|
Name |
Accession |
Description |
Interval |
E-value |
| PRK10490 |
PRK10490 |
sensor protein KdpD; Provisional |
1-895 |
0e+00 |
|
sensor protein KdpD; Provisional
Pssm-ID: 236701 [Multi-domain] Cd Length: 895 Bit Score: 1909.01 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502862580 1 MTDEPLRPDPDRLLEQTAEAHRGKLKIFFGACAGVGKTFAMLTEAQRLRAQGLDILIGVVETHGRKETAALLKGLATQPP 80
Cdd:PRK10490 1 MNNEPLRPDPDRLLEQTAEPHRGKLKIFFGACAGVGKTYAMLQEAQRLRAQGLDVLVGVVETHGRKETAALLEGLTVLPP 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502862580 81 RRISHRGRLVTEFDLDAALARRPALILMDELAHSNAPGSRHPKRWQDVEELLEAGIDVFTTVNVQHLESLNDVVSGVTGI 160
Cdd:PRK10490 81 KRIHHRGRHISEFDLDAALARRPALILMDELAHSNAPGSRHPKRWQDVEELLEAGIDVFTTVNVQHLESLNDVVGGVTGI 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502862580 161 QVRETVPDPFFDSADEVVLVDLPPDDLRQRLHEGKVYIAGQAERAIEHFFRKGNLIALRELALRRTADRVDDQMRAWRDL 240
Cdd:PRK10490 161 QVRETVPDPFFDAADEVVLVDLPPDDLRQRLNEGKVYIAGQAERAIEHFFRKGNLIALRELALRRTADRVDDQMRAWRDH 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502862580 241 QGQERVWHTRDAILLCIGHGSGNEKLVRTAARLAAKFGSVWHAVYVETPQLHALPENQRRAILSSLRLAQELGAETATLS 320
Cdd:PRK10490 241 QGEEKVWHTRDAILLCIGHNTGSEKLVRTAARLAARLGSVWHAVYVETPRLHRLPEKKRRAILSALRLAQELGAETATLS 320
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502862580 321 DPQEDKAILRYAREHNLGKIVIGRRQHRRWFSRESFADKLARRAPDLDLVVVALDDKPTPLPNRAPDSRTFTDKWRIQLR 400
Cdd:PRK10490 321 DPAEEKAVLRYAREHNLGKIIIGRRASRRWWRRESFADRLARLGPDLDLVIVALDEPPARAIAKAPDSRPFKEKWRVQIQ 400
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502862580 401 GCLIAVVLCALITFIASQWLIAFDAANLVMIYLLGVVVVALFYGRWPSVLATVINVISFDLFFIDPRGTLAVSDVQYVLT 480
Cdd:PRK10490 401 GCLVAIALCALITLIAMQWLPAFDAANLVMLYLLGVVVVALFYGRWPSVVATVINVASFDLFFVAPRGTLAVSDVQYLLT 480
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502862580 481 FAVMLTVGLVIGNLTAGVRYQARIARYREQRTRHLYEMSKSLAVGRTPLDIVQTSEQFIRSTFNASNLILLPDEHGKLRP 560
Cdd:PRK10490 481 FAVMLTVGLVIGNLTAGVRYQARVARYREQRTRHLYEMSKALAVGLSPEDIAATSEHFLASTFQARSQLLLPDDNGKLQP 560
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502862580 561 LTSATGMTPWDEAIARWSFDKGLPAGAGTDTLPGVPYQILPLRSADKNQGLVIVEPSNLRQLMIPEQQRLLETFTLLVAS 640
Cdd:PRK10490 561 LTHDQGMTPWDDAIARWSFDKGQPAGAGTDTLPGVPYQILPLKSAQKTYGLLAVEPGNLRQLMIPEQQRLLETFTLLIAN 640
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502862580 641 ALERLALTASEEQARLASERESIRNSLLAALSHDLRTPLTVLFGQSEILTLDLAAEGSKHALQASEIRQHVLNTTRLVNN 720
Cdd:PRK10490 641 ALERLTLTASEEQARLASEREQLRNALLAALSHDLRTPLTVLFGQAEILTLDLASEGSPHARQASEIRQQVLNTTRLVNN 720
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502862580 721 LLDMARIQSGGFNLKKEWLTLEEVVGSALKMLEPGLGGRHIALNMPDPLTLIHVDGPLFERVLINLLENAGKYAGAHAQI 800
Cdd:PRK10490 721 LLDMARIQSGGFNLRKEWLTLEEVVGSALQMLEPGLSGHPINLSLPEPLTLIHVDGPLFERVLINLLENAVKYAGAQAEI 800
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502862580 801 GVNASVEDHTLRLDVWDTGPGIPAGQEKAIFEKFSRGNKESAIPGVGLGLAICQAIIDVHGGTISAENRPEGGARFCVTL 880
Cdd:PRK10490 801 GIDAHVEGERLQLDVWDNGPGIPPGQEQLIFDKFARGNKESAIPGVGLGLAICRAIVEVHGGTIWAENRPEGGACFRVTL 880
|
890
....*....|....*
gi 502862580 881 PLDTPPELDELPEDL 895
Cdd:PRK10490 881 PLETPPELEEFHEDM 895
|
|
| KdpD |
pfam02702 |
Osmosensitive K+ channel His kinase sensor domain; This is a family of KdpD sensor kinase ... |
21-230 |
7.89e-140 |
|
Osmosensitive K+ channel His kinase sensor domain; This is a family of KdpD sensor kinase proteins that regulate the kdpFABC operon responsible for potassium transport. The aligned region corresponds to the N-terminal cytoplasmic part of the protein which functions as the sensor domain responsible for sensing turgor pressure. It recognizes C-di-AMP and K+ (Matilla et.al., FEMS Microbiology Reviews, fuab043, 45, 2021, 1. https://doi.org/10.1093/femsre/fuab043).
Pssm-ID: 460656 [Multi-domain] Cd Length: 210 Bit Score: 413.73 E-value: 7.89e-140
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502862580 21 HRGKLKIFFGACAGVGKTFAMLTEAQRLRAQGLDILIGVVETHGRKETAALLKGLATQPPRRISHRGRLVTEFDLDAALA 100
Cdd:pfam02702 1 RRGRLKIFLGAAPGVGKTYAMLQEAHRLKKRGVDVVIGYVETHGRPETEALLEGLEVIPRREIEYRGRTLEEMDLDAILA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502862580 101 RRPALILMDELAHSNAPGSRHPKRWQDVEELLEAGIDVFTTVNVQHLESLNDVVSGVTGIQVRETVPDPFFDSADEVVLV 180
Cdd:pfam02702 81 RRPEVVLVDELAHTNAPGSRHPKRWQDVEELLDAGIDVYTTVNIQHLESLNDVVEQITGVRVRETVPDSVLDRADEVELV 160
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|
gi 502862580 181 DLPPDDLRQRLHEGKVYIAGQAERAIEHFFRKGNLIALRELALRRTADRV 230
Cdd:pfam02702 161 DLTPEELLERLKEGKVYPPEKAERALKNFFRKGNLTALRELALRRVADRV 210
|
|
| KdpD |
COG2205 |
K+-sensing histidine kinase KdpD [Signal transduction mechanisms]; |
651-885 |
9.33e-76 |
|
K+-sensing histidine kinase KdpD [Signal transduction mechanisms];
Pssm-ID: 441807 [Multi-domain] Cd Length: 239 Bit Score: 247.13 E-value: 9.33e-76
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502862580 651 EEQARLASERESIRNSLLAALSHDLRTPLTVLFGQSEILTLDLAAEGSKHALQASEIRQHVLNTTRLVNNLLDMARIQSG 730
Cdd:COG2205 3 EEALEELEELERLKSEFLANVSHELRTPLTSILGAAELLLDEEDLSPEERRELLEIIRESAERLLRLIEDLLDLSRLESG 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502862580 731 GFNLKKEWLTLEEVVGSALKMLEPGLGGRHIALNM--PDPLTLIHVDGPLFERVLINLLENAGKYAGAHAQIGVNASVED 808
Cdd:COG2205 83 KLSLELEPVDLAELLEEAVEELRPLAEEKGIRLELdlPPELPLVYADPELLEQVLANLLDNAIKYSPPGGTITISARREG 162
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 502862580 809 HTLRLDVWDTGPGIPAGQEKAIFEKFSRGNKESAIPGVGLGLAICQAIIDVHGGTISAENRPEGGARFCVTLPLDTP 885
Cdd:COG2205 163 DGVRISVSDNGPGIPEEELERIFERFYRGDNSRGEGGTGLGLAIVKRIVEAHGGTIWVESEPGGGTTFTVTLPLAES 239
|
|
| BaeS |
COG0642 |
Signal transduction histidine kinase [Signal transduction mechanisms]; |
592-882 |
3.96e-58 |
|
Signal transduction histidine kinase [Signal transduction mechanisms];
Pssm-ID: 440407 [Multi-domain] Cd Length: 328 Bit Score: 202.45 E-value: 3.96e-58
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502862580 592 LPGVPYQILPLRSADKNQGLVIVEPSNLRQLMIPEQQRLLETFTLLVASALERLALTASEEQARLASERESIRNSLLAAL 671
Cdd:COG0642 38 LALLLLLLLLLLLLLLLALALLALLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLALLLLLEEANEAKSRFLANV 117
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502862580 672 SHDLRTPLTVLFGQSEILTLDLAAEGSKHAlqaSEIRQHVLNTTRLVNNLLDMARIQSGGFNLKKEWLTLEEVVGSALKM 751
Cdd:COG0642 118 SHELRTPLTAIRGYLELLLEELDEEQREYL---ETILRSADRLLRLINDLLDLSRLEAGKLELEPEPVDLAELLEEVVEL 194
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502862580 752 LEPGLGGRHIAL--NMPDPLTLIHVDGPLFERVLINLLENAGKYAGAHAQIGVNASVEDHTLRLDVWDTGPGIPAGQEKA 829
Cdd:COG0642 195 FRPLAEEKGIELelDLPDDLPTVRGDPDRLRQVLLNLLSNAIKYTPEGGTVTVSVRREGDRVRISVEDTGPGIPPEDLER 274
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|...
gi 502862580 830 IFEKFSRGNKESAIPGVGLGLAICQAIIDVHGGTISAENRPEGGARFCVTLPL 882
Cdd:COG0642 275 IFEPFFRTDPSRRGGGTGLGLAIVKRIVELHGGTIEVESEPGKGTTFTVTLPL 327
|
|
| WalK |
COG5002 |
Sensor histidine kinase WalK [Signal transduction mechanisms]; |
502-885 |
3.93e-56 |
|
Sensor histidine kinase WalK [Signal transduction mechanisms];
Pssm-ID: 444026 [Multi-domain] Cd Length: 390 Bit Score: 198.62 E-value: 3.93e-56
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502862580 502 ARIARYREQRTRHLYEMSKSLAVGRTPLDIVQTSEQFIRSTFNASNLILLPDEHGKLRPLTSATGMTPWDEAIARWSFDK 581
Cdd:COG5002 10 ALLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLALLLLLLLLLLLLLALLLLLLLLLLLLALALLLLALL 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502862580 582 GLPAGAGTDTLPGVPYQILPLRSADKNQGLVIVEPSNLRQLMIPEQQRLLETFTLLVASALERLALTASEEQarlaserE 661
Cdd:COG5002 90 LLLLLLLLLLALLILLLLLALLILLAALLLLLSELLLLLLLLGRLSLRLSALLLGLLLLAAVERDITELERL-------E 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502862580 662 SIRNSLLAALSHDLRTPLTVLFGQSEILTLDLAAEGSKHALQASEIRQHVLNTTRLVNNLLDMARIQSGGFNLKKEWLTL 741
Cdd:COG5002 163 QMRREFVANVSHELRTPLTSIRGYLELLLDGAADDPEERREYLEIILEEAERLSRLVNDLLDLSRLESGELKLEKEPVDL 242
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502862580 742 EEVVGSALKMLEPGLGGRHIAL--NMPDPLTLIHVDGPLFERVLINLLENAGKYAGAHAQIGVNASVEDHTLRLDVWDTG 819
Cdd:COG5002 243 AELLEEVVEELRPLAEEKGIELelDLPEDPLLVLGDPDRLEQVLTNLLDNAIKYTPEGGTITVSLREEDDQVRISVRDTG 322
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 502862580 820 PGIPAGQEKAIFEKFSRGNKE--SAIPGVGLGLAICQAIIDVHGGTISAENRPEGGARFCVTLPLDTP 885
Cdd:COG5002 323 IGIPEEDLPRIFERFYRVDKSrsRETGGTGLGLAIVKHIVEAHGGRIWVESEPGKGTTFTITLPLARE 390
|
|
| COG4251 |
COG4251 |
Bacteriophytochrome (light-regulated signal transduction histidine kinase) [Signal ... |
410-881 |
4.01e-42 |
|
Bacteriophytochrome (light-regulated signal transduction histidine kinase) [Signal transduction mechanisms];
Pssm-ID: 443393 [Multi-domain] Cd Length: 503 Bit Score: 161.49 E-value: 4.01e-42
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502862580 410 ALITFIASQWLIAFDAANLVMIYLLGVVVVALFYGRWPSVLATVINVISFDLFFIDPRGTLAVSDVQYVLTFAVMLTVGL 489
Cdd:COG4251 24 LLLVLLLALALLLLLALLVLLLLLIRLLLLLLLSLLALLLLLLLLLLLLLVLAALALLLLLLLLELALVLLALLLVLLLL 103
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502862580 490 VIGNLTAGVRYQARIARYREQRTRHLYEMSKSLAVGRTPLDIVQTSEQFIRSTFNASNLILLPDEHGKLRPLTSATGMTP 569
Cdd:COG4251 104 LALLLLLALLLLLELLLLLLALLLLLLLLALLLLEELALLRLALALLLLLLLLLLLLLLLLALILALLLAALAELELLLL 183
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502862580 570 WDEAIARWSFDKGLPAGAGTDTLPGVPYQILPLRSADKNQGLVIVEPSNLRQLMIPEQQRLLETFTLLVASALERLALTA 649
Cdd:COG4251 184 LLLVLLLLLLLLLLLLLLLLRLLLELLLLLEAELLLSLGGGLGLLLLLLLLLVLLLLLILLLLLLILVLELLELRLELEE 263
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502862580 650 SEEQARLASERESIRNSLLAAL----SHDLRTPLTVLFGQSEILTLDLAAEGSKHALQASE-IRQHVLNTTRLVNNLLDM 724
Cdd:COG4251 264 LEEELEERTAELERSNEELEQFayvaSHDLREPLRKISGFSQLLEEDYGDKLDEEGREYLErIRDAAERMQALIDDLLAY 343
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502862580 725 ARIQSGGfnLKKEWLTLEEVVGSALKMLEPGLGGRHIALNMpDPLTLIHVDGPLFERVLINLLENAGKYA--GAHAQIGV 802
Cdd:COG4251 344 SRVGRQE--LEFEPVDLNELLEEVLEDLEPRIEERGAEIEV-GPLPTVRGDPTLLRQVFQNLISNAIKYSrpGEPPRIEI 420
|
410 420 430 440 450 460 470
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 502862580 803 NASVEDHTLRLDVWDTGPGIPAGQEKAIFEKFSRGNKESAIPGVGLGLAICQAIIDVHGGTISAENRPEGGARFCVTLP 881
Cdd:COG4251 421 GAEREGGEWVFSVRDNGIGIDPEYAEKIFEIFQRLHSRDEYEGTGIGLAIVKKIVERHGGRIWVESEPGEGATFYFTLP 499
|
|
| NtrY |
COG5000 |
Signal transduction histidine kinase NtrY involved in nitrogen fixation and metabolism ... |
478-887 |
2.23e-40 |
|
Signal transduction histidine kinase NtrY involved in nitrogen fixation and metabolism regulation [Signal transduction mechanisms];
Pssm-ID: 444024 [Multi-domain] Cd Length: 422 Bit Score: 154.35 E-value: 2.23e-40
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502862580 478 VLTFAVMLTVGLV------IGNLTAGVR------YQARIARYREQRTRHLYE----MSKSLAVGRTPLDivqTSEQFIRS 541
Cdd:COG5000 18 LLLLALWLALLLArrltrpLRRLAEATRavaagdLSVRLPVTGDDEIGELARafnrMTDQLKEQREELE---ERRRYLET 94
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502862580 542 TF-NASNLILLPDEHGKLrpltsaTGMTPWDEAIARWSFDKGLPAGAGTDTLPGVPYQILPLRSADKNQGLVIVEPSNLR 620
Cdd:COG5000 95 ILeNLPAGVIVLDADGRI------TLANPAAERLLGIPLEELIGKPLEELLPELDLAELLREALERGWQEEIELTRDGRR 168
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502862580 621 QLMIpEQQRLLETFTLLVASALERLAltaseEQARLASEREsirnsLLAALSHDLRTPLTVLFGQSEILTLDLAAEGSKH 700
Cdd:COG5000 169 TLLV-RASPLRDDGYVIVFDDITELL-----RAERLAAWGE-----LARRIAHEIKNPLTPIQLSAERLRRKLADKLEED 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502862580 701 ALQASE----IRQHVLNTTRLVNNLLDMARIQSggfnLKKEWLTLEEVVGSALKMLEPGLGGRHIALNM--PDPLTLIHV 774
Cdd:COG5000 238 REDLERaldtIIRQVDRLKRIVDEFLDFARLPE----PQLEPVDLNELLREVLALYEPALKEKDIRLELdlDPDLPEVLA 313
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502862580 775 DGPLFERVLINLLENAGKYAGAHAQIGVNASVEDHTLRLDVWDTGPGIPAGQEKAIFE-KFSrgNKESaipGVGLGLAIC 853
Cdd:COG5000 314 DRDQLEQVLINLLKNAIEAIEEGGEIEVSTRREDGRVRIEVSDNGPGIPEEVLERIFEpFFT--TKPK---GTGLGLAIV 388
|
410 420 430
....*....|....*....|....*....|....
