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Conserved domains on  [gi|502963071|ref|WP_013198047|]
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AraC family transcriptional regulator [Acinetobacter oleivorans]

Protein Classification

AraC family transcriptional regulator( domain architecture ID 12123318)

AraC family transcriptional regulator containing a cupin domain as its effector domain and an AraC family helix-turn-helix (HTH) DNA binding domain, controls the expression of genes with diverse biological functions including metabolism, stress response, and virulence

CATH:  2.60.120.10
Gene Ontology:  GO:0003700|GO:0006355|GO:0043565
PubMed:  11282467|33837749|9409145|12270809|19478949|14697267|9573603
SCOP:  3001825

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
HTH_ARAC smart00342
helix_turn_helix, arabinose operon control protein;
223-305 2.50e-27

helix_turn_helix, arabinose operon control protein;


:

Pssm-ID: 197666 [Multi-domain]  Cd Length: 84  Bit Score: 101.86  E-value: 2.50e-27
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502963071   223 WTVESLAEQCCMSRSKFANLFSSIIGEPPLTYLQHYRFRLASQYLRTSNLSIQQISNKVGYSSETAFSQAFKRIFDLSPK 302
Cdd:smart00342   2 LTLEDLAEALGVSPRHLQRLFKKETGTTPKQYLRDRRLERARRLLRDTDLSVTEIALRVGFSSQSYFSRAFKKLFGVTPS 81


                   ...
gi 502963071   303 QYR 305
Cdd:smart00342  82 EYR 84
AraC COG2207
AraC-type DNA-binding domain and AraC-containing proteins [Transcription];
98-308 1.20e-25

AraC-type DNA-binding domain and AraC-containing proteins [Transcription];


:

Pssm-ID: 441809 [Multi-domain]  Cd Length: 258  Bit Score: 102.94  E-value: 1.20e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502963071  98 HRQDAIEFGTSSPDNTLLLSLRCQIDTHMAGPLINALPSIMHIQHENQTTPPEWLQIGLYFLAIETQKIRPGHDKIIDHL 177
Cdd:COG2207   41 LALLLLLLLLLGLLGGLLLLLLLLLLLGLLLLLLLLLLGLLLLALLALLLLVGLLLLLLLLLLLLLLLLLLLLLLLLLLL 120

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502963071 178 VSILLIECIRDHIQQMTDQQNWLSALTHPELSNALSAIHSQPEVTW---TVESLAEQCCMSRSKFANLFSSIIGEPPLTY 254
Cdd:COG2207  121 LLLLLLLLALLRALELLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLlllTLEELARELGLSPRTLSRLFKEETGTSPKQY 200

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....
gi 502963071 255 LQHYRFRLASQYLRTSNLSIQQISNKVGYSSETAFSQAFKRIFDLSPKQYRQQY 308
Cdd:COG2207  201 LRELRLERAKRLLAETDLSISEIAYELGFSSQSHFSRAFKKRFGVTPSEYRKRL 254
Cupin_6 pfam12852
Cupin; This is a family of bacterial and eukaryotic proteins that belong to the Cupin ...
 2-190 2.38e-18

Cupin; This is a family of bacterial and eukaryotic proteins that belong to the Cupin superfamily. Some of the proteins in this family are annotated as being members of the AraC family of transcription factors, in which case this domain corresponds to the ligand binding domain.


:

Pssm-ID: 432833  Cd Length: 184  Bit Score: 81.20  E-value: 2.38e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502963071    2 DALSKFFDDIHLNKSEYIYLKAQGEWAFKTQDQSALLAYIVLTGSVYIQLNTSEKITATAGDIILIPSGKAHSATDSKST 81
Cdd:pfam12852   1 DVLSDLLAGLRLRGAVFFRGVLRAPWALRFPAGDGATFHVVLRGSCWLRLPGGEPVRLRAGDLVLLPRGDPHVLADDPGT 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502963071   82 ASKLVDSLDITSLFNGHRQDAIEFGTSspdnTLLLSLRCQIDTHMAGPLINALPSIMHIQHENQTTPpeWLQIGLYFLAI 161
Cdd:pfam12852  81 PPVPVDPLSRAPRPGEGEPVVGGGGAA----TVLLCGAFQFDGEAANPLLAALPPVLHVPADEAAAP--WLRALLELLAA 154

                         170       180
                  ....*....|....*....|....*....
gi 502963071  162 ETQKIRPGHDKIIDHLVSILLIECIRDHI 190
Cdd:pfam12852 155 ELAEDRPGSQAVLDRLLDLLLVQALRAWL 183
 
Name Accession Description Interval E-value
HTH_ARAC smart00342
helix_turn_helix, arabinose operon control protein;
223-305 2.50e-27

helix_turn_helix, arabinose operon control protein;


