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Conserved domains on  [gi|502862603|ref|WP_013097579|]
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MULTISPECIES: amino acid ABC transporter permease [Enterobacter]

Protein Classification

amino acid ABC transporter permease( domain architecture ID 11433582)

amino acid ABC transporter permease is the transmembrane (TM) subunit of a periplasmic binding protein (PBP)-dependent ATP-binding cassette (ABC) transporter which binds and transports amino acids

Gene Ontology:  GO:0140359|GO:0042626|GO:0006865
PubMed:  25750732|24638992
TCDB:  3.A.1

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
HisM COG0765
ABC-type amino acid transport system, permease component [Amino acid transport and metabolism]; ...
 4-240 9.39e-66

ABC-type amino acid transport system, permease component [Amino acid transport and metabolism];


:

Pssm-ID: 440528 [Multi-domain]  Cd Length: 218  Bit Score: 203.00  E-value: 9.39e-66
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502862603   4 DWNWGIFLQqapfgnttYLGWLWSGFQVTVALSITAWIIAFLVGSLFGILRTVPNRFLSSIGTLYVELFRNVPLIVQFFT 83
Cdd:COG0765    2 FFDFSVLLD--------YLPLLLEGLLVTLLLTVLAIVLGLVLGLLLALARLSPNPVLRWLATAYVEFFRGTPLLVQLFF 73

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502862603  84 WYLVVPELlpeniGMwfksELDPnvqfFVSSMMCLGLFTAARVCEQVRAAIQSLPRGQKNAGLAMGLTLPQTYRYVLLPN 163
Cdd:COG0765   74 IYFGLPLL-----GI----DLSP----FVAAVIALTLNSAAYLAEIVRAGIQSVPKGQWEAARALGLSRWQTMRRIILPQ 140

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 502862603 164 AYRVIVPPMTSEMMNLVKNSAIASTIGLVDMAAQAGKLLDYSAHAWESFTAITLAYVLINAFIMLVMNLVERKIRLP 240
Cdd:COG0765  141 ALRIILPPLGNEFISLLKDTSLVSVIGVPELTRAAQQIASRTFRPFEVYLVAALIYLVLTLPLSLLARRLERRLARG 217
 
Name Accession Description Interval E-value
HisM COG0765
ABC-type amino acid transport system, permease component [Amino acid transport and metabolism]; ...
 4-240 9.39e-66

ABC-type amino acid transport system, permease component [Amino acid transport and metabolism];


Pssm-ID: 440528 [Multi-domain]  Cd Length: 218  Bit Score: 203.00  E-value: 9.39e-66
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502862603   4 DWNWGIFLQqapfgnttYLGWLWSGFQVTVALSITAWIIAFLVGSLFGILRTVPNRFLSSIGTLYVELFRNVPLIVQFFT 83
Cdd:COG0765    2 FFDFSVLLD--------YLPLLLEGLLVTLLLTVLAIVLGLVLGLLLALARLSPNPVLRWLATAYVEFFRGTPLLVQLFF 73

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502862603  84 WYLVVPELlpeniGMwfksELDPnvqfFVSSMMCLGLFTAARVCEQVRAAIQSLPRGQKNAGLAMGLTLPQTYRYVLLPN 163
Cdd:COG0765   74 IYFGLPLL-----GI----DLSP----FVAAVIALTLNSAAYLAEIVRAGIQSVPKGQWEAARALGLSRWQTMRRIILPQ 140

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 502862603 164 AYRVIVPPMTSEMMNLVKNSAIASTIGLVDMAAQAGKLLDYSAHAWESFTAITLAYVLINAFIMLVMNLVERKIRLP 240
Cdd:COG0765  141 ALRIILPPLGNEFISLLKDTSLVSVIGVPELTRAAQQIASRTFRPFEVYLVAALIYLVLTLPLSLLARRLERRLARG 217
PRK15107 PRK15107
glutamate/aspartate ABC transporter permease GltK;
22-193 1.56e-26

glutamate/aspartate ABC transporter permease GltK;


