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Conserved domains on  [gi|502826397|ref|WP_013061373|]
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MULTISPECIES: orotate phosphoribosyltransferase [Salinibacter]

Protein Classification

orotate phosphoribosyltransferase( domain architecture ID 10785483)

orotate phosphoribosyltransferase catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)

CATH:  3.40.50.2020
EC:  2.4.2.-
Gene Ontology:  GO:0046132|GO:0004588|GO:0000287
PubMed:  11751055
SCOP:  4000253

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PyrE COG0461
Orotate phosphoribosyltransferase [Nucleotide transport and metabolism]; Orotate ...
 11-190 9.56e-26

Orotate phosphoribosyltransferase [Nucleotide transport and metabolism]; Orotate phosphoribosyltransferase is part of the Pathway/BioSystem: Pyrimidine biosynthesis


:

Pssm-ID: 440229  Cd Length: 201  Bit Score: 98.30  E-value: 9.56e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502826397  11 SSSRAELIEIgrkLYE-EALVRREdelITDPRGQPIGWLLDTRVPTLDGELFTEVGSVIAERLRERG--ARQVVGYGFGA 87
Cdd:COG0461    1 MSYKEELAEL---LLEiGALLFGH---FTLSSGRHSPYYIDCRLVLSYPEALELLGEALAELIKELGpeFDAVAGPATGG 74

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502826397  88 HPLVCSVLAVSEgdeFKGGLIREERKEHGRRRLVEGPIDADQPVVMVDDIINSGRSASEALRLVRSAGFAVDGLLTLFNF 167
Cdd:COG0461   75 IPLAAAVARALG---LPAIFVRKEAKDHGTGGQIEGGLLPGERVLVVEDVITTGGSVLEAVEALREAGAEVVGVAVIVDR 151

                        170       180
                 ....*....|....*....|...
gi 502826397 168 TwSNGQDRIEAEGLWVDSLLDLN 190
Cdd:COG0461  152 E-EGAAENLEEAGVPLHSLLTLD 173
 
Name Accession Description Interval E-value
PyrE COG0461
Orotate phosphoribosyltransferase [Nucleotide transport and metabolism]; Orotate ...
 11-190 9.56e-26

Orotate phosphoribosyltransferase [Nucleotide transport and metabolism]; Orotate phosphoribosyltransferase is part of the Pathway/BioSystem: Pyrimidine biosynthesis


Pssm-ID: 440229  Cd Length: 201  Bit Score: 98.30  E-value: 9.56e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502826397  11 SSSRAELIEIgrkLYE-EALVRREdelITDPRGQPIGWLLDTRVPTLDGELFTEVGSVIAERLRERG--ARQVVGYGFGA 87
Cdd:COG0461    1 MSYKEELAEL---LLEiGALLFGH---FTLSSGRHSPYYIDCRLVLSYPEALELLGEALAELIKELGpeFDAVAGPATGG 74

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502826397  88 HPLVCSVLAVSEgdeFKGGLIREERKEHGRRRLVEGPIDADQPVVMVDDIINSGRSASEALRLVRSAGFAVDGLLTLFNF 167
Cdd:COG0461   75 IPLAAAVARALG---LPAIFVRKEAKDHGTGGQIEGGLLPGERVLVVEDVITTGGSVLEAVEALREAGAEVVGVAVIVDR 151

                        170       180
                 ....*....|....*....|...
gi 502826397 168 TwSNGQDRIEAEGLWVDSLLDLN 190
Cdd:COG0461  152 E-EGAAENLEEAGVPLHSLLTLD 173
pyrE PRK00455
orotate phosphoribosyltransferase; Validated
 49-190 2.09e-14

orotate phosphoribosyltransferase; Validated


Pssm-ID: 234771  Cd Length: 202  Bit Score: 68.64  E-value: 2.09e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502826397  49 LDTRVPTLDGELFTEVGSVIAERLRERGARQ--VVGYGFGAHPLVCsvlAVSEGDEFKGGLIREERKEHGRRRLVEGPID 126
Cdd:PRK00455  35 FDCRKLLSYPEALALLGRFLAEAIKDSGIEFdvVAGPATGGIPLAA---AVARALDLPAIFVRKEAKDHGEGGQIEGRRL 111

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 502826397 127 ADQPVVMVDDIINSGRSASEALRLVRSAGFAVDGLLTLFNFTwSNGQDRIEAEGLWVDSLLDLN 190
Cdd:PRK00455 112 FGKRVLVVEDVITTGGSVLEAVEAIRAAGAEVVGVAVIVDRQ-SAAQEVFADAGVPLISLITLD 174
PRTases_typeI cd06223
Phosphoribosyl transferase (PRT)-type I domain; Phosphoribosyl transferase (PRT) domain. The ...
 64-165 4.47e-08

