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Conserved domains on  [gi|502954518|ref|WP_013189494|]
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ROK family protein [Mobiluncus curtisii]

Protein Classification

ROK family protein( domain architecture ID 11449187)

ROK (Repressor, ORF, Kinase) family protein functions as a sugar kinase or may act as a transcriptional regulator involved in carbohydrate-dependent transcriptional control

CATH:  3.30.420.40
Gene Ontology:  GO:0005524
PubMed:  20512568|17979299
SCOP:  3000092|4000330

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
ASKHA_ATPase-like super family cl49607
ATPase-like domain of the ASKHA (Acetate and Sugar Kinases/Hsc70/Actin) superfamily; The ASKHA ...
 84-365 5.27e-62

ATPase-like domain of the ASKHA (Acetate and Sugar Kinases/Hsc70/Actin) superfamily; The ASKHA superfamily, also known as actin-like ATPase domain superfamily, includes acetate and sugar kinases, heat-shock cognate 70 (Hsp70) and actin family proteins. They either function as conformational hydrolases (e.g. Hsp70, actin) that perform simple ATP hydrolysis, or as metabolite kinases (e.g. glycerol kinase) that catalyze the transfer of a phosphoryl group from ATP to their cognate substrates. Both activities depend on the presence of specific metal cations. ASKHA superfamily members share a common core fold that includes an actin-like ATPase domain consisting of two subdomains (denoted I _ II) with highly similar ribonuclease (RNase) H-like folds. The fold of each subdomain is characterized by a central five strand beta-sheet and flanking alpha-helices. The two subdomains form an active site cleft in which ATP binds at the bottom. Another common feature of ASKHA superfamily members is the coupling of phosphoryl-group transfer to conformational rearrangement, leading to domain closure. Substrate binding triggers protein motion.


The actual alignment was detected with superfamily member cd24076:

Pssm-ID: 483947 [Multi-domain]  Cd Length: 303  Bit Score: 201.25  E-value: 5.27e-62
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502954518  84 LVSLGVDIGVSWIRMMGLGLGGEELFRKQFELDvPALSSEEVFSLVGNELNLFVSNL-SSRAVIFAVTVSVPGLVDSDNG 162
Cdd:cd24076    1 GAVIGVELGVDYITVVVTDLAGEVLWRREVPLP-ASDDPDEVLAQLAALIREALAAApDSPLGILGIGVGVPGLVDSEDG 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502954518 163 SVIYAPNLDWTNVDVCQQVNRviQFSVKsIEVHNEANMAALAHtwKRPGCPSGLDTFAYISGGVGVGAAVIENRQLYLGR 242
Cdd:cd24076   80 VVLLAPNLGWRDVPLRDLLEE--ALGVP-VFVDNEANAAALAE--KRFGAGRGVSDLVYLSAGVGIGAGIILDGELYRGA 154

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502954518 243 HGWVGEIGHLTIDPRGIQCKCGAQGCLERYVGRQAL-----------------EI----RSGDNAAL--VESA-RALGMA 298
Cdd:cd24076  155 SGFAGEIGHMTVDPDGPPCSCGNRGCWETYASERALlraagrlgaggeplslaELveaaRAGDPAALaaLEEVgEYLGIG 234

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 502954518 299 LAALTNILDVSLIIIGGDVTNLFADYSEEVKRLMRLHTIADEQRSLQITGSAYEM-PAVRGAAIQGFQ 365
Cdd:cd24076  235 LANLVNTFNPELVVLGGALAPLGPWLLPPLRAEVARRALPAPARDVRIVVSRLGEdAAALGAAALAID 302
 
Name Accession Description Interval E-value
ASKHA_ATPase_ROK_BsXylR-like cd24076
ATPase-like domain of Bacillus subtilis xylose repressor (XylR) and similar proteins; This ...
 84-365 5.27e-62

ATPase-like domain of Bacillus subtilis xylose repressor (XylR) and similar proteins; This subfamily includes a group of uncharacterized proteins similar to Bacillus subtilis xylose repressor (BsXylR), which belongs to the kinase (ROK) family, a group of proteins that have sugar kinase and/or transcriptional repressor activities. BsXylR acts as transcriptional repressor of xylose-utilizing enzymes.


Pssm-ID: 466926 [Multi-domain]  Cd Length: 303  Bit Score: 201.25  E-value: 5.27e-62
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502954518  84 LVSLGVDIGVSWIRMMGLGLGGEELFRKQFELDvPALSSEEVFSLVGNELNLFVSNL-SSRAVIFAVTVSVPGLVDSDNG 162
Cdd:cd24076    1 GAVIGVELGVDYITVVVTDLAGEVLWRREVPLP-ASDDPDEVLAQLAALIREALAAApDSPLGILGIGVGVPGLVDSEDG 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502954518 163 SVIYAPNLDWTNVDVCQQVNRviQFSVKsIEVHNEANMAALAHtwKRPGCPSGLDTFAYISGGVGVGAAVIENRQLYLGR 242
Cdd:cd24076   80 VVLLAPNLGWRDVPLRDLLEE--ALGVP-VFVDNEANAAALAE--KRFGAGRGVSDLVYLSAGVGIGAGIILDGELYRGA 154

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502954518 243 HGWVGEIGHLTIDPRGIQCKCGAQGCLERYVGRQAL-----------------EI----RSGDNAAL--VESA-RALGMA 298
Cdd:cd24076  155 SGFAGEIGHMTVDPDGPPCSCGNRGCWETYASERALlraagrlgaggeplslaELveaaRAGDPAALaaLEEVgEYLGIG 234

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 502954518 299 LAALTNILDVSLIIIGGDVTNLFADYSEEVKRLMRLHTIADEQRSLQITGSAYEM-PAVRGAAIQGFQ 365
Cdd:cd24076  235 LANLVNTFNPELVVLGGALAPLGPWLLPPLRAEVARRALPAPARDVRIVVSRLGEdAAALGAAALAID 302
NagC COG1940
Sugar kinase of the NBD/HSP70 family, may contain an N-terminal HTH domain [Carbohydrate ...
 85-365 4.28e-61

Sugar kinase of the NBD/HSP70 family, may contain an N-terminal HTH domain [Carbohydrate transport and metabolism, Transcription];


Pssm-ID: 441543 [Multi-domain]  Cd Length: 306  Bit Score: 198.97  E-value: 4.28e-61
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502954518  85 VSLGVDIGVSWIRMMGLGLGGEELFRKQFELDVPAlSSEEVFSLVGNELNLFVSNLS-SRAVIFAVTVSVPGLVDSDNGS 163
Cdd:COG1940    6 YVIGIDIGGTKIKAALVDLDGEVLARERIPTPAGA-GPEAVLEAIAELIEELLAEAGiSRGRILGIGIGVPGPVDPETGV 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502954518 164 VIYAPNL-DWTNVDVCQQVNRVIQFSVksiEVHNEANMAALAHTWKrpGCPSGLDTFAYISGGVGVGAAVIENRQLYLGR 242
Cdd:COG1940   85 VLNAPNLpGWRGVPLAELLEERLGLPV---FVENDANAAALAEAWF--GAGRGADNVVYLTLGTGIGGGIVINGKLLRGA 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502954518 243 HGWVGEIGHLTIDPRGIQCKCGAQGCLERYVGRQALE--------------------IRSGDNAA---LVESARALGMAL 299
Cdd:COG1940  160 NGNAGEIGHMPVDPDGPLCGCGNRGCLETYASGPALLrrarelggaekltaeelfaaARAGDPLAlevLDEAARYLGIGL 239

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 502954518 300 AALTNILDVSLIIIGGDVTNLFADYSEEVKRLMRLHTIADEQRSLQITGSAY-EMPAVRGAAIQGFQ 365
Cdd:COG1940  240 ANLINLLDPEVIVLGGGVSAAGDLLLEPIREALAKYALPPAREDPRIVPASLgDDAGLLGAAALALE 306
ROK pfam00480
ROK family; This family, known as ROK (Repressor, ORF, Kinase) includes the xylose operon ...
 87-319 1.27e-33

ROK family; This family, known as ROK (Repressor, ORF, Kinase) includes the xylose operon repressor, xylR, from Bacillus subtilis, Lactobacillus pentosus and Staphylococcus xylosus; N-acetylglucosamine repressor, nagC, from Escherichia coli; glucokinase from Streptomyces coelicolor; fructokinase from from Pediococcus pentosaceus, Streptococcus mutans and Zymomonas mobilis; allokinase and mlc from E. coli; and E. coli hypothetical proteins yajF and yhcI and the corresponding Haemophilus influenzae proteins. The repressor proteins (xylR and nagC) from this family possess an N-terminal region not present in the sugar kinases and which contains an helix-turn-helix DNA-binding motif.


