|
Name |
Accession |
Description |
Interval |
E-value |
| PRK08006 |
PRK08006 |
replicative DNA helicase DnaB; |
1-470 |
0e+00 |
|
replicative DNA helicase DnaB;
Pssm-ID: 181193 [Multi-domain] Cd Length: 471 Bit Score: 946.36 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502860087 1 MAGNKPFNK-QTEPRERDFQVAGLKVPPHSIEAEQSVLGGLMLDNERWDDVAERVVSDDFYTRPHRHIFTEMARLQESGS 79
Cdd:PRK08006 1 MAGNKPFNKqQAEPRERDPQVAGLKVPPHSIEAEQSVLGGLMLDNERWDDVAERVVADDFYTRPHRHIFTEMARLQESGS 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502860087 80 PIDLITLAESLERQGQLDSVGGFAYLAELSKNTPSAANISAYADIVRERAVVREMISVANEIAEAGFDPQGRTSEDLLDL 159
Cdd:PRK08006 81 PIDLITLAESLERQGQLDSVGGFAYLAELSKNTPSAANISAYADIVRERAVVREMISVANEIADAGYDPQGRTSEDLLDL 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502860087 160 AESRVFKIAESRANKDEGPKNIADVLDATVARIEQLFQQPHDGVTGVNTGYDDLNKKTAGLQPSDLIIVAARPSMGKTTF 239
Cdd:PRK08006 161 AESRVFQIAESRANKDEGPKNIADILDATVARIEQLFQQPHDGVTGVNTGYDDLNKKTAGLQPSDLIIVAARPSMGKTTF 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502860087 240 AMNLVENAAMLQDKPVLIFSLEMPSEQIMMRSLASLSRVDQTRIRTGQLDDEDWARISGTMGILLEKRNIYIDDSSGLTP 319
Cdd:PRK08006 241 AMNLCENAAMLQDKPVLIFSLEMPGEQIMMRMLASLSRVDQTRIRTGQLDDEDWARISGTMGILLEKRNMYIDDSSGLTP 320
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502860087 320 TEVRSRARRIAREHGGIGLIMIDYLQLMRVPSLSDNRTLEIAEISRSLKALAKELHVPVVALSQLNRSLEQRADKRPVNS 399
Cdd:PRK08006 321 TEVRSRARRIFREHGGLSLIMIDYLQLMRVPSLSDNRTLEIAEISRSLKALAKELQVPVVALSQLNRSLEQRADKRPVNS 400
|
410 420 430 440 450 460 470
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 502860087 400 DLRESGSIEQDADLIMFIYRDEVYHENSDLKGIAEIIIGKQRNGPIGTVRLTFNGQWSRFDNYAGPQYDDE 470
Cdd:PRK08006 401 DLRESGSIEQDADLIMFIYRDEVYHENSDLKGIAEIIIGKQRNGPIGTVRLTFNGQWSRFDNYAGPQYDDE 471
|
|
| DnaB |
TIGR00665 |
replicative DNA helicase; This model describes the helicase DnaB, a homohexameric protein ... |
26-463 |
0e+00 |
|
replicative DNA helicase; This model describes the helicase DnaB, a homohexameric protein required for DNA replication. The homohexamer can form a ring around a single strand of DNA near a replication fork. An intein of > 400 residues is found at a conserved location in DnaB of Synechocystis PCC6803, Rhodothermus marinus (both experimentally confirmed), and Mycobacterium tuberculosis. The intein removes itself by a self-splicing reaction. The seed alignment contains inteins so that the model built from the seed alignment will model a low cost at common intein insertion sites. [DNA metabolism, DNA replication, recombination, and repair]
Pssm-ID: 273206 [Multi-domain] Cd Length: 432 Bit Score: 750.41 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502860087 26 PPHSIEAEQSVLGGLMLDNERWDDVAERVVSDDFYTRPHRHIFTEMARLQESGSPIDLITLAESLERQGQLDSVGGFAYL 105
Cdd:TIGR00665 1 PPHNIEAEQAVLGAILLDNEAIDDVAEILKPEDFYRPAHRLIFQAILDLYEKGEPIDLVTVAEELEKDGELEEVGGLAYL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502860087 106 AELSKNTPSAANISAYADIVRERAVVREMISVANEIAEAGFDPQGrTSEDLLDLAESRVFKIAESRanKDEGPKNIADVL 185
Cdd:TIGR00665 81 AELASNVPSAANIEYYAEIVKEKAILRRLIQAGTEIVELAYDPTG-DVEELLDEAEQKIFEIAESR--TSKGFKSIKEIL 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502860087 186 DATVARIEQLFQQPhDGVTGVNTGYDDLNKKTAGLQPSDLIIVAARPSMGKTTFAMNLVENAAMLQDKPVLIFSLEMPSE 265
Cdd:TIGR00665 158 KEAVEEIEELYERK-GGITGVPTGFTDLDKLTSGLQPSDLIILAARPSMGKTAFALNIAENAAIKEGKPVAFFSLEMSAE 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502860087 266 QIMMRSLASLSRVDQTRIRTGQLDDEDWARISGTMGILLEKrNIYIDDSSGLTPTEVRSRARRIAREHGgIGLIMIDYLQ 345
Cdd:TIGR00665 237 QLVMRMLSSESRVDSQKLRTGRLSDEDWEKLTEAAGELSEA-PLYIDDTPGLTITELRAKARRLKREHG-LGLIVIDYLQ 314
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502860087 346 LMRVPSLSDNRTLEIAEISRSLKALAKELHVPVVALSQLNRSLEQRADKRPVNSDLRESGSIEQDADLIMFIYRDEVYHE 425
Cdd:TIGR00665 315 LMSGSGRSENRQQEVSEISRSLKALAKELNVPVIALSQLSRSVEQREDKRPQLSDLRESGSIEQDADIVMFLYRDEYYNP 394
|
410 420 430
....*....|....*....|....*....|....*...
gi 502860087 426 NSDLKGIAEIIIGKQRNGPIGTVRLTFNGQWSRFDNYA 463
Cdd:TIGR00665 395 DSEDKGIAEIIIAKQRNGPTGTVKLAFLGEYTRFENLA 432
|
|
| DnaB |
COG0305 |
Replicative DNA helicase [Replication, recombination and repair]; |
29-463 |
0e+00 |
|
Replicative DNA helicase [Replication, recombination and repair];
Pssm-ID: 440074 [Multi-domain] Cd Length: 429 Bit Score: 723.40 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502860087 29 SIEAEQSVLGGLMLDNERWDDVAERVVSDDFYTRPHRHIFTEMARLQESGSPIDLITLAESLERQGQLDSVGGFAYLAEL 108
Cdd:COG0305 1 NIEAEQAVLGALLLDNDALDEVADILKPEDFYRPAHRLIFEAILDLYERGEPIDLVTVAEELEKRGELEEVGGAAYLAEL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502860087 109 SKNTPSAANISAYADIVRERAVVREMISVANEIAEAGFDPQgRTSEDLLDLAESRVFKIAESRANKdeGPKNIADVLDAT 188
Cdd:COG0305 81 AENVPSAANIEYYARIVKEKALLRRLIEAGTEIVELAYDED-EDVDELLDEAEQKIFEIAEKRSSK--GFVSISDILKEA 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502860087 189 VARIEQLFQQPhDGVTGVNTGYDDLNKKTAGLQPSDLIIVAARPSMGKTTFAMNLVENAAMLQDKPVLIFSLEMPSEQIM 268
Cdd:COG0305 158 LERIEELYKNG-GGITGVPTGFTDLDKLTGGLQPGDLIILAARPSMGKTAFALNIARNAAIKEGKPVAIFSLEMSAEQLV 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502860087 269 MRSLASLSRVDQTRIRTGQLDDEDWARISGTMGILlEKRNIYIDDSSGLTPTEVRSRARRIAREHGgIGLIMIDYLQLMR 348
Cdd:COG0305 237 MRLLSSEARIDSSKLRTGKLSDEDWERLSSAAGEL-SEAPIYIDDTPGLTIAEIRAKARRLKREHG-LGLIVIDYLQLMS 314
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502860087 349 VPSLSDNRTLEIAEISRSLKALAKELHVPVVALSQLNRSLEQRADKRPVNSDLRESGSIEQDADLIMFIYRDEVYHENSD 428
Cdd:COG0305 315 GSGRSENRQQEISEISRSLKALAKELNVPVIALSQLSRAVEQRTDKRPQLSDLRESGSIEQDADVVMFLYRDEYYNPDSE 394
|
410 420 430
....*....|....*....|....*....|....*
gi 502860087 429 LKGIAEIIIGKQRNGPIGTVRLTFNGQWSRFDNYA 463
Cdd:COG0305 395 DKGIAEIIIAKQRNGPTGTVKLAFDGEYTRFENLA 429
|
|
| dnaB_SPI-7_type |
NF040583 |
SPI-7-type island replicative DNA helicase; Members of this family are DnaB-PI, a ... |
26-462 |
0e+00 |
|
SPI-7-type island replicative DNA helicase; Members of this family are DnaB-PI, a pathogenicity island (PI) variant of the replicative DNA helicase DnaB. Members are found with other conjugative element replication proteins such as ParA, ParB in genetic islands whose core proteins (but not cargo proteins) are shared with the Salmonella typhi SPI-7 island.
