|
Name |
Accession |
Description |
Interval |
E-value |
| NlpA |
COG1464 |
ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion ... |
1-275 |
1.25e-127 |
|
ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism];
Pssm-ID: 441073 [Multi-domain] Cd Length: 270 Bit Score: 363.28 E-value: 1.25e-127
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502821327 1 MKKFVWLFALLAVITVVGGCGNKEKASGQNSDKkediVLKVGAASTPHAEILKYVEPDLKKEGIKLDIVNIKDGIQTNEQ 80
Cdd:COG1464 1 MKKLLALLLALALALALAACGSSSAAAAAADKK----TIKVGATPGPHAEILEVVKPELAKKGIDLEIVEFTDYVQPNEA 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502821327 81 TANGELDANYFQHTPYLKQTNKDSGLNLVNVTNVHIEPFGVYSKKIKSIDDLSKGAKVAVPNDPVNFSRALELFQANGII 160
Cdd:COG1464 77 LADGEIDANYFQHIPYLDNFNKENGYDLVPVGKTHIEPMGLYSKKYKSLDELPDGATIAIPNDPTNQGRALLLLQKAGLI 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502821327 161 ELnKKPSGSSYTVEDISKNKKKLDFVAVDGPLLVRSLDDVEASAINTNYALEGGFKPTKDALIIEKKESPYVNILVTTKE 240
Cdd:COG1464 157 KL-KDGVGLLATVKDITENPKNLKFVELDAAQLPRSLDDVDAAVINGNYALEAGLDPTKDALFLEDKDSPYANIIVVRED 235
|
250 260 270
....*....|....*....|....*....|....*
gi 502821327 241 KKDDKNIQRLAKALTTDKVKKFINDKYDGAVVPAF 275
Cdd:COG1464 236 DKDDPAIKKLVEAYQSDEVKKFIEEKYKGAVVPAW 270
|
|
| PBP2_lipoprotein_Tp32 |
cd13597 |
The substrate-binding domain of the 32-kilodalton lipoprotein (Tp32) from Treponema pallidum ... |
38-273 |
5.04e-109 |
|
The substrate-binding domain of the 32-kilodalton lipoprotein (Tp32) from Treponema pallidum binds L-methionine; the type 2 periplasmic-binding protein fold; This group includes the lipoprotein Tp32, a periplasmic component of a methionine uptake transporter system, and its closely related homologs. The Tp32 has both structural and sequential homology to the MetQ family of substrate-binding protein, and thus it belongs to the type 2 periplasmic binding fold protein superfamily (PBP2). The PBP2 proteins are typically comprised of two globular subdomains connected by a flexible hinge and bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap. The majority of PBP2 proteins function in the uptake of small soluble substrates in eubacteria and archaea.
Pssm-ID: 270315 Cd Length: 236 Bit Score: 314.98 E-value: 5.04e-109
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502821327 38 VLKVGAASTPHAEILKYVEPDLKKEGIKLDIVNIKDGIQTNEQTANGELDANYFQHTPYLKQTNKDSGLNLVNVTNVHIE 117
Cdd:cd13597 1 TLKVGATPVPHAEILEFIKPELKKQGIDLEIVEFTDYVQPNTALADGELDANYFQHVPYLESFNKEKGYDLVAVAGVHLE 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502821327 118 PFGVYSKKIKSIDDLSKGAKVAVPNDPVNFSRALELFQANGIIELnKKPSGSSYTVEDISKNKKKLDFVAVDGPLLVRSL 197
Cdd:cd13597 81 PMGLYSKKYKSLEDLPDGATIAIPNDPTNQGRALLLLEEAGLITL-KDGAGLTATVKDIVKNPKNLKFKELEAAQLPRSL 159
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 502821327 198 DDVEASAINTNYALEGGFKPTKDALIIEKKE-SPYVNILVTTKEKKDDKNIQRLAKALTTDKVKKFINDKYDGAVVP 273
Cdd:cd13597 160 DDVDAAVINGNYALEAGLNPKKDALALEDKDnSPYANILVVRKGNEDDPRIKKLAKALQSDEVKDFIEEKYDGAVVP 236
|
|
| Lipoprotein_9 |
pfam03180 |
NlpA lipoprotein; This entry represents bacterial lipoproteins that belong to the NlpA family. ... |
39-275 |
3.29e-100 |
|
NlpA lipoprotein; This entry represents bacterial lipoproteins that belong to the NlpA family. It contains several antigenic members, that may be involved in bacterial virulence. This entry includes the D-methionine binding lipoprotein MetQ, which is the substrate-binding component of a D-methionine permease, a binding protein-dependent, ATP-driven transport system. Other members of this family, such as NlpA, have been identified as putative substrate-binding components of ABC transporters. NlpA, is an inner-membrane-anchored lipoprotein that has been shown to have a minor role in methionine import.
