|
Name |
Accession |
Description |
Interval |
E-value |
| PTR2 |
COG3104 |
Dipeptide/tripeptide permease [Amino acid transport and metabolism]; |
6-506 |
4.22e-180 |
|
Dipeptide/tripeptide permease [Amino acid transport and metabolism];
Pssm-ID: 442338 [Multi-domain] Cd Length: 479 Bit Score: 514.36 E-value: 4.22e-180
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502863295 6 NQKESRTFFGHPYPLGSLFFTEMWERFSFYGIRPLLILFMAATVYDGGMGLARENASAIVGIFAGTMYLAALPGGWLADN 85
Cdd:COG3104 2 TSAPQRTFFGHPKGLYTLFFTEMWERFSFYGMRAILVLYLTASLADGGLGLSEADAAAIYGAYTALVYLTPLLGGWLADR 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502863295 86 WLGQQRAVWYGSILIALGHLSIALSAvmGNNLFFIGLMFIVLGSGLFKTCISVMVGTLYKKGDARRDGGFSLFYMGINMG 165
Cdd:COG3104 82 LLGQRRAILLGGILMALGHFLLALPG--GVTLFYLGLALIAVGNGLFKPNISSLVGQLYDPGDPRRDAGFTIFYMGINIG 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502863295 166 SFIAPLISGWLIKTHGWHWGFGIGGIGMLVALIIFRVFavpsmKRYDSEVGLDSTwnSPVVKRNGVGAWLLALAVGVAVL 245
Cdd:COG3104 160 AFLAPLLCGYLGEKYGWHYGFGAAAIGMLIGLIIFLLG-----RKYLGDIGLEPD--NPLSKKERLIAVALGALLLVLVL 232
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502863295 246 VtliaqgvIVINPVAVASMLVYVIAasVALYFIYLFIFAGLTRKERARLLVCFILLVSAAFFWSAFEQKPTSFNLFANDY 325
Cdd:COG3104 233 A-------GLLSNANIANYLLYVIA--IIAYFIFILRSKKLTKEERKRLLAILILFLFSIVFWALYEQAGTSLNLFADRN 303
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502863295 326 TNRMIGDFEIPAVWFQSINALFIILLAPVFSWAWPKLATMNIRPSSITKFVIGILCAAAGFGLMMLAAQnvLSNGGAGVS 405
Cdd:COG3104 304 VDRSLFGFEIPPSWFQSLNPLFIIILAPVFAALWTKLGKRGKEPSTPTKFALGLLLLGLGFLVMALAAL--LAGAGGKVS 381
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502863295 406 PFWLVGSILMLTLGELCLSPIGLATMTLLAPERMRGQMMGLWFCASALGNLAAGLIGGHVKADQldmLPDLFARCSIALL 485
Cdd:COG3104 382 PLWLVLAYLLLTIGELCLSPVGLSMITKLAPARFAGQMMGLWFLATALGNLLAGLLAGLYAVPG---YTAYFLLLGGIAL 458
|
490 500
....*....|....*....|.
gi 502863295 486 ICAAVLIVLIVPVRRMLENAR 506
Cdd:COG3104 459 VAGVVLLLLSPKLRRLMHGVE 479
|
|
| MFS_DtpA_like |
cd17346 |
Dipeptide and tripeptide permease A (DtpA)-like subfamily of the Major Facilitator Superfamily ... |
17-494 |
4.83e-133 |
|
Dipeptide and tripeptide permease A (DtpA)-like subfamily of the Major Facilitator Superfamily of transporters; The DtpA-like subfamily includes four Escherichia coli proteins: dipeptide and tripeptide permeases A (DtpA, TppB or YdgR), B (DtpB or YhiP), C (DtpC or YjdL), and D (DtpD or YbgH). They are proton-dependent permeases that transport di- and tripeptides. DtpA and DtpB display a preference for di- and tripeptides composed of L-amino acids. DtpC shows higher specificity for dipeptides compared to tripeptides, and prefers dipeptides containing a C-terminal lysine residue. The DtpA-like subfamily belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340904 [Multi-domain] Cd Length: 399 Bit Score: 391.55 E-value: 4.83e-133
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502863295 17 PYPLGSLFFTEMWERFSFYGIRPLLILFMAATVydgGMGLARENASAIVGIFAGTMYLAALPGGWLADNWLGQQRAVWYG 96
Cdd:cd17346 1 PKGLYTLFFTEMWERFSYYGMRAILILYLTAQL---GDGFSEADAASIYGAYTALVYLTPIIGGWLADKVLGARRTVFIG 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502863295 97 SILIALGHLSIALSAvMGNNLFFIGLMFIVLGSGLFKTCISVMVGTLYKKGDARRDGGFSLFYMGINMGSFIAPLISGWL 176
Cdd:cd17346 78 GILMALGYLLLALSP-FSVSMLYLGLALIIVGNGLFKPNISSLVGKLYDENDPRRDSGFSIFYMGINLGAFLAPLLCGTL 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502863295 177 IKTHGWHWGFGIGGIGMLVALIIFRVFAvpsmKRYdsevgldstwnspvvkrngvgawllalavgvavlvtliaqgvivi 256
Cdd:cd17346 157 GDNYGYHYGFGLAAVGMLLGLLIFLLGR----KKL--------------------------------------------- 187
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502863295 257 npvavasmlvyviaasvalyfiylfifagltrKERARLLVCFILLVSAAFFWSAFEQKPTSFNLFANDYTNRMIGDFEIP 336
Cdd:cd17346 188 --------------------------------LERKKMLAIIILFLFAVVFWAIYEQAGTSLALFADENVDRLLGGFTIP 235
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502863295 337 AVWFQSINALFIILLAPVFSWAWPKLATMNIRPSSITKFVIGILCAAAGFGLMMLAAQnvLSNGGAGVSPFWLVGSILML 416
Cdd:cd17346 236 PSWFQSLNPLFIILLAPILAALWTKLGKRGKDPSIPTKFALGLLLLGLSFLLMVLAAS--FAGGSGKVSALWLVLSYFLQ 313
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502863295 417 TLGELCLSPIGLATMTLLAPERMRGQMMGLWFCASALGNLAAGLIGGHVKADQ-----LDMLPDLFARCSIALLICAAVL 491
Cdd:cd17346 314 TLGELCLSPVGLSMITKLAPAKFAGFMMGLWFLASALGNILAGYLAGFYAQPKdplasALVYTDYFGLIGVIALVAGIIL 393
|
...
gi 502863295 492 IVL 494
Cdd:cd17346 394 LLL 396
|
|
| yjdL_sub1_fam |
TIGR00924 |
amino acid/peptide transporter (Peptide:H+ symporter), bacterial; The model describes ... |
11-502 |
1.52e-90 |
|
amino acid/peptide transporter (Peptide:H+ symporter), bacterial; The model describes proton-dependent oligopeptide transporters in bacteria. This model is restricted in its range in recognizing bacterial proton-dependent oligopeptide transporters, although they are found in yeast, plants and animals. They function by proton symport in a 1:1 stoichiometry, which is variable in different species. All of them are predicted to contain 12 transmembrane domains, for which limited experimental evidence exists. [Transport and binding proteins, Amino acids, peptides and amines]
Pssm-ID: 273342 [Multi-domain] Cd Length: 475 Bit Score: 285.19 E-value: 1.52e-90
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502863295 11 RTFFGHPYPLGSLFFTEMWERFSFYGIRPLLILFMaatVYDGGMGLARENASAIVGIFAGTMYLAALPGGWLADNWLGQQ 90
Cdd:TIGR00924 3 KTFFGHPKPLFTLFFVELWERFSYYGMQGILAVYL---VQQAGLGFSQEQAFIIFGAYSALVYLLTSVGWWFGDRVWGTK 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502863295 91 RAVWYGSILIALGHLSIALSAvmGNNLFFIGLMFIVLGSGLFKTCISVMVGTLYKKGDA-RRDGGFSLFYMGINMGSFIA 169
Cdd:TIGR00924 80 KTMVLGGIVLMLGHFMLAMSI--YPDLIFYGLGTIAVGSGLFKANPSSMVGKLYERGDMpRRDGGFTLFYMSINIGSFIS 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502863295 170 PLISGWLIKTHGWHWGFGIGGIGMLVALIIF-----RVFAVPSMKRYDSEVGLDStwnspvvkrngvGAWLLALAVGVAV 244
Cdd:TIGR00924 158 PLLAGVIAENYGYHVGFNLAAVGMVIGLLTFfagrhMLRDIGSVPDPLSGQGKTY------------GKLLLALLAALAL 225
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502863295 245 LVTLIaqgvIVINPVAVASMLVYVIAASVALYFIYLFIFAGLTRKERARLLVCFILLVSAAFFWSAFEQKPTSFNLFAND 324
Cdd:TIGR00924 226 VFFCA----WLMHHVVIANILLMTVTLAVIIFFFRLAFKPRLDAVARNKMYAYIVLFLEAVVFWVLYAQMPTSLNFFADN 301
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502863295 325 YTNRMIGDFEIPAVWFQSINALFIILLAPVFSWAWPKLATMNIRPSSITKFVIGILCAAAGFglMMLAAQNVLSNGGAGV 404
Cdd:TIGR00924 302 NMHHEMLGMSVPVIWFQSLNPFWVVVGSPVLAMIWTRLGRKGKDPTTPLKFTLGMLFCGASF--LTFAASIWFADAGGLT 379
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502863295 405 SPFWLVGSILMLTLGELCLSPIGLATMTLLAPERMRGQMMGLWFCASALGNLAAGLIGghVKADQLDMLPDLFARCSIAL 484
Cdd:TIGR00924 380 SPWFMVLIYLFQTLGELMISPLGLSWWTKIAPQRLMGQMLGMWFLAQAMGSLLGGYLA--TFGAVPQGVTGVFGKIGLVT 457
|
490
....*....|....*...
gi 502863295 485 LICAAVLIVLIVPVRRML 502
Cdd:TIGR00924 458 LLVGVVMALMVPWLNRMM 475
|
|
| PTR2 |
pfam00854 |
POT family; The POT (proton-dependent oligopeptide transport) family all appear to be proton ... |
91-461 |
2.67e-61 |
|
POT family; The POT (proton-dependent oligopeptide transport) family all appear to be proton dependent transporters.