Pssm-ID: 468557 [Multi-domain] Cd Length: 434 Bit Score: 659.01 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502860087 26 PPHSIEAEQSVLGGLMLDNERWDDVAERVVSDDFYTRPHRHIFTEMARLQESGSPIDLITLAESLERQGQLDSVGGFAYL 105
Cdd:NF040583 1 GPYSVEAEQSVLGGLMLDNDRWDDVALLLAADDFYSRAHRIIFRAMARLVSAGQPIDLITLSESLEQQGQLEQVGGFAYL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502860087 106 AELSKNTPSAANISAYADIVRERAVVREMISVANEIAEAGFDPQGRTSeDLLDLAESRVFKIAESRAnkDEGPKNIADVL 185
Cdd:NF040583 81 AELSKNTPSAANIVAYAEIVAEYSRARQLLALGHDLSADASAPRADIA-DLLEQAEQRLFDIAEQAE--PQQEVTLIEGL 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502860087 186 DATVARIEQLFQQPhDGVTGVNTGYDDLNKKTAGLQPSDLIIVAARPSMGKTTFAMNLVENAAM-LQDKPVLIFSLEMPS 264
Cdd:NF040583 158 ETLVSELELRCQSG-NGITGTPTGFAELDEMTCGLQPGDLILLAARPSMGKTALALAFCLGALRgKPDKVVQIYSLEMPT 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502860087 265 EQIMMRSLASLSRVDQTRIRTGQLDDEDWARISGTMGILLEKRN-IYIDDSSGLTPTEVRSRARRIAREHGGIGLIMIDY 343
Cdd:NF040583 237 EQLLMRLVSMLGRVPLQRLRSGLLDDEDWARISQAMALLTDWKDrLIIDDTSYLTPALLRARARRNARKYGKPSLIMVDY 316
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502860087 344 LQLMRVPSlSDNRTLEIAEISRSLKALAKELHVPVVALSQLNRSLEQRADKRPVNSDLRESGSIEQDADLIMFIYRDEVY 423
Cdd:NF040583 317 LQLMRCPG-QENRTQEIAEISRSLKALAKEMGCPVLALSQLNRQLESRADKRPNNGDLRDSGALEQDADLIMFIYRDEVY 395
|
410 420 430
....*....|....*....|....*....|....*....
gi 502860087 424 HENSDLKGIAEIIIGKQRNGPIGTVRLTFNGQWSRFDNY 462
Cdd:NF040583 396 NPNTPDKGIAEIIIGKQRQGPTGTVKVQFDGRYTRFSDL 434
|
|
| DnaB_C |
pfam03796 |
DnaB-like helicase C terminal domain; The hexameric helicase DnaB unwinds the DNA duplex at ... |
205-461 |
1.90e-164 |
|
DnaB-like helicase C terminal domain; The hexameric helicase DnaB unwinds the DNA duplex at the Escherichia coli chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a change in the quaternary structure of the protein involving dimerization of the N-terminal domain has been observed and may occur during the enzymatic cycle. This C-terminal domain contains an ATP-binding site and is therefore probably the site of ATP hydrolysis.
Pssm-ID: 427509 [Multi-domain] Cd Length: 254 Bit Score: 463.81 E-value: 1.90e-164
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502860087 205 GVNTGYDDLNKKTAGLQPSDLIIVAARPSMGKTTFAMNLVENAAMLQDKPVLIFSLEMPSEQIMMRSLASLSRVDQTRIR 284
Cdd:pfam03796 1 GLPTGFTDLDRLTGGLQPGDLIIIAARPSMGKTAFALNIARNAAVKHKKPVAIFSLEMSAEQLVMRLLASEAGVDSQKLR 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502860087 285 TGQLDDEDWARISGTMGILlEKRNIYIDDSSGLTPTEVRSRARRIAREHGgIGLIMIDYLQLMRVPSLSDNRTLEIAEIS 364
Cdd:pfam03796 81 TGQLTDEDWEKLAKAAGRL-SEAPLYIDDTPGLSIAEIRAKARRLKREHG-LGLIVIDYLQLMSGGSRGENRQQEISEIS 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502860087 365 RSLKALAKELHVPVVALSQLNRSLEQRADKRPVNSDLRESGSIEQDADLIMFIYRDEVYHEnSDLKGIAEIIIGKQRNGP 444
Cdd:pfam03796 159 RSLKALAKELNVPVIALSQLSRAVEQRTDKRPQLSDLRESGAIEQDADVVMFLYRDEYYNP-KEPEGKAEIIIAKQRNGP 237
|
250
....*....|....*..
gi 502860087 445 IGTVRLTFNGQWSRFDN 461
Cdd:pfam03796 238 TGTVKLAFLGEYTRFEN 254
|
|
| DnaB_C |
cd00984 |
C-terminal domain of DnaB helicase; DnaB helicase C-terminal domain. The hexameric helicase ... |
205-461 |
1.01e-157 |
|
C-terminal domain of DnaB helicase; DnaB helicase C-terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a change in the quaternary structure of the protein involving dimerization of the N-terminal domain has been observed and may occur during the enzymatic cycle. This C-terminal domain contains an ATP-binding site and is therefore probably the site of ATP hydrolysis.
Pssm-ID: 410864 [Multi-domain] Cd Length: 256 Bit Score: 446.96 E-value: 1.01e-157
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502860087 205 GVNTGYDDLNKKTAGLQPSDLIIVAARPSMGKTTFAMNLVENAAMLQDKPVLIFSLEMPSEQIMMRSLASLSRVDQTRIR 284
Cdd:cd00984 1 GLPTGFTDLDKLTGGLQPGDLIIIAARPSMGKTAFALNIAENIALDEGLPVLFFSLEMSAEQLAERLLSSESGVSLSKLR 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502860087 285 TGQLDDEDWARISGTMGILLEKrNIYIDDSSGLTPTEVRSRARRIAREHGGIGLIMIDYLQLMRVPSLSDNRTLEIAEIS 364
Cdd:cd00984 81 TGRLDDEDWERLTAAMGELSEL-PLYIDDTPGLTVDEIRAKARRLKREHGGLGLIVIDYLQLIRGSKRAENRQQEVAEIS 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502860087 365 RSLKALAKELHVPVVALSQLNRSLEQRADKRPVNSDLRESGSIEQDADLIMFIYRDEVYHENSDLKGIAEIIIGKQRNGP 444
Cdd:cd00984 160 RSLKALAKELNVPVIALSQLNRGVESRTDKRPMLSDLRESGSIEQDADVVIFLYRDEYYDKDSEDKGIAEIIIAKNRNGP 239
|
250
....*....|....*..
gi 502860087 445 IGTVRLTFNGQWSRFDN 461
Cdd:cd00984 240 TGTVYLAFNPEYTRFTD 256
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| PRK08006 |
PRK08006 |
replicative DNA helicase DnaB; |
1-470 |
0e+00 |
|
replicative DNA helicase DnaB;
Pssm-ID: 181193 [Multi-domain] Cd Length: 471 Bit Score: 946.36 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502860087 1 MAGNKPFNK-QTEPRERDFQVAGLKVPPHSIEAEQSVLGGLMLDNERWDDVAERVVSDDFYTRPHRHIFTEMARLQESGS 79
Cdd:PRK08006 1 MAGNKPFNKqQAEPRERDPQVAGLKVPPHSIEAEQSVLGGLMLDNERWDDVAERVVADDFYTRPHRHIFTEMARLQESGS 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502860087 80 PIDLITLAESLERQGQLDSVGGFAYLAELSKNTPSAANISAYADIVRERAVVREMISVANEIAEAGFDPQGRTSEDLLDL 159
Cdd:PRK08006 81 PIDLITLAESLERQGQLDSVGGFAYLAELSKNTPSAANISAYADIVRERAVVREMISVANEIADAGYDPQGRTSEDLLDL 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502860087 160 AESRVFKIAESRANKDEGPKNIADVLDATVARIEQLFQQPHDGVTGVNTGYDDLNKKTAGLQPSDLIIVAARPSMGKTTF 239
Cdd:PRK08006 161 AESRVFQIAESRANKDEGPKNIADILDATVARIEQLFQQPHDGVTGVNTGYDDLNKKTAGLQPSDLIIVAARPSMGKTTF 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502860087 240 AMNLVENAAMLQDKPVLIFSLEMPSEQIMMRSLASLSRVDQTRIRTGQLDDEDWARISGTMGILLEKRNIYIDDSSGLTP 319
Cdd:PRK08006 241 AMNLCENAAMLQDKPVLIFSLEMPGEQIMMRMLASLSRVDQTRIRTGQLDDEDWARISGTMGILLEKRNMYIDDSSGLTP 320
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502860087 320 TEVRSRARRIAREHGGIGLIMIDYLQLMRVPSLSDNRTLEIAEISRSLKALAKELHVPVVALSQLNRSLEQRADKRPVNS 399
Cdd:PRK08006 321 TEVRSRARRIFREHGGLSLIMIDYLQLMRVPSLSDNRTLEIAEISRSLKALAKELQVPVVALSQLNRSLEQRADKRPVNS 400
|
410 420 430 440 450 460 470
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 502860087 400 DLRESGSIEQDADLIMFIYRDEVYHENSDLKGIAEIIIGKQRNGPIGTVRLTFNGQWSRFDNYAGPQYDDE 470
Cdd:PRK08006 401 DLRESGSIEQDADLIMFIYRDEVYHENSDLKGIAEIIIGKQRNGPIGTVRLTFNGQWSRFDNYAGPQYDDE 471
|
|
| PRK08840 |
PRK08840 |
replicative DNA helicase; Provisional |
13-470 |
0e+00 |
|
replicative DNA helicase; Provisional
Pssm-ID: 181562 [Multi-domain] Cd Length: 464 Bit Score: 826.16 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502860087 13 PRERDFQVAGLKVPPHSIEAEQSVLGGLMLDNERWDDVAERVVSDDFYTRPHRHIFTEMARLQESGSPIDLITLAESLER 92
Cdd:PRK08840 7 RKIPDAQVDAIKVPPHSLEAEQSVIGGLLLDNERWDTVAEKVVASDFYSRPHRLIFEGVKSILEAGKPLDLITLSEHLER 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502860087 93 QGQLDSVGGFAYLAELSKNTPSAANISAYADIVRERAVVREMISVANEIAEAGFDPQGRTSEDLLDLAESRVFKIAESRA 172
Cdd:PRK08840 87 REQLEDVGGFAYLADLAKNTPSAANINAYADIVAERALVRNLIGVANEIADAGYDPQGRTSEDLLDMAESKVFAIAEART 166
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502860087 173 NKDEGPKNIADVLDATVARIEQLFQQPHDGVTGVNTGYDDLNKKTAGLQPSDLIIVAARPSMGKTTFAMNLVENAAMLQD 252
Cdd:PRK08840 167 SENEGPQNVDSILEKTLERIELLYKTPQDGVTGVDTGFTDLNKKTAGLQGSDLIIVAARPSMGKTTFAMNLCENAAMDQD 246
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502860087 253 KPVLIFSLEMPSEQIMMRSLASLSRVDQTRIRTGQLDDEDWARISGTMGILLEKRNIYIDDSSGLTPTEVRSRARRIARE 332
Cdd:PRK08840 247 KPVLIFSLEMPAEQLMMRMLASLSRVDQTKIRTGQLDDEDWARISSTMGILMEKKNMYIDDSSGLTPTEVRSRARRIARE 326
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502860087 333 HGGIGLIMIDYLQLMRVPSLSDNRTLEIAEISRSLKALAKELHVPVVALSQLNRSLEQRADKRPVNSDLRESGSIEQDAD 412
Cdd:PRK08840 327 HGGLSMIMVDYLQLMRVPALSDNRTLEIAEISRSLKALAKELNVPVVALSQLNRSLEQRADKRPVNSDLRESGSIEQDAD 406
|
410 420 430 440 450
....*....|....*....|....*....|....*....|....*....|....*...