Phosphoribosyl transferase (PRT)-type I domain; Phosphoribosyl transferase (PRT) domain. The type I PRTases are identified by a conserved PRPP binding motif which features two adjacent acidic residues surrounded by one or more hydrophobic residue. PRTases catalyze the displacement of the alpha-1'-pyrophosphate of 5-phosphoribosyl-alpha1-pyrophosphate (PRPP) by a nitrogen-containing nucleophile. The reaction products are an alpha-1 substituted ribose-5'-phosphate and a free pyrophosphate (PP). PRPP, an activated form of ribose-5-phosphate, is a key metabolite connecting nucleotide synthesis and salvage pathways. The type I PRTase family includes a range of diverse phosphoribosyl transferase enzymes and regulatory proteins of the nucleotide synthesis and salvage pathways, including adenine phosphoribosyltransferase EC:2.4.2.7., hypoxanthine-guanine-xanthine phosphoribosyltransferase, hypoxanthine phosphoribosyltransferase EC:2.4.2.8., ribose-phosphate pyrophosphokinase EC:2.7.6.1., amidophosphoribosyltransferase EC:2.4.2.14., orotate phosphoribosyltransferase EC:2.4.2.10., uracil phosphoribosyltransferase EC:2.4.2.9., and xanthine-guanine phosphoribosyltransferase EC:2.4.2.22.


Pssm-ID: 206754 [Multi-domain]  Cd Length: 130  Bit Score: 49.70  E-value: 4.47e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502826397  64 VGSVIAERLRERGARQVV-------GYGFGAhpLVCSVLAVsegdefKGGLIREERKEHGRRR-------LVEGPIDADQ 129
Cdd:cd06223    1 AGRLLAEEIREDLLEPDVvvgilrgGLPLAA--ALARALGL------PLAFIRKERKGPGRTPsepygleLPLGGDVKGK 72

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 502826397 130 PVVMVDDIINSGRSASEALRLVRSAGFAVDGLLTLF 165
Cdd:cd06223   73 RVLLVDDVIATGGTLLAAIELLKEAGAKVVGVAVLL 108
 
Name Accession Description Interval E-value
PyrE COG0461
Orotate phosphoribosyltransferase [Nucleotide transport and metabolism]; Orotate ...
 11-190 9.56e-26

Orotate phosphoribosyltransferase [Nucleotide transport and metabolism]; Orotate phosphoribosyltransferase is part of the Pathway/BioSystem: Pyrimidine biosynthesis


Pssm-ID: 440229  Cd Length: 201  Bit Score: 98.30  E-value: 9.56e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502826397  11 SSSRAELIEIgrkLYE-EALVRREdelITDPRGQPIGWLLDTRVPTLDGELFTEVGSVIAERLRERG--ARQVVGYGFGA 87
Cdd:COG0461    1 MSYKEELAEL---LLEiGALLFGH---FTLSSGRHSPYYIDCRLVLSYPEALELLGEALAELIKELGpeFDAVAGPATGG 74

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502826397  88 HPLVCSVLAVSEgdeFKGGLIREERKEHGRRRLVEGPIDADQPVVMVDDIINSGRSASEALRLVRSAGFAVDGLLTLFNF 167
Cdd:COG0461   75 IPLAAAVARALG---LPAIFVRKEAKDHGTGGQIEGGLLPGERVLVVEDVITTGGSVLEAVEALREAGAEVVGVAVIVDR 151

                        170       180
                 ....*....|....*....|...
gi 502826397 168 TwSNGQDRIEAEGLWVDSLLDLN 190
Cdd:COG0461  152 E-EGAAENLEEAGVPLHSLLTLD 173
pyrE PRK00455
orotate phosphoribosyltransferase; Validated
 49-190 2.09e-14

orotate phosphoribosyltransferase; Validated


Pssm-ID: 234771  Cd Length: 202  Bit Score: 68.64  E-value: 2.09e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502826397  49 LDTRVPTLDGELFTEVGSVIAERLRERGARQ--VVGYGFGAHPLVCsvlAVSEGDEFKGGLIREERKEHGRRRLVEGPID 126
Cdd:PRK00455  35 FDCRKLLSYPEALALLGRFLAEAIKDSGIEFdvVAGPATGGIPLAA---AVARALDLPAIFVRKEAKDHGEGGQIEGRRL 111

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 502826397 127 ADQPVVMVDDIINSGRSASEALRLVRSAGFAVDGLLTLFNFTwSNGQDRIEAEGLWVDSLLDLN 190
Cdd:PRK00455 112 FGKRVLVVEDVITTGGSVLEAVEAIRAAGAEVVGVAVIVDRQ-SAAQEVFADAGVPLISLITLD 174
PRK05500 PRK05500
bifunctional orotidine-5'-phosphate decarboxylase/orotate phosphoribosyltransferase;
109-189 8.49e-09

bifunctional orotidine-5'-phosphate decarboxylase/orotate phosphoribosyltransferase;