Pssm-ID: 395384 [Multi-domain]  Cd Length: 292  Bit Score: 126.69  E-value: 1.27e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502954518   87 LGVDIGVSWIRMMGLGLGGEELFRKQFEldVPALSSEEVfslVGNELNLFVSNLSSRA-VIFAVTVSVPGLVDSDNGSVI 165
Cdd:pfam00480   1 IGIDIGGTKIAAALFDEEGEILARERVP--TPTTTTEET---LVDAIAFFVDSAQRKFgELIAVGIGSPGLISPKYGYIT 75

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502954518  166 YAPNLDWTNVDVC----QQVNRviqfsvkSIEVHNEANMAALAHTWKrpGCPSGLDTFAYISGGVGVGAAVIENRQLYLG 241
Cdd:pfam00480  76 NTPNIGWDNFDLVekleERFNV-------PVFFENDANAAALAEAVF--GASKDVQNVIYVTVGTGVGGGVISNGKLFTG 146

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502954518  242 RHGWVGEIGHLTIDPRGIQCKCGAQGCLERYVGRQALEIRSGD---------------------NAALVESARALGMALA 300
Cdd:pfam00480 147 RNGVAGEIGHIQLDPNGPKCGCGNHGCLETIASGRALEKRYQQkgedlegkdiivlaeqgdevaEEAVERLARYLAKAIA 226

                         250
                  ....*....|....*....
gi 502954518  301 ALTNILDVSLIIIGGDVTN 319
Cdd:pfam00480 227 NLINLFDPQAIVLGGGVSN 245
ROK_glcA_fam TIGR00744
ROK family protein (putative glucokinase); This model models one branch of the ROK superfamily ...
 87-318 2.32e-22

ROK family protein (putative glucokinase); This model models one branch of the ROK superfamily of proteins. The three members of the seed alignment for this model all have experimental evidence for activity as glucokinase, but the set of related proteins is crowded with paralogs of different or unknown function. Proteins scoring above the trusted_cutoff will show strong similarity to at least one known glucokinase and may be designated as putative glucokinases. However, definitive identification of glucokinases should be done only with extreme caution. [Unknown function, General]


Pssm-ID: 273246 [Multi-domain]  Cd Length: 318  Bit Score: 96.12  E-value: 2.32e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502954518   87 LGVDIGVSWIRmmgLGLGGEELFR-KQFELDVPAlSSEEVFSLVGNELNLFVSNLS-SRAVIFAVTVSVPGLVDSDNGSV 164
Cdd:TIGR00744   1 IGVDIGGTTIK---LGVVDEEGNIlSKWKVPTDT-TPETIVDAIASAVDSFIQHIAkVGHEIVAIGIGAPGPVNRQRGTV 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502954518  165 IYAPNLDWTNVDVcqqVNRVIQFSVKSIEVHNEANMAALAHTWKrpGCPSGLDTFAYISGGVGVGAAVIENRQLYLGRHG 244
Cdd:TIGR00744  77 YFAVNLDWKQEPL---KEKVEARVGLPVVVENDANAAALGEYKK--GAGKGARDVICITLGTGLGGGIIINGEIRHGHNG 151

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502954518  245 WVGEIGHLTIDPRG-IQCKCGAQGCLERYVGRQAL---------------------------------EIRSGDNAALV- 289
Cdd:TIGR00744 152 VGAEIGHIRMVPDGrLLCNCGKQGCIETYASATGLvryakranakperaevllalgdgdgisakhvfvAARQGDPVAVDs 231

                         250       260       270
                  ....*....|....*....|....*....|.
gi 502954518  290 --ESARALGMALAALTNILDVSLIIIGGDVT 318
Cdd:TIGR00744 232 yrEVARWAGAGLADLASLFNPSAIVLGGGLS 262
PRK09698 PRK09698
D-allose kinase; Provisional
 85-318 1.49e-16

D-allose kinase; Provisional


Pssm-ID: 182034 [Multi-domain]  Cd Length: 302  Bit Score: 79.26  E-value: 1.49e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502954518  85 VSLGVDIGVSWIRMMGLGLGGEEL-FRKQFELDVPALS-SEEVFSLVGNELNLFVSNLSsravifAVTVSVPGLVDSDNG 162
Cdd:PRK09698   5 VVLGIDMGGTHIRFCLVDAEGEILhCEKKRTAEVIAPDlVSGLGEMIDEYLRRFNARCH------GIVMGFPALVSKDRR 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502954518 163 SVIYAPNLDWTNVD-----------------VCQQVNRVIQFSVKSIEVHNEANMAAlahtwkrpgcpsgldtfaYIsgG 225
Cdd:PRK09698  79 TVISTPNLPLTALDlydladklentlncpvfFSRDVNLQLLWDVKENNLTQQLVLGA------------------YL--G 138

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502954518 226 VGVGAAVIENRQLYLGRHGWVGEIGHLTIDPRGIQCKCGAQGCLERYVGRQALE----------------IRSGDNAALV 289
Cdd:PRK09698 139 TGMGFAVWMNGAPWTGAHGVAGELGHIPLGDMTQHCGCGNPGCLETNCSGMALRrwyeqqprdyplsdlfVHAGDHPFIQ 218

                        250       260
                 ....*....|....*....|....*....
gi 502954518 290 ESARALGMALAALTNILDVSLIIIGGDVT 318
Cdd:PRK09698 219 SLLENLARAIATSINLFDPDAIILGGGVM 247
 
Name Accession Description Interval E-value
ASKHA_ATPase_ROK_BsXylR-like cd24076
ATPase-like domain of Bacillus subtilis xylose repressor (XylR) and similar proteins; This ...
 84-365 5.27e-62

ATPase-like domain of Bacillus subtilis xylose repressor (XylR) and similar proteins; This subfamily includes a group of uncharacterized proteins similar to Bacillus subtilis xylose repressor (BsXylR), which belongs to the kinase (ROK) family, a group of proteins that have sugar kinase and/or transcriptional repressor activities. BsXylR acts as transcriptional repressor of xylose-utilizing enzymes.


Pssm-ID: 466926 [Multi-domain]  Cd Length: 303  Bit Score: 201.25  E-value: 5.27e-62
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502954518  84 LVSLGVDIGVSWIRMMGLGLGGEELFRKQFELDvPALSSEEVFSLVGNELNLFVSNL-SSRAVIFAVTVSVPGLVDSDNG 162
Cdd:cd24076    1 GAVIGVELGVDYITVVVTDLAGEVLWRREVPLP-ASDDPDEVLAQLAALIREALAAApDSPLGILGIGVGVPGLVDSEDG 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502954518 163 SVIYAPNLDWTNVDVCQQVNRviQFSVKsIEVHNEANMAALAHtwKRPGCPSGLDTFAYISGGVGVGAAVIENRQLYLGR 242
Cdd:cd24076   80 VVLLAPNLGWRDVPLRDLLEE--ALGVP-VFVDNEANAAALAE--KRFGAGRGVSDLVYLSAGVGIGAGIILDGELYRGA 154

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502954518 243 HGWVGEIGHLTIDPRGIQCKCGAQGCLERYVGRQAL-----------------EI----RSGDNAAL--VESA-RALGMA 298
Cdd:cd24076  155 SGFAGEIGHMTVDPDGPPCSCGNRGCWETYASERALlraagrlgaggeplslaELveaaRAGDPAALaaLEEVgEYLGIG 234

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 502954518 299 LAALTNILDVSLIIIGGDVTNLFADYSEEVKRLMRLHTIADEQRSLQITGSAYEM-PAVRGAAIQGFQ 365
Cdd:cd24076  235 LANLVNTFNPELVVLGGALAPLGPWLLPPLRAEVARRALPAPARDVRIVVSRLGEdAAALGAAALAID 302
NagC COG1940
Sugar kinase of the NBD/HSP70 family, may contain an N-terminal HTH domain [Carbohydrate ...
 85-365 4.28e-61

Sugar kinase of the NBD/HSP70 family, may contain an N-terminal HTH domain [Carbohydrate transport and metabolism, Transcription];


Pssm-ID: 441543 [Multi-domain]  Cd Length: 306  Bit Score: 198.97  E-value: 4.28e-61
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502954518  85 VSLGVDIGVSWIRMMGLGLGGEELFRKQFELDVPAlSSEEVFSLVGNELNLFVSNLS-SRAVIFAVTVSVPGLVDSDNGS 163
Cdd:COG1940    6 YVIGIDIGGTKIKAALVDLDGEVLARERIPTPAGA-GPEAVLEAIAELIEELLAEAGiSRGRILGIGIGVPGPVDPETGV 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502954518 164 VIYAPNL-DWTNVDVCQQVNRVIQFSVksiEVHNEANMAALAHTWKrpGCPSGLDTFAYISGGVGVGAAVIENRQLYLGR 242
Cdd:COG1940   85 VLNAPNLpGWRGVPLAELLEERLGLPV---FVENDANAAALAEAWF--GAGRGADNVVYLTLGTGIGGGIVINGKLLRGA 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502954518 243 HGWVGEIGHLTIDPRGIQCKCGAQGCLERYVGRQALE--------------------IRSGDNAA---LVESARALGMAL 299
Cdd:COG1940  160 NGNAGEIGHMPVDPDGPLCGCGNRGCLETYASGPALLrrarelggaekltaeelfaaARAGDPLAlevLDEAARYLGIGL 239

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 502954518 300 AALTNILDVSLIIIGGDVTNLFADYSEEVKRLMRLHTIADEQRSLQITGSAY-EMPAVRGAAIQGFQ 365
Cdd:COG1940  240 ANLINLLDPEVIVLGGGVSAAGDLLLEPIREALAKYALPPAREDPRIVPASLgDDAGLLGAAALALE 306
ASKHA_ATPase_ROK cd23763
ATPase-like domain of the ROK (Repressor, ORF, Kinase) domain family; The ROK family ...
 87-360 9.12e-44

ATPase-like domain of the ROK (Repressor, ORF, Kinase) domain family; The ROK family corresponds to a group of proteins including sugar kinases, transcriptional repressors, and yet uncharacterized open reading frames. ROK family sugar kinases phosphorylate a range of structurally distinct hexoses including the key carbon source D-glucose, various glucose epimers, and several acetylated hexosamines. The sugar kinases include N-acetyl-D-glucosamine kinase (NAGK; EC 2.7.1.59), polyphosphate glucokinase (PPGK; EC 2.7.1.63/EC 2.7.1.2), glucokinase (GLK; EC 2.7.1.2), fructokinase (FRK; EC 2.7.1.4), hexokinase (HK; EC 2.7.1.1), D-allose kinase (AlsK; EC 2.7.1.55), bifunctional UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase (GNE; EC 3.2.1.183/EC 2.7.1.60), N-acetylmannosamine kinase (NanK; EC 2.7.1.60), beta-glucoside kinase (BglK; EC 2.7.1.85), and N-acetylglucosamine kinase (EC 2.7.1.59). The family also contains the repressor proteins, such as N-acetylglucosamine repressor (NagC), xylose repressor (XylR), cyclobis-(1-6)-alpha-nigerosyl repressor (CYANR) and protein Mlc. ROK kinases harbor a conserved N-terminal ATP binding motif of sequence DxGxT, while ROK repressors possess a N-terminal extension that contains a canonical helix-turn-helix DNA binding motif. The ROK family proteins belong to the ASKHA (Acetate and Sugar Kinases/Hsc70/Actin) superfamily of phosphotransferases, all members of which share a common characteristic five-stranded beta sheet occurring in both the N- and C-terminal domains.