Pssm-ID: 427184 Cd Length: 236 Bit Score: 292.63 E-value: 3.29e-100
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502821327 39 LKVGAASTPHAEILKYVEPDLKKEGIKLDIVNIKDGIQTNEQTANGELDANYFQHTPYLKQTNKDSGLNLVNVTNVHIEP 118
Cdd:pfam03180 1 LKVGATPGPHAEILEVAKPLLKKKGLDLEIVEFTDYVQPNTALADGEIDANYFQHLPYLDQFNKEKGLDLVAVGNVHIEP 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502821327 119 FGVYSKKIKSIDDLSKGAKVAVPNDPVNFSRALELFQANGIIELnKKPSGSSYTVEDISKNKKKLDFVAVDGPLLVRSLD 198
Cdd:pfam03180 81 MGLYSKKYKSLSELPDGATIAVPNDPSNEGRALLLLQKAGLIKL-KDGKGLLATVKDITENPKNLKIKELEAAQLPRALD 159
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 502821327 199 DVEASAINTNYALEGGFKPTKDALIIEKKESPYVNILVTTKEKKDDKNIQRLAKALTTDKVKKFINDKYDGAVVPAF 275
Cdd:pfam03180 160 DVDAAVINTNYALEAGLNPKKDALFEEDKDSPYVNIIVVREDDKDDEAVKKLVEAYQSEEVKKFIEKKYGGAVIPAW 236
|
|
| TIGR00363 |
TIGR00363 |
lipoprotein, YaeC family; This family of putative lipoproteins contains a consensus site for ... |
27-275 |
4.37e-60 |
|
lipoprotein, YaeC family; This family of putative lipoproteins contains a consensus site for lipoprotein signal sequence cleavage. Included in this family is the E. coli hypothetical protein yaeC. About half of the proteins between the noise and trusted cutoffs contain the consensus lipoprotein signature and may belong to this family. [Cell envelope, Other]
Pssm-ID: 129460 Cd Length: 258 Bit Score: 191.27 E-value: 4.37e-60
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502821327 27 SGQNSDKKEDIVLKVGAASTPH---AEILKYVEPDlkKEGIKLDIVNIKDGIQTNEQTANGELDANYFQHTPYLKQTNKD 103
Cdd:TIGR00363 8 TGCKQDKKDPLHIKVGVISGAEqqvAEVAAKVAKE--KYGLDVELVEFNDYALPNEAVSKGDLDANAFQHKPYLDQDAKA 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502821327 104 SGLNLVNVTNVHIEPFGVYSKKIKSIDDLSKGAKVAVPNDPVNFSRALELFQANGIIELnKKPSGSSYTVEDISKNKKKL 183
Cdd:TIGR00363 86 KGYKLVAVGNTFVYPLAGYSKKIKNVNELQDGAKVAVPNDPTNLGRALLLLQKQGLIKL-KDGNGLLPTVLDIVENPKKL 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502821327 184 DFVAVDGPLLVRSLDD--VEASAINTNYALEGGFKPTKDALIIEKKESPYVNILVTTKEKKDDKNIQRLAKALTTDKVKK 261
Cdd:TIGR00363 165 NITELETSQLPRALDDpkVDLAVINTTYAGQVGLNPQDDGVFVEDKDSPYVNIIVSREDNKDAENVKDFIQSYQSEEVYQ 244
|
250
....*....|....
gi 502821327 262 FINDKYDGAVVPAF 275
Cdd:TIGR00363 245 AAQKHFNGGAVKGW 258
|
|
| metQ |
PRK11063 |
D-methionine ABC transporter substrate-binding protein MetQ; |
1-272 |
3.04e-59 |
|
D-methionine ABC transporter substrate-binding protein MetQ;
Pssm-ID: 182939 [Multi-domain] Cd Length: 271 Bit Score: 189.59 E-value: 3.04e-59
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502821327 1 MKKFVWLFALLAVITVVGgCGNKEKASGQnsdkkedivLKVGAASTPH---AEILKYVEPDlkKEGIKLDIVNIKDGIQT 77
Cdd:PRK11063 5 FKTFAAVGALIGTLALVG-CGQDEKDPNH---------IKVGVIVGAEqqvAEVAQKVAKE--KYGLDVELVTFNDYVLP 72
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502821327 78 NEQTANGELDANYFQHTPYLKQTNKDSGLNLVNVTNVHIEPFGVYSKKIKSIDDLSKGAKVAVPNDPVNFSRALELFQAN 157
Cdd:PRK11063 73 NEALSKGDIDANAFQHKPYLDQQIKDRGYKLVAVGNTFVYPIAGYSKKIKSLDELQDGSQVAVPNDPTNLGRSLLLLQKV 152
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502821327 158 GIIELnKKPSGSSYTVEDISKNKKKLDFVAVDGPLLVRSLDD--VEASAINTNYALEGGFKPTKDALIIEKKESPYVNIL 235
Cdd:PRK11063 153 GLIKL-KDGVGLLPTVLDIVENPKNLKIVELEAPQLPRSLDDaqIALAVINTTYASQIGLTPAKDGIFVEDKDSPYVNLI 231
|
250 260 270
....*....|....*....|....*....|....*..
