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Conserved domains on  [gi|502876326|ref|WP_013111302|]
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type IV pili methyl-accepting chemotaxis transducer N-terminal domain-containing protein [Planctopirus limnophila]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
COG4191 COG4191
Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal ...
 352-636 4.77e-71

Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal transduction mechanisms];


:

Pssm-ID: 443345 [Multi-domain]  Cd Length: 361  Bit Score: 234.31  E-value: 4.77e-71
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502876326 352 DISDRKLAEDRLKDAHRELEERVALRTGELRDANDELMHQIKERNLAEENSRRLMIQLAHANRVTSLGQLATGIAHEINQ 431
Cdd:COG4191   76 LRLLLLLGLLLLLLLEALLLLLLAALDAEENAELEELERDITELERAEEELRELQEQLVQSEKLAALGELAAGIAHEINN 155

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502876326 432 PLGAIAAYSEALPLVLQNPDQQsDEAARIASRIRDAALRAGSIVNRMRSFLRTSKSEMRLLSINPLIEEVLALCSNELSE 511
Cdd:COG4191  156 PLAAILGNAELLRRRLEDEPDP-EELREALERILEGAERAAEIVRSLRAFSRRDEEEREPVDLNELIDEALELLRPRLKA 234

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502876326 512 QRIEVAKNTsDSEDLCFQGDAVQIQQVLMNLIRNSIQAMSGVSdlPRRLTITSFQEDKKLVLVVEDTGPG---------F 582
Cdd:COG4191  235 RGIEVELDL-PPDLPPVLGDPGQLEQVLLNLLINAIDAMEEGE--GGRITISTRREGDYVVISVRDNGPGippevleriF 311

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 502876326 583 QdnwlttgpfPFHTTKS--DGLGMGLSISQTLIHSHSGELTLENNSSGGARVSFKL 636
Cdd:COG4191  312 E---------PFFTTKPvgKGTGLGLSISYGIVEKHGGRIEVESEPGGGTTFTITL 358
PilJ pfam13675
Type IV pili methyl-accepting chemotaxis transducer N-term; This domain is found on many type ...
 37-141 7.89e-16

Type IV pili methyl-accepting chemotaxis transducer N-term; This domain is found on many type IV pili methyl-accepting chemotaxis transducer proteins where there is also a HAMP signature towards the C-terminus. It is a monomodular four-helix bundle and recognizes nitrate and nitrite (Matilla et al. FEMS Microbiology Reviews, fuab043, 45, 2021, 1. https://doi.org/10.1093/femsre/fuab043).


:

Pssm-ID: 433397 [Multi-domain]  Cd Length: 112  Bit Score: 73.66  E-value: 7.89e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502876326   37 LLFRLNGFGPVINLAGRQRMLSQRMTKAALAIDLDPSKAEYWRRELRDSLDRWKTVHTGLLLGDAQLGLPPVRDArILHA 116
Cdd:pfam13675   2 TLWQSEGDAAAINAAGSLRMQSQRLAKSVLLALAGNYDLAEAFADLEESIDQFDRTLAALALGDLARGLFVPAGA-IRAQ 80

                          90       100
                  ....*....|....*....|....*
gi 502876326  117 FAELQPHFQKLSQAGEQAIQSASIP 141
Cdd:pfam13675  81 LEAVQPLWERLRKPAEAVLAQQDTL 105
PAS super family cl43642
PAS domain [Signal transduction mechanisms];
236-363 5.80e-13

PAS domain [Signal transduction mechanisms];


The actual alignment was detected with superfamily member COG2202:

Pssm-ID: 441804 [Multi-domain]  Cd Length: 258  Bit Score: 69.28  E-value: 5.80e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502876326 236 QRMRISETQFRSLIERMHDGLVVLDNDHRIHYVNDRFAQILFRTVDELKGSDIVSLAALPSQAELKMLLLSANVCSSSPC 315
Cdd:COG2202  130 EALRESEERLRLLVENAPDGIFVLDLDGRILYVNPAAEELLGYSPEELLGKSLLDLLHPEDRERLLELLRRLLEGGRESY 209

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*....
gi 502876326 316 EIEWQLP-ASLKCITLTAVGYQELDDHGAKALFLIVTDISDRKLAEDRL 363
Cdd:COG2202  210 ELELRLKdGDGRWVWVEASAVPLRDGGEVIGVLGIVRDITERKRAEEAL 258
 
Name Accession Description Interval E-value
COG4191 COG4191
Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal ...
 352-636 4.77e-71

Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal transduction mechanisms];


Pssm-ID: 443345 [Multi-domain]  Cd Length: 361  Bit Score: 234.31  E-value: 4.77e-71
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502876326 352 DISDRKLAEDRLKDAHRELEERVALRTGELRDANDELMHQIKERNLAEENSRRLMIQLAHANRVTSLGQLATGIAHEINQ 431
Cdd:COG4191   76 LRLLLLLGLLLLLLLEALLLLLLAALDAEENAELEELERDITELERAEEELRELQEQLVQSEKLAALGELAAGIAHEINN 155

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502876326 432 PLGAIAAYSEALPLVLQNPDQQsDEAARIASRIRDAALRAGSIVNRMRSFLRTSKSEMRLLSINPLIEEVLALCSNELSE 511
Cdd:COG4191  156 PLAAILGNAELLRRRLEDEPDP-EELREALERILEGAERAAEIVRSLRAFSRRDEEEREPVDLNELIDEALELLRPRLKA 234

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502876326 512 QRIEVAKNTsDSEDLCFQGDAVQIQQVLMNLIRNSIQAMSGVSdlPRRLTITSFQEDKKLVLVVEDTGPG---------F 582
Cdd:COG4191  235 RGIEVELDL-PPDLPPVLGDPGQLEQVLLNLLINAIDAMEEGE--GGRITISTRREGDYVVISVRDNGPGippevleriF 311

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 502876326 583 QdnwlttgpfPFHTTKS--DGLGMGLSISQTLIHSHSGELTLENNSSGGARVSFKL 636
Cdd:COG4191  312 E---------PFFTTKPvgKGTGLGLSISYGIVEKHGGRIEVESEPGGGTTFTITL 358
HATPase_TmoS-FixL-DctS-like cd16920
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 535-636 1.21e-30

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Rhizobium meliloti FixL, and Rhodobacter capsulatus DctS; includes hybrid sensor histidine kinase similar to Pseudomonas mendocina TmoS; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs), such as Pseudomonas mendocina TmoS HK of the TmoS-TmoT TCS, which controls the expression of the toluene-4-monooxygenase pathway, Rhizobium meliloti FixL HK of the FixL-FixJ TCS, which regulates the expression of the genes related to nitrogen fixation in the root nodule in response to O(2) levels, and Rhodobacter capsulatus DctS of the DctS-DctR TCS, which controls synthesis of the high-affinity C4-dicarboxylate transport system. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and PAS sensor domain(s); many are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.


Pssm-ID: 340397 [Multi-domain]  Cd Length: 104  Bit Score: 115.57  E-value: 1.21e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502876326 535 IQQVLMNLIRNSIQAMSGVSDLPRRLTITSFQEDKKLV-LVVEDTGPGFQDNWLTTGPFPFHTTKSDGLGMGLSISQTLI 613
Cdd:cd16920    1 IQQVLINLVRNGIEAMSEGGCERRELTIRTSPADDRAVtISVKDTGPGIAEEVAGQLFDPFYTTKSEGLGMGLSICRSII 80

                         90       100
                 ....*....|....*....|...
gi 502876326 614 HSHSGELTLENNSSGGARVSFKL 636
Cdd:cd16920   81 EAHGGRLSVESPAGGGATFQFTL 103
PRK11360 PRK11360
two-component system sensor histidine kinase AtoS;
367-636 3.66e-30

two-component system sensor histidine kinase AtoS;


Pssm-ID: 236901 [Multi-domain]  Cd Length: 607  Bit Score: 125.85  E-value: 3.66e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502876326 367 HRELEERVALRTGELRDANDELM------HQIKERnlaeensRRLMIQLAHANRVTSLGQLATGIAHEINQPLGAIAAY- 439
Cdd:PRK11360 340 GRDRTIELSVSTSLLHNTHGEMIgalvifSDLTER-------KRLQRRVARQERLAALGELVAGVAHEIRNPLTAIRGYv 412

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502876326 440 ------------SEALPLVLQNPDqqsdeaariasrirdaalRAGSIVNRMRSFLRTSKSEMRLLSINPLIEEVLALCsn 507
Cdd:PRK11360 413 qiwrqqtsdppsQEYLSVVLREVD------------------RLNKVIDQLLEFSRPRESQWQPVSLNALVEEVLQLF-- 472

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502876326 508 ELSEQRIEVAKNTSDSEDL-CFQGDAVQIQQVLMNLIRNSIQAMSGVSdlprRLTITSFQE-DKKLVLVVEDTGPGFqDN 585
Cdd:PRK11360 473 QTAGVQARVDFETELDNELpPIWADPELLKQVLLNILINAVQAISARG----KIRIRTWQYsDGQVAVSIEDNGCGI-DP 547

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|..
gi 502876326 586 WLTTGPF-PFHTTKSDGLGMGLSISQTLIHSHSGELTLENNSSGGARVSFKL 636
Cdd:PRK11360 548 ELLKKIFdPFFTTKAKGTGLGLALSQRIINAHGGDIEVESEPGVGTTFTLYL 599
HATPase_c smart00387
Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.
 530-636 2.54e-21

Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.


Pssm-ID: 214643 [Multi-domain]  Cd Length: 111  Bit Score: 89.25  E-value: 2.54e-21
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502876326   530 GDAVQIQQVLMNLIRNSIQAMSGVSdlprRLTITSFQEDKKLVLVVEDTGPGFQDNWLTTGPFPFHTTKSD-----GLGM 604
Cdd:smart00387   1 GDPDRLRQVLSNLLDNAIKYTPEGG----RITVTLERDGDHVEITVEDNGPGIPPEDLEKIFEPFFRTDKRsrkigGTGL 76

                           90       100       110
                   ....*....|....*....|....*....|..
gi 502876326   605 GLSISQTLIHSHSGELTLENNSSGGARVSFKL 636
Cdd:smart00387  77 GLSIVKKLVELHGGEISVESEPGGGTTFTITL 108
HATPase_c pfam02518
Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the ...
 530-636 2.13e-16

Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the structurally related ATPase domains of histidine kinase, DNA gyrase B and HSP90.


Pssm-ID: 460579 [Multi-domain]  Cd Length: 109  Bit Score: 75.10  E-value: 2.13e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502876326  530 GDAVQIQQVLMNLIRNSIQAMSGVSDLprRLTITsfqEDKKLVLVVEDTGPGFQDNWLTTGPFPFHTTKSD---GLGMGL 606
Cdd:pfam02518   1 GDELRLRQVLSNLLDNALKHAAKAGEI--TVTLS---EGGELTLTVEDNGIGIPPEDLPRIFEPFSTADKRgggGTGLGL 75

                          90       100       110
                  ....*....|....*....|....*....|
gi 502876326  607 SISQTLIHSHSGELTLENNSSGGARVSFKL 636
Cdd:pfam02518  76 SIVRKLVELLGGTITVESEPGGGTTVTLTL 105
PilJ pfam13675
Type IV pili methyl-accepting chemotaxis transducer N-term; This domain is found on many type ...
 37-141 7.89e-16

Type IV pili methyl-accepting chemotaxis transducer N-term; This domain is found on many type IV pili methyl-accepting chemotaxis transducer proteins where there is also a HAMP signature towards the C-terminus. It is a monomodular four-helix bundle and recognizes nitrate and nitrite (Matilla et al. FEMS Microbiology Reviews, fuab043, 45, 2021, 1. https://doi.org/10.1093/femsre/fuab043).


Pssm-ID: 433397 [Multi-domain]  Cd Length: 112  Bit Score: 73.66  E-value: 7.89e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502876326   37 LLFRLNGFGPVINLAGRQRMLSQRMTKAALAIDLDPSKAEYWRRELRDSLDRWKTVHTGLLLGDAQLGLPPVRDArILHA 116
Cdd:pfam13675   2 TLWQSEGDAAAINAAGSLRMQSQRLAKSVLLALAGNYDLAEAFADLEESIDQFDRTLAALALGDLARGLFVPAGA-IRAQ 80

                          90       100
                  ....*....|....*....|....*
gi 502876326  117 FAELQPHFQKLSQAGEQAIQSASIP 141
Cdd:pfam13675  81 LEAVQPLWERLRKPAEAVLAQQDTL 105
PAS COG2202
PAS domain [Signal transduction mechanisms];
236-363 5.80e-13

PAS domain [Signal transduction mechanisms];


Pssm-ID: 441804 [Multi-domain]  Cd Length: 258  Bit Score: 69.28  E-value: 5.80e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502876326 236 QRMRISETQFRSLIERMHDGLVVLDNDHRIHYVNDRFAQILFRTVDELKGSDIVSLAALPSQAELKMLLLSANVCSSSPC 315
Cdd:COG2202  130 EALRESEERLRLLVENAPDGIFVLDLDGRILYVNPAAEELLGYSPEELLGKSLLDLLHPEDRERLLELLRRLLEGGRESY 209

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*....
gi 502876326 316 EIEWQLP-ASLKCITLTAVGYQELDDHGAKALFLIVTDISDRKLAEDRL 363
Cdd:COG2202  210 ELELRLKdGDGRWVWVEASAVPLRDGGEVIGVLGIVRDITERKRAEEAL 258
PAS smart00091
PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising ...
 244-301 3.28e-07

PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels.