Pssm-ID: 180119 [Multi-domain]  Cd Length: 477  Bit Score: 54.30  E-value: 8.49e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502826397 109 REERKEHGRRRLVEGPIDADQPVVMVDDIINSGRSASEALRLVRSAGFAVDGLLTLFNFTwSNGQDRIEAEGLWVDSLLD 188
Cdd:PRK05500 374 RKEVKAHGTRRLIEGNFHPGETVVVVDDILITGKSVMEGAEKLKSAGLNVRDIVVFIDHE-QGVKDKLQSHGYQAYSVLT 452


                 .
gi 502826397 189 L 189
Cdd:PRK05500 453 I 453
PRTases_typeI cd06223
Phosphoribosyl transferase (PRT)-type I domain; Phosphoribosyl transferase (PRT) domain. The ...
 64-165 4.47e-08

Phosphoribosyl transferase (PRT)-type I domain; Phosphoribosyl transferase (PRT) domain. The type I PRTases are identified by a conserved PRPP binding motif which features two adjacent acidic residues surrounded by one or more hydrophobic residue. PRTases catalyze the displacement of the alpha-1'-pyrophosphate of 5-phosphoribosyl-alpha1-pyrophosphate (PRPP) by a nitrogen-containing nucleophile. The reaction products are an alpha-1 substituted ribose-5'-phosphate and a free pyrophosphate (PP). PRPP, an activated form of ribose-5-phosphate, is a key metabolite connecting nucleotide synthesis and salvage pathways. The type I PRTase family includes a range of diverse phosphoribosyl transferase enzymes and regulatory proteins of the nucleotide synthesis and salvage pathways, including adenine phosphoribosyltransferase EC:2.4.2.7., hypoxanthine-guanine-xanthine phosphoribosyltransferase, hypoxanthine phosphoribosyltransferase EC:2.4.2.8., ribose-phosphate pyrophosphokinase EC:2.7.6.1., amidophosphoribosyltransferase EC:2.4.2.14., orotate phosphoribosyltransferase EC:2.4.2.10., uracil phosphoribosyltransferase EC:2.4.2.9., and xanthine-guanine phosphoribosyltransferase EC:2.4.2.22.


Pssm-ID: 206754 [Multi-domain]  Cd Length: 130  Bit Score: 49.70  E-value: 4.47e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502826397  64 VGSVIAERLRERGARQVV-------GYGFGAhpLVCSVLAVsegdefKGGLIREERKEHGRRR-------LVEGPIDADQ 129
Cdd:cd06223    1 AGRLLAEEIREDLLEPDVvvgilrgGLPLAA--ALARALGL------PLAFIRKERKGPGRTPsepygleLPLGGDVKGK 72

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 502826397 130 PVVMVDDIINSGRSASEALRLVRSAGFAVDGLLTLF 165
Cdd:cd06223   73 RVLLVDDVIATGGTLLAAIELLKEAGAKVVGVAVLL 108
Apt COG0503
Adenine/guanine phosphoribosyltransferase or related PRPP-binding protein [Nucleotide ...
 57-189 1.08e-04

Adenine/guanine phosphoribosyltransferase or related PRPP-binding protein [Nucleotide transport and metabolism]; Adenine/guanine phosphoribosyltransferase or related PRPP-binding protein is part of the Pathway/BioSystem: Purine salvage


Pssm-ID: 440269  Cd Length: 171  Bit Score: 41.21  E-value: 1.08e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502826397  57 DGELFTEVGSVIAERLRERGARQVVGY---GFG-AHPLvcsvlavseGDEFKGGLI--REERK------------EHGRR 118
Cdd:COG0503   29 DPELFRAAGDELAERFADKGIDKVVGIearGFIlAAAL---------AYALGVPFVpaRKPGKlpgetvseeydlEYGTG 99

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 502826397 119 RLVEGPIDADQP---VVMVDDIINSGRSASEALRLVRSAGFAVDGLLTLFNFTWSNGQDRIEAEGlwVDSLLDL 189
Cdd:COG0503  100 DTLELHKDALKPgdrVLIVDDLLATGGTAKAAIKLVEEAGAEVVGIAFLIELGFLGGREKLRDYP--VESLLTL 171
PRK07199 PRK07199
ribose-phosphate diphosphokinase;
127-157 3.31e-04

ribose-phosphate diphosphokinase;


Pssm-ID: 235960 [Multi-domain]  Cd Length: 301  Bit Score: 40.31  E-value: 3.31e-04
                         10        20        30
                 ....*....|....*....|....*....|.
gi 502826397 127 ADQPVVMVDDIINSGRSASEALRLVRSAGFA 157
Cdd:PRK07199 210 AGRTPVLVDDIVSTGRTLIEAARQLRAAGAA 240
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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