gi 502821327 236 VTTKEKKDDKNIQRLAKALTTDKVKKFINDKYDGAVV 272
Cdd:PRK11063 232 VAREDNKDAENVKKFVQAYQSDEVYEAANKVFNGGAV 268
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| NlpA |
COG1464 |
ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion ... |
1-275 |
1.25e-127 |
|
ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism];
Pssm-ID: 441073 [Multi-domain] Cd Length: 270 Bit Score: 363.28 E-value: 1.25e-127
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502821327 1 MKKFVWLFALLAVITVVGGCGNKEKASGQNSDKkediVLKVGAASTPHAEILKYVEPDLKKEGIKLDIVNIKDGIQTNEQ 80
Cdd:COG1464 1 MKKLLALLLALALALALAACGSSSAAAAAADKK----TIKVGATPGPHAEILEVVKPELAKKGIDLEIVEFTDYVQPNEA 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502821327 81 TANGELDANYFQHTPYLKQTNKDSGLNLVNVTNVHIEPFGVYSKKIKSIDDLSKGAKVAVPNDPVNFSRALELFQANGII 160
Cdd:COG1464 77 LADGEIDANYFQHIPYLDNFNKENGYDLVPVGKTHIEPMGLYSKKYKSLDELPDGATIAIPNDPTNQGRALLLLQKAGLI 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502821327 161 ELnKKPSGSSYTVEDISKNKKKLDFVAVDGPLLVRSLDDVEASAINTNYALEGGFKPTKDALIIEKKESPYVNILVTTKE 240
Cdd:COG1464 157 KL-KDGVGLLATVKDITENPKNLKFVELDAAQLPRSLDDVDAAVINGNYALEAGLDPTKDALFLEDKDSPYANIIVVRED 235
|
250 260 270
....*....|....*....|....*....|....*
gi 502821327 241 KKDDKNIQRLAKALTTDKVKKFINDKYDGAVVPAF 275
Cdd:COG1464 236 DKDDPAIKKLVEAYQSDEVKKFIEEKYKGAVVPAW 270
|
|
| PBP2_lipoprotein_Tp32 |
cd13597 |
The substrate-binding domain of the 32-kilodalton lipoprotein (Tp32) from Treponema pallidum ... |
38-273 |
5.04e-109 |
|
The substrate-binding domain of the 32-kilodalton lipoprotein (Tp32) from Treponema pallidum binds L-methionine; the type 2 periplasmic-binding protein fold; This group includes the lipoprotein Tp32, a periplasmic component of a methionine uptake transporter system, and its closely related homologs. The Tp32 has both structural and sequential homology to the MetQ family of substrate-binding protein, and thus it belongs to the type 2 periplasmic binding fold protein superfamily (PBP2). The PBP2 proteins are typically comprised of two globular subdomains connected by a flexible hinge and bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap. The majority of PBP2 proteins function in the uptake of small soluble substrates in eubacteria and archaea.
Pssm-ID: 270315 Cd Length: 236 Bit Score: 314.98 E-value: 5.04e-109
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502821327 38 VLKVGAASTPHAEILKYVEPDLKKEGIKLDIVNIKDGIQTNEQTANGELDANYFQHTPYLKQTNKDSGLNLVNVTNVHIE 117
Cdd:cd13597 1 TLKVGATPVPHAEILEFIKPELKKQGIDLEIVEFTDYVQPNTALADGELDANYFQHVPYLESFNKEKGYDLVAVAGVHLE 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502821327 118 PFGVYSKKIKSIDDLSKGAKVAVPNDPVNFSRALELFQANGIIELnKKPSGSSYTVEDISKNKKKLDFVAVDGPLLVRSL 197
Cdd:cd13597 81 PMGLYSKKYKSLEDLPDGATIAIPNDPTNQGRALLLLEEAGLITL-KDGAGLTATVKDIVKNPKNLKFKELEAAQLPRSL 159
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 502821327 198 DDVEASAINTNYALEGGFKPTKDALIIEKKE-SPYVNILVTTKEKKDDKNIQRLAKALTTDKVKKFINDKYDGAVVP 273
Cdd:cd13597 160 DDVDAAVINGNYALEAGLNPKKDALALEDKDnSPYANILVVRKGNEDDPRIKKLAKALQSDEVKDFIEEKYDGAVVP 236
|
|
| Lipoprotein_9 |
pfam03180 |
NlpA lipoprotein; This entry represents bacterial lipoproteins that belong to the NlpA family. ... |
39-275 |
3.29e-100 |
|
NlpA lipoprotein; This entry represents bacterial lipoproteins that belong to the NlpA family. It contains several antigenic members, that may be involved in bacterial virulence. This entry includes the D-methionine binding lipoprotein MetQ, which is the substrate-binding component of a D-methionine permease, a binding protein-dependent, ATP-driven transport system. Other members of this family, such as NlpA, have been identified as putative substrate-binding components of ABC transporters. NlpA, is an inner-membrane-anchored lipoprotein that has been shown to have a minor role in methionine import.
