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Conserved domains on  [gi|502860819|ref|WP_013095795|]
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taurine ABC transporter permease TauC [Enterobacter cloacae]

Protein Classification

taurine ABC transporter permease TauC( domain architecture ID 10793353)

taurine ABC transporter permease TauC is part of a binding-protein-dependent transport system for taurine

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PRK10160 PRK10160
taurine ABC transporter permease TauC;
1-275 4.31e-160

taurine ABC transporter permease TauC;


:

Pssm-ID: 182276  Cd Length: 275  Bit Score: 445.77  E-value: 4.31e-160
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502860819   1 MSIVFSEKTRRARPVLRWPFSRQITLSVGTLLVLLAVWWLVAAQAWISPLFLPPPGQVLAKLITIAGPQGFMDATLWQHL 80
Cdd:PRK10160   1 MSVLINEKLHSRRLKWRWPLSRQLTLSIGTLAVLLAVWWAVAALQLISPLFLPPPQQVLAKLLTIAGPQGFMDATLWQHL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502860819  81 GASLARILVALLAAVIIGIPVGIAMGLSPTVRGILDPLIELYRPVPPLAYLPLMVIWFGIGETSKILLIYLAIFAPVAMS 160
Cdd:PRK10160  81 AASLTRIVLALLAAVVIGIPVGIAMGLSPTVRGILDPLIELYRPVPPLAYLPLMVIWFGIGETSKILLIYLAIFAPVAMS 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502860819 161 ALAGVKSAQQVRIRAAQSLGASRTQVLLFVILPGALPEILTGLRIGLGVGWSTLVAAELIAATRGLGFMVQSAGEFLATD 240
Cdd:PRK10160 161 ALAGVKSAQQVRIRAAQSLGASRAQVLWFVILPGALPEILTGLRIGLGVGWSTLVAAELIAATRGLGFMVQSAGEFLATD 240

                        250       260       270
                 ....*....|....*....|....*....|....*
gi 502860819 241 VVLAGIAVIAVIAFGLELGLRALQRRLTPWHGEIQ 275
Cdd:PRK10160 241 VVLAGIAVIAIIAFLLELGLRALQRRLTPWHGEVQ 275
 
Name Accession Description Interval E-value
PRK10160 PRK10160
taurine ABC transporter permease TauC;
1-275 4.31e-160

taurine ABC transporter permease TauC;


Pssm-ID: 182276  Cd Length: 275  Bit Score: 445.77  E-value: 4.31e-160
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502860819   1 MSIVFSEKTRRARPVLRWPFSRQITLSVGTLLVLLAVWWLVAAQAWISPLFLPPPGQVLAKLITIAGPQGFMDATLWQHL 80
Cdd:PRK10160   1 MSVLINEKLHSRRLKWRWPLSRQLTLSIGTLAVLLAVWWAVAALQLISPLFLPPPQQVLAKLLTIAGPQGFMDATLWQHL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502860819  81 GASLARILVALLAAVIIGIPVGIAMGLSPTVRGILDPLIELYRPVPPLAYLPLMVIWFGIGETSKILLIYLAIFAPVAMS 160
Cdd:PRK10160  81 AASLTRIVLALLAAVVIGIPVGIAMGLSPTVRGILDPLIELYRPVPPLAYLPLMVIWFGIGETSKILLIYLAIFAPVAMS 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502860819 161 ALAGVKSAQQVRIRAAQSLGASRTQVLLFVILPGALPEILTGLRIGLGVGWSTLVAAELIAATRGLGFMVQSAGEFLATD 240
Cdd:PRK10160 161 ALAGVKSAQQVRIRAAQSLGASRAQVLWFVILPGALPEILTGLRIGLGVGWSTLVAAELIAATRGLGFMVQSAGEFLATD 240

                        250       260       270
                 ....*....|....*....|....*....|....*
gi 502860819 241 VVLAGIAVIAVIAFGLELGLRALQRRLTPWHGEIQ 275
Cdd:PRK10160 241 VVLAGIAVIAIIAFLLELGLRALQRRLTPWHGEVQ 275
TauC COG0600
ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion ...
 46-271 1.06e-70

ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism];


Pssm-ID: 440365 [Multi-domain]  Cd Length: 254  Bit Score: 218.09  E-value: 1.06e-70
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502860819  46 WISPLFLPPPGQVLAKLITIAGpqgfmDATLWQHLGASLARILVALLAAVIIGIPVGIAMGLSPTVRGILDPLIELYRPV 125
Cdd:COG0600   34 LVPPFLLPSPSAVLAALVELLA-----SGELWEHLLASLLRVLLGFALAALLGVPLGLLLGLSRLLRRLLDPLLVFLRPI 108