Pssm-ID: 185062 [Multi-domain]  Cd Length: 224  Bit Score: 102.60  E-value: 1.56e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502862603  22 LGWLWSGFQVTVALSITAWIIAFLVGSLFGILRTVPNRFLSSIGTLYVELFRNVPLIVQFFTWYLVVPELLPENIGMWFK 101
Cdd:PRK15107  13 LPYLLDGLVITLKITVTAVVIGILWGTILAVMRLSSFKPVAWFAKAYVNVFRSIPLVMVLLWFYLIVPGFLQNVLGLSPK 92

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502862603 102 SELDpnvqfFVSSMMCLGLFTAARVCEQVRAAIQSLPRGQKNAGLAMGLTLPQTYRYVLLPNAYRVIVPPMTSEMMNLVK 181
Cdd:PRK15107  93 TDIR-----LISAMVAFSMFEAAYYSEIIRAGIQSISRGQSSAALALGMTHWQSMKLIILPQAFRAMVPLLLTQGIVLFQ 167

                        170
                 ....*....|..
gi 502862603 182 NSAIASTIGLVD 193
Cdd:PRK15107 168 DTSLVYVLSLAD 179
ectoine_ehuD TIGR03003
ectoine/hydroxyectoine ABC transporter, permease protein EhuD; Members of this family are ...
 25-237 5.46e-19

ectoine/hydroxyectoine ABC transporter, permease protein EhuD; Members of this family are presumed to act as permease subunits of ectoine ABC transporters. Operons containing this gene also contain the other genes of the ABC transporter and typically are found next to either ectoine utilization or ectoine biosynthesis operons.


Pssm-ID: 132048 [Multi-domain]  Cd Length: 212  Bit Score: 82.21  E-value: 5.46e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502862603   25 LWSGFQVTVALSITAWIIAFLVGSLFGILRTVPNRFLSSIGTLYVELFRNVPLIVQFFTWYLVVPellpeNIGMWFKSel 104
Cdd:TIGR03003  13 LIEGLKITILATALGFAIAAVLGLVFAILRRSAPTPISWPTSFVVEFIRGTPLLVQLYFLYYVLP-----DIGIRLPA-- 85

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502862603  105 dpnvqfFVSSMMCLGLFTAARVCEQVRAAIQSLPRGQKNAGLAMGLTLPQTYRYVLLPNAYRVIVPPMTSEMMNLVKNSA 184
Cdd:TIGR03003  86 ------LVAGVLGLGLHYATYAAEVYRAGIEAVPRGQWEAATALNLTARQTYRHIILPQAIPPIIPALGNYLVAMFKETP 159

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|...
gi 502862603  185 IASTIGLVDMAAQAGKLLDYSAHAWESFTAITLAYVLINAFIMLVMNLVERKI 237
Cdd:TIGR03003 160 VLSAITVLELMNQAKSIGNSTFRYLEPMTLVGVFFLILSIISVFFLRRLEARL 212
TM_PBP2 cd06261
Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding ...
 29-228 2.30e-17

Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and are mainly involved in importing solutes from the environment. The solute is captured by the PBP which delivers it to a gated translocation pathway formed by the two TMs. The two ABCs bind and hydrolyze ATP and drive the transport reaction. For these transporters the ABCs and TMs are on independent polypeptide chains. These systems transport a diverse range of substrates. Most are specific for a single substrate or a group of related substrates; however some transporters are more promiscuous, transporting structurally diverse substrates such as the histidine/lysine and arginine transporter in Enterobacteriaceae. In the latter case, this is achieved through binding different PBPs with different specificities to the TMs. For other promiscuous transporters such as the multiple-sugar transporter Msm of Streptococcus mutans, the PBP has a wide substrate specificity. These transporters include the maltose-maltodextrin, phosphate and sulfate transporters, among others.