Pssm-ID: 427184 Cd Length: 236 Bit Score: 292.63 E-value: 3.29e-100
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502821327 39 LKVGAASTPHAEILKYVEPDLKKEGIKLDIVNIKDGIQTNEQTANGELDANYFQHTPYLKQTNKDSGLNLVNVTNVHIEP 118
Cdd:pfam03180 1 LKVGATPGPHAEILEVAKPLLKKKGLDLEIVEFTDYVQPNTALADGEIDANYFQHLPYLDQFNKEKGLDLVAVGNVHIEP 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502821327 119 FGVYSKKIKSIDDLSKGAKVAVPNDPVNFSRALELFQANGIIELnKKPSGSSYTVEDISKNKKKLDFVAVDGPLLVRSLD 198
Cdd:pfam03180 81 MGLYSKKYKSLSELPDGATIAVPNDPSNEGRALLLLQKAGLIKL-KDGKGLLATVKDITENPKNLKIKELEAAQLPRALD 159
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 502821327 199 DVEASAINTNYALEGGFKPTKDALIIEKKESPYVNILVTTKEKKDDKNIQRLAKALTTDKVKKFINDKYDGAVVPAF 275
Cdd:pfam03180 160 DVDAAVINTNYALEAGLNPKKDALFEEDKDSPYVNIIVVREDDKDDEAVKKLVEAYQSEEVKKFIEKKYGGAVIPAW 236
|
|
| PBP2_lipoprotein_MetQ_like |
cd13526 |
The periplasmic-binding component of ABC-type methionine uptake transporter system and its ... |
38-264 |
2.47e-82 |
|
The periplasmic-binding component of ABC-type methionine uptake transporter system and its related lipoproteins; the type 2 periplasmic-binding protein fold; This family represents the periplasmic substrate-binding domain of ATP-binding cassette (ABC) transporter involved in uptake of methionine (MetQ) and its related homologs. Members of the MetQ-like family include the 32-kilodalton lipoprotein (Tp32) from Treponema pallidum, the membrane-associated lipoprotein-9 GmpC from Staphylococcus aureus, and Toll-like receptor 2-activating lipoprotein IlpA from Vibrio vulnificus. They all function as a receptor for methionine. This substrate-binding domain belongs to the type 2 periplasmic binding fold protein superfamily (PBP2). The PBP2 proteins are typically comprised of two globular subdomains connected by a flexible hinge and bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap. The majority of PBP2 proteins function in the uptake of small soluble substrates in eubacteria and archaea.
Pssm-ID: 270244 Cd Length: 228 Bit Score: 246.84 E-value: 2.47e-82
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502821327 38 VLKVGAASTPHAEILKYVEPDLKKEGIKLDIVNIKDGIQTNEQTANGELDANYFQHTPYLKQTNKDSGLNLVNVTNVHIE 117
Cdd:cd13526 1 KLKIGVTAGPSADVVEAAKKEAKKKGYELELVVFTDYVAPNEALNDGSIDANFFQHVPFLDQFNKERNGDLVKVGKTVIA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502821327 118 PFGVYSKKIKSIDDLSKGAKVAVPNDPVNFSRALELFQANGIIELnKKPSGSSYTVEDISKNKKKLDFVAVDGPLLVRSL 197
Cdd:cd13526 81 PIGLYSKKYKSLDELPDGARIAIPNDPSNGARALLLLEDAGLIKL-KDGVGLFATVLDITENPKNLEIVEVDAAQLPRSL 159
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 502821327 198 DDVEASAINTNYALEGGFKPTKDALIIEKKE-SPYVNILVTTKEKKDDKNIQRLAKALTTDKVKKFIN 264
Cdd:cd13526 160 DDVDAAVINGNYAISAGLDPRKDAIFLEDSDaSPYVNVLAVREDNKDDPWVKALVEAYQSEEVRKFLK 227
|
|
| PBP2_lipoprotein_IlpA_like |
cd13598 |
Toll-like receptor 2-activating lipoprotein IlpA from Vibrio vulnificus and similar ... |
39-264 |
1.36e-68 |
|
Toll-like receptor 2-activating lipoprotein IlpA from Vibrio vulnificus and similar lipoproteins; the type 2 periplasmic binding protein fold; This group includes the IlpA protein which has both structural and sequential homology to the MetQ family of substrate-binding protein, and thus belongs to the type 2 periplasmic binding fold protein superfamily (PBP2). The PBP2 proteins are typically comprised of two globular subdomains connected by a flexible hinge and bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap. The majority of PBP2 proteins function in the uptake of small soluble substrates in eubacteria and archaea.
