NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|502936665|ref|WP_013171641|]
View 

transglutaminase domain-containing protein [Salisediminibacterium selenitireducens]

Protein Classification

DUF4129 domain-containing transglutaminase family protein( domain architecture ID 11442004)

DUF4129 domain-containing transglutaminase family protein may be a cysteine protease with conserved cysteine, histidine, and aspartate residues that form the catalytic triad

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
YebA COG1305
Transglutaminase-like enzyme, putative cysteine protease [Posttranslational modification, ...
 425-569 5.58e-31

Transglutaminase-like enzyme, putative cysteine protease [Posttranslational modification, protein turnover, chaperones];


:

Pssm-ID: 440916 [Multi-domain]  Cd Length: 174  Bit Score: 119.34  E-value: 5.58e-31
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502936665 425 DPQALFERYTQLPDDLPERVIDLAFEITEEEDNRYDKAVAVEQYFgQNDFVYqttDVPVPEEGQDYVDQFlfETQAGYCD 504
Cdd:COG1305   44 GTELLAGPGELLSASYDPELRALAAELTGGATTPYEKARALYDWV-RDNIRY---DPGSTGVGTTALETL--ERRRGVCR 117

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 502936665 505 NYSTSMVVLLRALDIPARWVKGFTSGEQTEVLDDgrsvyevsNTNAHSWVEVYFPEVGWVPFEPT 569
Cdd:COG1305  118 DFAHLLVALLRALGIPARYVSGYLPGEPPPGGGR--------ADDAHAWVEVYLPGAGWVPFDPT 174
DUF4129 pfam13559
Domain of unknown function (DUF4129); This presumed domain is found at the C-terminus of ...
 685-751 2.05e-14

Domain of unknown function (DUF4129); This presumed domain is found at the C-terminus of proteins that contain a transglutaminase core domain. The function of this domain is unknown. The domain has a conserved TXXE motif.


:

Pssm-ID: 433308  Cd Length: 70  Bit Score: 68.34  E-value: 2.05e-14
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502936665  685 AYRRLLWLLEKEGLPRGEGETLREYARRADQAFSSQA--MSKLTKAYERIYYGGFDPD-GDWQKHRKDWE 751
Cdd:pfam13559   1 AYRALLRLLARRGLPRRPSETPREYARRLARALPALAaaLRRLTRLYERARYGGRPVTaEDLRRARAALR 70
 
Name Accession Description Interval E-value
YebA COG1305
Transglutaminase-like enzyme, putative cysteine protease [Posttranslational modification, ...
 425-569 5.58e-31

Transglutaminase-like enzyme, putative cysteine protease [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 440916 [Multi-domain]  Cd Length: 174  Bit Score: 119.34  E-value: 5.58e-31
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502936665 425 DPQALFERYTQLPDDLPERVIDLAFEITEEEDNRYDKAVAVEQYFgQNDFVYqttDVPVPEEGQDYVDQFlfETQAGYCD 504
Cdd:COG1305   44 GTELLAGPGELLSASYDPELRALAAELTGGATTPYEKARALYDWV-RDNIRY---DPGSTGVGTTALETL--ERRRGVCR 117

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 502936665 505 NYSTSMVVLLRALDIPARWVKGFTSGEQTEVLDDgrsvyevsNTNAHSWVEVYFPEVGWVPFEPT 569
Cdd:COG1305  118 DFAHLLVALLRALGIPARYVSGYLPGEPPPGGGR--------ADDAHAWVEVYLPGAGWVPFDPT 174
Transglut_core pfam01841
Transglutaminase-like superfamily; This family includes animal transglutaminases and other ...
 445-568 1.29e-25

Transglutaminase-like superfamily; This family includes animal transglutaminases and other bacterial proteins of unknown function. Sequence conservation in this superfamily primarily involves three motifs that centre around conserved cysteine, histidine, and aspartate residues that form the catalytic triad in the structurally characterized transglutaminase, the human blood clotting factor XIIIa'. On the basis of the experimentally demonstrated activity of the Methanobacterium phage pseudomurein endoisopeptidase, it is proposed that many, if not all, microbial homologs of the transglutaminases are proteases and that the eukaryotic transglutaminases have evolved from an ancestral protease.


Pssm-ID: 376628 [Multi-domain]  Cd Length: 108  Bit Score: 101.71  E-value: 1.29e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502936665  445 IDLAFEITEEEDNRYDKAVAVEQYFgQNDFVYqttDVPVPEEGQDYVDQFLFeTQAGYCDNYSTSMVVLLRALDIPARWV 524
Cdd:pfam01841   1 KALADRITGGATDPLEKARAIYDYV-RKNITY---DLPGRSPGDGDAEEFLF-TGKGDCEDFASLFVALLRALGIPARYV 75

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....
gi 502936665  525 KGFTSGEQTevlddgrsvyeVSNTNAHSWVEVYFPEVGWVPFEP 568
Cdd:pfam01841  76 TGYLRGPDT-----------VRGGDAHAWVEVYLPGYGWVPVDP 108
TGc smart00460
Transglutaminase/protease-like homologues; Transglutaminases are enzymes that establish ...
 495-569 1.07e-16

Transglutaminase/protease-like homologues; Transglutaminases are enzymes that establish covalent links between proteins. A subset of transglutaminase homologues appear to catalyse the reverse reaction, the hydrolysis of peptide bonds. Proteins with this domain are both extracellular and intracellular, and it is likely that the eukaryotic intracellular proteins are involved in signalling events.