gi 502862580 854 QAIIDVHGGTISAENRPEGGARFCVTLPLDTPPE 887
Cdd:COG5000 389 KKIVEEHGGTIELESRPGGGTTFTIRLPLAEEAE 422
|
|
| COG4191 |
COG4191 |
Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal ... |
529-882 |
1.13e-39 |
|
Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal transduction mechanisms];
Pssm-ID: 443345 [Multi-domain] Cd Length: 361 Bit Score: 150.72 E-value: 1.13e-39
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502862580 529 LDIVQTSEQFIRSTFNASNLILLPDEHGKLRPLTSATGMTPWDEAIARWSFDKGLPAGAGTDTLPGVPYQILPLRSADKN 608
Cdd:COG4191 10 LLLALLRALALALALLLLLLLLLLALLLLLLALLLALLALLLLLLLLLLLLLLELLLLLLALLGGLLRLLLLLGLLLLLL 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502862580 609 QGLVIVEPSNLRQLMIPEQQRLLETFTLLVASALERLALTaseeQARLA-SER-ESIrNSLLAALSHDLRTPLTVLFGQS 686
Cdd:COG4191 90 LEALLLLLLAALDAEENAELEELERDITELERAEEELREL----QEQLVqSEKlAAL-GELAAGIAHEINNPLAAILGNA 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502862580 687 EILTLDLAAEGSKHALQ--ASEIRQHVLNTTRLVNNLLDMARIQSggfnLKKEWLTLEEVVGSALKMLEPGLGGRHIAL- 763
Cdd:COG4191 165 ELLRRRLEDEPDPEELReaLERILEGAERAAEIVRSLRAFSRRDE----EEREPVDLNELIDEALELLRPRLKARGIEVe 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502862580 764 -NMPDPLTLIHVDGPLFERVLINLLENAgKYA---GAHAQIGVNASVEDHTLRLDVWDTGPGIPAGQEKAIFEKF----S 835
Cdd:COG4191 241 lDLPPDLPPVLGDPGQLEQVLLNLLINA-IDAmeeGEGGRITISTRREGDYVVISVRDNGPGIPPEVLERIFEPFfttkP 319
|
330 340 350 360
....*....|....*....|....*....|....*....|....*..
gi 502862580 836 RGNkesaipGVGLGLAICQAIIDVHGGTISAENRPEGGARFCVTLPL 882
Cdd:COG4191 320 VGK------GTGLGLSISYGIVEKHGGRIEVESEPGGGTTFTITLPL 360
|
|
| USP_KdpD-like |
cd01987 |
USP domain of the osmosensitive K+ channel histidine kinase family; The KdpDE two component ... |
253-373 |
1.70e-38 |
|
USP domain of the osmosensitive K+ channel histidine kinase family; The KdpDE two component system is widespread in bacteria and archaea; it controls potassium homeostasis and virulence by regulating the transcription of multiple genes, including a kdpFABC operon, which encodes a high-affinity P-type ATPase transporter. The KdpD histidine kinase (HK, EC:2.7.13.3) contain an N-terminal sensory cytoplasmic region (NTR) composed of KdpD' and universal stress protein (USP) domains, a canonical transmembrane domain, and a cytoplasmic C-terminal region with a transmitter GAF domain and an EnvZ-like catalytic HK domain. Proteins containing the USP domain are induced by many environmental stressors such as nutrient starvation, drought, extreme temperatures, high salinity, and the presence of uncouplers, antibiotics, and metals. It enhances the rate of cell survival during prolonged exposure to such conditions, and may provide a general "stress endurance" activity.
Pssm-ID: 467491 [Multi-domain] Cd Length: 124 Bit Score: 139.30 E-value: 1.70e-38
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502862580 253 ILLCIGHGSGNEKLVRTAARLAAKFGSVWHAVYVETPQLHALPENQRRAILSSLRLAQELGAETATLSDPQEDKAILRYA 332
Cdd:cd01987 2 ILVCISSSPTSEKLIRRAARLAERLNGELTAVYVETPEESRLDEESQRRLLTNLKLAEELGAEVVSVEGDDVAEAIVEFA 81
|
90 100 110 120
....*....|....*....|....*....|....*....|...
gi 502862580 333 REHNLGKIVIGR--RQHRRWFSRESFADKLARRAPDLDLVVVA 373
Cdd:cd01987 82 RERNVTQIVLGQsrRRRWRRLFKGSLVDRLLREAPNIDVHIVP 124
|
|
| DUF4118 |
pfam13493 |
Domain of unknown function (DUF4118); This domain is found in a wide variety of bacterial ... |
403-508 |
7.86e-38 |
|
Domain of unknown function (DUF4118); This domain is found in a wide variety of bacterial signalling proteins. It is likely to be a transmembrane domain involved in ligand sensing.
Pssm-ID: 463897 Cd Length: 107 Bit Score: 136.82 E-value: 7.86e-38
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502862580 403 LIAVVLCALITFIASQWLIAFDAANLVMIYLLGVVVVALFYGRWPSVLATVINVISFDLFFIDPRGTLAVSDVQYVLTFA 482
Cdd:pfam13493 2 LLAVLILALATLLALLLRPLLPLANIALLFLLAVLLVALRGGRGPGLLAAVLSVLLFNYFFTPPYFTFTVSDPGYLLTLV 81
|
90 100
....*....|....*....|....*.
gi 502862580 483 VMLTVGLVIGNLTAGVRYQARIARYR 508
Cdd:pfam13493 82 VFLLVALLTSTLTARLRRQARQARRR 107
|
|
| HATPase |
cd00075 |
Histidine kinase-like ATPase domain; This superfamily includes the histidine kinase-like ... |
779-880 |
7.60e-33 |
|
Histidine kinase-like ATPase domain; This superfamily includes the histidine kinase-like ATPase (HATPase) domains of several ATP-binding proteins such as histidine kinase, DNA gyrase B, topoisomerases, heat shock protein 90 (HSP90), phytochrome-like ATPases and DNA mismatch repair proteins. Domains belonging to this superfamily are also referred to as GHKL (gyrase, heat-shock protein 90, histidine kinase, MutL) ATPase domains.
Pssm-ID: 340391 [Multi-domain] Cd Length: 102 Bit Score: 122.33 E-value: 7.60e-33
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502862580 779 FERVLINLLENAGKYAGAHAQIGVNASVEDHTLRLDVWDTGPGIPAGQEKAIFEKFSRGNKESAIPGVGLGLAICQAIID 858
Cdd:cd00075 1 LEQVLSNLLDNALKYSPPGGTIEISLRQEGDGVVLEVEDNGPGIPEEDLERIFERFYRGDKSREGGGTGLGLAIVRRIVE 80
|
90 100
....*....|....*....|..
gi 502862580 859 VHGGTISAENRPEGGARFCVTL 880
Cdd:cd00075 81 AHGGRITVESEPGGGTTFTVTL 102
|
|
| HATPase_c |
smart00387 |
Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases. |
775-882 |
2.58e-32 |
|
Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.
Pssm-ID: 214643 [Multi-domain] Cd Length: 111 Bit Score: 121.22 E-value: 2.58e-32
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502862580 775 DGPLFERVLINLLENAGKYAGAHAQIGVNASVEDHTLRLDVWDTGPGIPAGQEKAIFEKFSRG-NKESAIPGVGLGLAIC 853
Cdd:smart00387 2 DPDRLRQVLSNLLDNAIKYTPEGGRITVTLERDGDHVEITVEDNGPGIPPEDLEKIFEPFFRTdKRSRKIGGTGLGLSIV 81
|
90 100
....*....|....*....|....*....
gi 502862580 854 QAIIDVHGGTISAENRPEGGARFCVTLPL 882
Cdd:smart00387 82 KKLVELHGGEISVESEPGGGTTFTITLPL 110
|
|
| NtrB |
COG3852 |
Signal transduction histidine kinase NtrB, nitrogen specific [Signal transduction mechanisms]; |
597-887 |
1.36e-30 |
|
Signal transduction histidine kinase NtrB, nitrogen specific [Signal transduction mechanisms];
Pssm-ID: 443061 [Multi-domain] Cd Length: 361 Bit Score: 124.19 E-value: 1.36e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502862580 597 YQILPLRSADKNQGLVIVepsnLRQlmIPEQQRLletftllvasalerlaltasEEQARLASERESIRNsLLAALSHDLR 676
Cdd:COG3852 95 VSVSPLRDAEGEGGVLLV----LRD--ITERKRL--------------------ERELRRAEKLAAVGE-LAAGLAHEIR 147
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502862580 677 TPLTVLFGQSEILTLDLAAEGSKHALQasEIRQHVLNTTRLVNNLLDMARIQSggfnLKKEWLTLEEVVGSALKMLEPGL 756
Cdd:COG3852 148 NPLTGIRGAAQLLERELPDDELREYTQ--LIIEEADRLNNLVDRLLSFSRPRP----PEREPVNLHEVLERVLELLRAEA 221
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502862580 757 GGR-HIALNMPDPLTLIHVDGPLFERVLINLLENAGKYAGAHAQIGVNASVE----------DHTLRLDVWDTGPGIPAG 825
Cdd:COG3852 222 PKNiRIVRDYDPSLPEVLGDPDQLIQVLLNLVRNAAEAMPEGGTITIRTRVErqvtlgglrpRLYVRIEVIDNGPGIPEE 301
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 502862580 826 QEKAIFEKF--SRGNkesaipGVGLGLAICQAIIDVHGGTISAENRPEGGARFCVTLPLDTPPE 887
Cdd:COG3852 302 ILDRIFEPFftTKEK------GTGLGLAIVQKIVEQHGGTIEVESEPGKGTTFRIYLPLEQAEE 359
|
|
| PRK10549 |
PRK10549 |
two-component system sensor histidine kinase BaeS; |
626-889 |
1.44e-28 |
|
two-component system sensor histidine kinase BaeS;
Pssm-ID: 182539 [Multi-domain] Cd Length: 466 Bit Score: 120.12 E-value: 1.44e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502862580 626 EQQRLLETFTLLvASALERlaltaseeqarlaseRESIRNSLLAALSHDLRTPLTVLFGQSEIL---TLDLAAEgSKHAL 702
Cdd:PRK10549 218 ELGRLAQDFNQL-ASTLEK---------------NEQMRRDFMADISHELRTPLAVLRGELEAIqdgVRKFTPE-SVASL 280
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502862580 703 QAseirqHVLNTTRLVNNLLDMARIQSGGFNLKKEWLTLEEVVGSALKMLEPGLGGRHIAL--NMPDPLTLIHvDGPLFE 780
Cdd:PRK10549 281 QA-----EVGTLTKLVDDLHQLSLSDEGALAYRKTPVDLVPLLEVAGGAFRERFASRGLTLqlSLPDSATVFG-DPDRLM 354
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502862580 781 RVLINLLENAGKYAGAHAQIGVNASVEDHTLRLDVWDTGPGIPAGQEKAIFEKFSR--GNKESAIPGVGLGLAICQAIID 858
Cdd:PRK10549 355 QLFNNLLENSLRYTDSGGSLHISAEQRDKTLRLTFADSAPGVSDEQLQKLFERFYRteGSRNRASGGSGLGLAICLNIVE 434
|
250 260 270
....*....|....*....|....*....|.
gi 502862580 859 VHGGTISAENRPEGGARFCVTLPLDTPPELD 889
Cdd:PRK10549 435 AHNGRIIAAHSPFGGVSITVELPLERDLQRE 465
|
|
| HATPase_c |
pfam02518 |
Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the ... |
775-884 |
2.42e-27 |
|
Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the structurally related ATPase domains of histidine kinase, DNA gyrase B and HSP90.