Pssm-ID: 197666 [Multi-domain]  Cd Length: 84  Bit Score: 101.86  E-value: 2.50e-27
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502963071   223 WTVESLAEQCCMSRSKFANLFSSIIGEPPLTYLQHYRFRLASQYLRTSNLSIQQISNKVGYSSETAFSQAFKRIFDLSPK 302
Cdd:smart00342   2 LTLEDLAEALGVSPRHLQRLFKKETGTTPKQYLRDRRLERARRLLRDTDLSVTEIALRVGFSSQSYFSRAFKKLFGVTPS 81


                   ...
gi 502963071   303 QYR 305
Cdd:smart00342  82 EYR 84
AraC COG2207
AraC-type DNA-binding domain and AraC-containing proteins [Transcription];
98-308 1.20e-25

AraC-type DNA-binding domain and AraC-containing proteins [Transcription];


Pssm-ID: 441809 [Multi-domain]  Cd Length: 258  Bit Score: 102.94  E-value: 1.20e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502963071  98 HRQDAIEFGTSSPDNTLLLSLRCQIDTHMAGPLINALPSIMHIQHENQTTPPEWLQIGLYFLAIETQKIRPGHDKIIDHL 177
Cdd:COG2207   41 LALLLLLLLLLGLLGGLLLLLLLLLLLGLLLLLLLLLLGLLLLALLALLLLVGLLLLLLLLLLLLLLLLLLLLLLLLLLL 120

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502963071 178 VSILLIECIRDHIQQMTDQQNWLSALTHPELSNALSAIHSQPEVTW---TVESLAEQCCMSRSKFANLFSSIIGEPPLTY 254
Cdd:COG2207  121 LLLLLLLLALLRALELLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLlllTLEELARELGLSPRTLSRLFKEETGTSPKQY 200

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....
gi 502963071 255 LQHYRFRLASQYLRTSNLSIQQISNKVGYSSETAFSQAFKRIFDLSPKQYRQQY 308
Cdd:COG2207  201 LRELRLERAKRLLAETDLSISEIAYELGFSSQSHFSRAFKKRFGVTPSEYRKRL 254
GlxA COG4977
Transcriptional regulator GlxA, contains an amidase domain and an AraC-type DNA-binding HTH ...
 205-308 3.85e-25

Transcriptional regulator GlxA, contains an amidase domain and an AraC-type DNA-binding HTH domain [Transcription];


Pssm-ID: 444002 [Multi-domain]  Cd Length: 318  Bit Score: 102.54  E-value: 3.85e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502963071 205 HPELSNALSAIHSQPEVTWTVESLAEQCCMSRSKFANLFSSIIGEPPLTYLQHYRFRLASQYLRTSNLSIQQISNKVGYS 284
Cdd:COG4977  209 DPRLARAQAWMEANLEEPLSVDELARRAGMSPRTLERRFRAATGTTPARYLQRLRLERARRLLETTDLSIEEIAAACGFG 288

                         90       100
                 ....*....|....*....|....
gi 502963071 285 SETAFSQAFKRIFDLSPKQYRQQY 308
Cdd:COG4977  289 SASHFRRAFRRRFGVSPSAYRRRF 312
HTH_18 pfam12833
Helix-turn-helix domain;
228-307 2.59e-21

Helix-turn-helix domain;


Pssm-ID: 432818 [Multi-domain]  Cd Length: 81  Bit Score: 86.10  E-value: 2.59e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502963071  228 LAEQCCMSRSKFANLFSSIIGEPPLTYLQHYRFRLASQYL-RTSNLSIQQISNKVGYSSETAFSQAFKRIFDLSPKQYRQ 306
Cdd:pfam12833   1 LAAALGMSPRTLSRLFKRELGLSPKEYLRRLRLERARRLLlEDTGLSVAEIALALGFSDASHFSRAFRRLFGLTPSEYRR 80


                  .
gi 502963071  307 Q 307
Cdd:pfam12833  81 R 81
Cupin_6 pfam12852
Cupin; This is a family of bacterial and eukaryotic proteins that belong to the Cupin ...
 2-190 2.38e-18

Cupin; This is a family of bacterial and eukaryotic proteins that belong to the Cupin superfamily. Some of the proteins in this family are annotated as being members of the AraC family of transcription factors, in which case this domain corresponds to the ligand binding domain.