gi 502860087 413 LIMFIYRDEVYHENSDLKGIAEIIIGKQRNGPIGTVRLTFNGQWSRFDNYAGPQYDDE 470
Cdd:PRK08840 407 LIMFIYRDEVYNPDSPLKGTAEIIIGKQRNGPIGSVRLTFQGQYSRFDNYAGPAFDDE 464
|
|
| DnaB |
TIGR00665 |
replicative DNA helicase; This model describes the helicase DnaB, a homohexameric protein ... |
26-463 |
0e+00 |
|
replicative DNA helicase; This model describes the helicase DnaB, a homohexameric protein required for DNA replication. The homohexamer can form a ring around a single strand of DNA near a replication fork. An intein of > 400 residues is found at a conserved location in DnaB of Synechocystis PCC6803, Rhodothermus marinus (both experimentally confirmed), and Mycobacterium tuberculosis. The intein removes itself by a self-splicing reaction. The seed alignment contains inteins so that the model built from the seed alignment will model a low cost at common intein insertion sites. [DNA metabolism, DNA replication, recombination, and repair]
Pssm-ID: 273206 [Multi-domain] Cd Length: 432 Bit Score: 750.41 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502860087 26 PPHSIEAEQSVLGGLMLDNERWDDVAERVVSDDFYTRPHRHIFTEMARLQESGSPIDLITLAESLERQGQLDSVGGFAYL 105
Cdd:TIGR00665 1 PPHNIEAEQAVLGAILLDNEAIDDVAEILKPEDFYRPAHRLIFQAILDLYEKGEPIDLVTVAEELEKDGELEEVGGLAYL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502860087 106 AELSKNTPSAANISAYADIVRERAVVREMISVANEIAEAGFDPQGrTSEDLLDLAESRVFKIAESRanKDEGPKNIADVL 185
Cdd:TIGR00665 81 AELASNVPSAANIEYYAEIVKEKAILRRLIQAGTEIVELAYDPTG-DVEELLDEAEQKIFEIAESR--TSKGFKSIKEIL 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502860087 186 DATVARIEQLFQQPhDGVTGVNTGYDDLNKKTAGLQPSDLIIVAARPSMGKTTFAMNLVENAAMLQDKPVLIFSLEMPSE 265
Cdd:TIGR00665 158 KEAVEEIEELYERK-GGITGVPTGFTDLDKLTSGLQPSDLIILAARPSMGKTAFALNIAENAAIKEGKPVAFFSLEMSAE 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502860087 266 QIMMRSLASLSRVDQTRIRTGQLDDEDWARISGTMGILLEKrNIYIDDSSGLTPTEVRSRARRIAREHGgIGLIMIDYLQ 345
Cdd:TIGR00665 237 QLVMRMLSSESRVDSQKLRTGRLSDEDWEKLTEAAGELSEA-PLYIDDTPGLTITELRAKARRLKREHG-LGLIVIDYLQ 314
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502860087 346 LMRVPSLSDNRTLEIAEISRSLKALAKELHVPVVALSQLNRSLEQRADKRPVNSDLRESGSIEQDADLIMFIYRDEVYHE 425
Cdd:TIGR00665 315 LMSGSGRSENRQQEVSEISRSLKALAKELNVPVIALSQLSRSVEQREDKRPQLSDLRESGSIEQDADIVMFLYRDEYYNP 394
|
410 420 430
....*....|....*....|....*....|....*...
gi 502860087 426 NSDLKGIAEIIIGKQRNGPIGTVRLTFNGQWSRFDNYA 463
Cdd:TIGR00665 395 DSEDKGIAEIIIAKQRNGPTGTVKLAFLGEYTRFENLA 432
|
|
| PRK06904 |
PRK06904 |
replicative DNA helicase; Validated |
6-470 |
0e+00 |
|
replicative DNA helicase; Validated
Pssm-ID: 136106 [Multi-domain] Cd Length: 472 Bit Score: 737.96 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502860087 6 PFNKQTEPRERDFQVAGLKVPPHSIEAEQSVLGGLMLDNERWDDVAERVVSDDFYTRPHRHIFTEMARLQESGSPIDLIT 85
Cdd:PRK06904 3 TTGSQQSARIKDKKTAQVLIPPHSIEAEQAVLGGIMLDNRHWDSVAERVIADDFYTFEHRIIFQEMELLFRQNTPIDLLT 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502860087 86 LAESLERQGQLDSVGGFAYLAELSKNTPSAANISAYADIVRERAVVREMISVANEIAEAGFDPQGRTSEDLLDLAESRVF 165
Cdd:PRK06904 83 LDQALKTKGKSDEVGGFAYLAELSNNTPSAANILAYADIVREKAILRELISVGNNIAKNAYSPKGQDIKDILDEAERDVF 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502860087 166 KIAESRANKDEGPKNIADVLDATVARIEQLFQQP-HDGVTGVNTGYDDLNKKTAGLQPSDLIIVAARPSMGKTTFAMNLV 244
Cdd:PRK06904 163 SIAEKRTTANEGPQNVINLLENTIDKIENLAATPtNNGVTGVTTGFTDLDKKTAGLQPSDLIIVAARPSMGKTTFAMNLC 242
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502860087 245 ENAAMLQDKPVLIFSLEMPSEQIMMRSLASLSRVDQTRIRTGQ-LDDEDWARISGTMGILLEKRNIYIDDSSGLTPTEVR 323
Cdd:PRK06904 243 ENAAMASEKPVLVFSLEMPAEQIMMRMLASLSRVDQTKIRTGQnLDQQDWAKISSTVGMFKQKPNLYIDDSSGLTPTELR 322
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502860087 324 SRARRIAREHGGIGLIMIDYLQLMRVPSLSDNRTLEIAEISRSLKALAKELHVPVVALSQLNRSLEQRADKRPVNSDLRE 403
Cdd:PRK06904 323 SRARRVYRENGGLSLIMVDYLQLMRAPGFEDNRTLEIAEISRSLKALAKELKVPVVALSQLNRTLENRGDKRPVNSDLRE 402
|
410 420 430 440 450 460
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 502860087 404 SGSIEQDADLIMFIYRDEVYHENS-DLKGIAEIIIGKQRNGPIGTVRLTFNGQWSRFDNYAG-PQYDDE 470
Cdd:PRK06904 403 SGSIEQDADLIMFIYRDEVYNETTeDNKGVAEIIIGKQRNGPIGRVRLAFQGQYSRFDNLANiPQYYDK 471
|
|
| DnaB |
COG0305 |
Replicative DNA helicase [Replication, recombination and repair]; |
29-463 |
0e+00 |
|
Replicative DNA helicase [Replication, recombination and repair];
Pssm-ID: 440074 [Multi-domain] Cd Length: 429 Bit Score: 723.40 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502860087 29 SIEAEQSVLGGLMLDNERWDDVAERVVSDDFYTRPHRHIFTEMARLQESGSPIDLITLAESLERQGQLDSVGGFAYLAEL 108
Cdd:COG0305 1 NIEAEQAVLGALLLDNDALDEVADILKPEDFYRPAHRLIFEAILDLYERGEPIDLVTVAEELEKRGELEEVGGAAYLAEL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502860087 109 SKNTPSAANISAYADIVRERAVVREMISVANEIAEAGFDPQgRTSEDLLDLAESRVFKIAESRANKdeGPKNIADVLDAT 188
Cdd:COG0305 81 AENVPSAANIEYYARIVKEKALLRRLIEAGTEIVELAYDED-EDVDELLDEAEQKIFEIAEKRSSK--GFVSISDILKEA 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502860087 189 VARIEQLFQQPhDGVTGVNTGYDDLNKKTAGLQPSDLIIVAARPSMGKTTFAMNLVENAAMLQDKPVLIFSLEMPSEQIM 268
Cdd:COG0305 158 LERIEELYKNG-GGITGVPTGFTDLDKLTGGLQPGDLIILAARPSMGKTAFALNIARNAAIKEGKPVAIFSLEMSAEQLV 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502860087 269 MRSLASLSRVDQTRIRTGQLDDEDWARISGTMGILlEKRNIYIDDSSGLTPTEVRSRARRIAREHGgIGLIMIDYLQLMR 348
Cdd:COG0305 237 MRLLSSEARIDSSKLRTGKLSDEDWERLSSAAGEL-SEAPIYIDDTPGLTIAEIRAKARRLKREHG-LGLIVIDYLQLMS 314
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502860087 349 VPSLSDNRTLEIAEISRSLKALAKELHVPVVALSQLNRSLEQRADKRPVNSDLRESGSIEQDADLIMFIYRDEVYHENSD 428
Cdd:COG0305 315 GSGRSENRQQEISEISRSLKALAKELNVPVIALSQLSRAVEQRTDKRPQLSDLRESGSIEQDADVVMFLYRDEYYNPDSE 394
|
410 420 430
....*....|....*....|....*....|....*
gi 502860087 429 LKGIAEIIIGKQRNGPIGTVRLTFNGQWSRFDNYA 463
Cdd:COG0305 395 DKGIAEIIIAKQRNGPTGTVKLAFDGEYTRFENLA 429
|
|
| PRK05748 |
PRK05748 |
replicative DNA helicase; Provisional |
17-468 |
0e+00 |
|
replicative DNA helicase; Provisional
Pssm-ID: 180232 [Multi-domain] Cd Length: 448 Bit Score: 690.54 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502860087 17 DFQVAGLKVPPHSIEAEQSVLGGLMLDNERWDDVAERVVSDDFYTRPHRHIFTEMARLQESGSPIDLITLAESLERQGQL 96
Cdd:PRK05748 1 MSEVAALRVPPQSIEAEQAVLGAIFLDPDALITVSEYLSPDDFYRHAHRLIFRAMLKLSDRGEPIDVVTVTEILDDQGDL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502860087 97 DSVGGFAYLAELSKNTPSAANISAYADIVRERAVVREMISVANEIAEAGFDPQGrTSEDLLDLAESRVFKIAESRANKde 176
Cdd:PRK05748 81 EEVGGLSYLAELANSVPTAANIEYYAKIVAEKAMLRRLIRTATEIANDAYEPED-DADEILDEAEKKIFEVSERRNKS-- 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502860087 177 GPKNIADVLDATVARIEQLFQQPHDgVTGVNTGYDDLNKKTAGLQPSDLIIVAARPSMGKTTFAMNLVENAAMLQDKPVL 256
Cdd:PRK05748 158 GFKNIKDVLVKAYDRIEMLHNQTGD-ITGIPTGFTDLDKMTSGLQPNDLIIVAARPSVGKTAFALNIAQNVATKTDKNVA 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502860087 257 IFSLEMPSEQIMMRSLASLSRVDQTRIRTGQLDDEDWARISGTMGiLLEKRNIYIDDSSGLTPTEVRSRARRIAREHGGI 336
Cdd:PRK05748 237 IFSLEMGAESLVMRMLCAEGNIDAQRLRTGQLTDDDWPKLTIAMG-SLSDAPIYIDDTPGIKVTEIRARCRRLAQEHGGL 315
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502860087 337 GLIMIDYLQLMRVP-SLSDNRTLEIAEISRSLKALAKELHVPVVALSQLNRSLEQRADKRPVNSDLRESGSIEQDADLIM 415
Cdd:PRK05748 316 GLILIDYLQLIQGSgRSGENRQQEVSEISRSLKALAKELKVPVIALSQLSRGVEQRQDKRPVMSDIRESGSIEQDADIVA 395
|
410 420 430 440 450
....*....|....*....|....*....|....*....|....*....|...