Pssm-ID: 466849 [Multi-domain]  Cd Length: 239  Bit Score: 151.85  E-value: 9.12e-44
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502954518  87 LGVDIGVSWIRMMGLGLGGEELFRKQFELDvPALSSEEVFSLVGNELNLFVSNLSSRAVIFAVTVSVPGLVDSDNGSVIY 166
Cdd:cd23763    1 IGIDIGGTKIRAALVDLDGEILARERVPTP-AEEGPEAVLDRIAELIEELLAEAGVRERILGIGIGVPGPVDPETGIVLF 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502954518 167 APNLD-WTNVDVCQQVNRVIQFSVksiEVHNEANMAALAHTWKrpGCPSGLDTFAYISGGVGVGAAVIENRQLYLGRHGW 245
Cdd:cd23763   80 APNLPwWKNVPLRELLEERLGLPV---VVENDANAAALGEAWF--GAGRGVRNFVYITLGTGIGGGIIIDGKLYRGANGA 154

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502954518 246 VGEIGHLTIdprgiqckcgaqgcleryvgrqaleirsgdnaaLVESARALGMALAALTNILDVSLIIIGGDVTNLFADYS 325
Cdd:cd23763  155 AGEIGHITV---------------------------------LEEAARYLGIGLANLINLLNPELIVLGGGVAEAGDLLL 201

                        250       260       270
                 ....*....|....*....|....*....|....*.
gi 502954518 326 EEVKRLMRLHTIADEQRSLQITGSAY-EMPAVRGAA 360
Cdd:cd23763  202 EPIREAVRRRALPPLRRRVRIVPSELgDDAGLLGAA 237
ASKHA_NBD_ROK_TM1224-like cd24059
nucleotide-binding domain (NBD) of Thermotoga maritima N-acetylglucosamine kinase (TM1224) and ...
 86-368 1.08e-41

nucleotide-binding domain (NBD) of Thermotoga maritima N-acetylglucosamine kinase (TM1224) and similar proteins; This subfamily includes a group of uncharacterized proteins similar to N-acetylglucosamine kinase (Tm1224; EC 2.7.1.59) from Thermotoga maritima, which belongs to kinase (ROK) family, a group of proteins that have sugar kinase and/or transcriptional repressor activities. Tm1224 lacks the cysteine-rich zinc-binding motif, which presents in other family members.


Pssm-ID: 466909 [Multi-domain]  Cd Length: 305  Bit Score: 148.50  E-value: 1.08e-41
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502954518  86 SLGVDIGVSWIrMMGL-GLGGEELFRKQFELDvPALSSEEVFSLVGNELNLFVSNLSSRAVIFAVTVSVPGLVDSDNGSV 164
Cdd:cd24059    3 VIGVEIGRDLL-SAVLcDLSGNILAREKYPLD-EKENPEEVLEKLYELIDRLLEKENIKSKILGIGIGAPGPLDVEKGII 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502954518 165 IYAPNL-DWTNVDVCQQVNRVIQFSVksiEVHNEANMAALAHTWKrpGCPSGLDTFAYISGGVGVGAAVIENRQLYLGRH 243
Cdd:cd24059   81 LNPPNFpGWENIPLVELLEEKFGIPV---YLDNDANAAALAEKWY--GKGKNYDNFIYILADEGIGAGIIINGKLYRGVD 155

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502954518 244 GWVGEIGHLTIDPRGIQCKCGAQGCLERYVGRQALE--IRS------------------GDNAALV---ESARALGMALA 300
Cdd:cd24059  156 GYAGEIGHTSIDINGPRCSCGNRGCLELYASIPAIEkkARSalgsgrsfqldivealqkGDPIADEvieEAAKYLGIGLV 235

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 502954518 301 ALTNILDVSLIIIGGDVTNLFADYSEEVKRLMRLHTIADEQRSLQI-TGSAYEMPAVRGAAIQGFQALL 368
Cdd:cd24059  236 NLINLLNPEAIIIGGELIYLGERYLEPIEKEVNSRLFGRNAREVRIlKSSLGEDAPLLGAAALVLNKYF 304
ASKHA_ATPase_ROK_CYANR cd24073
ATPase-like domain of cyclobis-(1-6)-alpha-nigerosyl repressor (CYANR) and similar proteins; ...
 138-347 5.98e-36

ATPase-like domain of cyclobis-(1-6)-alpha-nigerosyl repressor (CYANR) and similar proteins; CYANR acts as transcriptional repressor of cyclobis-(1-6)-alpha-nigerosyl (CNN) degrading enzymes. Members of this subfamily belong to the kinase (ROK) family, a group of proteins that have sugar kinase and/or transcriptional repressor activities.


Pssm-ID: 466923 [Multi-domain]  Cd Length: 304  Bit Score: 133.06  E-value: 5.98e-36
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502954518 138 SNLSSRAVIfAVTVSVPGLVDSDNGSVIYAPNLDWTNVDVCQQVNRVIQFSVkSIEvhNEANMAALAHTWKRPGcpSGLD 217
Cdd:cd24073   55 AGLSPDRLL-GIGVGLPGLVDAETGICRWSPLLGWRDVPLAELLEERLGLPV-YVE--NDVNALALAEHWFGAG--RGLD 128

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502954518 218 TFAYISGGVGVGAAVIENRQLYLGRHGWVGEIGHLTIDPRGIQCKCGAQGCLERYVG-----RQALEI------------ 280
Cdd:cd24073  129 NFAVVTIGRGIGCGLVVDGRLYRGAHGGAGEIGHTTVDPDGPPCRCGKRGCLEAYASdpailRQAREAglrgepltiedl 208

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 502954518 281 ----RSGDNAA---LVESARALGMALAALTNILDVSLIIIGGDVTNLFADYSEEVKRLMRLHTIADEQRSLQIT 347
Cdd:cd24073  209 laaaRAGDPAAraiLRRAGRALGLALANLVNLLDPELIIISGEGVRAGDLLFEPMREALRAHVFPGLASDLELV 282
ASKHA_ATPase_ROK_SaXylR-like cd24077
ATPase-like domain of Staphylococcus aureus xylose repressor (XylR) and similar proteins; This ...
 86-364 2.56e-35

ATPase-like domain of Staphylococcus aureus xylose repressor (XylR) and similar proteins; This subfamily includes a group of uncharacterized proteins similar to Staphylococcus aureus xylose repressor (SaXylR), which belongs to the kinase (ROK) family, a group of proteins that have sugar kinase and/or transcriptional repressor activities. SaXylR acts as a transcriptional repressor of xylose-utilizing enzymes. It lacks the cysteine-rich zinc-binding motif, which presents in other family members.


Pssm-ID: 466927 [Multi-domain]  Cd Length: 295  Bit Score: 131.12  E-value: 2.56e-35
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502954518  86 SLGVDIGVSWIRMMGLGLGGEELFRKQFELDVPalSSEEVFSLVGNELNLFVSNL-SSRAVIFAVTVSVPGLVDSDNgsV 164
Cdd:cd24077    3 SIGIDLGYNYISLMLTYLDGEIISSKQIKLLDI--SFENILEILKSIIQELISQApKTPYGLVGIGIGIHGIVDENE--I 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502954518 165 IYAPNLDWTNVDVCQQVNRVIQFSVkSIEvhNEANMAALAHTwkrpgcpsgldTFAY-------ISGGVGVGAAVIENRQ 237
Cdd:cd24077   79 IFTPYYDLEDIDLKEKLEEKFNVPV-YLE--NEANLSALAER-----------TFSEdydnlisISIHSGIGAGIIINNQ 144

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502954518 238 LYLGRHGWVGEIGHLTIDPRGIQCKCGAQGCLERYVGRQAL--------------------EIRSGDNAALV---ESARA 294
Cdd:cd24077  145 LYRGYNGFAGEIGHMIIVPNGKPCPCGNKGCLEQYASEKALlkelsekkgletltfddliqLYNEGDPEALElidQFIKY 224

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 502954518 295 LGMALAALTNILDVSLIIIGGDVTNLFADYSEEVKRlmRLHTIADEQRSLQITGSAYEMPAVRGAA--IQGF 364
Cdd:cd24077  225 LAIGINNIINTFNPEIIIINSSLINEIPELLEKIKE--QLSSSFNKYVEILISTLGKNATLLGGAAvaIKNF 294
ASKHA_NBD_ROK_SgGLK-like cd24061
nucleotide-binding domain (NBD) of Streptomyces griseus glucokinase (GLK) and similar proteins; ...
 86-317 1.13e-34

nucleotide-binding domain (NBD) of Streptomyces griseus glucokinase (GLK) and similar proteins; Glucokinase (EC 2.7.1.2), also called glucose kinase, acts as an ATP-dependent kinase that phosphorylates glucose using ATP as a donor to give glucose-6-phosphate and ADP. It is highly specific for glucose. Glucokinases are found in invertebrates and microorganisms. They belong to the kinase (ROK) family, a group of proteins that have sugar kinase and/or transcriptional repressor activities.


