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Conserved domains on  [gi|502923448|ref|WP_013158424|]
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50S ribosomal protein L11 methyltransferase [Meiothermus silvanus]

Protein Classification

50S ribosomal protein L11 methyltransferase( domain architecture ID 11455142)

50S ribosomal protein L11 methyltransferase is a class I SAM-dependent methyltransferase that methylates ribosomal protein L11 using S-adenosyl-L-methionine (SAM or AdoMet) as the methyl donor

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PrmA COG2264
Ribosomal protein L11 methylase PrmA [Translation, ribosomal structure and biogenesis];
4-253 7.66e-90

Ribosomal protein L11 methylase PrmA [Translation, ribosomal structure and biogenesis];


:

Pssm-ID: 441865 [Multi-domain]  Cd Length: 284  Bit Score: 267.04  E-value: 7.66e-90
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502923448   4 FRLKGNFETLDAYTPLLFDLGARG--LEEKPGEVW------AYFPTRLEL---------------PLPGEWAELPDTDWL 60
Cdd:COG2264    6 LTITTPEEAAEALSDALEELGAEGveIEDAPPGLWervgvkAYFPEDEDLeellaalaealgelgAPEITVEEVEEEDWV 85

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502923448  61 EAWRRDLKPVRAGP-FVVLAPWHRWEGPEQR--ILLEPGMAFGTGHHETTRMALEALAERVKPGMRVLDLGTGSGILAIA 137
Cdd:COG2264   86 EEWKKYFKPIRVGDrLVIVPSWEEYEPDPGEivIEIDPGMAFGTGTHPTTRLCLEALEKLLKPGKTVLDVGCGSGILAIA 165

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502923448 138 AQMLGA-WAVGVDNDPAVIPQARHNAAANGVSP--EFFLGTLEnAHGVFDLIVANLYAELHAELAPLYPTYLVQGGHMLM 214
Cdd:COG2264  166 AAKLGAkRVLAVDIDPVAVEAARENAELNGVEDriEVVLGDLL-EDGPYDLVVANILANPLIELAPDLAALLKPGGYLIL 244

                        250       260       270
                 ....*....|....*....|....*....|....*....
gi 502923448 215 TGILSERERLVDNAMRAQGFESLHRRPEGEWVHLIYRKP 253
Cdd:COG2264  245 SGILEEQADEVLAAYEAAGFELVERRERGEWVALVLRKK 283
 
Name Accession Description Interval E-value
PrmA COG2264
Ribosomal protein L11 methylase PrmA [Translation, ribosomal structure and biogenesis];
4-253 7.66e-90

Ribosomal protein L11 methylase PrmA [Translation, ribosomal structure and biogenesis];


Pssm-ID: 441865 [Multi-domain]  Cd Length: 284  Bit Score: 267.04  E-value: 7.66e-90
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502923448   4 FRLKGNFETLDAYTPLLFDLGARG--LEEKPGEVW------AYFPTRLEL---------------PLPGEWAELPDTDWL 60
Cdd:COG2264    6 LTITTPEEAAEALSDALEELGAEGveIEDAPPGLWervgvkAYFPEDEDLeellaalaealgelgAPEITVEEVEEEDWV 85

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502923448  61 EAWRRDLKPVRAGP-FVVLAPWHRWEGPEQR--ILLEPGMAFGTGHHETTRMALEALAERVKPGMRVLDLGTGSGILAIA 137
Cdd:COG2264   86 EEWKKYFKPIRVGDrLVIVPSWEEYEPDPGEivIEIDPGMAFGTGTHPTTRLCLEALEKLLKPGKTVLDVGCGSGILAIA 165

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502923448 138 AQMLGA-WAVGVDNDPAVIPQARHNAAANGVSP--EFFLGTLEnAHGVFDLIVANLYAELHAELAPLYPTYLVQGGHMLM 214
Cdd:COG2264  166 AAKLGAkRVLAVDIDPVAVEAARENAELNGVEDriEVVLGDLL-EDGPYDLVVANILANPLIELAPDLAALLKPGGYLIL 244

                        250       260       270
                 ....*....|....*....|....*....|....*....
gi 502923448 215 TGILSERERLVDNAMRAQGFESLHRRPEGEWVHLIYRKP 253
Cdd:COG2264  245 SGILEEQADEVLAAYEAAGFELVERRERGEWVALVLRKK 283
prmA PRK00517
50S ribosomal protein L11 methyltransferase;
4-253 1.82e-87

50S ribosomal protein L11 methyltransferase;


Pssm-ID: 234786 [Multi-domain]  Cd Length: 250  Bit Score: 259.70  E-value: 1.82e-87
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502923448   4 FRLKGNFETLDAYTPLLFDLGARGLEEKPGEVWAYFPtrlelPLPGEWAELPDTDWLEAWRRDLKPVRAGP-FVVLAPWH 82
Cdd:PRK00517   6 LTLNTTPEAAEALSDILMELGALAALANLAGLGLDLG-----EPTYTIEEVEDEDWEREWKKYFHPIRIGDrLWIVPSWE 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502923448  83 RWEGP-EQRILLEPGMAFGTGHHETTRMALEALAERVKPGMRVLDLGTGSGILAIAAQMLGAWAV-GVDNDPAVIPQARH 160
Cdd:PRK00517  81 DPPDPdEINIELDPGMAFGTGTHPTTRLCLEALEKLVLPGKTVLDVGCGSGILAIAAAKLGAKKVlAVDIDPQAVEAARE 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502923448 161 NAAANGVSPEFFLGTlenAHGVFDLIVANLYAELHAELAPLYPTYLVQGGHMLMTGILSERERLVDNAMRAQGFESLHRR 240
Cdd:PRK00517 161 NAELNGVELNVYLPQ---GDLKADVIVANILANPLLELAPDLARLLKPGGRLILSGILEEQADEVLEAYEEAGFTLDEVL 237

                        250
                 ....*....|...
gi 502923448 241 PEGEWVHLIYRKP 253
Cdd:PRK00517 238 ERGEWVALVGKKK 250
PrmA pfam06325
Ribosomal protein L11 methyltransferase (PrmA); This family consists of several Ribosomal ...
 5-252 1.97e-61

Ribosomal protein L11 methyltransferase (PrmA); This family consists of several Ribosomal protein L11 methyltransferase (EC:2.1.1.-) sequences.


Pssm-ID: 428888 [Multi-domain]  Cd Length: 294  Bit Score: 194.79  E-value: 1.97e-61
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502923448    5 RLKGNFETLDAYTPLLFDLGARG--------------LEEKPGE--------VWAYFPT---------RLELPLPG---- 49
Cdd:pfam06325   6 SIHTTREAAEPVSNILEEFGALGvaiedadlledrdiFEPGLGEerlwdevrVKALFDEetdaleliaQLAELIGGldsp 85

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502923448   50 --EWAELPDTDWLEAWRRDLKPVRAGPFVVLAPWhrWEGPEQR-----ILLEPGMAFGTGHHETTRMALEALAERVKPGM 122
Cdd:pfam06325  86 kvTVEEVAEEDWARAWKKYFHPVRIGERLTIVPS--WEDYPENpdalnIELDPGMAFGTGTHPTTKLCLEALERLVKPGE 163

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502923448  123 RVLDLGTGSGILAIAAQMLGA-WAVGVDNDPAVIPQARHNAAANGVSPEFFLGTLENA-HGVFDLIVANLYAELHAELAP 200
Cdd:pfam06325 164 SVLDVGCGSGILAIAALKLGAkKVVGVDIDPVAVRAAKENAELNGVEARLEVYLPGDLpKEKADVVVANILADPLIELAP 243

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|..
gi 502923448  201 LYPTYLVQGGHMLMTGILSERERLVDNAMrAQGFESLHRRPEGEWVHLIYRK 252
Cdd:pfam06325 244 DIYALVKPGGYLILSGILKEQAQMVAEAY-SQGFELITVEHREEWVCIVGKK 294
prmA TIGR00406
ribosomal protein L11 methyltransferase; Ribosomal protein L11 methyltransferase is an ...
 56-246 2.75e-48

ribosomal protein L11 methyltransferase; Ribosomal protein L11 methyltransferase is an S-adenosyl-L-methionine-dependent methyltransferase required for the modification of ribosomal protein L11. This protein is found in bacteria and (with a probable transit peptide) in Arabidopsis. [Protein synthesis, Ribosomal proteins: synthesis and modification]


Pssm-ID: 273061  Cd Length: 288  Bit Score: 161.16  E-value: 2.75e-48
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502923448   56 DTDWLEAWRRDLKPVRAG-PFVVLAPWHRWEGPEQR--ILLEPGMAFGTGHHETTRMALEALAERVKPGMRVLDLGTGSG 132
Cdd:TIGR00406  92 SKDWERAWKDNFHPVQFGkRFWICPSWRDVPSDEDAliIMLDPGLAFGTGTHPTTSLCLEWLEDLDLKDKNVIDVGCGSG 171

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502923448  133 ILAIAAQMLGAW-AVGVDNDPAVIPQARHNAAANGVSPE---FFLGTLENAHGVFDLIVANLYAELHAELAPLYPTYLVQ 208
Cdd:TIGR00406 172 ILSIAALKLGAAkVVGIDIDPLAVESARKNAELNQVSDRlqvKLIYLEQPIEGKADVIVANILAEVIKELYPQFSRLVKP 251

                         170       180       190
                  ....*....|....*....|....*....|....*...
gi 502923448  209 GGHMLMTGILSERERLVDNAMrAQGFESLHRRPEGEWV 246
Cdd:TIGR00406 252 GGWLILSGILETQAQSVCDAY-EQGFTVVEIRQREEWC 288
AdoMet_MTases cd02440
S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; ...
 123-215 3.49e-07

S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). There are at least five structurally distinct families of AdoMet-MTases, class I being the largest and most diverse. Within this class enzymes can be classified by different substrate specificities (small molecules, lipids, nucleic acids, etc.) and different target atoms for methylation (nitrogen, oxygen, carbon, sulfur, etc.).


Pssm-ID: 100107 [Multi-domain]  Cd Length: 107  Bit Score: 47.42  E-value: 3.49e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502923448 123 RVLDLGTGSGILAIAAQMLGAWAV-GVDNDPAVIPQARHNAAANGVSP-EFFLGTLENAHGV----FDLIVANL----YA 192
Cdd:cd02440    1 RVLDLGCGTGALALALASGPGARVtGVDISPVALELARKAAAALLADNvEVLKGDAEELPPEadesFDVIISDPplhhLV 80

                         90       100
                 ....*....|....*....|...
gi 502923448 193 ELHAELAPLYPTYLVQGGHMLMT 215
Cdd:cd02440   81 EDLARFLEEARRLLKPGGVLVLT 103
 
Name Accession Description Interval E-value
PrmA COG2264
Ribosomal protein L11 methylase PrmA [Translation, ribosomal structure and biogenesis];
4-253 7.66e-90

Ribosomal protein L11 methylase PrmA [Translation, ribosomal structure and biogenesis];


Pssm-ID: 441865 [Multi-domain]  Cd Length: 284  Bit Score: 267.04  E-value: 7.66e-90
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502923448   4 FRLKGNFETLDAYTPLLFDLGARG--LEEKPGEVW------AYFPTRLEL---------------PLPGEWAELPDTDWL 60
Cdd:COG2264    6 LTITTPEEAAEALSDALEELGAEGveIEDAPPGLWervgvkAYFPEDEDLeellaalaealgelgAPEITVEEVEEEDWV 85

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502923448  61 EAWRRDLKPVRAGP-FVVLAPWHRWEGPEQR--ILLEPGMAFGTGHHETTRMALEALAERVKPGMRVLDLGTGSGILAIA 137
Cdd:COG2264   86 EEWKKYFKPIRVGDrLVIVPSWEEYEPDPGEivIEIDPGMAFGTGTHPTTRLCLEALEKLLKPGKTVLDVGCGSGILAIA 165

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502923448 138 AQMLGA-WAVGVDNDPAVIPQARHNAAANGVSP--EFFLGTLEnAHGVFDLIVANLYAELHAELAPLYPTYLVQGGHMLM 214
Cdd:COG2264  166 AAKLGAkRVLAVDIDPVAVEAARENAELNGVEDriEVVLGDLL-EDGPYDLVVANILANPLIELAPDLAALLKPGGYLIL 244

                        250       260       270
                 ....*....|....*....|....*....|....*....
gi 502923448 215 TGILSERERLVDNAMRAQGFESLHRRPEGEWVHLIYRKP 253
Cdd:COG2264  245 SGILEEQADEVLAAYEAAGFELVERRERGEWVALVLRKK 283
prmA PRK00517
50S ribosomal protein L11 methyltransferase;
4-253 1.82e-87

50S ribosomal protein L11 methyltransferase;


Pssm-ID: 234786 [Multi-domain]  Cd Length: 250  Bit Score: 259.70  E-value: 1.82e-87
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502923448   4 FRLKGNFETLDAYTPLLFDLGARGLEEKPGEVWAYFPtrlelPLPGEWAELPDTDWLEAWRRDLKPVRAGP-FVVLAPWH 82
Cdd:PRK00517   6 LTLNTTPEAAEALSDILMELGALAALANLAGLGLDLG-----EPTYTIEEVEDEDWEREWKKYFHPIRIGDrLWIVPSWE 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502923448  83 RWEGP-EQRILLEPGMAFGTGHHETTRMALEALAERVKPGMRVLDLGTGSGILAIAAQMLGAWAV-GVDNDPAVIPQARH 160
Cdd:PRK00517  81 DPPDPdEINIELDPGMAFGTGTHPTTRLCLEALEKLVLPGKTVLDVGCGSGILAIAAAKLGAKKVlAVDIDPQAVEAARE 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502923448 161 NAAANGVSPEFFLGTlenAHGVFDLIVANLYAELHAELAPLYPTYLVQGGHMLMTGILSERERLVDNAMRAQGFESLHRR 240
Cdd:PRK00517 161 NAELNGVELNVYLPQ---GDLKADVIVANILANPLLELAPDLARLLKPGGRLILSGILEEQADEVLEAYEEAGFTLDEVL 237

                        250
                 ....*....|...
gi 502923448 241 PEGEWVHLIYRKP 253
Cdd:PRK00517 238 ERGEWVALVGKKK 250
PrmA pfam06325
Ribosomal protein L11 methyltransferase (PrmA); This family consists of several Ribosomal ...
 5-252 1.97e-61

Ribosomal protein L11 methyltransferase (PrmA); This family consists of several Ribosomal protein L11 methyltransferase (EC:2.1.1.-) sequences.


Pssm-ID: 428888 [Multi-domain]  Cd Length: 294  Bit Score: 194.79  E-value: 1.97e-61
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502923448    5 RLKGNFETLDAYTPLLFDLGARG--------------LEEKPGE--------VWAYFPT---------RLELPLPG---- 49
Cdd:pfam06325   6 SIHTTREAAEPVSNILEEFGALGvaiedadlledrdiFEPGLGEerlwdevrVKALFDEetdaleliaQLAELIGGldsp 85

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502923448   50 --EWAELPDTDWLEAWRRDLKPVRAGPFVVLAPWhrWEGPEQR-----ILLEPGMAFGTGHHETTRMALEALAERVKPGM 122
Cdd:pfam06325  86 kvTVEEVAEEDWARAWKKYFHPVRIGERLTIVPS--WEDYPENpdalnIELDPGMAFGTGTHPTTKLCLEALERLVKPGE 163

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502923448  123 RVLDLGTGSGILAIAAQMLGA-WAVGVDNDPAVIPQARHNAAANGVSPEFFLGTLENA-HGVFDLIVANLYAELHAELAP 200
Cdd:pfam06325 164 SVLDVGCGSGILAIAALKLGAkKVVGVDIDPVAVRAAKENAELNGVEARLEVYLPGDLpKEKADVVVANILADPLIELAP 243

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|..
gi 502923448  201 LYPTYLVQGGHMLMTGILSERERLVDNAMrAQGFESLHRRPEGEWVHLIYRK 252
Cdd:pfam06325 244 DIYALVKPGGYLILSGILKEQAQMVAEAY-SQGFELITVEHREEWVCIVGKK 294
prmA TIGR00406
ribosomal protein L11 methyltransferase; Ribosomal protein L11 methyltransferase is an ...
 56-246 2.75e-48

ribosomal protein L11 methyltransferase; Ribosomal protein L11 methyltransferase is an S-adenosyl-L-methionine-dependent methyltransferase required for the modification of ribosomal protein L11. This protein is found in bacteria and (with a probable transit peptide) in Arabidopsis. [Protein synthesis, Ribosomal proteins: synthesis and modification]


Pssm-ID: 273061  Cd Length: 288  Bit Score: 161.16  E-value: 2.75e-48
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502923448   56 DTDWLEAWRRDLKPVRAG-PFVVLAPWHRWEGPEQR--ILLEPGMAFGTGHHETTRMALEALAERVKPGMRVLDLGTGSG 132
Cdd:TIGR00406  92 SKDWERAWKDNFHPVQFGkRFWICPSWRDVPSDEDAliIMLDPGLAFGTGTHPTTSLCLEWLEDLDLKDKNVIDVGCGSG 171

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502923448  133 ILAIAAQMLGAW-AVGVDNDPAVIPQARHNAAANGVSPE---FFLGTLENAHGVFDLIVANLYAELHAELAPLYPTYLVQ 208
Cdd:TIGR00406 172 ILSIAALKLGAAkVVGIDIDPLAVESARKNAELNQVSDRlqvKLIYLEQPIEGKADVIVANILAEVIKELYPQFSRLVKP 251

                         170       180       190
                  ....*....|....*....|....*....|....*...
gi 502923448  209 GGHMLMTGILSERERLVDNAMrAQGFESLHRRPEGEWV 246
Cdd:TIGR00406 252 GGWLILSGILETQAQSVCDAY-EQGFTVVEIRQREEWC 288
UbiE COG2226
Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG [Coenzyme transport and metabolism]; ...
 102-235 4.33e-16

Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG [Coenzyme transport and metabolism]; Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG is part of the Pathway/BioSystem: Biotin biosynthesis


Pssm-ID: 441828 [Multi-domain]  Cd Length: 143  Bit Score: 72.72  E-value: 4.33e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502923448 102 GHHETTRMALEALAerVKPGMRVLDLGTGSGILAIAAQMLGAWAVGVDNDPAVIPQARHNAAANGVSPEFFLGTLEN--- 178
Cdd:COG2226    6 ARYDGREALLAALG--LRPGARVLDLGCGTGRLALALAERGARVTGVDISPEMLELARERAAEAGLNVEFVVGDAEDlpf 83

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 502923448 179 AHGVFDLIVANL-----------YAELHAELAPlyptylvqGGHMLMTGILSERERLVDNAMRAQGFE 235
Cdd:COG2226   84 PDGSFDLVISSFvlhhlpdperaLAEIARVLKP--------GGRLVVVDFSPPDLAELEELLAEAGFE 143
RF_mod_PrmC TIGR03534
protein-(glutamine-N5) methyltransferase, release factor-specific; Members of this protein ...
 104-189 4.01e-14

protein-(glutamine-N5) methyltransferase, release factor-specific; Members of this protein family are HemK (PrmC), a protein once thought to be involved in heme biosynthesis but now recognized to be a protein-glutamine methyltransferase that modifies the peptide chain release factors. All members of the seed alignment are encoded next to the release factor 1 gene (prfA) and confirmed by phylogenetic analysis. SIMBAL analysis (manuscript in prep.) shows the motif [LIV]PRx[DE]TE (in Escherichia coli, IPRPDTE) confers specificity for the release factors rather than for ribosomal protein L3. [Protein fate, Protein modification and repair]


Pssm-ID: 274634 [Multi-domain]  Cd Length: 250  Bit Score: 69.81  E-value: 4.01e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502923448  104 HETTRMALEALaERVKPGMRVLDLGTGSGILAIA-AQMLGAWAV-GVDNDPAVIPQARHNAAANGVSP-EFFLG-TLEN- 178
Cdd:TIGR03534  71 PETEELVEAAL-ERLKKGPRVLDLGTGSGAIALAlAKERPDARVtAVDISPEALAVARKNARRLGLENvEFLQGdWFEPl 149

                          90
                  ....*....|.
gi 502923448  179 AHGVFDLIVAN 189
Cdd:TIGR03534 150 PSGKFDLIVSN 160
PRK14968 PRK14968
putative methyltransferase; Provisional
 105-189 8.99e-14

putative methyltransferase; Provisional


Pssm-ID: 237872 [Multi-domain]  Cd Length: 188  Bit Score: 67.62  E-value: 8.99e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502923448 105 ETTRMALEALaeRVKPGMRVLDLGTGSGILAIAAQMLGAWAVGVDNDPAVIPQARHNAAANGVSP---EFFLGTL-EN-A 179
Cdd:PRK14968  10 EDSFLLAENA--VDKKGDRVLEVGTGSGIVAIVAAKNGKKVVGVDINPYAVECAKCNAKLNNIRNngvEVIRSDLfEPfR 87

                         90
                 ....*....|
gi 502923448 180 HGVFDLIVAN 189
Cdd:PRK14968  88 GDKFDVILFN 97
Nnt1 COG3897
Protein N-terminal and lysine N-methylase, NNT1/EFM7 family [Posttranslational modification, ...
 120-214 5.59e-13

Protein N-terminal and lysine N-methylase, NNT1/EFM7 family [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443104 [Multi-domain]  Cd Length: 216  Bit Score: 66.06  E-value: 5.59e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502923448 120 PGMRVLDLGTGSGILAIAAQMLGAWAV-GVDNDPAVIPQARHNAAANGVSPEFFLG--TLENAHGVFDLIVAN--LY-AE 193
Cdd:COG3897   70 AGKRVLELGCGLGLVGIAAAKAGAADVtATDYDPEALAALRLNAALNGVAITTRLGdwRDPPAAGGFDLILGGdvLYeRD 149

                         90       100
                 ....*....|....*....|.
gi 502923448 194 LHAELAPLYPTYLVQGGHMLM 214
Cdd:COG3897  150 LAEPLLPFLDRLAAPGGEVLI 170
HemK COG2890
Methylase of polypeptide chain release factors [Translation, ribosomal structure and ...
 110-189 1.32e-12

Methylase of polypeptide chain release factors [Translation, ribosomal structure and biogenesis];


Pssm-ID: 442135 [Multi-domain]  Cd Length: 282  Bit Score: 65.94  E-value: 1.32e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502923448 110 ALEALAERvkPGMRVLDLGTGSGILAIA-AQMLGAWAV-GVDNDPAVIPQARHNAAANGVSP--EFFLGTLENA---HGV 182
Cdd:COG2890  104 ALALLPAG--APPRVLDLGTGSGAIALAlAKERPDARVtAVDISPDALAVARRNAERLGLEDrvRFLQGDLFEPlpgDGR 181


                 ....*..
gi 502923448 183 FDLIVAN 189
Cdd:COG2890  182 FDLIVSN 188
Cfa COG2230
Cyclopropane fatty-acyl-phospholipid synthase and related methyltransferases [Lipid transport ...
 94-216 2.06e-12

Cyclopropane fatty-acyl-phospholipid synthase and related methyltransferases [Lipid transport and metabolism];


Pssm-ID: 441831 [Multi-domain]  Cd Length: 158  Bit Score: 63.02  E-value: 2.06e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502923448  94 EPGMAFGTGHHETTRMALEALaeRVKPGMRVLDLGTGSGILAI-AAQMLGAWAVGVDNDPAVIPQARHNAAANGVSP--E 170
Cdd:COG2230   27 DPDDTLEEAQEAKLDLILRKL--GLKPGMRVLDIGCGWGGLALyLARRYGVRVTGVTLSPEQLEYARERAAEAGLADrvE 104

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 502923448 171 FFLGTLEN--AHGVFDLIVAN---------LYAELHAELAPLyptyLVQGGHMLMTG 216
Cdd:COG2230  105 VRLADYRDlpADGQFDAIVSIgmfehvgpeNYPAYFAKVARL----LKPGGRLLLHT 157
Methyltransf_25 pfam13649
Methyltransferase domain; This family appears to be a methyltransferase domain.
 124-189 2.60e-12

Methyltransferase domain; This family appears to be a methyltransferase domain.


Pssm-ID: 463945 [Multi-domain]  Cd Length: 96  Bit Score: 61.43  E-value: 2.60e-12
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502923448  124 VLDLGTGSGILAIA-AQMLGAWAVGVDNDPAVIPQARHNAAANGVSPEFFLGTLEN---AHGVFDLIVAN 189
Cdd:pfam13649   1 VLDLGCGTGRLTLAlARRGGARVTGVDLSPEMLERARERAAEAGLNVEFVQGDAEDlpfPDGSFDLVVSS 70
COG2263 COG2263
Predicted RNA methylase [General function prediction only];
108-189 4.39e-12

Predicted RNA methylase [General function prediction only];


Pssm-ID: 441864 [Multi-domain]  Cd Length: 199  Bit Score: 63.00  E-value: 4.39e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502923448 108 RMALEALAERVKPGMRVLDLGTGSGILAIAAQMLGA-WAVGVDNDPAVIPQARHNAAANGVSPEFFLGTLENAH--GVFD 184
Cdd:COG2263   33 ELLHLAYLRGDIEGKTVLDLGCGTGMLAIGAALLGAkKVVGVDIDPEALEIARENAERLGVRVDFIRADVTRIPlgGSVD 112


                 ....*
gi 502923448 185 LIVAN 189
Cdd:COG2263  113 TVVMN 117
UbiG COG2227
2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase [Coenzyme transport and ...
 112-215 4.83e-12

2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase [Coenzyme transport and metabolism]; 2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase is part of the Pathway/BioSystem: Ubiquinone biosynthesis


Pssm-ID: 441829 [Multi-domain]  Cd Length: 126  Bit Score: 61.57  E-value: 4.83e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502923448 112 EALAERVKPGMRVLDLGTGSGILAIAAQMLGAWAVGVDNDPAVIPQARHNAAANGVspEFFLGTLEN---AHGVFDLIVA 188
Cdd:COG2227   16 ALLARLLPAGGRVLDVGCGTGRLALALARRGADVTGVDISPEALEIARERAAELNV--DFVQGDLEDlplEDGSFDLVIC 93

                         90       100       110
                 ....*....|....*....|....*....|....*...
gi 502923448 189 N-----------LYAELHAELAPlyptylvqGGHMLMT 215
Cdd:COG2227   94 SevlehlpdpaaLLRELARLLKP--------GGLLLLS 123
TrmN6 COG4123
tRNA1(Val) A37 N6-methylase TrmN6 [Translation, ribosomal structure and biogenesis]; tRNA1(Val) ...
 117-189 1.03e-11

tRNA1(Val) A37 N6-methylase TrmN6 [Translation, ribosomal structure and biogenesis]; tRNA1(Val) A37 N6-methylase TrmN6 is part of the Pathway/BioSystem: tRNA modification


Pssm-ID: 443299 [Multi-domain]  Cd Length: 238  Bit Score: 62.85  E-value: 1.03e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502923448 117 RVKPGMRVLDLGTGSGILAI--AAQMLGAWAVGVDNDPAVIPQARHNAAANGVSP--EFFLGTL-----ENAHGVFDLIV 187
Cdd:COG4123   34 PVKKGGRVLDLGTGTGVIALmlAQRSPGARITGVEIQPEAAELARRNVALNGLEDriTVIHGDLkefaaELPPGSFDLVV 113


                 ..
gi 502923448 188 AN 189
Cdd:COG4123  114 SN 115
PRK14967 PRK14967
putative methyltransferase; Provisional
 105-189 2.52e-11

putative methyltransferase; Provisional


Pssm-ID: 184931 [Multi-domain]  Cd Length: 223  Bit Score: 61.61  E-value: 2.52e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502923448 105 ETTRMALEALAER-VKPGMRVLDLGTGSGILAIAAQMLGA-WAVGVDNDPAVIPQARHNAAANGVSPEFFLGTLENA--H 180
Cdd:PRK14967  20 EDTQLLADALAAEgLGPGRRVLDLCTGSGALAVAAAAAGAgSVTAVDISRRAVRSARLNALLAGVDVDVRRGDWARAveF 99


                 ....*....
gi 502923448 181 GVFDLIVAN 189
Cdd:PRK14967 100 RPFDVVVSN 108
PRK09328 PRK09328
N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional
 105-189 5.84e-11

N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional


Pssm-ID: 236467 [Multi-domain]  Cd Length: 275  Bit Score: 60.95  E-value: 5.84e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502923448 105 ETTRMALEAL-AERVKPGMRVLDLGTGSGILAIA-AQMLGAWAV-GVDNDPAVIPQARHNAAANGVSP-EFFLGTLENA- 179
Cdd:PRK09328  92 ETEELVEWALeALLLKEPLRVLDLGTGSGAIALAlAKERPDAEVtAVDISPEALAVARRNAKHGLGARvEFLQGDWFEPl 171

                         90
                 ....*....|.
gi 502923448 180 -HGVFDLIVAN 189
Cdd:PRK09328 172 pGGRFDLIVSN 182
SmtA COG0500
SAM-dependent methyltransferase [Secondary metabolites biosynthesis, transport and catabolism, ...
 109-245 1.28e-10

SAM-dependent methyltransferase [Secondary metabolites biosynthesis, transport and catabolism, General function prediction only];


Pssm-ID: 440266 [Multi-domain]  Cd Length: 199  Bit Score: 59.16  E-value: 1.28e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502923448 109 MALEALAERVKPGMRVLDLGTGSGILAIA-AQMLGAWAVGVDNDPAVIPQARHNAAANGVSP-EFFLGTLENAHGV---- 182
Cdd:COG0500   15 AALLALLERLPKGGRVLDLGCGTGRNLLAlAARFGGRVIGIDLSPEAIALARARAAKAGLGNvEFLVADLAELDPLpaes 94

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 502923448 183 FDLIVAN-------------LYAELHAELAPlyptylvqGGHMLMTGILSERERLVDNAMRAQGFESLHRRPEGEW 245
Cdd:COG0500   95 FDLVVAFgvlhhlppeereaLLRELARALKP--------GGVLLLSASDAAAALSLARLLLLATASLLELLLLLRL 162
COG4076 COG4076
Predicted RNA methylase [General function prediction only];
112-168 2.31e-10

Predicted RNA methylase [General function prediction only];


Pssm-ID: 443253 [Multi-domain]  Cd Length: 230  Bit Score: 58.89  E-value: 2.31e-10
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 502923448 112 EALAERVKPGMRVLDLGTGSGILAIAAQMLGAWAV-GVDNDPAVIPQARHNAAANGVS 168
Cdd:COG4076   27 AAIERVVKPGDVVLDIGTGSGLLSMLAARAGAKKVyAVEVNPDIAAVARRIIAANGLS 84
arsM PRK11873
arsenite methyltransferase;
113-189 2.54e-10

arsenite methyltransferase;


Pssm-ID: 237007 [Multi-domain]  Cd Length: 272  Bit Score: 59.19  E-value: 2.54e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502923448 113 ALAErVKPGMRVLDLGTGSGILA-IAAQMLGA--WAVGVDNDPAVIPQARHNAAANGVSP-EFFLGTLEN---AHGVFDL 185
Cdd:PRK11873  71 ALAE-LKPGETVLDLGSGGGFDCfLAARRVGPtgKVIGVDMTPEMLAKARANARKAGYTNvEFRLGEIEAlpvADNSVDV 149


                 ....
gi 502923448 186 IVAN 189
Cdd:PRK11873 150 IISN 153
RsmC COG2813
16S rRNA G1207 methylase RsmC [Translation, ribosomal structure and biogenesis]; 16S rRNA ...
 107-189 1.79e-08

16S rRNA G1207 methylase RsmC [Translation, ribosomal structure and biogenesis]; 16S rRNA G1207 methylase RsmC is part of the Pathway/BioSystem: 16S rRNA modification


Pssm-ID: 442062 [Multi-domain]  Cd Length: 191  Bit Score: 52.88  E-value: 1.79e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502923448 107 TRMALEALAErvKPGMRVLDLGTGSGILAIAAQMLGAWA--VGVDNDPAVIPQARHNAAANGVSP-EFFLGT-LEN-AHG 181
Cdd:COG2813   38 TRLLLEHLPE--PLGGRVLDLGCGYGVIGLALAKRNPEArvTLVDVNARAVELARANAAANGLENvEVLWSDgLSGvPDG 115


                 ....*...
gi 502923448 182 VFDLIVAN 189
Cdd:COG2813  116 SFDLILSN 123
PRK07580 PRK07580
Mg-protoporphyrin IX methyl transferase; Validated
 102-188 2.09e-08

Mg-protoporphyrin IX methyl transferase; Validated


Pssm-ID: 236059 [Multi-domain]  Cd Length: 230  Bit Score: 53.30  E-value: 2.09e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502923448 102 GHHETTRMALEALAERVKP-GMRVLDLGTGSGILAIAAQMLGAWAVGVDNDPAVIPQARHNAAANGVS--PEFFLGTLEN 178
Cdd:PRK07580  44 GHQRMRDTVLSWLPADGDLtGLRILDAGCGVGSLSIPLARRGAKVVASDISPQMVEEARERAPEAGLAgnITFEVGDLES 123

                         90
                 ....*....|
gi 502923448 179 AHGVFDLIVA 188
Cdd:PRK07580 124 LLGRFDTVVC 133
Methyltransf_31 pfam13847
Methyltransferase domain; This family appears to have methyltransferase activity.
 119-189 3.08e-08

Methyltransferase domain; This family appears to have methyltransferase activity.


Pssm-ID: 463998 [Multi-domain]  Cd Length: 150  Bit Score: 51.65  E-value: 3.08e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502923448  119 KPGMRVLDLGTGSGILAI-AAQMLGAWA--VGVDNDPAVIPQARHNAAANGVSP-EFFLGTLEN-----AHGVFDLIVAN 189
Cdd:pfam13847   2 DKGMRVLDLGCGTGHLSFeLAEELGPNAevVGIDISEEAIEKARENAQKLGFDNvEFEQGDIEElpellEDDKFDVVISN 81
Tam COG4106
Trans-aconitate methyltransferase [Energy production and conversion];
120-215 4.62e-08

Trans-aconitate methyltransferase [Energy production and conversion];


Pssm-ID: 443282 [Multi-domain]  Cd Length: 100  Bit Score: 49.82  E-value: 4.62e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502923448 120 PGMRVLDLGTGSGIL--AIAAQMLGAWAVGVDNDPAVIPQARHNAAanGVspEFFLGTLEN--AHGVFDLIVANL---YA 192
Cdd:COG4106    1 PPRRVLDLGCGTGRLtaLLAERFPGARVTGVDLSPEMLARARARLP--NV--RFVVADLRDldPPEPFDLVVSNAalhWL 76

                         90       100
                 ....*....|....*....|...
gi 502923448 193 ELHAELAPLYPTYLVQGGHMLMT 215
Cdd:COG4106   77 PDHAALLARLAAALAPGGVLAVQ 99
Methyltransf_23 pfam13489
Methyltransferase domain; This family appears to be a methyltransferase domain.
 110-249 4.90e-08

Methyltransferase domain; This family appears to be a methyltransferase domain.


Pssm-ID: 404385 [Multi-domain]  Cd Length: 162  Bit Score: 51.27  E-value: 4.90e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502923448  110 ALEALAERVKPGMRVLDLGTGSGILAIAAQMLGAWAVGVDNDPAVIPQARHNAAANGVSPEFflgtLENAHGVFDLIVAN 189
Cdd:pfam13489  12 LLLRLLPKLPSPGRVLDFGCGTGIFLRLLRAQGFSVTGVDPSPIAIERALLNVRFDQFDEQE----AAVPAGKFDVIVAR 87

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 502923448  190 LYAE----LHAELAPLYpTYLVQGGHMLmtgiLSERERLVDNAMRAQGFESLhrRPEGEWVHLI 249
Cdd:pfam13489  88 EVLEhvpdPPALLRQIA-ALLKPGGLLL----LSTPLASDEADRLLLEWPYL--RPRNGHISLF 144
TrmA COG2265
tRNA/tmRNA/rRNA uracil-C5-methylase, TrmA/RlmC/RlmD family [Translation, ribosomal structure ...
 106-207 6.01e-08

tRNA/tmRNA/rRNA uracil-C5-methylase, TrmA/RlmC/RlmD family [Translation, ribosomal structure and biogenesis]; tRNA/tmRNA/rRNA uracil-C5-methylase, TrmA/RlmC/RlmD family is part of the Pathway/BioSystem: tRNA modification


Pssm-ID: 441866 [Multi-domain]  Cd Length: 377  Bit Score: 52.49  E-value: 6.01e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502923448 106 TTRMALEALAERV------KPGMRVLDLGTGSGILAIAAQMLGAWAVGVDNDPAVIPQARHNAAANGVSP-EFFLGTLEN 178
Cdd:COG2265  213 VNPEQAEALYAAAlewldlTGGERVLDLYCGVGTFALPLARRAKKVIGVEIVPEAVEDARENARLNGLKNvEFVAGDLEE 292

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|
gi 502923448 179 ------AHGVFDLIVAN-----LYAELHAELAPLYPTYLV 207
Cdd:COG2265  293 vlpellWGGRPDVVVLDppragAGPEVLEALAALGPRRIV 332
AdoMet_MTases cd02440
S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; ...
 123-215 3.49e-07

S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). There are at least five structurally distinct families of AdoMet-MTases, class I being the largest and most diverse. Within this class enzymes can be classified by different substrate specificities (small molecules, lipids, nucleic acids, etc.) and different target atoms for methylation (nitrogen, oxygen, carbon, sulfur, etc.).


Pssm-ID: 100107 [Multi-domain]  Cd Length: 107  Bit Score: 47.42  E-value: 3.49e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502923448 123 RVLDLGTGSGILAIAAQMLGAWAV-GVDNDPAVIPQARHNAAANGVSP-EFFLGTLENAHGV----FDLIVANL----YA 192
Cdd:cd02440    1 RVLDLGCGTGALALALASGPGARVtGVDISPVALELARKAAAALLADNvEVLKGDAEELPPEadesFDVIISDPplhhLV 80

                         90       100
                 ....*....|....*....|...
gi 502923448 193 ELHAELAPLYPTYLVQGGHMLMT 215
Cdd:cd02440   81 EDLARFLEEARRLLKPGGVLVLT 103
Pcm COG2518
Protein-L-isoaspartate O-methyltransferase [Posttranslational modification, protein turnover, ...
 108-189 5.27e-07

Protein-L-isoaspartate O-methyltransferase [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 442008 [Multi-domain]  Cd Length: 197  Bit Score: 48.55  E-value: 5.27e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502923448 108 RMaLEALAerVKPGMRVLDLGTGSGIL-AIAAQmLGAWAVGVDNDPAVIPQARHNAAANGVS-PEFFLGTLEN---AHGV 182
Cdd:COG2518   57 RM-LEALD--LKPGDRVLEIGTGSGYQaAVLAR-LAGRVYSVERDPELAERARERLAALGYDnVTVRVGDGALgwpEHAP 132


                 ....*..
gi 502923448 183 FDLIVAN 189
Cdd:COG2518  133 FDRIIVT 139
Trm11 COG1041
tRNA G10 N-methylase Trm11 [Translation, ribosomal structure and biogenesis]; tRNA G10 ...
 117-191 1.15e-06

tRNA G10 N-methylase Trm11 [Translation, ribosomal structure and biogenesis]; tRNA G10 N-methylase Trm11 is part of the Pathway/BioSystem: tRNA modification


Pssm-ID: 440663 [Multi-domain]  Cd Length: 172  Bit Score: 47.25  E-value: 1.15e-06
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 502923448 117 RVKPGMRVLDLGTGSGILAIAAQMLGAWAVGVDNDPAVIPQARHNAAANGV-SPEFFLG---TLENAHGVFDLIVANLY 191
Cdd:COG1041   23 GAKEGDTVLDPFCGTGTILIEAGLLGRRVIGSDIDPKMVEGARENLEHYGYeDADVIRGdarDLPLADESVDAIVTDPP 101
PCMT pfam01135
Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT);
109-161 1.83e-06

Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT);


Pssm-ID: 395902 [Multi-domain]  Cd Length: 205  Bit Score: 47.36  E-value: 1.83e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 502923448  109 MALEALaeRVKPGMRVLDLGTGSGIL-AIAAQMLGA--WAVGVDNDPAVIPQARHN 161
Cdd:pfam01135  64 MMLELL--ELKPGMRVLEIGSGSGYLtACFARMVGEvgRVVSIEHIPELVEIARRN 117
PRK08317 PRK08317
hypothetical protein; Provisional
 108-188 5.79e-06

hypothetical protein; Provisional


Pssm-ID: 181382 [Multi-domain]  Cd Length: 241  Bit Score: 46.08  E-value: 5.79e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502923448 108 RMALEALAerVKPGMRVLDLGTGSGILAIA-AQMLGA--WAVGVDNDPAVIPQARHNAAANGVSPEFFLG---TLENAHG 181
Cdd:PRK08317   9 ARTFELLA--VQPGDRVLDVGCGPGNDARElARRVGPegRVVGIDRSEAMLALAKERAAGLGPNVEFVRGdadGLPFPDG 86


                 ....*..
gi 502923448 182 VFDLIVA 188
Cdd:PRK08317  87 SFDAVRS 93
COG4976 COG4976
Predicted methyltransferase, contains TPR repeat [General function prediction only];
102-189 7.46e-06

Predicted methyltransferase, contains TPR repeat [General function prediction only];


Pssm-ID: 444001 [Multi-domain]  Cd Length: 181  Bit Score: 44.99  E-value: 7.46e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502923448 102 GHHETTRMALEALAERvkPGMRVLDLGTGSGILAIAAQMLGAWAVGVDNDPAVIPQARhnaaANGVSPEFF---LGTLEN 178
Cdd:COG4976   30 APALLAEELLARLPPG--PFGRVLDLGCGTGLLGEALRPRGYRLTGVDLSEEMLAKAR----EKGVYDRLLvadLADLAE 103

                         90
                 ....*....|.
gi 502923448 179 AHGVFDLIVAN 189
Cdd:COG4976  104 PDGRFDLIVAA 114
Methyltransf_11 pfam08241
Methyltransferase domain; Members of this family are SAM dependent methyltransferases.
 125-190 8.72e-06

Methyltransferase domain; Members of this family are SAM dependent methyltransferases.


Pssm-ID: 462406 [Multi-domain]  Cd Length: 94  Bit Score: 43.04  E-value: 8.72e-06
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 502923448  125 LDLGTGSGILAIAAQMLGAWAVGVDNDPAVIPQARHNAAANGVspEFFLGTLEN---AHGVFDLIVANL 190
Cdd:pfam08241   1 LDVGCGTGLLTELLARLGARVTGVDISPEMLELAREKAPREGL--TFVVGDAEDlpfPDNSFDLVLSSE 67
PRK14966 PRK14966
unknown domain/N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase fusion protein; ...
 41-189 1.93e-05

unknown domain/N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase fusion protein; Provisional


Pssm-ID: 184930 [Multi-domain]  Cd Length: 423  Bit Score: 45.07  E-value: 1.93e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502923448  41 TRLELPLPGEwAELPDTDWLEAWRRDLKPVRAGPFVVLAPWHRWEGpeQRILLEPGMAFGtghHETTRMALEALAERVKP 120
Cdd:PRK14966 178 TRVQLLTRGG-EEMPDEVRQRADRLAQRRLNGEPVAYILGVREFYG--RRFAVNPNVLIP---RPETEHLVEAVLARLPE 251

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 502923448 121 GMRVLDLGTGSGILA--IAAQMLGAWAVGVDNDPAVIPQARHNAAANGVSPEFFLGTLEN----AHGVFDLIVAN 189
Cdd:PRK14966 252 NGRVWDLGTGSGAVAvtVALERPDAFVRASDISPPALETARKNAADLGARVEFAHGSWFDtdmpSEGKWDIIVSN 326
MTS pfam05175
Methyltransferase small domain; This domain is found in ribosomal RNA small subunit ...
 107-214 3.61e-05

Methyltransferase small domain; This domain is found in ribosomal RNA small subunit methyltransferase C as well as other methyltransferases.


Pssm-ID: 428349 [Multi-domain]  Cd Length: 170  Bit Score: 42.96  E-value: 3.61e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502923448  107 TRMALEALAERvkPGMRVLDLGTGSGILAIA-AQMLG-AWAVGVDNDPAVIPQARHNAAANGVSP-EFFLGTLENA--HG 181
Cdd:pfam05175  20 SRLLLEHLPKD--LSGKVLDLGCGAGVLGAAlAKESPdAELTMVDINARALESARENLAANGLENgEVVASDVYSGveDG 97

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|...
gi 502923448  182 VFDLIVANlyAELHAELAPLY----------PTYLVQGGHMLM 214
Cdd:pfam05175  98 KFDLIISN--PPFHAGLATTYnvaqrfiadaKRHLRPGGELWI 138
Gcd14 COG2519
tRNA A58 N-methylase Trm61 [Translation, ribosomal structure and biogenesis]; tRNA A58 ...
 118-240 6.87e-05

tRNA A58 N-methylase Trm61 [Translation, ribosomal structure and biogenesis]; tRNA A58 N-methylase Trm61 is part of the Pathway/BioSystem: tRNA modification


Pssm-ID: 442009 [Multi-domain]  Cd Length: 249  Bit Score: 42.84  E-value: 6.87e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502923448 118 VKPGMRVLDLGTGSGILAIAaqmLgAWAVG-------VDNDPAVIPQARHNAAANGVSP--EFFLGTLENA--HGVFDLI 186
Cdd:COG2519   89 IFPGARVLEAGTGSGALTLA---L-ARAVGpegkvysYERREDFAEIARKNLERFGLPDnvELKLGDIREGidEGDVDAV 164

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 502923448 187 VANLyaelhaeLAP------LYPTyLVQGGHML-----MTGIlserERLVDnAMRAQGF------ESLHRR 240
Cdd:COG2519  165 FLDM-------PDPwealeaVAKA-LKPGGVLVayvptVNQV----SKLVE-ALRESGFtdieavETLLRE 222
Trm5 COG2520
tRNA G37 N-methylase Trm5 [Translation, ribosomal structure and biogenesis]; tRNA G37 ...
 115-191 1.05e-04

tRNA G37 N-methylase Trm5 [Translation, ribosomal structure and biogenesis]; tRNA G37 N-methylase Trm5 is part of the Pathway/BioSystem: tRNA modification


Pssm-ID: 442010 [Multi-domain]  Cd Length: 333  Bit Score: 42.54  E-value: 1.05e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502923448 115 AERVKPGMRVLDLGTGSGILAI-AAQMLGAWAVGVDNDPAVIPQARHNAAANGVS--PEFFLG----TLENAHGVFDLIV 187
Cdd:COG2520  175 AELVKPGERVLDMFAGVGPFSIpIAKRSGAKVVAIDINPDAVEYLKENIRLNKVEdrVTPILGdareVAPELEGKADRII 254


                 ....
gi 502923448 188 ANLY 191
Cdd:COG2520  255 MNLP 258
YtxK COG0827
Adenine-specific DNA N6-methylase [Replication, recombination and repair];
121-190 1.25e-04

Adenine-specific DNA N6-methylase [Replication, recombination and repair];


Pssm-ID: 440589 [Multi-domain]  Cd Length: 327  Bit Score: 42.63  E-value: 1.25e-04
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 502923448 121 GMRVLDLGTGSGIL--AIAAQMLG-AWAVGVDNDPAVIPQARHNAAANGVSPEFFLGTLENAHGV--FDLIVANL 190
Cdd:COG0827  116 GLRILDPAVGTGNLltTVLNQLKKkVNAYGVEVDDLLIRLAAVLANLQGHPVELFHQDALQPLLIdpVDVVISDL 190
rumA PRK13168
23S rRNA (uracil(1939)-C(5))-methyltransferase RlmD;
110-172 1.42e-04

23S rRNA (uracil(1939)-C(5))-methyltransferase RlmD;


Pssm-ID: 237291 [Multi-domain]  Cd Length: 443  Bit Score: 42.45  E-value: 1.42e-04
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 502923448 110 ALEALAerVKPGMRVLDL--GTGSGILAIAAQmlGAWAVGVDNDPAVIPQARHNAAANGVS-PEFF 172
Cdd:PRK13168 289 ALEWLD--PQPGDRVLDLfcGLGNFTLPLARQ--AAEVVGVEGVEAMVERARENARRNGLDnVTFY 350
RlmK COG1092
23S rRNA G2069 N7-methylase RlmK or C1962 C5-methylase RlmI [Translation, ribosomal structure ...
 85-187 2.80e-04

23S rRNA G2069 N7-methylase RlmK or C1962 C5-methylase RlmI [Translation, ribosomal structure and biogenesis]; 23S rRNA G2069 N7-methylase RlmK or C1962 C5-methylase RlmI is part of the Pathway/BioSystem: 23S rRNA modification


Pssm-ID: 440709 [Multi-domain]  Cd Length: 392  Bit Score: 41.71  E-value: 2.80e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502923448  85 EGPEQRILLEPGMAFG--------TGH---HETTRMALEALAErvkpGMRVLDL--GTGSgiLAIAAQMLGAWAV-GVDN 150
Cdd:COG1092  174 EAPEEVEVEENGLKFLvdltdgqkTGLfldQRENRARVAELAK----GKRVLNLfsYTGG--FSVHAAAGGAKSVtSVDL 247

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*.
gi 502923448 151 DPAVIPQARHNAAANGVSPEF---------FLGTLENAHGVFDLIV 187
Cdd:COG1092  248 SATALEWAKENAALNGLDDRHefvqadafdWLRELAREGERFDLII 293
ubiE PRK00216
bifunctional demethylmenaquinone methyltransferase/2-methoxy-6-polyprenyl-1,4-benzoquinol ...
 97-149 4.65e-04

bifunctional demethylmenaquinone methyltransferase/2-methoxy-6-polyprenyl-1,4-benzoquinol methylase UbiE;