gi 502860087 416 FIYRDEVYHENSDLKGIAEIIIGKQRNGPIGTVRLTFNGQWSRFDNYAGPQYD 468
Cdd:PRK05748 396 FLYRDDYYDEETENKNTIEIIIAKQRNGPVGTVELAFQKEYNKFVNLARREED 448
|
|
| dnaB_SPI-7_type |
NF040583 |
SPI-7-type island replicative DNA helicase; Members of this family are DnaB-PI, a ... |
26-462 |
0e+00 |
|
SPI-7-type island replicative DNA helicase; Members of this family are DnaB-PI, a pathogenicity island (PI) variant of the replicative DNA helicase DnaB. Members are found with other conjugative element replication proteins such as ParA, ParB in genetic islands whose core proteins (but not cargo proteins) are shared with the Salmonella typhi SPI-7 island.
Pssm-ID: 468557 [Multi-domain] Cd Length: 434 Bit Score: 659.01 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502860087 26 PPHSIEAEQSVLGGLMLDNERWDDVAERVVSDDFYTRPHRHIFTEMARLQESGSPIDLITLAESLERQGQLDSVGGFAYL 105
Cdd:NF040583 1 GPYSVEAEQSVLGGLMLDNDRWDDVALLLAADDFYSRAHRIIFRAMARLVSAGQPIDLITLSESLEQQGQLEQVGGFAYL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502860087 106 AELSKNTPSAANISAYADIVRERAVVREMISVANEIAEAGFDPQGRTSeDLLDLAESRVFKIAESRAnkDEGPKNIADVL 185
Cdd:NF040583 81 AELSKNTPSAANIVAYAEIVAEYSRARQLLALGHDLSADASAPRADIA-DLLEQAEQRLFDIAEQAE--PQQEVTLIEGL 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502860087 186 DATVARIEQLFQQPhDGVTGVNTGYDDLNKKTAGLQPSDLIIVAARPSMGKTTFAMNLVENAAM-LQDKPVLIFSLEMPS 264
Cdd:NF040583 158 ETLVSELELRCQSG-NGITGTPTGFAELDEMTCGLQPGDLILLAARPSMGKTALALAFCLGALRgKPDKVVQIYSLEMPT 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502860087 265 EQIMMRSLASLSRVDQTRIRTGQLDDEDWARISGTMGILLEKRN-IYIDDSSGLTPTEVRSRARRIAREHGGIGLIMIDY 343
Cdd:NF040583 237 EQLLMRLVSMLGRVPLQRLRSGLLDDEDWARISQAMALLTDWKDrLIIDDTSYLTPALLRARARRNARKYGKPSLIMVDY 316
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502860087 344 LQLMRVPSlSDNRTLEIAEISRSLKALAKELHVPVVALSQLNRSLEQRADKRPVNSDLRESGSIEQDADLIMFIYRDEVY 423
Cdd:NF040583 317 LQLMRCPG-QENRTQEIAEISRSLKALAKEMGCPVLALSQLNRQLESRADKRPNNGDLRDSGALEQDADLIMFIYRDEVY 395
|
410 420 430
....*....|....*....|....*....|....*....
gi 502860087 424 HENSDLKGIAEIIIGKQRNGPIGTVRLTFNGQWSRFDNY 462
Cdd:NF040583 396 NPNTPDKGIAEIIIGKQRQGPTGTVKVQFDGRYTRFSDL 434
|
|
| PRK07004 |
PRK07004 |
replicative DNA helicase; Provisional |
15-469 |
0e+00 |
|
replicative DNA helicase; Provisional
Pssm-ID: 235907 [Multi-domain] Cd Length: 460 Bit Score: 566.46 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502860087 15 ERDFQVAGLKVPPHSIEAEQSVLGGLMLDNERWDDVAERVVSDDFYTRPHRHIFTEMARLQESGSPIDLITLAESLERQG 94
Cdd:PRK07004 4 PADPQLESLKVPPHSIEAEQSVLGGLLLDNAAWDRIADFLSQSDFYRYDHRIIFEHIGRLIAATRPADVITVYEALTTSG 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502860087 95 QLDSVGGFAYLAELSKNTPSAANISAYADIVRERAVVREMISVANEIAEAGFDPQGRTSEDLLDLAESRVFKIAESRANK 174
Cdd:PRK07004 84 KAEEVGGLAYLNALAQNTPSAANIRRYAEIVRDRAVLRRLVSVADEISADAFNPQGKEVRQLLDEAESKVFSIAEEGARG 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502860087 175 DEGPKNIADVLDATVARIEQLFQQPHDG-VTGVNTGYDDLNKKTAGLQPSDLIIVAARPSMGKTTFAMNLVENAAMLQDK 253
Cdd:PRK07004 164 TQGFLEIGPLLTQVVERIDTLYHTANPSdVTGTPTGFVDLDRMTSGMHGGELIIVAGRPSMGKTAFSMNIGEYVAVEYGL 243
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502860087 254 PVLIFSLEMPSEQIMMRSLASLSRVDQTRIRTGQLDDEDWARISGTMGiLLEKRNIYIDDSSGLTPTEVRSRARRIAREH 333
Cdd:PRK07004 244 PVAVFSMEMPGTQLAMRMLGSVGRLDQHRMRTGRLTDEDWPKLTHAVQ-KMSEAQLFIDETGGLNPMELRSRARRLARQC 322
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502860087 334 GGIGLIMIDYLQLMRVPSLSDNRTLEIAEISRSLKALAKELHVPVVALSQLNRSLEQRADKRPVNSDLRESGSIEQDADL 413
Cdd:PRK07004 323 GKLGLIIIDYLQLMSGSSQGENRATEISEISRSLKSLAKELDVPVIALSQLNRGLEQRPNKRPVMSDLRESGAIEQDADV 402
|
410 420 430 440 450
....*....|....*....|....*....|....*....|....*....|....*..
gi 502860087 414 IMFIYRDEVYHENSDLKGIAEIIIGKQRNGPIGTVRLTFNGQWSRFDNYAG-PQYDD 469
Cdd:PRK07004 403 ILFIYRDEVYNPDSPDKGTAEIIIGKQRNGPIGPVRLTFLGQYTKFDNFAGaQNFYG 459
|
|
| PRK08760 |
PRK08760 |
replicative DNA helicase; Provisional |
3-463 |
0e+00 |
|
replicative DNA helicase; Provisional
Pssm-ID: 181547 [Multi-domain] Cd Length: 476 Bit Score: 524.48 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502860087 3 GNKPFNKQTEPRERD-FQVAGLKVPPHSIEAEQSVLGGLMLDNERWDDVAERVVSDDFYTRPHRHIFTEMARLQESGSPI 81
Cdd:PRK08760 9 SNRNRDRDDDDYDRPePRLDQLRVPPHSVEAEQAVLGGLMLAPDALDRVNDQLTENDFYRRDHRLIYRAIRELSEKDRPF 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502860087 82 DLITLAESLERQGQLDSVGGFAYLAELSKNTPSAANISAYADIVRERAVVREMISVANEIAEAGFDPQGRTSEDLLDLAE 161
Cdd:PRK08760 89 DAVTLGEWFESQGKLEQVGDGAYLIELASTTPSAANIAAYAEIVRDKAVLRQLIEVGTTIVNDGFQPEGRESIELLASAE 168
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502860087 162 SRVFKIAESRAnkdEGPKNIADVLDATVARIEQLFQQPHDG--VTGVNTGYDDLNKKTAGLQPSDLIIVAARPSMGKTTF 239
Cdd:PRK08760 169 KAVFKIAEAGA---RGRTDFVAMPGALKDAFEELRNRFENGgnITGLPTGYNDFDAMTAGLQPTDLIILAARPAMGKTTF 245
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502860087 240 AMNLVENAAMLQDKPVLIFSLEMPSEQIMMRSLASLSRVDQTRIRTGQLDDEDWARISGTMGILLEKRnIYIDDSSGLTP 319
Cdd:PRK08760 246 ALNIAEYAAIKSKKGVAVFSMEMSASQLAMRLISSNGRINAQRLRTGALEDEDWARVTGAIKMLKETK-IFIDDTPGVSP 324
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502860087 320 TEVRSRARRIAREHgGIGLIMIDYLQLMRVPSLSDNRTLEIAEISRSLKALAKELHVPVVALSQLNRSLEQRADKRPVNS 399
Cdd:PRK08760 325 EVLRSKCRRLKREH-DLGLIVIDYLQLMSVPGNSENRATEISEISRSLKGLAKELNVPVIALSQLNRSLETRTDKRPVMA 403
|
410 420 430 440 450 460
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 502860087 400 DLRESGSIEQDADLIMFIYRDEVYH-ENSDLKGIAEIIIGKQRNGPIGTVRLTFNGQWSRFDNYA 463
Cdd:PRK08760 404 DLRESGAIEQDADMIVFIYRDDYYNkENSPDKGLAEIIIGKHRGGPTGSCKLKFFGEYTRFDNLA 468
|
|
| DnaB_C |
pfam03796 |
DnaB-like helicase C terminal domain; The hexameric helicase DnaB unwinds the DNA duplex at ... |
205-461 |
1.90e-164 |
|
DnaB-like helicase C terminal domain; The hexameric helicase DnaB unwinds the DNA duplex at the Escherichia coli chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a change in the quaternary structure of the protein involving dimerization of the N-terminal domain has been observed and may occur during the enzymatic cycle. This C-terminal domain contains an ATP-binding site and is therefore probably the site of ATP hydrolysis.