Pssm-ID: 466911 [Multi-domain]  Cd Length: 306  Bit Score: 129.78  E-value: 1.13e-34
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502954518  86 SLGVDIGVSWIRMMGLGLGGEELfrKQFELDVPALSSEEVFSLVGnelnlFVSNLSSRAVIFAVTVSVPGLVDSDNGSVI 165
Cdd:cd24061    1 TIGVDIGGTKIAAGVVDEEGEIL--ATERVPTPPTADGIVDAIVE-----AVEELREGHDVSAVGVAAAGFVDADRATVL 73

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502954518 166 YAPNLDWTNVDVCQQVNRVIQFSVkSIEvhNEANMAALAHTwkRPGCPSGLDTFAYISGGVGVGAAVIENRQLYLGRHGW 245
Cdd:cd24061   74 FAPNIAWRNEPLKDLLEARIGLPV-VIE--NDANAAAWAEY--RFGAGRGTDDMVMITVGTGLGGGIVIGGKLLRGAFGI 148

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502954518 246 VGEIGHLTIDPRGIQCKCGAQGCLERY-----VGRQALEI-----------------------------RSGDNAALV-- 289
Cdd:cd24061  149 AGEFGHIRVVPDGLLCGCGSRGCWEQYasgraLVRYAKEAanatpegaavlladgsvdgitgkhiseaaRAGDPVALDal 228

                        250       260
                 ....*....|....*....|....*....
gi 502954518 290 -ESARALGMALAALTNILDVSLIIIGGDV 317
Cdd:cd24061  229 rELARWLGAGLASLAALLDPELFVIGGGV 257
ASKHA_ATPase_ROK_Lmo0178-like cd24071
ATPase-like domain of Listeria monocytogenes Lmo0178 and similar proteins; This subfamily ...
 87-315 4.42e-34

ATPase-like domain of Listeria monocytogenes Lmo0178 and similar proteins; This subfamily includes a group of uncharacterized proteins similar to Listeria monocytogenes Lmo0178 protein, which is a predicted transcription repressor belonging to the kinase (ROK) family, a group of proteins that have sugar kinase and/or transcriptional repressor activities.


Pssm-ID: 466921 [Multi-domain]  Cd Length: 312  Bit Score: 128.17  E-value: 4.42e-34
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502954518  87 LGVDIGVSWIRMMGLGLGGEELFRKQFELDVPAlSSEEVFSLVGNELNLFVSNLSSRAVIFAVTVSVPGLVDSDNGSVIY 166
Cdd:cd24071    4 IGVKIEEGYLVLALTDLKGKILEKTRIPFDHET-DPEKVIELIAENIKKLIKNKHVEKKLLGIGIAVSGLVDSKKGIVIR 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502954518 167 APNLDWTNVDVCQQVNRViqFSVKSIeVHNEANMAALAHTWKrpGCPSGLDTFAYISGGVGVGAAVIENRQLYLGRHGWV 246
Cdd:cd24071   83 STILGWENVELKKILKEK--FKIPVF-IDNDVNSFALAELWK--GKGKGYSNFICVTVGAGIGSSLVIDGKLYTGNFGGA 157

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502954518 247 GEIGHLTIDPRGIQCKCGAQGCLERYVGRQALE-----------------------------IRSGDNAA---LVESARA 294
Cdd:cd24071  158 GEIGHMTIQPDGRKCYCGQKGCLEAYASFEALVneikeltesyplsllkeledfeiekvreaAEEGDSVAtelFKKAGEY 237

                        250       260
                 ....*....|....*....|.
gi 502954518 295 LGMALAALTNILDVSLIIIGG 315
Cdd:cd24071  238 LGIGIKNLINIFNPEAIIIGG 258
ROK pfam00480
ROK family; This family, known as ROK (Repressor, ORF, Kinase) includes the xylose operon ...
 87-319 1.27e-33

ROK family; This family, known as ROK (Repressor, ORF, Kinase) includes the xylose operon repressor, xylR, from Bacillus subtilis, Lactobacillus pentosus and Staphylococcus xylosus; N-acetylglucosamine repressor, nagC, from Escherichia coli; glucokinase from Streptomyces coelicolor; fructokinase from from Pediococcus pentosaceus, Streptococcus mutans and Zymomonas mobilis; allokinase and mlc from E. coli; and E. coli hypothetical proteins yajF and yhcI and the corresponding Haemophilus influenzae proteins. The repressor proteins (xylR and nagC) from this family possess an N-terminal region not present in the sugar kinases and which contains an helix-turn-helix DNA-binding motif.


Pssm-ID: 395384 [Multi-domain]  Cd Length: 292  Bit Score: 126.69  E-value: 1.27e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502954518   87 LGVDIGVSWIRMMGLGLGGEELFRKQFEldVPALSSEEVfslVGNELNLFVSNLSSRA-VIFAVTVSVPGLVDSDNGSVI 165
Cdd:pfam00480   1 IGIDIGGTKIAAALFDEEGEILARERVP--TPTTTTEET---LVDAIAFFVDSAQRKFgELIAVGIGSPGLISPKYGYIT 75

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502954518  166 YAPNLDWTNVDVC----QQVNRviqfsvkSIEVHNEANMAALAHTWKrpGCPSGLDTFAYISGGVGVGAAVIENRQLYLG 241
Cdd:pfam00480  76 NTPNIGWDNFDLVekleERFNV-------PVFFENDANAAALAEAVF--GASKDVQNVIYVTVGTGVGGGVISNGKLFTG 146

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502954518  242 RHGWVGEIGHLTIDPRGIQCKCGAQGCLERYVGRQALEIRSGD---------------------NAALVESARALGMALA 300
Cdd:pfam00480 147 RNGVAGEIGHIQLDPNGPKCGCGNHGCLETIASGRALEKRYQQkgedlegkdiivlaeqgdevaEEAVERLARYLAKAIA 226

                         250
                  ....*....|....*....
gi 502954518  301 ALTNILDVSLIIIGGDVTN 319
Cdd:pfam00480 227 NLINLFDPQAIVLGGGVSN 245
ASKHA_NBD_ROK_FnNanK-like cd24068
nucleotide-binding domain (NBD) of Fusobacterium nucleatum N-acetylmannosamine kinase and ...
 87-360 1.79e-33

nucleotide-binding domain (NBD) of Fusobacterium nucleatum N-acetylmannosamine kinase and similar proteins; The family includes Fusobacterium nucleatum N-acetylmannosamine kinase (NanK; EC 2.7.1.60) and beta-glucoside kinase (BglK; EC 2.7.1.85) from Klebsiella pneumoniae and Listeria innocua. NanK catalyzes the second step of the sialic acid catabolic pathway, transferring a phosphate group from adenosine 5'-triphosphate to the C6 position of N-acetylmannosamine to generate N-acetylmannosamine 6-phosphate. Unlike other NanK enzymes and ROK family members, F. nucleatum NanK does not have a conserved zinc-binding site. BglK catalyzes the ATP-dependent phosphorylation of cellobiose to produce cellobiose-6'-P. It may have a dual role of kinase and transcriptional regulator of the cellobiose-PTS operon. The subfamily belongs to the kinase (ROK) family, a group of proteins that have sugar kinase and/or transcriptional repressor activities. Members of this subfamily lack the cysteine-rich zinc-binding motif, which presents in other ROK families.


Pssm-ID: 466918 [Multi-domain]  Cd Length: 294  Bit Score: 126.13  E-value: 1.79e-33
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502954518  87 LGVDIGVSWIRMmGLGLGGEELFRKqFELDVPAlssEEVFSLVGNELNLFVSNLSSRAVIFAVTVSVPGLVDSDNGSVIY 166
Cdd:cd24068    3 LGIDIGGTKIKY-GLVDADGEILEK-DSVPTPA---SKGGDAILERLLEIIAELKEKYDIEGIGISSAGQVDPKTGEVIY 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502954518 167 A-PNL-DWTNVDVCQQVNRVIQFSVksiEVHNEANMAALAHTWKRPGcpSGLDTFAYISGGVGVGAAVIENRQLYLGRHG 244
Cdd:cd24068   78 AtDNLpGWTGTNLKEELEERFGLPV---AVENDVNCAALAEKWLGAA--KGLDDFLCLTLGTGIGGAIILDGRLYRGANG 152

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502954518 245 WVGEIGHLTIDPRGIQCKCGAQGCLERYVG-----RQALE---------------IRSGDNAA--LVES-ARALGMALAA 301
Cdd:cd24068  153 SAGELGHMVVDPGGRPCCCGGKGCLEQYASgtalvRRVAEalgepgidgreifdlADAGDPLAkeVVEEfAEDLATGLAN 232

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 502954518 302 LTNILDVSLIIIGGDVTNLFADYSEEVKRLMRLHTIADEQRSLQITGSAYEMPA-VRGAA 360
Cdd:cd24068  233 LVHIFDPEVIVIGGGISAQGELFLEELREELRKLLMPPLLDATKIEPAKLGNDAgLLGAA 292
ASKHA_NBD_ROK_BsGLK-like cd24062
nucleotide-binding domain (NBD) of Bacillus subtilis glucokinase (GLK) and similar proteins; ...
 87-319 1.09e-29

nucleotide-binding domain (NBD) of Bacillus subtilis glucokinase (GLK) and similar proteins; Glucokinase (EC 2.7.1.2), also called glucose kinase, acts as an ATP-dependent kinase that phosphorylates glucose using ATP as a donor to give glucose-6-phosphate and ADP. It is highly specific for glucose. Glucokinases are found in invertebrates and microorganisms. They belong to the kinase (ROK) family, a group of proteins that have sugar kinase and/or transcriptional repressor activities.