Pssm-ID: 214512  Cd Length: 67  Bit Score: 47.78  E-value: 3.28e-07
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 502876326   244 QFRSLIERMHDGLVVLDNDHRIHYVNDRFAQILFRTVDELKGSDIVSLAALPSQAELK 301
Cdd:smart00091   2 RLRAILESLPDGIFVLDLDGRILYANPAAEELLGYSPEELIGKSLLELIHPEDRERVQ 59
sensory_box TIGR00229
PAS domain S-box; The PAS domain was previously described. This sensory box, or S-box domain ...
 241-363 8.85e-07

PAS domain S-box; The PAS domain was previously described. This sensory box, or S-box domain occupies the central portion of the PAS domain but is more widely distributed. It is often tandemly repeated. Known prosthetic groups bound in the S-box domain include heme in the oxygen sensor FixL, FAD in the redox potential sensor NifL, and a 4-hydroxycinnamyl chromophore in photoactive yellow protein. Proteins containing the domain often contain other regulatory domains such as response regulator or sensor histidine kinase domains. Other S-box proteins include phytochromes and the aryl hydrocarbon receptor nuclear translocator. [Regulatory functions, Small molecule interactions]


Pssm-ID: 272971 [Multi-domain]  Cd Length: 124  Bit Score: 48.44  E-value: 8.85e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502876326  241 SETQFRSLIERMHDGLVVLDNDHRIHYVNDRFAQILFRTVDELKGSDIVSLAALPSQAELKMLLLSANVCSSSPCEIE-W 319
Cdd:TIGR00229   1 SEERYRAIFESSPDAIIVIDLEGNILYVNPAFEEIFGYSAEELIGRNVLELIPEEDREEVRERIERRLEGEPEPVSEErR 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
gi 502876326  320 QLPASLKCITLTAVGyQELDDHGAKALFL-IVTDISDRKLAEDRL 363
Cdd:TIGR00229  81 VRRKDGSEIWVEVSV-SPIRTNGGELGVVgIVRDITERKEAEEAL 124
PAS cd00130
PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising ...
 252-351 7.26e-06

PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in signal transduction.


Pssm-ID: 238075 [Multi-domain]  Cd Length: 103  Bit Score: 44.93  E-value: 7.26e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502876326 252 MHDGLVVLDNDHRIHYVNDRFAQILFRTVDELKGSDIVSLAALPSQAELKMLLLSANVcSSSPCEIEWQLPASLKCITLT 331
Cdd:cd00130    1 LPDGVIVLDLDGRILYANPAAEQLLGYSPEELIGKSLLDLIHPEDREELRERLENLLS-GGEPVTLEVRLRRKDGSVIWV 79

                         90       100
                 ....*....|....*....|
gi 502876326 332 AVGYQELDDHGAKALFLIVT 351
Cdd:cd00130   80 LVSLTPIRDEGGEVIGLLGV 99
PAS_8 pfam13188
PAS domain; PAS domains are involved in many signalling proteins where they are used as a ...
 243-303 1.68e-05

PAS domain; PAS domains are involved in many signalling proteins where they are used as a signal sensor domain. PAS domains appear in archaea, bacteria and eukaryotes. Several PAS-domain proteins are known to detect their signal by way of an associated cofactor. Heme, flavin, and a 4-hydroxycinnamyl chromophore are used in different proteins. This domain recognizes oxygen and CO (Matilla et al., FEMS Microbiology Reviews, fuab043, 45, 2021, 1. https://doi.org/10.1093/femsre/fuab043).


Pssm-ID: 463802 [Multi-domain]  Cd Length: 65  Bit Score: 42.92  E-value: 1.68e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 502876326  243 TQFRSLIERMHDGLVVLDNDHRIHYVNDRFAQILFRTVDELKGSDIVSLAALPSQAELKML 303
Cdd:pfam13188   1 ERLRALFESSPDGILVLDEGGRIIYVNPAALELLGYELLGELLGELLDLLDPLLEDALELL 61
 
Name Accession Description Interval E-value
COG4191 COG4191
Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal ...
 352-636 4.77e-71

Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal transduction mechanisms];


Pssm-ID: 443345 [Multi-domain]  Cd Length: 361  Bit Score: 234.31  E-value: 4.77e-71
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502876326 352 DISDRKLAEDRLKDAHRELEERVALRTGELRDANDELMHQIKERNLAEENSRRLMIQLAHANRVTSLGQLATGIAHEINQ 431
Cdd:COG4191   76 LRLLLLLGLLLLLLLEALLLLLLAALDAEENAELEELERDITELERAEEELRELQEQLVQSEKLAALGELAAGIAHEINN 155

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502876326 432 PLGAIAAYSEALPLVLQNPDQQsDEAARIASRIRDAALRAGSIVNRMRSFLRTSKSEMRLLSINPLIEEVLALCSNELSE 511
Cdd:COG4191  156 PLAAILGNAELLRRRLEDEPDP-EELREALERILEGAERAAEIVRSLRAFSRRDEEEREPVDLNELIDEALELLRPRLKA 234

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502876326 512 QRIEVAKNTsDSEDLCFQGDAVQIQQVLMNLIRNSIQAMSGVSdlPRRLTITSFQEDKKLVLVVEDTGPG---------F 582
Cdd:COG4191  235 RGIEVELDL-PPDLPPVLGDPGQLEQVLLNLLINAIDAMEEGE--GGRITISTRREGDYVVISVRDNGPGippevleriF 311

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 502876326 583 QdnwlttgpfPFHTTKS--DGLGMGLSISQTLIHSHSGELTLENNSSGGARVSFKL 636
Cdd:COG4191  312 E---------PFFTTKPvgKGTGLGLSISYGIVEKHGGRIEVESEPGGGTTFTITL 358
NtrB COG3852
Signal transduction histidine kinase NtrB, nitrogen specific [Signal transduction mechanisms];
237-645 6.89e-56

Signal transduction histidine kinase NtrB, nitrogen specific [Signal transduction mechanisms];


Pssm-ID: 443061 [Multi-domain]  Cd Length: 361  Bit Score: 193.91  E-value: 6.89e-56
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502876326 237 RMRISETQFRSLIERMHDGLVVLDNDHRIHYVNDRFAQILFRTVDELKGSDIVSLaaLPSQAELKMLLLSA--NVCSSSP 314
Cdd:COG3852    1 ALRESEELLRAILDSLPDAVIVLDADGRITYVNPAAERLLGLSAEELLGRPLAEL--FPEDSPLRELLERAlaEGQPVTE 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502876326 315 CEIEWQLPASLKcITLTAVGYQELDDHGAKALFLIVTDISDRKLAEDrlkdahreleervalrtgelrdandelmhqike 394
Cdd:COG3852   79 REVTLRRKDGEE-RPVDVSVSPLRDAEGEGGVLLVLRDITERKRLER--------------------------------- 124

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502876326 395 rnlaeensrrlmiQLAHANRVTSLGQLATGIAHEINQPLGAIAAYSEALPLVLQNPDQQsdEAARIasrIRDAALRAGSI 474
Cdd:COG3852  125 -------------ELRRAEKLAAVGELAAGLAHEIRNPLTGIRGAAQLLERELPDDELR--EYTQL---IIEEADRLNNL 186

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502876326 475 VNRMRSFLRTSKSEMRLLSINPLIEEVLALCSNELsEQRIEVAKNTsDSEDLCFQGDAVQIQQVLMNLIRNSIQAMSGVS 554
Cdd:COG3852  187 VDRLLSFSRPRPPEREPVNLHEVLERVLELLRAEA-PKNIRIVRDY-DPSLPEVLGDPDQLIQVLLNLVRNAAEAMPEGG 264

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502876326 555 DL------PRRLTITSFQEDKKLVLVVEDTGPG---------FqdnwlttgpFPFHTTKSDGLGMGLSISQTLIHSHSGE 619
Cdd:COG3852  265 TItirtrvERQVTLGGLRPRLYVRIEVIDNGPGipeeildriF---------EPFFTTKEKGTGLGLAIVQKIVEQHGGT 335

                        410       420
                 ....*....|....*....|....*.
gi 502876326 620 LTLENNSSGGARVSFKLAVIHDNSPS 645
Cdd:COG3852  336 IEVESEPGKGTTFRIYLPLEQAEEEP 361
NtrY COG5000
Signal transduction histidine kinase NtrY involved in nitrogen fixation and metabolism ...
 231-642 4.92e-54

Signal transduction histidine kinase NtrY involved in nitrogen fixation and metabolism regulation [Signal transduction mechanisms];


Pssm-ID: 444024 [Multi-domain]  Cd Length: 422  Bit Score: 190.56  E-value: 4.92e-54
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502876326 231 IRSQWQRMRISETQFRSLIERMHDGLVVLDNDHRIHYVNDRFAQILFRTVDELKGSDIVSLAALPSQAELKMLLLSANVC 310
Cdd:COG5000   78 LKEQREELEERRRYLETILENLPAGVIVLDADGRITLANPAAERLLGIPLEELIGKPLEELLPELDLAELLREALERGWQ 157

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502876326 311 SSSPCEIEWQLPASLKCITLTAVGYqelddhgakalFLIVTDISDrklaedrlkdahreleervalrtgelrdandelmh 390
Cdd:COG5000  158 EEIELTRDGRRTLLVRASPLRDDGY-----------VIVFDDITE----------------------------------- 191

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502876326 391 qikernlaeensrrlmiqLAHANRVTSLGQLATGIAHEINQPLGAIAAYSEAL-PLVLQNPDQQSDEAARIASRIRDAAL 469
Cdd:COG5000  192 ------------------LLRAERLAAWGELARRIAHEIKNPLTPIQLSAERLrRKLADKLEEDREDLERALDTIIRQVD 253

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502876326 470 RAGSIVNRMRSFLRTSKSEMRLLSINPLIEEVLALCSNELSEQRIEVaKNTSDSEDLCFQGDAVQIQQVLMNLIRNSIQA 549
Cdd:COG5000  254 RLKRIVDEFLDFARLPEPQLEPVDLNELLREVLALYEPALKEKDIRL-ELDLDPDLPEVLADRDQLEQVLINLLKNAIEA 332

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502876326 550 MSGVSdlprRLTITSFQEDKKLVLVVEDTGPGFQDNWLTTgPF-PFHTTKSDGLGMGLSISQTLIHSHSGELTLENNSSG 628
Cdd:COG5000  333 IEEGG----EIEVSTRREDGRVRIEVSDNGPGIPEEVLER-IFePFFTTKPKGTGLGLAIVKKIVEEHGGTIELESRPGG 407

                        410
                 ....*....|....
gi 502876326 629 GARVSFKLAVIHDN 642
Cdd:COG5000  408 GTTFTIRLPLAEEA 421
KinA COG5805
Sporulation sensor histidine kinase A (Stage II sporulation protein SpoIIF/SpoIIJ) [Cell cycle ...
 166-636 1.09e-38

Sporulation sensor histidine kinase A (Stage II sporulation protein SpoIIF/SpoIIJ) [Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];


Pssm-ID: 444507 [Multi-domain]  Cd Length: 496  Bit Score: 149.50  E-value: 1.09e-38
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502876326 166 QRVAIQLLAAEPGY--LEQMERVVDLFQIVAIEQVSWLRGLSLALMLGAL-----SAMVALswLVLKPANELIRSQWQrM 238
Cdd:COG5805   76 GKTIFDFLEKEYHYrvKTRIERLQKGYDVVMIEQIYCKDGELIYVEVKLFpiynqNGQAAI--LALRDITKKKKIEEI-L 152

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502876326 239 RISETQFRSLIERMHDGLVVLDNDHRIHYVNDRFAQILFRTVDELKGSDIVSLAALPSQAELKMLLLS-ANVCSSSPCEI 317
Cdd:COG5805  153 QEQEERLQTLIENSPDLICVIDTDGRILFINESIERLFGAPREELIGKNLLELLHPCDKEEFKERIESiTEVWQEFIIER 232

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502876326 318 EWqLPASLKCITLTAVGYQELDDHGA-KALFLIVTDISDRKLAEdrlkdahreleervalrtgelrdandELMHQikern 396
Cdd:COG5805  233 EI-ITKDGRIRYFEAVIVPLIDTDGSvKGILVILRDITEKKEAE--------------------------ELMAR----- 280

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502876326 397 laeenSRRLMIqlahanrvtsLGQLATGIAHEINQPLGAIAAYseaLPLVLQNPDQQsDEAARIasrIRDAALRAGSIVN 476
Cdd:COG5805  281 -----SEKLSI----------AGQLAAGIAHEIRNPLTSIKGF---LQLLQPGIEDK-EEYFDI---MLSELDRIESIIS 338

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502876326 477 RMRSFLRTSKSEMRLLSINPLIEEVLALCSNELSEQRIEVAKNTSDsEDLCFQGDAVQIQQVLMNLIRNSIQAM-SGvsd 555
Cdd:COG5805  339 EFLALAKPQAVNKEKENINELIQDVVTLLETEAILHNIQIRLELLD-EDPFIYCDENQIKQVFINLIKNAIEAMpNG--- 414

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502876326 556 lpRRLTITSFQEDKKLVLVVEDTGPGFQDNWLTTGPFPFHTTKSDGLGMGLSISQTLIHSHSGELTLENNSSGGARVSFK 635
Cdd:COG5805  415 --GTITIHTEEEDNSVIIRVIDEGIGIPEERLKKLGEPFFTTKEKGTGLGLMVSYKIIENHNGTIDIDSKVGKGTTFTIT 492


                 .
gi 502876326 636 L 636
Cdd:COG5805  493 L 493
BaeS COG0642
Signal transduction histidine kinase [Signal transduction mechanisms];
328-636 1.19e-35

Signal transduction histidine kinase [Signal transduction mechanisms];


Pssm-ID: 440407 [Multi-domain]  Cd Length: 328  Bit Score: 136.96  E-value: 1.19e-35
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502876326 328 ITLTAVGYQELDDHGAKALFLIVTDISDRKLAEDRLKDAHRELEERVALRTGELRDANDELMHQIKERNLAEENSRRLMI 407
Cdd:COG0642   22 LLLLLLLLLLLALLLLLALLLLLLLLLLLLLLLALALLALLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLALLL 101

