 89
Cdd:TIGR02404   2 YEQIYQDLEQKITKGQYKEGDYLPSEHELMDQYGASRETVRKALNLLTERGYIQKIQGKGSIVlNRKQIEFPISGITSFK 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502820904   90 EDMKARGMVPSSKLLSFEIIAASEK-IAEQLQISLHAPVYEIKRIRLADDVPMALESVYVSANLVKGLTESIVNDSLYRY 168
Cdd:TIGR02404  82 ELNETLGLDSKTEVVELDKEDPLPEtLAQLTGLEEGSLIWRIKRVRVIDGEAVILDIDYLLKELVPGLTKEIAEDSIYQY 161

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 502820904  169 IEEELGLKIGEANQTLESILASETEVKHLGISSYSPVLLIQRNTYLQDGTPLEVVKSSYRADRYKF 234
Cdd:TIGR02404 162 LENELGLAISYAQKEITVEPCTDEDKKLLDLDGDDHVVVVKSKTFLEDTRQFQYTESRHRLDKFKF 227
WHTH_GntR cd07377
Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional ...
 9-74 8.52e-29

Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; This CD represents the winged HTH DNA-binding domain of the GntR (named after the gluconate operon repressor in Bacillus subtilis) family of bacterial transcriptional regulators and their putative homologs found in eukaryota and archaea. The GntR family has over 6000 members distributed among almost all bacterial species, which is comprised of FadR, HutC, MocR, YtrA, AraR, PlmA, and other subfamilies for the regulation of the most varied biological process. The monomeric proteins of the GntR family are characterized by two function domains: a small highly conserved winged helix-turn-helix prokaryotic DNA binding domain in the N-terminus, and a very diverse regulatory ligand-binding domain in the C-terminus for effector-binding/oligomerization, which provides the basis for the subfamily classifications. Binding of the effector to GntR-like transcriptional regulators is presumed to result in a conformational change that regulates the DNA-binding affinity of the repressor. The GntR-like proteins bind as dimers, where each monomer recognizes a half-site of 2-fold symmetric DNA sequences.


Pssm-ID: 153418 [Multi-domain]  Cd Length: 66  Bit Score: 103.30  E-value: 8.52e-29
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 502820904   9 PIYYQIEEQLKKQIENGELKPNDSLPSEREFAERFEISRMTVRQAINNLVNDGYLYRQKGRGTFVS 74
Cdd:cd07377    1 PLYEQIADQLREAILSGELKPGDRLPSERELAEELGVSRTTVREALRELEAEGLVERRPGRGTFVA 66
 
Name Accession Description Interval E-value
MngR COG2188
DNA-binding transcriptional regulator, GntR family [Transcription];
5-241 5.30e-104

DNA-binding transcriptional regulator, GntR family [Transcription];


Pssm-ID: 441791 [Multi-domain]  Cd Length: 238  Bit Score: 300.63  E-value: 5.30e-104
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502820904   5 SSPLPIYYQIEEQLKKQIENGELKPNDSLPSEREFAERFEISRMTVRQAINNLVNDGYLYRQKGRGTFVSEKKLEQQLVG 84
Cdd:COG2188    1 SSPVPLYLQIADALRERIESGELPPGDRLPSERELAEEFGVSRMTVRKALDELVEEGLLERRQGRGTFVAEPKIEYPLSR 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502820904  85 LTSFTEDMKARGMVPSSKLLSFEIIAASEKIAEQLQISLHAPVYEIKRIRLADDVPMALESVYVSANLVKGLTES-IVND 163
Cdd:COG2188   81 LTSFTEELRARGREPSTRVLSAERVPADEEVAEALGLPPGAPVLRIERLRLADGEPVALETSYLPAALFPGLLEEdLETG 160

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 502820904 164 SLYRYIEEELGLKIGEANQTLESILASETEVKHLGISSYSPVLLIQRNTYLQDGTPLEVVKSSYRADRYKFTINMTRS 241
Cdd:COG2188  161 SLYELLEERYGLRITRAEQRIEAVLADAEEAELLGVPPGAPVLVIERVTYDADGRPVEYSRSYYRGDRYRFVVELRRR 238
UTRA smart00866
The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; ...
 94-233 3.65e-50

The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; It has a similar fold to HutC/FarR-like bacterial transcription factors of the GntR family. It is believed to modulate activity of bacterial transcription factors in response to binding small molecules.