Pssm-ID: 466912 [Multi-domain]  Cd Length: 311  Bit Score: 116.24  E-value: 1.09e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502954518  87 LGVDIGVSWIRMMGLGLGGEELFRKQFELDVPALSSEEVFSLVGNELNLFVSNLSSRAVIFAVTVSVPGLVDSDNGSVIY 166
Cdd:cd24062    3 VGIDVGGTTIKMAFLTQEGEIVQKWEIPTNKLEGGENIITDIAESIQQLLEELGYSKEDLIGIGVGVPGPVDVETGTVEV 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502954518 167 APNLDWTNVDVCQQVNRVIQFSVksiEVHNEANMAALAHTWKrpGCPSGLDTFAYISGGVGVGAAVIENRQLYLGRHGWV 246
Cdd:cd24062   83 AVNLGWKNFPLKDKLEALTGIPV---VIDNDANAAALGEMWK--GAGQGAKDLVFITLGTGVGGGVIANGKIVHGANGAA 157

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502954518 247 GEIGHLTIDPR-GIQCKCGAQGCLERY--------VGRQALEIRS-------------------------GDNAAL---V 289
Cdd:cd24062  158 GEIGHITVNPEgGAPCNCGKTGCLETVasatgivrIAREELEEGKgssalrilalggeltakdvfeaakaGDELALavvD 237

                        250       260       270
                 ....*....|....*....|....*....|
gi 502954518 290 ESARALGMALAALTNILDVSLIIIGGDVTN 319
Cdd:cd24062  238 TVARYLGLALANLANTLNPEKIVIGGGVSA 267
ASKHA_NBD_ROK_AlsK cd24070
nucleotide-binding domain (NBD) of D-allose kinase (AlsK) and similar proteins; AlsK (EC 2.7.1. ...
 87-319 7.92e-27

nucleotide-binding domain (NBD) of D-allose kinase (AlsK) and similar proteins; AlsK (EC 2.7.1.55), also called allokinase, catalyzes the phosphorylation of D-allose to D-allose 6-phosphate. It has also low level glucokinase activity in vitro. Members of this subfamily belong to the kinase (ROK) family, a group of proteins that have sugar kinase and/or transcriptional repressor activities.


Pssm-ID: 466920 [Multi-domain]  Cd Length: 293  Bit Score: 108.02  E-value: 7.92e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502954518  87 LGVDIGVSWIRMmglGLGGEELFRKQFELdvpaLSSEEVFSlVGNelnlFVSNLS---------SRAVIFAVTVSVPGLV 157
Cdd:cd24070    4 LGIDIGGTNIRI---GLVDEDGKLLDFEK----VPSKDLLR-AGD----PVEVLAdlireyieeAGLKPAAIVIGVPGTV 71

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502954518 158 DSDNGSVIYAPNLD-WTNVDVCQQVNRVIQFSVksiEVHNEANMAALAHTWKRPGCPSGLDTFAYIsgGVGVGAAVIENR 236
Cdd:cd24070   72 DKDRRTVISTPNIPgLDGVNLADILENKLGIPV---ILERDVNLLLLYDMRAGNLDDEGVVLGFYI--GTGIGNAILING 146

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502954518 237 QLYLGRHGWVGEIGHLTIDPRGIQCKCGAQGCLERYVGRQALE----------------IRSGDNAALVESARALGMALA 300
Cdd:cd24070  147 KPLRGKNGVAGELGHIPVYGNGKPCGCGNTGCLETYASGRALEeiaeehypdtpildifVDHGDEPELDEFVEDLALAIA 226

                        250
                 ....*....|....*....
gi 502954518 301 ALTNILDVSLIIIGGDVTN 319
Cdd:cd24070  227 TEINILDPDAVILGGGVID 245
ASKHA_ATPase_ROK_YphH-like cd24072
ATPase-like domain of Escherichia coli protein YphH and similar proteins; This subfamily ...
 149-315 1.10e-26

ATPase-like domain of Escherichia coli protein YphH and similar proteins; This subfamily includes a group of uncharacterized proteins similar to Escherichia coli protein YphH that belongs to the kinase (ROK) family, a group of proteins that have sugar kinase and/or transcriptional repressor activities.


Pssm-ID: 466922 [Multi-domain]  Cd Length: 308  Bit Score: 108.27  E-value: 1.10e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502954518 149 VTVSVPGLVDSDNGSVIYAPNLDWTNVDVCQQVNRVIQfsvKSIEVHNEANMAALAHTWKrpGCPSGLDTFAYISGGVGV 228
Cdd:cd24072   63 IALAIQGLVDSHKGVSLWSPGAPWRNIEIKYLLEERYG---IPVFVENDCNMLALAEKWQ--GELRQSRDFCVINLDYGI 137

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502954518 229 GAAVIENRQLYLGRHGWVGEIGHLTIDPRGIQCKCGAQGCLERYVGRQAL---------------EIRSGDNAALVESAR 293
Cdd:cd24072  138 GSAIVIDNKLYIGASSGSGEIGHTKVNPDGARCDCGRRGCLETVASNSALkrnarvtlklgpvsaDPEKLTMEQLIEALE 217

                        170       180       190
                 ....*....|....*....|....*....|....*..
gi 502954518 294 ---------------ALGMALAALTNILDVSLIIIGG 315
Cdd:cd24072  218 egepiatqifdraanAIGRSLANILNLLNPEQVLLYG 254
ASKHA_ATPase_ROK_NagC cd24075
ATPase-like domain of N-acetylglucosamine repressor (NagC) and similar proteins; NagC acts as ...
 103-371 2.31e-24

ATPase-like domain of N-acetylglucosamine repressor (NagC) and similar proteins; NagC acts as a repressor of the nagEBACD operon involved in the uptake and degradation of the amino sugars, N-acetyl-D-glucosamine (GlcNAc) and glucosamine (GlcN). It acts both as an activator and a repressor for the transcription of the glmSU operon, encoding proteins necessary for the synthesis of GlcN (glmS) and the formation of UDP-GlcNAc (glmU). Members of this subfamily belong to the kinase (ROK) family, a group of proteins that have sugar kinase and/or transcriptional repressor activities.


Pssm-ID: 466925 [Multi-domain]  Cd Length: 315  Bit Score: 101.67  E-value: 2.31e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502954518 103 LGGEELFRKQfeLDVPALSSEEVFSLVGNELNLFV-SNLSSRAVIFAVTVSVPGLVDSDNGSVIYAPNLDWTNVDVCQQV 181
Cdd:cd24075   20 LSGELLAEHT--VPLTALNQEALLSQLIEEIAQFLkSHRRKTQRLIAISITLPGLINPKTGVVHYMPHIQVKSWPIVEEL 97

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502954518 182 NRViqFSVKSIEVHNEANMAALAHTWkrpGCPSGLDTFAYISGGVGVGAAVIENRQLYLGRHGWVGEIGHLTIDPRGIQC 261
Cdd:cd24075   98 EQR--FNVPCFIGNDIRSLALAEHYF---GASKDCKDSILVRIHHGIGAGIIIDGKLFLGQNGNAGEIGHIQIEPLGERC 172

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502954518 262 KCGAQGCLERYVGRQALEIR----------------------------SGDNAA---LVESARALGMALAALTNILDVSL 310
Cdd:cd24075  173 HCGNFGCLETVASNAAIEQRvkkllkqgyasqltlqdctikdicqaalNGDQLAqdvIKRAGRYLGKVIAILINLLNPQK 252

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 502954518 311 IIIGGDVTNLFADYSEEVKRLMRLHTIADEQRSLQITGSAYEMPAVRGAAIQGFQALLDAP 371
Cdd:cd24075  253 IIIAGEITQADKVLLPVIKKCIQSQALPDFRQELKIVASQLDHNSAIGAFALVKRALLEGG 313
ASKHA_NBD_ROK_TmGLK-like cd24064
nucleotide-binding domain (NBD) of Thermotoga maritima glucokinase (GLK) and similar proteins; ...
 87-363 7.17e-24

nucleotide-binding domain (NBD) of Thermotoga maritima glucokinase (GLK) and similar proteins; Glucokinase (EC 2.7.1.2), also called glucose kinase, acts as an ATP-dependent kinase that phosphorylates glucose using ATP as a donor to give glucose-6-phosphate and ADP. It is highly specific for glucose. Glucokinases are found in invertebrates and microorganisms. They belong to the kinase (ROK) family, a group of proteins that have sugar kinase and/or transcriptional repressor activities.


Pssm-ID: 466914 [Multi-domain]  Cd Length: 301  Bit Score: 100.26  E-value: 7.17e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502954518  87 LGVDIGVSWIRMMGLGLGGEELFRKQFELDVpalssEEVFSLVGNELNLFVSNLSSRAVIFAVTVSVPGLVDSDNGSVIY 166
Cdd:cd24064    2 IGIDLGGTDTKIGIVDENGDILKKKTIDTKV-----ENGKEDVINRIAETVNELIEEMELLGIGIGSPGSIDRENGIVRF 76

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502954518 167 APNL-DWTNVDVCQQVNRVIQFSVKsieVHNEANMAALAHTWKrpGCPSGLDTFAYISGGVGVGAAVIENRQLYLGRHGW 245
Cdd:cd24064   77 SPNFpDWRNFPLVPLIEERTGIKVF---LENDANAFALGEWWF--GNAKGSNHIIGLTLGTGVGSGVICHGQLLTGYDGI 151

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502954518 246 VGEIGHLTIDPRGIQCKCGAQGCLE-----------------RYVGRQALEIRSGDNAALVESAR--------------- 293
Cdd:cd24064  152 AAELGHVIVEPNGPICGCGNRGCVEafasataiiryaresrkRYPDSLAGESEKINAKHVFDAARkndplatmvfrrvvd 231

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 502954518 294 ALGMALAALTNILDVSLIIIGGDVTN----LFADYSEEVKRLMrlhtiadeQRSLQITGSAYEMPAVRGAAIQG 363
Cdd:cd24064  232 ALAIAIGGFVHIFNPEIIIIGGGISRagsfLLDPIREKTKKYV--------MLSFQDTYSIELSNLVEDAGILG 297
ASKHA_NBD_ROK_ApGLK-like cd24063
nucleotide-binding domain (NBD) of Aeropyrum pernix glucokinase (GLK) and similar proteins; ...
 87-319 1.20e-23

nucleotide-binding domain (NBD) of Aeropyrum pernix glucokinase (GLK) and similar proteins; Glucokinase (EC 2.7.1.2), also called glucose kinase, acts as an ATP-dependent kinase that phosphorylates glucose using ATP as a donor to give glucose-6-phosphate and ADP. It is highly specific for glucose. Glucokinases are found in invertebrates and microorganisms. They belong to the kinase (ROK) family, a group of proteins that have sugar kinase and/or transcriptional repressor activities.