Pssm-ID: 427509 [Multi-domain] Cd Length: 254 Bit Score: 463.81 E-value: 1.90e-164
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502860087 205 GVNTGYDDLNKKTAGLQPSDLIIVAARPSMGKTTFAMNLVENAAMLQDKPVLIFSLEMPSEQIMMRSLASLSRVDQTRIR 284
Cdd:pfam03796 1 GLPTGFTDLDRLTGGLQPGDLIIIAARPSMGKTAFALNIARNAAVKHKKPVAIFSLEMSAEQLVMRLLASEAGVDSQKLR 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502860087 285 TGQLDDEDWARISGTMGILlEKRNIYIDDSSGLTPTEVRSRARRIAREHGgIGLIMIDYLQLMRVPSLSDNRTLEIAEIS 364
Cdd:pfam03796 81 TGQLTDEDWEKLAKAAGRL-SEAPLYIDDTPGLSIAEIRAKARRLKREHG-LGLIVIDYLQLMSGGSRGENRQQEISEIS 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502860087 365 RSLKALAKELHVPVVALSQLNRSLEQRADKRPVNSDLRESGSIEQDADLIMFIYRDEVYHEnSDLKGIAEIIIGKQRNGP 444
Cdd:pfam03796 159 RSLKALAKELNVPVIALSQLSRAVEQRTDKRPQLSDLRESGAIEQDADVVMFLYRDEYYNP-KEPEGKAEIIIAKQRNGP 237
|
250
....*....|....*..
gi 502860087 445 IGTVRLTFNGQWSRFDN 461
Cdd:pfam03796 238 TGTVKLAFLGEYTRFEN 254
|
|
| PRK05595 |
PRK05595 |
replicative DNA helicase; Provisional |
21-462 |
1.93e-162 |
|
replicative DNA helicase; Provisional
Pssm-ID: 235525 [Multi-domain] Cd Length: 444 Bit Score: 466.23 E-value: 1.93e-162
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502860087 21 AGLKVPPHSIEAEQSVLGGLMLDNERWDDVAERVVSDDFYTRPHRHIFTEMARLQESGSPIDLITLAESLERQGQLDSVG 100
Cdd:PRK05595 3 APIRSLPQSIEAEQSVLGAMIIDKTSIAEAAEVLKSEDFYRDSHKVIFSAIIELYQKDIAVDMLTLTENLKSTDKLEAAG 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502860087 101 GFAYLAELSKNTPSAANISAYADIVRERAVVREMISVANEIAEAGFDPQGRTsEDLLDLAESRVFKIAESRANKDEGPkn 180
Cdd:PRK05595 83 GVTYITELSNSIVSTANIQSYIKIVKDKSTLRRLIKSSTEIIENSYNNQDDV-EKVIDSAEKKIFDISEKRTTSDFEP-- 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502860087 181 IADVLDATVARIEQLFQQpHDGVTGVNTGYDDLNKKTAGLQPSDLIIVAARPSMGKTTFAMNLVENAAMLQDKPVLIFSL 260
Cdd:PRK05595 160 LSNVLERGFEQIENLFNN-KGETTGVASGFRELDAKTSGFQKGDMILIAARPSMGKTTFALNIAEYAALREGKSVAIFSL 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502860087 261 EMPSEQIMMRSLASLSRVDQTRIRTGQLDDEDWARISGTMGILlEKRNIYIDDSSGLTPTEVRSRARRIAREHGgIGLIM 340
Cdd:PRK05595 239 EMSKEQLAYKLLCSEANVDMLRLRTGNLEDKDWENIARASGPL-AAAKIFIDDTAGVSVMEMRSKCRRLKIEHG-IDMIL 316
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502860087 341 IDYLQLMRVPSLSDNRTLEIAEISRSLKALAKELHVPVVALSQLNRSLEQRADKRPVNSDLRESGSIEQDADLIMFIYRD 420
Cdd:PRK05595 317 IDYLQLMSGGKGSESRQQEVSEISRSIKALAKEMECPVIALSQLSRAPEQRADHRPMLSDLRESGSIEQDADVVMFLYRD 396
|
410 420 430 440
....*....|....*....|....*....|....*....|..
gi 502860087 421 EVYHENSDLKGIAEIIIGKQRNGPIGTVRLTFNGQWSRFDNY 462
Cdd:PRK05595 397 EYYNKETEDKNVAECIIAKQRNGPTGTVKLAWLGQYSKFGNL 438
|
|
| phage_DnaB |
TIGR03600 |
phage replicative helicase, DnaB family, HK022 subfamily; Members of this family are phage (or ... |
29-452 |
2.24e-162 |
|
phage replicative helicase, DnaB family, HK022 subfamily; Members of this family are phage (or prophage-region) homologs of the bacterial homohexameric replicative helicase DnaB. Some phage may rely on host DnaB, while others encode their own verions. This model describes the largest phage-specific clade among the close homologs of DnaB, but there are, or course, other DnaB homologs from phage that fall outside the scope of this model. [Mobile and extrachromosomal element functions, Prophage functions]
Pssm-ID: 274672 [Multi-domain] Cd Length: 420 Bit Score: 465.34 E-value: 2.24e-162
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502860087 29 SIEAEQSVLGGLMLDNERWDDVAERVVSDDFYTRPHRHIFTEMARLQESGSPIDLITLAESLERQGQLDSVGGFAYLAEL 108
Cdd:TIGR03600 1 SIEAEQAVLGGLLLDNDFIERVMAILKPEHFYSQDHRIIFEAMLDMFAENRPVDPLTLADKLEAEGEAEKVGGLAYLAEI 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502860087 109 SKNTPSAANISAYADIVRERAVVREMISVANEIAEAGFDPQGRTSEDLLDLAESRVFKIAESRANKDeGPKNIADVLDAT 188
Cdd:TIGR03600 81 SNNTPSAANISSYARIVREKAKERKLIAACQRIITLACSPDGGTAEQKVEEAQAALLALTMSDGQED-GFVTFGEVLEDV 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502860087 189 VARIEQLFQqPHDGVTGVNTGYDDLNKKTAGLQPSDLIIVAARPSMGKTTFAMNLVENAAMLQDKPVLIFSLEMPSEQIM 268
Cdd:TIGR03600 160 VRDLDKRFN-PKGELTGLSTGLPKLDRLTNGLVKGDLIVIGARPSMGKTTLALNIAENVALREGKPVLFFSLEMSAEQLG 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502860087 269 MRSLASLSRVDQTRIRTGQLDDEDWARISGTMGILLEKrNIYIDDSSGLTPTEVRSRARRIAREHGGIGLIMIDYLQLMR 348
Cdd:TIGR03600 239 ERLLASKSGINTGNIRTGRFNDSEFNRLLNAVDRLSEK-DLYIDDTGGLTVAQIRSIARRIKRKKGGLDLIVVDYIQLMA 317
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502860087 349 vPSLSDNRTLEIAEISRSLKALAKELHVPVVALSQLNRSLEQRADKRPVNSDLRESGSIEQDADLIMFIYRDEVYHENSD 428
Cdd:TIGR03600 318 -PARGRDRNEELGGISRGLKALAKELDVPVVLLAQLNRGSEKRTDKRPIMSDLRDSGAIEQDADVIGLIHREGYYDAREP 396
|
410 420
....*....|....*....|....
gi 502860087 429 LKGIAEIIIGKQRNGPIGTVRLTF 452
Cdd:TIGR03600 397 PAGIAELILAKNRHGPTGTVELLF 420
|
|
| DnaB_C |
cd00984 |
C-terminal domain of DnaB helicase; DnaB helicase C-terminal domain. The hexameric helicase ... |
205-461 |
1.01e-157 |
|
C-terminal domain of DnaB helicase; DnaB helicase C-terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a change in the quaternary structure of the protein involving dimerization of the N-terminal domain has been observed and may occur during the enzymatic cycle. This C-terminal domain contains an ATP-binding site and is therefore probably the site of ATP hydrolysis.
Pssm-ID: 410864 [Multi-domain] Cd Length: 256 Bit Score: 446.96 E-value: 1.01e-157
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502860087 205 GVNTGYDDLNKKTAGLQPSDLIIVAARPSMGKTTFAMNLVENAAMLQDKPVLIFSLEMPSEQIMMRSLASLSRVDQTRIR 284
Cdd:cd00984 1 GLPTGFTDLDKLTGGLQPGDLIIIAARPSMGKTAFALNIAENIALDEGLPVLFFSLEMSAEQLAERLLSSESGVSLSKLR 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502860087 285 TGQLDDEDWARISGTMGILLEKrNIYIDDSSGLTPTEVRSRARRIAREHGGIGLIMIDYLQLMRVPSLSDNRTLEIAEIS 364
Cdd:cd00984 81 TGRLDDEDWERLTAAMGELSEL-PLYIDDTPGLTVDEIRAKARRLKREHGGLGLIVIDYLQLIRGSKRAENRQQEVAEIS 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502860087 365 RSLKALAKELHVPVVALSQLNRSLEQRADKRPVNSDLRESGSIEQDADLIMFIYRDEVYHENSDLKGIAEIIIGKQRNGP 444
Cdd:cd00984 160 RSLKALAKELNVPVIALSQLNRGVESRTDKRPMLSDLRESGSIEQDADVVIFLYRDEYYDKDSEDKGIAEIIIAKNRNGP 239
|
250
....*....|....*..