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502876326 408 QLAHANRvtSLGQLATGIAHEINQPLGAIAAYSEALPlvlqnpDQQSDEAARIASRIRDAALRAGSIVNRMRSFLRTSKS 487
Cdd:COG0642  102 LLEEANE--AKSRFLANVSHELRTPLTAIRGYLELLL------EELDEEQREYLETILRSADRLLRLINDLLDLSRLEAG 173

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502876326 488 EMRL----LSINPLIEEVLALCSNELSEQRIEVaKNTSDSEDLCFQGDAVQIQQVLMNLIRNSIQAMSGvsdlPRRLTIT 563
Cdd:COG0642  174 KLELepepVDLAELLEEVVELFRPLAEEKGIEL-ELDLPDDLPTVRGDPDRLRQVLLNLLSNAIKYTPE----GGTVTVS 248

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502876326 564 SFQEDKKLVLVVEDTGPG---------FQdnwlttgpfPFHTTKSD----GLGMGLSISQTLIHSHSGELTLENNSSGGA 630
Cdd:COG0642  249 VRREGDRVRISVEDTGPGippedleriFE---------PFFRTDPSrrggGTGLGLAIVKRIVELHGGTIEVESEPGKGT 319


                 ....*.
gi 502876326 631 RVSFKL 636
Cdd:COG0642  320 TFTVTL 325
KinE COG5809
Sporulation sensor histidine kinase E [Cell cycle control, cell division, chromosome ...
 236-636 1.64e-35

Sporulation sensor histidine kinase E [Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];


Pssm-ID: 444511 [Multi-domain]  Cd Length: 489  Bit Score: 140.11  E-value: 1.64e-35
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502876326 236 QRMRISETQFRSLIERMHDGLVVLDNDHRIHYVNDRFAQILFRTVDELKGSDIVSLAALPSQAELKMLLLSANVCSSSPC 315
Cdd:COG5809    8 LQLRKSEQRFRSLFENAPDAILILDLEGKILKVNPAAERIFGYTEDELLGTNILDFLHPDDEKELREILKLLKEGESRDE 87

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502876326 316 EIEWQLPASLKCITLTAVGYQELDDHGAK-ALFLIVTDISDRKlaedRLKDAHRELEERVAL-------------RTGEL 381
Cdd:COG5809   88 LEFELRHKNGKRLEFSSKLSPIFDQNGDIeGMLAISRDITERK----RMEEALRESEEKFRLifnhspdgiivtdLDGRI 163

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502876326 382 RDAND-------------------ELMHQIKERNLAEENS---------------------------------------- 402
Cdd:COG5809  164 IYANPaackllgisieeligksilELIHSDDQENVAAFISqllkdggiaqgevrfwtkdgrwrlleasgapikkngevdg 243

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502876326 403 -----------RRLMIQLAHANRVTSLGQLATGIAHEINQPLGAIAAYseaLPLVLQNPDQQSDEAARIasrIRDAALRA 471
Cdd:COG5809  244 iviifrditerKKLEELLRKSEKLSVVGELAAGIAHEIRNPLTSLKGF---IQLLKDTIDEEQKTYLDI---MLSELDRI 317

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502876326 472 GSIVNRMRSFLRTSKSEMRLLSINPLIEEVLALCSNELSEQRIEVAKNTSDSEDLcFQGDAVQIQQVLMNLIRNSIQAM- 550
Cdd:COG5809  318 ESIISEFLVLAKPQAIKYEPKDLNTLIEEVIPLLQPQALLKNVQIELELEDDIPD-ILGDENQLKQVFINLLKNAIEAMp 396

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502876326 551 SGVSdlprrLTI-TSFQEDKKLVLVVEDTGPGFQDNWLTTGPFPFHTTKSDGLGMGLSISQTLIHSHSGELTLENNSSGG 629
Cdd:COG5809  397 EGGN-----ITIeTKAEDDDKVVISVTDEGCGIPEERLKKLGEPFYTTKEKGTGLGLMVSYKIIEEHGGKITVESEVGKG 471


                 ....*..
gi 502876326 630 ARVSFKL 636
Cdd:COG5809  472 TTFSITL 478
COG4192 COG4192
Signal transduction histidine kinase regulating phosphoglycerate transport system [Signal ...
 369-636 2.08e-33

Signal transduction histidine kinase regulating phosphoglycerate transport system [Signal transduction mechanisms];


Pssm-ID: 443346 [Multi-domain]  Cd Length: 640  Bit Score: 135.97  E-value: 2.08e-33
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502876326 369 ELEERVALRTGELRDANDELMHQIKERNLAEENSRRLMIQLAHANRVTSLGQLATGIAHEINQPLGAIAAYSEALPLVLQ 448
Cdd:COG4192  384 RIARLLRVFRDQAIEKTQELETEIEERKRIEKNLRQTQDELIQAAKMAVVGQTMTSLAHELNQPLNAMSMYLFSAKKALE 463

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502876326 449 npdQQSDEAAR-IASRIRDAALRAGSIVNRMRSFLRTSKSEMRLLSINPLIEEVLALCsnELSEQRIEVAKNTSDseDLC 527
Cdd:COG4192  464 ---QENYAQLPtSLDKIEGLIERMDKIIKSLRQFSRKSDTPLQPVDLRQVIEQAWELV--ESRAKPQQITLHIPD--DLM 536

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502876326 528 FQGDAVQIQQVLMNLIRNSIQAMSGvsdlPRRLTITSFQEDKKLVLVVEDTGPGFQ--DNWLTtgpfPFHTTKSDGLGMG 605
Cdd:COG4192  537 VQGDQVLLEQVLVNLLVNALDAVAT----QPQISVDLLSNAENLRVAISDNGNGWPlvDKLFT----PFTTTKEVGLGLG 608

                        250       260       270
                 ....*....|....*....|....*....|.
gi 502876326 606 LSISQTLIHSHSGELTLENNSSGGARVSFKL 636
Cdd:COG4192  609 LSICRSIMQQFGGDLYLASTLERGAMVILEF 639
KdpD COG2205
K+-sensing histidine kinase KdpD [Signal transduction mechanisms];
403-636 1.06e-32

K+-sensing histidine kinase KdpD [Signal transduction mechanisms];


Pssm-ID: 441807 [Multi-domain]  Cd Length: 239  Bit Score: 126.17  E-value: 1.06e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502876326 403 RRLMIQLAHANRVTSlgQLATGIAHEINQPLGAIAAYSEALplvLQNPDQQSDEAARIASRIRDAALRAGSIVNRMRSFL 482
Cdd:COG2205    3 EEALEELEELERLKS--EFLANVSHELRTPLTSILGAAELL---LDEEDLSPEERRELLEIIRESAERLLRLIEDLLDLS 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502876326 483 RTSKSEMRL----LSINPLIEEVLALCSNELSEQRIEVaKNTSDSEDLCFQGDAVQIQQVLMNLIRNSIQAmsgvSDLPR 558
Cdd:COG2205   78 RLESGKLSLelepVDLAELLEEAVEELRPLAEEKGIRL-ELDLPPELPLVYADPELLEQVLANLLDNAIKY----SPPGG 152

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502876326 559 RLTITSFQEDKKLVLVVEDTGPGFQDNWLTTgPF-PFH----TTKSDGLGMGLSISQTLIHSHSGELTLENNSSGGARVS 633
Cdd:COG2205  153 TITISARREGDGVRISVSDNGPGIPEEELER-IFeRFYrgdnSRGEGGTGLGLAIVKRIVEAHGGTIWVESEPGGGTTFT 231


                 ...
gi 502876326 634 FKL 636
Cdd:COG2205  232 VTL 234
HATPase_TmoS-FixL-DctS-like cd16920
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 535-636 1.21e-30

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Rhizobium meliloti FixL, and Rhodobacter capsulatus DctS; includes hybrid sensor histidine kinase similar to Pseudomonas mendocina TmoS; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs), such as Pseudomonas mendocina TmoS HK of the TmoS-TmoT TCS, which controls the expression of the toluene-4-monooxygenase pathway, Rhizobium meliloti FixL HK of the FixL-FixJ TCS, which regulates the expression of the genes related to nitrogen fixation in the root nodule in response to O(2) levels, and Rhodobacter capsulatus DctS of the DctS-DctR TCS, which controls synthesis of the high-affinity C4-dicarboxylate transport system. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and PAS sensor domain(s); many are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.


Pssm-ID: 340397 [Multi-domain]  Cd Length: 104  Bit Score: 115.57  E-value: 1.21e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502876326 535 IQQVLMNLIRNSIQAMSGVSDLPRRLTITSFQEDKKLV-LVVEDTGPGFQDNWLTTGPFPFHTTKSDGLGMGLSISQTLI 613
Cdd:cd16920    1 IQQVLINLVRNGIEAMSEGGCERRELTIRTSPADDRAVtISVKDTGPGIAEEVAGQLFDPFYTTKSEGLGMGLSICRSII 80

                         90       100
                 ....*....|....*....|...
gi 502876326 614 HSHSGELTLENNSSGGARVSFKL 636
Cdd:cd16920   81 EAHGGRLSVESPAGGGATFQFTL 103
PRK11360 PRK11360
two-component system sensor histidine kinase AtoS;
367-636 3.66e-30

two-component system sensor histidine kinase AtoS;


Pssm-ID: 236901 [Multi-domain]  Cd Length: 607  Bit Score: 125.85  E-value: 3.66e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502876326 367 HRELEERVALRTGELRDANDELM------HQIKERnlaeensRRLMIQLAHANRVTSLGQLATGIAHEINQPLGAIAAY- 439
Cdd:PRK11360 340 GRDRTIELSVSTSLLHNTHGEMIgalvifSDLTER-------KRLQRRVARQERLAALGELVAGVAHEIRNPLTAIRGYv 412

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502876326 440 ------------SEALPLVLQNPDqqsdeaariasrirdaalRAGSIVNRMRSFLRTSKSEMRLLSINPLIEEVLALCsn 507
Cdd:PRK11360 413 qiwrqqtsdppsQEYLSVVLREVD------------------RLNKVIDQLLEFSRPRESQWQPVSLNALVEEVLQLF-- 472

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502876326 508 ELSEQRIEVAKNTSDSEDL-CFQGDAVQIQQVLMNLIRNSIQAMSGVSdlprRLTITSFQE-DKKLVLVVEDTGPGFqDN 585
Cdd:PRK11360 473 QTAGVQARVDFETELDNELpPIWADPELLKQVLLNILINAVQAISARG----KIRIRTWQYsDGQVAVSIEDNGCGI-DP 547

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|..
gi 502876326 586 WLTTGPF-PFHTTKSDGLGMGLSISQTLIHSHSGELTLENNSSGGARVSFKL 636
Cdd:PRK11360 548 ELLKKIFdPFFTTKAKGTGLGLALSQRIINAHGGDIEVESEPGVGTTFTLYL 599
COG4251 COG4251
Bacteriophytochrome (light-regulated signal transduction histidine kinase) [Signal ...
 157-636 1.17e-27

Bacteriophytochrome (light-regulated signal transduction histidine kinase) [Signal transduction mechanisms];


Pssm-ID: 443393 [Multi-domain]  Cd Length: 503  Bit Score: 117.19  E-value: 1.17e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502876326 157 QIPVLTTDDQRVAIQLLAAEPGYLEQMERVVDLFQIVAIEQVSWLRGLSLALMLGALSAMVALSWLVLKPANELIRSQWQ 236
Cdd:COG4251   55 LLSLLALLLLLLLLLLLLLVLAALALLLLLLLLELALVLLALLLVLLLLLALLLLLALLLLLELLLLLLALLLLLLLLAL 134

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502876326 237 RMRISETQFRSLIERMHDGLVVLDNDHRIHYVNDRFAQILFRTVDELKGSDIVSLAALPSQAELKMLLLSANVCSSSPCE 316
Cdd:COG4251  135 LLLEELALLRLALALLLLLLLLLLLLLLLLALILALLLAALAELELLLLLLLVLLLLLLLLLLLLLLLLRLLLELLLLLE 214

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502876326 317 IEWQLPASLKCITLTAVGYQELDDHgakaLFLIVTDISDRKLAEDRLKDAHRELEERVALRTGELRDANDELmhqikern 396
Cdd:COG4251  215 AELLLSLGGGLGLLLLLLLLLVLLL----LLILLLLLLILVLELLELRLELEELEEELEERTAELERSNEEL-------- 282

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502876326 397 laeEnsrrlmiQLAHAnrvtslgqlatgIAHEINQPLGAIAAYSEALplVLQNPDQQSDEAARIASRIRDAALRAGSIVN 476
Cdd:COG4251  283 ---E-------QFAYV------------ASHDLREPLRKISGFSQLL--EEDYGDKLDEEGREYLERIRDAAERMQALID 338

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502876326 477 RMRSFLRTSKSEMRL--LSINPLIEEVLALCSNELSEQRIEVakntsDSEDLC-FQGDAVQIQQVLMNLIRNSIQAMSgv 553
Cdd:COG4251  339 DLLAYSRVGRQELEFepVDLNELLEEVLEDLEPRIEERGAEI-----EVGPLPtVRGDPTLLRQVFQNLISNAIKYSR-- 411

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502876326 554 SDLPRRLTITSFQEDKKLVLVVEDTGPGFQDNWLTT--GPF-PFHT-TKSDGLGMGLSISQTLIHSHSGELTLENNSSGG 629
Cdd:COG4251  412 PGEPPRIEIGAEREGGEWVFSVRDNGIGIDPEYAEKifEIFqRLHSrDEYEGTGIGLAIVKKIVERHGGRIWVESEPGEG 491


                 ....*..
gi 502876326 630 ARVSFKL 636
Cdd:COG4251  492 ATFYFTL 498
WalK COG5002
Sensor histidine kinase WalK [Signal transduction mechanisms];
345-636 7.11e-26

Sensor histidine kinase WalK [Signal transduction mechanisms];


Pssm-ID: 444026 [Multi-domain]  Cd Length: 390  Bit Score: 110.03  E-value: 7.11e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502876326 345 ALFLIVTDISDRKLAEDRLKDAHRELEERVALRTGELRDANDELMHQIKERNLAEENSRRLMIQLAHANRVTSlgQLATG 424
Cdd:COG5002   94 LLLLLLALLILLLLLALLILLAALLLLLSELLLLLLLLGRLSLRLSALLLGLLLLAAVERDITELERLEQMRR--EFVAN 171

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502876326 425 IAHEINQPLGAIAAYSEALplvLQNPDQQSDEAARIASRIRDAALRAGSIVNRMRSFLRTSKSEMRL----LSINPLIEE 500
Cdd:COG5002  172 VSHELRTPLTSIRGYLELL---LDGAADDPEERREYLEIILEEAERLSRLVNDLLDLSRLESGELKLekepVDLAELLEE 248

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502876326 501 VLALCSNELSEQRIEVaKNTSDSEDLCFQGDAVQIQQVLMNLIRNSIQAmsgvSDLPRRLTITSFQEDKKLVLVVEDTGP 580
Cdd:COG5002  249 VVEELRPLAEEKGIEL-ELDLPEDPLLVLGDPDRLEQVLTNLLDNAIKY----TPEGGTITVSLREEDDQVRISVRDTGI 323

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 502876326 581 G---------FQdnwlttgpfPFHTT------KSDGLGMGLSISQTLIHSHSGELTLENNSSGGARVSFKL 636
Cdd:COG5002  324 GipeedlpriFE---------RFYRVdksrsrETGGTGLGLAIVKHIVEAHGGRIWVESEPGKGTTFTITL 385
PRK13837 PRK13837
two-component system VirA-like sensor kinase;
379-649 1.25e-24

two-component system VirA-like sensor kinase;


Pssm-ID: 237526 [Multi-domain]  Cd Length: 828  Bit Score: 109.38  E-value: 1.25e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502876326 379 GELRDANDELMHQIKERNLAEEnSRRLMIQLAHANRVTSLGQLATGIAHEINQPLGAIAAYSEalplVLQNPDQQSDEAA 458
Cdd:PRK13837 412 QLLELALDCLAHAIERRRLETE-RDALERRLEHARRLEAVGTLASGIAHNFNNILGAILGYAE----MALNKLARHSRAA 486

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502876326 459 RIASRIRDAALRAGSIVNRMRSFLRTSKSEMRLLSINPLIEEVLALCSNELSEqRIEVAKNtSDSEDLCFQGDAVQIQQV 538
Cdd:PRK13837 487 RYIDEIISAGARARLIIDQILAFGRKGERNTKPFDLSELVTEIAPLLRVSLPP-GVELDFD-QDQEPAVVEGNPAELQQV 564

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502876326 539 LMNLIRNSIQAMSG---------VSDL--PRRLTITSFQEDKKLVLVVEDTGPGFQDNWLTTGPFPFHTTKSDGLGMGLS 607
Cdd:PRK13837 565 LMNLCSNAAQAMDGagrvdislsRAKLraPKVLSHGVLPPGRYVLLRVSDTGAGIDEAVLPHIFEPFFTTRAGGTGLGLA 644

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|..
gi 502876326 608 ISQTLIHSHSGELTLENNSSGGARVSFKLAVIHDNSPSNVAH 649
Cdd:PRK13837 645 TVHGIVSAHAGYIDVQSTVGRGTRFDVYLPPSSKVPVAPQAF 686
HATPase_c smart00387
Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.
 530-636 2.54e-21

Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.


Pssm-ID: 214643 [Multi-domain]  Cd Length: 111  Bit Score: 89.25  E-value: 2.54e-21
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502876326   530 GDAVQIQQVLMNLIRNSIQAMSGVSdlprRLTITSFQEDKKLVLVVEDTGPGFQDNWLTTGPFPFHTTKSD-----GLGM 604
Cdd:smart00387   1 GDPDRLRQVLSNLLDNAIKYTPEGG----RITVTLERDGDHVEITVEDNGPGIPPEDLEKIFEPFFRTDKRsrkigGTGL 76

                           90       100       110
                   ....*....|....*....|....*....|..
gi 502876326   605 GLSISQTLIHSHSGELTLENNSSGGARVSFKL 636
Cdd:smart00387  77 GLSIVKKLVELHGGEISVESEPGGGTTFTITL 108
HATPase_HupT_MifS-like cd16976
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 535-636 3.05e-21

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Rhodobacter capsulatus HupT and Pseudomonas aeruginosa MifS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Rhodobacter capsulatus HupT of the HupT-HupR two-component regulatory system (TCS), which regulates the synthesis of HupSL, a membrane bound [NiFe]hydrogenase. It also contains the HATPase domain of Pseudomonas aeruginosa MifS, the HK of the MifS-MifR TCS, which may be involved in sensing alpha-ketoglutarate and regulating its transport and subsequent metabolism. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some also have a C-terminal PAS sensor domain.


Pssm-ID: 340435 [Multi-domain]  Cd Length: 102  Bit Score: 89.05  E-value: 3.05e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502876326 535 IQQVLMNLIRNSIQAMSGVSDlpRRLTITSFQEDKKLVLVVEDTGPGFQDNWLTTGPFPFHTTK--SDGLGMGLSISQTL 612
Cdd:cd16976    1 IQQVLMNLLQNALDAMGKVEN--PRIRIAARRLGGRLVLVVRDNGPGIAEEHLSRVFDPFFTTKpvGKGTGLGLSISYGI 78

                         90       100
                 ....*....|....*....|....
gi 502876326 613 IHSHSGELTLENNSSGGARVSFKL 636
Cdd:cd16976   79 VEEHGGRLSVANEEGAGARFTFDL 102
PRK10364 PRK10364
two-component system sensor histidine kinase ZraS;
398-639 8.81e-20

two-component system sensor histidine kinase ZraS;


Pssm-ID: 236674 [Multi-domain]  Cd Length: 457  Bit Score: 92.54  E-value: 8.81e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502876326 398 AEENSRRLMIQLAHANRVTSLGQLATGIAHEINQPLGAIAAYS----EALPlvlqnPDQQSDEAARIASRIRDaalRAGS 473
Cdd:PRK10364 217 YLRSRQLLQDEMKRKEKLVALGHLAAGVAHEIRNPLSSIKGLAkyfaERAP-----AGGEAHQLAQVMAKEAD---RLNR 288

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502876326 474 IVNRMRSFLRTSKSEMRLLSINPLIEEVLALCSNELSEQRIEVAKNTSDSEDLcFQGDAVQIQQVLMNLIRNSIQAMsgv 553
Cdd:PRK10364 289 VVSELLELVKPTHLALQAVDLNDLINHSLQLVSQDANSREIQLRFTANDTLPE-IQADPDRLTQVLLNLYLNAIQAI--- 364

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502876326 554 sdlPR--RLTITSFQEDKKLVLVVEDTGPGFQDNWLTTGPFPFHTTKSDGLGMGLSISQTLIHSHSGELTLENNSSGGAR 631
Cdd:PRK10364 365 ---GQhgVISVTASESGAGVKISVTDSGKGIAADQLEAIFTPYFTTKAEGTGLGLAVVHNIVEQHGGTIQVASQEGKGAT 441


                 ....*...
gi 502876326 632 VSFKLAVI 639
Cdd:PRK10364 442 FTLWLPVN 449
PRK13557 PRK13557
histidine kinase; Provisional
 392-609 2.00e-18

histidine kinase; Provisional


Pssm-ID: 237425 [Multi-domain]  Cd Length: 540  Bit Score: 88.96  E-value: 2.00e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502876326 392 IKERNLAEEnsrrlmiQLAHANRVTSLGQLATGIAHEINQPLGAIAAYSEALPLVLQNPDQQSDEAARIASRIRDAALRA 471
Cdd:PRK13557 144 VSRRRDAED-------ALRQAQKMEALGQLTGGIAHDFNNLLQVMSGYLDVIQAALSHPDADRGRMARSVENIRAAAERA 216

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502876326 472 GSIVNRMRSFLRTSKSEMRLLSINPLIEEVLALCSNELSEqriEVAKNTSDSEDL--CfQGDAVQIQQVLMNLIRNSIQA 549
Cdd:PRK13557 217 ATLTQQLLAFARKQRLEGRVLNLNGLVSGMGELAERTLGD---AVTIETDLAPDLwnC-RIDPTQAEVALLNVLINARDA 292

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 502876326 550 MSGVSDL--------PRRLTITSFQEDKK---LVLVVEDTGPGFQDNWLTTGPFPFHTTKSDGLGMGLSIS 609
Cdd:PRK13557 293 MPEGGRVtirtrnveIEDEDLAMYHGLPPgryVSIAVTDTGSGMPPEILARVMDPFFTTKEEGKGTGLGLS 363
PRK11100 PRK11100
sensory histidine kinase CreC; Provisional
 426-636 1.31e-17

sensory histidine kinase CreC; Provisional


Pssm-ID: 236846 [Multi-domain]  Cd Length: 475  Bit Score: 86.05  E-value: 1.31e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502876326 426 AHEINQPLGAIAAYSEALplvlqNPDQQSDEAARIASRIRDAALRAGSIVNRMrsfLRTSKSEMR-------LLSINPLI 498
Cdd:PRK11100 264 THELKSPLAAIRGAAELL-----QEDPPPEDRARFTGNILTQSARLQQLIDRL---LELARLEQRqelevlePVALAALL 335

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502876326 499 EEVLALCSNELSEQRIEVAKNTSDSEdlcFQGDAVQIQQVLMNLIRNSIQ-AMSGVsdlprRLTITSFQEDKKLVLVVED 577
Cdd:PRK11100 336 EELVEAREAQAAAKGITLRLRPDDAR---VLGDPFLLRQALGNLLDNAIDfSPEGG-----TITLSAEVDGEQVALSVED 407

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 502876326 578 TGPGFQDNWLT-------TGPFPFHTTKSDGLGmgLSISQTLIHSHSGELTLENNSSGGARVSFKL 636
Cdd:PRK11100 408 QGPGIPDYALPriferfySLPRPANGRKSTGLG--LAFVREVARLHGGEVTLRNRPEGGVLATLTL 471
glnL PRK11073
nitrogen regulation protein NR(II);
400-620 2.00e-17

nitrogen regulation protein NR(II);


Pssm-ID: 182947 [Multi-domain]  Cd Length: 348  Bit Score: 83.98  E-value: 2.00e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502876326 400 ENSRRL-MIQLAHANRVTSlGQLATGIAHEINQPLGAIAAYSEALPLVLqnPDQQSDEAARIasrIRDAALRAGSIVNRM 478
Cdd:PRK11073 112 DNQRRLsQEQLQHAQQVAA-RDLVRGLAHEIKNPLGGLRGAAQLLSKAL--PDPALTEYTKV---IIEQADRLRNLVDRL 185

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502876326 479 RSFLRTSKSEMRllSINPLIEEVLALCSNELSEQ-RIEVAKNTSDSEdlcFQGDAVQIQQVLMNLIRNSIQAMSGVSDLP 557
Cdd:PRK11073 186 LGPQRPGTHVTE--SIHKVAERVVQLVSLELPDNvRLIRDYDPSLPE---LAHDPDQIEQVLLNIVRNALQALGPEGGTI 260

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502876326 558 RRLTITSFQ-----EDKKLV--LVVEDTGPGFQDNWLTTGPFPFHTTKSDGLGMGLSISQTLIHSHSGEL 620
Cdd:PRK11073 261 TLRTRTAFQltlhgERYRLAarIDIEDNGPGIPPHLQDTLFYPMVSGREGGTGLGLSIARNLIDQHSGKI 330
HATPase_NtrY-like cd16944
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 531-636 5.97e-17

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Azorhizobium caulinodans NtrY; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs) such as Azorhizobium caulinodans ORS571 NtrY of the NtrY-NtrX TCS, which is involved in nitrogen fixation and metabolism. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and a HAMP sensor domain; some also have PAS sensor domains.


Pssm-ID: 340420 [Multi-domain]  Cd Length: 108  Bit Score: 76.81  E-value: 5.97e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502876326 531 DAVQIQQVLMNLIRNSIQAMSGVSDLPRRLTI-TSFQEDKKLVLVVEDTGPGFQDNWLTTGPFPFHTTKSDGLGMGLSIS 609
Cdd:cd16944    1 DTTQISQVLTNILKNAAEAIEGRPSDVGEVRIrVEADQDGRIVLIVCDNGKGFPREMRHRATEPYVTTRPKGTGLGLAIV 80

                         90       100
                 ....*....|....*....|....*..
gi 502876326 610 QTLIHSHSGELTLENNSSGGARVSFKL 636
Cdd:cd16944   81 KKIMEEHGGRISLSNREAGGACIRIIL 107
HATPase_AtoS-like cd16943
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 534-631 1.89e-16

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli K-12 AtoS; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs) such as Escherichia coli AtoS, an HK of the AtoS-AtoC TCS. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some have accessory domains such as HAMP or PAS sensor domains or CBS-pair domains.


Pssm-ID: 340419 [Multi-domain]  Cd Length: 105  Bit Score: 75.15  E-value: 1.89e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502876326 534 QIQQVLMNLIRNSIQAMSGVSdlprRLTITSFQEDKKLVLVVEDTGPGFQDNWLTTGPFPFHTTK--SDGLGMGLSISQT 611
Cdd:cd16943    3 QLNQVLLNLLVNAAQAMEGRG----RITIRTWAHVDQVLIEVEDTGSGIDPEILGRIFDPFFTTKpvGEGTGLGLSLSYR 78

                         90       100
                 ....*....|....*....|
gi 502876326 612 LIHSHSGELTLENNSSGGAR 631
Cdd:cd16943   79 IIQKHGGTIRVASVPGGGTR 98
HATPase_c pfam02518
Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the ...
 530-636 2.13e-16

Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the structurally related ATPase domains of histidine kinase, DNA gyrase B and HSP90.


Pssm-ID: 460579 [Multi-domain]  Cd Length: 109  Bit Score: 75.10  E-value: 2.13e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502876326  530 GDAVQIQQVLMNLIRNSIQAMSGVSDLprRLTITsfqEDKKLVLVVEDTGPGFQDNWLTTGPFPFHTTKSD---GLGMGL 606
Cdd:pfam02518   1 GDELRLRQVLSNLLDNALKHAAKAGEI--TVTLS---EGGELTLTVEDNGIGIPPEDLPRIFEPFSTADKRgggGTGLGL 75

                          90       100       110
                  ....*....|....*....|....*....|
gi 502876326  607 SISQTLIHSHSGELTLENNSSGGARVSFKL 636
Cdd:pfam02518  76 SIVRKLVELLGGTITVESEPGGGTTVTLTL 105
PilJ pfam13675
Type IV pili methyl-accepting chemotaxis transducer N-term; This domain is found on many type ...
 37-141 7.89e-16

Type IV pili methyl-accepting chemotaxis transducer N-term; This domain is found on many type IV pili methyl-accepting chemotaxis transducer proteins where there is also a HAMP signature towards the C-terminus. It is a monomodular four-helix bundle and recognizes nitrate and nitrite (Matilla et al. FEMS Microbiology Reviews, fuab043, 45, 2021, 1. https://doi.org/10.1093/femsre/fuab043).


Pssm-ID: 433397 [Multi-domain]  Cd Length: 112  Bit Score: 73.66  E-value: 7.89e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502876326   37 LLFRLNGFGPVINLAGRQRMLSQRMTKAALAIDLDPSKAEYWRRELRDSLDRWKTVHTGLLLGDAQLGLPPVRDArILHA 116
Cdd:pfam13675   2 TLWQSEGDAAAINAAGSLRMQSQRLAKSVLLALAGNYDLAEAFADLEESIDQFDRTLAALALGDLARGLFVPAGA-IRAQ 80

                          90       100
                  ....*....|....*....|....*
gi 502876326  117 FAELQPHFQKLSQAGEQAIQSASIP 141
Cdd:pfam13675  81 LEAVQPLWERLRKPAEAVLAQQDTL 105
PRK15347 PRK15347
two component system sensor kinase;
361-644 1.13e-15

two component system sensor kinase;


Pssm-ID: 237951 [Multi-domain]  Cd Length: 921  Bit Score: 80.84  E-value: 1.13e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502876326 361 DRLKDAHRELEERVALRTGELRDAndelmhqikeRNLAEENSRRLMIQLahanrvtslgqlaTGIAHEINQPL-GAIAAY 439
Cdd:PRK15347 364 DTLNEQYDTLENKVAERTQALAEA----------KQRAEQANKRKSEHL-------------TTISHEIRTPLnGVLGAL 420

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502876326 440 SealplVLQNpDQQSDEAARIASRIRDAALRAGSIVNRMRSFLRTSKSEMRL----LSINPLIEEVLALCSNELSEQRIE 515
Cdd:PRK15347 421 E-----LLQN-TPLTAEQMDLADTARQCTLSLLAIINNLLDFSRIESGQMTLsleeTALLPLLDQAMLTIQGPAQSKSLT 494

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502876326 516 VAKNTSDSEDLCFQGDAVQIQQVLMNLIRNSIQAMS--GVsdlprRLTITSfqEDKKLVLVVEDTGPGFQDNWLTTGPFP 593
Cdd:PRK15347 495 LRTFVGAHVPLYLHLDSLRLRQILVNLLGNAVKFTEtgGI-----RLRVKR--HEQQLCFTVEDTGCGIDIQQQQQIFTP 567

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|...
gi 502876326 594 FHTT--KSDGLGMGLSISQTLIHSHSGELTLENNSSGGARVSFKLAVIHDNSP 644
Cdd:PRK15347 568 FYQAdtHSQGTGLGLTIASSLAKMMGGELTLFSTPGVGSCFSLVLPLNEYAPP 620
CitA COG3290
Sensor histidine kinase DipB regulating citrate/malate metabolism [Signal transduction ...
 186-636 3.42e-15

Sensor histidine kinase DipB regulating citrate/malate metabolism [Signal transduction mechanisms];


Pssm-ID: 442519 [Multi-domain]  Cd Length: 389  Bit Score: 77.97  E-value: 3.42e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502876326 186 VVDLFQIVAIEQVSWLRGLSLALMLGALSAMVALSWLVLKPANELIRSQWQRMRISEtQFRSLIERMHDGLVVLDNDHRI 265
Cdd:COG3290   28 ILLLILLLVLLLLLFLLFVIILLLLLLILLLILLLLLLLLLAALLLKLLEEIARLVE-EREAVLESIREGVIAVDRDGRI 106

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502876326 266 HYVNDRFAQILFRTVDELKGSDIVSLAALPSQAELKMLLLSANVCSSspceiewQLPASLKCITLTAVgyqelddhgaka 345
Cdd:COG3290  107 TLINDAARRLLGLDAIGRPIDEVLAEVLETGERDEEILLNGRVLVVN-------RVPIRDDGRVVGAV------------ 167

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502876326 346 lfLIVTDISDRKLAEDRLKDAhRELEErvalrtgELRDANDELMHQIkernlaeeNSRRLMIQLAHanrvtslgqlatgi 425
Cdd:COG3290  168 --ATFRDRTELERLEEELEGV-KELAE-------ALRAQRHDFRNHL--------HTISGLLQLGE-------------- 215

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502876326 426 aheinqplgaiaaYSEALPLVLQNPDQQSDEAARIASRIRDAALRAgsivnrmrsFLRTSKSEMRLLSINPLIEEVLALC 505
Cdd:COG3290  216 -------------YDEALEYIDEISEELQELIDSLLSRIGNPVLAA---------LLLGKAARARERGIDLTIDIDSDLP 273

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502876326 506 SNELseqrievakntsDSEDLCfqgdavqiqQVLMNLIRNSIQAMSGVSDLPRRLTITSFQEDKKLVLVVEDTGPGFQDN 585
Cdd:COG3290  274 DLPL------------SDTDLV---------TILGNLLDNAIEAVEKLPEEERRVELSIRDDGDELVIEVEDSGPGIPEE 332

                        410       420       430       440       450
                 ....*....|....*....|....*....|....*....|....*....|..
gi 502876326 586 WLTTGPFPFHTTK-SDGLGMGLSISQTLIHSHSGELTLENNSSGGARVSFKL 636
Cdd:COG3290  333 LLEKIFERGFSTKlGEGRGLGLALVKQIVEKYGGTIEVESEEGEGTVFTVRL 384
HATPase_SpaK_NisK-like cd16975
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 531-635 2.49e-13

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Bacillus subtilis SpaK and Lactococcus lactis NisK; This family includes histidine kinase-like ATPase (HATPase) domain of two-component sensor histidine kinases similar to Bacillus subtilis SpaK and Lactococcus lactis NisK. SpaK is the histidine kinase (HK) of the SpaK-SpaR two-component regulatory system (TCS), which is involved in the regulation of the biosynthesis of lantibiotic subtilin. NisK is the HK of the NisK-NisR TCS, which is involved in the regulation of the biosynthesis of lantibiotic nisin. SpaK and NisK may function as membrane-associated protein kinases that phosphorylate SpaR and NisR, respectively, in response to environmental signals.


Pssm-ID: 340434 [Multi-domain]  Cd Length: 107  Bit Score: 66.33  E-value: 2.49e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502876326 531 DAVQIQQVLMNLIRNSIQ-AMSGVSdlprrLTITSFQEDKKLVLVVEDTGPGFQDNWLTTGPFPFHT-----TKSDGLGM 604
Cdd:cd16975    1 DTLLLSRALINIISNACQyAPEGGT-----VSISIYDEEEYLYFEIWDNGHGFSEQDLKKALELFYRddtsrRSGGHYGM 75

                         90       100       110
                 ....*....|....*....|....*....|.
gi 502876326 605 GLSISQTLIHSHSGELTLENNSSGGARVSFK 635
Cdd:cd16975   76 GLYIAKNLVEKHGGSLIIENSQKGGAEVTVK 106
PAS COG2202
PAS domain [Signal transduction mechanisms];
236-363 5.80e-13

PAS domain [Signal transduction mechanisms];


Pssm-ID: 441804 [Multi-domain]  Cd Length: 258  Bit Score: 69.28  E-value: 5.80e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502876326 236 QRMRISETQFRSLIERMHDGLVVLDNDHRIHYVNDRFAQILFRTVDELKGSDIVSLAALPSQAELKMLLLSANVCSSSPC 315
Cdd:COG2202  130 EALRESEERLRLLVENAPDGIFVLDLDGRILYVNPAAEELLGYSPEELLGKSLLDLLHPEDRERLLELLRRLLEGGRESY 209

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*....
gi 502876326 316 EIEWQLP-ASLKCITLTAVGYQELDDHGAKALFLIVTDISDRKLAEDRL 363
Cdd:COG2202  210 ELELRLKdGDGRWVWVEASAVPLRDGGEVIGVLGIVRDITERKRAEEAL 258
envZ PRK09467
osmolarity sensor protein; Provisional
 421-637 1.84e-12

osmolarity sensor protein; Provisional


Pssm-ID: 236531 [Multi-domain]  Cd Length: 435  Bit Score: 69.55  E-value: 1.84e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502876326 421 LATGIAHEINQPLGAIAAYSEALPlvlqnpDQQSDEAARIASRIRDAalraGSIVNRMRSFLRT-SKSEMRLLSINPLIE 499
Cdd:PRK09467 232 LMAGVSHDLRTPLTRIRLATEMMS------EEDGYLAESINKDIEEC----NAIIEQFIDYLRTgQEMPMEMADLNALLG 301

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502876326 500 EVLALCSNElsEQRIEVAKNTSDSEdlcFQGDAVQIQQVLMNLIRNSIQAMSGvsdlprRLTITSFQEDKKLVLVVEDTG 579
Cdd:PRK09467 302 EVIAAESGY--EREIETALQPGPIE---VPMNPIAIKRALANLVVNAARYGNG------WIKVSSGTEGKRAWFQVEDDG 370

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 502876326 580 PGFQDNWLTTGPFPFhtTKSD------GLGMGLSISQTLIHSHSGELTLENNSSGG--ARVSFKLA 637
Cdd:PRK09467 371 PGIPPEQLKHLFQPF--TRGDsargssGTGLGLAIVKRIVDQHNGKVELGNSEEGGlsARAWLPLT 434
HATPase_Glnl-NtrB-like cd16918
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 535-618 2.28e-12

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli GlnL (synonyms NtrB and NRII); This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs), similar to Escherichia coli GlnL/NtrB/NRII HK of the two-component regulatory system (TCS) GlnL/GlnG (NtrB-NtrC, or NRII-NRI), which regulates the transcription of genes encoding metabolic enzymes and permeases in response to carbon and nitrogen status in E. coli and related bacteria. Also included in this family are Rhodobacter capsulatus NtrB, Azospirillum brasilense NtrB, Vibrio alginolyticus NtrB, Rhizobium leguminosarum biovar phaseoli NtrB, and Herbaspirillum seropedicae NtrB. Escherichia coli GlnL/NtrB/NRII is both a kinase and a phosphatase, catalyzing the phosphorylation and dephosphorylation of GlnG/NtrC/NRI. The kinase and phosphatase activities of GlnL/NtrB/NRII are regulated by the PII signal transduction protein, which on binding to GlnL/NtrB/NRII, inhibits the kinase activity of GlnL/NtrB/NRII and activates the GlnL/NtrB/NRII phosphatase activity. Proteins having this HATPase domain also have a histidine kinase dimerization and phosphoacceptor domain (HisKA); some also contain PAS sensor domain(s).


Pssm-ID: 340395 [Multi-domain]  Cd Length: 109  Bit Score: 63.96  E-value: 2.28e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502876326 535 IQQVLMNLIRNSIQAMSGVSDLPRRLTITSFQ-----EDKKLVLVVE--DTGPGFQDNWLTTGPFPFHTTKSDGLGMGLS 607
Cdd:cd16918    1 LIQVFLNLVRNAAQALAGSGGEIILRTRTQRQvtlghPRHRLALRVSviDNGPGIPPDLQDTIFYPMVSGRENGTGLGLA 80

                         90
                 ....*....|.
gi 502876326 608 ISQTLIHSHSG 618
Cdd:cd16918   81 IAQNIVSQHGG 91
HATPase_CpxA-like cd16949
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 535-636 9.29e-11

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli CpxA; This family includes the histidine kinase-like ATPase (HATPase) domains of two-component sensor histidine kinase (HKs) similar to Escherichia coli CpxA, HK of the CpxA-CpxR two-component regulatory system (TCS) which may function in acid stress and in cell wall stability. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and a HAMP sensor domain; some also contain a CpxA family periplasmic domain.


Pssm-ID: 340425 [Multi-domain]  Cd Length: 104  Bit Score: 58.88  E-value: 9.29e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502876326 535 IQQVLMNLIRNSIQAMsgvsdlPRRLTITSFQEDKKLVLVVEDTGPGFQDNWLTTGPFPFH------TTKSDGLGMGLSI 608
Cdd:cd16949    1 LARALENVLRNALRYS------PSKILLDISQDGDQWTITITDDGPGVPEDQLEQIFLPFYrvdsarDRESGGTGLGLAI 74

                         90       100
                 ....*....|....*....|....*...
gi 502876326 609 SQTLIHSHSGELTLENNSSGGARVSFKL 636
Cdd:cd16949   75 AERAIEQHGGKIKASNRKPGGLRVRIWL 102
PAS COG2202
PAS domain [Signal transduction mechanisms];
236-374 3.28e-10

PAS domain [Signal transduction mechanisms];


Pssm-ID: 441804 [Multi-domain]  Cd Length: 258  Bit Score: 61.19  E-value: 3.28e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502876326 236 QRMRISETQFRSLIERMHDGLVVLDNDHRIHYVNDRFAQILFRTVDELKGSDIVSLAALPSQAELKMLLLSANVCSSSPC 315
Cdd:COG2202    4 EALEESERRLRALVESSPDAIIITDLDGRILYVNPAFERLTGYSAEELLGKTLRDLLPPEDDDEFLELLRAALAGGGVWR 83

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 502876326 316 EIEWQLPASLKCITLTAVGYQELDDHGAKALFL-IVTDISDRKLAEDRLKDAHRELEERV 374
Cdd:COG2202   84 GELRNRRKDGSLFWVELSISPVRDEDGEITGFVgIARDITERKRAEEALRESEERLRLLV 143
PRK10755 PRK10755
two-component system sensor histidine kinase PmrB;
494-642 4.48e-09

two-component system sensor histidine kinase PmrB;


Pssm-ID: 236751 [Multi-domain]  Cd Length: 356  Bit Score: 58.83  E-value: 4.48e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502876326 494 INPLIEEVLALCsnELSEQRIEVaknTSDSEDLCFQGDAVQIQQVLMNLIRNSiqamSGVSDLPRRLTITSFQEDKKLVL 573
Cdd:PRK10755 212 ILPSQDELSEML--EQRQQTLLL---PESAADITVQGDATLLRLLLRNLVENA----HRYSPEGSTITIKLSQEDGGAVL 282

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 502876326 574 VVEDTGPGFQDNWLT--TGPFPFHTTKSDGLGMGLSISQTLIHSHSGELTLENNSSGG---ARVSFKLAVIHDN 642
Cdd:PRK10755 283 AVEDEGPGIDESKCGelSKAFVRMDSRYGGIGLGLSIVSRITQLHHGQFFLQNRQERSgtrAWVWLPKAQNVAN 356
HATPase_BaeS-like cd16946
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 531-636 7.41e-09

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli BasS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) similar to Escherichia coli BaeS HK of the BaeS/BaeR two-component regulatory system (TCS), which responds to envelope stress. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), and a HAMP sensory domain.


Pssm-ID: 340422 [Multi-domain]  Cd Length: 109  Bit Score: 53.62  E-value: 7.41e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502876326 531 DAVQIQQVLMNLIRNSIQamsgVSDLPRRLTITSFQEDKKLVLVVEDTGPGFQDNWLTTGPFPFHTTKSD------GLGM 604
Cdd:cd16946    1 DRDRLQQLFVNLLENSLR----YTDTGGKLRIRAAQTPQEVRLDVEDSAPGVSDDQLARLFERFYRVESSrnrasgGSGL 76

                         90       100       110
                 ....*....|....*....|....*....|..
gi 502876326 605 GLSISQTLIHSHSGELTLENNSSGGARVSFKL 636
Cdd:cd16946   77 GLAICHNIALAHGGTISAEHSPLGGLRLVLTL 108
PRK11466 PRK11466
hybrid sensory histidine kinase TorS; Provisional
 367-645 9.14e-09

hybrid sensory histidine kinase TorS; Provisional


Pssm-ID: 236914 [Multi-domain]  Cd Length: 914  Bit Score: 58.76  E-value: 9.14e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502876326 367 HRE-LEERVALRTGELRdandELMHQIKERNLAEENsrrlmiqlahANRVTSlgQLATGIAHEINQPLGAIAAYSEALPL 445
Cdd:PRK11466 408 HREqLAAQVKARTAELQ----ELVIEHRQARAEAEK----------ASQAKS--AFLAAMSHEIRTPLYGILGTAQLLAD 471

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502876326 446 VLQNPDQQSDEAAriasrIRDAALRAGSIVNRM--RSFLRTSKSEMRL----LSINPLIEEVLALCSNELSEQRIEVAKN 519
Cdd:PRK11466 472 NPALNAQRDDLRA-----ITDSGESLLTILNDIldYSAIEAGGKNVSVsdepFEPRPLLESTLQLMSGRVKGRPIRLATD 546

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502876326 520 TSDSEDLCFQGDAVQIQQVLMNLIRNSIQAMS-GVsdlprrLTITSFQEDKKLVLVVEDTGPGFQDNWLTT--GPFPFHT 596
Cdd:PRK11466 547 IADDLPTALMGDPRRIRQVITNLLSNALRFTDeGS------IVLRSRTDGEQWLVEVEDSGCGIDPAKLAEifQPFVQVS 620

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*....
gi 502876326 597 TKSDGLGMGLSISQTLIHSHSGELTLENNSSGGARVSFKLAVIHDNSPS 645
Cdd:PRK11466 621 GKRGGTGLGLTISSRLAQAMGGELSATSTPEVGSCFCLRLPLRVATAPV 669
HATPase_EvgS-ArcB-TorS-like cd16922
Histidine kinase-like ATPase domain of two-component sensor histidine kinases, many are hybrid ...
 535-636 4.09e-08

Histidine kinase-like ATPase domain of two-component sensor histidine kinases, many are hybrid sensor histidine kinases, similar to Escherichia coli EvgS, ArcB, TorS, BarA, RcsC; This family contains the histidine kinase-like ATPase (HATPase) domains of various two-component hybrid sensor histidine kinases (HKs), including the following Escherichia coli HKs: EvgS, a HK of the EvgS-EvgA two-component system (TCS) that confers acid resistance; ArcB, a HK of the ArcB-ArcA TCS that modulates the expression of numerous genes in response to respiratory growth conditions; TorS, a HK of the TorS-TorR TCS which is involved in the anaerobic utilization of trimethylamine-N-oxide; BarA, a HK of the BarA-UvrY TCS involved in the regulation of carbon metabolism; and RcsC, a HK of the RcsB-RcsC TCS which regulates the expression of the capsule operon and of the cell division gene ftsZ. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), with most having accessory sensor domain(s) such as GAF, PAS and CHASE; many are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.


Pssm-ID: 340399 [Multi-domain]  Cd Length: 110  Bit Score: 51.72  E-value: 4.09e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502876326 535 IQQVLMNLIRNSIQ--AMSGVSdlprrLTITSFQEDKKLVLV---VEDTGPG---------FQdnwlttgpfPFH----- 595
Cdd:cd16922    1 LRQILLNLLGNAIKftEEGEVT-----LRVSLEEEEEDGVQLrfsVEDTGIGipeeqqarlFE---------PFSqadss 66

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|..
gi 502876326 596 -TTKSDGLGMGLSISQTLIHSHSGELTLENNSSGGARVSFKL 636
Cdd:cd16922   67 tTRKYGGTGLGLAISKKLVELMGGDISVESEPGQGSTFTFTL 108
HATPase_DpiB-CitA-like cd16915
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 538-633 5.03e-08

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli K-12 DpiB, DcuS, and Bacillus subtilis CitS, DctS, and YufL; This family includes histidine kinase-like ATPase domains of Escherichia coli K-12 DpiB and DcuS, and Bacillus subtilis CitS, DctS and MalK histidine kinases (HKs) all of which are two component transduction systems (TCSs). E. coli K-12 DpiB (also known as CitA) is the histidine kinase (HK) of DpiA-DpiB, a two-component signal transduction system (TCS) required for the expression of citrate-specific fermentation genes and genes involved in plasmid inheritance. E. coli K-12 DcuS (also known as YjdH) is the HK of DcuS-DcuR, a TCS that in the presence of the extracellular C4-dicarboxlates, activates the expression of the genes of anaerobic fumarate respiration and of aerobic C4-dicarboxylate uptake. CitS is the HK of Bacillus subtilis CitS-CitT, a TCS which regulates expression of CitM, the Mg-citrate transporter. Bacillus subtilis DctS forms a tripartite sensor unit (DctS/DctA/DctB) for sensing C4 dicarboxylates. Bacillus subtilis MalK (also known as YfuL) is the HK of MalK-MalR (YufL-YufM) a TCS which regulates the expression of the malate transporters MaeN (YufR) and YflS, and is essential for utilization of malate in minimal medium. Proteins having this DpiB-CitA-like HATPase domain generally have sensor domains such as Cache and PAS, and a histidine kinase A (HisKA)-like SpoOB-type, alpha-helical domain.


Pssm-ID: 340392 [Multi-domain]  Cd Length: 104  Bit Score: 51.13  E-value: 5.03e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502876326 538 VLMNLIRNSIQAMSGVSDLPRRLTITSFQEDKKLVLVVEDTGPG---------FQDNWLTTGPfpfhttksDGLGMGLSI 608
Cdd:cd16915    4 IVGNLIDNALDALAATGAPNKQVEVFLRDEGDDLVIEVRDTGPGiapelrdkvFERGVSTKGQ--------GERGIGLAL 75

                         90       100
                 ....*....|....*....|....*
gi 502876326 609 SQTLIHSHSGELTLENNSSGGARVS 633
Cdd:cd16915   76 VRQSVERLGGSITVESEPGGGTTFS 100
HATPase_BvrS-ChvG-like cd16953
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 537-636 1.07e-07

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Brucella abortus BvrS and Sinorhizobium meliloti ChvG; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Brucella abortus BvrS of the BvrR-BvrS two-component regulatory system (TCS), which controls cell invasion and intracellular survival, as well as Sinorhizobium meliloti and Agrobacterium tumefaciens ChvG of the ChvI-ChvG TCS necessary for endosymbiosis and pathogenicity in plants. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), an accessory HAMP sensor domain, a periplasmic stimulus-sensing domain, and some also have a sensor N-terminal transmembrane domain.


Pssm-ID: 340429 [Multi-domain]  Cd Length: 110  Bit Score: 50.65  E-value: 1.07e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502876326 537 QVLMNLIRNsiqAMSGVSDLPRRLTITSFQEDKKLVLVVEDTGPGFQDNWLTTGPFPFHTTKSDGL------GMGLSISQ 610
Cdd:cd16953    3 QVLRNLIGN---AISFSPPDTGRITVSAMPTGKMVTISVEDEGPGIPQEKLESIFDRFYTERPANEafgqhsGLGLSISR 79

                         90       100       110
                 ....*....|....*....|....*....|
gi 502876326 611 TLIHSHSGELTLENNSSG----GARVSFKL 636
Cdd:cd16953   80 QIIEAHGGISVAENHNQPgqviGARFTVQL 109
HisKA cd00082
Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed ...
 417-483 1.36e-07

Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-autophosphorylation by the catalytic domain of the histidine kinase. They subsequently transfer the phosphoryl group to the Asp acceptor residue of a response regulator protein. Two-component signalling systems, consisting of a histidine protein kinase that senses a signal input and a response regulator that mediates the output, are ancient and evolutionarily conserved signaling mechanisms in prokaryotes and eukaryotes.


Pssm-ID: 119399 [Multi-domain]  Cd Length: 65  Bit Score: 48.75  E-value: 1.36e-07
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 502876326 417 SLGQLATGIAHEINQPLGAIAAYSEalplVLQNPDQQSDEAARIASRIRDAALRAGSIVNRMRSFLR 483
Cdd:cd00082    3 AKGEFLANVSHELRTPLTAIRGALE----LLEEELLDDEEQREYLERIREEAERLLRLINDLLDLSR 65
PRK10549 PRK10549
two-component system sensor histidine kinase BaeS;
530-641 1.79e-07

two-component system sensor histidine kinase BaeS;


Pssm-ID: 182539 [Multi-domain]  Cd Length: 466  Bit Score: 53.87  E-value: 1.79e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502876326 530 GDAVQIQQVLMNLIRNSIQamsgVSDLPRRLTITSFQEDKKLVLVVEDTGPGFQDNWLTTGPFPFHTTK------SDGLG 603
Cdd:PRK10549 348 GDPDRLMQLFNNLLENSLR----YTDSGGSLHISAEQRDKTLRLTFADSAPGVSDEQLQKLFERFYRTEgsrnraSGGSG 423

                         90       100       110
                 ....*....|....*....|....*....|....*...
gi 502876326 604 MGLSISQTLIHSHSGELTLENNSSGGARVSFKLAVIHD 641
Cdd:PRK10549 424 LGLAICLNIVEAHNGRIIAAHSPFGGVSITVELPLERD 461
PRK10490 PRK10490
sensor protein KdpD; Provisional
 421-636 1.98e-07

sensor protein KdpD; Provisional


Pssm-ID: 236701 [Multi-domain]  Cd Length: 895  Bit Score: 54.27  E-value: 1.98e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502876326 421 LATGIAHEINQPLGAIAAYSEALPLVLQNpdqQSDEAARIASRIRDAALRAGSIVNRMRSFLRTSKSEMRL----LSINP 496
Cdd:PRK10490 667 LLAALSHDLRTPLTVLFGQAEILTLDLAS---EGSPHARQASEIRQQVLNTTRLVNNLLDMARIQSGGFNLrkewLTLEE 743

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502876326 497 LIEEVLALCSNELSEQRIEVakntSDSEDLCF-QGDAVQIQQVLMNLIRNSIQ-AMSGVsdlprRLTITSFQEDKKLVLV 574
Cdd:PRK10490 744 VVGSALQMLEPGLSGHPINL----SLPEPLTLiHVDGPLFERVLINLLENAVKyAGAQA-----EIGIDAHVEGERLQLD 814

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 502876326 575 VEDTGPGFQDNWLTT--GPFPFHTTKSD--GLGMGLSISQTLIHSHSGELTLENNSSGGARVSFKL 636
Cdd:PRK10490 815 VWDNGPGIPPGQEQLifDKFARGNKESAipGVGLGLAICRAIVEVHGGTIWAENRPEGGACFRVTL 880
PAS smart00091
PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising ...
 244-301 3.28e-07

PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels.


Pssm-ID: 214512  Cd Length: 67  Bit Score: 47.78  E-value: 3.28e-07
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 502876326   244 QFRSLIERMHDGLVVLDNDHRIHYVNDRFAQILFRTVDELKGSDIVSLAALPSQAELK 301
Cdd:smart00091   2 RLRAILESLPDGIFVLDLDGRILYANPAAEELLGYSPEELIGKSLLELIHPEDRERVQ 59
HATPase_FilI-like cd16921
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 535-636 4.26e-07

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Methanosaeta harundinacea FilI and some hybrid sensor histidine kinases; This family includes FilI, the histidine kinase (HK) component of FilI-FilRs, a two-component signal transduction system (TCS) of the methanogenic archaeon, Methanosaeta harundinacea, which is involved in regulating methanogenesis. The cytoplasmic HK core consists of a C-terminal HK-like ATPase domain (represented here) and a histidine kinase dimerization and phosphoacceptor domain (HisKA) domain, which, in FilI, are coupled to CHASE, HAMP, PAS, and GAF sensor domains. FilI-FilRs catalyzes the phosphotransfer between FilI (HK) and FilRs (FilR1 and FilR2, response regulators) of the TCS. TCSs are predicted to be of bacterial origin, and acquired by archaea by horizontal gene transfer. This model also includes related HATPase domains such as that of Synechocystis sp. PCC6803 phytochrome-like protein Cph1. Proteins having this HATPase domain and HisKA domain also have accessory sensor domains such as CHASE, GAF, HAMP and PAS; some are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.


Pssm-ID: 340398 [Multi-domain]  Cd Length: 105  Bit Score: 48.48  E-value: 4.26e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502876326 535 IQQVLMNLIRNSIQAMSgvSDLPRRLTITSFQEDKKLVLVVEDTGPGFQDNWLTT--GPFP-FHT-TKSDGLGMGLSISQ 610
Cdd:cd16921    1 LGQVLTNLLGNAIKFRR--PRRPPRIEVGAEDVGEEWTFYVRDNGIGIDPEYAEKvfGIFQrLHSrEEYEGTGVGLAIVR 78

                         90       100
                 ....*....|....*....|....*.
gi 502876326 611 TLIHSHSGELTLENNSSGGARVSFKL 636
Cdd:cd16921   79 KIIERHGGRIWLESEPGEGTTFYFTL 104
HATPase_RstB-like cd16939
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 535-636 6.24e-07

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Salmonella typhimurium RstB; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Salmonella typhimurium RstB HK of the RstA-RstB two-component regulatory system (TCS), which regulates expression of the constituents participating in pyrimidine metabolism and iron acquisition, and may be required for regulation of Salmonella motility and invasion. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), and a HAMP sensor domain.


Pssm-ID: 340416 [Multi-domain]  Cd Length: 104  Bit Score: 48.20  E-value: 6.24e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502876326 535 IQQVLMNLIRNSIQAMSgvsdlpRRLTITSFQEDKKLVLVVEDTGPGF-QDNWLTT-GPF----PFHTTKSDGLGMGLSI 608
Cdd:cd16939    1 MARALDNLLRNALRYAH------RTVRIALLVSGGRLTLIVEDDGPGIpAAARERVfEPFvrldPSRDRATGGFGLGLAI 74

                         90       100
                 ....*....|....*....|....*...
gi 502876326 609 SQTLIHSHSGELTLENNSSGGARVSFKL 636
Cdd:cd16939   75 VHRVALWHGGHVECDDSELGGACFRLTW 102
sensory_box TIGR00229
PAS domain S-box; The PAS domain was previously described. This sensory box, or S-box domain ...
 241-363 8.85e-07

PAS domain S-box; The PAS domain was previously described. This sensory box, or S-box domain occupies the central portion of the PAS domain but is more widely distributed. It is often tandemly repeated. Known prosthetic groups bound in the S-box domain include heme in the oxygen sensor FixL, FAD in the redox potential sensor NifL, and a 4-hydroxycinnamyl chromophore in photoactive yellow protein. Proteins containing the domain often contain other regulatory domains such as response regulator or sensor histidine kinase domains. Other S-box proteins include phytochromes and the aryl hydrocarbon receptor nuclear translocator. [Regulatory functions, Small molecule interactions]


Pssm-ID: 272971 [Multi-domain]  Cd Length: 124  Bit Score: 48.44  E-value: 8.85e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502876326  241 SETQFRSLIERMHDGLVVLDNDHRIHYVNDRFAQILFRTVDELKGSDIVSLAALPSQAELKMLLLSANVCSSSPCEIE-W 319
Cdd:TIGR00229   1 SEERYRAIFESSPDAIIVIDLEGNILYVNPAFEEIFGYSAEELIGRNVLELIPEEDREEVRERIERRLEGEPEPVSEErR 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
gi 502876326  320 QLPASLKCITLTAVGyQELDDHGAKALFL-IVTDISDRKLAEDRL 363
Cdd:TIGR00229  81 VRRKDGSEIWVEVSV-SPIRTNGGELGVVgIVRDITERKEAEEAL 124
PRK10604 PRK10604
sensor protein RstB; Provisional
 535-648 9.39e-07

sensor protein RstB; Provisional


Pssm-ID: 236724 [Multi-domain]  Cd Length: 433  Bit Score: 51.53  E-value: 9.39e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502876326 535 IQQVLMNLIRNSIQAMSGvsdlprRLTITSFQEDKKLVLVVEDTGPGF--QDNWLTTGPF----PFHTTKSDGLGMGLSI 608
Cdd:PRK10604 320 MERVLDNLLNNALRYAHS------RVRVSLLLDGNQACLIVEDDGPGIppEERERVFEPFvrldPSRDRATGGCGLGLAI 393

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|
gi 502876326 609 SQTLIHSHSGELTLENNSSGGARVSFKLAVIHDNSPSNVA 648
Cdd:PRK10604 394 VHSIALAMGGSVNCDESELGGARFSFSWPVWHNLPQFTSA 433
HATPase_EnvZ-like cd16950
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 535-632 1.79e-06

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli EnvZ and Pseudomonas aeruginosa BfmS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Escherichia coli EnvZ of the EnvZ-OmpR two-component regulatory system (TCS), which functions in osmoregulation. It also contains the HATPase domain of Pseudomonas aeruginosa BfmS, the HK of the BfmSR TCS, which functions in the regulation of the rhl quorum-sensing system and bacterial virulence in P. aeruginosa. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and a HAMP sensor domain; some also contain a periplasmic domain.


Pssm-ID: 340426 [Multi-domain]  Cd Length: 101  Bit Score: 46.67  E-value: 1.79e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502876326 535 IQQVLMNLIRNSIQAMSGvsdlprRLTITSFQEDKKLVLVVEDTGPGFQDNWLTTGPFPFH----TTKSDGLGMGLSISQ 610
Cdd:cd16950    1 LKRVLSNLVDNALRYGGG------WVEVSSDGEGNRTRIQVLDNGPGIAPEEVDELFQPFYrgdnARGTSGTGLGLAIVQ 74

                         90       100
                 ....*....|....*....|....
gi 502876326 611 TLIHSHSGELTLENNSSGG--ARV 632
Cdd:cd16950   75 RISDAHGGSLTLANRAGGGlcARI 98
HATPase_TutC-TodS-like cd16925
Histidine kinase-like ATPase domain of hybrid sensor histidine kinases similar to Pseudomonas ...
 531-636 3.70e-06

Histidine kinase-like ATPase domain of hybrid sensor histidine kinases similar to Pseudomonas putida TodS and Thauera aromatica TutC; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component hybrid sensor histidine kinase (HKs) such Pseudomonas putida TodS HK of the TodS-TodT two-component regulatory system (TCS) which controls the expression of a toluene degradation pathway. Thauera aromatica TutC may be part of a TCS that is involved in anaerobic toluene metabolism. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), PAS sensor domain(s) and a REC domain.


Pssm-ID: 340402 [Multi-domain]  Cd Length: 110  Bit Score: 45.95  E-value: 3.70e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502876326 531 DAVQIQQVLMNLIRNSIQAMSGVSDLPRRLTITsfqEDKKLVLVVEDTGPGFQDNwLTTGPFP-------FHTTKSDGLG 603
Cdd:cd16925    1 DAEKYERVVLNLLSNAFKFTPDGGRIRCILEKF---RLNRFLLTVSDSGPGIPPN-LREEIFErfrqgdgSSTRAHGGTG 76

                         90       100       110
                 ....*....|....*....|....*....|...
gi 502876326 604 MGLSISQTLIHSHSGELTLENNSSGGARVSFKL 636
Cdd:cd16925   77 LGLSIVKEFVELHGGTVTVSDAPGGGALFQVEL 109
HisKA pfam00512
His Kinase A (phospho-acceptor) domain; dimerization and phospho-acceptor domain of histidine ...
 417-483 3.86e-06

His Kinase A (phospho-acceptor) domain; dimerization and phospho-acceptor domain of histidine kinases.


Pssm-ID: 459839 [Multi-domain]  Cd Length: 66  Bit Score: 44.89  E-value: 3.86e-06
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 502876326  417 SLGQLATGIAHEINQPLGAIAAYSEALPLVLQNPDQQsdeaaRIASRIRDAALRAGSIVNRMRSFLR 483
Cdd:pfam00512   1 AKSEFLANLSHELRTPLTAIRGYLELLRDEKLDEEQR-----EYLETILRSAERLLRLINDLLDLSR 62
PAS cd00130
PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising ...
 252-351 7.26e-06

PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in signal transduction.


Pssm-ID: 238075 [Multi-domain]  Cd Length: 103  Bit Score: 44.93  E-value: 7.26e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502876326 252 MHDGLVVLDNDHRIHYVNDRFAQILFRTVDELKGSDIVSLAALPSQAELKMLLLSANVcSSSPCEIEWQLPASLKCITLT 331
Cdd:cd00130    1 LPDGVIVLDLDGRILYANPAAEQLLGYSPEELIGKSLLDLIHPEDREELRERLENLLS-GGEPVTLEVRLRRKDGSVIWV 79

                         90       100
                 ....*....|....*....|
gi 502876326 332 AVGYQELDDHGAKALFLIVT 351
Cdd:cd00130   80 LVSLTPIRDEGGEVIGLLGV 99
HisKA smart00388
His Kinase A (phosphoacceptor) domain; Dimerisation and phosphoacceptor domain of histidine ...
 417-483 9.26e-06

His Kinase A (phosphoacceptor) domain; Dimerisation and phosphoacceptor domain of histidine kinases.


Pssm-ID: 214644 [Multi-domain]  Cd Length: 66  Bit Score: 43.71  E-value: 9.26e-06
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 502876326   417 SLGQLATGIAHEINQPLGAIAAYSEALplvlqNPDQQSDEAARIASRIRDAALRAGSIVNRMRSFLR 483
Cdd:smart00388   1 AKREFLANLSHELRTPLTAIRGYLELL-----LDTELSEEQREYLETILREAERLLRLINDLLDLSR 62
HATPase_BasS-like cd16940
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 523-636 1.27e-05

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli BasS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) similar to Escherichia coli BasS HK of the BasS-BasR two-component regulatory system (TCS). Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some contain a HAMP sensory domain, while some an N-terminal two-component sensor kinase domain.


Pssm-ID: 340417 [Multi-domain]  Cd Length: 113  Bit Score: 44.70  E-value: 1.27e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502876326 523 SEDLCFQGDAVQIQQVLMNLIRNSIQamsgVSDLPRRLTITsFQEDKKLVLVVEDTGPGFQDNWLTT------GPFPFHT 596
Cdd:cd16940    2 AADIQVQGDALLLFLLLRNLVDNAVR----YSPQGSRVEIK-LSADDGAVIRVEDNGPGIDEEELEAlferfyRSDGQNY 76

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|
gi 502876326 597 TksdGLGMGLSISQTLIHSHSGELTLENNSSGGARVSFKL 636
Cdd:cd16940   77 G---GSGLGLSIVKRIVELHGGQIFLGNAQGGGLEAWVRL 113
PAS_8 pfam13188
PAS domain; PAS domains are involved in many signalling proteins where they are used as a ...
 243-303 1.68e-05

PAS domain; PAS domains are involved in many signalling proteins where they are used as a signal sensor domain. PAS domains appear in archaea, bacteria and eukaryotes. Several PAS-domain proteins are known to detect their signal by way of an associated cofactor. Heme, flavin, and a 4-hydroxycinnamyl chromophore are used in different proteins. This domain recognizes oxygen and CO (Matilla et al., FEMS Microbiology Reviews, fuab043, 45, 2021, 1. https://doi.org/10.1093/femsre/fuab043).


Pssm-ID: 463802 [Multi-domain]  Cd Length: 65  Bit Score: 42.92  E-value: 1.68e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 502876326  243 TQFRSLIERMHDGLVVLDNDHRIHYVNDRFAQILFRTVDELKGSDIVSLAALPSQAELKML 303
Cdd:pfam13188   1 ERLRALFESSPDGILVLDEGGRIIYVNPAALELLGYELLGELLGELLDLLDPLLEDALELL 61
HATPase_PhoQ-like cd16954
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 523-633 9.14e-05

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli PhoQ and Providencia stuartii AarG; This family includes histidine kinase-like ATPase (HATPase) domain of two-component sensor histidine kinases similar to Escherichia coli PhoQ and Providencia stuartii AarG. PhoQ is the histidine kinase (HK) of the PhoP-PhoQ two-component regulatory system (TCS), which responds to the levels of Mg2+ and Ca2+, controls virulence, mediates the adaptation to Mg2+-limiting environments, and regulates numerous cellular activities. Providencia stuartii AarG is a putative sensor kinase which controls the expression of the 2'-N-acetyltransferase and an intrinsic multiple antibiotic resistance (Mar) response in Providencia stuartii. The AarG product is similar to PhoQ in that it is able to restore wild-type levels of resistance to a Salmonella typhimurium phoQ mutant. However, the expression of the 2'-N-acetyltransferase gene and of aarP (a gene encoding a transcriptional activator of 2'-N-acetyltransferase) are not significantly affected by the levels of Mg2+ or Ca2+. Most proteins in this group contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some have an accessory HAMP sensor domain, and some have an intracellular membrane -interaction PhoQ sensor domain.


Pssm-ID: 340430 [Multi-domain]  Cd Length: 135  Bit Score: 42.62  E-value: 9.14e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502876326 523 SEDLCFQGDAVQIQQVLMNLIRNSIQAMSgvsdlpRRLTITSFQEDKKLVLVVEDTGPG---------FQ-----Dnwlt 588
Cdd:cd16954   26 SPELRFPGERNDLMELLGNLLDNACKWCL------EFVEVTARQTDGGLHLIVDDDGPGvpesqrskiFQrgqrlD---- 95

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*
gi 502876326 589 tgpfpfhtTKSDGLGMGLSISQTLIHSHSGELTLENNSSGGARVS 633
Cdd:cd16954   96 --------EQRPGQGLGLAIAKEIVEQYGGELSLSDSPLGGARFE 132
YesM COG2972
Sensor histidine kinase YesM [Signal transduction mechanisms];
542-641 1.29e-04

Sensor histidine kinase YesM [Signal transduction mechanisms];


Pssm-ID: 442211 [Multi-domain]  Cd Length: 445  Bit Score: 45.01  E-value: 1.29e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502876326 542 LIRNSIQAmsGVSDLPR--RLTITSFQEDKKLVLVVEDTGPGFQDNWLTTgPFPFHTTKSDGLGMGLSISQTLIHSHSGE 619
Cdd:COG2972  344 LVENAIEH--GIEPKEGggTIRISIRKEGDRLVITVEDNGVGMPEEKLEK-LLEELSSKGEGRGIGLRNVRERLKLYYGE 420

                         90       100
                 ....*....|....*....|....*
gi 502876326 620 ---LTLENNSSGGARVSFKLAVIHD 641
Cdd:COG2972  421 eygLEIESEPGEGTTVTIRIPLEEE 445
HATPase_VanS-like cd16923
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 536-628 1.81e-04

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Enterococcus faecium VanS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Enterococcus faecium VanS HK of the VanS-VanR two-component regulatory system (TCS) which activates the transcription of vanH, vanA and vanX vancomycin resistance genes. It also contains Ecoli YedV and PcoS, probable members of YedW-YedV TCS and PcoS-PcoR TCS, repectively. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); most also have a HAMP sensor domain.


Pssm-ID: 340400 [Multi-domain]  Cd Length: 102  Bit Score: 41.22  E-value: 1.81e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502876326 536 QQVLMNLIRNSIQamsgVSDLPRRLTITSFQEDKKLVLVVEDTGpgfqdnwltTGPFPFHTTK-------------SDGL 602
Cdd:cd16923    2 QRVFSNLLSNAIK----YSPENTRIYITSFLTDDVVNIMFKNPS---------SHPLDFKLEKlferfyrgdnsrnTEGA 68

                         90       100
                 ....*....|....*....|....*.
gi 502876326 603 GMGLSISQTLIHSHSGELTLENNSSG 628
Cdd:cd16923   69 GLGLSIAKAIIELHGGSASAEYDDNH 94
RocR COG3829
RocR-type transcriptional regulator, contains PAS, AAA-type ATPase, and DNA-binding Fis ...
 236-395 2.53e-04

RocR-type transcriptional regulator, contains PAS, AAA-type ATPase, and DNA-binding Fis domains [Transcription, Signal transduction mechanisms];


Pssm-ID: 443041 [Multi-domain]  Cd Length: 448  Bit Score: 43.99  E-value: 2.53e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502876326 236 QRMRISETQFRSLIERMHDGLVVLDNDHRIHYVNDRFAQILFRTVDELKGSDIVSLaaLPSQAELKMLLlsanvcSSSPC 315
Cdd:COG3829    4 LELKELEEELEAILDSLDDGIIVVDADGRITYVNRAAERILGLPREEVIGKNVTEL--IPNSPLLEVLK------TGKPV 75

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502876326 316 EIEWQLPASLKcITLTAVGYQELDDHGAKALFLIVTDISDRKLAEDRLKDAHRELEERVALRTGELRdANDELMHQIKER 395
Cdd:COG3829   76 TGVIQKTGGKG-KTVIVTAIPIFEDGEVIGAVETFRDITELKRLERKLREEELERGLSAKYTFDDII-GKSPAMKELLEL 153
PAS pfam00989
PAS fold; The PAS fold corresponds to the structural domain that has previously been defined ...
 243-307 1.15e-03

PAS fold; The PAS fold corresponds to the structural domain that has previously been defined as PAS and PAC motifs. The PAS fold appears in archaea, eubacteria and eukarya. This domain can bind gases (O2, CO and NO), FAD, 4-hydroxycinnamic acid and NAD+ (Matilla et.al., FEMS Microbiology Reviews, fuab043, 45, 2021, 1. https://doi.org/10.1093/femsre/fuab043).


Pssm-ID: 395786 [Multi-domain]  Cd Length: 113  Bit Score: 38.94  E-value: 1.15e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 502876326  243 TQFRSLIERMHDGLVVLDNDHRIHYVNDRFAQILFRTVDELKGSDIVSLAALPSQAELKMLLLSA 307
Cdd:pfam00989   1 EDLRAILESLPDGIFVVDEDGRILYVNAAAEELLGLSREEVIGKSLLDLIPEEDDAEVAELLRQA 65
PRK11086 PRK11086
sensory histidine kinase DcuS; Provisional
 538-623 1.17e-03

sensory histidine kinase DcuS; Provisional


Pssm-ID: 236839 [Multi-domain]  Cd Length: 542  Bit Score: 41.82  E-value: 1.17e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502876326 538 VLMNLIRNSIQAMSGVSDlpRRLTITSFQEDKKLVLVVEDTGPGF----QDNWLTTGpfpfHTTKSDGLGMGLSISQTLI 613
Cdd:PRK11086 437 ILGNLIENALEAVGGEEG--GEISVSLHYRNGWLHCEVSDDGPGIapdeIDAIFDKG----YSTKGSNRGVGLYLVKQSV 510

                         90
                 ....*....|
gi 502876326 614 HSHSGELTLE 623
Cdd:PRK11086 511 ENLGGSIAVE 520
LytS COG3275
Sensor histidine kinase, LytS/YehU family [Signal transduction mechanisms];
559-636 2.18e-03

Sensor histidine kinase, LytS/YehU family [Signal transduction mechanisms];


Pssm-ID: 442506 [Multi-domain]  Cd Length: 352  Bit Score: 40.62  E-value: 2.18e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502876326 559 RLTITSFQEDKKLVLVVEDTGPGFQDNwlttgpfpfhtTKSDGLGMGLSISQ---TLIHSHSGELTLENNSSGGARVSFK 635
Cdd:COG3275  278 TISISIEVEGDRLVIEVENNGVGIQPK-----------KKKKGSGIGLKNVRerlELLYGDKYSLEIESTDGGGTKVTLK 346


                 .
gi 502876326 636 L 636
Cdd:COG3275  347 I 347
PRK09303 PRK09303
histidine kinase;
425-638 2.83e-03

histidine kinase;


Pssm-ID: 236462 [Multi-domain]  Cd Length: 380  Bit Score: 40.32  E-value: 2.83e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502876326 425 IAHEINQPLGAIAAYSEALPLVLQNPDQQSDEAARiaSRIRDAALRAGSIVNRM-RSFLRTSKSEMRLLSINP------- 496
Cdd:PRK09303 158 LAHDLRTPLTAASLALETLELGQIDEDTELKPALI--EQLQDQARRQLEEIERLiTDLLEVGRTRWEALRFNPqkldlgs 235

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502876326 497 LIEEVLALCSNELSEQRIEVakNTSDSEDL-CFQGDAVQIQQVLMNLIRNSIQAMSG-----VSDLPRrltiTSfqedKK 570
Cdd:PRK09303 236 LCQEVILELEKRWLAKSLEI--QTDIPSDLpSVYADQERIRQVLLNLLDNAIKYTPEggtitLSMLHR----TT----QK 305

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502876326 571 LVLVVEDTGPG---------FQDNwlttgpfpFHTTKS---DGLGMGLSISQTLIHSHSGELTLENNSSGGARVSFKLAV 638
Cdd:PRK09303 306 VQVSICDTGPGipeeeqeriFEDR--------VRLPRDegtEGYGIGLSVCRRIVRVHYGQIWVDSEPGQGSCFHFTLPV 377
HATPase_AgrC-ComD-like cd16935
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 538-625 3.17e-03

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Staphylococcus aureus AgrC and Streptococcus pneumoniae ComD which are involved in quorum sensing; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) including Staphylococcus aureus AgrC which is an HK of the accessory gene regulator (agr) quorum sensing two-component regulatory system (TCS) AgrC-AgrA. The agr system plays a part in the transition from persistent to virulent phenotype. This family also includes Streptococcus pneumoniae ComD HK of the ComD-ComE TCS, involved in quorum sensing and genetic competence.


Pssm-ID: 340412 [Multi-domain]  Cd Length: 134  Bit Score: 38.33  E-value: 3.17e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502876326 538 VLMNLIRNSIQAMSGVSDLPRRLTITSFQEDKKLVLVVEDTGPGfQDNWLTTgpfPFHTTKSDGL-GMGLSISQTLIHSH 616
Cdd:cd16935   40 IFGNLLDNAIEACAKIDKENRFIHLKIRQKKGFLIISIENSYEG-ELKKKNG---LFLSTKKDKNhGIGLKSIREIVKKY 115


                 ....*....
gi 502876326 617 SGELTLENN 625
Cdd:cd16935  116 NGNLSIEYE 124
HATPase_CckA-like cd16919
Histidine kinase-like ATPase domain of two-component sensor hybrid histidine kinases, similar ...
 536-633 4.28e-03

Histidine kinase-like ATPase domain of two-component sensor hybrid histidine kinases, similar to Brucella abortus 2308 CckA; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component hybrid sensor histidine kinase (HKs) similar to Brucella abortus 2308 CckA, which is a component of an essential protein phosphorelay that regulates expression of genes required for growth, division, and intracellular survival; phosphoryl transfer initiates from the sensor kinase CckA and proceeds via the ChpT phosphotransferase to two regulatory substrates: the DNA-binding response regulator CtrA and the phospho-receiver protein CpdR. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), a REC signal receiver domain, and some contain PAS or PAS and GAF sensor domain(s).


Pssm-ID: 340396 [Multi-domain]  Cd Length: 116  Bit Score: 37.36  E-value: 4.28e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502876326 536 QQVLMNLIRNSIQAMsgvsdlPR--RLTITSFQE----DKK-----------LVLVVEDTGPGFQDNWLTTGPFPFHTTK 598
Cdd:cd16919    2 ELAILNLAVNARDAM------PEggRLTIETSNQrvdaDYAlnyrdlipgnyVCLEVSDTGSGMPAEVLRRAFEPFFTTK 75

                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 502876326 599 --SDGLGMGLSISQTLIHSHSGELTLENNSSGGARVS 633
Cdd:cd16919   76 evGKGTGLGLSMVYGFVKQSGGHLRIYSEPGVGTTVR 112
PRK10815 PRK10815
two-component system sensor histidine kinase PhoQ;
562-632 6.02e-03

two-component system sensor histidine kinase PhoQ;


Pssm-ID: 182754 [Multi-domain]  Cd Length: 485  Bit Score: 39.62  E-value: 6.02e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502876326 562 ITSFQEDKKLVLVVEDTGPGFQDNwlttgpfpfhttKSD--------------GLGMGLSISQTLIHSHSGELTLENNSS 627
Cdd:PRK10815 400 ISARQTDEHLHIVVEDDGPGIPES------------KRElifdrgqradtlrpGQGLGLSVAREITEQYEGKISAGDSPL 467


                 ....*
gi 502876326 628 GGARV 632
Cdd:PRK10815 468 GGARM 472
HATPase_CreC-like cd16945
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 531-629 9.48e-03

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli CreC; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Escherichia coli CreC of the CreC-CreB two-component regulatory system (TCS) involved in catabolic regulation. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), and accessory sensory domain(s) such as HAMP, CACHE or PAS.


Pssm-ID: 340421 [Multi-domain]  Cd Length: 106  Bit Score: 36.28  E-value: 9.48e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502876326 531 DAVQIQQVLMNLIRNSIqAMSGVSDLprrLTITSFQEDKKLVLVVEDTGPGFQDNWLT-------TGPFPFHTTKSDGLG 603
Cdd:cd16945    1 DPFLLRQAINNLLDNAI-DFSPEGGL---IALQLEADTEGIELLVFDEGSGIPDYALNrvferfySLPRPHSGQKSTGLG 76

                         90       100
                 ....*....|....*....|....*.
gi 502876326 604 mgLSISQTLIHSHSGELTLENNSSGG 629
Cdd:cd16945   77 --LAFVQEVAQLHGGRITLRNRPDGV 100
cpxA PRK09470
envelope stress sensor histidine kinase CpxA;
539-636 9.88e-03

envelope stress sensor histidine kinase CpxA;


Pssm-ID: 236532 [Multi-domain]  Cd Length: 461  Bit Score: 38.76  E-value: 9.88e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502876326 539 LMNLIRNSIQ-AMSGVSdlprrltiTSFQEDKK-LVLVVEDTGPGFQDNWLTTGPFPFHTT------KSDGLGMGLSISQ 610
Cdd:PRK09470 358 LENIVRNALRySHTKIE--------VAFSVDKDgLTITVDDDGPGVPEEEREQIFRPFYRVdeardrESGGTGLGLAIVE 429

                         90       100
                 ....*....|....*....|....*.
gi 502876326 611 TLIHSHSGELTLENNSSGGARVSFKL 636
Cdd:PRK09470 430 NAIQQHRGWVKAEDSPLGGLRLTIWL 455
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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