Pssm-ID: 214869 [Multi-domain]  Cd Length: 143  Bit Score: 160.54  E-value: 3.65e-50
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502820904    94 ARGMVPSSKLLSFEIIAASEKIAEQLQISLHAPVYEIKRIRLADDVPMALESVYVSANLVKGLTESIVNDSLYRYIEEEL 173
Cdd:smart00866   1 AQGRKPTTKVLSFERVPADEELAEALGLPPGDPVYRIERLRLADGEPVALETTYLPAALFPGLLEEDLSGSLYEYLEERL 80

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 502820904   174 GLKI---GEANQTLESILASETEVKHLGISSYSPVLLIQRNTYLQDGTPLEVVKSSYRADRYK 233
Cdd:smart00866  81 GLKIvrsTRAEQTITAVLADEEEAELLGLPPGAPLLVVERVTYDDDGRPVEYSRSYYRGDRFR 143
UTRA pfam07702
UTRA domain; The UbiC transcription regulator-associated (UTRA) domain is a conserved ...
 94-233 6.18e-50

UTRA domain; The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain that has a similar fold to pfam04345. It is believed to modulate activity of bacterial transcription factors in response to binding small molecules sugar phosphates and urocanate, Matilla et. al., FEMS Microbiology Reviews, fuab043, 45, 2021, 1. https://doi.org/10.1093/femsre/fuab043).


Pssm-ID: 429607 [Multi-domain]  Cd Length: 141  Bit Score: 160.07  E-value: 6.18e-50
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502820904   94 ARGMVPSSKLLSFEIIAASEKIAEQLQISLHAPVYEIKRIRLADDVPMALESVYVSANLVKGLTESIV-NDSLYRYIEEE 172
Cdd:pfam07702   1 AQGREPKTEVLSLEEVPASAEIAEALGLPPGEPVYRIERLRYADGEPVALEEDYLPAELVPDLLEEDLeEGSLYDYLEER 80

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 502820904  173 LGLKIGEANQTLESILASETEVKHLGISSYSPVLLIQRNTYLQDGTPLEVVKSSYRADRYK 233
Cdd:pfam07702  81 YGLPITRAEQTIEAVLADAEEAELLGISPGAPVLLIERVTYDQDGRPVEYSRSYYRGDRYR 141
PRK09764 PRK09764
GntR family transcriptional regulator;
8-236 5.10e-48

GntR family transcriptional regulator;


Pssm-ID: 182065 [Multi-domain]  Cd Length: 240  Bit Score: 158.45  E-value: 5.10e-48
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502820904   8 LPIYYQIEEQLKKQIENGELKPNDSLPSEREFAERFEISRMTVRQAINNLVNDGYLYRQKGRGTFVSEKKLEQQLVGLTS 87
Cdd:PRK09764   4 KPLYRQIADRIREQIARGELKPGDALPTESALQTEFGVSRVTVRQALRQLVEQQILESIQGSGTYVKEERVNYDIFQLTS 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502820904  88 FTEDMKARGMVPSSKLLSFEIIAASEKIAEQLQISLHAPVYEIKRIRLADDVPMALESVYVSANLVKGLTESIVNDSLYR 167
Cdd:PRK09764  84 FDEKLSDRHVDTHSEVLIFEVIPADDFLQQQLQITAQDRVWHVKRVRYRKQKPMALEETWMPLALFPDLTWQVMENSKYH 163

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 502820904 168 YIEEELGLKIGEANQTLESILASETEVKHLGISSYSPVLLIQRNTYLQDGTPLEVVKSSYRADRYKFTI 236
Cdd:PRK09764 164 FIEEVKKMVIDRSEQEIIPLMPTEEMSRLLNISQTKPILEKVSRGYLVDGRVFEYSRNAFNTDDYKFTL 232
PRK11402 PRK11402
transcriptional regulator PhoB;
1-241 6.95e-47

transcriptional regulator PhoB;