Pssm-ID: 234689 [Multi-domain]  Cd Length: 239  Bit Score: 40.52  E-value: 4.65e-04
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 502923448  97 MAFGTgHHETTRMALEALaeRVKPGMRVLDLGTGSGILAIA-AQMLG--AWAVGVD 149
Cdd:PRK00216  31 LSFGL-HRVWRRKTIKWL--GVRPGDKVLDLACGTGDLAIAlAKAVGktGEVVGLD 83
COG2521 COG2521
Predicted archaeal methyltransferase [General function prediction only];
117-186 1.15e-03

Predicted archaeal methyltransferase [General function prediction only];


Pssm-ID: 442011 [Multi-domain]  Cd Length: 285  Bit Score: 39.51  E-value: 1.15e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 502923448 117 RVKPGMRVLDLGTGSGILAIAAQMLGAWAV-GVDNDPAVIPQARHNAAangvSPEFFLGTLENAHG-VFDLI 186
Cdd:COG2521  129 GVRRGDRVLDTCTGLGYTAIEALKRGAREViTVEKDPNVLELAELNPW----SRELANERIKIILGdASEVI 196
PRK06202 PRK06202
hypothetical protein; Provisional
 111-192 1.30e-03

hypothetical protein; Provisional


Pssm-ID: 180466 [Multi-domain]  Cd Length: 232  Bit Score: 39.21  E-value: 1.30e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502923448 111 LEALAERVKPGMRVLDLGTGSGILAIAaqmLGAWA---------VGVDNDPAVIPQARHNAAANGVSPEFFL-GTLENAH 180
Cdd:PRK06202  51 LLRPALSADRPLTLLDIGCGGGDLAID---LARWArrdglrlevTAIDPDPRAVAFARANPRRPGVTFRQAVsDELVAEG 127

                         90
                 ....*....|..
gi 502923448 181 GVFDLIVANLYA 192
Cdd:PRK06202 128 ERFDVVTSNHFL 139
RsmD COG0742
16S rRNA G966 N2-methylase RsmD [Translation, ribosomal structure and biogenesis]; 16S rRNA ...
 120-186 3.34e-03

16S rRNA G966 N2-methylase RsmD [Translation, ribosomal structure and biogenesis]; 16S rRNA G966 N2-methylase RsmD is part of the Pathway/BioSystem: 16S rRNA modification


Pssm-ID: 440505 [Multi-domain]  Cd Length: 183  Bit Score: 37.37  E-value: 3.34e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 502923448 120 PGMRVLDLGTGSGILAIAAqmL--GA-WAVGVDNDPAVIPQARHNAAANGVSPEF---------FLGTLenAHGVFDLI 186
Cdd:COG0742   41 EGARVLDLFAGSGALGLEA--LsrGAaSVVFVEKDRKAAAVIRKNLEKLGLEDRArvirgdalrFLKRL--AGEPFDLV 115
hemK_fam TIGR00536
HemK family putative methylases; The gene hemK from E. coli was found to contribute to heme ...
 110-189 3.39e-03

HemK family putative methylases; The gene hemK from E. coli was found to contribute to heme biosynthesis and originally suggested to be protoporphyrinogen oxidase. Functional analysis of the nearest homolog in Saccharomyces cerevisiae, YNL063w, finds it is not protoporphyrinogen oxidase and sequence analysis suggests that HemK homologs have S-adenosyl-methionine-dependent methyltransferase activity (Medline 99237242). Homologs are found, usually in a single copy, in nearly all completed genomes, but varying somewhat in apparent domain architecture. Both E. coli and H. influenzae have two members rather than one. The members from the Mycoplasmas have an additional C-terminal domain. [Protein fate, Protein modification and repair]


Pssm-ID: 273125 [Multi-domain]  Cd Length: 284  Bit Score: 38.10  E-value: 3.39e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502923448  110 ALEALAERvKPGMRVLDLGTGSGI--LAIAAQMLGAWAVGVDNDPAVIPQARHNAAANGVSPE-FFLGT--LEN-AHGVF 183
Cdd:TIGR00536 105 ALASLISQ-PPILHILDLGTGSGCiaLALAYEFPNAEVIAVDISPDALAVAEENAEKNQLEHRvEFIQSnlFEPlAGQKI 183


                  ....*.
gi 502923448  184 DLIVAN 189
Cdd:TIGR00536 184 DIIVSN 189
BioC TIGR02072
malonyl-acyl carrier protein O-methyltransferase BioC; This enzyme, which is found in biotin ...
 123-190 5.93e-03

malonyl-acyl carrier protein O-methyltransferase BioC; This enzyme, which is found in biotin biosynthetic gene clusters in proteobacteria, firmicutes, green-sulfur bacteria, fusobacterium and bacteroides, carries out an enzymatic step prior to the formation of pimeloyl-CoA, namely O-methylation of the malonyl group preferentially while on acyl carrier protein. The enzyme is recognizable as a methyltransferase by homology. [Biosynthesis of cofactors, prosthetic groups, and carriers, Biotin]


Pssm-ID: 273953 [Multi-domain]  Cd Length: 240  Bit Score: 37.27  E-value: 5.93e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 502923448  123 RVLDLGTGSGIL--AIAAQMLGAWAVGVDNDPAVIPQARHNAAANgvsPEFFLGTLEN---AHGVFDLIVANL 190
Cdd:TIGR02072  37 SVLDIGCGTGYLtrALLKRFPQAEFIALDISAGMLAQAKTKLSEN---VQFICGDAEKlplEDSSFDLIVSNL 106
UPF0020 pfam01170
Putative RNA methylase family UPF0020; This domain is probably a methylase. It is associated ...
 117-189 6.35e-03

Putative RNA methylase family UPF0020; This domain is probably a methylase. It is associated with the THUMP domain that also occurs with RNA modification domains.


Pssm-ID: 395932 [Multi-domain]  Cd Length: 184  Bit Score: 36.56  E-value: 6.35e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502923448  117 RVKPGMRVLDLGTGSGILAIAAQMLGAWA-------------VGVDNDPAVIPQARHNAAANGVSPEFFLGT-----LEN 178
Cdd:pfam01170  25 GWKPGDPLLDPMCGSGTILIEAALMGANIapgkfdarvraplYGSDIDRRMVQGARLNAENAGVGDLIEFVQadaadLPL 104

                          90
                  ....*....|.
gi 502923448  179 AHGVFDLIVAN 189
Cdd:pfam01170 105 LEGSVDVIVTN 115
CMAS pfam02353
Mycolic acid cyclopropane synthetase; This family consist of ...
 108-148 7.12e-03

Mycolic acid cyclopropane synthetase; This family consist of Cyclopropane-fatty-acyl-phospholipid synthase or CFA synthase EC:2.1.1.79 this enzyme catalyze the reaction: S-adenosyl-L-methionine + phospholipid olefinic fatty acid <=> S-adenosyl-L-homocysteine + phospholipid cyclopropane fatty acid.


Pssm-ID: 396777 [Multi-domain]  Cd Length: 272  Bit Score: 36.92  E-value: 7.12e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 502923448  108 RMALEALaeRVKPGMRVLDLGTGSGILAI-AAQMLGAWAVGV 148
Cdd:pfam02353  51 DLILDKL--GLKPGMTLLDIGCGWGGLMRrAAERYDVNVVGL 90
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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