Pssm-ID: 270316 Cd Length: 227 Bit Score: 211.82 E-value: 1.36e-68
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502821327 39 LKVGAASTPHAEILKYVEPDLKKEGIKLDIVNIKDGIQTNEQTANGELDANYFQHTPYLKQTNKDSGLNLVNVTNVHIEP 118
Cdd:cd13598 2 IKVGVIRGPDAQIWEVVQKVAKEKGLDVELVTFNDYAQPNEALAAGDLDANAFQHKPYLDAQIKARGYKLVIVGNTFVYP 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502821327 119 FGVYSKKIKSIDDLSKGAKVAVPNDPVNFSRALELFQANGIIELnKKPSGSSYTVEDISKNKKKLDFVAVDGPLLVRSLD 198
Cdd:cd13598 82 IGLYSKKIKSLAELPNGATVAIPNDPSNEGRALLLLQKEGLIKL-KDGVGLLATVRDIAENPKKLKIVELDAGQLPRALD 160
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 502821327 199 DVEASAINTNYALEGGFKPTKDALIIEKKESPYVNILVTTKEKKDDKNIQRLAKALTTDKVKKFIN 264
Cdd:cd13598 161 DVDLAAINTDYASKAGLTPARDAIAQEDKRSPYANVIAVREDDKDAPWVKTLVQAYQSEEVKAFAL 226
|
|
| PBP2_lipoprotein_like_1 |
cd13600 |
Putative periplasmic-binding component of ABC-type methionine uptake transporter system-like; ... |
38-263 |
5.06e-65 |
|
Putative periplasmic-binding component of ABC-type methionine uptake transporter system-like; the type 2 periplasmic binding protein fold; This subgroup shares significant sequence homology with the periplasmic substrate-binding domain of ATP-binding cassette (ABC) transporter involved in uptake of methionine (MetQ). The members of the MetQ-like family include the 32-kilodalton lipoprotein (Tp32) from Treponema pallidum, the membrane-associated lipoprotein-9 GmpC from Staphylococcus aureus, and Toll-like receptor 2-activating lipoprotein IlpA from Vibrio vulnificus. They all function as a receptor for methionine. This substrate-binding domain belongs to the type 2 periplasmic binding fold protein superfamily (PBP2). The PBP2 proteins are typically comprised of two globular subdomains connected by a flexible hinge and bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap. The majority of PBP2 proteins function in the uptake of small soluble substrates in eubacteria and archaea.
Pssm-ID: 270318 Cd Length: 228 Bit Score: 202.95 E-value: 5.06e-65
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502821327 38 VLKVGAASTPHAEILKYVEPDLKKEGIKLDIVNIKDGIQTNEQTANGELDANYFQHTPYLKQTNKDSGLNLVNVTNVHIE 117
Cdd:cd13600 1 TLKVATNSGPMTEILEYIAAELAPDGITIEPVQVSDYVQANRAVAAGEIDANFFQHQPFMEQFNEANGFELVAVQPIYHW 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502821327 118 PFGVYSKKIKSIDDLSKGAKVAVPNDPVNFSRALELFQANGIIELNKKPSGSSYTVEDISKNKKKLDFVAVDGPLLVRSL 197
Cdd:cd13600 81 AFGFYSKKYKSVEDLPDGAKVAIPNDPANQARALLLLQRAGLITLKPGVDPTTATLADIVTNPKNLKFTEVDLLALPRAL 160
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 502821327 198 DDVEASAINTNYALEGGFKPTKDALIIEKKESPYVNILVTTKEKKDDKNIQRLAKALTTDKVKKFI 263
Cdd:cd13600 161 DDVDLAFGYPSYFDAAGLTPKDGILLEEPDAKRFAIQLVAREDNKDSPKIKKLKEAFTDPRVRKFL 226
|
|
| TIGR00363 |
TIGR00363 |
lipoprotein, YaeC family; This family of putative lipoproteins contains a consensus site for ... |
27-275 |
4.37e-60 |
|
lipoprotein, YaeC family; This family of putative lipoproteins contains a consensus site for lipoprotein signal sequence cleavage. Included in this family is the E. coli hypothetical protein yaeC. About half of the proteins between the noise and trusted cutoffs contain the consensus lipoprotein signature and may belong to this family. [Cell envelope, Other]
Pssm-ID: 129460 Cd Length: 258 Bit Score: 191.27 E-value: 4.37e-60
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502821327 27 SGQNSDKKEDIVLKVGAASTPH---AEILKYVEPDlkKEGIKLDIVNIKDGIQTNEQTANGELDANYFQHTPYLKQTNKD 103
Cdd:TIGR00363 8 TGCKQDKKDPLHIKVGVISGAEqqvAEVAAKVAKE--KYGLDVELVEFNDYALPNEAVSKGDLDANAFQHKPYLDQDAKA 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502821327 104 SGLNLVNVTNVHIEPFGVYSKKIKSIDDLSKGAKVAVPNDPVNFSRALELFQANGIIELnKKPSGSSYTVEDISKNKKKL 183
Cdd:TIGR00363 86 KGYKLVAVGNTFVYPLAGYSKKIKNVNELQDGAKVAVPNDPTNLGRALLLLQKQGLIKL-KDGNGLLPTVLDIVENPKKL 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502821327 184 DFVAVDGPLLVRSLDD--VEASAINTNYALEGGFKPTKDALIIEKKESPYVNILVTTKEKKDDKNIQRLAKALTTDKVKK 261
Cdd:TIGR00363 165 NITELETSQLPRALDDpkVDLAVINTTYAGQVGLNPQDDGVFVEDKDSPYVNIIVSREDNKDAENVKDFIQSYQSEEVYQ 244
|
250
....*....|....