Pssm-ID: 183118 [Multi-domain]  Cd Length: 241  Bit Score: 155.76  E-value: 6.95e-47
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502820904   1 MIDKSSPLPIYYQIEEQLKKQIENGELKPNDSLPSEREFAERFEISRMTVRQAINNLVNDGYLYRQKGRGTFVSEKKLEQ 80
Cdd:PRK11402   1 ATDRYSHQLLYATVRQRLLDDIAQGVYQAGQQIPTENELCTQYNVSRITIRKAISDLVADGVLIRWQGKGTFVQSQKVEN 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502820904  81 QLVGLTSFTEDMKARGMVPSSKLLSFEIIAASEkIAEQLQISLHAPVYEIKRIRLADDVPMALESVYVSANLVKGLTESI 160
Cdd:PRK11402  81 ALLTVSGFTDFGVSQGKATKEKVIEQERVSAAP-FCEKLNIPGNSEVFHLCRVMYLDKEPLFIDSSWIPLSRYPDFDEIY 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502820904 161 VND-SLYRYIEEELGLKIGEANQTLESILASETEVKHLGISSYSPVLLIQRNTYLQDGTPLEVVKSSYRADRYKFTINMT 239
Cdd:PRK11402 160 VEGsSTYQLFQERFDTRVVSDKKTIDIFAATRPEAKWLKCELGEPLFRISKIAFDQNDKPVHVSELFCRANRVTLTIDNK 239


                 ..
gi 502820904 240 RS 241
Cdd:PRK11402 240 RH 241
trehalos_R_Bsub TIGR02404
trehalose operon repressor, B. subtilis-type; This family consists of repressors of the GntR ...
 11-234 2.54e-45

trehalose operon repressor, B. subtilis-type; This family consists of repressors of the GntR family typically associated with trehalose utilization operons. Trehalose is imported as trehalose-6-phosphate and then hydrolyzed by alpha,alpha-phosphotrehalase to glucose and glucose-6-P. This family includes repressors mostly from Gram-positive lineages and does not include the TreR from E. coli. [Regulatory functions, DNA interactions]


Pssm-ID: 274116 [Multi-domain]  Cd Length: 233  Bit Score: 151.36  E-value: 2.54e-45
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502820904   11 YYQIEEQLKKQIENGELKPNDSLPSEREFAERFEISRMTVRQAINNLVNDGYLYRQKGRGTFV-SEKKLEQQLVGLTSFT 89
Cdd:TIGR02404   2 YEQIYQDLEQKITKGQYKEGDYLPSEHELMDQYGASRETVRKALNLLTERGYIQKIQGKGSIVlNRKQIEFPISGITSFK 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502820904   90 EDMKARGMVPSSKLLSFEIIAASEK-IAEQLQISLHAPVYEIKRIRLADDVPMALESVYVSANLVKGLTESIVNDSLYRY 168
Cdd:TIGR02404  82 ELNETLGLDSKTEVVELDKEDPLPEtLAQLTGLEEGSLIWRIKRVRVIDGEAVILDIDYLLKELVPGLTKEIAEDSIYQY 161

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 502820904  169 IEEELGLKIGEANQTLESILASETEVKHLGISSYSPVLLIQRNTYLQDGTPLEVVKSSYRADRYKF 234
Cdd:TIGR02404 162 LENELGLAISYAQKEITVEPCTDEDKKLLDLDGDDHVVVVKSKTFLEDTRQFQYTESRHRLDKFKF 227
his_ut_repres TIGR02018
histidine utilization repressor, proteobacterial; This model represents a proteobacterial ...
 9-235 4.31e-42

histidine utilization repressor, proteobacterial; This model represents a proteobacterial histidine utilization repressor. It is usually found clustered with the enzymes HutUHIG so that it can regulate its own expression as well. A number of species have several paralogs and may fine-tune the regulation according to levels of degradation intermediates such as urocanate. This family belongs to the larger GntR family of transcriptional regulators. [Energy metabolism, Amino acids and amines, Regulatory functions, DNA interactions]


Pssm-ID: 188194 [Multi-domain]  Cd Length: 230  Bit Score: 142.84  E-value: 4.31e-42
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502820904    9 PIYYQIEEQLKKQIENGELKPNDSLPSEREFAERFEISRMTVRQAINNLVNDGYLYRQKGRGTFVSEKKLEQQLVGLTSF 88
Cdd:TIGR02018   1 PLYQRIKQDILERIRSGEWPPGHRIPSEHELVAQYGCSRMTVNRALRELTDAGLLERRQGVGTFVAEPKAQSALLEIRNI 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502820904   89 TEDMKARGMVPSSKLLSFEIIAASEKIAEQLQISLHAPVYEIKRIRLADDVPMALESVYVSANLV-----KGLTESIVND 163
Cdd:TIGR02018  81 ADEIVARGHRYRYELLELETRRATAEDAAALALPAGGKVFHSEIVHFENDVPFQLEDRLVNAAAVpdylkQDFTQTTPGA 160

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 502820904  164 SLYRYIeeelglKIGEANQTLESILASETEVKHLGISSYSPVLLIQRNTYLQDGtPLEVVKSSYRADRYKFT 235
Cdd:TIGR02018 161 YLSQAA------PLTEAEHRIEAISADPEEARLLAIDAGEPCLLIRRRTWSGAQ-VVTRARLLYPGSRYRLV 225
C_P_lyase_phnF TIGR02325
phosphonates metabolism transcriptional regulator PhnF; All members of the seed alignment for ...
 2-236 2.14e-39

phosphonates metabolism transcriptional regulator PhnF; All members of the seed alignment for this family are predicted helix-turn-helix transcriptional regulatory proteins of the broader gntR and are found associated with genes for the import and degradation of phosphonates and/or related compounds (e.g. phosphonites) with a direct C-P bond. [Transport and binding proteins, Anions, Regulatory functions, DNA interactions]


Pssm-ID: 131378 [Multi-domain]  Cd Length: 238  Bit Score: 136.07  E-value: 2.14e-39
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502820904    2 IDKSSPLPIYYQIEEQLKKQIENGELKPNDSLPSEREFAERFEISRMTVRQAINNLVNDGYLYRQKGRGTFVSEKKLEQQ 81
Cdd:TIGR02325   1 IERTSGVALWRQIADKIEQEIAAGHLRAGDYLPAEMQLAERFGVNRHTVRRAIAALVERGLLRAEQGRGTFVAARRIDYP 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502820904   82 LVGLTSFTEDMKARGMVPSSKLLSFEIIAASEKIAEQLQISLHAPVYEIKRIRLADDVPMALESVYVSANLVKGLTESIV 161
Cdd:TIGR02325  81 LSARTRFSQNLADQGREPTGELLLSDLEPASAELADALGLTVGAPLVRLETLRKADGRPLCRATTWFPAARFPGIGQAYA 160

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 502820904  162 ND-SLYRYIEEELGLKIGEANQTLESILASETEVKHLGISSYSPVLLIQRNTYLQDGTPLEVVKSSYRADRYKFTI 236
Cdd:TIGR02325 161 ASgSITDALREQGVADYRRSSTRISARHADAKDCARLELPPGRPLLVVQALNHDGEGRPVQYSVSRFRADRVEFTM 236
WHTH_GntR cd07377
Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional ...
 9-74 8.52e-29

Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; This CD represents the winged HTH DNA-binding domain of the GntR (named after the gluconate operon repressor in Bacillus subtilis) family of bacterial transcriptional regulators and their putative homologs found in eukaryota and archaea. The GntR family has over 6000 members distributed among almost all bacterial species, which is comprised of FadR, HutC, MocR, YtrA, AraR, PlmA, and other subfamilies for the regulation of the most varied biological process. The monomeric proteins of the GntR family are characterized by two function domains: a small highly conserved winged helix-turn-helix prokaryotic DNA binding domain in the N-terminus, and a very diverse regulatory ligand-binding domain in the C-terminus for effector-binding/oligomerization, which provides the basis for the subfamily classifications. Binding of the effector to GntR-like transcriptional regulators is presumed to result in a conformational change that regulates the DNA-binding affinity of the repressor. The GntR-like proteins bind as dimers, where each monomer recognizes a half-site of 2-fold symmetric DNA sequences.


Pssm-ID: 153418 [Multi-domain]  Cd Length: 66  Bit Score: 103.30  E-value: 8.52e-29
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 502820904   9 PIYYQIEEQLKKQIENGELKPNDSLPSEREFAERFEISRMTVRQAINNLVNDGYLYRQKGRGTFVS 74
Cdd:cd07377    1 PLYEQIADQLREAILSGELKPGDRLPSERELAEELGVSRTTVREALRELEAEGLVERRPGRGTFVA 66
PRK14999 PRK14999
histidine utilization repressor; Provisional
 4-213 2.99e-26

histidine utilization repressor; Provisional


Pssm-ID: 184961 [Multi-domain]  Cd Length: 241  Bit Score: 101.93  E-value: 2.99e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502820904   4 KSSPLPIYYQIEEQLKKQIENGELKPNDSLPSEREFAERFEISRMTVRQAINNLVNDGYLYRQKGRGTFVSEKKLEQQLV 83
Cdd:PRK14999   7 RSAPAPFYETVKQDICKKIAGGVWQPHDRIPSEAELVAQYGFSRMTINRALRELTDEGWLVRLQGVGTFVAEPKGQSALF 86

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502820904  84 GLTSFTEDMKARGMVPSSKLLSFEIIAASEKIAEQLQISLHAPVYEIKRIRLADDVPMALESVYVSANLVKG-LTESIVN 162
Cdd:PRK14999  87 EVRSIAEEIAARRHQHRCEVLTLERVRANAIQASALNVNESDVIFHSIMVHYENDLPVQIEDRCVNADIAVDyLTQDYRQ 166

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|.
gi 502820904 163 DSLYRYIEEELGLKIGEanQTLESILASETEVKHLGISSYSPVLLIQRNTY 213
Cdd:PRK14999 167 TTPHAYLSRIAPLTEGE--HIVEAVRATAQECAWLTIKEHEPCLLIRRTTW 215
YhcF COG1725
DNA-binding transcriptional regulator YhcF, GntR family [Transcription];
1-92 5.25e-26

DNA-binding transcriptional regulator YhcF, GntR family [Transcription];


Pssm-ID: 441331 [Multi-domain]  Cd Length: 114  Bit Score: 97.56  E-value: 5.25e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502820904   1 MIDKSSPLPIYYQIEEQLKKQIENGELKPNDSLPSEREFAERFEISRMTVRQAINNLVNDGYLYRQKGRGTFVSEKKLEQ 80
Cdd:COG1725    2 RIDFDSGVPIYEQIADQIKEAIASGELKPGDRLPSVRELAAELGVNPNTVAKAYRELEDEGLIETRRGKGTFVAEDAREL 81

                         90
                 ....*....|..
gi 502820904  81 QLVGLTSFTEDM 92
Cdd:COG1725   82 LEERREEFLEEA 93
ARO8 COG1167
DNA-binding transcriptional regulator, MocR family, contains an aminotransferase domain ...
 1-75 1.35e-22

DNA-binding transcriptional regulator, MocR family, contains an aminotransferase domain [Transcription, Amino acid transport and metabolism]; DNA-binding transcriptional regulator, MocR family, contains an aminotransferase domain is part of the Pathway/BioSystem: Lysine biosynthesis


Pssm-ID: 440781 [Multi-domain]  Cd Length: 471  Bit Score: 95.28  E-value: 1.35e-22
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 502820904   1 MIDKSSPLPIYYQIEEQLKKQIENGELKPNDSLPSEREFAERFEISRMTVRQAINNLVNDGYLYRQKGRGTFVSE 75
Cdd:COG1167    4 RLDRDSSGPLYLQLADALREAILSGRLPPGDRLPSSRELAAQLGVSRSTVVRAYEELEAEGLIESRPGSGTFVAA 78
FadR COG2186
DNA-binding transcriptional regulator, FadR family [Transcription];
4-75 1.78e-21

DNA-binding transcriptional regulator, FadR family [Transcription];


Pssm-ID: 441789 [Multi-domain]  Cd Length: 232  Bit Score: 89.22  E-value: 1.78e-21
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 502820904   4 KSSPLPIYYQIEEQLKKQIENGELKPNDSLPSEREFAERFEISRMTVRQAINNLVNDGYLYRQKGRGTFVSE 75
Cdd:COG2186    2 PIRRRSLAEQVAEQLRELILSGELKPGDRLPSERELAEQLGVSRTTVREALRALEALGLVEVRQGGGTFVRE 73
GntR pfam00392
Bacterial regulatory proteins, gntR family; This family of regulatory proteins consists of the ...
 11-73 4.91e-20

Bacterial regulatory proteins, gntR family; This family of regulatory proteins consists of the N-terminal HTH region of GntR-like bacterial transcription factors. At the C-terminus there is usually an effector-binding/oligomerization domain. The GntR-like proteins include the following sub-families: MocR, YtrR, FadR, AraR, HutC and PlmA, DevA, DasR. Many of these proteins have been shown experimentally to be autoregulatory, enabling the prediction of operator sites and the discovery of cis/trans relationships. The DasR regulator has been shown to be a global regulator of primary metabolism and development in Streptomyces coelicolor.