Pssm-ID: 119394 [Multi-domain]  Cd Length: 190  Bit Score: 77.32  E-value: 2.30e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502862603  29 FQVTVALSITAWIIAFLVGSLFGILRTVPNRFLSSIGTLYVELFRNVPLIVQFFTWYLVVPELLPENIgmwfkseldpNV 108
Cdd:cd06261    1 LLNTLLLALIATLLALVLGLLLGIILARKRGKLDRLLRRIIDLLLSLPSLVLGLLLVLLFGVLLGWGI----------LP 70

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502862603 109 QFFVSSMMCLGLFTAARVCEQVRAAIQSLPRGQKNAGLAMGLTLPQTYRYVLLPNAYRVIVPPMTSEMMNLVKNSAIAST 188
Cdd:cd06261   71 GLGLPALILALLLIAPFARLIRRAALESIPKDLVEAARALGASPWQIFRRIILPLALPPILTGLVLAFARALGEFALVSF 150

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|
gi 502862603 189 IGLVDMAAQAGKLLDYSAHAWESFTAITLAYVLINAFIML 228
Cdd:cd06261  151 LGGGEAPGPGTGLLLIFAILFPGDLGVAAAVALILLLLSL 190
BPD_transp_1 pfam00528
Binding-protein-dependent transport system inner membrane component; The alignments cover the ...
 47-238 1.08e-13

Binding-protein-dependent transport system inner membrane component; The alignments cover the most conserved region of the proteins, which is thought to be located in a cytoplasmic loop between two transmembrane domains. The members of this family have a variable number of transmembrane helices.


Pssm-ID: 334128 [Multi-domain]  Cd Length: 183  Bit Score: 67.32  E-value: 1.08e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502862603   47 GSLFGIL-RTVPNRFLSSIGTLYVELFRNVPLIVqfftwylVVPELLPENIGMWFKSeldpnvqFFVSSMMCLGLFTAAR 125
Cdd:pfam00528   1 GIPLGIIaALRRGRRLDRLLRPLIDLLQALPSFV-------LAILLVVIAILSILGH-------GILPAIILALLGWAGY 66

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502862603  126 VCEQVRAAIQSLPRGQKNAGLAMGLTLPQTYRYVLLPNAYRVIVPPMTSEMMNLVKNSAIASTI----GLVDMAAQAGKL 201
Cdd:pfam00528  67 ARLIRRAALRSLPSDLVEAARALGASRWQIFRKIILPNALPPILTGLALAFGGALGGAVLLEFLgswpGLGLLLIEAILG 146

                         170       180       190
                  ....*....|....*....|....*....|....*..
gi 502862603  202 LDYSAHAWeSFTAITLAYVLINAFIMLVMNLVERKIR 238
Cdd:pfam00528 147 YDYPEIQG-PVLAAALILLLLNLLVDILQRLLDPRVR 182
 
Name Accession Description Interval E-value
HisM COG0765
ABC-type amino acid transport system, permease component [Amino acid transport and metabolism]; ...
 4-240 9.39e-66

ABC-type amino acid transport system, permease component [Amino acid transport and metabolism];


Pssm-ID: 440528 [Multi-domain]  Cd Length: 218  Bit Score: 203.00  E-value: 9.39e-66
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502862603   4 DWNWGIFLQqapfgnttYLGWLWSGFQVTVALSITAWIIAFLVGSLFGILRTVPNRFLSSIGTLYVELFRNVPLIVQFFT 83
Cdd:COG0765    2 FFDFSVLLD--------YLPLLLEGLLVTLLLTVLAIVLGLVLGLLLALARLSPNPVLRWLATAYVEFFRGTPLLVQLFF 73

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502862603  84 WYLVVPELlpeniGMwfksELDPnvqfFVSSMMCLGLFTAARVCEQVRAAIQSLPRGQKNAGLAMGLTLPQTYRYVLLPN 163
Cdd:COG0765   74 IYFGLPLL-----GI----DLSP----FVAAVIALTLNSAAYLAEIVRAGIQSVPKGQWEAARALGLSRWQTMRRIILPQ 140