gi 502821327 262 FINDKYDGAVVPAF 275
Cdd:TIGR00363 245 AAQKHFNGGAVKGW 258
|
|
| metQ |
PRK11063 |
D-methionine ABC transporter substrate-binding protein MetQ; |
1-272 |
3.04e-59 |
|
D-methionine ABC transporter substrate-binding protein MetQ;
Pssm-ID: 182939 [Multi-domain] Cd Length: 271 Bit Score: 189.59 E-value: 3.04e-59
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502821327 1 MKKFVWLFALLAVITVVGgCGNKEKASGQnsdkkedivLKVGAASTPH---AEILKYVEPDlkKEGIKLDIVNIKDGIQT 77
Cdd:PRK11063 5 FKTFAAVGALIGTLALVG-CGQDEKDPNH---------IKVGVIVGAEqqvAEVAQKVAKE--KYGLDVELVTFNDYVLP 72
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502821327 78 NEQTANGELDANYFQHTPYLKQTNKDSGLNLVNVTNVHIEPFGVYSKKIKSIDDLSKGAKVAVPNDPVNFSRALELFQAN 157
Cdd:PRK11063 73 NEALSKGDIDANAFQHKPYLDQQIKDRGYKLVAVGNTFVYPIAGYSKKIKSLDELQDGSQVAVPNDPTNLGRSLLLLQKV 152
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502821327 158 GIIELnKKPSGSSYTVEDISKNKKKLDFVAVDGPLLVRSLDD--VEASAINTNYALEGGFKPTKDALIIEKKESPYVNIL 235
Cdd:PRK11063 153 GLIKL-KDGVGLLPTVLDIVENPKNLKIVELEAPQLPRSLDDaqIALAVINTTYASQIGLTPAKDGIFVEDKDSPYVNLI 231
|
250 260 270
....*....|....*....|....*....|....*..
gi 502821327 236 VTTKEKKDDKNIQRLAKALTTDKVKKFINDKYDGAVV 272
Cdd:PRK11063 232 VAREDNKDAENVKKFVQAYQSDEVYEAANKVFNGGAV 268
|
|
| PBP2_lipoprotein_GmpC |
cd13596 |
The periplasmic substrate-binding domain of the membrane-associated lipoprotein-9 GmpC; ... |
38-264 |
8.64e-59 |
|
The periplasmic substrate-binding domain of the membrane-associated lipoprotein-9 GmpC; contains the type 2 periplasmic-binding protein fold; This group includes the membrane-associated lipoprotein-9 from Staphylococcus aureus that binds the dipeptide glycylmethionine (GlyMet). The lipoprotein-9 has both structural and sequential homology to the MetQ family of substrate-binding protein. The GlyMet binding protein belongs to the type 2 periplasmic binding fold protein superfamily (PBP2). The PBP2 proteins are typically comprised of two globular subdomains connected by a flexible hinge and bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap. The majority of PBP2 proteins function in the uptake of small soluble substrates in eubacteria and archaea.
Pssm-ID: 270314 Cd Length: 230 Bit Score: 186.80 E-value: 8.64e-59
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502821327 38 VLKVGAASTpHAEILKYVEPDLKKEGIKLDIVNIKDGIQTNEQTANGELDANYFQHTPYLKQTNKDSGLNLVNVTNVHIE 117
Cdd:cd13596 1 TVKIGVTGE-DTDIWDKIVEEAEEAGIKLELVNFSDYSQPNKALNDGDIDLNAFQHYAYLVQYNSKNNADLTAIGDTVIA 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502821327 118 PFGVYSKKIKSIDDLSKGAKVAVPNDPVNFSRALELFQANGIIELnKKPSGSSYTVEDISKNKKKLDFVAVDGPLLVRSL 197
Cdd:cd13596 80 PMGIYSKKITSVDELPDGAKIAIPNDPSNLSRALFILQAAGLIKL-KKDAGDFPTVNDITENPKNLEIVPVDADQVYRAL 158
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 502821327 198 DDVEASAINTNYALEGGFKPTKDALIIEKKES----PYVNILVTTKEKKDDKNIQRLAKALTTDKVKKFIN 264
Cdd:cd13596 159 NDVDAAVINNTFALDAGLDPKKDAIFLEDPSSygskPYINLIAVREEDKDNPLYKKLVETYHDERVQKAVE 229
|
|
| PBP2_lipoprotein_Gna1946 |
cd13599 |
The membrane-associated lipoprotein Gna1946 from Neisseria meningitidis; the type 2 ... |
38-265 |
7.00e-58 |
|
The membrane-associated lipoprotein Gna1946 from Neisseria meningitidis; the type 2 periplasmic binding protein fold; Gna1946 shares significant structural and sequence homology with the periplasmic substrate-binding domain of ATP-binding cassette (ABC) transporter involved in uptake of methionine (MetQ). The members of the MetQ-like family include the 32-kilodalton lipoprotein (Tp32) from Treponema pallidum, the membrane-associated lipoprotein-9 GmpC from Staphylococcus aureus, and Toll-like receptor 2-activating lipoprotein IlpA from Vibrio vulnificus. They all function as a receptor for methionine. This substrate-binding domain belongs to the type 2 periplasmic binding fold protein superfamily (PBP2). The PBP2 proteins are typically comprised of two globular subdomains connected by a flexible hinge and bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap. The majority of PBP2 proteins function in the uptake of small soluble substrates in eubacteria and archaea.
Pssm-ID: 270317 Cd Length: 228 Bit Score: 184.52 E-value: 7.00e-58
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502821327 38 VLKVGAASTPHAEILKY-VEPDLKKEGIKLDIVNIKDGIQTNEQTANGELDANYFQHTPYLKQTNKDSGLNLVNVTNVHI 116
Cdd:cd13599 1 TIVIGFTPGPYGDMVKNgVAPYLEKKGYEVKLKEFTDYVQPNNALANGEIDANVFQHKPYLDAFNKENGLDLVGIVQVPT 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502821327 117 EPFGVYSKKIKSIDDLSKGAKVAVPNDPVNFSRALELFQANGIIELNKKPSGSSYTVEDISKNKKKLDFVAVDGPLLVRS 196
Cdd:cd13599 81 PPMGLYSNKHKSLEEVKDGATVAIPNDPSNLARALVMLQDLGWITLKDNIDPLKASVNDIAENPKNIKIVELEAAQLPRS 160
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 502821327 197 LDDVEASAINTNYALEGGFKPTkDALIIEKKESPYVNILVTTKEKKDDKNIQRLAKALTTDKVKKFIND 265
Cdd:cd13599 161 LDDVDFAAIQGNFAISSGIKLT-SALALEEMTDPYVNVVAVKTADKDKQFAKDVTAAYNSDAFKAYIHA 228
|
|
| PRK09861 |
PRK09861 |
lipoprotein NlpA; |
9-275 |
3.24e-57 |
|
lipoprotein NlpA;
Pssm-ID: 182119 Cd Length: 272 Bit Score: 184.45 E-value: 3.24e-57
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502821327 9 ALLAVITVVGGCGNkekasgQNSDKKEDIVLKVGAASTPHAEILKYVEPDlkKEGIKLDIVNIKDGIQTNEQTANGELDA 88
Cdd:PRK09861 13 ALLLAGILLAGCDQ------SSSDAKHIKVGVINGAEQDVAEVAKKVAKE--KYGLDVELVGFSGSLLPNDATNHGELDA 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502821327 89 NYFQHTPYLKQTNKDSGLNLVNVTNVHIEPFGVYSKKIKSIDDLSKGAKVAVPNDPVNFSRALELFQANGIIELnKKPSG 168
Cdd:PRK09861 85 NVFQHRPFLEQDNQAHGYKLVAVGNTFVFPMAGYSKKIKTVAQIKEGATVAIPNDPTNLGRALLLLQKEKLITL-KEGKG 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502821327 169 SSYTVEDISKNKKKLDFVAVDGPLLVRSLDD--VEASAINTNYALEGGFKPTKDALIIEKKESPYVNILVTTKEKKDDKN 246
Cdd:PRK09861 164 LLPTALDITDNPRHLQIMELEGAQLPRVLDDpkVDVAIISTTYIQQTGLSPVHDSVFIEDKNSPYVNILVAREDNKNAEN 243
|
250 260
....*....|....*....|....*....
gi 502821327 247 IQRLAKALTTDKVKKFINDKYDGAVVPAF 275
Cdd:PRK09861 244 VKEFLQSYQSPEVAKAAETIFNGGAVPGW 272
|
|
| TauA |
COG0715 |
ABC-type nitrate/sulfonate/bicarbonate transport system, periplasmic component [Inorganic ion ... |
9-271 |
1.12e-08 |
|
ABC-type nitrate/sulfonate/bicarbonate transport system, periplasmic component [Inorganic ion transport and metabolism];
Pssm-ID: 440479 [Multi-domain] Cd Length: 297 Bit Score: 55.01 E-value: 1.12e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502821327 9 ALLAVITVVGGCGnkekasgQNSDKKEDIVLKVG-AASTPHAEIlkYVEPD---LKKEGIKLDIVNIKDGIQTNEQTANG 84
Cdd:COG0715 1 LAALAALALAACS-------AAAAAAEKVTLRLGwLPNTDHAPL--YVAKEkgyFKKEGLDVELVEFAGGAAALEALAAG 71
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502821327 85 ELDANYFQHTPYLKQTNKdsGLNLVNVTNVHI-EPFGVYSKK---IKSIDDLsKGAKVAVPNDPVNFSRALELFQANGIi 160
Cdd:COG0715 72 QADFGVAGAPPALAARAK--GAPVKAVAALSQsGGNALVVRKdsgIKSLADL-KGKKVAVPGGSTSHYLLRALLAKAGL- 147
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502821327 161 elnkkpsgssytvediskNKKKLDFVAVDGPLLVRSL--DDVEASAINTNYA----LEGGFK---PTKDALiiekkESPY 231
Cdd:COG0715 148 ------------------DPKDVEIVNLPPPDAVAALlaGQVDAAVVWEPFEsqaeKKGGGRvlaDSADLV-----PGYP 204
|
250 260 270 280
....*....|....*....|....*....|....*....|..
gi 502821327 232 VNILVTTKE--KKDDKNIQRLAKALTtdKVKKFINDKYDGAV 271
Cdd:COG0715 205 GDVLVASEDflEENPEAVKAFLRALL--KAWAWAAANPDEAA 244
|
|
| NMT1 |
pfam09084 |
NMT1/THI5 like; This family contains the NMT1 and THI5 proteins. These proteins are proposed ... |
54-159 |
3.00e-03 |
|
NMT1/THI5 like; This family contains the NMT1 and THI5 proteins. These proteins are proposed to be required for the biosynthesis of the pyrimidine moiety of thiamine.3]. They are regulated by thiamine. The protein adopts a fold related to the periplasmic binding protein (PBP) family. Both pyridoxal-5'-phosphate (PLP) and an iron atom are bound to the protein suggesting numerous residues of the active site necessary for HMP-P biosynthesis. The yeast protein is a dimer and, although exceptionally using PLP as a substrate, has notable similarities with enzymes dependent on this molecule as a cofactor.
Pssm-ID: 430398 [Multi-domain] Cd Length: 216 Bit Score: 37.97 E-value: 3.00e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502821327 54 YVEPDL---KKEGIKLDIVNIKDGIQTNEQTANGELD-ANYFQhtPYLKQTnKDSGLNLVNVTNV-HIEPFGVYSKK--- 125
Cdd:pfam09084 8 YVAQEKgyfKEEGLDVEIVEPADPSDATQLVASGKADfGVSYQ--ESVLLA-RAKGLPVVSVAALiQHPLSGVISLKdsg 84
|
90 100 110
....*....|....*....|....*....|....
gi 502821327 126 IKSIDDLsKGAKVAVPNDPVNFSRALELFQANGI 159
Cdd:pfam09084 85 IKSPKDL-KGKRIGYSGSPFEEALLKALLKKDGG 117
|
|
| PBP2_sulfate_ester_like |
cd13555 |
Sulfate ester binding protein-like, the type 2 periplasmic binding protein fold; This ... |
53-161 |
4.63e-03 |
|
Sulfate ester binding protein-like, the type 2 periplasmic binding protein fold; This subfamily includes the periplasmic component of putative ABC-type sulfonate transport system similar to SsuA. These domains are found in eubacterial SsuA proteins that serve as initial receptors in the ABC transport of bicarbonate, nitrate, taurine, or a wide range of aliphatic sulfonates, while other closest homologs are involved in thiamine (vitamin B1) biosynthetic pathway and desulfurization (DszB). After binding the ligand, SsuA interacts with a cognate membrane transport complex comprised of two integral membrane domains and two cytoplasmically located ATPase domains. This interaction triggers the ligand translocation across the cytoplasmic membrane energized by ATP hydrolysis. The SsuA proteins belong to the PBP2 superfamily of periplasmic binding proteins that differ in size and ligand specificity, but have similar tertiary structures consisting of two globular subdomains connected by a flexible hinge. They have been shown to bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap.
Pssm-ID: 270273 Cd Length: 268 Bit Score: 37.70 E-value: 4.63e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502821327 53 KYVEPDLKKEGIKLDIVNIKD-GIQTNEQTANGELDANYFQHTPYLkqTNKDSGLN--LVNVTNvhiEPFGVY-----SK 124
Cdd:cd13555 28 GWLEEEFAKDGIKVEWVFFKGaGPAVNEAFANGQIDFAVYGDLPAI--IGRAAGLDtkLLLSSG---SGNNAYlvvppDS 102
|
90 100 110 120
....*....|....*....|....*....|....*....|
gi 502821327 125 KIKSIDDLsKGAKVAV---PNDPVNFSRALElfqANGIIE 161
Cdd:cd13555 103 TIKSVKDL-KGKKVAVqkgTAWQLTFLRILA---KNGLSE 138
|
|
| |