Pssm-ID: 306822 [Multi-domain]  Cd Length: 64  Bit Score: 80.74  E-value: 4.91e-20
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 502820904   11 YYQIEEQLKKQIENGELKPNDSLPSEREFAERFEISRMTVRQAINNLVNDGYLYRQKGRGTFV 73
Cdd:pfam00392   2 YEQVYARLREDILSGRLRPGDKLPSERELAAEFGVSRTTVREALRRLEAEGLVERRQGRGTFV 64
PRK10079 PRK10079
phosphonate metabolism transcriptional regulator PhnF; Provisional
 10-236 8.38e-20

phosphonate metabolism transcriptional regulator PhnF; Provisional


Pssm-ID: 182227 [Multi-domain]  Cd Length: 241  Bit Score: 84.83  E-value: 8.38e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502820904  10 IYYQIEEQLKKQIENGelkpnDSLPSEREFAERFEISRMTVRQAINNLVNDGYLYRQKGRGTFVSEKKLEQQLVGLTSFT 89
Cdd:PRK10079  17 IAAKLEQELRQHYRCG-----DYLPAEQQLAARYEVNRHTLRRAIDQLVEKGWVQRRQGVGVLVLMRPYDYPLNAQARFS 91

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502820904  90 EDMKARGMVPSSKLLSFEIIAASEKIAEQLQISLHAPVYEIKRIRLADDVPMALESVYVSANLVKGLTESIVNDSLYRYI 169
Cdd:PRK10079  92 QNLLDQGSHPTSEKLLSVLRPASGHVADALGITEGENVIHLRTLRRVNGVALCLIDHYFADLTWWPTLQRFDSGSLHDFL 171

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 502820904 170 EEELGLKIGEANQTLESILASETEVKHLGISSYSPVLLIQR-NTYLQDGTPLEVVKSSYRADRYKFTI 236
Cdd:PRK10079 172 REQLGIALRRSQTRISARRAQAKESQLLEIPNMSPLLCVRTlNHRDGESSPAEYSVSLTRADMIEFTM 239
HTH_GNTR smart00345
helix_turn_helix gluconate operon transcriptional repressor;
14-73 3.95e-19

helix_turn_helix gluconate operon transcriptional repressor;


Pssm-ID: 197669 [Multi-domain]  Cd Length: 60  Bit Score: 78.00  E-value: 3.95e-19
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 502820904    14 IEEQLKKQIENGELKPNDSLPSEREFAERFEISRMTVRQAINNLVNDGYLYRQKGRGTFV 73
Cdd:smart00345   1 VAERLREDIVSGELRPGDKLPSERELAAQLGVSRTTVREALSRLEAEGLVQRRPGSGTFV 60
GntR COG1802
DNA-binding transcriptional regulator, GntR family [Transcription];
13-75 6.36e-14

DNA-binding transcriptional regulator, GntR family [Transcription];


Pssm-ID: 441407 [Multi-domain]  Cd Length: 222  Bit Score: 68.41  E-value: 6.36e-14
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 502820904  13 QIEEQLKKQIENGELKPNDSLpSEREFAERFEISRMTVRQAINNLVNDGYLYRQKGRGTFVSE 75
Cdd:COG1802   15 QVYEALREAILSGELPPGERL-SEAELAERLGVSRTPVREALRRLEAEGLVEIRPNRGARVAP 76
pdhR PRK09464
pyruvate dehydrogenase complex transcriptional repressor PdhR;
14-82 1.59e-13

pyruvate dehydrogenase complex transcriptional repressor PdhR;