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 502862603 164 AYRVIVPPMTSEMMNLVKNSAIASTIGLVDMAAQAGKLLDYSAHAWESFTAITLAYVLINAFIMLVMNLVERKIRLP 240
Cdd:COG0765  141 ALRIILPPLGNEFISLLKDTSLVSVIGVPELTRAAQQIASRTFRPFEVYLVAALIYLVLTLPLSLLARRLERRLARG 217
BatB COG4597
ABC-type amino acid transport system, permease component [Amino acid transport and metabolism]; ...
 20-239 1.16e-31

ABC-type amino acid transport system, permease component [Amino acid transport and metabolism];


Pssm-ID: 443651 [Multi-domain]  Cd Length: 397  Bit Score: 119.87  E-value: 1.16e-31
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502862603  20 TYLGWLWSGFQVTVALSITAWIIAFLVGSLFGILRTVPNRFLSSIGTLYVELFRNVPLIVQFFTWYLVVPELLPE----- 94
Cdd:COG4597   83 TYGRAFLVGLLNTLLVAVLGIVLATILGFLVGIARLSSNWLVSKLATVYVEIFRNIPLLLQIFFWYFAVLEALPSprqsl 162

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502862603  95 ---------NIGMWF-KSELDPNVQFFVSSM-----------------------------MCLGLF-------------- 121
Cdd:COG4597  163 slfdgvflnNRGLYLpAPVFEPGFGWVLAALlaaivaafvlrrwarrrqeatgqrfpvwwISLALLvglpllaflllgap 242

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502862603 122 ---------------------------------TAARVCEQVRAAIQSLPRGQKNAGLAMGLTLPQTYRYVLLPNAYRVI 168
Cdd:COG4597  243 lsldypelkgfnfrggltlspefvalllalslyTAAFIAEIVRAGIQAVSKGQTEAARALGLRPGQTLRLVVLPQALRVI 322

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 502862603 169 VPPMTSEMMNLVKNSAIASTIGLVDMAA-QAGKLLDYSAHAWESFTAITLAYVLINAFIMLVMNLVERKIRL 239
Cdd:COG4597  323 IPPLTSQYLNLTKNSSLAVAIGYPDLVSvFAGTTLNQTGQAIEIIAITMAVYLTISLLISLLMNWYNRRVAL 394
PRK15107 PRK15107
glutamate/aspartate ABC transporter permease GltK;
22-193 1.56e-26

glutamate/aspartate ABC transporter permease GltK;


Pssm-ID: 185062 [Multi-domain]  Cd Length: 224  Bit Score: 102.60  E-value: 1.56e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502862603  22 LGWLWSGFQVTVALSITAWIIAFLVGSLFGILRTVPNRFLSSIGTLYVELFRNVPLIVQFFTWYLVVPELLPENIGMWFK 101
Cdd:PRK15107  13 LPYLLDGLVITLKITVTAVVIGILWGTILAVMRLSSFKPVAWFAKAYVNVFRSIPLVMVLLWFYLIVPGFLQNVLGLSPK 92

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502862603 102 SELDpnvqfFVSSMMCLGLFTAARVCEQVRAAIQSLPRGQKNAGLAMGLTLPQTYRYVLLPNAYRVIVPPMTSEMMNLVK 181
Cdd:PRK15107  93 TDIR-----LISAMVAFSMFEAAYYSEIIRAGIQSISRGQSSAALALGMTHWQSMKLIILPQAFRAMVPLLLTQGIVLFQ 167

                        170
                 ....*....|..
gi 502862603 182 NSAIASTIGLVD 193
Cdd:PRK15107 168 DTSLVYVLSLAD 179
PRK15100 PRK15100
cystine ABC transporter permease;
11-237 3.68e-26

cystine ABC transporter permease;


Pssm-ID: 185055 [Multi-domain]  Cd Length: 220  Bit Score: 101.36  E-value: 3.68e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502862603  11 LQQAPFgnttylgwLWSGFQVTVALSITAWIIAFLVGSLFGILRTVPNRFLSSIGTLYVELFRNVPLIVQFFTWYLVVPE 90
Cdd:PRK15100   9 IDSAPF--------LLKGAGYTLQLSIGGMFFGLLLGFILALMRLSPIWPVRWLARFYVSIFRGTPLIAQLFMIYYGLPQ 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502862603  91 llpenigmwFKSELDPnvqfFVSSMMCLGLFTAARVCEQVRAAIQSLPRGQKNAGLAMGLTLPQTYRYVLLPNAYRVIVP 170
Cdd:PRK15100  81 ---------FGIELDP----IPAAMIGLSLNTAAYAAETLRAAISSIDKGQWEAAASIGMTRWQTLRRAILPQAARTALP 147