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502860819 126 PPLAYLPLMVIWFGIGETSKILLIYLAIFAPVAMSALAGVKSAQQVRIRAAQSLGASRTQVLLFVILPGALPEILTGLRI 205
Cdd:COG0600  109 PPLALAPLLILWFGIGEASKIFVIFLGAFFPILLNTAAGVRSVDPELLELARSLGASRWQILRKVVLPAALPYIFTGLRI 188

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 502860819 206 GLGVGWSTLVAAELIAATRGLGFMVQSAGEFLATDVVLAGIAVIAVIAFGLELGLRALQRRLTPWH 271
Cdd:COG0600  189 ALGLAWIGLVVAELLGASSGLGYLILDARQLLDTDLVFAAILVIGLLGLLLDLLLRLLERRLLRWR 254
ntrB TIGR01183
nitrate ABC transporter, permease protein; This model describes the nitrate transport permease ...
 70-251 1.02e-24

nitrate ABC transporter, permease protein; This model describes the nitrate transport permease in bacteria. This is gene product of ntrB. The nitrate transport permease is the integral membrane component of the nitrate transport system and belongs to the ATP-binding cassette (ABC) superfamily. At least in photosynthetic bacteria nitrate assimilation is aided by other proteins derived from the operon which among others include products of ntrA, ntrB, ntrC, ntrD, narB. Functionally ntrC and ntrD resemble the ATP binding components of the binding protein-dependent transport systems. Mutational studies have shown that ntrB and ntrC are mandatory for nitrate accumulation. Nitrate reductase is encoded by narB. [Transport and binding proteins, Anions]


Pssm-ID: 130251  Cd Length: 202  Bit Score: 97.95  E-value: 1.02e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502860819   70 GFMDATLWQHLGASLARILVALLAAVIIGIPVGIAMGLSPTVRGILDPLIELYRPVPPLAYLPLMVIWFGIGETSKILLI 149
Cdd:TIGR01183   9 GGTDKGLFWQIIASLTRVAVGFSIAAIIGIAVGILIGLSKFLNAALDPIFQVLRTIPPLAWLPIALAAFQDAQPAAIFVI 88

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502860819  150 YLAIFAPVAMSALAGVKSAQQVRIRAAQSLGASRTQVLLFVILPGALPEILTGLRIGLGVGWSTLVAAELIAATRGLGFM 229
Cdd:TIGR01183  89 FITAIWPIIINTAVGVQQIPQDYNNVARVLKLSKSDYFLKVLLPAAVPYIFTGLRIAIGLSWLAIVAAEMLMGGVGIGFF 168

                         170       180
                  ....*....|....*....|...
gi 502860819  230 VQSA-GEFLATDVVLAGIAVIAV 251
Cdd:TIGR01183 169 IWDAyNSGSVSEIILAIIYVGLV 191
BPD_transp_1 pfam00528
Binding-protein-dependent transport system inner membrane component; The alignments cover the ...
 98-269 1.95e-12

Binding-protein-dependent transport system inner membrane component; The alignments cover the most conserved region of the proteins, which is thought to be located in a cytoplasmic loop between two transmembrane domains. The members of this family have a variable number of transmembrane helices.


Pssm-ID: 334128 [Multi-domain]  Cd Length: 183  Bit Score: 64.24  E-value: 1.95e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502860819   98 GIPVGIAMGLSP--TVRGILDPLIELYRPVPPLAYLPLMVI-----WFGIGETSKILLIYLAIFAPVAMSALAGVKSAQQ 170
Cdd:pfam00528   1 GIPLGIIAALRRgrRLDRLLRPLIDLLQALPSFVLAILLVViailsILGHGILPAIILALLGWAGYARLIRRAALRSLPS 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502860819  171 VRIRAAQSLGASRTQVLLFVILPGALPEILTGLRIGLGVGWSTLVAAELIAATRGLGFMVQSAGEFLATDVVLAGIAVIA 250
Cdd:pfam00528  81 DLVEAARALGASRWQIFRKIILPNALPPILTGLALAFGGALGGAVLLEFLGSWPGLGLLLIEAILGYDYPEIQGPVLAAA 160

                         170
                  ....*....|....*....
gi 502860819  251 VIAFGLELGLRALQRRLTP 269
Cdd:pfam00528 161 LILLLLNLLVDILQRLLDP 179
TM_PBP2 cd06261
Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding ...
 80-253 2.37e-10

Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and are mainly involved in importing solutes from the environment. The solute is captured by the PBP which delivers it to a gated translocation pathway formed by the two TMs. The two ABCs bind and hydrolyze ATP and drive the transport reaction. For these transporters the ABCs and TMs are on independent polypeptide chains. These systems transport a diverse range of substrates. Most are specific for a single substrate or a group of related substrates; however some transporters are more promiscuous, transporting structurally diverse substrates such as the histidine/lysine and arginine transporter in Enterobacteriaceae. In the latter case, this is achieved through binding different PBPs with different specificities to the TMs. For other promiscuous transporters such as the multiple-sugar transporter Msm of Streptococcus mutans, the PBP has a wide substrate specificity. These transporters include the maltose-maltodextrin, phosphate and sulfate transporters, among others.


Pssm-ID: 119394 [Multi-domain]  Cd Length: 190  Bit Score: 58.44  E-value: 2.37e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502860819  80 LGASLARILVALLAAVIIGIPVGIAMGLS-PTVRGILDPLIELYRPVPPLAYLPLMVIWFGIGETSK---------ILLI 149
Cdd:cd06261    1 LLNTLLLALIATLLALVLGLLLGIILARKrGKLDRLLRRIIDLLLSLPSLVLGLLLVLLFGVLLGWGilpglglpaLILA 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502860819 150 YLAIFAPVAMSALAGVKSAQQVRIRAAQSLGASRTQVLLFVILPGALPEILTGLRIGLGVGWSTLVAAELIAATR----G 225
Cdd:cd06261   81 LLLIAPFARLIRRAALESIPKDLVEAARALGASPWQIFRRIILPLALPPILTGLVLAFARALGEFALVSFLGGGEapgpG 160

                        170       180
                 ....*....|....*....|....*...
gi 502860819 226 LGFMVQSAGEFLATDVVLAGIAVIAVIA 253
Cdd:cd06261  161 TGLLLIFAILFPGDLGVAAAVALILLLL 188
 
Name Accession Description Interval E-value
PRK10160 PRK10160
taurine ABC transporter permease TauC;
1-275 4.31e-160

taurine ABC transporter permease TauC;


Pssm-ID: 182276  Cd Length: 275  Bit Score: 445.77  E-value: 4.31e-160
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502860819   1 MSIVFSEKTRRARPVLRWPFSRQITLSVGTLLVLLAVWWLVAAQAWISPLFLPPPGQVLAKLITIAGPQGFMDATLWQHL 80
Cdd:PRK10160   1 MSVLINEKLHSRRLKWRWPLSRQLTLSIGTLAVLLAVWWAVAALQLISPLFLPPPQQVLAKLLTIAGPQGFMDATLWQHL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502860819  81 GASLARILVALLAAVIIGIPVGIAMGLSPTVRGILDPLIELYRPVPPLAYLPLMVIWFGIGETSKILLIYLAIFAPVAMS 160
Cdd:PRK10160  81 AASLTRIVLALLAAVVIGIPVGIAMGLSPTVRGILDPLIELYRPVPPLAYLPLMVIWFGIGETSKILLIYLAIFAPVAMS 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502860819 161 ALAGVKSAQQVRIRAAQSLGASRTQVLLFVILPGALPEILTGLRIGLGVGWSTLVAAELIAATRGLGFMVQSAGEFLATD 240
Cdd:PRK10160 161 ALAGVKSAQQVRIRAAQSLGASRAQVLWFVILPGALPEILTGLRIGLGVGWSTLVAAELIAATRGLGFMVQSAGEFLATD 240

                        250       260       270
                 ....*....|....*....|....*....|....*
gi 502860819 241 VVLAGIAVIAVIAFGLELGLRALQRRLTPWHGEIQ 275
Cdd:PRK10160 241 VVLAGIAVIAIIAFLLELGLRALQRRLTPWHGEVQ 275
TauC COG0600
ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion ...
 46-271 1.06e-70

ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism];


Pssm-ID: 440365 [Multi-domain]  Cd Length: 254  Bit Score: 218.09  E-value: 1.06e-70
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502860819  46 WISPLFLPPPGQVLAKLITIAGpqgfmDATLWQHLGASLARILVALLAAVIIGIPVGIAMGLSPTVRGILDPLIELYRPV 125
Cdd:COG0600   34 LVPPFLLPSPSAVLAALVELLA-----SGELWEHLLASLLRVLLGFALAALLGVPLGLLLGLSRLLRRLLDPLLVFLRPI 108

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502860819 126 PPLAYLPLMVIWFGIGETSKILLIYLAIFAPVAMSALAGVKSAQQVRIRAAQSLGASRTQVLLFVILPGALPEILTGLRI 205
Cdd:COG0600  109 PPLALAPLLILWFGIGEASKIFVIFLGAFFPILLNTAAGVRSVDPELLELARSLGASRWQILRKVVLPAALPYIFTGLRI 188

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 502860819 206 GLGVGWSTLVAAELIAATRGLGFMVQSAGEFLATDVVLAGIAVIAVIAFGLELGLRALQRRLTPWH 271
Cdd:COG0600  189 ALGLAWIGLVVAELLGASSGLGYLILDARQLLDTDLVFAAILVIGLLGLLLDLLLRLLERRLLRWR 254
ssuC PRK11365
aliphatic sulfonate ABC transporter permease SsuC;
46-271 2.26e-38

aliphatic sulfonate ABC transporter permease SsuC;


Pssm-ID: 183100  Cd Length: 263  Bit Score: 135.45  E-value: 2.26e-38
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502860819  46 WISPLFLPPPGQVLAKLITIAGpqgfmDATLWQHLGASLARILVALLAAVIIGIPVGIAMGLSPTVRGILDPLIELYRPV 125
Cdd:PRK11365  33 WLSTRILPSPEGVVTAFWTLSA-----SGELWQHLAISSWRALIGFSIGGSLGLILGLISGLSRWGERLLDTSIQMLRNV 107

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502860819 126 PPLAYLPLMVIWFGIGETSKILLIYLAIFAPVAMSALAGVKSAQQVRIRAAQSLGASRTQVLLFVILPGALPEILTGLRI 205
Cdd:PRK11365 108 PHLALIPLVILWFGIDESAKIFLVALGTLFPIYINTWHGIRNIDRGLVEMARSYGLSGIPLFIHVILPGALPSIMVGVRF 187

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 502860819 206 GLGVGWSTLVAAELIAATRGLGFMVQSAGEFLATDVVLAGIAVIAVIAFGLELGLRALQRRLTPWH 271
Cdd:PRK11365 188 ALGLMWLTLIVAETISANSGIGYLAMNAREFLQTDVVVVAIILYALLGKLADVSAQLLERLWLRWN 253
ntrB TIGR01183
nitrate ABC transporter, permease protein; This model describes the nitrate transport permease ...
 70-251 1.02e-24

nitrate ABC transporter, permease protein; This model describes the nitrate transport permease in bacteria. This is gene product of ntrB. The nitrate transport permease is the integral membrane component of the nitrate transport system and belongs to the ATP-binding cassette (ABC) superfamily. At least in photosynthetic bacteria nitrate assimilation is aided by other proteins derived from the operon which among others include products of ntrA, ntrB, ntrC, ntrD, narB. Functionally ntrC and ntrD resemble the ATP binding components of the binding protein-dependent transport systems. Mutational studies have shown that ntrB and ntrC are mandatory for nitrate accumulation. Nitrate reductase is encoded by narB. [Transport and binding proteins, Anions]


Pssm-ID: 130251  Cd Length: 202  Bit Score: 97.95  E-value: 1.02e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502860819   70 GFMDATLWQHLGASLARILVALLAAVIIGIPVGIAMGLSPTVRGILDPLIELYRPVPPLAYLPLMVIWFGIGETSKILLI 149
Cdd:TIGR01183   9 GGTDKGLFWQIIASLTRVAVGFSIAAIIGIAVGILIGLSKFLNAALDPIFQVLRTIPPLAWLPIALAAFQDAQPAAIFVI 88

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502860819  150 YLAIFAPVAMSALAGVKSAQQVRIRAAQSLGASRTQVLLFVILPGALPEILTGLRIGLGVGWSTLVAAELIAATRGLGFM 229
Cdd:TIGR01183  89 FITAIWPIIINTAVGVQQIPQDYNNVARVLKLSKSDYFLKVLLPAAVPYIFTGLRIAIGLSWLAIVAAEMLMGGVGIGFF 168

                         170       180
                  ....*....|....*....|...
gi 502860819  230 VQSA-GEFLATDVVLAGIAVIAV 251
Cdd:TIGR01183 169 IWDAyNSGSVSEIILAIIYVGLV 191
OpuBB COG1174
ABC-type proline/glycine betaine transport system, permease component [Amino acid transport ...
 76-270 2.63e-22

ABC-type proline/glycine betaine transport system, permease component [Amino acid transport and metabolism];


Pssm-ID: 440787 [Multi-domain]  Cd Length: 212  Bit Score: 91.65  E-value: 2.63e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502860819  76 LWQHLGASLarilVALLAAVIIGIPVGIAMGLSPTVRGILDPLIELYRPVPPLAYLPLMVIWFGIGETSKILLIYLAIFA 155
Cdd:COG1174   20 LLEHLLLVL----LALLIALLIAVPLGILITRRRRLAGLVLGVANILQTIPSLALLALLIPLLGIGPAPAIIALVLYALL 95

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502860819 156 PVAMSALAGVKSAQQVRIRAAQSLGASRTQVLLFVILPGALPEILTGLRIGL--GVGWSTLVAaeLIAAtRGLGFMVQSA 233
Cdd:COG1174   96 PILRNTYTGLRSVDPAVVEAARGMGMTPWQRLWRVELPLALPVILAGIRTAAvqNIGTATLAA--LIGA-GGLGDLIFDG 172

                        170       180       190
                 ....*....|....*....|....*....|....*..
gi 502860819 234 GEFLATDVVLAGIAVIAVIAFGLELGLRALQRRLTPW 270
Cdd:COG1174  173 LQLNNTALILAGAILVALLALLVDLLLALLERLLTPR 209
PRK10952 PRK10952
proline/glycine betaine ABC transporter permease ProW;
77-230 1.49e-14

proline/glycine betaine ABC transporter permease ProW;


Pssm-ID: 236805  Cd Length: 355  Bit Score: 72.43  E-value: 1.49e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502860819  77 WQHLGASLARILVALLAAVIIGIPVGIAMGLSPTVRGILDPLIELYRPVPPLAYLPLMVIWFGIGETSKILLIYLAIFAP 156
Cdd:PRK10952 143 WSQAMVTLALVLTALLFCIVIGLPLGIWLARSPRAAKIIRPLLDAMQTTPAFVYLVPIVMLFGIGNVPGVVVTIIFALPP 222

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 502860819 157 VAMSALAGVKSAQQVRIRAAQSLGASRTQVLLFVILPGALPEILTGLRIGLGVGWSTLVAAELIAATrGLGFMV 230
Cdd:PRK10952 223 IVRLTILGINQVPADLIEASRSFGASPRQMLFKVQLPLAMPTIMAGVNQTLMLALSMVVIASMIAVG-GLGQMV 295
BPD_transp_1 pfam00528
Binding-protein-dependent transport system inner membrane component; The alignments cover the ...
 98-269 1.95e-12

Binding-protein-dependent transport system inner membrane component; The alignments cover the most conserved region of the proteins, which is thought to be located in a cytoplasmic loop between two transmembrane domains. The members of this family have a variable number of transmembrane helices.


Pssm-ID: 334128 [Multi-domain]  Cd Length: 183  Bit Score: 64.24  E-value: 1.95e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502860819   98 GIPVGIAMGLSP--TVRGILDPLIELYRPVPPLAYLPLMVI-----WFGIGETSKILLIYLAIFAPVAMSALAGVKSAQQ 170
Cdd:pfam00528   1 GIPLGIIAALRRgrRLDRLLRPLIDLLQALPSFVLAILLVViailsILGHGILPAIILALLGWAGYARLIRRAALRSLPS 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502860819  171 VRIRAAQSLGASRTQVLLFVILPGALPEILTGLRIGLGVGWSTLVAAELIAATRGLGFMVQSAGEFLATDVVLAGIAVIA 250
Cdd:pfam00528  81 DLVEAARALGASRWQIFRKIILPNALPPILTGLALAFGGALGGAVLLEFLGSWPGLGLLLIEAILGYDYPEIQGPVLAAA 160

                         170
                  ....*....|....*....
gi 502860819  251 VIAFGLELGLRALQRRLTP 269
Cdd:pfam00528 161 LILLLLNLLVDILQRLLDP 179
TM_PBP2 cd06261
Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding ...
 80-253 2.37e-10

Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and are mainly involved in importing solutes from the environment. The solute is captured by the PBP which delivers it to a gated translocation pathway formed by the two TMs. The two ABCs bind and hydrolyze ATP and drive the transport reaction. For these transporters the ABCs and TMs are on independent polypeptide chains. These systems transport a diverse range of substrates. Most are specific for a single substrate or a group of related substrates; however some transporters are more promiscuous, transporting structurally diverse substrates such as the histidine/lysine and arginine transporter in Enterobacteriaceae. In the latter case, this is achieved through binding different PBPs with different specificities to the TMs. For other promiscuous transporters such as the multiple-sugar transporter Msm of Streptococcus mutans, the PBP has a wide substrate specificity. These transporters include the maltose-maltodextrin, phosphate and sulfate transporters, among others.


Pssm-ID: 119394 [Multi-domain]  Cd Length: 190  Bit Score: 58.44  E-value: 2.37e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502860819  80 LGASLARILVALLAAVIIGIPVGIAMGLS-PTVRGILDPLIELYRPVPPLAYLPLMVIWFGIGETSK---------ILLI 149
Cdd:cd06261    1 LLNTLLLALIATLLALVLGLLLGIILARKrGKLDRLLRRIIDLLLSLPSLVLGLLLVLLFGVLLGWGilpglglpaLILA 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502860819 150 YLAIFAPVAMSALAGVKSAQQVRIRAAQSLGASRTQVLLFVILPGALPEILTGLRIGLGVGWSTLVAAELIAATR----G 225
Cdd:cd06261   81 LLLIAPFARLIRRAALESIPKDLVEAARALGASPWQIFRRIILPLALPPILTGLVLAFARALGEFALVSFLGGGEapgpG 160

                        170       180
                 ....*....|....*....|....*...
gi 502860819 226 LGFMVQSAGEFLATDVVLAGIAVIAVIA 253
Cdd:cd06261  161 TGLLLIFAILFPGDLGVAAAVALILLLL 188
COG4986 COG4986
ABC-type anion transport system, duplicated permease component [Inorganic ion transport and ...
 81-267 3.98e-07

ABC-type anion transport system, duplicated permease component [Inorganic ion transport and metabolism];


Pssm-ID: 444010 [Multi-domain]  Cd Length: 576  Bit Score: 50.61  E-value: 3.98e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502860819  81 GASLARILVALLAAVIIGIPVGIAMGLSPTVRGILDPLIELYRPVPPLAYLPLMVIWF-GIGETSKILLIYLAIFAP--- 156
Cdd:COG4986  372 LLTLLRVVVLIALASLIWVPVGVWIGLRPRLARRLQPVAQFLASFPANLLFPVAVLLIvRFGLNPNIWLSPLMILGTqwy 451

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502860819 157 VAMSALAGVKSAQQVRIRAAQSLGASRTQVLLFVILPGALPEILTGLRIGLGVGWSTLVAAELIA------ATRGLGFMV 230
Cdd:COG4986  452 ILFNVIAGASAIPNDLREAARNFGLRGWLWWRRLILPGIFPYYVTGAITASGGAWNASIVAEYVSwgdttlQATGLGAYI 531

                        170       180       190
                 ....*....|....*....|....*....|....*..
gi 502860819 231 QSAGEFLATDVVLAGIAVIAVIAFGLElglRALQRRL 267
Cdd:COG4986  532 AQATAAGDFPRILLGIAVMSLFVVLFN---RLVWRPL 565
PhnE TIGR01097
phosphonate ABC transporter, permease protein PhnE; Phosphonates are a class of compound ...
 75-267 3.07e-06

phosphonate ABC transporter, permease protein PhnE; Phosphonates are a class of compound analogous to organic phosphates, but in which the C-O-P linkage is replaced by a direct, stable C-P bond. Some bacteria can utilize phosphonates as a source of phosphorus. This family consists of permease proteins of known or predicted phosphonate ABC transporters. Often this protein is found as a duplicated pair, occasionally as a fused pair. Certain "second" copies score in between the trusted and noise cutoff and should be considered true hits (by context). [Transport and binding proteins, Anions]


Pssm-ID: 273441 [Multi-domain]  Cd Length: 250  Bit Score: 47.15  E-value: 3.07e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502860819   75 TLWQHLGASLARILVALLAAVIIGIPVGI----AMGLSPTVRGILDPLIELYRPVPPLAYLPLMVIWFGIGETSKILLIY 150
Cdd:TIGR01097  55 RILKALLETLAMAILGTVLAAVLAVPLALlaarNITPSPWLYGLARLLLNFLRAIPELVWALIFVAAVGLGPFAGVLALA 134

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502860819  151 LAIFAPVAMSALAGVKSAQQVRIRAAQSLGASRTQVLLFVILPGALPEIL--TGLRIGLGVGWSTLVAaeLIAATrGLGF 228
Cdd:TIGR01097 135 FHTVGFLGKLFAEAIEEVDPGPVEALRATGASKLQVIRYGVLPQVLPQFLsyTLYRFEINVRAAAVLG--LVGAG-GIGL 211

                         170       180       190
                  ....*....|....*....|....*....|....*....
gi 502860819  229 MVQSAGEFLATDVVLAGIAVIAVIAFGLELGLRALQRRL 267
Cdd:TIGR01097 212 ELDTAIGLFDYDEVSAIILVILVVVVIIDLISARLRRRL 250
MetP COG2011
ABC-type methionine transport system, permease component [Amino acid transport and metabolism]; ...
 72-203 8.74e-06

ABC-type methionine transport system, permease component [Amino acid transport and metabolism];


Pssm-ID: 441614  Cd Length: 220  Bit Score: 45.43  E-value: 8.74e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502860819  72 MDATLWQHLGASLARILVALLAAVIIGIPVGIAMGLS--------PTVRGILDPLIELYRPVPplaYLPLMVIWF----- 138
Cdd:COG2011    8 LWPLLLQATGETLYMVGVSTLIAVLLGLPLGVLLVLTrpggllpnPVLYRVLGVIVNIFRSIP---FIILLVALIpltrl 84

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 502860819 139 ----GIGETSKIL-LIYLAI--FAPVAMSALAGVKSAqqvRIRAAQSLGASRTQVLLFVILPGALPEILTGL 203
Cdd:COG2011   85 ivgtSIGTTAAIVpLTIAAIpfFARLVENALREVDPG---VIEAAQAMGASPWQIIFKVLLPEALPSLILGL 153
HisM COG0765
ABC-type amino acid transport system, permease component [Amino acid transport and metabolism]; ...
 76-267 2.35e-04

ABC-type amino acid transport system, permease component [Amino acid transport and metabolism];


Pssm-ID: 440528 [Multi-domain]  Cd Length: 218  Bit Score: 41.21  E-value: 2.35e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502860819  76 LWQHLGASLARILVALLAAVIIGIPVGIAMGL-SPTVRGILDPLIELYRPVPPLayLPLMVIWFGIGEtskiLLIYLAIF 154
Cdd:COG0765   15 LLEGLLVTLLLTVLAIVLGLVLGLLLALARLSpNPVLRWLATAYVEFFRGTPLL--VQLFFIYFGLPL----LGIDLSPF 88

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502860819 155 --APVAMSALAGVKSAQQVR----------IRAAQSLGASRTQVLLFVILPGALPEI---LTGLRIGLgVGWSTLVAAel 219
Cdd:COG0765   89 vaAVIALTLNSAAYLAEIVRagiqsvpkgqWEAARALGLSRWQTMRRIILPQALRIIlppLGNEFISL-LKDTSLVSV-- 165

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*....
gi 502860819 220 IAATRGLGFMVQSAGEFLATDVVLAGIAVI-AVIAFGLELGLRALQRRL 267
Cdd:COG0765  166 IGVPELTRAAQQIASRTFRPFEVYLVAALIyLVLTLPLSLLARRLERRL 214
PotC COG1177
ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport ...
 71-202 9.72e-04

ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism];


Pssm-ID: 440790 [Multi-domain]  Cd Length: 262  Bit Score: 39.71  E-value: 9.72e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502860819  71 FMDATLWQHLGASLARILVALLAAVIIGIPVGIAMG-LSPTVRGILDPLIELYRPVPPLAY-LPLMVIWFGIGETSKILL 148
Cdd:COG1177   54 FSDPRLLDALLNSLLIALLSTLLATVLGTPAALALArYRFRGRRLLLALLLLPLVVPGIVLgVALLLLFSALGLSGGLWG 133

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 502860819 149 IYLAIFAP----VAMSALAGVKSAQQVRIRAAQSLGASRTQVLLFVILPGALPEILTG 202
Cdd:COG1177  134 LILAHVVFtlpfVVLVVLARLQGFDPSLEEAARDLGASPWQTFRRVTLPLIAPGILAG 191
PhnE COG3639
ABC-type phosphate/phosphonate transport system, permease component [Inorganic ion transport ...
 74-268 1.41e-03

ABC-type phosphate/phosphonate transport system, permease component [Inorganic ion transport and metabolism];


Pssm-ID: 442856 [Multi-domain]  Cd Length: 244  Bit Score: 39.29  E-value: 1.41e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502860819  74 ATLWQHLGASLARILVALLAAVIIGIPVGIA----MGLSPTVRGILDPLIELYRPVPPLAYLPLMVIWFGIGETSKILLI 149
Cdd:COG3639   47 PDLLSALLETLAIALLGTLLGAVLALPLAFLaarnLAPNPWVRLLARRLLNVLRAIPELVWALIFVAAVGLGPFAGVLAL 126

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502860819 150 YLAIFAPVA--MS-ALAGVKSAQqvrIRAAQSLGASRTQVLLFVILPGALPEIL--TGLRIGLGVGWSTLVAaeLIAATr 224
Cdd:COG3639  127 AIHTIGFLGklFAeAIEEIDPGP---VEALRATGASRLQVIRYGVLPQVLPQFLsyTLYRFEINIRAATVLG--LVGAG- 200

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....
gi 502860819 225 GLGFMVQSAGEFLATDVVLAGIAVIAVIAFGLELGLRALQRRLT 268
Cdd:COG3639  201 GIGLLLNEAIRLFQYDEVAAILLVILVLVLLIDLLSARLRRRLI 244
FbpB COG1178
ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism];
71-203 1.75e-03

ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism];


Pssm-ID: 440791 [Multi-domain]  Cd Length: 538  Bit Score: 39.37  E-value: 1.75e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502860819  71 FMDATLWQHLGASLARILVALLAAVIIGIPVGIAMGLSPT-VRGILDPLIELYRPVPP----LAYLPLMVIWFGIGETSK 145
Cdd:COG1178  331 LLDPSLLRALLNSLLLALLAALLAVLLALLLAYLVRRRRGrLARLLDRLAMLPYAVPGivlgLGLLLLFNRPLPLLLYGT 410

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 502860819 146 ILLI---YLAIFAPVAM-SALAGVKSAQQVRIRAAQSLGASRTQVLLFVILPGALPEILTGL 203
Cdd:COG1178  411 LAILvlaYVVRFLPFALrSLEAALAQIDPSLEEAARSLGASPLRTLRRVTLPLLRPGLLAAA 472
DppB COG0601
ABC-type dipeptide/oligopeptide/nickel transport system, permease component [Amino acid ...
 76-252 2.49e-03

ABC-type dipeptide/oligopeptide/nickel transport system, permease component [Amino acid transport and metabolism, Inorganic ion transport and metabolism];


Pssm-ID: 440366 [Multi-domain]  Cd Length: 314  Bit Score: 38.51  E-value: 2.49e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502860819  76 LWQHLGASLARILVALLAAVIIGIPVGIAMGLSPtvRGILDPLIELY----RPVPPLAYLPLMVIWFGI--------GET 143
Cdd:COG0601   91 IAERLPVTLELALLALLLALLIGIPLGILAALRR--GSWLDRLITVLallgISIPSFWLGLLLILLFAVklgwlpvsGRV 168

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502860819 144 SK-----------------ILLIYLAIFAPVAMSALAGVKSAQQVriRAAQSLGASRTQVLLFVILPGALPEILT--GLR 204
Cdd:COG0601  169 SPwedfldalrhlilpaltLALGSLAGIARLTRSSMLEVLGQDYV--RTARAKGLSERRVLLRHALRNALIPVVTvlGLQ 246

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*...
gi 502860819 205 IGLGVGWSTLVaaELIAATRGLGFMVQSAGEFLATDVVLAGIAVIAVI 252
Cdd:COG0601  247 LGGLLGGAVVV--ETVFSWPGLGRLLVDAILNRDYPVVQGIVLLIAVL 292
PstA COG0581
ABC-type phosphate transport system, permease component [Inorganic ion transport and ...
 175-208 8.64e-03

ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism];


Pssm-ID: 440346 [Multi-domain]  Cd Length: 259  Bit Score: 36.94  E-value: 8.64e-03
                         10        20        30
                 ....*....|....*....|....*....|....
gi 502860819 175 AAQSLGASRTQVLLFVILPGALPEILTGLRIGLG 208
Cdd:COG0581  147 ASYALGATKWQTIRKVVLPAALPGILTGVILAIA 180
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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