gi 502860087 445 IGTVRLTFNGQWSRFDN 461
Cdd:cd00984 240 TGTVYLAFNPEYTRFTD 256
|
|
| PRK09165 |
PRK09165 |
replicative DNA helicase; Provisional |
24-470 |
2.34e-155 |
|
replicative DNA helicase; Provisional
Pssm-ID: 181676 [Multi-domain] Cd Length: 497 Bit Score: 450.10 E-value: 2.34e-155
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502860087 24 KVPPHSIEAEQSVLGGLMLDNERWDDVAERVVSDDFYTRPHRHIFTEMARLQESGSPIDLITLAESLERQGQLDSVGGFA 103
Cdd:PRK09165 19 RELPHNIEAEQALLGAILINNRALDRVSDFLKPEHFFEPLHQRIYEAIAKIIRKGKLATPVTLKTFLENDEALGELGGVQ 98
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502860087 104 YLAELSKNTPSAANISAYADIVRERAVVREMISVANEIAEAGFD-PQGRTSEDLLDLAESRVFKIAESRANkDEGPKNIA 182
Cdd:PRK09165 99 YLAKLATEAVTIINARDYGRIIYDLALRRELINIGEDVVNNAYDaPVDVAPQEQIEDAEQKLYELAETGRY-EGGFQSFG 177
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502860087 183 DVLDATVARIEQLFQQPhDGVTGVNTGYDDLNKKTAGLQPSDLIIVAARPSMGKTTFAMNLVENAA------MLQD---- 252
Cdd:PRK09165 178 TAITEAVDMANAAFKRD-GHLSGISTGLRDLDSKLGGLHPSDLIILAGRPSMGKTALATNIAFNAAkayrreAQPDgskk 256
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502860087 253 ----KPVLIFSLEMPSEQIMMRSLASLSRVDQTRIRTGQLDDEDWARISGTMgILLEKRNIYIDDSSGLTPTEVRSRARR 328
Cdd:PRK09165 257 avngGVVGFFSLEMSAEQLATRILSEQSEISSSKIRRGKISEEDFEKLVDAS-QELQKLPLYIDDTPALSISQLRARARR 335
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502860087 329 IAREHGgIGLIMIDYLQLMRVPSL--SDNRTLEIAEISRSLKALAKELHVPVVALSQLNRSLEQRADKRPVNSDLRESGS 406
Cdd:PRK09165 336 LKRQHG-LDLLVVDYLQLIRGSSKrsSDNRVQEISEITQGLKALAKELNIPVIALSQLSRQVEQRDDKRPQLSDLRESGS 414
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502860087 407 IEQDADLIMFIYRDEVYHENSD-----------------LKGIAEIIIGKQRNGPIGTVRLTFNGQWSRFDNYAGPQYDD 469
Cdd:PRK09165 415 IEQDADVVMFVYREEYYLKRKEpregtpkheewqekmekVHNKAEVIIAKQRHGPTGTVKLAFESEFTRFGDLADRSQLP 494
|
.
gi 502860087 470 E 470
Cdd:PRK09165 495 E 495
|
|
| PRK07773 |
PRK07773 |
replicative DNA helicase; Validated |
24-410 |
8.04e-140 |
|
replicative DNA helicase; Validated
Pssm-ID: 236093 [Multi-domain] Cd Length: 886 Bit Score: 423.01 E-value: 8.04e-140
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502860087 24 KVPPHSIEAEQSVLGGLMLDNERWDDVAERVVSDDFYTRPHRHIFTEMARLQESGSPIDLITLAESLERQGQLDSVGGFA 103
Cdd:PRK07773 22 RQPPQDLAAEQSVLGGMLLSKEAIARVLERLRPGAFYRPAHQNIYDAILDLYGRGEPADLVTVAAELDRRGLLERIGGAP 101
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502860087 104 YLAELSKNTPSAANISAYADIVRERAVVREMISVANEIAEAGFDPqGRTSEDLLDLAESRVFKIAESRANKDEGPknIAD 183
Cdd:PRK07773 102 YLHTLISTVPTAANADYYARIVAEKALLRRLIEAGTRIVQYGYAE-GADVAEVVDRAQAEIYDVTDRRLSEDFVA--LED 178
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502860087 184 VLDATVARIEQLFQQPhDGVTGVNTGYDDLNKKTAGLQPSDLIIVAARPSMGKTTFAMNLVENAAMLQDKPVLIFSLEMP 263
Cdd:PRK07773 179 LLQPTFDEIDAIASSG-GLARGVPTGFTELDAMTNGLHPGQLIIVAARPSMGKTTFGLDFARNCAIRHRLAVAIFSLEMS 257
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502860087 264 SEQIMMRSLASLSRVDQTRIRTGQLDDEDWARISGTMGILLEKrNIYIDDSSGLTPTEVRSRARRIAREHgGIGLIMIDY 343
Cdd:PRK07773 258 KEQLVMRLLSAEAKIKLSDMRSGRMSDDDWTRLARAMGEISEA-PIFIDDTPNLTVMEIRAKARRLRQEA-NLGLIVVDY 335
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 502860087 344 LQLMRVPSLSDNRTLEIAEISRSLKALAKELHVPVVALSQLNRSLEQRADKRPVNSDLRESGSIEQD 410
Cdd:PRK07773 336 LQLMTSGKKYENRQQEVSEISRHLKLLAKELEVPVVALSQLSRGVEQRTDKRPMLSDLRESGCLTGD 402
|
|
| PRK08506 |
PRK08506 |
replicative DNA helicase; Provisional |
28-459 |
2.01e-139 |
|
replicative DNA helicase; Provisional
Pssm-ID: 236278 [Multi-domain] Cd Length: 472 Bit Score: 408.63 E-value: 2.01e-139
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502860087 28 HSIEAEQSVLGGLMLDNERWDDVAERVVSDDFYTRPHRHIFTEMARLQESGSPIDLITLAESLERQGQLDSVggfAYLAE 107
Cdd:PRK08506 5 YDLDIERAVLSSILFSPDKFEEIASVLEPKDFYLPAHQDIFEAMLKLHNEDEPIDEEFIRKKLPKDKKIDEE---ILLEI 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502860087 108 LSknTPSAANISAYADIVRERAVVREMISVANEIAEAGFDpQGRTSEDLLDLAESRVFKIAESRANKDEgpKNIADVLDA 187
Cdd:PRK08506 82 LA--TNPIDNIEAYVEEIKEKSIKRELLSLANTIPEQAVE-EDQKSSDILDEVERELYSITNGSNSEDF--KDSKEVIES 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502860087 188 TVARIEQLFQQPHDGVTGVNTGYDDLNKKTAGLQPSDLIIVAARPSMGKTTFAMNLVENAAMlQDKPVLIFSLEMPSEQI 267
Cdd:PRK08506 157 TMEHIKKQKRLGNKDIIGLDTGFVELNKMTKGFNKGDLIIIAARPSMGKTTLCLNMALKALN-QDKGVAFFSLEMPAEQL 235
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502860087 268 MMRSLASLSRVDQTRIRTGQLDDEDWARISGTMGiLLEKRNIYIDDSSGLTPTEVRSRARRIAREHGGIGLIMIDYLQLM 347
Cdd:PRK08506 236 MLRMLSAKTSIPLQNLRTGDLDDDEWERLSDACD-ELSKKKLFVYDSGYVNIHQVRAQLRKLKSQHPEIGLAVIDYLQLM 314
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502860087 348 RVPSLSDNRTLEIAEISRSLKALAKELHVPVVALSQLNRSLEQRADKRPVNSDLRESGSIEQDADLIMFIYRDEVYHENS 427
Cdd:PRK08506 315 SGSGNFKDRHLQISEISRGLKLLARELDIPIIALSQLNRSLESRADKRPMLSDLRESGAIEQDADIILFVYRDDVYKERE 394
|
410 420 430 440 450
....*....|....*....|....*....|....*....|....*....|....