Pssm-ID: 460579 [Multi-domain] Cd Length: 109 Bit Score: 107.07 E-value: 2.42e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502862580 775 DGPLFERVLINLLENAGKYAGAHAQIGVNASVEDHtLRLDVWDTGPGIPAGQEKAIFEKFSRGNKESAiPGVGLGLAICQ 854
Cdd:pfam02518 2 DELRLRQVLSNLLDNALKHAAKAGEITVTLSEGGE-LTLTVEDNGIGIPPEDLPRIFEPFSTADKRGG-GGTGLGLSIVR 79
|
90 100 110
....*....|....*....|....*....|
gi 502862580 855 AIIDVHGGTISAENRPEGGARFCVTLPLDT 884
Cdd:pfam02518 80 KLVELLGGTITVESEPGGGTTVTLTLPLAQ 109
|
|
| PRK09303 |
PRK09303 |
histidine kinase; |
650-881 |
1.28e-25 |
|
histidine kinase;
Pssm-ID: 236462 [Multi-domain] Cd Length: 380 Bit Score: 110.04 E-value: 1.28e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502862580 650 SEEQARLASERESIRNSL------LAALSHDLRTPLTVlfGQSEILTLDLAAEGSKHALQASEIRQ---HVLNTT----R 716
Cdd:PRK09303 131 SDELFVLRQENETLLEQLkfkdrvLAMLAHDLRTPLTA--ASLALETLELGQIDEDTELKPALIEQlqdQARRQLeeieR 208
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502862580 717 LVNNLLDMARIQSGGFNLKKEWLTLEEVVGSALKMLEPGLGGRHIALN--MPDPLTLIHVDGPLFERVLINLLENAGKYA 794
Cdd:PRK09303 209 LITDLLEVGRTRWEALRFNPQKLDLGSLCQEVILELEKRWLAKSLEIQtdIPSDLPSVYADQERIRQVLLNLLDNAIKYT 288
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502862580 795 GAHAQIGVnaSVEDHT---LRLDVWDTGPGIPAGQEKAIFEKFSRGNKESAIPGVGLGLAICQAIIDVHGGTISAENRPE 871
Cdd:PRK09303 289 PEGGTITL--SMLHRTtqkVQVSICDTGPGIPEEEQERIFEDRVRLPRDEGTEGYGIGLSVCRRIVRVHYGQIWVDSEPG 366
|
250
....*....|
gi 502862580 872 GGARFCVTLP 881
Cdd:PRK09303 367 QGSCFHFTLP 376
|
|
| PRK10604 |
PRK10604 |
sensor protein RstB; Provisional |
639-886 |
1.42e-24 |
|
sensor protein RstB; Provisional
Pssm-ID: 236724 [Multi-domain] Cd Length: 433 Bit Score: 107.77 E-value: 1.42e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502862580 639 ASALERLALT----ASEEQARLASeresiRNSLLAALSHDLRTPLTVLFGQSEILtlDLAAEGSKHALQaSEIRQhvLNT 714
Cdd:PRK10604 188 GSSLERLGVAfnqmADNINALIAS-----KKQLIDGIAHELRTPLVRLRYRLEMS--DNLSAAESQALN-RDIGQ--LEA 257
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502862580 715 trLVNNLLDMARIQSGGFNLKKEWLTLEEVVGSALKMLEPGLGGRHIALNMPDPLTLIHVDGPLFERVLINLLENAGKYA 794
Cdd:PRK10604 258 --LIEELLTYARLDRPQNELHLSEPDLPAWLSTHLADIQAVTPEKTVRLDTPHQGDYGALDMRLMERVLDNLLNNALRYA 335
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502862580 795 GAHAQIGvnASVEDHTLRLDVWDTGPGIPAGQEKAIFEKFSR--GNKESAIPGVGLGLAICQAIIDVHGGTISAENRPEG 872
Cdd:PRK10604 336 HSRVRVS--LLLDGNQACLIVEDDGPGIPPEERERVFEPFVRldPSRDRATGGCGLGLAIVHSIALAMGGSVNCDESELG 413
|
250
....*....|....*.
gi 502862580 873 GARFCVTLP--LDTPP 886
Cdd:PRK10604 414 GARFSFSWPvwHNLPQ 429
|
|
| PRK11100 |
PRK11100 |
sensory histidine kinase CreC; Provisional |
652-883 |
2.38e-24 |
|
sensory histidine kinase CreC; Provisional
Pssm-ID: 236846 [Multi-domain] Cd Length: 475 Bit Score: 107.62 E-value: 2.38e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502862580 652 EQARLASERESIRNSL---------LAALSHDLRTPLTVLFGQSEILTLDLAAEgsKHALQASEIRQHVLNTTRLVNNLL 722
Cdd:PRK11100 235 ELRELAQALESMRVKLegkayveqyVQTLTHELKSPLAAIRGAAELLQEDPPPE--DRARFTGNILTQSARLQQLIDRLL 312
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502862580 723 DMARIQSGGFNLKKEWLTLEEVVGSALKMLEPGLGGRHIALNMPDPLTLIHVDGPLFERVLINLLENAGKYAGAHAQIGV 802
Cdd:PRK11100 313 ELARLEQRQELEVLEPVALAALLEELVEAREAQAAAKGITLRLRPDDARVLGDPFLLRQALGNLLDNAIDFSPEGGTITL 392
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502862580 803 NASVEDHTLRLDVWDTGPGIPA-GQEKaIFEKF-SRGNKESAIPGVGLGLAICQAIIDVHGGTISAENRPEGGARFCVTL 880
Cdd:PRK11100 393 SAEVDGEQVALSVEDQGPGIPDyALPR-IFERFySLPRPANGRKSTGLGLAFVREVARLHGGEVTLRNRPEGGVLATLTL 471
|
...
gi 502862580 881 PLD 883
Cdd:PRK11100 472 PRH 474
|
|
| envZ |
PRK09467 |
osmolarity sensor protein; Provisional |
661-882 |
4.42e-24 |
|
osmolarity sensor protein; Provisional
Pssm-ID: 236531 [Multi-domain] Cd Length: 435 Bit Score: 106.15 E-value: 4.42e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502862580 661 ESIRNSLLAALSHDLRTPLTVLFGQSEILTL--DLAAEGSKHALQASE---------IRQHVLNTTRLV--NNLL-DMAR 726
Cdd:PRK09467 226 EDDRTLLMAGVSHDLRTPLTRIRLATEMMSEedGYLAESINKDIEECNaiieqfidyLRTGQEMPMEMAdlNALLgEVIA 305
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502862580 727 IQSGgfnlkkewltLEEVVGSALKMLEPGLGGRHIALnmpdpltlihvdgplfERVLINLLENAGKYAgaHAQIGVNASV 806
Cdd:PRK09467 306 AESG----------YEREIETALQPGPIEVPMNPIAI----------------KRALANLVVNAARYG--NGWIKVSSGT 357
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 502862580 807 EDHTLRLDVWDTGPGIPAGQEKAIFEKFSRGNKESAIPGVGLGLAICQAIIDVHGGTISAENRPEGGARFCVTLPL 882
Cdd:PRK09467 358 EGKRAWFQVEDDGPGIPPEQLKHLFQPFTRGDSARGSSGTGLGLAIVKRIVDQHNGKVELGNSEEGGLSARAWLPL 433
|
|
| HATPase_BaeS-like |
cd16946 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
779-881 |
6.02e-24 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli BasS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) similar to Escherichia coli BaeS HK of the BaeS/BaeR two-component regulatory system (TCS), which responds to envelope stress. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), and a HAMP sensory domain.
Pssm-ID: 340422 [Multi-domain] Cd Length: 109 Bit Score: 97.15 E-value: 6.02e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502862580 779 FERVLINLLENAGKYAGAHAQIGVNASVEDHTLRLDVWDTGPGIPAGQEKAIFEKFSR--GNKESAIPGVGLGLAICQAI 856
Cdd:cd16946 5 LQQLFVNLLENSLRYTDTGGKLRIRAAQTPQEVRLDVEDSAPGVSDDQLARLFERFYRveSSRNRASGGSGLGLAICHNI 84
|
90 100
....*....|....*....|....*
gi 502862580 857 IDVHGGTISAENRPEGGARFCVTLP 881
Cdd:cd16946 85 ALAHGGTISAEHSPLGGLRLVLTLP 109
|
|
| KinE |
COG5809 |
Sporulation sensor histidine kinase E [Cell cycle control, cell division, chromosome ... |
652-887 |
1.06e-23 |
|
Sporulation sensor histidine kinase E [Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];
Pssm-ID: 444511 [Multi-domain] Cd Length: 489 Bit Score: 105.83 E-value: 1.06e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502862580 652 EQARLASERESIRNSLLAALSHDLRTPLTVLFGQSEILTLDLAAEGSKHA-LQASEIRQhvLNTtrLVNNLLDMARIQSG 730
Cdd:COG5809 258 EELLRKSEKLSVVGELAAGIAHEIRNPLTSLKGFIQLLKDTIDEEQKTYLdIMLSELDR--IES--IISEFLVLAKPQAI 333
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502862580 731 GFNLKKewltLEEVVGSALKMLEPG--LGGRHIALNMPDPLTLIHVDGPLFERVLINLLENAGKYAGAHAQIGVNASVED 808
Cdd:COG5809 334 KYEPKD----LNTLIEEVIPLLQPQalLKNVQIELELEDDIPDILGDENQLKQVFINLLKNAIEAMPEGGNITIETKAED 409
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502862580 809 HT-LRLDVWDTGPGIPAGQEKAIFEKFSRgNKESaipGVGLGLAICQAIIDVHGGTISAENRPEGGARFCVTLPLDTPPE 887
Cdd:COG5809 410 DDkVVISVTDEGCGIPEERLKKLGEPFYT-TKEK---GTGLGLMVSYKIIEEHGGKITVESEVGKGTTFSITLPIKLSEQ 485
|
|
| PRK15347 |
PRK15347 |
two component system sensor kinase; |
643-887 |
2.83e-23 |
|
two component system sensor kinase;
Pssm-ID: 237951 [Multi-domain] Cd Length: 921 Bit Score: 106.26 E-value: 2.83e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502862580 643 ER-LALTASEEQARLASERESIRnslLAALSHDLRTPLTVLFGQSEIL---TLDLaaegSKHALqASEIRQHVLNTTRLV 718
Cdd:PRK15347 379 ERtQALAEAKQRAEQANKRKSEH---LTTISHEIRTPLNGVLGALELLqntPLTA----EQMDL-ADTARQCTLSLLAII 450
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502862580 719 NNLLDMARIQSGGFNLKKEWLTLEEVVGSA-----LKMLEPGLGGRHIaLNMPDPLTLiHVDGPLFERVLINLLENAGKY 793
Cdd:PRK15347 451 NNLLDFSRIESGQMTLSLEETALLPLLDQAmltiqGPAQSKSLTLRTF-VGAHVPLYL-HLDSLRLRQILVNLLGNAVKF 528
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502862580 794 AgAHAQIGVNASVEDHTLRLDVWDTGPGIPAGQEKAIFEKFSRGNKESAipGVGLGLAICQAIIDVHGGTISAENRPEGG 873
Cdd:PRK15347 529 T-ETGGIRLRVKRHEQQLCFTVEDTGCGIDIQQQQQIFTPFYQADTHSQ--GTGLGLTIASSLAKMMGGELTLFSTPGVG 605
|
250
....*....|....*.
gi 502862580 874 ARFCVTLPLD--TPPE 887
Cdd:PRK15347 606 SCFSLVLPLNeyAPPE 621
|
|
| HATPase_RstB-like |
cd16939 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
780-882 |
7.85e-23 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Salmonella typhimurium RstB; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Salmonella typhimurium RstB HK of the RstA-RstB two-component regulatory system (TCS), which regulates expression of the constituents participating in pyrimidine metabolism and iron acquisition, and may be required for regulation of Salmonella motility and invasion. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), and a HAMP sensor domain.
Pssm-ID: 340416 [Multi-domain] Cd Length: 104 Bit Score: 94.03 E-value: 7.85e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502862580 780 ERVLINLLENAGKYAgaHAQIGVNASVEDHTLRLDVWDTGPGIPAGQEKAIFEKFSR--GNKESAIPGVGLGLAICQAII 857
Cdd:cd16939 2 ARALDNLLRNALRYA--HRTVRIALLVSGGRLTLIVEDDGPGIPAAARERVFEPFVRldPSRDRATGGFGLGLAIVHRVA 79
|
90 100
....*....|....*....|....*
gi 502862580 858 DVHGGTISAENRPEGGARFCVTLPL 882
Cdd:cd16939 80 LWHGGHVECDDSELGGACFRLTWPR 104
|
|
| PRK11466 |
PRK11466 |
hybrid sensory histidine kinase TorS; Provisional |
643-885 |
3.31e-22 |
|
hybrid sensory histidine kinase TorS; Provisional
Pssm-ID: 236914 [Multi-domain] Cd Length: 914 Bit Score: 103.06 E-value: 3.31e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502862580 643 ERLALTASEEQARLASERES-IRNSLLAALSHDLRTPLTVLFGQSEILTLDLAAEGSKHALQAseIRQHVLNTTRLVNNL 721
Cdd:PRK11466 422 ELQELVIEHRQARAEAEKASqAKSAFLAAMSHEIRTPLYGILGTAQLLADNPALNAQRDDLRA--ITDSGESLLTILNDI 499
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502862580 722 LDMARIQSGGFN--LKKEWLTLEEVVGSALKMLEPGLGGRHIAL--NMPDPL-TLIHVDGPLFERVLINLLENAGKYAgA 796
Cdd:PRK11466 500 LDYSAIEAGGKNvsVSDEPFEPRPLLESTLQLMSGRVKGRPIRLatDIADDLpTALMGDPRRIRQVITNLLSNALRFT-D 578
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502862580 797 HAQIGVNASVEDHTLRLDVWDTGPGIPAGQEKAIFEKFSRGNKESAipGVGLGLAICQAIIDVHGGTISAENRPEGGARF 876
Cdd:PRK11466 579 EGSIVLRSRTDGEQWLVEVEDSGCGIDPAKLAEIFQPFVQVSGKRG--GTGLGLTISSRLAQAMGGELSATSTPEVGSCF 656
|
....*....
gi 502862580 877 CVTLPLDTP 885
Cdd:PRK11466 657 CLRLPLRVA 665
|
|
| HATPase_CpxA-like |
cd16949 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
779-882 |
3.66e-22 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli CpxA; This family includes the histidine kinase-like ATPase (HATPase) domains of two-component sensor histidine kinase (HKs) similar to Escherichia coli CpxA, HK of the CpxA-CpxR two-component regulatory system (TCS) which may function in acid stress and in cell wall stability. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and a HAMP sensor domain; some also contain a CpxA family periplasmic domain.
Pssm-ID: 340425 [Multi-domain] Cd Length: 104 Bit Score: 92.00 E-value: 3.66e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502862580 779 FERVLINLLENAGKYAgaHAQIGVNASVEDHTLRLDVWDTGPGIPAGQEKAIFEKFSRGN--KESAIPGVGLGLAICQAI 856
Cdd:cd16949 1 LARALENVLRNALRYS--PSKILLDISQDGDQWTITITDDGPGVPEDQLEQIFLPFYRVDsaRDRESGGTGLGLAIAERA 78
|
90 100
....*....|....*....|....*.
gi 502862580 857 IDVHGGTISAENRPEGGARFCVTLPL 882
Cdd:cd16949 79 IEQHGGKIKASNRKPGGLRVRIWLPA 104
|
|
| cztS_silS_copS |
TIGR01386 |
heavy metal sensor kinase; Members of this family contain a sensor histidine kinase domain ... |
669-881 |
4.93e-22 |
|
heavy metal sensor kinase; Members of this family contain a sensor histidine kinase domain (pfam00512) and a domain found in bacterial signal proteins (pfam00672). This group is separated phylogenetically from related proteins with similar architecture and contains a number of proteins associated with heavy metal resistance efflux systems for copper, silver, cadmium, and/or zinc.
Pssm-ID: 273593 [Multi-domain] Cd Length: 457 Bit Score: 100.15 E-value: 4.93e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502862580 669 AALSHDLRTPLTVLFGQSEI-LTLDLAAEGSKHALQASEIRQHVLntTRLVNNLLDMARIQSGGFNLKKEWLTLEEVVGS 747
Cdd:TIGR01386 246 ADLAHELRTPLTNLLGQTQVaLSQPRTGEEYREVLESNLEELERL--SRMVSDMLFLARADNGQLALERVRLDLAAELAK 323
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502862580 748 ALKMLEPGLGGRHIALNMPDPLTLiHVDGPLFERVLINLLENAGKYAGAHAQIGVNASVEDHTLRLDVWDTGPGIPAGQE 827
Cdd:TIGR01386 324 VAEYFEPLAEERGVRIRVEGEGLV-RGDPQMFRRAISNLLSNALRHTPDGGTITVRIERRSDEVRVSVSNPGPGIPPEHL 402
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*.
gi 502862580 828 KAIFEKFSRGN--KESAIPGVGLGLAICQAIIDVHGGTISAENrPEGGARFCVTLP 881
Cdd:TIGR01386 403 SRLFDRFYRVDpaRSNSGEGTGLGLAIVRSIMEAHGGRASAES-PDGKTRFILRFP 457
|
|
| HATPase_EvgS-ArcB-TorS-like |
cd16922 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases, many are hybrid ... |
782-882 |
1.19e-21 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases, many are hybrid sensor histidine kinases, similar to Escherichia coli EvgS, ArcB, TorS, BarA, RcsC; This family contains the histidine kinase-like ATPase (HATPase) domains of various two-component hybrid sensor histidine kinases (HKs), including the following Escherichia coli HKs: EvgS, a HK of the EvgS-EvgA two-component system (TCS) that confers acid resistance; ArcB, a HK of the ArcB-ArcA TCS that modulates the expression of numerous genes in response to respiratory growth conditions; TorS, a HK of the TorS-TorR TCS which is involved in the anaerobic utilization of trimethylamine-N-oxide; BarA, a HK of the BarA-UvrY TCS involved in the regulation of carbon metabolism; and RcsC, a HK of the RcsB-RcsC TCS which regulates the expression of the capsule operon and of the cell division gene ftsZ. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), with most having accessory sensor domain(s) such as GAF, PAS and CHASE; many are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.
Pssm-ID: 340399 [Multi-domain] Cd Length: 110 Bit Score: 90.63 E-value: 1.19e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502862580 782 VLINLLENAGKYAgAHAQIGVNASVEDHT-----LRLDVWDTGPGIPAGQEKAIFEKFSRGnkESAIP----GVGLGLAI 852
Cdd:cd16922 4 ILLNLLGNAIKFT-EEGEVTLRVSLEEEEedgvqLRFSVEDTGIGIPEEQQARLFEPFSQA--DSSTTrkygGTGLGLAI 80
|
90 100 110
....*....|....*....|....*....|
gi 502862580 853 CQAIIDVHGGTISAENRPEGGARFCVTLPL 882
Cdd:cd16922 81 SKKLVELMGGDISVESEPGQGSTFTFTLPL 110
|
|
| HATPase_TmoS-FixL-DctS-like |
cd16920 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
780-881 |
2.06e-21 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Rhizobium meliloti FixL, and Rhodobacter capsulatus DctS; includes hybrid sensor histidine kinase similar to Pseudomonas mendocina TmoS; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs), such as Pseudomonas mendocina TmoS HK of the TmoS-TmoT TCS, which controls the expression of the toluene-4-monooxygenase pathway, Rhizobium meliloti FixL HK of the FixL-FixJ TCS, which regulates the expression of the genes related to nitrogen fixation in the root nodule in response to O(2) levels, and Rhodobacter capsulatus DctS of the DctS-DctR TCS, which controls synthesis of the high-affinity C4-dicarboxylate transport system. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and PAS sensor domain(s); many are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.
Pssm-ID: 340397 [Multi-domain] Cd Length: 104 Bit Score: 89.76 E-value: 2.06e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502862580 780 ERVLINLLENagkyaGAHAQIGVNASVEDHTLR----------LDVWDTGPGIPAGQEKAIFEKFSRGNKEsaipGVGLG 849
Cdd:cd16920 2 QQVLINLVRN-----GIEAMSEGGCERRELTIRtspaddravtISVKDTGPGIAEEVAGQLFDPFYTTKSE----GLGMG 72
|
90 100 110
....*....|....*....|....*....|..
gi 502862580 850 LAICQAIIDVHGGTISAENRPEGGARFCVTLP 881
Cdd:cd16920 73 LSICRSIIEAHGGRLSVESPAGGGATFQFTLP 104
|
|
| HATPase_PhoQ-like |
cd16954 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
758-880 |
3.13e-21 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli PhoQ and Providencia stuartii AarG; This family includes histidine kinase-like ATPase (HATPase) domain of two-component sensor histidine kinases similar to Escherichia coli PhoQ and Providencia stuartii AarG. PhoQ is the histidine kinase (HK) of the PhoP-PhoQ two-component regulatory system (TCS), which responds to the levels of Mg2+ and Ca2+, controls virulence, mediates the adaptation to Mg2+-limiting environments, and regulates numerous cellular activities. Providencia stuartii AarG is a putative sensor kinase which controls the expression of the 2'-N-acetyltransferase and an intrinsic multiple antibiotic resistance (Mar) response in Providencia stuartii. The AarG product is similar to PhoQ in that it is able to restore wild-type levels of resistance to a Salmonella typhimurium phoQ mutant. However, the expression of the 2'-N-acetyltransferase gene and of aarP (a gene encoding a transcriptional activator of 2'-N-acetyltransferase) are not significantly affected by the levels of Mg2+ or Ca2+. Most proteins in this group contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some have an accessory HAMP sensor domain, and some have an intracellular membrane -interaction PhoQ sensor domain.
Pssm-ID: 340430 [Multi-domain] Cd Length: 135 Bit Score: 90.38 E-value: 3.13e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502862580 758 GRHIALNMPDPLTLIHVDGPLFErVLINLLENAGKYAgaHAQIGVNASVEDHTLRLDVWDTGPGIPAGQEKAIFEkfsRG 837
Cdd:cd16954 18 GVSISLDISPELRFPGERNDLME-LLGNLLDNACKWC--LEFVEVTARQTDGGLHLIVDDDGPGVPESQRSKIFQ---RG 91
|
90 100 110 120
....*....|....*....|....*....|....*....|....
gi 502862580 838 NK-ESAIPGVGLGLAICQAIIDVHGGTISAENRPEGGARFCVTL 880
Cdd:cd16954 92 QRlDEQRPGQGLGLAIAKEIVEQYGGELSLSDSPLGGARFEVVF 135
|
|
| PRK09959 |
PRK09959 |
acid-sensing system histidine kinase EvgS; |
616-883 |
1.57e-20 |
|
acid-sensing system histidine kinase EvgS;
Pssm-ID: 182169 [Multi-domain] Cd Length: 1197 Bit Score: 97.88 E-value: 1.57e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502862580 616 PSNLRQLMIPEQQRLLETFTLLVASALER-LALTASEEQARLaseresirnslLAALSHDLRTPLTVLFGQSEILT-LDL 693
Cdd:PRK09959 674 PASDHAVYICGWQDITETRDLIHALEVERnKAINATVAKSQF-----------LATMSHEIRTPISSIMGFLELLSgSGL 742
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502862580 694 AAEGSKHALQ-ASEIRQHVLNttrLVNNLLDMARIQSGGFNLKKEWLTLEEVVGSALKMLEPGLGGRHIALN----MPDP 768
Cdd:PRK09959 743 SKEQRVEAISlAYATGQSLLG---LIGEILDVDKIESGNYQLQPQWVDIPTLVQNTCHSFGAIAASKSIALScsstFPDH 819
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502862580 769 LtLIHVDGPLFERVLINLLENAGKYAGAHAqIGVNASV----EDHT-LRLDVWDTGPGIPAGQEKAIFEKFSRGNKESAI 843
Cdd:PRK09959 820 Y-LVKIDPQAFKQVLSNLLSNALKFTTEGA-VKITTSLghidDNHAvIKMTIMDSGSGLSQEEQQQLFKRYSQTSAGRQQ 897
|
250 260 270 280
....*....|....*....|....*....|....*....|
gi 502862580 844 PGVGLGLAICQAIIDVHGGTISAENRPEGGARFCVTLPLD 883
Cdd:PRK09959 898 TGSGLGLMICKELIKNMQGDLSLESHPGIGTTFTITIPVE 937
|
|
| HATPase_FilI-like |
cd16921 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
782-881 |
3.14e-20 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Methanosaeta harundinacea FilI and some hybrid sensor histidine kinases; This family includes FilI, the histidine kinase (HK) component of FilI-FilRs, a two-component signal transduction system (TCS) of the methanogenic archaeon, Methanosaeta harundinacea, which is involved in regulating methanogenesis. The cytoplasmic HK core consists of a C-terminal HK-like ATPase domain (represented here) and a histidine kinase dimerization and phosphoacceptor domain (HisKA) domain, which, in FilI, are coupled to CHASE, HAMP, PAS, and GAF sensor domains. FilI-FilRs catalyzes the phosphotransfer between FilI (HK) and FilRs (FilR1 and FilR2, response regulators) of the TCS. TCSs are predicted to be of bacterial origin, and acquired by archaea by horizontal gene transfer. This model also includes related HATPase domains such as that of Synechocystis sp. PCC6803 phytochrome-like protein Cph1. Proteins having this HATPase domain and HisKA domain also have accessory sensor domains such as CHASE, GAF, HAMP and PAS; some are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.
Pssm-ID: 340398 [Multi-domain] Cd Length: 105 Bit Score: 86.61 E-value: 3.14e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502862580 782 VLINLLENAGKYA--GAHAQIGVNASVEDHTLRLDVWDTGPGIPAGQEKAIFEKFSRGNKESAIPGVGLGLAICQAIIDV 859
Cdd:cd16921 4 VLTNLLGNAIKFRrpRRPPRIEVGAEDVGEEWTFYVRDNGIGIDPEYAEKVFGIFQRLHSREEYEGTGVGLAIVRKIIER 83
|
90 100
....*....|....*....|..
gi 502862580 860 HGGTISAENRPEGGARFCVTLP 881
Cdd:cd16921 84 HGGRIWLESEPGEGTTFYFTLP 105
|
|
| PRK11360 |
PRK11360 |
two-component system sensor histidine kinase AtoS; |
653-883 |
7.14e-20 |
|
two-component system sensor histidine kinase AtoS;
Pssm-ID: 236901 [Multi-domain] Cd Length: 607 Bit Score: 94.65 E-value: 7.14e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502862580 653 QARLASEREsirnsLLAALSHDLRTPLTVLFGQSEILTLDLAAEGSKHALqaSEIRQHVLNTTRLVNNLLDMARIQSggf 732
Cdd:PRK11360 384 QERLAALGE-----LVAGVAHEIRNPLTAIRGYVQIWRQQTSDPPSQEYL--SVVLREVDRLNKVIDQLLEFSRPRE--- 453
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502862580 733 nLKKEWLTLEEVVGSALKMLEPGLGGRHIALNM---PDpLTLIHVDGPLFERVLINLLENAGKYAGAHAQIGVNASVE-D 808
Cdd:PRK11360 454 -SQWQPVSLNALVEEVLQLFQTAGVQARVDFETeldNE-LPPIWADPELLKQVLLNILINAVQAISARGKIRIRTWQYsD 531
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 502862580 809 HTLRLDVWDTGPGIPAGQEKAIFEKFSRgNKESaipGVGLGLAICQAIIDVHGGTISAENRPEGGARFCVTLPLD 883
Cdd:PRK11360 532 GQVAVSIEDNGCGIDPELLKKIFDPFFT-TKAK---GTGLGLALSQRIINAHGGDIEVESEPGVGTTFTLYLPIN 602
|
|
| HATPase_TutC-TodS-like |
cd16925 |
Histidine kinase-like ATPase domain of hybrid sensor histidine kinases similar to Pseudomonas ... |
779-881 |
9.96e-20 |
|
Histidine kinase-like ATPase domain of hybrid sensor histidine kinases similar to Pseudomonas putida TodS and Thauera aromatica TutC; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component hybrid sensor histidine kinase (HKs) such Pseudomonas putida TodS HK of the TodS-TodT two-component regulatory system (TCS) which controls the expression of a toluene degradation pathway. Thauera aromatica TutC may be part of a TCS that is involved in anaerobic toluene metabolism. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), PAS sensor domain(s) and a REC domain.
Pssm-ID: 340402 [Multi-domain] Cd Length: 110 Bit Score: 85.24 E-value: 9.96e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502862580 779 FERVLINLLENAGKYAGAHAQIGVNASVED-HTLRLDVWDTGPGIPAGQEKAIFEKFSRGNKES--AIPGVGLGLAICQA 855
Cdd:cd16925 5 YERVVLNLLSNAFKFTPDGGRIRCILEKFRlNRFLLTVSDSGPGIPPNLREEIFERFRQGDGSStrAHGGTGLGLSIVKE 84
|
90 100
....*....|....*....|....*.
gi 502862580 856 IIDVHGGTISAENRPEGGARFCVTLP 881
Cdd:cd16925 85 FVELHGGTVTVSDAPGGGALFQVELP 110
|
|
| HATPase_EnvZ-like |
cd16950 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
781-881 |
1.51e-19 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli EnvZ and Pseudomonas aeruginosa BfmS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Escherichia coli EnvZ of the EnvZ-OmpR two-component regulatory system (TCS), which functions in osmoregulation. It also contains the HATPase domain of Pseudomonas aeruginosa BfmS, the HK of the BfmSR TCS, which functions in the regulation of the rhl quorum-sensing system and bacterial virulence in P. aeruginosa. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and a HAMP sensor domain; some also contain a periplasmic domain.
Pssm-ID: 340426 [Multi-domain] Cd Length: 101 Bit Score: 84.42 E-value: 1.51e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502862580 781 RVLINLLENAGKYAGAhaQIGVNASVEDHTLRLDVWDTGPGIPAGQEKAIFEKFSRGNKESAIPGVGLGLAICQAIIDVH 860
Cdd:cd16950 3 RVLSNLVDNALRYGGG--WVEVSSDGEGNRTRIQVLDNGPGIAPEEVDELFQPFYRGDNARGTSGTGLGLAIVQRISDAH 80
|
90 100
....*....|....*....|.
gi 502862580 861 GGTISAENRPEGGARFCVTLP 881
Cdd:cd16950 81 GGSLTLANRAGGGLCARIELP 101
|
|
| PRK10755 |
PRK10755 |
two-component system sensor histidine kinase PmrB; |
613-881 |
2.90e-19 |
|
two-component system sensor histidine kinase PmrB;
Pssm-ID: 236751 [Multi-domain] Cd Length: 356 Bit Score: 90.41 E-value: 2.90e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502862580 613 IVEPsnLRQLMIPEQQRLLETFTLLV--ASALERLALTASEEQ--ARLAserESIRNSLL--AALSHDLRTPLTVLFgqs 686
Cdd:PRK10755 85 ITRP--LAELQKELEARTADNLTPIAihSSTLEIEAVTSALNQlvSRLT---STLDQERLftADVAHELRTPLAGIR--- 156
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502862580 687 eiLTLDLAAEgsKHALQASEIRQHVLNTTRLVNNLLDMARIQ---SGGFNLKKEWLtlEEVVGSALKMLEPGLGGRHIAL 763
Cdd:PRK10755 157 --LHLELLEK--QHHIDVAPLIARLDQMMHTVEQLLQLARAGqsfSSGHYQTVKLL--EDVILPSQDELSEMLEQRQQTL 230
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502862580 764 NMPDPLTLIHV--DGPLFERVLINLLENAGKYAGAHAQIGVNASVEDHTLRLDVWDTGPGIPAGQEKAIFEKFSRgnKES 841
Cdd:PRK10755 231 LLPESAADITVqgDATLLRLLLRNLVENAHRYSPEGSTITIKLSQEDGGAVLAVEDEGPGIDESKCGELSKAFVR--MDS 308
|
250 260 270 280
....*....|....*....|....*....|....*....|.