Pssm-ID: 214673  Cd Length: 68  Bit Score: 75.11  E-value: 1.07e-16
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 502936665   495 LFETQAGYCDNYSTSMVVLLRALDIPARWVKGFTSGEQTEVLDdgrsvyeVSNTNAHSWVEVYFPeVGWVPFEPT 569
Cdd:smart00460   1 LLKTKYGTCGEFAALFVALLRSLGIPARVVSGYLKAPDTIGGL-------RSIWEAHAWAEVYLE-GGWVPVDPT 67
DUF4129 pfam13559
Domain of unknown function (DUF4129); This presumed domain is found at the C-terminus of ...
 685-751 2.05e-14

Domain of unknown function (DUF4129); This presumed domain is found at the C-terminus of proteins that contain a transglutaminase core domain. The function of this domain is unknown. The domain has a conserved TXXE motif.


Pssm-ID: 433308  Cd Length: 70  Bit Score: 68.34  E-value: 2.05e-14
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502936665  685 AYRRLLWLLEKEGLPRGEGETLREYARRADQAFSSQA--MSKLTKAYERIYYGGFDPD-GDWQKHRKDWE 751
Cdd:pfam13559   1 AYRALLRLLARRGLPRRPSETPREYARRLARALPALAaaLRRLTRLYERARYGGRPVTaEDLRRARAALR 70
 
Name Accession Description Interval E-value
YebA COG1305
Transglutaminase-like enzyme, putative cysteine protease [Posttranslational modification, ...
 425-569 5.58e-31

Transglutaminase-like enzyme, putative cysteine protease [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 440916 [Multi-domain]  Cd Length: 174  Bit Score: 119.34  E-value: 5.58e-31
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502936665 425 DPQALFERYTQLPDDLPERVIDLAFEITEEEDNRYDKAVAVEQYFgQNDFVYqttDVPVPEEGQDYVDQFlfETQAGYCD 504
Cdd:COG1305   44 GTELLAGPGELLSASYDPELRALAAELTGGATTPYEKARALYDWV-RDNIRY---DPGSTGVGTTALETL--ERRRGVCR 117

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 502936665 505 NYSTSMVVLLRALDIPARWVKGFTSGEQTEVLDDgrsvyevsNTNAHSWVEVYFPEVGWVPFEPT 569
Cdd:COG1305  118 DFAHLLVALLRALGIPARYVSGYLPGEPPPGGGR--------ADDAHAWVEVYLPGAGWVPFDPT 174
Transglut_core pfam01841
Transglutaminase-like superfamily; This family includes animal transglutaminases and other ...
 445-568 1.29e-25

Transglutaminase-like superfamily; This family includes animal transglutaminases and other bacterial proteins of unknown function. Sequence conservation in this superfamily primarily involves three motifs that centre around conserved cysteine, histidine, and aspartate residues that form the catalytic triad in the structurally characterized transglutaminase, the human blood clotting factor XIIIa'. On the basis of the experimentally demonstrated activity of the Methanobacterium phage pseudomurein endoisopeptidase, it is proposed that many, if not all, microbial homologs of the transglutaminases are proteases and that the eukaryotic transglutaminases have evolved from an ancestral protease.


Pssm-ID: 376628 [Multi-domain]  Cd Length: 108  Bit Score: 101.71  E-value: 1.29e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502936665  445 IDLAFEITEEEDNRYDKAVAVEQYFgQNDFVYqttDVPVPEEGQDYVDQFLFeTQAGYCDNYSTSMVVLLRALDIPARWV 524
Cdd:pfam01841   1 KALADRITGGATDPLEKARAIYDYV-RKNITY---DLPGRSPGDGDAEEFLF-TGKGDCEDFASLFVALLRALGIPARYV 75

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....
gi 502936665  525 KGFTSGEQTevlddgrsvyeVSNTNAHSWVEVYFPEVGWVPFEP 568
Cdd:pfam01841  76 TGYLRGPDT-----------VRGGDAHAWVEVYLPGYGWVPVDP 108
TGc smart00460
Transglutaminase/protease-like homologues; Transglutaminases are enzymes that establish ...
 495-569 1.07e-16

Transglutaminase/protease-like homologues; Transglutaminases are enzymes that establish covalent links between proteins. A subset of transglutaminase homologues appear to catalyse the reverse reaction, the hydrolysis of peptide bonds. Proteins with this domain are both extracellular and intracellular, and it is likely that the eukaryotic intracellular proteins are involved in signalling events.


Pssm-ID: 214673  Cd Length: 68  Bit Score: 75.11  E-value: 1.07e-16
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 502936665   495 LFETQAGYCDNYSTSMVVLLRALDIPARWVKGFTSGEQTEVLDdgrsvyeVSNTNAHSWVEVYFPeVGWVPFEPT 569
Cdd:smart00460   1 LLKTKYGTCGEFAALFVALLRSLGIPARVVSGYLKAPDTIGGL-------RSIWEAHAWAEVYLE-GGWVPVDPT 67
DUF4129 pfam13559
Domain of unknown function (DUF4129); This presumed domain is found at the C-terminus of ...
 685-751 2.05e-14

Domain of unknown function (DUF4129); This presumed domain is found at the C-terminus of proteins that contain a transglutaminase core domain. The function of this domain is unknown. The domain has a conserved TXXE motif.


Pssm-ID: 433308  Cd Length: 70  Bit Score: 68.34  E-value: 2.05e-14
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502936665  685 AYRRLLWLLEKEGLPRGEGETLREYARRADQAFSSQA--MSKLTKAYERIYYGGFDPD-GDWQKHRKDWE 751
Cdd:pfam13559   1 AYRALLRLLARRGLPRRPSETPREYARRLARALPALAaaLRRLTRLYERARYGGRPVTaEDLRRARAALR 70
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH