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Conserved domains on  [gi|502901816|ref|WP_013136792|]
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CoA ester lyase [Arcobacter nitrofigilis]

Protein Classification

HpcH/HpaI aldolase/citrate lyase family protein( domain architecture ID 10006304)

HpcH/HpaI aldolase/citrate lyase family protein; similar to 4-hydroxy-2-ketoheptane-1,7-dioate (HKHD) aldolase (HpcH/HpaI) that catalyzes the reversible retro-aldol cleavage of HKHD to pyruvate and succinic semialdehyde, and to citrate lyase beta subunit CitE that is an enzymic subunit of citrate lyase, and cleaves citryl-CoA to oxaloacetate and acetyl CoA derivative

CATH:  3.20.20.60
Gene Ontology:  GO:0046872|GO:0016829
SCOP:  4003274

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
CitE COG2301
Citrate lyase beta subunit [Carbohydrate transport and metabolism];
53-348 3.03e-54

Citrate lyase beta subunit [Carbohydrate transport and metabolism];


:

Pssm-ID: 441876  Cd Length: 288  Bit Score: 180.35  E-value: 3.03e-54
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502901816  53 RLQKhAYKTKAHTVLFDLEDGC--RQKAMSRELLIQELPKFPQRDFQIAIRINPFRTDEYEEDLKMLKQVHkyIDAIVLA 130
Cdd:COG2301   19 RLAK-ALASGADAVILDLEDAVapDEKDAARENVAEALAELDFGGPEVFVRINALDTPWGLDDLAALVGAG--LDGIVLP 95

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502901816 131 KAGEVygdAEIRDLSSWLVSI---GSSLQIQPIIEHPKSLQIADRLMSHST-VQHVVFGIHDFSKAMAYKITPEGwiDEL 206
Cdd:COG2301   96 KVESA---EDVRALAALLTELeaeGGSIPLMALIETARGLLNAAEIAAASPrVEALVFGAEDLAADLGARRTRDG--DEL 170

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502901816 207 ETFFNMLTMEARIKGKGVIGGVevlltpnslpdscvekkdirrWLDLHGDNAsrhVYEHAKRETAMGLTGKQVITPNHIN 286
Cdd:COG2301  171 LYARSRIVLAARAAGLAAIDGV---------------------YTDFRDLEG---LRAEARRARALGFDGKTAIHPSQIA 226

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 502901816 287 VCKVAFTPSPKEIAKDIEILSAAIEADAllSGAIRYKGEMLDPPMFGKSLQNLLRGYALRSL 348
Cdd:COG2301  227 VINEAFAPSEEEVAWARRILAAFEEAEA--KGVVSLDGKMVDRPHLRRARRILARARAIGVR 286
 
Name Accession Description Interval E-value
CitE COG2301
Citrate lyase beta subunit [Carbohydrate transport and metabolism];
53-348 3.03e-54

Citrate lyase beta subunit [Carbohydrate transport and metabolism];


Pssm-ID: 441876  Cd Length: 288  Bit Score: 180.35  E-value: 3.03e-54
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502901816  53 RLQKhAYKTKAHTVLFDLEDGC--RQKAMSRELLIQELPKFPQRDFQIAIRINPFRTDEYEEDLKMLKQVHkyIDAIVLA 130
Cdd:COG2301   19 RLAK-ALASGADAVILDLEDAVapDEKDAARENVAEALAELDFGGPEVFVRINALDTPWGLDDLAALVGAG--LDGIVLP 95

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502901816 131 KAGEVygdAEIRDLSSWLVSI---GSSLQIQPIIEHPKSLQIADRLMSHST-VQHVVFGIHDFSKAMAYKITPEGwiDEL 206
Cdd:COG2301   96 KVESA---EDVRALAALLTELeaeGGSIPLMALIETARGLLNAAEIAAASPrVEALVFGAEDLAADLGARRTRDG--DEL 170

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502901816 207 ETFFNMLTMEARIKGKGVIGGVevlltpnslpdscvekkdirrWLDLHGDNAsrhVYEHAKRETAMGLTGKQVITPNHIN 286
Cdd:COG2301  171 LYARSRIVLAARAAGLAAIDGV---------------------YTDFRDLEG---LRAEARRARALGFDGKTAIHPSQIA 226

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 502901816 287 VCKVAFTPSPKEIAKDIEILSAAIEADAllSGAIRYKGEMLDPPMFGKSLQNLLRGYALRSL 348
Cdd:COG2301  227 VINEAFAPSEEEVAWARRILAAFEEAEA--KGVVSLDGKMVDRPHLRRARRILARARAIGVR 286
 
Name Accession Description Interval E-value
CitE COG2301
Citrate lyase beta subunit [Carbohydrate transport and metabolism];
53-348 3.03e-54

Citrate lyase beta subunit [Carbohydrate transport and metabolism];


Pssm-ID: 441876  Cd Length: 288  Bit Score: 180.35  E-value: 3.03e-54
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502901816  53 RLQKhAYKTKAHTVLFDLEDGC--RQKAMSRELLIQELPKFPQRDFQIAIRINPFRTDEYEEDLKMLKQVHkyIDAIVLA 130
Cdd:COG2301   19 RLAK-ALASGADAVILDLEDAVapDEKDAARENVAEALAELDFGGPEVFVRINALDTPWGLDDLAALVGAG--LDGIVLP 95

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502901816 131 KAGEVygdAEIRDLSSWLVSI---GSSLQIQPIIEHPKSLQIADRLMSHST-VQHVVFGIHDFSKAMAYKITPEGwiDEL 206
Cdd:COG2301   96 KVESA---EDVRALAALLTELeaeGGSIPLMALIETARGLLNAAEIAAASPrVEALVFGAEDLAADLGARRTRDG--DEL 170

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502901816 207 ETFFNMLTMEARIKGKGVIGGVevlltpnslpdscvekkdirrWLDLHGDNAsrhVYEHAKRETAMGLTGKQVITPNHIN 286
Cdd:COG2301  171 LYARSRIVLAARAAGLAAIDGV---------------------YTDFRDLEG---LRAEARRARALGFDGKTAIHPSQIA 226

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 502901816 287 VCKVAFTPSPKEIAKDIEILSAAIEADAllSGAIRYKGEMLDPPMFGKSLQNLLRGYALRSL 348
Cdd:COG2301  227 VINEAFAPSEEEVAWARRILAAFEEAEA--KGVVSLDGKMVDRPHLRRARRILARARAIGVR 286
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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