Pssm-ID: 466913 [Multi-domain]  Cd Length: 308  Bit Score: 99.72  E-value: 1.20e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502954518  87 LGVDIGVSWIRMmGLGLGGEELFRKQFElDVPALSSEEVFSLVGNELNLFVSNLSSRAVIFAVTVSVPGLVDSDNGSVIY 166
Cdd:cd24063    3 VAVDIGGTWIRA-GLVDEDGRILLKIRQ-PTPKTGDPGTVSEQVLGLIETLLSKAGKDSIEGIGVSSAGPLDLRKGTIVN 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502954518 167 APNLDWTNVDVCQQVNRviQFSVKSIeVHNEANMAALAHTWKrpGCPSGLDTFAYISGGVGVGAAVIENRQLYLGRHGWV 246
Cdd:cd24063   81 SPNIKGKEIPLVEPLKE--EFNIPVA-LLNDAVAAALGEHLF--GAGRGTSNLVYITISTGIGGGVIVDGRLLLGKNGNA 155

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502954518 247 GEIGHLTIDPR-GIQCKCGAQGCLERYVG-----RQALEI-----------------------------RSGDNAALV-- 289
Cdd:cd24063  156 AEVGHLVVDTEsGLKCGCGGYGHWEAFASgrgipRFAREWaegfssrtslklrnpggegitakevfsaaRKGDPLALKii 235

                        250       260       270
                 ....*....|....*....|....*....|.
gi 502954518 290 -ESARALGMALAALTNILDVSLIIIGGDVTN 319
Cdd:cd24063  236 eKLARYNGRGIANVINAYDPELIVIGGSVFN 266
ASKHA_NBD_ROK_TtHK-like cd24065
nucleotide-binding domain (NBD) of Thermus thermophilus hexokinase (HK) and similar proteins; ...
 148-336 4.75e-23

nucleotide-binding domain (NBD) of Thermus thermophilus hexokinase (HK) and similar proteins; HK (EC 2.7.1.1) possesses the ability to transfer an inorganic phosphate group from ATP to a substrate. It catalyzes the ATP-dependent phosphorylation of aldo- and keto-hexose sugars to the hexose-6-phosphate (H6P). Thermus thermophilus HK possesses significant enzymatic activity against glucose and mannose. However, it shows little catalytic capacity for galactose and fructose. Members of this subfamily belong to the kinase (ROK) family, a group of proteins that have sugar kinase and/or transcriptional repressor activities.


Pssm-ID: 466915 [Multi-domain]  Cd Length: 289  Bit Score: 97.79  E-value: 4.75e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502954518 148 AVTVSVPGLVDSDNGSVIYAPNL-DWTNVDVCQQVNRVIQfsvKSIEVHNEANMAALAHtwKRPGCPSGLDTFAYISGGV 226
Cdd:cd24065   58 AVGLGVPGPLDFRRGRVRFAPNIpGLTDFPIRRGLAERLG---LPVVLENDANAAALAE--HHYGAARGTESSVYVTIST 132

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502954518 227 GVGAAVIENRQLYLGRHGWVGEIGHLTIDPRGIQCKCGAQGCLE------------RYVGRQALEI-------RSGDNAA 287
Cdd:cd24065  133 GIGGGLVLGGRVLRGRHGQAGEIGHTTVLPGGPMCGCGLVGCLEalasgralardaSFAYGRPMSTaelfelaQQGEPKA 212

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|..
gi 502954518 288 ---LVESARALGMALAALTNILDVSLIIIGGDVTNLFADYSEEVKRLMRLHT 336
Cdd:cd24065  213 lriVEQAAAHLGIGLANLQKALDPEVFVLGGGVAQVGDYYLLPVQEAARRYT 264
ROK_glcA_fam TIGR00744
ROK family protein (putative glucokinase); This model models one branch of the ROK superfamily ...
 87-318 2.32e-22

ROK family protein (putative glucokinase); This model models one branch of the ROK superfamily of proteins. The three members of the seed alignment for this model all have experimental evidence for activity as glucokinase, but the set of related proteins is crowded with paralogs of different or unknown function. Proteins scoring above the trusted_cutoff will show strong similarity to at least one known glucokinase and may be designated as putative glucokinases. However, definitive identification of glucokinases should be done only with extreme caution. [Unknown function, General]


Pssm-ID: 273246 [Multi-domain]  Cd Length: 318  Bit Score: 96.12  E-value: 2.32e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502954518   87 LGVDIGVSWIRmmgLGLGGEELFR-KQFELDVPAlSSEEVFSLVGNELNLFVSNLS-SRAVIFAVTVSVPGLVDSDNGSV 164
Cdd:TIGR00744   1 IGVDIGGTTIK---LGVVDEEGNIlSKWKVPTDT-TPETIVDAIASAVDSFIQHIAkVGHEIVAIGIGAPGPVNRQRGTV 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502954518  165 IYAPNLDWTNVDVcqqVNRVIQFSVKSIEVHNEANMAALAHTWKrpGCPSGLDTFAYISGGVGVGAAVIENRQLYLGRHG 244
Cdd:TIGR00744  77 YFAVNLDWKQEPL---KEKVEARVGLPVVVENDANAAALGEYKK--GAGKGARDVICITLGTGLGGGIIINGEIRHGHNG 151

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502954518  245 WVGEIGHLTIDPRG-IQCKCGAQGCLERYVGRQAL---------------------------------EIRSGDNAALV- 289
Cdd:TIGR00744 152 VGAEIGHIRMVPDGrLLCNCGKQGCIETYASATGLvryakranakperaevllalgdgdgisakhvfvAARQGDPVAVDs 231

                         250       260       270
                  ....*....|....*....|....*....|.
gi 502954518  290 --ESARALGMALAALTNILDVSLIIIGGDVT 318
Cdd:TIGR00744 232 yrEVARWAGAGLADLASLFNPSAIVLGGGLS 262
ASKHA_NBD_ROK_GNE cd24060
nucleotide-binding domain (NBD) of bifunctional UDP-N-acetylglucosamine 2-epimerase ...
 146-360 4.24e-18

nucleotide-binding domain (NBD) of bifunctional UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase (GNE) and similar proteins; GNE (EC 3.2.1.183/EC 2.7.1.60), also called UDP-GlcNAc-2-epimerase/ManAc kinase, is a bi-functional enzyme that plays a key role in sialic acid biosynthesis. It regulates and initiates biosynthesis of N-acetylneuraminic acid (NeuAc), a precursor of sialic acids. It plays an essential role in early development and required for normal sialylation in hematopoietic cells. Sialylation is implicated in cell adhesion, signal transduction, tumorigenicity and metastatic behavior of malignant cells. GNE is the only human protein that contains a kinase domain belonging to the ROK (repressor, ORF, kinase) family. Mutations of the GNE protein cause sialurea or autosomal recessive inclusion body myopathy/Nonaka myopathy.


Pssm-ID: 466910 [Multi-domain]  Cd Length: 305  Bit Score: 84.00  E-value: 4.24e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502954518 146 IFAVTVSVPGLVDSDNGSVIYAPNL--DWTNVDVCQQVNRVIQFSVksiEVHNEANMAALAHTWKRPGcpSGLDTFAYIS 223
Cdd:cd24060   60 ILGVGISTGGRVNPREGIVLHSTKLiqEWSSVDLRTPISDALHLPV---WVDNDGNCAALAERKFGHG--KGVENFVTVI 134

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502954518 224 GGVGVGAAVIENRQLYLGRHGWVGEIGHLTIDPRGIQCKCGAQGCLERYVGRQALE------------------IRSGD- 284
Cdd:cd24060  135 TGTGIGGGIILNHELIHGSSFCAAELGHIVVSLDGPDCMCGSHGCVEAYASGMALQreakklhdedlllvegmsVTNDEe 214

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502954518 285 -------NAA----------LVESARALGMALAALTNILDVSLIIIGGDVTNLFADYSEEVKRLMRLHTIadeqRSLQIT 347
Cdd:cd24060  215 vtakhliQAAklgnakaqkiLRTAGTALGLGIVNILHTLNPSLVILSGVLASHYENIVKDVIAQRALPSV----QNVDVV 290

                        250
                 ....*....|...
gi 502954518 348 GSAYEMPAVRGAA 360
Cdd:cd24060  291 VSDLVDPALLGAA 303
ASKHA_NBD_ROK-like cd24152
nucleotide-binding domain (NBD) of an uncharacterized subgroup of the ROK family; This ...
 111-331 2.22e-17

nucleotide-binding domain (NBD) of an uncharacterized subgroup of the ROK family; This subfamily is composed of uncharacterized proteins belonging to the the kinase (ROK) family, a group of proteins that have sugar kinase and/or transcriptional repressor activities. Members of this subfamily lack the cysteine-rich zinc-binding motif, which presents in other ROK families.