gi 502860087 428 D--------LKGI--------------AEIIIGKQRNGPIGTVRLTFNGQWSRF 459
Cdd:PRK08506 395 EkekekkakKEGKeerrihfqnksieeAEIIIGKNRNGPTGTVKLRFQKEFTRF 448
|
|
| PRK05636 |
PRK05636 |
replicative DNA helicase; Provisional |
7-463 |
2.70e-126 |
|
replicative DNA helicase; Provisional
Pssm-ID: 180177 [Multi-domain] Cd Length: 505 Bit Score: 376.49 E-value: 2.70e-126
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502860087 7 FNKQTEPRE-RDFqvaglKVPPHSIEAEQSVLGGLMLDNERWDDVAERVVSDDFYTRPHRHIFTEMARLQESGSPIDLIT 85
Cdd:PRK05636 55 FKRREESREyRDF-----RQPPYDNEAEQGVLGAMLLSPDTVIDIVEVLTPEDFYRPAHQLIFQAIIDLFSDNKEIDPVI 129
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502860087 86 LAESLERQGQLDSVGGFAYLAELSKNTPSAANISAYADIVRERAVVREMISVANEIAEAGFD-PQGRTSEDLLDLAESRV 164
Cdd:PRK05636 130 VAGRLDRTNDLERVGGAPYLHTLIQSVPTAANARYYAEIVSEKAVLRRLVDAGTRVVQLGYEgDEGAEIDSVIDRAQQEV 209
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502860087 165 FKIAESRANKDEgpKNIADVLDATVARIEQLfqQPHDGV-TGVNTGYDDLNKKTAGLQPSDLIIVAARPSMGKTTFAMNL 243
Cdd:PRK05636 210 FAVSQKNQSEDY--AVLADILDPTMDELEML--SSQGGIaTGIPTGFKDLDDLTNGLRGGQMIIVAARPGVGKSTLALDF 285
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502860087 244 VENAAMLQDKPVLIFSLEMPSEQIMMRSLASLSRVDQTRIRTGQLDDEDWARISGTMGiLLEKRNIYIDDSSGLTPTEVR 323
Cdd:PRK05636 286 MRSASIKHNKASVIFSLEMSKSEIVMRLLSAEAEVRLSDMRGGKMDEDAWEKLVQRLG-KIAQAPIFIDDSANLTMMEIR 364
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502860087 324 SRARRIAREHGgIGLIMIDYLQLMRVPSLSDNRTLEIAEISRSLKALAKELHVPVVALSQLNRSLEQRADKRPVNSDLRE 403
Cdd:PRK05636 365 SKARRLKQKHD-LKLIVVDYLQLMSSGKRVESRQQEVSEFSRQLKLLAKELDVPLIAISQLNRGPESRTDKRPQLADLRE 443
|
410 420 430 440 450 460
....*....|....*....|....*....|....*....|....*....|....*....|
gi 502860087 404 SGSIEQDADLIMFIYRDEVYHENSDLKGIAEIIIGKQRNGPIGTVRLTFNGQWSRFDNYA 463
Cdd:PRK05636 444 SGSLEQDADMVMLLYRPDSQDKDDERAGEADIILAKHRGGPIDTVQVAHQLHYSRFVDMA 503
|
|
| PRK06321 |
PRK06321 |
replicative DNA helicase; Provisional |
23-468 |
3.90e-119 |
|
replicative DNA helicase; Provisional
Pssm-ID: 180528 [Multi-domain] Cd Length: 472 Bit Score: 356.84 E-value: 3.90e-119
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502860087 23 LKVPPHSIEAEQSVLGGLMLDNERWDDVAERVVSDDFYTRPHRHIFTEMARLQESGSPIDLITLAESLERQGQLDSVGGF 102
Cdd:PRK06321 13 LLSPPNSKESEMIVLGCMLTSVNYLNLAANQLQEDDFYFLEHKIIFRVLQDAFKSDKPIDVHLAGEELKRRNQLNVIGGP 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502860087 103 AYLAELSKNTPSAANISAYADIVRERAVVREMISVANEIAEAGFDpQGRTSEDLLDLAESRVFKIAESR--------ANK 174
Cdd:PRK06321 93 SYLITLAEFAGTSAYIEEYAEIIRSKSILRKMIQTAKEIEKKALE-EPKDVATALDEAQNLLFKISQTTnlaqyvlvADK 171
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502860087 175 DEGPKNIADV--LDATVARIEQLFQQPHD----GVTGVNTGYDDLNKKTAGLQPSDLIIVAARPSMGKTTFAMNLVENAA 248
Cdd:PRK06321 172 LKGLTSSKDKpfLLQLQERQEAFQQSAQGdsspMISGIPTHFIDLDKMINGFSPSNLMILAARPAMGKTALALNIAENFC 251
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502860087 249 MLQDKPVLIFSLEMPSEQIMMRSLASLSRVDQTRIRTGQLDDEDWARISGTMGiLLEKRNIYIDDSSGLTPTEVRSRARR 328
Cdd:PRK06321 252 FQNRLPVGIFSLEMTVDQLIHRIICSRSEVESKKISVGDLSGRDFQRIVSVVN-EMQEHTLLIDDQPGLKITDLRARARR 330
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502860087 329 IAREHGgIGLIMIDYLQLMRVPSL---SDNRTLEIAEISRSLKALAKELHVPVVALSQLNRSLEQRADKRPVNSDLRESG 405
Cdd:PRK06321 331 MKESYD-IQFLIIDYLQLLSGSGNlrnSESRQTEISEISRMLKNLARELNIPILCLSQLSRKVEDRANHRPMMSDLRESG 409
|
410 420 430 440 450 460
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 502860087 406 SIEQDADLIMFIYRDEVYHENsDLKGIAEIIIGKQRNGPIGTVRLTFNGQWSRFDNYAGPQYD 468
Cdd:PRK06321 410 SIEQDSDLVMFLLRREYYDPN-DKPGTAELIVAKNRHGSIGSVPLVFEKEFARFRNYAACEFP 471
|
|
| PRK06749 |
PRK06749 |
replicative DNA helicase; Provisional |
29-461 |
8.61e-99 |
|
replicative DNA helicase; Provisional
Pssm-ID: 168658 [Multi-domain] Cd Length: 428 Bit Score: 303.41 E-value: 8.61e-99
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502860087 29 SIEAEQSVLGGLMLDNERWDDVaeRVVSDDFYTRPHRHIFTEMARLQESGSPIDLITLAESLErQGQLDSVGGFAYLAEL 108
Cdd:PRK06749 5 NVEAEKTVLGSLLLDGELIKEC--RLTEQYFSMPVHKSIFQLMRKMEDEGQPIDLVTFTSRVD-PNFLKGIGGMEYFIGL 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502860087 109 SKNTPSAANISAYADIVRERAVVREMISVANEIAEagfdpQGRTSEDLLDLAESrvfkIAESRANKDEGPKNIADVLDAT 188
Cdd:PRK06749 82 MDGVPTTSNFSYYEGLVRGAWKMYQAGVLGHKMGE-----RLIAEKSEKIIGET----ITALCELEEKDCVCEFDLKDAL 152
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502860087 189 VARIEQLFQQPHDgVTGVNTGYDDLNKKTAGLQPSDLIIVAARPSMGKTTFAMNLVENAAMlQDKPVLIFSLEMPSEQIM 268
Cdd:PRK06749 153 VDLYEELHQDAKE-ITGIETGYTSLNKMTCGLQEGDFVVLGARPSMGKTAFALNVGLHAAK-SGAAVGLFSLEMSSKQLL 230
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502860087 269 MRSLASLSRVDQTRIRTGQ--LDDEDWARISGTMGiLLEKRNIYIDDSSGLTPTEVRSRARRIAREHGGIG-LIMIDYLQ 345
Cdd:PRK06749 231 KRMASCVGEVSGGRLKNPKhrFAMEDWEKVSKAFA-EIGELPLEIYDNAGVTVQDIWMQTRKLKRKHGDKKiLIIVDYLQ 309
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502860087 346 LMRV-PSLSDNRTLEIAEISRSLKALAKELHVPVVALSQLNRSLEQRADKRPVNSDLRESGSIEQDADLIMFIYRDEVYH 424
Cdd:PRK06749 310 LITGdPKHKGNRFQEISEISRKLKLLARELNVCVVALSQLSRSVESRQDKRPLLSDLRETGQIEQDADVIMLMYREDYYD 389
|
410 420 430
....*....|....*....|....*....|....*..
gi 502860087 425 ENSDLKGIAEIIIGKQRNGPIGTVRLTFNGQWSRFDN 461
Cdd:PRK06749 390 KETMQKEMTEIHVAKHRNGPVGSFKLRFLKEFGRFVE 426
|
|
| DnaB |
pfam00772 |
DnaB-like helicase N terminal domain; The hexameric helicase DnaB unwinds the DNA duplex at ... |
25-127 |
5.84e-43 |
|
DnaB-like helicase N terminal domain; The hexameric helicase DnaB unwinds the DNA duplex at the Escherichia coli chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a change in the quaternary structure of the protein involving dimerization of the N-terminal domain has been observed and may occur during the enzymatic cycle. This N-terminal domain is required both for interaction with other proteins in the primosome and for DnaB helicase activity.
Pssm-ID: 395624 [Multi-domain] Cd Length: 103 Bit Score: 147.00 E-value: 5.84e-43
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502860087 25 VPPHSIEAEQSVLGGLMLDNERWDDVAERVVSDDFYTRPHRHIFTEMARLQESGSPIDLITLAESLERQGQLDSVGGFAY 104
Cdd:pfam00772 1 VPPHNIEAEQAVLGALLLDPEAIDEVADILKPEDFYDPAHRLIFEAILDLYDKGEPIDPVTVAEELEKKGKLEDVGGIAY 80
|
90 100
....*....|....*....|...
gi 502860087 105 LAELSKNTPSAANISAYADIVRE 127
Cdd:pfam00772 81 LAELAANVPSAANIEYYARIVKE 103
|
|
| PRK07773 |
PRK07773 |
replicative DNA helicase; Validated |
406-463 |
3.22e-19 |
|
replicative DNA helicase; Validated
Pssm-ID: 236093 [Multi-domain] Cd Length: 886 Bit Score: 90.96 E-value: 3.22e-19
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....*...
gi 502860087 406 SIEQDADLIMFIYRDEVYHENSDLKGIAEIIIGKQRNGPIGTVRLTFNGQWSRFDNYA 463
Cdd:PRK07773 827 SIEQDADVVILLYRPDYYDRDDPRGGEAEFIVAKHRNGPTGTVTLAFQLHLSRFANLA 884
|
|
| RecA-like_Gp4D_helicase |
cd19483 |
RecA-like domain of Escherichia coli bacteriophage T7 Gp4D helicase; This family includes the ... |
226-447 |
9.95e-17 |
|
RecA-like domain of Escherichia coli bacteriophage T7 Gp4D helicase; This family includes the RecA-like domain of the Gp4D fragment of the Gene4 helicase-primase (Gp4) from bacteriophage T7. Gp4D (residues 241-566) is the minimal fragment of the Gp4 that forms hexameric rings, it contains the helicase domain and the linker connecting the helicase and primase domains. Helicases are ring-shaped oligomeric enzymes that unwind DNA at the replication fork; they couple NTP hydrolysis to the unwinding of nucleic acid duplexes into their component strands. This family belongs to the RecA-like NTPase superfamily which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.
Pssm-ID: 410891 [Multi-domain] Cd Length: 231 Bit Score: 79.15 E-value: 9.95e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502860087 226 IIVAARPSMGKTTFAMNLVENAAMLQDKPVLIFSLEMPSEQIMMRSLASLSRVDQTRIRTGqlDDEDWARISGTMGILLE 305
Cdd:cd19483 1 VTIGAGSGIGKSTIVRELAYHLITEHGEKVGIISLEESVEETAKGLAGKHLGKPEPLELPR--DDITEEEEDDAFDNELG 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502860087 306 KRNIYIDDSSGLTPTEVRSRARRIAREHGGIGLIMIDYLQ-LMRVPSLSDNRTlEIAEISRSLKALAKELHVPVVALSQL 384
Cdd:cd19483 79 SGRFFLYDHFGSLDWDNLKEKIRYMVKVLGCKVIVLDHLTiLVSGLDSSDERK-ELDEIMTELAALVKELGVTIILVSHL 157
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 502860087 385 NRSlEQRAD----KRPVNSDLRESGSIEQDADLIMFIYRDEvYHENSDLKGIAEIIIGKQRN----GPIGT 447
Cdd:cd19483 158 RRP-GGGKGheegGEVSESDLRGSSAIAQLSDYVIGLERNK-QADDPVERNTTRVRVLKNRFtgetGIAGT 226
|
|
| 41 |
PHA02542 |
41 helicase; Provisional |
213-421 |
2.42e-11 |
|
41 helicase; Provisional
Pssm-ID: 222864 [Multi-domain] Cd Length: 473 Bit Score: 65.47 E-value: 2.42e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502860087 213 LNKKT-AGLQPSDLIIVAARPSMGKTTFAMNLVEnAAMLQDKPVLIFSLEMPSEQIMMRSLASLSRVDQTRIrtgqlDDE 291
Cdd:PHA02542 179 LNKITkGGAERKTLNVLLAGVNVGKSLGLCSLAA-DYLQQGYNVLYISMEMAEEVIAKRIDANLLDVSLDDI-----DDL 252
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502860087 292 DWARISGTMGILLEKRN----IYIDDSSGLTPTEVRSRARRIAREHGGI-GLIMIDYLQLM---RVPSLSDNRTLEIAEI 363
Cdd:PHA02542 253 SKAEYKAKMEKLRSKTQgkliIKQYPTGGAHAGHFRALLNELKLKKNFKpDVIIVDYLGICassRLRVSSENSYTYVKAI 332
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*...