Pssm-ID: 181879 [Multi-domain]  Cd Length: 254  Bit Score: 67.74  E-value: 1.59e-13
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 502820904  14 IEEQLKKQIENGELKPNDSLPSEREFAERFEISRMTVRQAINNLVNDGYLYRQKGRGTFVSEkKLEQQL 82
Cdd:PRK09464  15 IEQQLEFLILEGTLRPGEKLPPERELAKQFDVSRPSLREAIQRLEAKGLLLRRQGGGTFVQS-SLWQSF 82
PRK10421 PRK10421
DNA-binding transcriptional repressor LldR; Provisional
 13-83 1.43e-10

DNA-binding transcriptional repressor LldR; Provisional


Pssm-ID: 236690 [Multi-domain]  Cd Length: 253  Bit Score: 59.40  E-value: 1.43e-10
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 502820904  13 QIEEQLKKQIENGELKPNDSLPSEREFAERFEISRMTVRQAINNLVNDGYLYRQKGRGTFVS---EKKLEQQLV 83
Cdd:PRK10421   6 EVADRVRALIEEKNLEAGMKLPAERQLAMQLGVSRNSLREALAKLVSEGVLLSRRGGGTFIRwrhETWSEQNIV 79
PRK11523 PRK11523
transcriptional regulator ExuR;
10-73 1.47e-08

transcriptional regulator ExuR;


Pssm-ID: 183176 [Multi-domain]  Cd Length: 253  Bit Score: 53.70  E-value: 1.47e-08
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 502820904  10 IYYQIEEQLKKQIENGELKPNDSLPSEREFAERFEISRMTVRQAINNLVNDGYLYRQKGRGTFV 73
Cdd:PRK11523   9 LYQQLAAELKERIEQGVYLVGDKLPAERFIADEKNVSRTVVREAIIMLEVEGYVEVRKGSGIHV 72
PRK03837 PRK03837
transcriptional regulator NanR; Provisional
 1-61 3.24e-08

transcriptional regulator NanR; Provisional


Pssm-ID: 235166 [Multi-domain]  Cd Length: 241  Bit Score: 52.72  E-value: 3.24e-08
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 502820904   1 MIDKSSPL---PIYYQIEEQLKKQIENGELKPNDSLPSEREFAERFEISRMTVRQAINNLVNDG 61
Cdd:PRK03837   2 RNLRSRPIarkKLSEEVEERLEQMIRSGEFGPGDQLPSERELMAFFGVGRPAVREALQALKRKG 65
PRK15481 PRK15481
transcriptional regulatory protein PtsJ; Provisional
 13-75 9.22e-07

transcriptional regulatory protein PtsJ; Provisional


Pssm-ID: 185378 [Multi-domain]  Cd Length: 431  Bit Score: 48.89  E-value: 9.22e-07
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 502820904  13 QIEEQLKKQIENGELKPNDSLPSEREFAERFEISRMTVRQAINNLVNDGYLYRQKGRGTFVSE 75
Cdd:PRK15481   9 EIFDSIRQLIQAGRLRPGDSLPPVRELASELGVNRNTVAAAYKRLVTAGLAQSQGRNGTVIRG 71
PRK10225 PRK10225
Uxu operon transcriptional regulator;
1-77 6.59e-06

Uxu operon transcriptional regulator;


Pssm-ID: 182318 [Multi-domain]  Cd Length: 257  Bit Score: 45.78  E-value: 6.59e-06
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 502820904   1 MIDKSSPLPIYYQIEEQLKKQIENGELKPNDSLPSEREFAERFEISRMTVRQAINNLVNDGYLYRQKGRGTFVSEKK 77
Cdd:PRK10225   1 MKSATSAQRPYQEVGAMIRDLIIKTPYNPGERLPPEREIAEMLDVTRTVVREALIMLEIKGLVEVRRGAGIYVLDSS 77
PRK09990 PRK09990
DNA-binding transcriptional regulator GlcC; Provisional
 3-75 3.60e-05