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502862603 171 PMTSEMMNLVKNSAIASTIGLVDMAAQAGKLldySAHAWESFT---AITLAYVLINAFIMLVMNLVERKI 237
Cdd:PRK15100 148 PLSNSFISLVKDTSLAATIQVPELFRQAQLI---TSRTLEVFTmylAASLIYWIMATVLSALQNRFENQL 214
glnP PRK09494
glutamine ABC transporter permease protein; Reviewed
 25-239 7.32e-25

glutamine ABC transporter permease protein; Reviewed


Pssm-ID: 181907 [Multi-domain]  Cd Length: 219  Bit Score: 97.82  E-value: 7.32e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502862603  25 LWSGFQVTVALSITAWIIAFLVGSLFGILRTVPNRFLSSIGTLYVELFRNVPLIVQFFTWYLVVPELLPEnigmwfkSEL 104
Cdd:PRK09494  15 LLEGAKMTLWISVLGLAGGLVIGLLAGFARAYGGWIANHIALVFIELIRGTPIVVQVMFIYFALPMAFND-------LRI 87

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502862603 105 DPNVQFFVSSMMCLGLFTAarvcEQVRAAIQSLPRGQKNAGLAMGLTLPQTYRYVLLPNAYRVIVPPMTSEMMNLVKNSA 184
Cdd:PRK09494  88 DPFTAAVVTIMINSGAYIA----EITRGAVLSIHKGFREAGLALGLSRRETLRYVIGPLALRRMLPPLGNQWIISIKDTS 163

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 502862603 185 IASTIGLVDMAAQAGKLLDYSAHAWESFTAITLAYVLINAFIMLVMNLVERKIRL 239
Cdd:PRK09494 164 LFIVIGVAELTRQGQEIIAGNFRALEIWSAVAVIYLIITLVLSFILRRLERRMKI 218
ectoine_ehuD TIGR03003
ectoine/hydroxyectoine ABC transporter, permease protein EhuD; Members of this family are ...
 25-237 5.46e-19

ectoine/hydroxyectoine ABC transporter, permease protein EhuD; Members of this family are presumed to act as permease subunits of ectoine ABC transporters. Operons containing this gene also contain the other genes of the ABC transporter and typically are found next to either ectoine utilization or ectoine biosynthesis operons.


Pssm-ID: 132048 [Multi-domain]  Cd Length: 212  Bit Score: 82.21  E-value: 5.46e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502862603   25 LWSGFQVTVALSITAWIIAFLVGSLFGILRTVPNRFLSSIGTLYVELFRNVPLIVQFFTWYLVVPellpeNIGMWFKSel 104
Cdd:TIGR03003  13 LIEGLKITILATALGFAIAAVLGLVFAILRRSAPTPISWPTSFVVEFIRGTPLLVQLYFLYYVLP-----DIGIRLPA-- 85

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502862603  105 dpnvqfFVSSMMCLGLFTAARVCEQVRAAIQSLPRGQKNAGLAMGLTLPQTYRYVLLPNAYRVIVPPMTSEMMNLVKNSA 184
Cdd:TIGR03003  86 ------LVAGVLGLGLHYATYAAEVYRAGIEAVPRGQWEAATALNLTARQTYRHIILPQAIPPIIPALGNYLVAMFKETP 159

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|...
gi 502862603  185 IASTIGLVDMAAQAGKLLDYSAHAWESFTAITLAYVLINAFIMLVMNLVERKI 237
Cdd:TIGR03003 160 VLSAITVLELMNQAKSIGNSTFRYLEPMTLVGVFFLILSIISVFFLRRLEARL 212
TM_PBP2 cd06261
Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding ...
 29-228 2.30e-17

Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and are mainly involved in importing solutes from the environment. The solute is captured by the PBP which delivers it to a gated translocation pathway formed by the two TMs. The two ABCs bind and hydrolyze ATP and drive the transport reaction. For these transporters the ABCs and TMs are on independent polypeptide chains. These systems transport a diverse range of substrates. Most are specific for a single substrate or a group of related substrates; however some transporters are more promiscuous, transporting structurally diverse substrates such as the histidine/lysine and arginine transporter in Enterobacteriaceae. In the latter case, this is achieved through binding different PBPs with different specificities to the TMs. For other promiscuous transporters such as the multiple-sugar transporter Msm of Streptococcus mutans, the PBP has a wide substrate specificity. These transporters include the maltose-maltodextrin, phosphate and sulfate transporters, among others.


Pssm-ID: 119394 [Multi-domain]  Cd Length: 190  Bit Score: 77.32  E-value: 2.30e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502862603  29 FQVTVALSITAWIIAFLVGSLFGILRTVPNRFLSSIGTLYVELFRNVPLIVQFFTWYLVVPELLPENIgmwfkseldpNV 108
Cdd:cd06261    1 LLNTLLLALIATLLALVLGLLLGIILARKRGKLDRLLRRIIDLLLSLPSLVLGLLLVLLFGVLLGWGI----------LP 70

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502862603 109 QFFVSSMMCLGLFTAARVCEQVRAAIQSLPRGQKNAGLAMGLTLPQTYRYVLLPNAYRVIVPPMTSEMMNLVKNSAIAST 188
Cdd:cd06261   71 GLGLPALILALLLIAPFARLIRRAALESIPKDLVEAARALGASPWQIFRRIILPLALPPILTGLVLAFARALGEFALVSF 150

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|
gi 502862603 189 IGLVDMAAQAGKLLDYSAHAWESFTAITLAYVLINAFIML 228
Cdd:cd06261  151 LGGGEAPGPGTGLLLIFAILFPGDLGVAAAVALILLLLSL 190
artM PRK11122
arginine ABC transporter permease ArtM;
21-237 2.09e-16

arginine ABC transporter permease ArtM;


Pssm-ID: 182978 [Multi-domain]  Cd Length: 222  Bit Score: 75.38  E-value: 2.09e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502862603  21 YLGWLWSGFQVTVALSITAWIIAFLVGSLFGILRTVPNRFLSSIGTLYVELFRNVPLIVQFF---------TWYLVVPEL 91
Cdd:PRK11122   4 YLPELLKGLHTSLTLTVASLLVALVLALIFTIILTLKTPVLVWLVRGYITLFTGTPLLVQIFliyygpgqfPWLQEYPWL 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502862603  92 LPENIGMWFkseldpnvqffvSSMMCLGLFTAARVCEQVRAAIQSLPRGQKNAGLAMGLTLPQTYRyVLLPNAYRVIVPP 171
Cdd:PRK11122  84 WHLLSQPWL------------CAMLALALNSAAYSTQLFYGAVRAIPEGQWQSCAALGMSKKQTLR-ILLPYAFKRALSS 150

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 502862603 172 MTSEMMNLVKNSAIASTIGLVDMAAQAGKLL--DYSAHAwesFTAITLAYVLINAFIMLVMNLVERKI 237
Cdd:PRK11122 151 YSNEVVLVFKSTSLAYTITLMDVMGYSQLLYgrTYDVMV---FGAAGIIYLVVNGLLTLLMRLIERKA 215
BPD_transp_1 pfam00528
Binding-protein-dependent transport system inner membrane component; The alignments cover the ...
 47-238 1.08e-13

Binding-protein-dependent transport system inner membrane component; The alignments cover the most conserved region of the proteins, which is thought to be located in a cytoplasmic loop between two transmembrane domains. The members of this family have a variable number of transmembrane helices.


Pssm-ID: 334128 [Multi-domain]  Cd Length: 183  Bit Score: 67.32  E-value: 1.08e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502862603   47 GSLFGIL-RTVPNRFLSSIGTLYVELFRNVPLIVqfftwylVVPELLPENIGMWFKSeldpnvqFFVSSMMCLGLFTAAR 125
Cdd:pfam00528   1 GIPLGIIaALRRGRRLDRLLRPLIDLLQALPSFV-------LAILLVVIAILSILGH-------GILPAIILALLGWAGY 66

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502862603  126 VCEQVRAAIQSLPRGQKNAGLAMGLTLPQTYRYVLLPNAYRVIVPPMTSEMMNLVKNSAIASTI----GLVDMAAQAGKL 201
Cdd:pfam00528  67 ARLIRRAALRSLPSDLVEAARALGASRWQIFRKIILPNALPPILTGLALAFGGALGGAVLLEFLgswpGLGLLLIEAILG 146

                         170       180       190
                  ....*....|....*....|....*....|....*..
gi 502862603  202 LDYSAHAWeSFTAITLAYVLINAFIMLVMNLVERKIR 238
Cdd:pfam00528 147 YDYPEIQG-PVLAAALILLLLNLLVDILQRLLDPRVR 182
HEQRo_perm_3TM TIGR01726
amine acid ABC transporter, permease protein, 3-TM region, His/Glu/Gln/Arg/opine family; This ...
 21-132 1.24e-13

amine acid ABC transporter, permease protein, 3-TM region, His/Glu/Gln/Arg/opine family; This model represents one of several classes of multiple membrane spanning regions found immediately N-terminal to the domain described by pfam00528, binding-protein-dependent transport systems inner membrane component. The region covered by this model generally is predicted to contain three transmembrane helices. Substrate specificities attributed to members of this family include histidine, arginine, glutamine, glutamate, and (in Agrobacterium) the opines octopine and nopaline. [Transport and binding proteins, Amino acids, peptides and amines]


Pssm-ID: 130787 [Multi-domain]  Cd Length: 99  Bit Score: 64.86  E-value: 1.24e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502862603   21 YLGWLWSGFQVTVALSITAWIIAFLVGSLFGILRTVPNRFLSSIGTLYVELFRNVPLIVQFFTWYLVVPEllpenigmwF 100
Cdd:TIGR01726   1 NLPFLLKGLLLTLLLSVLSILLGLVLGLLLALLRLSGNRPLRWIATVYVELFRGTPLLVQLFFIYFGLPL---------I 71

                          90       100       110
                  ....*....|....*....|....*....|..
gi 502862603  101 KSELDPnvqfFVSSMMCLGLFTAARVCEQVRA 132
Cdd:TIGR01726  72 GIRLSP----LTAAVIALTLFYGAYLAEIFRG 99
PRK15069 PRK15069
histidine ABC transporter permease HisM;
25-225 2.41e-12

histidine ABC transporter permease HisM;


Pssm-ID: 185029 [Multi-domain]  Cd Length: 234  Bit Score: 64.30  E-value: 2.41e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502862603  25 LWS-GFQVTvALSITAWI------IAFLVGSLFGILRTVPNRFLSSIGTLYVELFRNVPLIVQFFTWYlvvpellpenIG 97
Cdd:PRK15069  13 LWTdGYRFT-GLAITLWLlvasvvIGFVLAVPLAIARVSSNKWIRFPVWLYTYVFRGTPLYVQLLVFY----------TG 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502862603  98 MW---FKSELDPNVQFFVSSMMC----LGLFTAARVCEQVRAAIQSLPRGQKNAGLAMGLTLPQTYRYVLLPNAYRVIVP 170
Cdd:PRK15069  82 MYsleIVRGTDLLDAFFRSGLNCtilaFTLNTCAYTTEIFAGAIRSVPHGEIEAARAYGMSTFKLYRRIILPSALRRALP 161

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 502862603 171 PMTSEMMNLVKNSAIASTIGLVDMAAQAgklLDYSAHAWESFTA--------ITLAYVLINAF 225
Cdd:PRK15069 162 AYSNEVILMLHATTLAFTATVPDILKIA---RDINSATYQPFQAfgiaavlyLIISFVLISLF 221
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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