gi 502860087 364 SRSLKALAKELHVPVVALSQLNRSLEQRADkrPVNSDLRESGSIEQDADLIMFIYRDE 421
Cdd:PHA02542 333 AEELRGLAVEHDVVVWTAAQTTRSGWDSSD--VDMSDTAESAGLPATADFMLAVIETE 388
|
|
| PRK05973 |
PRK05973 |
replicative DNA helicase; Provisional |
220-402 |
1.19e-09 |
|
replicative DNA helicase; Provisional
Pssm-ID: 168322 [Multi-domain] Cd Length: 237 Bit Score: 58.51 E-value: 1.19e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502860087 220 LQPSDLIIVAARPSMGKTTFAMNLVEnAAMLQDKPVLIFSLEMPSEQIMmrslaslsrvdqTRIRTGQLDDEDWARisgt 299
Cdd:PRK05973 61 LKPGDLVLLGARPGHGKTLLGLELAV-EAMKSGRTGVFFTLEYTEQDVR------------DRLRALGADRAQFAD---- 123
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502860087 300 mgiLLEkrniyIDDSSGLTPTEVrsrARRIAREHGGiGLIMIDYLQLM----RVPSLSDNrtleiaeiSRSLKALAKELH 375
Cdd:PRK05973 124 ---LFE-----FDTSDAICADYI---IARLASAPRG-TLVVIDYLQLLdqrrEKPDLSVQ--------VRALKSFARERG 183
|
170 180
....*....|....*....|....*..
gi 502860087 376 VPVVALSQLNRSLEQRADKRPVNSDLR 402
Cdd:PRK05973 184 LIIVFISQIDRSFDPSAKPLPDIRDVR 210
|
|
| AAA_25 |
pfam13481 |
AAA domain; This AAA domain is found in a wide variety of presumed DNA repair proteins. |
220-385 |
3.65e-08 |
|
AAA domain; This AAA domain is found in a wide variety of presumed DNA repair proteins.
Pssm-ID: 463892 [Multi-domain] Cd Length: 193 Bit Score: 53.54 E-value: 3.65e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502860087 220 LQPSDLIIVAARPSMGKTTFAMNLVenAAMLQDKP------------VLIFSLEMPSEQIMMRSLASLSRVDqtrirtgq 287
Cdd:pfam13481 30 LPAGGLGLLAGAPGTGKTTLALDLA--AAVATGKPwlggprvpeqgkVLYVSAEGPADELRRRLRAAGADLD-------- 99
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502860087 288 lDDEDWARISGTMGILLekrniYIDDSSGLTPTEVRSRARRIAREHGGIGLIMIDYLQLMRVPSLSDNRtlEIAEISRSL 367
Cdd:pfam13481 100 -LPARLLFLSLVESLPL-----FFLDRGGPLLDADVDALEAALEEVEDPDLVVIDPLARALGGDENSNS--DVGRLVKAL 171
|
170
....*....|....*...
gi 502860087 368 KALAKELHVPVVALSQLN 385
Cdd:pfam13481 172 DRLARRTGATVLLVHHVG 189
|
|
| RAD55 |
COG0467 |
RecA-superfamily ATPase, KaiC/GvpD/RAD55 family [Signal transduction mechanisms]; |
219-422 |
6.66e-06 |
|
RecA-superfamily ATPase, KaiC/GvpD/RAD55 family [Signal transduction mechanisms];
Pssm-ID: 440235 [Multi-domain] Cd Length: 221 Bit Score: 47.22 E-value: 6.66e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502860087 219 GLQPSDLIIVAARPSMGKTTFAMNLVENAAmLQDKPVLIFSLEMPSEQImMRSLASLSrvdqtrirtgqLDDEDwarisg 298
Cdd:COG0467 16 GLPRGSSTLLSGPPGTGKTTLALQFLAEGL-RRGEKGLYVSFEESPEQL-LRRAESLG-----------LDLEE------ 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502860087 299 tmgiLLEKRNIYIDDSS----GLTPTEVRSRARRIAREHgGIGLIMID----YLQLMRVPSlsdnrtlEIAEISRSLKAL 370
Cdd:COG0467 77 ----YIESGLLRIIDLSpeelGLDLEELLARLREAVEEF-GAKRVVIDslsgLLLALPDPE-------RLREFLHRLLRY 144
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|..
gi 502860087 371 AKELHVPVVALSQLnrsleqradkrPVNSDLRESGSIEQDADLIMFIYRDEV 422
Cdd:COG0467 145 LKKRGVTTLLTSET-----------GGLEDEATEGGLSYLADGVILLRYVEL 185
|
|
| RecA-like_superfamily |
cd01120 |
RecA-like_NTPases; RecA-like NTPases. This superfamily includes the NTP binding domain of F1 ... |
226-408 |
1.35e-05 |
|
RecA-like_NTPases; RecA-like NTPases. This superfamily includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.
Pssm-ID: 410865 [Multi-domain] Cd Length: 119 Bit Score: 44.42 E-value: 1.35e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502860087 226 IIVAARPSMGKTTFAMNLVENAAmLQDKPVLIFSLempseqimmrslasLSRVDqtrirtgqlddedwarisgtmgille 305
Cdd:cd01120 1 ILITGPPGSGKTTLLLQFAEQAL-LSDEPVIFISF--------------LDTIL-------------------------- 39
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502860087 306 krniyiddssgltptevrsRARRIAREHGGIGLIMIDYLQLMrVPSLSDNRTLEIAEISRSLKALAKELHVPVVALSQLN 385
Cdd:cd01120 40 -------------------EAIEDLIEEKKLDIIIIDSLSSL-ARASQGDRSSELLEDLAKLLRAARNTGITVIATIHSD 99
|
170 180
....*....|....*....|...
gi 502860087 386 RSLEqraDKRPVNSDLRESGSIE 408
Cdd:cd01120 100 KFDI---DRGGSSNDERLLKSLR 119
|
|
| KaiC-like |
cd01124 |
Circadian Clock Protein KaiC; KaiC is a circadian clock protein, most studied in cyanobacteria. ... |
206-332 |
2.23e-05 |
|
Circadian Clock Protein KaiC; KaiC is a circadian clock protein, most studied in cyanobacteria. KaiC, an autokinase, autophosphatase, and ATPase, is part of the core oscillator, composed of three proteins: KaiA, KaiB, and KaiC. The circadian oscillation is regulated via KaiC phosphorylation.
Pssm-ID: 410869 [Multi-domain] Cd Length: 222 Bit Score: 45.72 E-value: 2.23e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502860087 206 VNTGYDDLNKKTAGLQPSD-LIIVAARPSMGKTTFAMNLVENAAMLqDKPVLIFSLEMPSEQIMMRSLA----------- 273
Cdd:cd01124 1 VKTGIPGLDELLGGGIPKGsVTLLTGGPGTGKTLFGLQFLYAGAKN-GEPGLFFTFEESPERLLRNAKSfgwdfdemede 79
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 502860087 274 -SLSRVDQTRIRTGQLDDEDWARisgTMGILLEKRN---IYIDDSSGLT-PTEVRSRARRIARE 332
Cdd:cd01124 80 gKLIIVDAPPTEAGRFSLDELLS---RILSIIKSFKakrVVIDSLSGLRrAKEDQMRARRIVIA 140
|
|
| Rad51B |
cd19493 |
RAD51B recombinase; RAD51B recombinase, a RAD51 paralog, plays an important role in DNA repair ... |
235-383 |
4.43e-04 |
|
RAD51B recombinase; RAD51B recombinase, a RAD51 paralog, plays an important role in DNA repair by homologous recombination (HR). HR is an important error-free repair mechanism for chromosomal double-strand break (DSB) which otherwise leads to cell cycle arrest and death. RAD51B, together with the other RAD51 paralogs, RAD51C, RAD51D, XRCC3, and XRCC2, helps recruit RAD51 to the break site.
Pssm-ID: 410901 [Multi-domain] Cd Length: 222 Bit Score: 41.54 E-value: 4.43e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502860087 235 GKTTFAMNLVENAAMLQDKP-----VLIFSLEmpSEQIMMRSLASLSRVDQTRIRTGQLDDEDWARISgtmgillekRNI 309
Cdd:cd19493 23 GKTQFALTLASSAAMPARKGgldggVLYIDTE--SKFSAERLAEIAEARFPEAFSGFMEENERAEEML---------KRV 91
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502860087 310 YIddSSGLTPTEVRSRARRIaREH---GGIGLIMIDYLQLM--RVPSLSDNRTLE----IAEISRSLKALAKELHVPVVA 380
Cdd:cd19493 92 AV--VRVTTLAQLLERLPNL-EEHilsSGVRLVVIDSIAALvrREFGGSDGEVTErhnaLAREASSLKRLAEEFRIAVLV 168
|
...
gi 502860087 381 LSQ 383
Cdd:cd19493 169 TNQ 171
|
|
| AAA_33 |
pfam13671 |
AAA domain; This family of domains contain only a P-loop motif, that is characteriztic of the ... |
225-334 |
2.66e-03 |
|
AAA domain; This family of domains contain only a P-loop motif, that is characteriztic of the AAA superfamily. Many of the proteins in this family are just short fragments so there is no Walker B motif.
Pssm-ID: 463952 [Multi-domain] Cd Length: 143 Bit Score: 38.06 E-value: 2.66e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502860087 225 LIIVAARPSMGKTTFAMNLVENAAMlqdkpVLIfslempSEQIMMRSLASLSRVDQTriRTGQLDDEDWARISGTMGILL 304
Cdd:pfam13671 1 LILLVGLPGSGKSTLARRLLEELGA-----VRL------SSDDERKRLFGEGRPSIS--YYTDATDRTYERLHELARIAL 67
|
90 100 110
....*....|....*....|....*....|
gi 502860087 305 EKRNIYIDDSSGLTPTEvRSRARRIAREHG 334
Cdd:pfam13671 68 RAGRPVILDATNLRRDE-RARLLALAREYG 96
|
|
| |