DNA-binding transcriptional regulator GlcC; Provisional


Pssm-ID: 182186 [Multi-domain]  Cd Length: 251  Bit Score: 43.60  E-value: 3.60e-05
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 502820904   3 DKSSPLPIYYQIEEQLKKQIENGELKPNDSLPSEREFAERFEISRMTVRQAINNLVNDGYLYRQKGRGTFVSE 75
Cdd:PRK09990   1 MKDERRPIADVVAERIERLIVDGVLKVGQALPSERRLCEKLGFSRSALREGLTVLRGRGIIETAQGRGSFVAR 73
PRK04984 PRK04984
fatty acid metabolism transcriptional regulator FadR;
15-73 1.72e-03

fatty acid metabolism transcriptional regulator FadR;


Pssm-ID: 179909 [Multi-domain]  Cd Length: 239  Bit Score: 38.70  E-value: 1.72e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 502820904  15 EEQLKKQIENGELKPNDSLPSEREFAERFEISRMTVRQAINNLVNDGYLYRQKGRGTFV 73
Cdd:PRK04984  13 EEYIIESIWNNRFPPGSILPAERELSELIGVTRTTLREVLQRLARDGWLTIQHGKPTKV 71
UTRA pfam07702
UTRA domain; The UbiC transcription regulator-associated (UTRA) domain is a conserved ...
 78-140 3.70e-03

UTRA domain; The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain that has a similar fold to pfam04345. It is believed to modulate activity of bacterial transcription factors in response to binding small molecules sugar phosphates and urocanate, Matilla et. al., FEMS Microbiology Reviews, fuab043, 45, 2021, 1. https://doi.org/10.1093/femsre/fuab043).


Pssm-ID: 429607 [Multi-domain]  Cd Length: 141  Bit Score: 36.81  E-value: 3.70e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 502820904   78 LEQQLVGLTSFTEDMKAR-GMVPSSKLLSFEIIAASEKIAEQLQISLHAPVYEIKRI-RLADDVP 140
Cdd:pfam07702  63 LLEEDLEEGSLYDYLEERyGLPITRAEQTIEAVLADAEEAELLGISPGAPVLLIERVtYDQDGRP 127
UTRA smart00866
The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; ...
 88-147 4.18e-03

The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; It has a similar fold to HutC/FarR-like bacterial transcription factors of the GntR family. It is believed to modulate activity of bacterial transcription factors in response to binding small molecules.


Pssm-ID: 214869 [Multi-domain]  Cd Length: 143  Bit Score: 36.50  E-value: 4.18e-03
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 502820904    88 FTEDMKARGMVPSSKLLSFEIIAASEKIAEQLQISLHAPVYEIKRIR-LADDVPMAL-ESVY 147
Cdd:smart00866  76 LEERLGLKIVRSTRAEQTITAVLADEEEAELLGLPPGAPLLVVERVTyDDDGRPVEYsRSYY 137
COG2345 COG2345
Predicted transcriptional regulator, ArsR family [Transcription];
40-70 4.34e-03

Predicted transcriptional regulator, ArsR family [Transcription];


Pssm-ID: 441914 [Multi-domain]  Cd Length: 217  Bit Score: 37.21  E-value: 4.34e-03
                         10        20        30
                 ....*....|....*....|....*....|....
gi 502820904  40 AERFEISRMTVRQAINNLVNDGYL---YRQKGRG 70
Cdd:COG2345   34 AEALGLTPNAVRRHLDALEEEGLVereTERRGRG 67
HTH_DeoR pfam08220
DeoR-like helix-turn-helix domain;
38-76 5.38e-03

DeoR-like helix-turn-helix domain;


Pssm-ID: 285436 [Multi-domain]  Cd Length: 57  Bit Score: 34.16  E-value: 5.38e-03
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 502820904   38 EFAERFEISRMTVRQAINNLVNDGYLYRQKGRGTFVSEK 76
Cdd:pfam08220  19 ELAELLGVSEMTIRRDLNELEEQGLLTRTHGGAVSNSST 57
HTH_DEOR smart00420
helix_turn_helix, Deoxyribose operon repressor;
38-68 9.97e-03

helix_turn_helix, Deoxyribose operon repressor;


Pssm-ID: 197714 [Multi-domain]  Cd Length: 53  Bit Score: 33.35  E-value: 9.97e-03
                           10        20        30
                   ....*....|....*....|....*....|.
gi 502820904    38 EFAERFEISRMTVRQAINNLVNDGYLYRQKG 68
Cdd:smart00420  19 ELAELLGVSEMTIRRDLNKLEEQGLLTRVHG 49
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH