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Conserved domains on  [gi|502862563|ref|WP_013097539|]
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MULTISPECIES: GntR family transcriptional regulator [Enterobacter]

Protein Classification

PRK09764 family protein( domain architecture ID 11484474)

PRK09764 family protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PRK09764 PRK09764
GntR family transcriptional regulator;
1-238 2.74e-163

GntR family transcriptional regulator;


:

Pssm-ID: 182065 [Multi-domain]  Cd Length: 240  Bit Score: 450.82  E-value: 2.74e-163
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502862563   1 MGNKPRYRQIADVFREKINAGELKPGDALPTESSLQEAFSVSRVTVRQALKLLADEQIIESIQGSGSYVKEERVNYDIYQ 80
Cdd:PRK09764   1 MGHKPLYRQIADRIREQIARGELKPGDALPTESALQTEFGVSRVTVRQALRQLVEQQILESIQGSGTYVKEERVNYDIFQ 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502862563  81 LTGFYEKLADRNVDTHSDVKIFEVVKADTRLAATLAIGEDDKVWHVKRVRFIKQKPVNLEETWMPLAMFPDLTWEVMEKS 160
Cdd:PRK09764  81 LTSFDEKLSDRHVDTHSEVLIFEVIPADDFLQQQLQITAQDRVWHVKRVRYRKQKPMALEETWMPLALFPDLTWQVMENS 160

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 502862563 161 KYHYVEQIKKLVIDRSEQELVPVMPSEEAIAALALDPAKPILEKVSRGFLKDGRVFEYSRNVFNTDDYKFTLVAKRRQ 238
Cdd:PRK09764 161 KYHFIEEVKKMVIDRSEQEIIPLMPTEEMSRLLNISQTKPILEKVSRGYLVDGRVFEYSRNAFNTDDYKFTLIAQRKS 238
 
Name Accession Description Interval E-value
PRK09764 PRK09764
GntR family transcriptional regulator;
1-238 2.74e-163

GntR family transcriptional regulator;


Pssm-ID: 182065 [Multi-domain]  Cd Length: 240  Bit Score: 450.82  E-value: 2.74e-163
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502862563   1 MGNKPRYRQIADVFREKINAGELKPGDALPTESSLQEAFSVSRVTVRQALKLLADEQIIESIQGSGSYVKEERVNYDIYQ 80
Cdd:PRK09764   1 MGHKPLYRQIADRIREQIARGELKPGDALPTESALQTEFGVSRVTVRQALRQLVEQQILESIQGSGTYVKEERVNYDIFQ 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502862563  81 LTGFYEKLADRNVDTHSDVKIFEVVKADTRLAATLAIGEDDKVWHVKRVRFIKQKPVNLEETWMPLAMFPDLTWEVMEKS 160
Cdd:PRK09764  81 LTSFDEKLSDRHVDTHSEVLIFEVIPADDFLQQQLQITAQDRVWHVKRVRYRKQKPMALEETWMPLALFPDLTWQVMENS 160

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 502862563 161 KYHYVEQIKKLVIDRSEQELVPVMPSEEAIAALALDPAKPILEKVSRGFLKDGRVFEYSRNVFNTDDYKFTLVAKRRQ 238
Cdd:PRK09764 161 KYHFIEEVKKMVIDRSEQEIIPLMPTEEMSRLLNISQTKPILEKVSRGYLVDGRVFEYSRNAFNTDDYKFTLIAQRKS 238
MngR COG2188
DNA-binding transcriptional regulator, GntR family [Transcription];
1-237 5.91e-79

DNA-binding transcriptional regulator, GntR family [Transcription];


Pssm-ID: 441791 [Multi-domain]  Cd Length: 238  Bit Score: 237.07  E-value: 5.91e-79
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502862563   1 MGNKPRYRQIADVFREKINAGELKPGDALPTESSLQEAFSVSRVTVRQALKLLADEQIIESIQGSGSYVKEERVNYDIYQ 80
Cdd:COG2188    1 SSPVPLYLQIADALRERIESGELPPGDRLPSERELAEEFGVSRMTVRKALDELVEEGLLERRQGRGTFVAEPKIEYPLSR 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502862563  81 LTGFYEKLADRNVDTHSDVKIFEVVKADTRLAATLAIGEDDKVWHVKRVRFIKQKPVNLEETWMPLAMFPDLTWEVMEK- 159
Cdd:COG2188   81 LTSFTEELRARGREPSTRVLSAERVPADEEVAEALGLPPGAPVLRIERLRLADGEPVALETSYLPAALFPGLLEEDLETg 160

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 502862563 160 SKYHYVEQIKKLVIDRSEQELVPVMPSEEAIAALALDPAKPILEKVSRGFLKDGRVFEYSRNVFNTDDYKFTLVAKRR 237
Cdd:COG2188  161 SLYELLEERYGLRITRAEQRIEAVLADAEEAELLGVPPGAPVLVIERVTYDADGRPVEYSRSYYRGDRYRFVVELRRR 238
trehalos_R_Bsub TIGR02404
trehalose operon repressor, B. subtilis-type; This family consists of repressors of the GntR ...
 6-236 1.06e-36

trehalose operon repressor, B. subtilis-type; This family consists of repressors of the GntR family typically associated with trehalose utilization operons. Trehalose is imported as trehalose-6-phosphate and then hydrolyzed by alpha,alpha-phosphotrehalase to glucose and glucose-6-P. This family includes repressors mostly from Gram-positive lineages and does not include the TreR from E. coli. [Regulatory functions, DNA interactions]


Pssm-ID: 274116 [Multi-domain]  Cd Length: 233  Bit Score: 129.02  E-value: 1.06e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502862563    6 RYRQIADVFREKINAGELKPGDALPTESSLQEAFSVSRVTVRQALKLLADEQIIESIQGSGSYV-KEERVNYDIYQLTGF 84
Cdd:TIGR02404   1 KYEQIYQDLEQKITKGQYKEGDYLPSEHELMDQYGASRETVRKALNLLTERGYIQKIQGKGSIVlNRKQIEFPISGITSF 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502862563   85 YEKLADRNVDTHSDVKIFEV-VKADTRLAATLAIGEDDKVWHVKRVRFIKQKPVNLEETWMPLAMFPDLTWEVMEKSKYH 163
Cdd:TIGR02404  81 KELNETLGLDSKTEVVELDKeDPLPETLAQLTGLEEGSLIWRIKRVRVIDGEAVILDIDYLLKELVPGLTKEIAEDSIYQ 160

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 502862563  164 YVEQIKKLVIDRSEQELVPVMPSEEAIAALALDPAKPILEKVSRGFLKDGRVFEYSRNVFNTDDYKFTLVAKR 236
Cdd:TIGR02404 161 YLENELGLAISYAQKEITVEPCTDEDKKLLDLDGDDHVVVVKSKTFLEDTRQFQYTESRHRLDKFKFVDFARR 233
UTRA pfam07702
UTRA domain; The UbiC transcription regulator-associated (UTRA) domain is a conserved ...
 90-229 1.48e-33

UTRA domain; The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain that has a similar fold to pfam04345. It is believed to modulate activity of bacterial transcription factors in response to binding small molecules sugar phosphates and urocanate, Matilla et. al., FEMS Microbiology Reviews, fuab043, 45, 2021, 1. https://doi.org/10.1093/femsre/fuab043).


Pssm-ID: 429607 [Multi-domain]  Cd Length: 141  Bit Score: 118.08  E-value: 1.48e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502862563   90 DRNVDTHSDVKIFEVVKADTRLAATLAIGEDDKVWHVKRVRFIKQKPVNLEETWMPLAMFPDLTWEVMEK-SKYHYVEQI 168
Cdd:pfam07702   1 AQGREPKTEVLSLEEVPASAEIAEALGLPPGEPVYRIERLRYADGEPVALEEDYLPAELVPDLLEEDLEEgSLYDYLEER 80

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 502862563  169 KKLVIDRSEQELVPVMPSEEAIAALALDPAKPILEKVSRGFLKDGRVFEYSRNVFNTDDYK 229
Cdd:pfam07702  81 YGLPITRAEQTIEAVLADAEEAELLGISPGAPVLLIERVTYDQDGRPVEYSRSYYRGDRYR 141
UTRA smart00866
The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; ...
 90-229 8.03e-32

The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; It has a similar fold to HutC/FarR-like bacterial transcription factors of the GntR family. It is believed to modulate activity of bacterial transcription factors in response to binding small molecules.


Pssm-ID: 214869 [Multi-domain]  Cd Length: 143  Bit Score: 113.54  E-value: 8.03e-32
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502862563    90 DRNVDTHSDVKIFEVVKADTRLAATLAIGEDDKVWHVKRVRFIKQKPVNLEETWMPLAMFPDLTWEVMEKSKYHYVEQIK 169
Cdd:smart00866   1 AQGRKPTTKVLSFERVPADEELAEALGLPPGDPVYRIERLRLADGEPVALETTYLPAALFPGLLEEDLSGSLYEYLEERL 80

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 502862563   170 KLVI---DRSEQELVPVMPSEEAIAALALDPAKPILEKVSRGFLKDGRVFEYSRNVFNTDDYK 229
Cdd:smart00866  81 GLKIvrsTRAEQTITAVLADEEEAELLGLPPGAPLLVVERVTYDDDGRPVEYSRSYYRGDRFR 143
WHTH_GntR cd07377
Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional ...
 5-70 3.84e-25

Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; This CD represents the winged HTH DNA-binding domain of the GntR (named after the gluconate operon repressor in Bacillus subtilis) family of bacterial transcriptional regulators and their putative homologs found in eukaryota and archaea. The GntR family has over 6000 members distributed among almost all bacterial species, which is comprised of FadR, HutC, MocR, YtrA, AraR, PlmA, and other subfamilies for the regulation of the most varied biological process. The monomeric proteins of the GntR family are characterized by two function domains: a small highly conserved winged helix-turn-helix prokaryotic DNA binding domain in the N-terminus, and a very diverse regulatory ligand-binding domain in the C-terminus for effector-binding/oligomerization, which provides the basis for the subfamily classifications. Binding of the effector to GntR-like transcriptional regulators is presumed to result in a conformational change that regulates the DNA-binding affinity of the repressor. The GntR-like proteins bind as dimers, where each monomer recognizes a half-site of 2-fold symmetric DNA sequences.


Pssm-ID: 153418 [Multi-domain]  Cd Length: 66  Bit Score: 93.67  E-value: 3.84e-25
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 502862563   5 PRYRQIADVFREKINAGELKPGDALPTESSLQEAFSVSRVTVRQALKLLADEQIIESIQGSGSYVK 70
Cdd:cd07377    1 PLYEQIADQLREAILSGELKPGDRLPSERELAEELGVSRTTVREALRELEAEGLVERRPGRGTFVA 66
 
Name Accession Description Interval E-value
PRK09764 PRK09764
GntR family transcriptional regulator;
1-238 2.74e-163

GntR family transcriptional regulator;


Pssm-ID: 182065 [Multi-domain]  Cd Length: 240  Bit Score: 450.82  E-value: 2.74e-163
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502862563   1 MGNKPRYRQIADVFREKINAGELKPGDALPTESSLQEAFSVSRVTVRQALKLLADEQIIESIQGSGSYVKEERVNYDIYQ 80
Cdd:PRK09764   1 MGHKPLYRQIADRIREQIARGELKPGDALPTESALQTEFGVSRVTVRQALRQLVEQQILESIQGSGTYVKEERVNYDIFQ 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502862563  81 LTGFYEKLADRNVDTHSDVKIFEVVKADTRLAATLAIGEDDKVWHVKRVRFIKQKPVNLEETWMPLAMFPDLTWEVMEKS 160
Cdd:PRK09764  81 LTSFDEKLSDRHVDTHSEVLIFEVIPADDFLQQQLQITAQDRVWHVKRVRYRKQKPMALEETWMPLALFPDLTWQVMENS 160

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 502862563 161 KYHYVEQIKKLVIDRSEQELVPVMPSEEAIAALALDPAKPILEKVSRGFLKDGRVFEYSRNVFNTDDYKFTLVAKRRQ 238
Cdd:PRK09764 161 KYHFIEEVKKMVIDRSEQEIIPLMPTEEMSRLLNISQTKPILEKVSRGYLVDGRVFEYSRNAFNTDDYKFTLIAQRKS 238
MngR COG2188
DNA-binding transcriptional regulator, GntR family [Transcription];
1-237 5.91e-79

DNA-binding transcriptional regulator, GntR family [Transcription];


Pssm-ID: 441791 [Multi-domain]  Cd Length: 238  Bit Score: 237.07  E-value: 5.91e-79
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502862563   1 MGNKPRYRQIADVFREKINAGELKPGDALPTESSLQEAFSVSRVTVRQALKLLADEQIIESIQGSGSYVKEERVNYDIYQ 80
Cdd:COG2188    1 SSPVPLYLQIADALRERIESGELPPGDRLPSERELAEEFGVSRMTVRKALDELVEEGLLERRQGRGTFVAEPKIEYPLSR 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502862563  81 LTGFYEKLADRNVDTHSDVKIFEVVKADTRLAATLAIGEDDKVWHVKRVRFIKQKPVNLEETWMPLAMFPDLTWEVMEK- 159
Cdd:COG2188   81 LTSFTEELRARGREPSTRVLSAERVPADEEVAEALGLPPGAPVLRIERLRLADGEPVALETSYLPAALFPGLLEEDLETg 160

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 502862563 160 SKYHYVEQIKKLVIDRSEQELVPVMPSEEAIAALALDPAKPILEKVSRGFLKDGRVFEYSRNVFNTDDYKFTLVAKRR 237
Cdd:COG2188  161 SLYELLEERYGLRITRAEQRIEAVLADAEEAELLGVPPGAPVLVIERVTYDADGRPVEYSRSYYRGDRYRFVVELRRR 238
trehalos_R_Bsub TIGR02404
trehalose operon repressor, B. subtilis-type; This family consists of repressors of the GntR ...
 6-236 1.06e-36

trehalose operon repressor, B. subtilis-type; This family consists of repressors of the GntR family typically associated with trehalose utilization operons. Trehalose is imported as trehalose-6-phosphate and then hydrolyzed by alpha,alpha-phosphotrehalase to glucose and glucose-6-P. This family includes repressors mostly from Gram-positive lineages and does not include the TreR from E. coli. [Regulatory functions, DNA interactions]


Pssm-ID: 274116 [Multi-domain]  Cd Length: 233  Bit Score: 129.02  E-value: 1.06e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502862563    6 RYRQIADVFREKINAGELKPGDALPTESSLQEAFSVSRVTVRQALKLLADEQIIESIQGSGSYV-KEERVNYDIYQLTGF 84
Cdd:TIGR02404   1 KYEQIYQDLEQKITKGQYKEGDYLPSEHELMDQYGASRETVRKALNLLTERGYIQKIQGKGSIVlNRKQIEFPISGITSF 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502862563   85 YEKLADRNVDTHSDVKIFEV-VKADTRLAATLAIGEDDKVWHVKRVRFIKQKPVNLEETWMPLAMFPDLTWEVMEKSKYH 163
Cdd:TIGR02404  81 KELNETLGLDSKTEVVELDKeDPLPETLAQLTGLEEGSLIWRIKRVRVIDGEAVILDIDYLLKELVPGLTKEIAEDSIYQ 160

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 502862563  164 YVEQIKKLVIDRSEQELVPVMPSEEAIAALALDPAKPILEKVSRGFLKDGRVFEYSRNVFNTDDYKFTLVAKR 236
Cdd:TIGR02404 161 YLENELGLAISYAQKEITVEPCTDEDKKLLDLDGDDHVVVVKSKTFLEDTRQFQYTESRHRLDKFKFVDFARR 233
UTRA pfam07702
UTRA domain; The UbiC transcription regulator-associated (UTRA) domain is a conserved ...
 90-229 1.48e-33

UTRA domain; The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain that has a similar fold to pfam04345. It is believed to modulate activity of bacterial transcription factors in response to binding small molecules sugar phosphates and urocanate, Matilla et. al., FEMS Microbiology Reviews, fuab043, 45, 2021, 1. https://doi.org/10.1093/femsre/fuab043).


Pssm-ID: 429607 [Multi-domain]  Cd Length: 141  Bit Score: 118.08  E-value: 1.48e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502862563   90 DRNVDTHSDVKIFEVVKADTRLAATLAIGEDDKVWHVKRVRFIKQKPVNLEETWMPLAMFPDLTWEVMEK-SKYHYVEQI 168
Cdd:pfam07702   1 AQGREPKTEVLSLEEVPASAEIAEALGLPPGEPVYRIERLRYADGEPVALEEDYLPAELVPDLLEEDLEEgSLYDYLEER 80

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 502862563  169 KKLVIDRSEQELVPVMPSEEAIAALALDPAKPILEKVSRGFLKDGRVFEYSRNVFNTDDYK 229
Cdd:pfam07702  81 YGLPITRAEQTIEAVLADAEEAELLGISPGAPVLLIERVTYDQDGRPVEYSRSYYRGDRYR 141
UTRA smart00866
The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; ...
 90-229 8.03e-32

The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; It has a similar fold to HutC/FarR-like bacterial transcription factors of the GntR family. It is believed to modulate activity of bacterial transcription factors in response to binding small molecules.


Pssm-ID: 214869 [Multi-domain]  Cd Length: 143  Bit Score: 113.54  E-value: 8.03e-32
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502862563    90 DRNVDTHSDVKIFEVVKADTRLAATLAIGEDDKVWHVKRVRFIKQKPVNLEETWMPLAMFPDLTWEVMEKSKYHYVEQIK 169
Cdd:smart00866   1 AQGRKPTTKVLSFERVPADEELAEALGLPPGDPVYRIERLRLADGEPVALETTYLPAALFPGLLEEDLSGSLYEYLEERL 80

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 502862563   170 KLVI---DRSEQELVPVMPSEEAIAALALDPAKPILEKVSRGFLKDGRVFEYSRNVFNTDDYK 229
Cdd:smart00866  81 GLKIvrsTRAEQTITAVLADEEEAELLGLPPGAPLLVVERVTYDDDGRPVEYSRSYYRGDRFR 143
C_P_lyase_phnF TIGR02325
phosphonates metabolism transcriptional regulator PhnF; All members of the seed alignment for ...
 6-232 1.24e-29

phosphonates metabolism transcriptional regulator PhnF; All members of the seed alignment for this family are predicted helix-turn-helix transcriptional regulatory proteins of the broader gntR and are found associated with genes for the import and degradation of phosphonates and/or related compounds (e.g. phosphonites) with a direct C-P bond. [Transport and binding proteins, Anions, Regulatory functions, DNA interactions]


Pssm-ID: 131378 [Multi-domain]  Cd Length: 238  Bit Score: 110.64  E-value: 1.24e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502862563    6 RYRQIADVFREKINAGELKPGDALPTESSLQEAFSVSRVTVRQALKLLADEQIIESIQGSGSYVKEERVNYDIYQLTGFY 85
Cdd:TIGR02325   9 LWRQIADKIEQEIAAGHLRAGDYLPAEMQLAERFGVNRHTVRRAIAALVERGLLRAEQGRGTFVAARRIDYPLSARTRFS 88

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502862563   86 EKLADRNVDTHSDVKIFEVVKADTRLAATLAIGEDDKVWHVKRVRFIKQKPVNLEETWMPLAMFPDLTwEVMEKSKYHYV 165
Cdd:TIGR02325  89 QNLADQGREPTGELLLSDLEPASAELADALGLTVGAPLVRLETLRKADGRPLCRATTWFPAARFPGIG-QAYAASGSITD 167

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 502862563  166 EQIKKLVID--RSEQELVPVMPSEEAIAALALDPAKPILEKVSRGFLKDGRVFEYSRNVFNTDDYKFTL 232
Cdd:TIGR02325 168 ALREQGVADyrRSSTRISARHADAKDCARLELPPGRPLLVVQALNHDGEGRPVQYSVSRFRADRVEFTM 236
WHTH_GntR cd07377
Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional ...
 5-70 3.84e-25

Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; This CD represents the winged HTH DNA-binding domain of the GntR (named after the gluconate operon repressor in Bacillus subtilis) family of bacterial transcriptional regulators and their putative homologs found in eukaryota and archaea. The GntR family has over 6000 members distributed among almost all bacterial species, which is comprised of FadR, HutC, MocR, YtrA, AraR, PlmA, and other subfamilies for the regulation of the most varied biological process. The monomeric proteins of the GntR family are characterized by two function domains: a small highly conserved winged helix-turn-helix prokaryotic DNA binding domain in the N-terminus, and a very diverse regulatory ligand-binding domain in the C-terminus for effector-binding/oligomerization, which provides the basis for the subfamily classifications. Binding of the effector to GntR-like transcriptional regulators is presumed to result in a conformational change that regulates the DNA-binding affinity of the repressor. The GntR-like proteins bind as dimers, where each monomer recognizes a half-site of 2-fold symmetric DNA sequences.


Pssm-ID: 153418 [Multi-domain]  Cd Length: 66  Bit Score: 93.67  E-value: 3.84e-25
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 502862563   5 PRYRQIADVFREKINAGELKPGDALPTESSLQEAFSVSRVTVRQALKLLADEQIIESIQGSGSYVK 70
Cdd:cd07377    1 PLYEQIADQLREAILSGELKPGDRLPSERELAEELGVSRTTVREALRELEAEGLVERRPGRGTFVA 66
PRK11402 PRK11402
transcriptional regulator PhoB;
4-237 7.62e-23

transcriptional regulator PhoB;


Pssm-ID: 183118 [Multi-domain]  Cd Length: 241  Bit Score: 92.98  E-value: 7.62e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502862563   4 KPRYRQIADVFREKINAGELKPGDALPTESSLQEAFSVSRVTVRQALKLLADEQIIESIQGSGSYVKEERVNYDIYQLTG 83
Cdd:PRK11402   8 QLLYATVRQRLLDDIAQGVYQAGQQIPTENELCTQYNVSRITIRKAISDLVADGVLIRWQGKGTFVQSQKVENALLTVSG 87

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502862563  84 FYEKLADRNVDTHSDVKIFEVVKADTrLAATLAIGEDDKVWHVKRVRFIKQKPVNLEETWMPLAMFPDLTWEVMEKSKYH 163
Cdd:PRK11402  88 FTDFGVSQGKATKEKVIEQERVSAAP-FCEKLNIPGNSEVFHLCRVMYLDKEPLFIDSSWIPLSRYPDFDEIYVEGSSTY 166

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 502862563 164 YVEQIKKLVIDRSEQELVPVMPSEEAIAA-LALDPAKPILEKVSRGFLKDGRVFEYSRNVFNTDDYKFTLVAKRR 237
Cdd:PRK11402 167 QLFQERFDTRVVSDKKTIDIFAATRPEAKwLKCELGEPLFRISKIAFDQNDKPVHVSELFCRANRVTLTIDNKRH 241
PRK14999 PRK14999
histidine utilization repressor; Provisional
 5-230 3.92e-22

histidine utilization repressor; Provisional


Pssm-ID: 184961 [Multi-domain]  Cd Length: 241  Bit Score: 91.15  E-value: 3.92e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502862563   5 PRYRQIADVFREKINAGELKPGDALPTESSLQEAFSVSRVTVRQALKLLADEQIIESIQGSGSYVKEERVNYDIYQLTGF 84
Cdd:PRK14999  12 PFYETVKQDICKKIAGGVWQPHDRIPSEAELVAQYGFSRMTINRALRELTDEGWLVRLQGVGTFVAEPKGQSALFEVRSI 91

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502862563  85 YEKLADRNVDTHSDVKIFEVVKADTRLAATLAIGEDDKVWHVKRVRFIKQKPVNLEETWMPLAMFPD-LTWEVMEKSKYH 163
Cdd:PRK14999  92 AEEIAARRHQHRCEVLTLERVRANAIQASALNVNESDVIFHSIMVHYENDLPVQIEDRCVNADIAVDyLTQDYRQTTPHA 171

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 502862563 164 YVEQIKKLVidRSEQELVPVMPSEEAIAALALDPAKPILeKVSRGFLKDGRVFEYSRNVFNTDDYKF 230
Cdd:PRK14999 172 YLSRIAPLT--EGEHIVEAVRATAQECAWLTIKEHEPCL-LIRRTTWSASRIVSHARLLFPGSRYRL 235
FadR COG2186
DNA-binding transcriptional regulator, FadR family [Transcription];
1-71 1.49e-20

DNA-binding transcriptional regulator, FadR family [Transcription];


Pssm-ID: 441789 [Multi-domain]  Cd Length: 232  Bit Score: 86.53  E-value: 1.49e-20
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 502862563   1 MGNKPRYRQIADVFREKINAGELKPGDALPTESSLQEAFSVSRVTVRQALKLLADEQIIESIQGSGSYVKE 71
Cdd:COG2186    3 IRRRSLAEQVAEQLRELILSGELKPGDRLPSERELAEQLGVSRTTVREALRALEALGLVEVRQGGGTFVRE 73
GntR pfam00392
Bacterial regulatory proteins, gntR family; This family of regulatory proteins consists of the ...
 7-69 4.76e-20

Bacterial regulatory proteins, gntR family; This family of regulatory proteins consists of the N-terminal HTH region of GntR-like bacterial transcription factors. At the C-terminus there is usually an effector-binding/oligomerization domain. The GntR-like proteins include the following sub-families: MocR, YtrR, FadR, AraR, HutC and PlmA, DevA, DasR. Many of these proteins have been shown experimentally to be autoregulatory, enabling the prediction of operator sites and the discovery of cis/trans relationships. The DasR regulator has been shown to be a global regulator of primary metabolism and development in Streptomyces coelicolor.


Pssm-ID: 306822 [Multi-domain]  Cd Length: 64  Bit Score: 80.74  E-value: 4.76e-20
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 502862563    7 YRQIADVFREKINAGELKPGDALPTESSLQEAFSVSRVTVRQALKLLADEQIIESIQGSGSYV 69
Cdd:pfam00392   2 YEQVYARLREDILSGRLRPGDKLPSERELAAEFGVSRTTVREALRRLEAEGLVERRQGRGTFV 64
ARO8 COG1167
DNA-binding transcriptional regulator, MocR family, contains an aminotransferase domain ...
 2-73 3.32e-19

DNA-binding transcriptional regulator, MocR family, contains an aminotransferase domain [Transcription, Amino acid transport and metabolism]; DNA-binding transcriptional regulator, MocR family, contains an aminotransferase domain is part of the Pathway/BioSystem: Lysine biosynthesis


Pssm-ID: 440781 [Multi-domain]  Cd Length: 471  Bit Score: 85.65  E-value: 3.32e-19
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 502862563   2 GNKPRYRQIADVFREKINAGELKPGDALPTESSLQEAFSVSRVTVRQALKLLADEQIIESIQGSGSYVKEER 73
Cdd:COG1167    9 SSGPLYLQLADALREAILSGRLPPGDRLPSSRELAAQLGVSRSTVVRAYEELEAEGLIESRPGSGTFVAARL 80
HTH_GNTR smart00345
helix_turn_helix gluconate operon transcriptional repressor;
10-69 1.67e-17

helix_turn_helix gluconate operon transcriptional repressor;


Pssm-ID: 197669 [Multi-domain]  Cd Length: 60  Bit Score: 73.76  E-value: 1.67e-17
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 502862563    10 IADVFREKINAGELKPGDALPTESSLQEAFSVSRVTVRQALKLLADEQIIESIQGSGSYV 69
Cdd:smart00345   1 VAERLREDIVSGELRPGDKLPSERELAAQLGVSRTTVREALSRLEAEGLVQRRPGSGTFV 60
YhcF COG1725
DNA-binding transcriptional regulator YhcF, GntR family [Transcription];
3-71 1.99e-16

DNA-binding transcriptional regulator YhcF, GntR family [Transcription];


Pssm-ID: 441331 [Multi-domain]  Cd Length: 114  Bit Score: 72.52  E-value: 1.99e-16
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 502862563   3 NKPRYRQIADVFREKINAGELKPGDALPTESSLQEAFSVSRVTVRQALKLLADEQIIESIQGSGSYVKE 71
Cdd:COG1725    8 GVPIYEQIADQIKEAIASGELKPGDRLPSVRELAAELGVNPNTVAKAYRELEDEGLIETRRGKGTFVAE 76
GntR COG1802
DNA-binding transcriptional regulator, GntR family [Transcription];
9-71 1.13e-12

DNA-binding transcriptional regulator, GntR family [Transcription];


Pssm-ID: 441407 [Multi-domain]  Cd Length: 222  Bit Score: 64.94  E-value: 1.13e-12
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 502862563   9 QIADVFREKINAGELKPGDALpTESSLQEAFSVSRVTVRQALKLLADEQIIESIQGSGSYVKE 71
Cdd:COG1802   15 QVYEALREAILSGELPPGERL-SEAELAERLGVSRTPVREALRRLEAEGLVEIRPNRGARVAP 76
PRK09990 PRK09990
DNA-binding transcriptional regulator GlcC; Provisional
 8-69 4.90e-12

DNA-binding transcriptional regulator GlcC; Provisional


Pssm-ID: 182186 [Multi-domain]  Cd Length: 251  Bit Score: 63.63  E-value: 4.90e-12
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 502862563   8 RQIADVFREKINA----GELKPGDALPTESSLQEAFSVSRVTVRQALKLLADEQIIESIQGSGSYV 69
Cdd:PRK09990   6 RPIADVVAERIERlivdGVLKVGQALPSERRLCEKLGFSRSALREGLTVLRGRGIIETAQGRGSFV 71
PRK10079 PRK10079
phosphonate metabolism transcriptional regulator PhnF; Provisional
 6-154 8.02e-10

phosphonate metabolism transcriptional regulator PhnF; Provisional


Pssm-ID: 182227 [Multi-domain]  Cd Length: 241  Bit Score: 57.09  E-value: 8.02e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502862563   6 RYRQIADVFREKINaGELKPGDALPTESSLQEAFSVSRVTVRQALKLLADEQIIESIQGSGSYVKEERVNYDIYQLTGFY 85
Cdd:PRK10079  13 RYQEIAAKLEQELR-QHYRCGDYLPAEQQLAARYEVNRHTLRRAIDQLVEKGWVQRRQGVGVLVLMRPYDYPLNAQARFS 91

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 502862563  86 EKLADRNVDTHSDVKIFEVVKADTRLAATLAIGEDDKVWHVKRVRFIKQKPVNLEETWmplamFPDLTW 154
Cdd:PRK10079  92 QNLLDQGSHPTSEKLLSVLRPASGHVADALGITEGENVIHLRTLRRVNGVALCLIDHY-----FADLTW 155
PRK10421 PRK10421
DNA-binding transcriptional repressor LldR; Provisional
 9-72 9.01e-09

DNA-binding transcriptional repressor LldR; Provisional


Pssm-ID: 236690 [Multi-domain]  Cd Length: 253  Bit Score: 54.39  E-value: 9.01e-09
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 502862563   9 QIADVFREKINAGELKPGDALPTESSLQEAFSVSRVTVRQALKLLADEQIIESIQGSGSYVKEE 72
Cdd:PRK10421   6 EVADRVRALIEEKNLEAGMKLPAERQLAMQLGVSRNSLREALAKLVSEGVLLSRRGGGTFIRWR 69
PRK10225 PRK10225
Uxu operon transcriptional regulator;
7-116 2.04e-07

Uxu operon transcriptional regulator;


Pssm-ID: 182318 [Multi-domain]  Cd Length: 257  Bit Score: 50.40  E-value: 2.04e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502862563   7 YRQIADVFREKINAGELKPGDALPTESSLQEAFSVSRVTVRQALKLLADEQIIESIQGSGSYVKEERVNYDIyqltgfye 86
Cdd:PRK10225  11 YQEVGAMIRDLIIKTPYNPGERLPPEREIAEMLDVTRTVVREALIMLEIKGLVEVRRGAGIYVLDSSGSHNT-------- 82

                         90       100       110
                 ....*....|....*....|....*....|..
gi 502862563  87 kladRNVDTH--SDVKIFEVVKADTRLAATLA 116
Cdd:PRK10225  83 ----DSPDANvcNDAGPFELLQARQLLESNIA 110
PRK11523 PRK11523
transcriptional regulator ExuR;
7-69 2.90e-06

transcriptional regulator ExuR;


Pssm-ID: 183176 [Multi-domain]  Cd Length: 253  Bit Score: 46.76  E-value: 2.90e-06
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 502862563   7 YRQIADVFREKINAGELKPGDALPTESSLQEAFSVSRVTVRQALKLLADEQIIESIQGSGSYV 69
Cdd:PRK11523  10 YQQLAAELKERIEQGVYLVGDKLPAERFIADEKNVSRTVVREAIIMLEVEGYVEVRKGSGIHV 72
PRK03837 PRK03837
transcriptional regulator NanR; Provisional
 18-60 5.50e-06

transcriptional regulator NanR; Provisional


Pssm-ID: 235166 [Multi-domain]  Cd Length: 241  Bit Score: 46.17  E-value: 5.50e-06
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|...
gi 502862563  18 INAGELKPGDALPTESSLQEAFSVSRVTVRQALKLLADEQIIE 60
Cdd:PRK03837  26 IRSGEFGPGDQLPSERELMAFFGVGRPAVREALQALKRKGLVQ 68
pdhR PRK09464
pyruvate dehydrogenase complex transcriptional repressor PdhR;
4-72 6.00e-06

pyruvate dehydrogenase complex transcriptional repressor PdhR;


Pssm-ID: 181879 [Multi-domain]  Cd Length: 254  Bit Score: 46.17  E-value: 6.00e-06
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 502862563   4 KPRYRQIADVFREK----INAGELKPGDALPTESSLQEAFSVSRVTVRQALKLLADEQIIESIQGSGSYVKEE 72
Cdd:PRK09464   5 KIRQPKLSDVIEQQleflILEGTLRPGEKLPPERELAKQFDVSRPSLREAIQRLEAKGLLLRRQGGGTFVQSS 77
PRK15481 PRK15481
transcriptional regulatory protein PtsJ; Provisional
 9-71 7.80e-05

transcriptional regulatory protein PtsJ; Provisional


Pssm-ID: 185378 [Multi-domain]  Cd Length: 431  Bit Score: 43.11  E-value: 7.80e-05
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 502862563   9 QIADVFREKINAGELKPGDALPTESSLQEAFSVSRVTVRQALKLLADEQIIESIQGSGSYVKE 71
Cdd:PRK15481   9 EIFDSIRQLIQAGRLRPGDSLPPVRELASELGVNRNTVAAAYKRLVTAGLAQSQGRNGTVIRG 71
HTH_41 pfam14502
Helix-turn-helix domain;
24-69 1.31e-03

Helix-turn-helix domain;


Pssm-ID: 433997 [Multi-domain]  Cd Length: 48  Bit Score: 35.93  E-value: 1.31e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*...
gi 502862563   24 KPGDALPTESSLQEAFSVSRVTVRQALKLLADEQIIE-SIQG-SGSYV 69
Cdd:pfam14502   1 KAGERLPTISEYSHKFELSVGTVQKALKKLEDMKAIQlERRGhNGTYL 48
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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