Pssm-ID: 466988 [Multi-domain]  Cd Length: 286  Bit Score: 81.46  E-value: 2.22e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502954518 111 KQFELDVPALSSEEVFSLVGNELNLFVSNLSsravifAVTVSVPGLVDSDNGSVIY-APNLDWTNVDVCQQVNRVIQFSV 189
Cdd:cd24152   25 KKGKIPTPKDSLEEFLDYIKKIIKRYDEEID------GIAISAPGVIDPETGIIYGgGALPYLKGFNLKEELEERCNLPV 98

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502954518 190 kSIEvhNEANMAALAHTWKrpGCPSGLDTFAYISGGVGVGAAVIENRQLYLGRHGWVGEIGHLTIDP-----RGIQCKCG 264
Cdd:cd24152   99 -SIE--NDAKCAALAELWL--GSLKGIKNGAVIVLGTGIGGAIIIDGKLYRGSHFFAGEFSYLLTDDddkdlLFFSGLAS 173

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502954518 265 AQGCLERYV---------GRQALE-IRSGDNAA---LVESARALGMALAALTNILDVSLIIIGGDVTN---LFADYSEEV 328
Cdd:cd24152  174 MFGLVKRYNkakglepldGEEIFEkYAKGDEAAkkiLDEYIRNLAKLIYNIQYILDPEVIVIGGGISEqplFIEDLKKEV 253


                 ...
gi 502954518 329 KRL 331
Cdd:cd24152  254 NEI 256
ASKHA_ATPase_ROK_Mlc cd24074
ATPase-like domain of protein Mlc and similar proteins; Mlc, also called making large colonies ...
 148-369 3.09e-17

ATPase-like domain of protein Mlc and similar proteins; Mlc, also called making large colonies protein, acts as a transcriptional repressor that regulates the expression of proteins that are part of the phosphotransferase system for sugar uptake. It regulates the expression of malT. Members of this subfamily belong to the kinase (ROK) family, a group of proteins that have sugar kinase and/or transcriptional repressor activities.


Pssm-ID: 466924 [Multi-domain]  Cd Length: 322  Bit Score: 81.59  E-value: 3.09e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502954518 148 AVTVSVPGLVDSDNGSVIYAPNLDWTNVDVCQQVNRVIQFSVKsieVHNEANMAALA-HTWkrpGCPSGLDTFAYISGGV 226
Cdd:cd24074   65 AIAITLPGIIDPESGIVHRLPFYDIKNLPLGEALEQHTGLPVY---VQHDISAWTLAeRFF---GAAKGAKNIIQIVIDD 138

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502954518 227 GVGAAVIENRQLYLGRHGWVGEIGHLTIDPRGIQCKCGAQGCLERYVGRQALE--------------------------- 279
Cdd:cd24074  139 DIGAGVITDGQLLHAGSSRLGELGHTQIDPYGKRCYCGNHGCLETVASIPAILeqanqlleqspdsmlhgqpisieslcq 218

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502954518 280 -IRSGDNAA---LVESARALGMALAALTNILDVSLIIIGGDVTN----LFADYSEEVkrlmRLHTIADEQRSLQITGSAY 351
Cdd:cd24074  219 aALAGDPLAqdiIIQVGRHLGRILAILVNLFNPEKILIGSPLNNaaeiLFPALSQSI----RQQSLPAYSQHLQIESTKF 294

                        250
                 ....*....|....*...
gi 502954518 352 EMPAVRGAAIQGFQALLD 369
Cdd:cd24074  295 YNDGTMPGAALIKDALYD 312
PRK09698 PRK09698
D-allose kinase; Provisional
 85-318 1.49e-16

D-allose kinase; Provisional


Pssm-ID: 182034 [Multi-domain]  Cd Length: 302  Bit Score: 79.26  E-value: 1.49e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502954518  85 VSLGVDIGVSWIRMMGLGLGGEEL-FRKQFELDVPALS-SEEVFSLVGNELNLFVSNLSsravifAVTVSVPGLVDSDNG 162
Cdd:PRK09698   5 VVLGIDMGGTHIRFCLVDAEGEILhCEKKRTAEVIAPDlVSGLGEMIDEYLRRFNARCH------GIVMGFPALVSKDRR 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502954518 163 SVIYAPNLDWTNVD-----------------VCQQVNRVIQFSVKSIEVHNEANMAAlahtwkrpgcpsgldtfaYIsgG 225
Cdd:PRK09698  79 TVISTPNLPLTALDlydladklentlncpvfFSRDVNLQLLWDVKENNLTQQLVLGA------------------YL--G 138

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502954518 226 VGVGAAVIENRQLYLGRHGWVGEIGHLTIDPRGIQCKCGAQGCLERYVGRQALE----------------IRSGDNAALV 289
Cdd:PRK09698 139 TGMGFAVWMNGAPWTGAHGVAGELGHIPLGDMTQHCGCGNPGCLETNCSGMALRrwyeqqprdyplsdlfVHAGDHPFIQ 218

                        250       260
                 ....*....|....*....|....*....
gi 502954518 290 ESARALGMALAALTNILDVSLIIIGGDVT 318
Cdd:PRK09698 219 SLLENLARAIATSINLFDPDAIILGGGVM 247
ASKHA_NBD_ROK_EcFRK-like cd24066
nucleotide-binding domain (NBD) of Escherichia coli fructokinase (FRK) and similar proteins; ...
 87-360 3.76e-16

nucleotide-binding domain (NBD) of Escherichia coli fructokinase (FRK) and similar proteins; Escherichia coli FRK (EC 2.7.1.4), also called D-fructose kinase, manno(fructo)kinase, or MAK, catalyzes the phosphorylation of fructose to fructose-6-phosphate. It has also low level glucokinase activity in vitro. It is not able to phosphorylate D-ribose, D-mannitol, D-sorbitol, inositol, and L-threonine. Members of this subfamily belong to the kinase (ROK) family, a group of proteins that have sugar kinase and/or transcriptional repressor activities.


Pssm-ID: 466916 [Multi-domain]  Cd Length: 294  Bit Score: 78.01  E-value: 3.76e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502954518  87 LGVDIGVSWIRMMGLGLGGEELFRKQfeLDVPALSSEEVFSLVGNelnlFVSNLSSRA-VIFAVTVSVPGLVDSDNGSVI 165
Cdd:cd24066    2 IGIDLGGTKIEGIALDRAGRELLRRR--VPTPRGDYEATLDAIAD----LVEEAEEELgAPATVGIGTPGSISPRTGLVK 75

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502954518 166 YApNLDWTN-----VDVCQQVNRviqfsvkSIEVHNEANMAALAHTwkRPGCPSGLDT-FAYISGgVGVGAAVIENRQLY 239
Cdd:cd24066   76 NA-NSTWLNgkplkADLEARLGR-------PVRIENDANCFALSEA--TDGAGAGAGVvFGVILG-TGVGGGIVVNGRVL 144

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502954518 240 LGRHGWVGEIGHLTIDPR------GIQCKCGAQGCLERYVGRQALE-------------------IRSGDNAA---LVES 291
Cdd:cd24066  145 TGANGIAGEWGHNPLPWPdedelpGPPCYCGKRGCVETFLSGPALErdyarltgktlsaeeivalARAGDAAAvatLDRF 224

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502954518 292 ARALGMALAALTNILDVSLIIIGGDVTNLFADYSEEVKRLMRlHTIADEQRSlQITGSAYEMPA-VRGAA 360
Cdd:cd24066  225 LDRLGRALANVINILDPDVIVLGGGLSNIDELYTEGPAALAR-YVFSDEVET-PIVKNKHGDSSgVRGAA 292
ASKHA_NBD_ROK_EcNanK-like cd24069
nucleotide-binding domain (NBD) of Escherichia coli N-acetylmannosamine kinase and similar ...
 190-317 3.59e-14

nucleotide-binding domain (NBD) of Escherichia coli N-acetylmannosamine kinase and similar proteins; N-acetylmannosamine kinase (NanK; EC 2.7.1.60), also called ManNAc kinase, or N-acetyl-D-mannosamine kinase, catalyzes the phosphorylation of N-acetylmannosamine (ManNAc) to ManNAc-6-P. It has also low level glucokinase activity in vitro. This subfamily also contains Brucella melitensis bifunctional enzyme NanE/NanK (EC 5.1.3.9/EC 2.7.1.60), which also converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P). Members of this subfamily belong to the kinase (ROK) family, a group of proteins that have sugar kinase and/or transcriptional repressor activities.


Pssm-ID: 466919 [Multi-domain]  Cd Length: 283  Bit Score: 71.93  E-value: 3.59e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502954518 190 KSIEVHNEANMAALAHTWKRPGcpSGLDTFAYISGGVGVGAAVIENRQLYLGRHGWVGEIGHLTIDPRGIQCKCGAQGCL 269
Cdd:cd24069   94 VPVVLLNDAQAAAWGEYQAGDG--EGVGNLVFITVSTGVGGGLVLNGQLLTGPNGLAGHIGHTLADPPGPVCGCGRRGCV 171

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502954518 270 E-----RYVGRQALEI--------------RSGDNAA--LVE-SARALGMALAALTNILDVSLIIIGGDV 317
Cdd:cd24069  172 EaiasgTAIAAAASEIlgepvdakdvferaRSGDEEAarLIDrAARALADLIADLKATLDLDCVVIGGSV 241
PRK09557 PRK09557
fructokinase; Reviewed
 87-360 5.35e-13

fructokinase; Reviewed


Pssm-ID: 236565 [Multi-domain]  Cd Length: 301  Bit Score: 68.90  E-value: 5.35e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502954518  87 LGVDIGVSWIRMMGLGLGGEELFRKQfeLDVPALSSEEVFSLVGNELNLFVSNLSSRAvifAVTVSVPGLVDSDNGSVIY 166
Cdd:PRK09557   3 IGIDLGGTKIEVIALDDAGEELFRKR--LPTPRDDYQQTIEAIATLVDMAEQATGQRG---TVGVGIPGSISPYTGLVKN 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502954518 167 ApNLDWTN-----VDVCQQVNRviqfsvkSIEVHNEANMAALAHTWKRPGCPSGLdTFAYISGgVGVGAAVIENRQLYLG 241
Cdd:PRK09557  78 A-NSTWLNgqpldKDLSARLNR-------EVRLANDANCLAVSEAVDGAAAGKQT-VFAVIIG-TGCGAGVAINGRVHIG 147

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502954518 242 RHGWVGEIGH-----LTIDPRG----IQCKCGAQGCLERYV------------GRQAL---EIRS----GD---NAALVE 290
Cdd:PRK09557 148 GNGIAGEWGHnplpwMDEDELRyrneVPCYCGKQGCIETFIsgtgfatdyrrlSGKALkgsEIIRlveeGDpvaELAFRR 227

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502954518 291 SARALGMALAALTNILDVSLIIIGGDVTNLFADYsEEVKRLMRLHTIADEQRSLQITGSAYEMPAVRGAA 360
Cdd:PRK09557 228 YEDRLAKSLAHVINILDPDVIVLGGGMSNVDRLY-PTLPALLKQYVFGGECETPVRKALHGDSSGVRGAA 296
ASKHA_NBD_ROK_NAGK cd24057
nucleotide-binding domain (NBD) of N-acetyl-D-glucosamine kinase (NAGK) and similar proteins; ...
 149-362 2.64e-12

nucleotide-binding domain (NBD) of N-acetyl-D-glucosamine kinase (NAGK) and similar proteins; NAGK (EC 2.7.1.59), also called GlcNAc kinase, catalyzes the phosphorylation of N-acetyl-D-glucosamine (GlcNAc) derived from cell-wall degradation, yielding GlcNAc-6-P. Members of this subfamily belong to the kinase (ROK) family, a group of proteins that have sugar kinase and/or transcriptional repressor activities.


Pssm-ID: 466907 [Multi-domain]  Cd Length: 298  Bit Score: 66.87  E-value: 2.64e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502954518 149 VTVSVPGLVDSDNGSVIYApnldwtNVDVCQQVNRVIQFSVK---SIEVHNEANMAALAHTWkrPGCPSGLDTFAYISGG 225
Cdd:cd24057   60 VGIGIPGVIDPEDGTLITA------NIPAAKGRPLRADLSARlgrPVRIDNDANCFALSEAW--DGAGRGYPSVFGLILG 131

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502954518 226 VGVGAAVIENRQLYLGRHGWVGEIGH------LTIDPRGI---QCKCGAQGCLERYVG---------------RQALEI- 280
Cdd:cd24057  132 TGVGGGLVVNGRLVGGRSGIAGEWGHgplpadALLLGYDLpvlRCGCGQTGCLETYLSgrglerlyahlygeeLDAPEIi 211

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502954518 281 ---RSGDNAALVESAR---ALGMALAALTNILDVSLIIIGGDVTNLFADYSEEVKRLmRLHTIADEQRSLQITGSAYEMP 354
Cdd:cd24057  212 aawAAGDPQAVAHVDRwldLLAGCLANILTALDPDVVVLGGGLSNFPALIAELPAAL-PAHLLSGARTPRIVPARHGDAG 290


                 ....*...
gi 502954518 355 AVRGAAIQ 362
Cdd:cd24057  291 GVRGAAFL 298
PRK05082 PRK05082
N-acetylmannosamine kinase; Provisional
 219-317 4.17e-12

N-acetylmannosamine kinase; Provisional


Pssm-ID: 235338 [Multi-domain]  Cd Length: 291  Bit Score: 66.09  E-value: 4.17e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502954518 219 FAYISGGVGVGAAVIENRQLYLGRHGWVGEIGHLTIDPRGIQCKCGAQGCLE-----RYVGRQALE-------------I 280
Cdd:PRK05082 124 MVFITVSTGVGGGIVLNGKLLTGPGGLAGHIGHTLADPHGPVCGCGRRGCVEaiasgRAIAAAAQGwlagcdaktiferA 203

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|
gi 502954518 281 RSGDNAA--LVE-SARALGMALAALTNILDVSLIIIGGDV 317
Cdd:PRK05082 204 GQGDEQAqaLINrSAQAIARLIADLKATLDCQCVVLGGSV 243
PRK13310 PRK13310
N-acetyl-D-glucosamine kinase; Provisional
 149-331 1.53e-10

N-acetyl-D-glucosamine kinase; Provisional


Pssm-ID: 183967 [Multi-domain]  Cd Length: 303  Bit Score: 61.54  E-value: 1.53e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502954518 149 VTVSVPGLVDSDNGSViYAPNLD-WTNVDVCQQVNRVIQFSVKsieVHNEANMAALAHTWKrpgcpSGLDTFAYISG--- 224
Cdd:PRK13310  60 VGIGIPGMPETEDGTL-YAANVPaASGKPLRADLSARLGRDVR---LDNDANCFALSEAWD-----DEFTQYPLVMGlil 130

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502954518 225 GVGVGAAVIENRQLYLGRHGWVGEIGH--LTID---------PRgIQCKCGAQGCLERYV-GR--------------QAL 278
Cdd:PRK13310 131 GTGVGGGLVFNGKPISGRSYITGEFGHmrLPVDaltllgwdaPL-RRCGCGQKGCIENYLsGRgfewlyqhyygeplQAP 209

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 502954518 279 EI----RSGDNAALVESARALGMALAALTNI---LDVSLIIIGGDVTNLFADYSEEVKRL 331
Cdd:PRK13310 210 EIialyYQGDEQAVAHVERYLDLLAICLGNIltiVDPHLVVLGGGLSNFDAIYEQLPKRL 269
PRK13311 PRK13311
N-acetyl-D-glucosamine kinase; Provisional
 148-279 1.57e-10

N-acetyl-D-glucosamine kinase; Provisional


Pssm-ID: 106271 [Multi-domain]  Cd Length: 256  Bit Score: 61.20  E-value: 1.57e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502954518 148 AVTVSVPGLVDSDNGSVIYAPNLDWTNVDVCQQVNRVIQfsvKSIEVHNEANMAALAHTWKrpgcpSGLDTFAYISG--- 224
Cdd:PRK13311  59 SVGIGIPGLPNADDGTVFTANVPSAMGQPLQADLSRLIQ---REVRIDNDANCFALSEAWD-----PEFRTYPTVLGlil 130

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 502954518 225 GVGVGAAVIENRQLYLGRHGWVGEIGH--LTID---------PRgIQCKCGAQGCLERYVGRQALE 279
Cdd:PRK13311 131 GTGVGGGLIVNGSIVSGRNHITGEFGHfrLPVDaldilgadiPR-VPCGCGHRGCIENYISGRGFE 195
ASKHA_NBD_ROK_PPGK cd24058
nucleotide-binding domain (NBD) of polyphosphate glucokinase (PPGK) and similar proteins; PPGK ...
 87-329 2.00e-06

nucleotide-binding domain (NBD) of polyphosphate glucokinase (PPGK) and similar proteins; PPGK (EC 2.7.1.63/EC 2.7.1.2), also called poly(P)/ATP-glucomannokinase (GMK), poly(P) glucokinase, ATP-dependent glucokinase, or polyphosphate--glucose phosphotransferase, catalyzes the phosphorylation of glucose using polyphosphate or ATP as the phosphoryl donor. Polyphosphate, rather than ATP, seems to be the major phosphate donor for the enzyme in Mycobacterium tuberculosis. GTP, UTP and CTP can replace ATP as phosphoryl donor. PPGK belongs to the kinase (ROK) family, a group of proteins that have sugar kinase and/or transcriptional repressor activities. Members of this family lack the cysteine-rich zinc-binding motif, which presents in other ROK families.


Pssm-ID: 466908 [Multi-domain]  Cd Length: 239  Bit Score: 48.33  E-value: 2.00e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502954518  87 LGVDIGVSWIRMMGLGLGGEELFRKQFELDVPALSSEEVFSLVGNELnlfVSNLSSRAvifAVTVSVPGLVDsdNGSVIY 166
Cdd:cd24058    2 LGIDIGGSGIKGAIVDTDTGELLSERIRIPTPQPATPEAVADVVAEL---VAHFPWFG---PVGVGFPGVVR--RGVVRT 73

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502954518 167 APNLD--WTNVDVCQQVNRVIQFSVKsieVHNEANMAALAHTwkRPG---CPSGLDTFayISGGVGVGAAVIENRQLYLG 241
Cdd:cd24058   74 AANLDksWIGFDAAKLLSKRLGRPVR---VLNDADAAGLAEM--KGGagkGEKGVVLV--LTLGTGIGSALFVDGHLVPN 146

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502954518 242 RhgwvgEIGHLTIDprgiqckcgaQGCLERYVgrqALEIRSGDNAALVESARALGMALAALTNILDVSLIIIGGDVTNLF 321
Cdd:cd24058  147 T-----ELGHLEIR----------GKDAEERA---SLGVRAREDLGWKRWAKRVNKYLQYLERLFNPDLFIIGGGNSKKA 208


                 ....*...
gi 502954518 322 ADYSEEVK 329
Cdd:cd24058  209 DKFLPLLD 216
ASKHA_NBD_ROK_BsFRK-like cd24067
nucleotide-binding domain (NBD) of Bacillus subtilis fructokinase (FRK) and similar proteins; ...
 199-332 3.38e-06

nucleotide-binding domain (NBD) of Bacillus subtilis fructokinase (FRK) and similar proteins; Bacillus subtilis FRK (EC 2.7.1.4), also called glucomannan utilization protein E, catalyzes the phosphorylation of fructose to fructose-6-P. It seems to be involved in the degradation of glucomannan. Members of this subfamily belong to the kinase (ROK) family, a group of proteins that have sugar kinase and/or transcriptional repressor activities.


Pssm-ID: 466917 [Multi-domain]  Cd Length: 285  Bit Score: 48.31  E-value: 3.38e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502954518 199 NMAALA-HTWkrpGCPSGLDTFAYISGGVGVGAAVIENRQLYLGR-HgwvGEIGH--LTIDPR--GIQCKCGAQG-CLER 271
Cdd:cd24067  106 NAAALAeYRW---GAAKGLDSLAYITVGTGIGVGLVVNGKPVHGLlH---PEMGHirVPRHPDddGFPGVCPFHGdCLEG 179

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 502954518 272 YVGRQALEIRSG--------DNAALVESARALGMALAALTNILDVSLIIIGGDVTN---LFADYSEEVKRLM 332
Cdd:cd24067  180 LASGPAIAARWGipaeelpdDHPAWDLEAYYLAQACANLTLTLSPERIVLGGGVMQrpgLFPRIREKFRKLL 251
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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