Pssm-ID: 425909 [Multi-domain] Cd Length: 392 Bit Score: 206.02 E-value: 2.67e-61
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502863295 91 RAVWYGSILIALGHLSIALSAV------MGNNLFFIGLMFIVLGSGLFKTCISVMVGTLYKKGDARRDGG-FSLFYMGIN 163
Cdd:pfam00854 2 RTIFLGSIIYAIGHILLALSAIpslrppVHVALFFIGLALIALGTGGIKPNVSSFGGDQFEETDPRRRSRfFSIFYFSIN 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502863295 164 MGSFIAPLISGWLIKTHGWHWGFGIGGIGMLVALIIFrvFAVPSMKRydsEVGLDSTWNSPVVKRNGVGAWLLALAVGVA 243
Cdd:pfam00854 82 AGSLISTIITPYLQQNYGYPLGFGLPAVGMIIALLVF--LLGSRMYK---KKPPKGNVLTKVFKVLPVAAWNKVKLNGSS 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502863295 244 VLVTLIAQgvivinpVAVASMLVYVIAASVALYFIYLFIFAGLTRKE-RARLLVCFILLVSAAFFWSAFEQKPTSFNLFA 322
Cdd:pfam00854 157 AGIKKLHW-------LDWARELDALIILGIVVPGIFFNIWCTKTKVEeVKRLLRVLPLFLPLIMFWALYDQMGTSWVLQA 229
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502863295 323 NDyTNRMIGDFEIPAVWFQSINALFIILLAPVFSWAW-PKLATMNIRPSSITKFVIGILCAAAGFGLMMLAAQNVLSNGG 401
Cdd:pfam00854 230 RT-MNRKIGSFEIPPAQFQAFNAILVLIFIPIFDRLVyPLGRKCTGGLTPLQKMAVGLFLASLAFAIAAIVQLKRNDTGP 308
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 502863295 402 AG-------VSPFWLVGSILMLTLGELCLSPIGLATMTLLAPERMRGQMMGLWFCASALGNLAAGLI 461
Cdd:pfam00854 309 EFpiaqevpISVLWLIPQYLLIGFGELFISIGGLEFFYKLAPKSMTSLITGLFLLTNALGNFLSGVI 375
|
|
| tppB |
PRK09584 |
dipeptide/tripeptide permease DtpA; |
14-514 |
9.15e-58 |
|
dipeptide/tripeptide permease DtpA;
Pssm-ID: 181969 Cd Length: 500 Bit Score: 199.60 E-value: 9.15e-58
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502863295 14 FGHPYPLGSLFFTEMWERFSFYGIRPLLILFMAATvydggMGLARENASAIVGIFAGTMYLAALPGGWLADNWLGQQRAV 93
Cdd:PRK09584 17 FKQPKAFYLIFSIELWERFGYYGLQGIMAVYLVKQ-----LGMSEADSITLFSSFSALVYGLVAIGGWLGDKVLGTKRVI 91
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502863295 94 WYGSILIALGHLSIALSAvMGNNLFFIGLMFIVLGSGLFKTCISVMVGTLYKKGDARRDGGFSLFYMGINMGSFIAPLIS 173
Cdd:PRK09584 92 MLGAIVLAIGYALVAWSG-HDAGIVYMGMATIAVGNGLFKANPSSLLSTCYEKDDPRLDGAFTMYYMSINIGSFFSMLAT 170
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502863295 174 GWLIKTHGWHWGFGIGGIGMLVALIIFrVFAVPSMKRYDSEVGLdstwnSPVVKRNgvgawLLALAVGVAVLVTLIAqgv 253
Cdd:PRK09584 171 PWLAAKYGWSVAFALSVVGMLITVVNF-AFCQRWVKQYGSKPDF-----EPINYRK-----LLLTIVGVVALIAIAT--- 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502863295 254 IVINPVAVASMLVYVIAAS-VALYFIYLFIFAGLtrkERARLLVCFILLVSAAFFWSAFEQKPTSFNLFANDYTNRMIGD 332
Cdd:PRK09584 237 WLLHNQEIARMALGVVALGiVVIFGKEAFAMKGA---ARRKMIVAFILMLEAIIFFVLYSQMPTSLNFFAIRNVEHSILG 313
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502863295 333 FEIPAVWFQSINALFIILLAPVFSWAWPKLATMNIRPssiTKFVIGILCAAAGFGLMMLAAQnvLSNGGAGVSPFWLVGS 412
Cdd:PRK09584 314 IAVEPEQYQALNPFWIMIGSPILAAIYNKMGDRLPMP---HKFAIGMVLCSGAFLVLPLGAK--FANDAGIVSVNWLIAS 388
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502863295 413 ILMLTLGELCLSPIGLATMTLLAPERMRGQMMGLWFCASALGNLAAGLIGGHVKADQ--------LDMLPDLFARCSIAL 484
Cdd:PRK09584 389 YGLQSIGELMISGLGLAMVAQLVPQRLMGFIMGSWFLTTAGAALIAGYVANLMAVPDnvtdplmsLEVYGRVFLQIGIAT 468
|
490 500 510
....*....|....*....|....*....|.
gi 502863295 485 LICaAVLIVLIVP-VRRMLENARTKPATEAV 514
Cdd:PRK09584 469 AVI-AVLMLLTAPkLNRMTQDDSADKAAKAA 498
|
|
| PRK10207 |
PRK10207 |
dipeptide/tripeptide permease DtpB; |
16-503 |
5.76e-53 |
|
dipeptide/tripeptide permease DtpB;
Pssm-ID: 182306 Cd Length: 489 Bit Score: 186.56 E-value: 5.76e-53
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502863295 16 HPYPLGSLFFTEMWERFSFYGIRPLLILFMAATvydggMGLARENASAIVGIFAGTMYLAALPGGWLADNWLGQQRAVWY 95
Cdd:PRK10207 12 QPRPFFMIFFVELWERFGYYGVQGILAVFFVKQ-----LGFSQEQAFITFGAFAALVYGLISIGGYVGDHLLGTKRTIVL 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502863295 96 GSILIALGHLSIALSaVMGNNLFFIGLMFIVLGSGLFKTCISVMVGTLYKKGDARRDGGFSLFYMGINMGSFIAPLISGW 175
Cdd:PRK10207 87 GAIVLAIGYFMTGMS-LLKPDLIFIALGTIAVGNGLFKANPASLLSKCYPPKDPRLDGAFTLFYMSINIGSLISLSLAPV 165
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502863295 176 LIKTHGWHWGFGIGGIGMLVALIIFrvFAVPSMKRydsEVGLDSTwNSPVVKRNgvgawLLALAVGVAVLVTLIAQgviV 255
Cdd:PRK10207 166 IADKFGYSVTYNLCGAGLIIALLVY--FACRGMVK---DIGSEPD-HKPMSFSK-----LLLVLLGSVVMIFVCAW---L 231
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502863295 256 INPVAVASMLvyVIAASVALYFIYLFIFAGLTRKERARLLVCFILLVSAAFFWSAFEQKPTSFNLFANDYTNRMIGDFEI 335
Cdd:PRK10207 232 MHNVEVANLV--LIVLSIVVTIIFFREAFKLDKTGRNKMFVAFVLMLEAVVFYILYAQMPTSLNFFAINNVHHEILGFSI 309
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502863295 336 PAVWFQSINALFIILLAPVFSWAWPKLATMNIRPSSITKFVIGILCAAAGFgLMMLAAQNVLSNGGAGVSPFWLVGSILM 415
Cdd:PRK10207 310 NPVSFQALNPFWVVVASPILAGIYTHLGSKGKDLSMPMKFTLGMFLCSLGF-LTAAAAGMWFADAQGLTSPWFIVLVYLF 388
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502863295 416 LTLGELCLSPIGLATMTLLAPERMRGQMMGLWFCASAlgnlAAGLIGGHVKA---------DQLDMLP---DLFARCSIA 483
Cdd:PRK10207 389 QSLGELFISALGLAMIAALVPQHLMGFILGMWFLTQA----AAFLLGGYVATftavpdnitDPLETLPvytNVFGKIGLV 464
|
490 500
....*....|....*....|
gi 502863295 484 LLICAAVLIVLIVPVRRMLE 503
Cdd:PRK10207 465 TLGVAVVMALMVPWLNRMIN 484
|
|
| PRK15462 |
PRK15462 |
dipeptide permease; |
27-494 |
2.20e-52 |
|
dipeptide permease;
Pssm-ID: 237971 [Multi-domain] Cd Length: 493 Bit Score: 185.15 E-value: 2.20e-52
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502863295 27 EMWERFSFYGIRPLLILFMAATV-YDGgmglarENASAIVGIFAGTMYLAALPGGWLADNWLGQQRAVWYGSILIALGHL 105
Cdd:PRK15462 18 QIWEYFSFYGMRALLILYLTNQLkYDD------NHAYELFSAYCSLVYVTPILGGFLADKVLGNRMAVMLGALLMAIGHV 91
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502863295 106 SIALSAVmGNNLFFIGLMFIVLGSGLFKTCISVMVGTLYKKGDARRDGGFSLFYMGINMGSFIAPLISGWLIKTHGWHWG 185
Cdd:PRK15462 92 VLGASEI-HPSFLYLSLAIIVCGYGLFKSNVSCLLGELYEPTDPRRDGGFSLMYAAGNVGSIIAPIACGYAQEEYSWAMG 170
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502863295 186 FGIGGIGMLVALIIFrvfaVPSMKRYDSEVGLDstwNSPVVKRNGV---GAWLLALAVGVAVLVTliaqgVIVINPVAVA 262
Cdd:PRK15462 171 FGLAAVGMIAGLVIF----LCGNRHFTHTRGVN---KKVLRATNFLlpnWGWLLVLLVATPALIT-----VLFWKEWSVY 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502863295 263 SMLVYVIAASVALYFIYLfifAGLTRKERARLLVCFILLVSAAFFWSAFEQKPTSFNLFANDYTNRMIGDFEIPAVWFQS 342
Cdd:PRK15462 239 ALIVATIIGLGVLAKIYR---KAENQKQRKELGLIVTLTFFSMLFWAFAQQGGSSISLYIDRFVNRDMFGYTVPTAMFQS 315
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502863295 343 INALFIILLAPVFSWAWPKLATMNIRPSSITKFVIGILCAAAGFGLMMLAAQNVLSNGGAGVsPFWLVGSILMlTLGELC 422
Cdd:PRK15462 316 INAFAVMLCGVFLAWVVKESVAGNRTVRIWGKFALGLGLMSAGFCILTLSARWSAMYGHSSL-PLMVLGLAVM-GFAELF 393
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502863295 423 LSPIGLATMTLLAPERMRGQMMGLWFCAS-ALGNLAAGLIGGHVKADQLD----------MLPDLFARCSIALLICAAVL 491
Cdd:PRK15462 394 IDPVAMSQITRIEIPGVTGVLTGIYMLLSgAIANYLAGVIADQTSQASFDasgainysinAYIEVFDQITWGALACVGVV 473
|
...
gi 502863295 492 IVL 494
Cdd:PRK15462 474 LMI 476
|
|
| MFS_SLC15A1_2_like |
cd17347 |
Solute carrier family 15 members 1 and 2, and similar Major Facilitator Superfamily ... |
26-456 |
1.97e-40 |
|
Solute carrier family 15 members 1 and 2, and similar Major Facilitator Superfamily transporters; Solute carrier family 15 member 1 (SLC15A1) and SLC15A2 are members of the proton-coupled oligopeptide transporter (POT) family of integral membrane proteins that mediate the cellular uptake of di/tripeptides and peptide-like drugs. They mediate the proton-coupled active transport of a broad range of dipeptides and tripeptides, including zwitterionic, anionic and cationic peptides, as well as a variety of peptide-like drugs such as cefadroxil, enalapril, and valacyclovir. SLC15A1, or peptide transporter 1 (PepT1), is primarily expressed in the brush border membranes of enterocytes of the small intestine and is also known as the intestinal isoform. SLC15A2, or peptide transporter 2 (PepT2), is abundantly expressed in the apical membrane of kidney proximal tubules and is also referred to as the renal isoform. Both proteins transport di/tripeptides, but not tetrapeptides or free amino acids, using the energy generated by an inwardly directed transmembrane proton gradient. The SLC15A1/SLC15A2-like group belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340905 [Multi-domain] Cd Length: 427 Bit Score: 150.85 E-value: 1.97e-40
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502863295 26 TEMWERFSFYGIRPLLILFMaatVYDGGMGLARenASAIVGIFAGTMYLAALPGGWLADNWLGQQRAVWYGSILIALGHL 105
Cdd:cd17347 10 NEFCERFSYYGMRAILVLYL---TDFLGFSEAE--ATAIYHSFVMLCYFFPLLGAIIADSYLGKYRTILYLSLVYCLGHI 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502863295 106 SIALSAVMGNN-----LFFIGLMFIVLGSGLFKTCISVMVGTLYKKGDAR-RDGGFSLFYMGINMGSFIAPLISGWL--- 176
Cdd:cd17347 85 VLAVTAIPPLGpphvwGLLIGLLLIAIGTGGIKPCVSAFGGDQFGADQQHlLARFFSWFYFAINAGSLLSTFLTPILrad 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502863295 177 ---IKTHGWHWGFGIGGIGMLVALIIFRVfavpSMKRYdsevgldstwnspvvkrngvgawllalavgvavlvtliaqgv 253
Cdd:cd17347 165 vqfGGHDCYPLAFGVPGVLMAVATLVFWL----GRKHY------------------------------------------ 198
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502863295 254 ivinpVAVASMLvyviaasvalyfiylfifagltrkeraRLLVCFILLvsaAFFWSAFEQKPTSFNLFANDyTNRMIGDF 333
Cdd:cd17347 199 -----KDVKALL---------------------------RVLVLFIPL---PVFWALFDQQGSRWTLQAEQ-MDGLVGGF 242
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502863295 334 EIPAVWFQSINALFIILLAPVFS-WAWPKLATMNIRPSSITKFVIGILCAAAGFGL----------------MMLAAQNV 396
Cdd:cd17347 243 TILPDQMQALNPILILILIPLFDyVIYPLLERCGIPLTPLRKMGVGMILAALAFVIagflqlridgglpgqpDPGEVTTF 322
|
410 420 430 440 450 460
....*....|....*....|....*....|....*....|....*....|....*....|
gi 502863295 397 LSNGGAGVSPFWLVGSILMLTLGELCLSPIGLATMTLLAPERMRGQMMGLWFCASALGNL 456
Cdd:cd17347 323 EDIEPNSVSILWQLPQYVVLTAGEVLFSITGLEFAYTQAPKSMKSVVQAAWLLTVALGNL 382
|
|
| MFS_POT |
cd06175 |
Proton-coupled oligopeptide transporter (POT) family of the Major Facilitator Superfamily of ... |
26-461 |
2.26e-39 |
|
Proton-coupled oligopeptide transporter (POT) family of the Major Facilitator Superfamily of transporters; The Proton-coupled oligopeptide transporter (POT) family is present across all major kingdoms of life and is known by a variety of names. It is referred to as the Nitrate transporter/Peptide transporter (NRT1/PTR) family (NPF) in plants, and in addition to POT, it is also known as the Peptide transporter (PepT/PTR) or Solute Carrier 15 (SLC15) family in animals. Members of this family are proton-driven symporters involved in nitrogen acquisition in the form of di- and tripeptides. Plant members transport other nitrogenous ligands including nitrate, the plant hormone auxin, and glucosinolate compounds that are important for seed defense. POT proteins exhibit substrate multispecificity, with one transporter able to recognize as many as 8,400 types of di/tripeptides and certain peptide-like drugs. The POT family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340865 [Multi-domain] Cd Length: 422 Bit Score: 147.97 E-value: 2.26e-39
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502863295 26 TEMWERFSFYGIRPLLILFMaatvyDGGMGLARENASAIVGIFAGTMYLAALPGGWLADNWLGQQRAVWYGSILIALGHL 105
Cdd:cd06175 7 IELCERFTFYGIGANLVPFL-----TGALGLGNAQAANVVLNFLGTSYVTPLFGGWIADTFLGRYRTILIGAAIYAVGVA 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502863295 106 SIALSAVMGNN-------------------LFFIGLMFIVLGSGLFKTCISVMVGTLYKK-GDARRDGGFSLFYMGINMG 165
Cdd:cd06175 82 ILTVSTIPPGLrplrcnpshceqasgiqltGFYAALYLIALGTGGVKANVSPLGADQFDErGPSKTQSFFNWFYFCINVG 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502863295 166 SFIAPLISGWLIKTHGWHWGFGIGGIGMLVALIIFrvfavpsmkrydsevgldstwnspvvkrngvgawllalavgvavl 245
Cdd:cd06175 162 SLLAMLGTPYIQDNVGWAAAYGIPFVAILLALVVF--------------------------------------------- 196
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502863295 246 vtliaqgvivinpvavasmlvyviaasvalyfiylfifagltrkERARLLVCFILLVSAAFFWSAFEQKPTSFNLFANDy 325
Cdd:cd06175 197 --------------------------------------------EVKQLLRALPLFAFCILFWTVYAQMTTSYVLQALT- 231
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502863295 326 TNRMIGDFEIPAVWFQSINALFIILLAPVFSW-AWPKLATMNIRPSSITKFVIGIL------CAAAGFGLMML--AAQNV 396
Cdd:cd06175 232 LVRSTGLFTIPPASMQAFNPILLLLLIPVLDKvVYPLIRRYGVGLSPLTKIGLGFFfgslsmFVAGFLELKRLntAHAHG 311
|
410 420 430 440 450 460
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 502863295 397 LSNGGAGVSPFWLVGSILMLTLGELCLSPIGLATMTLLAPERMRGQMMGLWFCASALGNLAAGLI 461
Cdd:cd06175 312 PVVTTSPLSFWWQIPQYLLLGIGEILVSITGLEFAYREAPKSMKGFIMGLLLLTSGFGSFFGSVL 376
|
|
| MFS_SLC15A1 |
cd17412 |
Solute Carrier family 15 member 1 of the Major Facilitator Superfamily of transporters; Solute ... |
22-491 |
2.19e-20 |
|
Solute Carrier family 15 member 1 of the Major Facilitator Superfamily of transporters; Solute carrier family 15 member 1 (SLC15A1), also called peptide transporter 1 (PepT1), is a member of the proton-coupled oligopeptide transporter (POT) family of integral membrane proteins that mediate the cellular uptake of di/tripeptides and peptide-like drugs. SLC15A1, as well as SLC15A2, mediate the proton-coupled active transport of a broad range of dipeptides and tripeptides, including zwitterionic, anionic and cationic peptides, as well as a variety of peptide-like drugs such as cefadroxil, enalapril, and valacyclovir. SLC15A1 is primarily expressed in the brush border membranes of enterocytes of the small intestine and is also known as the intestinal isoform. It is a high-capacity/low-affinity transporter that drives the transport of di-and tripeptides for metabolic purposes. It's expression is upregulated in the colon during chronic inflammation associated with inflammatory bowel disease. SLC15A1/PepT1 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340970 [Multi-domain] Cd Length: 415 Bit Score: 93.37 E-value: 2.19e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502863295 22 SLFF---TEMWERFSFYGIRPLLILFmaatvYDGGMGLARENASAIVGIFAGTMYLAALPGGWLADNWLGQQRAVWYGSI 98
Cdd:cd17412 3 SIFFivvNEFCERFSYYGMRAVLVLY-----FKYFLRWDDDLSTAIYHTFVALCYLTPILGAIIADSWLGKFKTIVYLSI 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502863295 99 LIALGHLSIALSAV---MGNN-------------LFFIGLMFIVLGSGLFKTCISVMVGTLYKKG-DARRDGGFSLFYMG 161
Cdd:cd17412 78 VYTIGQAVMAVSAIhdlTDANrdgtpdnltlhvaLSMIGLLLIALGTGGIKPCVAAFGGDQFEEHqEKQRSRFFSIFYLS 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502863295 162 INMGSFIAPLIS--------GWLIKTHGWHWGFGIGGIGMLVALIIFrvfavpsmkrydsevgldstwnspvvkrngvga 233
Cdd:cd17412 158 INAGSLLSTIITpilrsqecGIHSKQKCYPLAFGVPAALMVVALIVF--------------------------------- 204
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502863295 234 wllalavgvavlvtliaqgvivinpvAVASMLVYVIAASVALYFIYlfifagltrkerarllvcfillVSAAFFWSAFEQ 313
Cdd:cd17412 205 --------------------------ILGSKMYKQIKMVLKVLFLY----------------------IPLPMFWALFDQ 236
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502863295 314 KPTSFNLFANDYTNRmIGDFEIPAVWFQSINALFIILLAPVFSWA-WPKLATMNIRPSSITKFVIGILCAAAGFGLMMLA 392
Cdd:cd17412 237 QGSRWTLQATTMDGN-FGAIQIQPDQMQTVNPILIIIMVPIFDAViYPLIKKCKINFTPLRKMTVGMFLAALAFVAAALL 315
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502863295 393 AqnvlsnggagVSPFWLVGSILMLTLGELCLSPIGLATMTLLAPERMRGQMMGLWFCASALGNLAAGLIGGHVKADQLDM 472
Cdd:cd17412 316 Q----------IQMAWQIPQYFLLTCGEVVFSVTGLEFSYSQAPSNMKSVLQAGWLLTVAVGNIIVLIVAEAGSISEQWA 385
|
490
....*....|....*....
gi 502863295 473 LPDLFARCSIALLICAAVL 491
Cdd:cd17412 386 EYVLFAALLVAVCIIFAIM 404
|
|
| MFS_NPF |
cd17351 |
Plant NRT1/PTR family (NPF) of the Major Facilitator Superfamily of transporters; The plant ... |
23-461 |
3.43e-19 |
|
Plant NRT1/PTR family (NPF) of the Major Facilitator Superfamily of transporters; The plant Nitrate transporter/Peptide transporter (NRT1/PTR) family (NPF) is related to the POT (proton-coupled oligopeptide transporter), Peptide transporter (PepT/PTR), or Solute Carrier 15 (SLC15) family in animals. In contrast to related animal and bacterial counterparts, the plant proteins transport a wide variety of substrates including nitrate, peptides, amino acids, dicarboxylates, glucosinolates, as well as the plant hormones indole-3-acetic acid (IAA) and abscisic acid (ABA). A recent study identified eight subfamilies within this family, named NPF1-NPF8. NPF belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340909 [Multi-domain] Cd Length: 445 Bit Score: 89.99 E-value: 3.43e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502863295 23 LFFTEMWERFSFYGIRPLLILFMAATvydggMGLARENASAIVGIFAGTMYLAALPGGWLADNWLGQQRAVWYGSILIAL 102
Cdd:cd17351 4 ILGNEFAERLAFYGIAVNLVTYLTKV-----MHLSNAKAANTVTNFSGTSYLTPLLGAFLADAYLGRYWTIAIFSVIYLV 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502863295 103 GHLSIALSAVM--------------------GNNLFFIGLMFIVLGSGLFKTCISVMVGTLYKKGD----ARRDGGFSLF 158
Cdd:cd17351 79 GLILLTLSASVpslrpppcnpdspcepasstQLTVLYVGLYLIALGTGGIKPCVSAFGADQFDETDpkekKQKPSFFNWF 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502863295 159 YMGINMGSFIAPLISGWLIKTHGWHWGFGIGGIGMLVALIIFrvFAVPSMKRydsevgldstwnspVVKRngvgawllal 238
Cdd:cd17351 159 YFSINLGSLLAVTLVVYIQDNVSWGWGFGIPAAAMALAVIVF--VAGTPFYR--------------EVKC---------- 212
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502863295 239 avgvavlvtliaqgVIVINPVAVASMLVYVIAASVALYFIylfifagltrkerarllvcfillvsaaffwsafeQKPTSF 318
Cdd:cd17351 213 --------------LLRLLPIWATTILLSTVYAQMQTFFV----------------------------------QQGLTM 244
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502863295 319 NLfandytnRMIGDFEIPAVWFQSINALFIILLAPVF-SWAWPKLATMNIRPSSITK-------FVIGILC-AAAGF--- 386
Cdd:cd17351 245 DR-------RLGGSFEIPAASLSVFSTLFVLLFIPLYdRVFVPFARRYTGNPRGITPlqrigigLVLSILAmAVAALvev 317
|
410 420 430 440 450 460 470
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 502863295 387 GLMMLAAQNVLSNGGAGVSP---FWLVGSILMLTLGELCLSPIGLATMTLLAPERMRGQMMGLWFCASALGNLAAGLI 461
Cdd:cd17351 318 KRLRVARAHGLLDSPTGVVPmsvFWLLPQYFLLGLAEVFTYIGQLEFFYDEAPDGMRSLGTALFLLTIALGNFLSSAL 395
|
|
| 2A1704 |
TIGR00926 |
Peptide:H+ symporter (also transports b-lactam antibiotics, the antitumor agent, bestatin, and ... |
32-388 |
4.15e-18 |
|
Peptide:H+ symporter (also transports b-lactam antibiotics, the antitumor agent, bestatin, and various protease inhibitors); [Transport and binding proteins, Amino acids, peptides and amines]
Pssm-ID: 273343 [Multi-domain] Cd Length: 654 Bit Score: 87.51 E-value: 4.15e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502863295 32 FSFYGIRPLLILFMAATvydggMGLARENASAIVGIFAGTMYLAALPGGWLADNWLGQQRAVWYGSILIALGHLSIALSA 111
Cdd:TIGR00926 1 FSYYGMRTILVLYFLNF-----LGFSESTSTVLFHTFTYLCYLTPLIGAIIADGWLGKFKTILYLSIVYVVGHALLSFGA 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502863295 112 V------MGNNLFFIGLMFIVLGSGLFKTCISVMVGTLYKKGDAR-RDGGFSLFYMGINMGS----FIAPLISGWLIKTH 180
Cdd:TIGR00926 76 IpssghpLHDLLDLLGLALIALGTGGIKPCVSAFGGDQFEERQLSlRSRFFSFFYFAINAGSlistIITPILRGDVGCFG 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502863295 181 GWHWGFGIGGIGMLVALIIFRVFAvpsmkrydsevgLDSTWNSPVVKRNGVGAWLLALAVGvavlvtliAQGVIVINPVA 260
Cdd:TIGR00926 156 CQDCYPLAFGVPAILMILALIVFM------------AGSKMYKKKPPKGNIVSKVIKCIVT--------ALRKRFSTRSE 215
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502863295 261 VASMLVYVIAASVALYFIYlfifagltrKERARLLVCFILLVSAAFFWSAFEQKPTSFNLFANDYTNRmIGDFEIPAVWF 340
Cdd:TIGR00926 216 HWPLHWLDYAKDKHDIRMI---------RSTKRLLRVLVLFIPLPMFWALFDQQGSRWTLQATRMDGD-VGGFEIQPDQM 285
|
330 340 350 360
....*....|....*....|....*....|....*....|....*....
gi 502863295 341 QSINALFIILLAPVF-SWAWPKLATMNIRPSSITKFVIGILCAAAGFGL 388
Cdd:TIGR00926 286 QVVNPLLILIFVPIFdYIVYPAIAKCGTRFTSLRKMAVGGLLAALSFFV 334
|
|
| MFS_SLC15A2 |
cd17411 |
Solute carrier family 15 member 2 of the Major Facilitator Superfamily of transporters; Solute ... |
17-456 |
1.55e-17 |
|
Solute carrier family 15 member 2 of the Major Facilitator Superfamily of transporters; Solute carrier family 15 member 2 (SLC15A2), also called peptide transporter 2 (PepT2), is a member of the proton-coupled oligopeptide transporter (POT) family of integral membrane proteins that mediate the cellular uptake of di/tripeptides and peptide-like drugs. SLC15A2, as well as SLC15A1, mediate the proton-coupled active transport of a broad range of dipeptides and tripeptides, including zwitterionic, anionic and cationic peptides, as well as a variety of peptide-like drugs such as cefadroxil, enalapril, and valacyclovir. SLC15A2 is a high-affinity transporter and is abundantly expressed in the apical membrane of kidney proximal tubules and choroid plexus epithelial cells. It is the major transporter involved in the reclamation of peptide-bound amino acids and peptide-like drugs in the kidney, and is also called the renal isoform. In choroid plexus and the brain, it acts as an efflux transporter and plays a role in regulating peptide/neuropeptide homeostasis. SLC15A2/PepT2 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340969 [Multi-domain] Cd Length: 403 Bit Score: 84.49 E-value: 1.55e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502863295 17 PYPLGSLFFTEMWERFSFYGIRPLLIL-FMAATVYDGGMglarenASAIVGIFAGTMYLAALPGGWLADNWLGQQRAVWY 95
Cdd:cd17411 1 PLSIAFIVVNEFCERFSYYGMKAVLTLyFLSFLHWDENL------STAIYHAFSGLCYFTPVLGALIADSWLGKFKTIIY 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502863295 96 GSILIALGHLSIALSAV--MGNN-----LFFIGLMFIVLGSGLFKTCISVMVGTLYKKGDAR-RDGGFSLFYMGINMGSF 167
Cdd:cd17411 75 LSIVYVVGHVIKSVGAIptVGDQqvhvvLSMIGLFLIALGTGGIKPCVAAFGGDQFEEEHAReRSKFFSIFYLSINAGSL 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502863295 168 IaplisgwlikthgwhwgfgiggigmlvaliifrvfavpsmkrydsevgldSTWNSPVVKRN--GVGAWLLALAVGVAVL 245
Cdd:cd17411 155 I--------------------------------------------------STFVTPILRGDvqCFGGDCYALAFGVPAA 184
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502863295 246 VTLIAqgvivinpvavasmLVYVIAASvalyfiylfifaGLTRKERARLLVCFiLLVSAAFFWSAFEQKPTSFNLFANDy 325
Cdd:cd17411 185 LMVVA--------------LVVFIAGS------------GMYKEVKMVTRVLF-LYIPLPMFWALFDQQGSRWTLQATR- 236
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502863295 326 TNRMIGDFEIPAVWFQSINALFIILLAPVFSWA-WPKLATMNIRPSSITKFVIGILCAAAGFGLMMLAAQNVLsnggagv 404
Cdd:cd17411 237 MNDFGGGFVLQPDQMQTLNPLLILVFIPIFDLGiYPLVSKCKINFTSLRKMATGMILAALAFAVAAAVEIKIA------- 309
|
410 420 430 440 450
....*....|....*....|....*....|....*....|....*....|..
gi 502863295 405 spfWLVGSILMLTLGELCLSPIGLATMTLLAPERMRGQMMGLWFCASALGNL 456
Cdd:cd17411 310 ---WQLPQYVLLSAGEVMFSITGLEFSYSQAPASMKSVLQAGWLLTVAFGNV 358
|
|
| MFS_NPF8 |
cd17418 |
NRT1/PTR family (NPF), subfamily 8 of the Major Facilitator Superfamily of transporters; The ... |
17-200 |
9.32e-15 |
|
NRT1/PTR family (NPF), subfamily 8 of the Major Facilitator Superfamily of transporters; The plant Nitrate transporter/Peptide transporter (NRT1/PTR) family (NPF) is related to the POT (proton-coupled oligopeptide transporter), Peptide transporter (PepT/PTR), or Solute Carrier 15 (SLC15) family in animals. In contrast to related animal and bacterial counterparts, the plant proteins transport a wide variety of substrates including nitrate, peptides, amino acids, dicarboxylates, glucosinolates, as well as the plant hormones indole-3-acetic acid (IAA) and abscisic acid (ABA). A recent study identified eight subfamilies within this family, named NPF1-NPF8. NPF8 contains the Arabidopsis dipeptide transporters AtNPF8.1 (PTR1), AtNPF8.2 (PTR5), and AtNPF8.3 (PTR2), as well as tonoplast-localized transporters AtNPF8.4 (PTR4) and AtNPF8.5 (PTR6). Oryza sativa NRT1 (now called OsNPF8.9) is a low-affinity nitrate transporter. NPF8 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340976 [Multi-domain] Cd Length: 447 Bit Score: 76.36 E-value: 9.32e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502863295 17 PYPLGslffTEMWERFSFYGIRPLLILFMAATVYDGGMGLAREnasaiVGIFAGTMYLAALPGGWLADNWLGQQRAVWYG 96
Cdd:cd17418 5 PFILG----NECCERLAYYGIATNLITYLTKELHQGNVSAANN-----VTNWSGTCYITPLIGAFIADAYWGRYWTIASF 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502863295 97 SILIALGHLSIALSAVMGN-------------------NLFFIGLMFIVLGSGLFKTCISVMVGTLYKKGDA----RRDG 153
Cdd:cd17418 76 SAIYFIGMVLLTLSASVPGlkpascigslcppatsvqyAVFFLGLYLIALGTGGIKPCVSSFGADQFDDTDPkekvRKSS 155
|
170 180 190 200
....*....|....*....|....*....|....*....|....*..
gi 502863295 154 GFSLFYMGINMGSFIAPLISGWLIKTHGWHWGFGIGGIGMLVALIIF 200
Cdd:cd17418 156 FFNWFYFSINIGALISSSVLVWIQENVGWGWGFGIPTVFMGIAIVSF 202
|
|
| MFS_NPF5 |
cd17417 |
NRT1/PTR family (NPF), subfamily 5 of the Major Facilitator Superfamily of transporters; The ... |
27-200 |
4.98e-14 |
|
NRT1/PTR family (NPF), subfamily 5 of the Major Facilitator Superfamily of transporters; The plant Nitrate transporter/Peptide transporter (NRT1/PTR) family (NPF) is related to the POT (proton-coupled oligopeptide transporter), Peptide transporter (PepT/PTR), or Solute Carrier 15 (SLC15) family in animals. In contrast to related animal and bacterial counterparts, the plant proteins transport a wide variety of substrates including nitrate, peptides, amino acids, dicarboxylates, glucosinolates, as well as the plant hormones indole-3-acetic acid (IAA) and abscisic acid (ABA). A recent study identified eight subfamilies within this family, named NPF1-NPF8. NPF5 includes Arabidopsis thaliana PTR3 (AtPTR3, now named AtNPF5.2), which is a wound-induced peptide transporter that is necessary for defense against virulent bacterial pathogens. NPF5 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340975 [Multi-domain] Cd Length: 452 Bit Score: 74.23 E-value: 4.98e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502863295 27 EMWERFSFYGIRPLLILFMAATVydgGMGLARenASAIVGIFAGTMYLAALPGGWLADNWLGQQRAVWYGSILIALGHLS 106
Cdd:cd17417 11 EVAERFAYYGIASNLVTYLTTPL---HQSTAR--AAKNVNNWSGTATLLPLLGAFVADAYLGRYRTILISSLIYLLGLVL 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502863295 107 IALSA------------------VMGNNLFFIGLMFIVLGSGLFKTCISVMVGTLYKKGDA----RRDGGFSLFYMGINM 164
Cdd:cd17417 86 LTLSAslpslkppecngtcskasTLQVAFFFFSLYLVAIGQGGHKPCVQAFGADQFDEDDPkekkQKSSFFNWWYFSICA 165
|
170 180 190
....*....|....*....|....*....|....*.
gi 502863295 165 GSFIAPLISGWLIKTHGWHWGFGIGGIGMLVALIIF 200
Cdd:cd17417 166 GSLTAVTVLVYIQDNVGWALGFGIPTIVMALALFVF 201
|
|
| MFS_MdtH_MDR_like |
cd17329 |
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ... |
23-494 |
6.91e-12 |
|
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340887 [Multi-domain] Cd Length: 376 Bit Score: 66.87 E-value: 6.91e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502863295 23 LFFTEMWERFSFYGIRPLLILFMAATvydggMGLARENASAIVGIFAGTMYLAALPGGWLADNWlGQQRAVWYGSILIAL 102
Cdd:cd17329 4 LLIGSFLNRLGFFMVWPFMAIYLHQQ-----LGLSASIVGLVLALSAVAGIVASLIGGRLADRF-GRKPVMLAGLLLRAL 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502863295 103 GHLSIALsaVMGNNLFFIGLMFIVLGSGLFKTCISVMVGTLYKKGdaRRDGGFSLFYMGINMGSFIAPLISGWLIkTHGW 182
Cdd:cd17329 78 GFALLGF--AHSPWLFAIALVLTGFGGGLFEPASEAMIADVTTPE--NRTRAFSLLYWAINLGVAIGPLLGGLLL-LYSF 152
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502863295 183 HWGFGIGGIGMLVALIIFRVFAVPSMKRYDSEVGLDSTWNSPVVKRNGvgawllalavgvavlvtliaqgvivinpvava 262
Cdd:cd17329 153 RLLFLAAAVLFLLAALVLLFLLPETRPKRRAAEKTEILRGYKIVLRDR-------------------------------- 200
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502863295 263 sMLVYVIAASVALYFIYLFIFAGLTRkerarllvcfillvsaaffwsafeqkptsfnlfandYTNRMIGDFEIPAVWFQS 342
Cdd:cd17329 201 -AFLLFLLASFLISLIYFQLESTLPV------------------------------------YVVEILGLGESLLGLLLA 243
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502863295 343 INALFIILLAPVFSwawpKLATmniRPSSITKFVIGILCAAAGFGLMMLAAqnvlsnggagvSPFWLVGSILMLTLGELC 422
Cdd:cd17329 244 LNALLIVLLQFPVA----RLVE---RFRLRKILMIGILLFAIGFAVLAFAN-----------TLAVLILAMIVLTLGEML 305
|
410 420 430 440 450 460 470
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 502863295 423 LSPIGLATMTLLAPERMRGQMMGLWFCASALGNLAAGLIGGHVKADQLDMLPDLFarCSIALLICAAVLIVL 494
Cdd:cd17329 306 VFPAVQTLVAALAPPDKRGSYMGFYALAWGLGRAIGPLVGGLLLDLLGPGLPWLI--LAALGLIAAALLLGL 375
|
|
| MFS_NPF6 |
cd17413 |
NRT1/PTR family (NPF), subfamily 6 of the Major Facilitator Superfamily of transporters; The ... |
23-200 |
2.75e-11 |
|
NRT1/PTR family (NPF), subfamily 6 of the Major Facilitator Superfamily of transporters; The plant Nitrate transporter 1/Peptide transporter (NRT1/PTR) family (NPF) is related to the POT (proton-coupled oligopeptide transporter), Peptide transporter (PepT/PTR), or Solute Carrier 15 (SLC15) family in animals. In contrast to related animal and bacterial counterparts, the plant proteins transport a wide variety of substrates including nitrate, peptides, amino acids, dicarboxylates, glucosinolates, as well as the plant hormones indole-3-acetic acid (IAA) and abscisic acid (ABA). A recent study identified eight subfamilies within this family, named NPF1-NPF8. NPF6 includes the first identified member of the NRT1/PTR family: Arabidopsis thaliana NRT1.1, now called AtNPF6.3. It is a dual affinity nitrate influx transporter and a nitrate sensor. It also transports auxin and has nitrate efflux activity. NPF6 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340971 [Multi-domain] Cd Length: 457 Bit Score: 65.55 E-value: 2.75e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502863295 23 LFFTEMWERFSFYGIRPLLILFMAATvydggMGLARENASAIVGIFAGTMYLAALPGGWLADNWLGQQRAVWYGSILIAL 102
Cdd:cd17413 7 ILGIEMCERLTTLGIGVNLVTYLTGT-----MHLPSATSANIVTNFLGTSFLLCLLGGFIADTFLGRYLTIAIFASIQAL 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502863295 103 GHLSIALSAVMGN----------------------NLFFIGLMFIVLGSGLFKTCISVMVGTLYKKGDARR----DGGFS 156
Cdd:cd17413 82 GVLVLTLSTTLPSlrpppcnhttshhcepasgiqlTVLYLALYLIALGTGGIKSSVSGFGSDQFDENDPKErklmSYFFN 161
|
170 180 190 200
....*....|....*....|....*....|....*....|....
gi 502863295 157 LFYMGINMGSFIAPLISGWLIKTHGWHWGFGIGGIGMLVALIIF 200
Cdd:cd17413 162 RFFFCISVGSLLAVTVLVYIQDNVGRGWGYGICAAAMVLAIVVF 205
|
|
| MFS_SLC15A3_4 |
cd17348 |
Solute Carrier family 15 members 3 and 4 of the Major Facilitator Superfamily of transporters; ... |
21-456 |
3.83e-11 |
|
Solute Carrier family 15 members 3 and 4 of the Major Facilitator Superfamily of transporters; Solute carrier family 15 members 3 (SLC15A3) and 4 (SLC15A4) are members of the proton-coupled oligopeptide transporter (POT) family of integral membrane proteins that mediate the cellular uptake of di/tripeptides and peptide-like drugs. They are peptide/histidine transporters (PHTs) that transport free histidine in addition to di/tripeptides. SLC15A4, also called peptide transporter 4 or peptide/histidine transporter 1 (PHT1), is expressed in the human brain, retina, placenta, and immune cells. It is required for Toll-like receptor 7 (TLR7)- and TLR9-mediated type I interferon production in plasmacytoid dendritic cells (pDCs) and is involved in the pathogenesis of lupus-like autoimmunity. SLC15A3, also called osteoclast transporter, peptide transporter 3, or peptide/histidine transporter 2 (PHT2), is expressed in immune tissues including the spleen and thymus. The SLC15A3/SLC15A4 group belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340906 [Multi-domain] Cd Length: 435 Bit Score: 65.20 E-value: 3.83e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502863295 21 GSLFFTEMWERFSFYGIRPLLILFMAATVYDGGmglaRENASAIVGIFAGTMYLAALPGGWLADNWLGQQRAVWYGSILI 100
Cdd:cd17348 5 AAVLLVELLERAAFYGITSNLVLFLNGSPFNWE----GTQASQALLLFMGATYLLSPFGGWLADAYLGRFWTILLSLLLY 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502863295 101 ALGHLSIALSAvmgNNLFFIGLMFIVLGSGLFKTCISVMVGTLYK-KGDARRDGGFSLFYMGINMGSFIAplisgwlikt 179
Cdd:cd17348 81 LLGMLLFPATA---APALYAGLLLVGLGVGSVKANITPFGADQVKdRGPEATRRFFNWFYWSINLGAILS---------- 147
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502863295 180 hgwhwgfgIGGIGMLVALIIFRV-FAVPsmkrydsevgldstwnspvvkrngvgawllALAVGVAVLVTLIAQGVIVinp 258
Cdd:cd17348 148 --------LGGVAYIQQNVSFLIgYSIP------------------------------AVCVGLAFLVFLCGQPVFI--- 186
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502863295 259 vavasmlvyviaasvalyfiylfifaglTRKERARLLVCFILLVSaafFWSAFEQKPTSF----------NLFANDYTNR 328
Cdd:cd17348 187 ----------------------------DVKALVKILPVFLALIP---YWTVYFQMQTTYvlqslhlkipNIFISNIAGI 235
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502863295 329 MIGDFEIPAVWFQSINALFIILLAPVFSWAW-PKLATMNIRPSSITKFVIG---ILCAAAGFGLMMLAAQNVLSNGG--- 401
Cdd:cd17348 236 TNSSHTFPAAWLTMFDAVLILILIPLKDKLVdPFLKRRGLLPSSLKRIAVGmffVMCSAIAAGILESKRLEIVKHNTtiq 315
|
410 420 430 440 450 460
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 502863295 402 ----------AGVSPFWLVGSILMLTLGELCLSPIGLATMTLLAPERMRGQMMGLWFCASALGNL 456
Cdd:cd17348 316 qqignvtyyaADLPIWWQIPQYLLIGISEIFASIAGLEFAYSAAPKSMQSAIMGLFFFFSGVGSF 380
|
|
| MFS_NPF7 |
cd17419 |
NRT1/PTR family (NPF), subfamily 7 of the Major Facilitator Superfamily of transporters; The ... |
33-200 |
9.29e-11 |
|
NRT1/PTR family (NPF), subfamily 7 of the Major Facilitator Superfamily of transporters; The plant Nitrate transporter/Peptide transporter (NRT1/PTR) family (NPF) is related to the POT (proton-coupled oligopeptide transporter), Peptide transporter (PepT/PTR), or Solute Carrier 15 (SLC15) family in animals. In contrast to related animal and bacterial counterparts, the plant proteins transport a wide variety of substrates including nitrate, peptides, amino acids, dicarboxylates, glucosinolates, as well as the plant hormones indole-3-acetic acid (IAA) and abscisic acid (ABA). A recent study identified eight subfamilies within this family, named NPF1-NPF8. NPF7 includes the nitrate transporters AtNPF7.2 and AtNPF7.3, as well as the dipeptide transporter OsNPF7.3. AtNPF7.3 is a bidirectional transporter involved in nitrate influx and efflux. NPF7 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340977 [Multi-domain] Cd Length: 447 Bit Score: 63.93 E-value: 9.29e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502863295 33 SFYGIRPLLILFMAATvydggMGLARENASAIVGIFAGTMYLAALPGGWLADNWLGQQRAVWYGSILIALGHLSIALSA- 111
Cdd:cd17419 17 AYFGVGVNLVLYLTRV-----MHQSNASAANNVSNWTGTVYITPLIGAFLSDSYWGRYWTSTLFQAIFVIGLLLLTLSSa 91
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502863295 112 --------------------VMGNNLFFIGLMFIVLGSGLFKTCISVMVGTLYKKGD----ARRDGGFSLFYMGINMGSF 167
Cdd:cd17419 92 lpslrppqcgdgdlkcppasAAQTTFLYFSLYLIALGYGGYQPCIATLGADQFDDEDpiekASKSAFFSYFYQALNLGSL 171
|
170 180 190
....*....|....*....|....*....|...
gi 502863295 168 IAPLISGWLIKTHGWHWGFGIGGIGMLVALIIF 200
Cdd:cd17419 172 FSNTILVYFEDNGSWGLGFGISAGAAFIGLVLF 204
|
|
| MFS_NPF4 |
cd17414 |
NRT1/PTR family (NPF), subfamily 4 of the Major Facilitator Superfamily of transporters; The ... |
54-200 |
4.49e-10 |
|
NRT1/PTR family (NPF), subfamily 4 of the Major Facilitator Superfamily of transporters; The plant Nitrate transporter/Peptide transporter (NRT1/PTR) family (NPF) is related to the POT (proton-coupled oligopeptide transporter), Peptide transporter (PepT/PTR), or Solute Carrier 15 (SLC15) family in animals. In contrast to related animal and bacterial counterparts, the plant proteins transport a wide variety of substrates including nitrate, peptides, amino acids, dicarboxylates, glucosinolates, as well as the plant hormones indole-3-acetic acid (IAA) and abscisic acid (ABA). A recent study identified eight subfamilies within this family, named NPF1-NPF8. Members of the NPF4 subfamily have been shown to transport ABA. NPF4 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340972 [Multi-domain] Cd Length: 456 Bit Score: 61.66 E-value: 4.49e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502863295 54 MGLARENASAIVGIFAGTMYLAALPGGWLADNWLGQQRAVWYGSILIALGHLSIALSA--------------------VM 113
Cdd:cd17414 33 MHYSLAKSANIVTNFVGTAFLLALLGGFLSDSFLSSFKTIIIFGSIELLGLILLTVQAhipslqppscnslgdltckePS 112
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502863295 114 GNN--LFFIGLMFIVLGSGLFKTCI----SVMVGTLYKKGDARRDGGFSLFYMGINMGSFIAPLISGWLIKTHGWHWGFG 187
Cdd:cd17414 113 GSQaaILFVGLYLVALGVGCIKPNLpshgADQFDENDPKGRRQLSSFFNWYYFSFSLGALIAVTLVVWVEENKGWDWGFG 192
|
170
....*....|...
gi 502863295 188 IGGIGMLVALIIF 200
Cdd:cd17414 193 VSAAVIAVGILVF 205
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
32-311 |
2.47e-09 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 58.97 E-value: 2.47e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502863295 32 FSFYGIRPLLILFMAATVydggmGLARENASAIVGIFAGTMYLAALPGGWLADNWlGQQRAVWYGSILIALGHLSIALSA 111
Cdd:pfam07690 10 LGRSLLGPALPLLLAEDL-----GISPTEIGLLLTLFSLGYALAQPLAGRLSDRF-GRRRVLLIGLLLFALGLLLLLFAS 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502863295 112 vmGNNLFFIGLMFIVLGSGLFKTCISVMVGTLYKKGdaRRDGGFSLFYMGINMGSFIAPLISGWLIKTHGWHWGFGIGGI 191
Cdd:pfam07690 84 --SLWLLLVLRVLQGLGAGALFPAALALIADWFPPE--ERGRALGLVSAGFGLGAALGPLLGGLLASLFGWRAAFLILAI 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502863295 192 GMLVALIIFRVFAVPSMKRYDS---EVGLDSTWNSPVVKRNGVGAWLLALAVGVAVLVTLIAQGVIVINPVAVASMLVYV 268
Cdd:pfam07690 160 LSLLAAVLLLLPRPPPESKRPKpaeEARLSLIVAWKALLRDPVLWLLLALLLFGFAFFGLLTYLPLYQEVLGLSALLAGL 239
|
250 260 270 280
....*....|....*....|....*....|....*....|....*...
gi 502863295 269 IAASVALYFIYLFIFAG-----LTRKERARLLVCFILLVSAAFFWSAF 311
Cdd:pfam07690 240 LLGLGGLLGAIGRLLLGrlsdrLGRRRRLLLALLLLILAALGLLLLSL 287
|
|
| MFS_NPF3 |
cd17415 |
NRT1/PTR family (NPF), subfamily 3 of the Major Facilitator Superfamily of transporters; The ... |
23-200 |
3.30e-09 |
|
NRT1/PTR family (NPF), subfamily 3 of the Major Facilitator Superfamily of transporters; The plant Nitrate transporter/Peptide transporter (NRT1/PTR) family (NPF) is related to the POT (proton-coupled oligopeptide transporter), Peptide transporter (PepT/PTR), or Solute Carrier 15 (SLC15) family in animals. In contrast to related animal and bacterial counterparts, the plant proteins transport a wide variety of substrates including nitrate, peptides, amino acids, dicarboxylates, glucosinolates, as well as the plant hormones indole-3-acetic acid (IAA) and abscisic acid (ABA). A recent study identified eight subfamilies within this family, named NPF1-NPF8. NPF3 is the smallest NPF subfamily and it includes Cucumis sativus nitrite transporter (CsNitr1), now named CsNPF3.2. It functions as a chloroplast nitrite uptake transporter to remove toxic nitrite from the cytosol. NPF3 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340973 [Multi-domain] Cd Length: 448 Bit Score: 59.00 E-value: 3.30e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502863295 23 LFFTEMWERFSFYGIRPLLILFMAATvydggMGLARENASAIVGIFAGTMYLAALPGGWLADNWLGQQRAVWYGSILIAL 102
Cdd:cd17415 7 IFGNEICERLASVGFHTNLITYLTLQ-----LHMPLVKAANILTNFNGTASLTPLLGAFIADSFAGRFWTITIGSIIYQL 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502863295 103 GHLSIALSAVMGN---------------------NLFFIGLMFIVLGSGLFKTCISVMVGTLYKKGDARRDGG----FSL 157
Cdd:cd17415 82 GMVLLTISAILPSlrpppcnghevcacqassaqlSILYLSLLLTALGSGGIRPCVVAFGADQFDESDPKQAKQtwnfFNW 161
|
170 180 190 200
....*....|....*....|....*....|....*....|...
gi 502863295 158 FYMGINMGSFIAPLISGWLIKTHGWHWGFGIGGIGMLVALIIF 200
Cdd:cd17415 162 YYFCMGIAILLAVTVIVYIQDNVGWGWGFGIPTIAMAISVIAF 204
|
|
| FucP |
COG0738 |
Fucose permease [Carbohydrate transport and metabolism]; |
61-311 |
8.56e-09 |
|
Fucose permease [Carbohydrate transport and metabolism];
Pssm-ID: 440501 [Multi-domain] Cd Length: 391 Bit Score: 57.56 E-value: 8.56e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502863295 61 ASAIVGIFAGTMYLAALPGGWLADnWLGQQRAVWYGSILIALGHLSIALSAVMGnnLFFIGLMFIVLGSGLFKTCISVMV 140
Cdd:COG0738 45 AGLLLFAFFLGYLLASLPAGRLID-RFGYKRGLLLGLLLMALGLLLFALAPSYP--LLLLALFLLGLGLGLLDVAANPYV 121
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502863295 141 GTLYKKGDARRDGGFSLFYMginMGSFIAPLISGWLIKTH---GWHWGFGIGGIGMLVALIIFRVFAVPSMKRYDSE--- 214
Cdd:COG0738 122 AALGPETAASRLNLLHAFFS---LGALLGPLLGGLLILLGlslSWHLPYLILAVLLLLLALLFLRSKLPEIEEEEEEaag 198
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502863295 215 --VGLDSTWNSPVVKRNGVGAWLLALA-VGVAVLVTLIAQGVIVINPVAVASMLVYVIAASVALYFIYLFIfagLTRKER 291
Cdd:COG0738 199 saASLKSLLKNPRLLLGGLAIFLYVGAeGAIGDWLPLYLKDVLGLSEATAALGLSLFWGGMTIGRFLGGFL---LKRFGP 275
|
250 260
....*....|....*....|
gi 502863295 292 ARLLVCFILLVSAAFFWSAF 311
Cdd:COG0738 276 VRLLRLSALLAAVGLLLALL 295
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
19-311 |
1.19e-08 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 56.91 E-value: 1.19e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502863295 19 PLGSLFFTEMWERFSFYGIRPLLILFMAAtvydggMGLARENASAIVGIFAGTMYLAALPGGWLADNWlGQQRAVWYGSI 98
Cdd:COG2814 11 ALLALALGAFLSGLGIGIVLPALPLIAAD------LGASPAQAGLVVTAYLLGAALGAPLAGRLADRF-GRRRVLLLGLL 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502863295 99 LIALGHLSIALSAVMGnnLFFIGLMFIVLGSGLFKTCISVMVGTLYKKGDARRdgGFSLFYMGINMGSFIAPLISGWLIK 178
Cdd:COG2814 84 LFALGSLLCALAPSLW--LLLAARFLQGLGAGALFPAALALIADLVPPERRGR--ALGLLGAGLGLGPALGPLLGGLLAD 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502863295 179 THGWHWGFGIGGIGMLVALIIFRVF--AVPSMKRYDSEVGLDSTWNSPVVKRNGVGAWLLALAV-GVAVLVTLIAQGVIV 255
Cdd:COG2814 160 LFGWRWVFLVNAVLALLALLLLLRLlpESRPAARARLRGSLRELLRRPRLLLLLLLAFLLGFGFfALFTYLPLYLQEVLG 239
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*.
gi 502863295 256 INPVAVASMLVYVIAASVALYFIYLFIFAgltRKERARLLVCFILLVSAAFFWSAF 311
Cdd:COG2814 240 LSASAAGLLLALFGLGGVLGALLAGRLAD---RFGRRRLLLIGLLLLALGLLLLAL 292
|
|
| CynX |
COG2807 |
Cyanate permease [Inorganic ion transport and metabolism]; |
31-305 |
2.98e-08 |
|
Cyanate permease [Inorganic ion transport and metabolism];
Pssm-ID: 442057 [Multi-domain] Cd Length: 399 Bit Score: 55.65 E-value: 2.98e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502863295 31 RFSFYGIRPLLILFMAATvydggmGLARENASAIVGIFAGTMYLAALPGGWLADnWLGQQRAVWYGSILIALGHLsiALS 110
Cdd:COG2807 31 RPAITSVGPLLPEIRADL------GLSATQAGLLTTLPLLAFGLFAPLAPRLAR-RFGLERTLLLALLLLAAGLL--LRS 101
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502863295 111 AVMGNNLFFIGLMFIVLGSGLFKTCISVMVGTLYkkgDARRDGGFSLFYMGINMGSFIAPLISGWLIKTHGWHWGFGIGG 190
Cdd:COG2807 102 LAPSVALLLAGTALIGAGIAVGNVLLPGLIKRWF---PDRVGLMTGLYTAAMGLGAALAAGLTVPLAAALGWRGALAVWA 178
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502863295 191 IGMLVALIIFRVFA---VPSMKRYDSEVGLDSTWNSPVvkrngvgAWLLALAVGVAVLVTLIAQGVIV-------INPVA 260
Cdd:COG2807 179 LLALLALLLWLPLLrrrPAAAAAAPAAASLRSLWRSPL-------AWLLTLFFGLQSLLYYAVVAWLPpilrdagLSAAT 251
|
250 260 270 280
....*....|....*....|....*....|....*....|....*
gi 502863295 261 VASMLVYVIAASVALYFIYLFIfagLTRKERARLLVCFILLVSAA 305
Cdd:COG2807 252 AGLLLSLFQLAGIPGSLLVPLL---ADRLGDRRPLLLLLGLLGLA 293
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
3-204 |
8.09e-08 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 54.50 E-value: 8.09e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502863295 3 SSVNQKESRTFFGHPYPLGSLFFTEMWERFSFYGIRPLLILFMAATvydggMGLARENASAIVGIFAGTMYLAALPGGWL 82
Cdd:cd17325 184 SAARLRSGLRLLLRDRRLLALFLAIFVLAFAFGALEPFLPLYAAEL-----GGLSPAQIGLLFGAQGLASALSQPPAGKL 258
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502863295 83 ADnWLGQQRAVWYGSILIALGHLSIALSAVMGnnLFFIGLMFIVLGSGLFKTCISVMVGTLYKKGdaRRDGGFSLFYMGI 162
Cdd:cd17325 259 SD-RIGRKPLILIGLLLSAVALLLLPLATSFW--LLLLLLALLGLGLGLVFPATLALLADIVPPE--GRGTAMGLFNTAF 333
|
170 180 190 200
....*....|....*....|....*....|....*....|..
gi 502863295 163 NMGSFIAPLISGWLIKTHGWHWGFGIGGIGMLVALIIFRVFA 204
Cdd:cd17325 334 SLGMVLGPLLGGFLYDAFGFATPFLAAAALLLLAAVLFLLLR 375
|
|
| MFS_MJ1317_like |
cd17370 |
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed ... |
44-200 |
9.58e-08 |
|
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed of Methanocaldococcus jannaschii MFS-type transporter MJ1317, Mycobacterium bovis protein Mb2288, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340928 [Multi-domain] Cd Length: 371 Bit Score: 54.09 E-value: 9.58e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502863295 44 FMAATVYDGGMGLARenASAIVGIFAGTMYLAALPGGWLADNWlGQQRAVWYGSILIALGHLSIALSAVMGNNLFFIGLM 123
Cdd:cd17370 221 FLILRAQELGLSAAL--IPLLYALFNLVYALAAYPAGRLSDRI-GRKKLLILGYLSLALAYLGFALGSSLWLLLLGFILW 297
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 502863295 124 FIVLGS--GLFKTCISVMVGtlykkgDARRDGGFSLFYMGINMGSFIAPLISGWLIKTHGWHWGFGIGGIGMLVALIIF 200
Cdd:cd17370 298 GLYMGAqeSIERAAVADLVP------AELRGTAYGLFNTVVGIGWLLASLIAGYLWDLISPSAAFLFSAVLALIALLLL 370
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
53-209 |
5.22e-07 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 51.79 E-value: 5.22e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502863295 53 GMGLARENASAIVGIFAGTMYLAALPGGWLADNWLGQQRAVWYGSILIALghLSIALSAVMGNNLFFIGLMFIV-LGSGL 131
Cdd:COG2271 210 VRGLSLAQAGLLLSLPFLAGIVGSLLGGWLSDRLGRRRKLVLAIGLLLAA--LALLLLALLPSPALAIALLFLAgFGLGG 287
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 502863295 132 FKTCISVMVGTLYkkGDARRDGGFSLFYMGINMGSFIAPLISGWLIKTHGWHWGFGIGGIGMLVALIIFRVFAVPSMK 209
Cdd:COG2271 288 AFGLLWALAAELF--PKKARGTASGLVNTFGFLGGALGPLLVGYLLDATGYQAAFLLLAALALLAALLALLLLRETRK 363
|
|
| MFS_PTR2 |
cd17350 |
Peptide transporter PTR2 of the Major Facilitator Superfamily of transporters; Fungal peptide ... |
17-167 |
1.06e-06 |
|
Peptide transporter PTR2 of the Major Facilitator Superfamily of transporters; Fungal peptide transporter or permease PTR2 is a member of the proton-coupled oligopeptide transporter (POT) family of integral membrane proteins that mediate the cellular uptake of di/tripeptides and peptide-like drugs. It is a 12-transmembrane domain (TMD) integral membrane protein that translocates di-/tripeptides. As with other POT family proteins, it displays characteristic substrate multispecificity. PTR2 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340908 [Multi-domain] Cd Length: 438 Bit Score: 50.93 E-value: 1.06e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502863295 17 PYPLGSLFFTEMWERFSFYGIRPLLILFMAATVYD---GGMGLARENASAIVGIFAGTMYLAALPGGWLADNWLGQQRAV 93
Cdd:cd17350 1 PWSAFLIAIVELCERFSYYGLTGPFQNYMQFGPDDstpGALGLGEQGATGLSNFFTFWCYVTPVIGAYVADQFLGRYNTI 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502863295 94 WYGSILIALGHL-----SI--ALSAVMGNNLFFIGLMFIVLGSGLFKTCISVMVGTLYKKgdaRRDG------------- 153
Cdd:cd17350 81 VCGAVIYFVGILiltctSIpsVIDAGAGLGGFVVAIIIIGLGTGGIKSNVSPLIADQLPK---IKPYvktlkngervivd 157
|
170 180
....*....|....*....|.
gi 502863295 154 -------GFSLFYMGINMGSF 167
Cdd:cd17350 158 pvvtlsrIYMIFYWAINVGSL 178
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
64-308 |
1.32e-06 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 50.65 E-value: 1.32e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502863295 64 IVGIFAGTMYLAALPGGWLADNWlGQQRAVWYGSILIALGHLSIALSAVMGnnLFFIGLMFIVLGSGLFKTCISVMVGTL 143
Cdd:cd17325 36 IVAAYALAQLLFSPPAGRLSDRF-GRKRLLLLGLLLLAVSTLLFAFATSYW--QLLLARFLQGLASAAVWPAAMALIADI 112
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502863295 144 YKKGdaRRDGGFSLFYMGINMGSFIAPLISGWLIKTHGWHWGFGIGGIGMLVALIIFRVFAVPSMKRYDSEVGLDSTWNS 223
Cdd:cd17325 113 APPE--ERGRAMGIFSSAIGLGFLIGPLLGGLLADALGYRAPFLVCAALALLALVLALLLLPEPRPPPNKRAVSAARLRS 190
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502863295 224 PvvkRNGVGAWLLALAVGVAVLVTLIAQGVIVI--------NPVAVASMLVYVIAASVALYFIYLFIFAGLTRKERARLL 295
Cdd:cd17325 191 G---LRLLLRDRRLLALFLAIFVLAFAFGALEPflplyaaeLGGLSPAQIGLLFGAQGLASALSQPPAGKLSDRIGRKPL 267
|
250
....*....|...
gi 502863295 296 VCFILLVSAAFFW 308
Cdd:cd17325 268 ILIGLLLSAVALL 280
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
54-199 |
1.34e-06 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 50.64 E-value: 1.34e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502863295 54 MGLARENASAIVGIFAGTMYLAALPGGWLADNWlGQQRAVWYGSILIALGhlSIALSAVMGNNLFFIGLMFIVLGSGLFK 133
Cdd:COG2271 40 LGLSAAQLGLLASAFFLGYALGQIPAGLLADRF-GRRRVLAIGLLLWGLA--TLLFGFATSFWQLLLLRFLLGLGEAGFF 116
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 502863295 134 TCISVMVGTLYKKgdARRDGGFSLFYMGINMGSFIAPLISGWLIKTHGWHWGFGIGGIGMLVALII 199
Cdd:COG2271 117 PAALKLIAEWFPP--KERGRALGIFNAGGPLGGALAPPLLGWLLAAFGWRAAFLILGLPGLLLALL 180
|
|
| MFS_arabinose_efflux_permease_like |
cd17473 |
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ... |
61-200 |
4.69e-06 |
|
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341026 [Multi-domain] Cd Length: 374 Bit Score: 48.72 E-value: 4.69e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502863295 61 ASAIVGIFAGTMYLAALPGGWLAdNWLGQQRAVWYGSILIALGHLSIALSAvmGNNLFFIGLMFIVLGSGLFKTCISVMV 140
Cdd:cd17473 235 IGLALAIASLAGAIGALLFGRLK-RRLGKRRLLAIGFALMALGFLLLALAS--GLWVVLLGAILAGLGFGLLLPTLNSWA 311
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 502863295 141 GTLYKKgdARRDGGFSLFYMGINMGSFIAPLISGWLIKTHGWHWG-FGIGGIGMLVALIIF 200
Cdd:cd17473 312 MSLVPP--ELRGRAMGIVTSAFFLGQFLSPLVLGPLVNLTGGLSGaFLILGVLALVLAIVL 370
|
|
| MFS_ExuT_GudP_like |
cd17319 |
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ... |
54-203 |
6.29e-06 |
|
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340877 [Multi-domain] Cd Length: 358 Bit Score: 48.34 E-value: 6.29e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502863295 54 MGLARENASAIVGIFAGTMYLAALPGGWLADnWLGQQRavWYGSILIALGHLSiALSAVMGNNLFFIGLMFI--VLGSGL 131
Cdd:cd17319 33 LGLSPTQYGLIASAFFLGYALFQVPGGWLLD-RFGARK--VLAVSMLLWSLFT-ALTGFATSLTSLYVLRFLlgVAEAGF 108
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 502863295 132 FKTCISVMVGTLYKKgdaRRDGGFSLFYMGINMGSFIAPLISGWLIKTHGWHWGFGI-GGIGMLVALIIFRVF 203
Cdd:cd17319 109 FPGAIKALAEWFPAR---ERGRATGLFNSGAPLGAAIGPPLSGWLLLLFGWRWAFIIeGLLGLLLAVLWWFYL 178
|
|
| ProP |
COG0477 |
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ... |
42-310 |
7.57e-06 |
|
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];
Pssm-ID: 440245 [Multi-domain] Cd Length: 295 Bit Score: 47.88 E-value: 7.57e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502863295 42 ILFMAATVYDGGMGLARENASAIVGIFAGTMYLAALPGGWLADnWLGQQRAVWYGSILIALGHLSIALSAVMGnnLFFIG 121
Cdd:COG0477 32 IVNVALPSIAADLGASSAQLGWIVSAYLLGRAIGLLLFGRLGD-RYGRKRVLLIGLLLFGLASLLCGLAPSPE--LLIAA 108
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502863295 122 LMFIVLGSGLFKTCISVMVGTLYKkgDARRDGGFSLFYMGINMGSFIAPLISGWLIKTHGWHWGFGIGGIGMLVALIIFR 201
Cdd:COG0477 109 RALQGIGAGGLMPGALALIAELFP--ARERGRALGLWGAAIGLGLALGPLLGGLLVAALGWRWIFLINAPLGLLALVLRL 186
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502863295 202 VFAVPSMKRYDSEVGLDSTWNSPVVKRNGVGAWLLALAVGVAVLVTLIAQGVIVINPVAVASMLVYVIAASVALYFIYLF 281
Cdd:COG0477 187 RLPESRGLLLALLALALAALLLAALALALLALLLLLLLLLLALLALLLAGAALLLLLALLLLALLLLLALLLLAALLLLL 266
|
250 260
....*....|....*....|....*....
gi 502863295 282 IFAGLTRKERARLLVCFILLVSAAFFWSA 310
Cdd:COG0477 267 LLLLLLALLLALLLLLLLLLLLLLLALLL 295
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
54-204 |
2.71e-05 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 46.41 E-value: 2.71e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502863295 54 MGLARENASAIVGIFAGTMYLAALPGGWLADNWlGQQRAVWYGSILIALGHLSIALsAVMGNNLFFIGLMFIVLGSGLFK 133
Cdd:COG2223 35 FGLSAAQLGLLFAIPVLVGALLRIPLGFLVDRF-GPRRVLLIGLLLLGIGLLLLAL-AVSYWLLLLLGLLLGIGGGGSFA 112
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 502863295 134 TCISvMVGTLYKKgdARRDGGFSLFYMGINMGSFIAPLISGWLIKTHGWHWGFGIGGIGMLVALIIFRVFA 204
Cdd:COG2223 113 VGIA-LVSKWFPP--DRRGLALGLAAGGGNLGAAVAAFLAPLLIAAFGWRNAFLILGILLLVVAVLAWLFL 180
|
|
| MFS_FsR |
cd17478 |
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ... |
61-282 |
3.87e-05 |
|
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341031 [Multi-domain] Cd Length: 365 Bit Score: 46.01 E-value: 3.87e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502863295 61 ASAIVGIFAGTMYLAALPGGWLADNWlGQQRAVWYGSILIALGHLSIALSAVMGnnLFFIGLMFIVLGSGLFKTCISVMV 140
Cdd:cd17478 33 AGLLVSVFSITSSLLQPLFGYLADRK-PRRYLLPLGPLLTGLGLSLLGFAPNYW--LLLLLVALAGIGSAAFHPEGARLA 109
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502863295 141 GTLYKKgdaRRDGGFSLFYMGINMGSFIAPLISGWLIKTHG---WHWGFGIGGIGMLVALIIFRVFAVPSMKRYDSEVGL 217
Cdd:cd17478 110 SQAAGG---RRGLAMSIFSVGGNLGFALGPLIAAALVALFGglgLLILLIIPGLAVALLLLRLRPLKKPEAKKAAAKSSA 186
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 502863295 218 DSTWNSPVVkrngvgawLLALAVGVAVLVTLIAQGVIVINPVAVASMLVYVIAASVALyFIYLFI 282
Cdd:cd17478 187 RSTLKGVWR--------ALLLLLIIVFLRSWVLSSLTTFLPFYLVQRGYSLVFAGLLL-SLFLFA 242
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
42-311 |
1.33e-04 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 44.34 E-value: 1.33e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502863295 42 ILFMAATVYDGGMGLARENASAIVGIFAGTMYLAALPGGWLADNWLgqqRAVWYGSILIALGHLSIALSAVMGNNLFFIG 121
Cdd:cd06174 14 LISPLLPALLQSFGLSASQLGLLFALFSLGYALLQPLAGLLADRFG---RRPVLLLGLLLFALGALLFAFAPSFWLLLLG 90
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502863295 122 LMFIVLGSGLFKTCISVMVGTLYKKgdARRDGGFSLFYMGINMGSFIAPLISGWLI--KTHGWHWGFGIGGIGMLVALI- 198
Cdd:cd06174 91 RFLLGLGSGLIDPAVLALIADLFPE--RERGRALGLLQAFGSVGGILGPLLGGILAssLGFGWRAVFLIAAALALLAAIl 168
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502863295 199 -IFRVFAVPSMKRYDSEVGLDSTWNSPVVKRNGVGAWLLALAVGVAV------LVTLIAQGVIVINPVAVASMLVYVIAA 271
Cdd:cd06174 169 lLLVVPDPPESARAKNEEASSKSVLKLLKRVLKNPGLWLLLLAIFLVnlayysFSTLLPLFLLDLGGLSVAVAGLLLSLF 248
|
250 260 270 280
....*....|....*....|....*....|....*....|
gi 502863295 272 SVALyFIYLFIFAGLTRKERARLLVCFILLVSAAFFWSAF 311
Cdd:cd06174 249 GLAG-ALGSLLLGLLSDRLIGRKPLLLIGLLLMALGLALL 287
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
54-203 |
1.34e-04 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 44.51 E-value: 1.34e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502863295 54 MGLARENASAIVGIFAGTMYLAALPGGWLADnWLGQQRAVWYGSILIALGHLSIALSAVMGNNLFFIGLMFIVLGSGLFK 133
Cdd:COG2211 259 LGLSAALVGLLLALYFLAALLGAPLWPRLAK-RFGKKKAFIIGLLLAALGLLLLFFLGPGNLWLLLVLAALAGIGLGAIL 337
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502863295 134 TCISVMVG-----TLYKKGDARRDGGFSLFYMGINMGSFIAPLISGWLIKTHGWHWG---------------FGIGGIGM 193
Cdd:COG2211 338 VLPWAMLAdvvdyDEWKTGRRREGLYFGIFTFAIKLGQALAGALAGLLLALFGYVAGaaqspsaltgirllfFLLPAVLL 417
|
170
....*....|
gi 502863295 194 LVALIIFRVF 203
Cdd:COG2211 418 LLAALLLLFY 427
|
|
| MFS_NPF1_2 |
cd17416 |
NRT1/PTR family (NPF), subfamily 1 and 2 of the Major Facilitator Superfamily of transporters; ... |
26-200 |
1.69e-04 |
|
NRT1/PTR family (NPF), subfamily 1 and 2 of the Major Facilitator Superfamily of transporters; The plant Nitrate transporter/Peptide transporter (NRT1/PTR) family (NPF) is related to the POT (proton-coupled oligopeptide transporter), Peptide transporter (PepT/PTR), or Solute Carrier 15 (SLC15) family in animals. In contrast to related animal and bacterial counterparts, the plant proteins transport a wide variety of substrates including nitrate, peptides, amino acids, dicarboxylates, glucosinolates, as well as the plant hormones indole-3-acetic acid (IAA) and abscisic acid (ABA). A recent study identified eight subfamilies within this family, named NPF1-NPF8. NPF1 includes Medicago truncatula LATD/NIP, now named MtNPF1.7, which is a high-affinity nitrate transporter and is involved in nodulation and root architecture. NPF2 members are well-established nitrate and glucosinolate transporters, including Arabidopsis nitrate influx and efflux transporters with varied tissue and developmental specificity. Examples are AtNPF2.7, which is expressed in the cortex of mature roots, and AtNPF2.9, which is expressed in root companion cells where it is involved in phloem loading. NPF1/2 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340974 [Multi-domain] Cd Length: 444 Bit Score: 44.18 E-value: 1.69e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502863295 26 TEMWERFSFYGIRPLLILFMAaTVYdgGMGLAreNASAIVGIFAGTMYLAALPGGWLADNWLGQQRAVWYGSILIALGHL 105
Cdd:cd17416 7 NETGEKLASYGLLANLIVYLI-EEY--NMKSI--AAANIINIWSGTTNFLPVVGAFLSDSYFGRFPTISVGSFASLLGMV 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502863295 106 SIALSAVMGN---------------------NLFFIGLMFIVLGSGLFKTCISVMVGTLYKKGDARRDGG----FSLFYM 160
Cdd:cd17416 82 LLTLTAAIPSlrpppcetasslcqspsklqlAVLYSALALLSIGAGGIRPCSLAFGADQFDKKTESGKRGlesfFNWYYF 161
|
170 180 190 200
....*....|....*....|....*....|....*....|
gi 502863295 161 GINMGSFIAPLISGWLIKTHGWHWGFGIGGIGMLVALIIF 200
Cdd:cd17416 162 TFTVAQIISLTAIVYIQDNVSWKIGFGIPAALMLLSFILF 201
|
|
| 2A0115 |
TIGR00895 |
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and ... |
72-203 |
5.25e-04 |
|
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273327 [Multi-domain] Cd Length: 398 Bit Score: 42.34 E-value: 5.25e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502863295 72 MYLAALPGGWLADNwLGQQRAVWYGSILIALGHLSIALSAVMGNNLFFIGLMFIVLGsGLFKTCISVMVGTLYKKgdaRR 151
Cdd:TIGR00895 65 MAFGALFFGPLADR-IGRRRVLLWSILLFSVFTLLCALATNVTQLLILRFLAGLGLG-GLMPNLNALVSEYAPKR---FR 139
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|..
gi 502863295 152 DGGFSLFYMGINMGSFIAPLISGWLIKTHGWHWGFGIGGIGMLVALIIFRVF 203
Cdd:TIGR00895 140 GTAVGLMFCGYPIGAAVGGFLAGWLIPVFGWRSLFYVGGIAPLLLLLLLMRF 191
|
|
| FucP |
COG0738 |
Fucose permease [Carbohydrate transport and metabolism]; |
53-203 |
9.53e-04 |
|
Fucose permease [Carbohydrate transport and metabolism];
Pssm-ID: 440501 [Multi-domain] Cd Length: 391 Bit Score: 41.38 E-value: 9.53e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502863295 53 GMGLARENASAIVGIFAGTMYLAALPGGWLADnWLGQQRAVWYGSILIALGhlsiALSAVMGNNLFFIGLMFIVLG---S 129
Cdd:COG0738 240 VLGLSEATAALGLSLFWGGMTIGRFLGGFLLK-RFGPVRLLRLSALLAAVG----LLLALLAPGPWLALIGLALVGlglS 314
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 502863295 130 GLFKTCISVMVGTLYKKGDARrdggFSLFYMGINMGSFIAPLISGWLIKTHGWHWGFGIGGIGMLVALIIFRVF 203
Cdd:COG0738 315 LMFPTIFSLALDGLGKRTAAA----VSAVLIMGIVGGAIGPPLIGFLADAFGLRAAFLVPLVCYLLILLLALAL 384
|
|
| MFS_NepI_like |
cd17324 |
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ... |
54-200 |
1.86e-03 |
|
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340882 [Multi-domain] Cd Length: 370 Bit Score: 40.61 E-value: 1.86e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502863295 54 MGLARENASAIVGIFAGTMYLAALPGGWLADNWLGQQRAVWYGSILIALghlsiALSAVMGNNLFFIGLMFIVLGSGLFk 133
Cdd:cd17324 229 PGFSSSAIIGLLLLFGVAGVVGSPLAGRLADRGGRRALLIALLLLAAAL-----LLLTLLGPSPLLLLVGLVLWGLGFF- 302
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 502863295 134 TCISVMVGTLYKKGDARRDGGFSLFYMGINMGSFIAPLISGWLIKTHGWHWGFGIGGIGMLVALIIF 200
Cdd:cd17324 303 AAHSALQTRVLRLAPEARGLASSLYLAAYNLGGALGAALGGLVLDHGGWAGVGWVGAALLLLALLLA 369
|
|
| MFS_YfcJ_like |
cd17489 |
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ... |
60-203 |
1.96e-03 |
|
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341042 [Multi-domain] Cd Length: 367 Bit Score: 40.66 E-value: 1.96e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502863295 60 NASAIVGIFAGTMYLAALPGGWLADNWlGQQRAVWYGSILIALGHLsiALSAVMGNNLFFIGLMFIVLGSGLFKTCISVM 139
Cdd:cd17489 228 NAGLFFTVYAIALLLSRPFSGKLSDRK-GPKTVIIPGLLLLALGLL--LLSFAGSPWMLLLAAVLYGLGFGLLFPALQAL 304
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 502863295 140 VGTLYKKgdARRDGGFSLFYMGINMGSFIAPLISGWLIKTHGWHWGFGIGGIGMLVALIIFRVF 203
Cdd:cd17489 305 AVDLVPP--HRRGAANGTFFIFFDLGIGLGGLLLGLVAELFGYRAMFLLAAVVVLLALVLYIFL 366
|
|
| MFS_ExuT_GudP_like |
cd17319 |
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ... |
79-199 |
2.99e-03 |
|
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340877 [Multi-domain] Cd Length: 358 Bit Score: 39.86 E-value: 2.99e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502863295 79 GGWLADnWLGQQRAVWYGSILIALGHLSIALSAVMGNNLFFIGLMFIVL-GSGLFKTCISVMVGTLYKkgDARRDGGFSL 157
Cdd:cd17319 235 GGRLSD-RLLRGARRLVIIIGLLLAAVGLLLAYLTTSPVVAVILLSLAGfGIGAASPVFWSLPADLLP--GEAAATAGGL 311
|
90 100 110 120
....*....|....*....|....*....|....*....|...
gi 502863295 158 FYMGINMGSFIAPLISGWLI-KTHGWHWGFGIGGIGMLVALII 199
Cdd:cd17319 312 INSGGNLGGFVAPLLIGYLVdATGSYTAAFLFLAAVALLAALL 354
|
|
| MFS_Tpo1_MDR_like |
cd17323 |
Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of ... |
151-203 |
3.66e-03 |
|
Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of fungal multidrug resistance (MDR) transporters including several proteins from Saccharomyces cerevisiae such as polyamine transporters 1-4 (Tpo1-4), quinidine resistance proteins 1-3 (Qdr1-3), dityrosine transporter 1 (Dtr1), fluconazole resistance protein 1 (Flr1), and protein HOL1. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, Flr1 confers resistance to the azole derivative fluconazole while Tpo1 confers resistance and adaptation to quinidine and ketoconazole. The polyamine transporters are involved in the detoxification of excess polyamines in the cytoplasm. Tpo1-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340881 [Multi-domain] Cd Length: 376 Bit Score: 39.48 E-value: 3.66e-03
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|...
gi 502863295 151 RDGGFSLFYMGINMGSFIAPLISGWLIKTHGWHWGFGIGGIGMLVALIIFRVF 203
Cdd:cd17323 121 RGKAMGVYSLGPLLGPALGPIIGGFITQSLGWRWIFWFLAIISGFCLILIFLF 173
|
|
| MFS_SLC17 |
cd17318 |
Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily of transporters; The ... |
77-203 |
3.99e-03 |
|
Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily of transporters; The Solute carrier 17 (SLC17) family is primarily involved in the transport of organic anions. There are nime human proteins belonging to this family including: the type I phosphate transporters (SLC17A1-4) that were initially identified as sodium-dependent inorganic phosphate (Pi) transporters but are now known to be involved in tha transport of organic anions; lysosomal acidic sugar transporter (SLC17A5 or sialin), vesicular glutamate transporters (VGluT1#3 or SLC17A7, SLC17A6, and SLC17A8, respectively), and a vesicular nucleotide transporter (VNUT or SLC17A9). SLC17A1 and SLC17A3 have roles in the transport of urate and para-aminohippurate, respectively. The SLC17 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340876 [Multi-domain] Cd Length: 389 Bit Score: 39.52 E-value: 3.99e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502863295 77 LPGGWLADNwLGQQRAVWYGSILIALGHLSIALSAVMGNNLFFIGLMFIVLGSGLFKTCISVMVGtlYKKGDARRDGGFS 156
Cdd:cd17318 74 IPGGYLAEK-YGAKRVLGYSILITALLTLLTPLAARGGYGALIVLRILQGLAQGVTFPAMHALWA--KWAPPLERSRLTS 150
|
90 100 110 120
....*....|....*....|....*....|....*....|....*...
gi 502863295 157 LFYMGINMGSFIAPLISGWLIKTHGWHWGFGI-GGIGMLVALIIFRVF 203
Cdd:cd17318 151 IAYSGSQFGTVIAMPLSGFLCESLGWPSIFYIfGGLGLLWCLLWFFLV 198
|
|
| MFS_spinster_like |
cd17328 |
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; ... |
148-307 |
4.07e-03 |
|
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; The protein spinster family includes Drosophila protein spinster, its vertebrate homologs, and similar proteins. Humans contain three homologs called protein spinster homologs 1 (SPNS1), 2 (SPNS2), and 3 (SPNS3). Protein spinster and its homologs may be sphingolipid transporters that play central roles in endosomes and/or lysosomes storage. SPNS2 is also called sphingosine 1-phosphate (S1P) transporter and is required for migration of myocardial precursors. S1P is a secreted lipid mediator that plays critical roles in cardiovascular, immunological, and neural development and function. The spinster-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340886 [Multi-domain] Cd Length: 405 Bit Score: 39.53 E-value: 4.07e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502863295 148 DARRDGGFSLFYMGINMGSFIAPLISGWLIK-THGWHWGFGI-GGIGMLVALIIFRVFAVPSMKRYDSEVGLDSTWNSpv 225
Cdd:cd17328 118 KEKRTRALGVFYFAIPLGSGLGYVVGGLVAQaTGGWRWAFRVtGVLGVLLAILLLLFVREPPRGAAEGGVMAKSTATS-- 195
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502863295 226 vkrNGVGAWLLAlAVGVAVLVTLIAQGV-IVINPVAVASMLVYVIA--------ASVALYFIYLFIFAGL---------- 286
Cdd:cd17328 196 ---FLADLKALA-KNPSFILSTLGFTAVsFVTGALAFWAPTFFLRAfgvgdlssADVGLIFGAITCIAGVlgvllggila 271
|
170 180
....*....|....*....|....*
gi 502863295 287 ----TRKERARLLVCFILLVSAAFF 307
Cdd:cd17328 272 drlrRKTPRADPLVCAVGLLAAAPF 296
|
|
| MFS_YcxA_like |
cd17355 |
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of ... |
61-309 |
5.68e-03 |
|
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of transporters; This group is composed of uncharacterized bacterial MFS-type transporters including Bacillus subtilis YcxA and YbfB. YcxA has been shown to facilitate the export of surfactin in B. subtilis. The YcxA-like group belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340913 [Multi-domain] Cd Length: 386 Bit Score: 39.18 E-value: 5.68e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502863295 61 ASAIVGIFAGTMYLAALPG---GWLADNWlGQQRAVWYGSILIALGhlsIALSAVMGNNLFFIGLMFIVLGSGLFKTCIS 137
Cdd:cd17355 37 RAVISLAFTVGLLAFGLAQpfvGRLLDRF-GPRRVMLLGLLLLAAG---LVLLALATSLWQLYLLWGLLGGGGAGTLAAV 112
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502863295 138 VMVGTLYKKGDARRDGGFSLFYMGINMGSFIAPLISGWLIKTHGWHWGFGIGGIGML-----VALIIFRVFAVPSMKRYD 212
Cdd:cd17355 113 AFATVAAWWFERRRGLALGILTAGGGLGSLVFLPLGAALIEAFGWRTALLVLALLALlvlvpVLLLLRRRPADLALRAYD 192
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502863295 213 SEVGLDSTWNSPVVKRNGVGAWL-LALAVGVAVLVTLIAQGVIVIN----PVAVASMLVYVIAASVALYFIYLFIFAGLT 287
Cdd:cd17355 193 DASPASPGSTLKEALRSASFWLLaLAFFLCGFAVVGLIVHLVPYLAdrgiSPAAAAVALALIGLFNIVGRLLSGWLGDRY 272
|
250 260
....*....|....*....|..
gi 502863295 288 RKERARLLVCFILLVSAAFFWS 309
Cdd:cd17355 273 SPRRLLAASYALRALGLALLLL 294
|
|
| MFS_MCT_SLC16 |
cd17352 |
Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily of transporters; ... |
61-199 |
5.91e-03 |
|
Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily of transporters; The animal Monocarboxylate transporter (MCT) family is also called Solute carrier family 16 (SLC16 or SLC16A). It is composed of 14 members, MCT1-14. MCTs play an integral role in cellular metabolism via lactate transport and have been implicated in metabolic synergy in tumors. MCT1-4 are proton-coupled transporters that facilitate the transport across the plasma membrane of monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and ketone bodies such as acetoacetate, beta-hydroxybutyrate and acetate. MCT8 and MCT10 are transporters which stimulate the cellular uptake of thyroid hormones such as thyroxine (T4), triiodothyronine (T3), reverse triiodothyronine (rT3) and diidothyronine (T2). MCT10 also functions as a sodium-independent transporter that mediates the uptake or efflux of aromatic acids. Many members are orphan transporters whose substrates are yet to be determined. The MCT family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340910 [Multi-domain] Cd Length: 361 Bit Score: 39.07 E-value: 5.91e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502863295 61 ASAIVGIFAGTMYLAALPGGWLADNwLGQQRAVWYGSILIALGHLSIALSAVMGNNLFFIGLMFiVLGSGLFKTCISVMV 140
Cdd:cd17352 40 IAWIGSLLLGVSLFSGPLSSALVNR-FGCRPVAIAGGLLAALGLLLSSFATSLWQLYLTYGVLG-GLGLGLIYSPAIVIV 117
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*....
gi 502863295 141 GTLYKKgdaRRDGGFSLFYMGINMGSFIAPLISGWLIKTHGWHWGFGIGGIGMLVALII 199
Cdd:cd17352 118 GQYFEK---KRGLATGIAVAGSGVGTFVFPPLLRYLLDNYGWRGALLILGGLCLNLCVC 173
|
|
| MFS_SLC15A5 |
cd17349 |
Solute Carrier family 15 member 5 of the Major Facilitator Superfamily of transporters; Solute ... |
23-198 |
7.33e-03 |
|
Solute Carrier family 15 member 5 of the Major Facilitator Superfamily of transporters; Solute carrier family 15 member 5 (SLC15A5) is a member of the proton-coupled oligopeptide transporter (POT) family of integral membrane proteins that mediate the cellular uptake of di/tripeptides and peptide-like drugs. The specific function of SLC15A5 is unknown. SLC15A5 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340907 [Multi-domain] Cd Length: 437 Bit Score: 38.97 E-value: 7.33e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502863295 23 LFFTEMWERFSFYGIRPLLILFmaATVYDGgmglARENASAIVGI-FAGTMYLAALPGGWLADNWLGQQRAVWYGSILIA 101
Cdd:cd17349 7 LLLVELCERFTFFGIVCNMILF--CTIKLG----YRNHQAAIVNLcFVGTSTLTPVFVGWLAEECMGRNKLVYICLFLHF 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502863295 102 LG-------------------HLSIALSAVMGNNLFFIGLMFIVLGSGLFKTCISVMVG-TLYKKGDARRDGGFSLFYMG 161
Cdd:cd17349 81 LGtallpvvafpfedfyidthHIIHTLAKREQTLLFYVALLTASLGTGGIRAIVCPLSAyGLQDYGSRKLMSFFNWFYWL 160
|
170 180 190
....*....|....*....|....*....|....*..
gi 502863295 162 INMGSFIAPLISGWLIKTHGWHWGFGIGGIGMLVALI 198
Cdd:cd17349 161 VNLNSAVVFVGISYIQQSVAKNLGFLIPFMSVLMALI 197
|
|
| |