gi 502862580 842 AIPGVGLGLAICQAIIDVHGGTISAENRPE-GGARFCVTLP 881
Cdd:PRK10755 309 RYGGIGLGLSIVSRITQLHHGQFFLQNRQErSGTRAWVWLP 349
|
|
| PRK10364 |
PRK10364 |
two-component system sensor histidine kinase ZraS; |
659-883 |
1.50e-18 |
|
two-component system sensor histidine kinase ZraS;
Pssm-ID: 236674 [Multi-domain] Cd Length: 457 Bit Score: 89.46 E-value: 1.50e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502862580 659 ERESIRNSLLAAL-------SHDLRTPLTVLFGQSEILTLDLAAEGSKHAL---QASEIRQhvLNttRLVNNLLDMARIQ 728
Cdd:PRK10364 225 QDEMKRKEKLVALghlaagvAHEIRNPLSSIKGLAKYFAERAPAGGEAHQLaqvMAKEADR--LN--RVVSELLELVKPT 300
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502862580 729 sggfNLKKEWLTLEEVVGSALKMLEPGLGGRHIALNM--PDPLTLIHVDGPLFERVLINLLENAGKYAGAHAQIGVNASV 806
Cdd:PRK10364 301 ----HLALQAVDLNDLINHSLQLVSQDANSREIQLRFtaNDTLPEIQADPDRLTQVLLNLYLNAIQAIGQHGVISVTASE 376
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 502862580 807 EDHTLRLDVWDTGPGIPAGQEKAIFEKFSRGNKEsaipGVGLGLAICQAIIDVHGGTISAENRPEGGARFCVTLPLD 883
Cdd:PRK10364 377 SGAGVKISVTDSGKGIAADQLEAIFTPYFTTKAE----GTGLGLAVVHNIVEQHGGTIQVASQEGKGATFTLWLPVN 449
|
|
| CitA |
COG3290 |
Sensor histidine kinase DipB regulating citrate/malate metabolism [Signal transduction ... |
759-883 |
4.98e-18 |
|
Sensor histidine kinase DipB regulating citrate/malate metabolism [Signal transduction mechanisms];
Pssm-ID: 442519 [Multi-domain] Cd Length: 389 Bit Score: 87.21 E-value: 4.98e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502862580 759 RHIALNM--PDPLTLIHVDGPLFERVLINLLENA----GKYAGAHAQIGVNASVEDHTLRLDVWDTGPGIPAGQEKAIFE 832
Cdd:COG3290 260 RGIDLTIdiDSDLPDLPLSDTDLVTILGNLLDNAieavEKLPEEERRVELSIRDDGDELVIEVEDSGPGIPEELLEKIFE 339
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|...
gi 502862580 833 K--FSRGNKESaipgvGLGLAICQAIIDVHGGTISAENRPEGGARFCVTLPLD 883
Cdd:COG3290 340 RgfSTKLGEGR-----GLGLALVKQIVEKYGGTIEVESEEGEGTVFTVRLPKE 387
|
|
| marine_sort_HK |
TIGR03785 |
proteobacterial dedicated sortase system histidine kinase; This histidine kinase protein is ... |
654-881 |
1.18e-17 |
|
proteobacterial dedicated sortase system histidine kinase; This histidine kinase protein is paired with an adjacent response regulator (TIGR03787) gene. It co-occurs with a variant sortase enzyme (TIGR03784), usually in the same gene neighborhood, in proteobacterial species most of which are marine, and with an LPXTG motif-containing sortase target conserved protein (TIGR03788). Sortases and LPXTG proteins are far more common in Gram-positive bacteria, where sortase systems mediate attachment to the cell wall or cross-linking of pilin structures. We give this predicted sensor histidine kinase the gene symbol psdS, for Proteobacterial Dedicated Sortase system Sensor histidine kinase.
Pssm-ID: 163497 [Multi-domain] Cd Length: 703 Bit Score: 87.88 E-value: 1.18e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502862580 654 ARLASERESIRNsLLAALSHDLRTPLTVLfgQSEILTLDLAAEGSKHALQASEIRQHVLNTTRLVNNLLDMARIQSGGFN 733
Cdd:TIGR03785 476 ARLRQYTHYLEN-MSSRLSHELRTPVAVV--RSSLENLELQALEQEKQKYLERAREGTERLSMILNNMSEATRLEQAIQS 552
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502862580 734 LKKEWLTLEEVVGSALKMLEPGLGGRHIALNMPDPLTLIHVDGPLFERVLINLLENAGKYAGAHAQIGVNASVEDHTLRL 813
Cdd:TIGR03785 553 AEVEDFDLSEVLSGCMQGYQMTYPPQRFELNIPETPLVMRGSPELIAQMLDKLVDNAREFSPEDGLIEVGLSQNKSHALL 632
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 502862580 814 DVWDTGPGIPAGQEKAIFEKF--SRGNKESAIPGVGLGLAICQAIIDVHGGTISAENRPEG-GARFCVTLP 881
Cdd:TIGR03785 633 TVSNEGPPLPEDMGEQLFDSMvsVRDQGAQDQPHLGLGLYIVRLIADFHQGRIQAENRQQNdGVVFRISLP 703
|
|
| KinA |
COG5805 |
Sporulation sensor histidine kinase A (Stage II sporulation protein SpoIIF/SpoIIJ) [Cell cycle ... |
649-882 |
1.62e-17 |
|
Sporulation sensor histidine kinase A (Stage II sporulation protein SpoIIF/SpoIIJ) [Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];
Pssm-ID: 444507 [Multi-domain] Cd Length: 496 Bit Score: 86.71 E-value: 1.62e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502862580 649 ASEEQARlaSERESIRNSLLAALSHDLRTPLTVLFGqseILTLDLA-AEGSKHALQA--SEIRQhvLNTtrLVNNLLDMA 725
Cdd:COG5805 274 AEELMAR--SEKLSIAGQLAAGIAHEIRNPLTSIKG---FLQLLQPgIEDKEEYFDImlSELDR--IES--IISEFLALA 344
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502862580 726 RIQSGGF---NLKKewlTLEEVVgsALKMLEPGLGGRHIALNMPDPLTLIHVDGPLFERVLINLLENA-------GKyag 795
Cdd:COG5805 345 KPQAVNKekeNINE---LIQDVV--TLLETEAILHNIQIRLELLDEDPFIYCDENQIKQVFINLIKNAieampngGT--- 416
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502862580 796 ahaqIGVNASVEDHTLRLDVWDTGPGIPAGQEKAIFEKFSRgNKESaipGVGLGLAICQAIIDVHGGTISAENRPEGGAR 875
Cdd:COG5805 417 ----ITIHTEEEDNSVIIRVIDEGIGIPEERLKKLGEPFFT-TKEK---GTGLGLMVSYKIIENHNGTIDIDSKVGKGTT 488
|
....*..
gi 502862580 876 FCVTLPL 882
Cdd:COG5805 489 FTITLPL 495
|
|
| HATPase_BasS-like |
cd16940 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
772-875 |
2.98e-17 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli BasS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) similar to Escherichia coli BasS HK of the BasS-BasR two-component regulatory system (TCS). Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some contain a HAMP sensory domain, while some an N-terminal two-component sensor kinase domain.
Pssm-ID: 340417 [Multi-domain] Cd Length: 113 Bit Score: 78.22 E-value: 2.98e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502862580 772 IHVDGPLFERVLINLLENAGKYAGAHAQIGVNASVEDHTLrLDVWDTGPGIPAGQEKAIFEKFSRGNKESAiPGVGLGLA 851
Cdd:cd16940 7 VQGDALLLFLLLRNLVDNAVRYSPQGSRVEIKLSADDGAV-IRVEDNGPGIDEEELEALFERFYRSDGQNY-GGSGLGLS 84
|
90 100
....*....|....*....|....
gi 502862580 852 ICQAIIDVHGGTISAENRPEGGAR 875
Cdd:cd16940 85 IVKRIVELHGGQIFLGNAQGGGLE 108
|
|
| HATPase_AtoS-like |
cd16943 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
777-882 |
3.95e-17 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli K-12 AtoS; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs) such as Escherichia coli AtoS, an HK of the AtoS-AtoC TCS. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some have accessory domains such as HAMP or PAS sensor domains or CBS-pair domains.
Pssm-ID: 340419 [Multi-domain] Cd Length: 105 Bit Score: 77.85 E-value: 3.95e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502862580 777 PLFERVLINLLENAGKYAGAHAQIGVNASVEDHTLRLDVWDTGPGIPAGQEKAIFEKF--SRGNKEsaipGVGLGLAICQ 854
Cdd:cd16943 2 SQLNQVLLNLLVNAAQAMEGRGRITIRTWAHVDQVLIEVEDTGSGIDPEILGRIFDPFftTKPVGE----GTGLGLSLSY 77
|
90 100
....*....|....*....|....*...
gi 502862580 855 AIIDVHGGTISAENRPEGGARFCVTLPL 882
Cdd:cd16943 78 RIIQKHGGTIRVASVPGGGTRFTIILPI 105
|
|
| PRK09835 |
PRK09835 |
Cu(+)/Ag(+) sensor histidine kinase; |
642-881 |
5.89e-17 |
|
Cu(+)/Ag(+) sensor histidine kinase;
Pssm-ID: 182101 [Multi-domain] Cd Length: 482 Bit Score: 84.82 E-value: 5.89e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502862580 642 LERLALTASEEQARLasERESIRNSLLAA-LSHDLRTPLTVLFGQSEILtldLAAEGSKHALQA---SEIRQHVlNTTRL 717
Cdd:PRK09835 241 LEQLVLSFNHMIERI--EDVFTRQSNFSAdIAHEIRTPITNLITQTEIA---LSQSRSQKELEDvlySNLEELT-RMAKM 314
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502862580 718 VNNLLDMARIQSGGFNLKKEWLTLEEVVGSALKMLEPGLGGRHIALNMPDPLTLIHVDGPLFERVLINLLENAGKYAGAH 797
Cdd:PRK09835 315 VSDMLFLAQADNNQLIPEKKMLDLADEVGKVFDFFEAWAEERGVELRFVGDPCQVAGDPLMLRRAISNLLSNALRYTPAG 394
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502862580 798 AQIGVNASVEDHTLRLDVWDTGPGIPAGQEKAIFEKFSRGN--KESAIPGVGLGLAICQAIIDVHGGTISAENRPEgGAR 875
Cdd:PRK09835 395 EAITVRCQEVDHQVQLVVENPGTPIAPEHLPRLFDRFYRVDpsRQRKGEGSGIGLAIVKSIVVAHKGTVAVTSDAR-GTR 473
|
....*.
gi 502862580 876 FCVTLP 881
Cdd:PRK09835 474 FVISLP 479
|
|
| PRK10337 |
PRK10337 |
sensor protein QseC; Provisional |
673-880 |
4.26e-16 |
|
sensor protein QseC; Provisional
Pssm-ID: 182388 [Multi-domain] Cd Length: 449 Bit Score: 82.00 E-value: 4.26e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502862580 673 HDLRTPLTVLFGQSEILTL---DLAAEgsKHALQasEIRQHVLNTTRLVNNLLDMARIQSGGFNLKKEWLTLEEVVGSAL 749
Cdd:PRK10337 246 HELRSPLAALKVQTEVAQLsddDPQAR--KKALL--QLHAGIDRATRLVDQLLTLSRLDSLDNLQDVAEIPLEDLLQSAV 321
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502862580 750 -KMLEPG-LGGRHIALNMPDPlTLIHVDGPLFERVLI-NLLENAGKY--AGAHAQIGVNASvedhtlRLDVWDTGPGIPA 824
Cdd:PRK10337 322 mDIYHTAqQAGIDVRLTLNAH-PVIRTGQPLLLSLLVrNLLDNAIRYspQGSVVDVTLNAR------NFTVRDNGPGVTP 394
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*.
gi 502862580 825 GQEKAIFEKFSRGNKESAiPGVGLGLAICQAIIDVHGGTISAENRPEGGarFCVTL 880
Cdd:PRK10337 395 EALARIGERFYRPPGQEA-TGSGLGLSIVRRIAKLHGMNVSFGNAPEGG--FEAKV 447
|
|
| cpxA |
PRK09470 |
envelope stress sensor histidine kinase CpxA; |
640-885 |
7.42e-16 |
|
envelope stress sensor histidine kinase CpxA;
Pssm-ID: 236532 [Multi-domain] Cd Length: 461 Bit Score: 81.13 E-value: 7.42e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502862580 640 SALERLALTaseeQARLASEresirnsllaaLSHDLRTPLTVLfgQseiLTLDLAA--EGSKHALQASEIRQHVLNTtrL 717
Cdd:PRK09470 234 TALERMMTS----QQRLLSD-----------ISHELRTPLTRL--Q---LATALLRrrQGESKELERIETEAQRLDS--M 291
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502862580 718 VNNLLDMARIQSGGfNLKKEWLTLEEVVGSALKMLEPGLGGRHIALNMPDPLTLIHVDG--PLFERVLINLLENAGKYAg 795
Cdd:PRK09470 292 INDLLVLSRNQQKN-HLERETFKANSLWSEVLEDAKFEAEQMGKSLTVSAPPGPWPINGnpNALASALENIVRNALRYS- 369
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502862580 796 aHAQIGVNASVEDHTLRLDVWDTGPGIPAGQEKAIFEKFSR----GNKESAipGVGLGLAICQAIIDVHGGTISAENRPE 871
Cdd:PRK09470 370 -HTKIEVAFSVDKDGLTITVDDDGPGVPEEEREQIFRPFYRvdeaRDRESG--GTGLGLAIVENAIQQHRGWVKAEDSPL 446
|
250
....*....|....
gi 502862580 872 GGARFCVTLPLDTP 885
Cdd:PRK09470 447 GGLRLTIWLPLYKR 460
|
|
| HATPase_VanS-like |
cd16923 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
781-881 |
1.12e-15 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Enterococcus faecium VanS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Enterococcus faecium VanS HK of the VanS-VanR two-component regulatory system (TCS) which activates the transcription of vanH, vanA and vanX vancomycin resistance genes. It also contains Ecoli YedV and PcoS, probable members of YedW-YedV TCS and PcoS-PcoR TCS, repectively. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); most also have a HAMP sensor domain.
Pssm-ID: 340400 [Multi-domain] Cd Length: 102 Bit Score: 73.57 E-value: 1.12e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502862580 781 RVLINLLENAGKYAGAHAQIGVNASVEDHTLRLDVWDTGPGIPAGQEKAIFEKFSRGNKESAIPGVGLGLAICQAIIDVH 860
Cdd:cd16923 3 RVFSNLLSNAIKYSPENTRIYITSFLTDDVVNIMFKNPSSHPLDFKLEKLFERFYRGDNSRNTEGAGLGLSIAKAIIELH 82
|
90 100
....*....|....*....|.
gi 502862580 861 GGTISAENRPEGGArFCVTLP 881
Cdd:cd16923 83 GGSASAEYDDNHDL-FKVRLP 102
|
|
| PRK10815 |
PRK10815 |
two-component system sensor histidine kinase PhoQ; |
656-879 |
1.69e-15 |
|
two-component system sensor histidine kinase PhoQ;
Pssm-ID: 182754 [Multi-domain] Cd Length: 485 Bit Score: 80.06 E-value: 1.69e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502862580 656 LASERE---SIRNSLlAALSHDLRTPLTVLfgQSEILTL----DLAAEGSKHAL--QASEIRQHVlnttrlvNNLLDMAR 726
Cdd:PRK10815 256 LKNERErytKYRTTL-TDLTHSLKTPLAVL--QSTLRSLrsgkQMSVEQAEPIMleQISRISQQI-------GYYLHRAS 325
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502862580 727 IQSGGFNLKKEwltLEEVVG------SAL-KMLEPGlgGRHIALNMPDPLTLI--HVDgplFERVLINLLENAGKYAGAH 797
Cdd:PRK10815 326 MRSEHNLLSRE---LHSVAPlldnltSALnKVYQRK--GVNITLDISPEITFVgeKND---FMEVMGNVLDNACKYCLEF 397
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502862580 798 AQIgvNASVEDHTLRLDVWDTGPGIPAGQEKAIFEkfsRGNKESAI-PGVGLGLAICQAIIDVHGGTISAENRPEGGARF 876
Cdd:PRK10815 398 VEI--SARQTDEHLHIVVEDDGPGIPESKRELIFD---RGQRADTLrPGQGLGLSVAREITEQYEGKISAGDSPLGGARM 472
|
...
gi 502862580 877 CVT 879
Cdd:PRK10815 473 EVI 475
|
|
| HATPase_HupT_MifS-like |
cd16976 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
780-880 |
7.24e-15 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Rhodobacter capsulatus HupT and Pseudomonas aeruginosa MifS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Rhodobacter capsulatus HupT of the HupT-HupR two-component regulatory system (TCS), which regulates the synthesis of HupSL, a membrane bound [NiFe]hydrogenase. It also contains the HATPase domain of Pseudomonas aeruginosa MifS, the HK of the MifS-MifR TCS, which may be involved in sensing alpha-ketoglutarate and regulating its transport and subsequent metabolism. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some also have a C-terminal PAS sensor domain.
Pssm-ID: 340435 [Multi-domain] Cd Length: 102 Bit Score: 70.95 E-value: 7.24e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502862580 780 ERVLINLLENAGKYAG--AHAQIGVNASVEDHTLRLDVWDTGPGIPAGQEKAIFEKFSRgNKESAiPGVGLGLAICQAII 857
Cdd:cd16976 2 QQVLMNLLQNALDAMGkvENPRIRIAARRLGGRLVLVVRDNGPGIAEEHLSRVFDPFFT-TKPVG-KGTGLGLSISYGIV 79
|
90 100
....*....|....*....|...
gi 502862580 858 DVHGGTISAENRPEGGARFCVTL 880
Cdd:cd16976 80 EEHGGRLSVANEEGAGARFTFDL 102
|
|
| HATPase_YcbM-like |
cd16947 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
761-880 |
7.40e-15 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Bacillus subtilis YcbM; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Bacillus subtilis YcbM, a HK of the two-component system YcbM-YcbL. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA).
Pssm-ID: 340423 [Multi-domain] Cd Length: 125 Bit Score: 71.78 E-value: 7.40e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502862580 761 IALNMPDPLTLIHVDGPLFERVLINLLENAGKYAGAHAQIGVNASVEDHTLRLDVWDTGPGIPAGQEKAIFEKF--SRGN 838
Cdd:cd16947 3 VEINIPDRPIYANANTEALQRILKNLISNAIKYGSDGKFLGMTLREDEKHVYIDIWDKGKGISETEKDHVFERLytLEDS 82
|
90 100 110 120
....*....|....*....|....*....|....*....|..
gi 502862580 839 KESAIPGVGLGLAICQAIIDVHGGTISAENRPEGGARFCVTL 880
Cdd:cd16947 83 RNSAKQGNGLGLTITKRLAESMGGSIYVNSKPYEKTVFTVTL 124
|
|
| PRK11091 |
PRK11091 |
aerobic respiration control sensor protein ArcB; Provisional |
669-894 |
5.18e-14 |
|
aerobic respiration control sensor protein ArcB; Provisional
Pssm-ID: 236842 [Multi-domain] Cd Length: 779 Bit Score: 76.13 E-value: 5.18e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502862580 669 AALSHDLRTPLTVLFGQSEILtLD--LAAEGSKHAlqaSEIrqHVLNTT--RLVNNLLDMARIQSGGFNLKKEWLTLEEV 744
Cdd:PRK11091 288 STISHELRTPLNGIVGLSRIL-LDteLTAEQRKYL---KTI--HVSAITlgNIFNDIIDMDKMERRKLQLDNQPIDFTDF 361
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502862580 745 VG-----SALkMLEP-GLggrhiALNMpDPLT----LIHVDGPLFERVLINLLENAGKYAgahAQIGVNASVEDH---TL 811
Cdd:PRK11091 362 LAdlenlSGL-QAEQkGL-----RFDL-EPLLplphKVITDGTRLRQILWNLISNAVKFT---QQGGVTVRVRYEegdML 431
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502862580 812 RLDVWDTGPGIPAGQEKAIFE-----KFSRGNKeSAIpGVGLGLAICQAIIDVHGGTISAENRPEGGARFCVTLPLDTPP 886
Cdd:PRK11091 432 TFEVEDSGIGIPEDELDKIFAmyyqvKDSHGGK-PAT-GTGIGLAVSKRLAQAMGGDITVTSEEGKGSCFTLTIHAPAVA 509
|
....*...
gi 502862580 887 ELDELPED 894
Cdd:PRK11091 510 EEVEDAFD 517
|
|
| PRK10841 |
PRK10841 |
two-component system sensor histidine kinase RcsC; |
642-882 |
6.11e-14 |
|
two-component system sensor histidine kinase RcsC;
Pssm-ID: 182772 [Multi-domain] Cd Length: 924 Bit Score: 76.17 E-value: 6.11e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502862580 642 LERLALTAseEQArlaSERESIrnsLLAALSHDLRTPLTVLFGQseiltLDLaaegskhaLQASEIRQHVlntTRLV--- 718
Cdd:PRK10841 433 LQEMAQAA--EQA---SQSKSM---FLATVSHELRTPLYGIIGN-----LDL--------LQTKELPKGV---DRLVtam 488
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502862580 719 NN-----------LLDMARIQSggfnlkkEWLTLE-------EVVGsalkmlepglggrHIALN-MP----DPLTL---I 772
Cdd:PRK10841 489 NNssslllkiisdILDFSKIES-------EQLKIEprefsprEVIN-------------HITANyLPlvvkKRLGLycfI 548
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502862580 773 HVDGPL--------FERVLINLLENAGKYA--GAhaqIGVNASVEDHTLRLDVWDTGPGIPAGQEKAIFEKFSR--GNKE 840
Cdd:PRK10841 549 EPDVPValngdpmrLQQVISNLLSNAIKFTdtGC---IVLHVRVDGDYLSFRVRDTGVGIPAKEVVRLFDPFFQvgTGVQ 625
|
250 260 270 280
....*....|....*....|....*....|....*....|..
gi 502862580 841 SAIPGVGLGLAICQAIIDVHGGTISAENRPEGGARFCVTLPL 882
Cdd:PRK10841 626 RNFQGTGLGLAICEKLINMMDGDISVDSEPGMGSQFTIRIPL 667
|
|
| phoR |
PRK11006 |
phosphate regulon sensor histidine kinase PhoR; |
661-881 |
1.42e-13 |
|
phosphate regulon sensor histidine kinase PhoR;
Pssm-ID: 182895 [Multi-domain] Cd Length: 430 Bit Score: 73.89 E-value: 1.42e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502862580 661 ESIRNSLLAALSHDLRTPLTVLFGQSEiLTLDLAAEGSkhalqaseIRQHVLNTTR--------LVNNLLDMARIQSGgf 732
Cdd:PRK11006 201 EGARRNFFANVSHELRTPLTVLQGYLE-MMQDQPLEGA--------LREKALHTMReqtqrmegLVKQLLTLSKIEAA-- 269
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502862580 733 nlkkEWLTLEEVVG--SALKMLE-----PGLGGRHIALNMPDPLTLIHVDGPLfeRVLI-NLLENAGKYAGAHAQIGVNA 804
Cdd:PRK11006 270 ----PTIDLNEKVDvpMMLRVLEreaqtLSQGKHTITFEVDNSLKVFGNEDQL--RSAIsNLVYNAVNHTPEGTHITVRW 343
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 502862580 805 SVEDHTLRLDVWDTGPGIPAGQEKAIFEKFSRGNK--ESAIPGVGLGLAICQAIIDVHGGTISAENRPEGGARFCVTLP 881
Cdd:PRK11006 344 QRVPQGAEFSVEDNGPGIAPEHIPRLTERFYRVDKarSRQTGGSGLGLAIVKHALSHHDSRLEIESEVGKGTRFSFVLP 422
|
|
| HATPase_BvrS-ChvG-like |
cd16953 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
781-881 |
1.73e-13 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Brucella abortus BvrS and Sinorhizobium meliloti ChvG; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Brucella abortus BvrS of the BvrR-BvrS two-component regulatory system (TCS), which controls cell invasion and intracellular survival, as well as Sinorhizobium meliloti and Agrobacterium tumefaciens ChvG of the ChvI-ChvG TCS necessary for endosymbiosis and pathogenicity in plants. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), an accessory HAMP sensor domain, a periplasmic stimulus-sensing domain, and some also have a sensor N-terminal transmembrane domain.
Pssm-ID: 340429 [Multi-domain] Cd Length: 110 Bit Score: 67.60 E-value: 1.73e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502862580 781 RVLINLLENAGKYA-GAHAQIGVNASVEDHTLRLDVWDTGPGIPAGQEKAIFEKFSRGNKESAIPGV--GLGLAICQAII 857
Cdd:cd16953 3 QVLRNLIGNAISFSpPDTGRITVSAMPTGKMVTISVEDEGPGIPQEKLESIFDRFYTERPANEAFGQhsGLGLSISRQII 82
|
90 100
....*....|....*....|....*...
gi 502862580 858 DVHGGTISAENRPEG----GARFCVTLP 881
Cdd:cd16953 83 EAHGGISVAENHNQPgqviGARFTVQLP 110
|
|
| HATPase_CreC-like |
cd16945 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
778-873 |
3.28e-13 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli CreC; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Escherichia coli CreC of the CreC-CreB two-component regulatory system (TCS) involved in catabolic regulation. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), and accessory sensory domain(s) such as HAMP, CACHE or PAS.
Pssm-ID: 340421 [Multi-domain] Cd Length: 106 Bit Score: 66.72 E-value: 3.28e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502862580 778 LFERVLINLLENAGKYAGAHAQIGVNASVEDHTLRLDVWDTGPGIPAGQEKAIFEKF-SRGNKESAIPGVGLGLAICQAI 856
Cdd:cd16945 4 LLRQAINNLLDNAIDFSPEGGLIALQLEADTEGIELLVFDEGSGIPDYALNRVFERFySLPRPHSGQKSTGLGLAFVQEV 83
|
90
....*....|....*..
gi 502862580 857 IDVHGGTISAENRPEGG 873
Cdd:cd16945 84 AQLHGGRITLRNRPDGV 100
|
|
| nifL_nitrog |
TIGR02938 |
nitrogen fixation negative regulator NifL; NifL is a modulator of the nitrogen fixation ... |
611-882 |
4.43e-13 |
|
nitrogen fixation negative regulator NifL; NifL is a modulator of the nitrogen fixation positive regulator protein NifA, and is therefore a negative regulator. It binds NifA. NifA and NifL are encoded by adjacent genes. [Central intermediary metabolism, Nitrogen fixation, Regulatory functions, Protein interactions]
Pssm-ID: 131984 [Multi-domain] Cd Length: 494 Bit Score: 72.63 E-value: 4.43e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502862580 611 LVIVEPSNLRQlmipEQQRLLetftllvASALErlALTASEEQArlaserESIRNSLLAALsHDLRTPLTVLfgQSEILT 690
Cdd:TIGR02938 243 LTIADISNLRE----EQERAR-------LSALQ--ALMAEEERL------EAIRETLSAAI-HRLQGPMNLI--SAAISV 300
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502862580 691 LDLAAEGSKHALQASEIRQHVLNTTRLVNNLLDMarIQSGGFNLKKEwLTLEEVVGSALKMLEPGLGGRHIALNMPDPLT 770
Cdd:TIGR02938 301 LQRRGDDAGNPASAAMLQQALSAGREHMEALRQV--IPQSPQEIVVP-VNLNQILRDVITLSTPRLLAAGIVVDWQPAAT 377
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502862580 771 LIHVDG-PLFERVLIN-LLENAGKyAGAHAQ-----IGVNASVEDHTLRLDVWDTGPGIPAGQEKAIFEKFSRgNKESAI 843
Cdd:TIGR02938 378 LPAILGrELQLRSLFKaLVDNAIE-AMNIKGwkrreLSITTALNGDLIVVSILDSGPGIPQDLRYKVFEPFFT-TKGGSR 455
|
250 260 270
....*....|....*....|....*....|....*....
gi 502862580 844 PGVGLGLAICQAIIDVHGGTISAENRPEGGARFCVTLPL 882
Cdd:TIGR02938 456 KHIGMGLSVAQEIVADHGGIIDLDDDYSEGCRIIVEFRV 494
|
|
| HATPase_DpiB-CitA-like |
cd16915 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
785-881 |
9.09e-13 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli K-12 DpiB, DcuS, and Bacillus subtilis CitS, DctS, and YufL; This family includes histidine kinase-like ATPase domains of Escherichia coli K-12 DpiB and DcuS, and Bacillus subtilis CitS, DctS and MalK histidine kinases (HKs) all of which are two component transduction systems (TCSs). E. coli K-12 DpiB (also known as CitA) is the histidine kinase (HK) of DpiA-DpiB, a two-component signal transduction system (TCS) required for the expression of citrate-specific fermentation genes and genes involved in plasmid inheritance. E. coli K-12 DcuS (also known as YjdH) is the HK of DcuS-DcuR, a TCS that in the presence of the extracellular C4-dicarboxlates, activates the expression of the genes of anaerobic fumarate respiration and of aerobic C4-dicarboxylate uptake. CitS is the HK of Bacillus subtilis CitS-CitT, a TCS which regulates expression of CitM, the Mg-citrate transporter. Bacillus subtilis DctS forms a tripartite sensor unit (DctS/DctA/DctB) for sensing C4 dicarboxylates. Bacillus subtilis MalK (also known as YfuL) is the HK of MalK-MalR (YufL-YufM) a TCS which regulates the expression of the malate transporters MaeN (YufR) and YflS, and is essential for utilization of malate in minimal medium. Proteins having this DpiB-CitA-like HATPase domain generally have sensor domains such as Cache and PAS, and a histidine kinase A (HisKA)-like SpoOB-type, alpha-helical domain.
Pssm-ID: 340392 [Multi-domain] Cd Length: 104 Bit Score: 65.00 E-value: 9.09e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502862580 785 NLLENA----GKYAGAHAQIGVNASVEDHTLRLDVWDTGPGIPAGQEKAIFEkfsRGNKESAIPGVGLGLAICQAIIDVH 860
Cdd:cd16915 7 NLIDNAldalAATGAPNKQVEVFLRDEGDDLVIEVRDTGPGIAPELRDKVFE---RGVSTKGQGERGIGLALVRQSVERL 83
|
90 100
....*....|....*....|.
gi 502862580 861 GGTISAENRPEGGARFCVTLP 881
Cdd:cd16915 84 GGSITVESEPGGGTTFSIRIP 104
|
|
| COG4192 |
COG4192 |
Signal transduction histidine kinase regulating phosphoglycerate transport system [Signal ... |
639-880 |
1.13e-12 |
|
Signal transduction histidine kinase regulating phosphoglycerate transport system [Signal transduction mechanisms];
Pssm-ID: 443346 [Multi-domain] Cd Length: 640 Bit Score: 71.64 E-value: 1.13e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502862580 639 ASALERLALTASEEQARLASERESIRNSLLAA------------LSHDLRTPLTVLfgQSEILTLDLAAEGSKHAlQASE 706
Cdd:COG4192 396 AIEKTQELETEIEERKRIEKNLRQTQDELIQAakmavvgqtmtsLAHELNQPLNAM--SMYLFSAKKALEQENYA-QLPT 472
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502862580 707 ----IRQHVLNTTRLVNNLLDMARIQSGGFNLkkewLTLEEVVGSALKMLEPGLGGRHIALNMPDPLtLIHVDGPLFERV 782
Cdd:COG4192 473 sldkIEGLIERMDKIIKSLRQFSRKSDTPLQP----VDLRQVIEQAWELVESRAKPQQITLHIPDDL-MVQGDQVLLEQV 547
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502862580 783 LINLLENAGKYAGAHAQIGVNASVEDHTLRLDVWDTGPGIPAGQEkaIFEKFSRgNKESaipGVGLGLAICQAIIDVHGG 862
Cdd:COG4192 548 LVNLLVNALDAVATQPQISVDLLSNAENLRVAISDNGNGWPLVDK--LFTPFTT-TKEV---GLGLGLSICRSIMQQFGG 621
|
250
....*....|....*...
gi 502862580 863 TISAENRPEGGArfCVTL 880
Cdd:COG4192 622 DLYLASTLERGA--MVIL 637
|
|
| PRK11107 |
PRK11107 |
hybrid sensory histidine kinase BarA; Provisional |
652-894 |
1.45e-12 |
|
hybrid sensory histidine kinase BarA; Provisional
Pssm-ID: 236848 [Multi-domain] Cd Length: 919 Bit Score: 71.80 E-value: 1.45e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502862580 652 EQARLASEresirnsLLAALSHDLRTPLTVLFG---QseilTLdlaaegsKHALQASEiRQHVLNTTRLVNNL------- 721
Cdd:PRK11107 288 EAARIKSE-------FLANMSHELRTPLNGVIGftrQ----TL-------KTPLTPTQ-RDYLQTIERSANNLlaiindi 348
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502862580 722 LDMARIQSGG-------FNLKKewlTLEEVV----GSAL-KMLEPGLggrHIALNMPDpltliHVDG-PL-FERVLINLL 787
Cdd:PRK11107 349 LDFSKLEAGKlvlenipFSLRE---TLDEVVtllaHSAHeKGLELTL---NIDPDVPD-----NVIGdPLrLQQIITNLV 417
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502862580 788 ENAGKYA--GAhaqigVNASVEDH-------TLRLDVWDTGPGIPAGQEKAIFEKFSRGnkESAIP----GVGLGLAICQ 854
Cdd:PRK11107 418 GNAIKFTesGN-----IDILVELRalsntkvQLEVQIRDTGIGISERQQSQLFQAFRQA--DASISrrhgGTGLGLVITQ 490
|
250 260 270 280
....*....|....*....|....*....|....*....|..
gi 502862580 855 AIIDVHGGTISAENRPEGGARFCVTLPLDTPPE--LDELPED 894
Cdd:PRK11107 491 KLVNEMGGDISFHSQPNRGSTFWFHLPLDLNPNpiIDGLPTD 532
|
|
| HATPase_Glnl-NtrB-like |
cd16918 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
780-881 |
2.33e-12 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli GlnL (synonyms NtrB and NRII); This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs), similar to Escherichia coli GlnL/NtrB/NRII HK of the two-component regulatory system (TCS) GlnL/GlnG (NtrB-NtrC, or NRII-NRI), which regulates the transcription of genes encoding metabolic enzymes and permeases in response to carbon and nitrogen status in E. coli and related bacteria. Also included in this family are Rhodobacter capsulatus NtrB, Azospirillum brasilense NtrB, Vibrio alginolyticus NtrB, Rhizobium leguminosarum biovar phaseoli NtrB, and Herbaspirillum seropedicae NtrB. Escherichia coli GlnL/NtrB/NRII is both a kinase and a phosphatase, catalyzing the phosphorylation and dephosphorylation of GlnG/NtrC/NRI. The kinase and phosphatase activities of GlnL/NtrB/NRII are regulated by the PII signal transduction protein, which on binding to GlnL/NtrB/NRII, inhibits the kinase activity of GlnL/NtrB/NRII and activates the GlnL/NtrB/NRII phosphatase activity. Proteins having this HATPase domain also have a histidine kinase dimerization and phosphoacceptor domain (HisKA); some also contain PAS sensor domain(s).
Pssm-ID: 340395 [Multi-domain] Cd Length: 109 Bit Score: 64.34 E-value: 2.33e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502862580 780 ERVLINLLENAGK-YAGAHAQIGVNASVEDH----------TLRLDVWDTGPGIPAGQEKAIFEKFSRGNKEsaipGVGL 848
Cdd:cd16918 2 IQVFLNLVRNAAQaLAGSGGEIILRTRTQRQvtlghprhrlALRVSVIDNGPGIPPDLQDTIFYPMVSGREN----GTGL 77
|
90 100 110
....*....|....*....|....*....|...
gi 502862580 849 GLAICQAIIDVHGGTISAENRPeGGARFCVTLP 881
Cdd:cd16918 78 GLAIAQNIVSQHGGVIECDSQP-GHTVFSVSLP 109
|
|
| PRK13837 |
PRK13837 |
two-component system VirA-like sensor kinase; |
643-887 |
1.18e-11 |
|
two-component system VirA-like sensor kinase;
Pssm-ID: 237526 [Multi-domain] Cd Length: 828 Bit Score: 68.55 E-value: 1.18e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502862580 643 ERLALTASEEQARlaseRESIRNSLLAALSHDLRTPLTVLFGQSEIlTLDLAAEGSKHALQASEIRQHVLNTTRLVNNLL 722
Cdd:PRK13837 433 ERDALERRLEHAR----RLEAVGTLASGIAHNFNNILGAILGYAEM-ALNKLARHSRAARYIDEIISAGARARLIIDQIL 507
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502862580 723 DMARIQsggfNLKKEWLTLEEVVGSALKMLEPGLGgRHIALNMPDPLTLIHVDG-PL-FERVLINLLENAGKYAGAHAQI 800
Cdd:PRK13837 508 AFGRKG----ERNTKPFDLSELVTEIAPLLRVSLP-PGVELDFDQDQEPAVVEGnPAeLQQVLMNLCSNAAQAMDGAGRV 582
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502862580 801 GVNASVEDHT---------------LRLDVWDTGPGIPAGQEKAIFEKF----SRGNkesaipgvGLGLAICQAIIDVHG 861
Cdd:PRK13837 583 DISLSRAKLRapkvlshgvlppgryVLLRVSDTGAGIDEAVLPHIFEPFfttrAGGT--------GLGLATVHGIVSAHA 654
|
250 260
....*....|....*....|....*.
gi 502862580 862 GTISAENRPEGGARFCVTLPLDTPPE 887
Cdd:PRK13837 655 GYIDVQSTVGRGTRFDVYLPPSSKVP 680
|
|
| HisKA |
pfam00512 |
His Kinase A (phospho-acceptor) domain; dimerization and phospho-acceptor domain of histidine ... |
664-730 |
2.83e-11 |
|
His Kinase A (phospho-acceptor) domain; dimerization and phospho-acceptor domain of histidine kinases.
Pssm-ID: 459839 [Multi-domain] Cd Length: 66 Bit Score: 59.53 E-value: 2.83e-11
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 502862580 664 RNSLLAALSHDLRTPLTVLFGQSEILTLDLAAEGSKHALQAseIRQHVLNTTRLVNNLLDMARIQSG 730
Cdd:pfam00512 2 KSEFLANLSHELRTPLTAIRGYLELLRDEKLDEEQREYLET--ILRSAERLLRLINDLLDLSRIEAG 66
|
|
| HATPase_NtrY-like |
cd16944 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
775-881 |
3.17e-11 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Azorhizobium caulinodans NtrY; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs) such as Azorhizobium caulinodans ORS571 NtrY of the NtrY-NtrX TCS, which is involved in nitrogen fixation and metabolism. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and a HAMP sensor domain; some also have PAS sensor domains.
Pssm-ID: 340420 [Multi-domain] Cd Length: 108 Bit Score: 61.01 E-value: 3.17e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502862580 775 DGPLFERVLINLLENAGKYAGA------HAQIGVNASvEDHTLRLDVWDTGPGIPAGQEKAIFEKFSRGNKEsaipGVGL 848
Cdd:cd16944 1 DTTQISQVLTNILKNAAEAIEGrpsdvgEVRIRVEAD-QDGRIVLIVCDNGKGFPREMRHRATEPYVTTRPK----GTGL 75
|
90 100 110
....*....|....*....|....*....|...
gi 502862580 849 GLAICQAIIDVHGGTISAENRPEGGARFCVTLP 881
Cdd:cd16944 76 GLAIVKKIMEEHGGRISLSNREAGGACIRIILP 108
|
|
| HATPase_EcPhoR-like |
cd16952 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
785-881 |
1.81e-10 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli PhoR; This family includes histidine kinase-like ATPase (HATPase) domain of two-component sensor histidine kinases similar to Escherichia coli or Vibrio cholera PhoR, the histidine kinase (HK) of PhoB-PhoR a two-component signal transduction system (TCS) involved in phosphate regulation. PhoR monitors extracellular inorganic phosphate (Pi) availability and PhoB, the response regulator, regulates transcription of genes of the phosphate regulon. PhoR is a bifunctional histidine autokinase/phospho-PhoB phosphatase; in phosphate deficiency, it autophosphorylates and Pi is transferred to PhoB, and when environmental Pi is abundant, it removes the phosphoryl group from phosphorylated PhoB. Other roles of PhoB-PhoR TCS have been described, including motility, biofilm formation, intestinal colonization, and virulence in V. cholera. E.coli PhoR and Bacillus subtilis PhoR (whose HATPase domain belongs to a different family) sense very different signals in each bacterium. In E. coli the PhoR signal comes from phosphate transport mediated by the PstSCAB2 phosphate transporter and the PhoU chaperone-like protein while in B. subtilis, the PhoR activation signal comes from wall teichoic acid (WTA) metabolism.
Pssm-ID: 340428 [Multi-domain] Cd Length: 108 Bit Score: 58.75 E-value: 1.81e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502862580 785 NLLENAGKYAGAHAQIGVNASVEDHTLRLDVWDTGPGIPAGQEKAIFEKFSRGNKESA--IPGVGLGLAICQAIIDVHGG 862
Cdd:cd16952 7 NLVSNAVKYTPPSDTITVRWSQEESGARLSVEDTGPGIPPEHIPRLTERFYRVDIERCrnTGGTGLGLAIVKHVMSRHDA 86
|
90
....*....|....*....
gi 502862580 863 TISAENRPEGGARFCVTLP 881
Cdd:cd16952 87 RLLIASELGKGSRFTCLFP 105
|
|
| HATPase_SpaK_NisK-like |
cd16975 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
775-880 |
3.29e-10 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Bacillus subtilis SpaK and Lactococcus lactis NisK; This family includes histidine kinase-like ATPase (HATPase) domain of two-component sensor histidine kinases similar to Bacillus subtilis SpaK and Lactococcus lactis NisK. SpaK is the histidine kinase (HK) of the SpaK-SpaR two-component regulatory system (TCS), which is involved in the regulation of the biosynthesis of lantibiotic subtilin. NisK is the HK of the NisK-NisR TCS, which is involved in the regulation of the biosynthesis of lantibiotic nisin. SpaK and NisK may function as membrane-associated protein kinases that phosphorylate SpaR and NisR, respectively, in response to environmental signals.
Pssm-ID: 340434 [Multi-domain] Cd Length: 107 Bit Score: 57.86 E-value: 3.29e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502862580 775 DGPLFERVLINLLENAGKYAGAHAQIGVNASVEDHTLRLDVWDTGPGIPAGQEKAIFEKFSRGNKESAIPG-VGLGLAIC 853
Cdd:cd16975 1 DTLLLSRALINIISNACQYAPEGGTVSISIYDEEEYLYFEIWDNGHGFSEQDLKKALELFYRDDTSRRSGGhYGMGLYIA 80
|
90 100
....*....|....*....|....*..
gi 502862580 854 QAIIDVHGGTISAENRPEGGArfCVTL 880
Cdd:cd16975 81 KNLVEKHGGSLIIENSQKGGA--EVTV 105
|
|
| HisKA |
smart00388 |
His Kinase A (phosphoacceptor) domain; Dimerisation and phosphoacceptor domain of histidine ... |
664-730 |
4.83e-10 |
|
His Kinase A (phosphoacceptor) domain; Dimerisation and phosphoacceptor domain of histidine kinases.
Pssm-ID: 214644 [Multi-domain] Cd Length: 66 Bit Score: 56.04 E-value: 4.83e-10
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 502862580 664 RNSLLAALSHDLRTPLTVLFGQSEILTLDLAAEGSKHALQAseIRQHVLNTTRLVNNLLDMARIQSG 730
Cdd:smart00388 2 KREFLANLSHELRTPLTAIRGYLELLLDTELSEEQREYLET--ILREAERLLRLINDLLDLSRIEAG 66
|
|
| HisKA |
cd00082 |
Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed ... |
661-726 |
2.72e-08 |
|
Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-autophosphorylation by the catalytic domain of the histidine kinase. They subsequently transfer the phosphoryl group to the Asp acceptor residue of a response regulator protein. Two-component signalling systems, consisting of a histidine protein kinase that senses a signal input and a response regulator that mediates the output, are ancient and evolutionarily conserved signaling mechanisms in prokaryotes and eukaryotes.
Pssm-ID: 119399 [Multi-domain] Cd Length: 65 Bit Score: 51.06 E-value: 2.72e-08
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 502862580 661 ESIRNSLLAALSHDLRTPLTVLFGQSEILtLDLAAEGSKHALQASEIRQHVLNTTRLVNNLLDMAR 726
Cdd:cd00082 1 LQAKGEFLANVSHELRTPLTAIRGALELL-EEELLDDEEQREYLERIREEAERLLRLINDLLDLSR 65
|
|
| PRK11086 |
PRK11086 |
sensory histidine kinase DcuS; Provisional |
782-883 |
6.35e-08 |
|
sensory histidine kinase DcuS; Provisional
Pssm-ID: 236839 [Multi-domain] Cd Length: 542 Bit Score: 56.07 E-value: 6.35e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502862580 782 VLINLLENAGKYAGAHA--QIGVNASVEDHTLRLDVWDTGPGIPAGQEKAIFEK-FS-RGNkesaipGVGLGLAICQAII 857
Cdd:PRK11086 437 ILGNLIENALEAVGGEEggEISVSLHYRNGWLHCEVSDDGPGIAPDEIDAIFDKgYStKGS------NRGVGLYLVKQSV 510
|
90 100
....*....|....*....|....*.
gi 502862580 858 DVHGGTISAENRPEGGARFCVTLPLD 883
Cdd:PRK11086 511 ENLGGSIAVESEPGVGTQFFVQIPWD 536
|
|
| GAF_3 |
pfam13492 |
GAF domain; |
530-644 |
1.30e-07 |
|
GAF domain;
Pssm-ID: 433253 [Multi-domain] Cd Length: 129 Bit Score: 51.22 E-value: 1.30e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502862580 530 DIVQTSEQFIRSTFNASNLILLPDE------------HGKLRPLTS-ATGMTPWDEAIARWSFDKGlPAGAGTDTLPGVP 596
Cdd:pfam13492 4 EILEALLKLLVRLLGAERAAVYLLDedgnklqvaagyDGEPDPSESlDADSPLARRALSSGEPISG-LGSAGEDGLPDGP 82
|
90 100 110 120
....*....|....*....|....*....|....*....|....*...
gi 502862580 597 YQILPLRSADKNQGLVIVEPSNLRQLmIPEQQRLLETFTLLVASALER 644
Cdd:pfam13492 83 ALVVPLVAGRRVIGVLALASSKPRAF-DAEDLRLLESLAAQIATAIEN 129
|
|
| Usp |
pfam00582 |
Universal stress protein family; The universal stress protein UspA is a small cytoplasmic ... |
253-372 |
1.37e-07 |
|
Universal stress protein family; The universal stress protein UspA is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. UspA enhances the rate of cell survival during prolonged exposure to such conditions, and may provide a general "stress endurance" activity. The crystal structure of Haemophilus influenzae UspA reveals an alpha/beta fold similar to that of the Methanococcus jannaschii MJ0577 protein, which binds ATP, though UspA lacks ATP-binding activity.
Pssm-ID: 425765 [Multi-domain] Cd Length: 137 Bit Score: 51.25 E-value: 1.37e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502862580 253 ILLCIGHGSGNEKLVRTAARLAAKFGSVWHAVYV---------------ETPQLHALPENQRRAILSSLRLAQELGAETA 317
Cdd:pfam00582 1 ILVAVDGSEESKRALEWAAELAKARGAELILLHVidpppsgaasladesAEEEELELELAEAEALAAAAAAEAGGVKVEV 80
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*...
gi 502862580 318 TLSDPQEDKAILRYAREHNLGKIVIGRRqHRRWFSRE---SFADKLARRAPdLDLVVV 372
Cdd:pfam00582 81 VVVVGDPAEEILEVAEEEDADLIVMGSR-GRSGLSRLllgSVAEYVLRHAP-CPVLVV 136
|
|
| glnL |
PRK11073 |
nitrogen regulation protein NR(II); |
761-882 |
1.61e-07 |
|
nitrogen regulation protein NR(II);
Pssm-ID: 182947 [Multi-domain] Cd Length: 348 Bit Score: 54.32 E-value: 1.61e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502862580 761 IALNMPDPLTLIH----------VDGPLFERVLINLLENAGKYAG-AHAQI--------GVNASVEDHTL--RLDVWDTG 819
Cdd:PRK11073 210 VSLELPDNVRLIRdydpslpelaHDPDQIEQVLLNIVRNALQALGpEGGTItlrtrtafQLTLHGERYRLaaRIDIEDNG 289
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 502862580 820 PGIPAGQEKAIFEKFSRGnKESaipGVGLGLAICQAIIDVHGGTISAENRPeGGARFCVTLPL 882
Cdd:PRK11073 290 PGIPPHLQDTLFYPMVSG-REG---GTGLGLSIARNLIDQHSGKIEFTSWP-GHTEFSVYLPI 347
|
|
| ComP |
COG4585 |
Signal transduction histidine kinase ComP [Signal transduction mechanisms]; |
622-885 |
6.38e-07 |
|
Signal transduction histidine kinase ComP [Signal transduction mechanisms];
Pssm-ID: 443642 [Multi-domain] Cd Length: 252 Bit Score: 51.54 E-value: 6.38e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502862580 622 LMIPEQQRLLETFTLLVASALERLALTASEEQARLASEresIRNSL---LAALSHDLRTPLTVLFGQSEIL--TLDLAAE 696
Cdd:COG4585 23 ALVLLRARRAERAAELERELAARAEEAREEERRRIARE---LHDGVgqsLSAIKLQLEAARRLLDADPEAAreELEEIRE 99
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502862580 697 GSKHALQasEIRqhvlnttRLVNNLLDMARiqsggfnlkkEWLTLEEVVGSALKMLEpGLGGRHIALNMPDPLTLI--HV 774
Cdd:COG4585 100 LAREALA--ELR-------RLVRGLRPPAL----------DDLGLAAALEELAERLL-RAAGIRVELDVDGDPDRLppEV 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502862580 775 DGPLFeRVLINLLENAGKYAGAhAQIGVNASVEDHTLRLDVWDTGPGIPAGqekaifekfsrgnkesAIPGVGLGLAICQ 854
Cdd:COG4585 160 ELALY-RIVQEALTNALKHAGA-TRVTVTLEVDDGELTLTVRDDGVGFDPE----------------AAPGGGLGLRGMR 221
|
250 260 270
....*....|....*....|....*....|.
gi 502862580 855 AIIDVHGGTISAENRPEGGARFCVTLPLDTP 885
Cdd:COG4585 222 ERAEALGGTLTIGSAPGGGTRVRATLPLAAA 252
|
|
| COG3920 |
COG3920 |
Two-component sensor histidine kinase, HisKA and HATPase domains [Signal transduction ... |
411-883 |
4.54e-06 |
|
Two-component sensor histidine kinase, HisKA and HATPase domains [Signal transduction mechanisms];
Pssm-ID: 443125 [Multi-domain] Cd Length: 495 Bit Score: 50.29 E-value: 4.54e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502862580 411 LITFIASQWLIAFDAANLVMIYLLGVVVVALFYGRWPSVLATVINVISFDLFFIDPRGTLAVSDVQYVLTFAVMLTVGLV 490
Cdd:COG3920 42 LLLALLLASALLALLALSAAALAAALAVALAAAVGAAAALLALLVLLLLLLLAAAALALALLLAALAGLLLLAALLLLRL 121
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502862580 491 IGNLTAGVRYQARIARYREQRTRHLYEMSKSLAVGRTPLDIVQTSEQFIRSTFNASNLILLPDEHGKLRPLTSATGMTPW 570
Cdd:COG3920 122 VALLAALALLALLLLLLLLLAILALAELAVALAELAAALLLLAEELAALRLAAAALLLLLAALLDLGLALAALAAAALLA 201
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502862580 571 DEAIARWSFDKGLPAGAGTDTLPGVPYQILPLRSADKNQGLVIVEPSNLRQLMIPEQQRLLETFTLLVASALERLALTAS 650
Cdd:COG3920 202 LLLALELLLALLLLLLLLLALLLVLLAALLRLRAAVLEELERRRRARGLGRLLLLLLLLLLLLRALLLLAAGIRLVITER 281
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502862580 651 EEQARLASERESIRNSLLAALSHDLRTPLTVLfgQSeILTLDLAAEGSKHALQASEirqhvlnttRLVNNLLDMARIQ-- 728
Cdd:COG3920 282 KRAEEELEASLEEKELLLRELHHRVKNNLQVV--SS-LLRLQARRADDPEAREALE---------ESQNRIQALALVHel 349
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502862580 729 -SGGFNLKKewLTLEEVVGSALKMLEPGLGGRHIALNM--------PD---PLTLIhvdgplfervlIN-LLENAGKYA- 794
Cdd:COG3920 350 lYQSEDWEG--VDLRDYLRELLEPLRDSYGGRGIRIELdgpdvelpADaavPLGLI-----------LNeLVTNALKHAf 416
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502862580 795 --GAHAQIGVNASVEDHTLRLDVWDTGPGIPAGqekaifekFSRGNKEsaipgvGLGLAICQAIIDVHGGTISAENRPeg 872
Cdd:COG3920 417 lsGEGGRIRVSWRREDGRLRLTVSDNGVGLPED--------VDPPARK------GLGLRLIRALVRQLGGTLELDRPE-- 480
|
490
....*....|.
gi 502862580 873 GARFCVTLPLD 883
Cdd:COG3920 481 GTRVRITFPLA 491
|
|
| YesM |
COG2972 |
Sensor histidine kinase YesM [Signal transduction mechanisms]; |
786-882 |
5.59e-06 |
|
Sensor histidine kinase YesM [Signal transduction mechanisms];
Pssm-ID: 442211 [Multi-domain] Cd Length: 445 Bit Score: 50.02 E-value: 5.59e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502862580 786 LLENAGKYA----GAHAQIGVNASVEDHTLRLDVWDTGPGIPAGQEKAIFEKFSRGNKESaipgvGLGLAICQAIIDVH- 860
Cdd:COG2972 344 LVENAIEHGiepkEGGGTIRISIRKEGDRLVITVEDNGVGMPEEKLEKLLEELSSKGEGR-----GIGLRNVRERLKLYy 418
|
90 100
....*....|....*....|....
gi 502862580 861 --GGTISAENRPEGGARFCVTLPL 882
Cdd:COG2972 419 geEYGLEIESEPGEGTTVTIRIPL 442
|
|
| UspA |
COG0589 |
Nucleotide-binding universal stress protein, UspA family [Signal transduction mechanisms]; |
253-365 |
7.20e-06 |
|
Nucleotide-binding universal stress protein, UspA family [Signal transduction mechanisms];
Pssm-ID: 440354 Cd Length: 136 Bit Score: 46.45 E-value: 7.20e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502862580 253 ILLCIGHGSGNEKLVRTAARLAAKFGSVWHAVYVETPQLHALP---------ENQRRAILSSLR-LAQELGAETATL--- 319
Cdd:COG0589 5 ILVPTDGSEEAERALEYAAELAKALGAELHLLHVVDPPPSAAAgpeeleeelREEAEEALEEAAeRLEEAGVEVETVvre 84
|
90 100 110 120
....*....|....*....|....*....|....*....|....*....
gi 502862580 320 SDPQEdkAILRYAREHNLGKIVIGRRQHRRwFSRE---SFADKLARRAP 365
Cdd:COG0589 85 GDPAE--AILEAAEELDADLIVMGSRGRSG-LRRLllgSVAERVLRHAP 130
|
|
| HATPase_BceS-YxdK-YvcQ-like |
cd16948 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
786-881 |
1.05e-05 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Bacillus subtilis BceS, YxdK, and Bacillus thuringiensis YvcQ; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Bacillus subtilis BceS and Bacillus thuringiensis YvcQ, the HKs of the two-component regulatory system (TCSs) BceS-BceR and YvcQ-YvcP, repsectively, which are both involved in regulating bacitracin resistance. It also includes the HATPase domain of YxdK, the HK of YxdK-YxdJ TCS involved in sensing antimicrobial compounds.
Pssm-ID: 340424 [Multi-domain] Cd Length: 109 Bit Score: 45.35 E-value: 1.05e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502862580 786 LLENAGKYAGAHAQIGVNASVEDHTLRLDVWDTGPGIPAGQEKAIFEKF---SRGNKESAIPGVGLGLAicQAIIDVHGG 862
Cdd:cd16948 13 IVSNALKYSKQGGKIEIYSETNEQGVVLSIKDFGIGIPEEDLPRVFDKGftgENGRNFQESTGMGLYLV--KKLCDKLGH 90
|
90
....*....|....*....
gi 502862580 863 TISAENRPEGGARFCVTLP 881
Cdd:cd16948 91 KIDVESEVGEGTTFTITFP 109
|
|
| USP-like |
cd00293 |
universal stress protein (USP) and similar proteins; The universal stress protein (USP) is a ... |
253-365 |
1.95e-05 |
|
universal stress protein (USP) and similar proteins; The universal stress protein (USP) is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. USP enhances the rate of cell survival during prolonged exposure to such conditions, and may provide a general "stress endurance" activity. The crystal structure of Haemophilus influenzae Usp reveals an alpha/beta fold similar to that of the Methanococcus jannaschii MJ0577 protein, which binds ATP, although USP lacks ATP-binding activity.
Pssm-ID: 467483 [Multi-domain] Cd Length: 135 Bit Score: 45.03 E-value: 1.95e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502862580 253 ILLCIGHGSGNEKLVRTAARLAAKFGSVWHAVYV-----------ETPQLHALPENQRRAILSSLR-LAQELGAETATL- 319
Cdd:cd00293 2 ILVAVDGSEESERALEWALELAKRPGAELTLLHVvdpppssslsgGLEELADELKEEAEELLEEAKkLAEEAGVEVETIv 81
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|
gi 502862580 320 --SDPqeDKAILRYAREHNLGKIVIGRRQHRRW--FSRESFADKLARRAP 365
Cdd:cd00293 82 veGDP--AEAILEEAKELGADLIVMGSRGRSGLkrLLLGSVSEYVLRHAP 129
|
|
| HATPase_CckA-like |
cd16919 |
Histidine kinase-like ATPase domain of two-component sensor hybrid histidine kinases, similar ... |
779-881 |
7.04e-04 |
|
Histidine kinase-like ATPase domain of two-component sensor hybrid histidine kinases, similar to Brucella abortus 2308 CckA; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component hybrid sensor histidine kinase (HKs) similar to Brucella abortus 2308 CckA, which is a component of an essential protein phosphorelay that regulates expression of genes required for growth, division, and intracellular survival; phosphoryl transfer initiates from the sensor kinase CckA and proceeds via the ChpT phosphotransferase to two regulatory substrates: the DNA-binding response regulator CtrA and the phospho-receiver protein CpdR. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), a REC signal receiver domain, and some contain PAS or PAS and GAF sensor domain(s).
Pssm-ID: 340396 [Multi-domain] Cd Length: 116 Bit Score: 40.06 E-value: 7.04e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502862580 779 FERVLINLLENA-------GKYAGAHAQIGVNASVEDHTLRL--------DVWDTGPGIPAGQEKAIFEKFSRGNKESAi 843
Cdd:cd16919 1 LELAILNLAVNArdampegGRLTIETSNQRVDADYALNYRDLipgnyvclEVSDTGSGMPAEVLRRAFEPFFTTKEVGK- 79
|
90 100 110
....*....|....*....|....*....|....*...
gi 502862580 844 pGVGLGLAICQAIIDVHGGTISAENRPEGGARFCVTLP 881
Cdd:cd16919 80 -GTGLGLSMVYGFVKQSGGHLRIYSEPGVGTTVRIYLP 116
|
|
| HATPase_UhpB-NarQ-NarX-like |
cd16917 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
781-881 |
9.62e-04 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli UhpB, NarQ and NarX, and Bacillus subtilis YdfH, YhcY and YfiJ; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs) such as Escherichia coli UhpB, a HK of the UhpB-UhpA TCS, NarQ and NarX, HKs of the NarQ-NarP and NarX-NarL TCSs, respectively, and Bacillus YdfH, YhcY and YfiJ HKs, of the YdfH-YdfI, YhcY-YhcZ and YfiJ-YfiK TCSs, respectively. In addition, it includes Bacillus YxjM, ComP, LiaS and DesK, HKs of the YxjM-YxjML, ComP-ComA, LiaS-LiaR, DesR-DesK TCSs, respectively. Proteins having this HATPase domain have a histidine kinase dimerization and phosphoacceptor domain; some have accessory domains such as GAF, HAMP, PAS and MASE sensor domains.
Pssm-ID: 340394 [Multi-domain] Cd Length: 87 Bit Score: 39.07 E-value: 9.62e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502862580 781 RVLINLLENAGKYAGAhAQIGVNASVEDHTLRLDVWDTGPGIPAGQEKaifekfsrgnkesaiPGVGLGLAICQAIIDVH 860
Cdd:cd16917 3 RIVQEALTNALKHAGA-SRVRVTLSYTADELTLTVVDDGVGFDGPAPP---------------GGGGFGLLGMRERAELL 66
|
90 100
....*....|....*....|.
gi 502862580 861 GGTISAENRPEGGARFCVTLP 881
Cdd:cd16917 67 GGTLTIGSRPGGGTRVTARLP 87
|
|
| dpiB |
PRK15053 |
sensor histidine kinase DpiB; Provisional |
704-881 |
6.87e-03 |
|
sensor histidine kinase DpiB; Provisional
Pssm-ID: 185013 [Multi-domain] Cd Length: 545 Bit Score: 40.20 E-value: 6.87e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502862580 704 ASEIRQHVLNTTRLVNNLLDMARIQSGGFNLKKEW-LTLEEVVGSALKMLEPGLggrhialnmpdpltlihvDGPLFERV 782
Cdd:PRK15053 375 ESQAQQQLIDSLREAFADRQVAGLLFGKVQRARELgLKMVIVPGSQLSQLPPGL------------------DSTEFAAI 436
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502862580 783 LINLLENAG----KYAGAHAQIGVNASVEDHTLRLDVWDTGPGIPAGQEKAIFEK-FSRGNKEsaiPGV-GLGLAICQAI 856
Cdd:PRK15053 437 VGNLLDNAFeaslRSDEGNKIVELFLSDEGDDVVIEVADQGCGVPESLRDKIFEQgVSTRADE---PGEhGIGLYLIASY 513
|
170 180
....*....|....*....|....*
gi 502862580 857 IDVHGGTISAENRPEGGARFCVTLP 881
Cdd:PRK15053 514 VTRCGGVITLEDNDPCGTLFSIFIP 538
|
|
| |