Pssm-ID: 432833  Cd Length: 184  Bit Score: 81.20  E-value: 2.38e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502963071    2 DALSKFFDDIHLNKSEYIYLKAQGEWAFKTQDQSALLAYIVLTGSVYIQLNTSEKITATAGDIILIPSGKAHSATDSKST 81
Cdd:pfam12852   1 DVLSDLLAGLRLRGAVFFRGVLRAPWALRFPAGDGATFHVVLRGSCWLRLPGGEPVRLRAGDLVLLPRGDPHVLADDPGT 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502963071   82 ASKLVDSLDITSLFNGHRQDAIEFGTSspdnTLLLSLRCQIDTHMAGPLINALPSIMHIQHENQTTPpeWLQIGLYFLAI 161
Cdd:pfam12852  81 PPVPVDPLSRAPRPGEGEPVVGGGGAA----TVLLCGAFQFDGEAANPLLAALPPVLHVPADEAAAP--WLRALLELLAA 154

                         170       180
                  ....*....|....*....|....*....
gi 502963071  162 ETQKIRPGHDKIIDHLVSILLIECIRDHI 190
Cdd:pfam12852 155 ELAEDRPGSQAVLDRLLDLLLVQALRAWL 183
ftrA PRK09393
transcriptional activator FtrA; Provisional
 208-308 9.21e-18

transcriptional activator FtrA; Provisional


Pssm-ID: 181818 [Multi-domain]  Cd Length: 322  Bit Score: 82.32  E-value: 9.21e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502963071 208 LSNALSAIHSQPEVTWTVESLAEQCCMSRSKFANLFSSIIGEPPLTYLQHYRFRLASQYLRTSNLSIQQISNKVGYSSET 287
Cdd:PRK09393 220 LGPLIDWMRAHLAEPHTVASLAARAAMSPRTFLRRFEAATGMTPAEWLLRERLARARDLLESSALSIDQIAERAGFGSEE 299

                         90       100
                 ....*....|....*....|.
gi 502963071 288 AFSQAFKRIFDLSPKQYRQQY 308
Cdd:PRK09393 300 SLRHHFRRRAATSPAAYRKRF 320
viru_reg_Rsp NF033869
AraC family transcriptional regulator Rsp; Rsp (repressor of surface proteins), as described ...
 172-307 8.87e-12

AraC family transcriptional regulator Rsp; Rsp (repressor of surface proteins), as described in Staphylococcus aureus, is a large protein with an AraC-like helix-turn-helix DNA-binding domain. Regulatory targets include the accessory gene regulator (agr) operon, which in turn regulates a large number of virulence factors.


Pssm-ID: 411433 [Multi-domain]  Cd Length: 701  Bit Score: 65.51  E-value: 8.87e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502963071 172 KIIDHLVSILLIECIRDHIQQMtdqqnwlsALTHPELSNALSAIHSQPEVTWTVESLAEQCCMSRSKFANLFSSIIGEPP 251
Cdd:NF033869 121 KIIQTLYKEAVVRHPHLYIPNI--------AVNNPVFINCLTFIHDHISSNLSLRDVAQHCNISESYCSNLFVRYLNMNF 192

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 502963071 252 LTYLQHYRFRLASQYLRTSNLSIQQISNKVGYSSETAFSQAFKRIFDLSPKQYRQQ 307
Cdd:NF033869 193 KDYFTSLKLCHAIQLLLSTNHSINAISELSGFSSHTNFTNQFKNYLNFSPKQFRTL 248
cupin_YkgD-like_N cd06995
AraC/XylS family transcriptional regulators similar to Escherichia coli YkgD, N-terminal cupin ...
 24-99 2.11e-06

AraC/XylS family transcriptional regulators similar to Escherichia coli YkgD, N-terminal cupin domain; This family contains mostly bacterial proteins containing an AraC/XylS family helix-turn-helix (HTH) DNA-binding domain C-terminal to a cupin domain, and may be possible transcriptional regulators. Included in this family is YkgD, an uncharacterized Escherichia coli protein thought to be a transcriptional regulator. Proteins in this family belong to the cupin superfamily with a conserved "jelly roll-like" beta-barrel fold capable of homodimerization.


Pssm-ID: 380399  Cd Length: 114  Bit Score: 45.79  E-value: 2.11e-06
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 502963071  24 QGEWAFKTQDQSALLA--YIVLTGSVYIQLNTSEKITATAGDIILIPSGKAHSATDSKSTASKLVDSLDITSLFNGHR 99
Cdd:cd06995   23 QGDWQLDHPAGPLGEArfHIVLQGECRLELPGGESLTLSPGDVVLLPQGSAHRLHSGSNKDAAVPPTLSSDGLLPLRR 100
QdoI COG1917
Cupin domain protein related to quercetin dioxygenase [General function prediction only];
40-87 1.52e-03

Cupin domain protein related to quercetin dioxygenase [General function prediction only];


Pssm-ID: 441521 [Multi-domain]  Cd Length: 99  Bit Score: 37.52  E-value: 1.52e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*...
gi 502963071  40 YIVLTGSVYIQLNtSEKITATAGDIILIPSGKAHSATDSKSTASKLVD 87
Cdd:COG1917   47 IYVLEGEGEVEVG-GEEYELKPGDVVFIPPGVPHAFRNLGDEPAVLLV 93
 
Name Accession Description Interval E-value
HTH_ARAC smart00342
helix_turn_helix, arabinose operon control protein;
223-305 2.50e-27

helix_turn_helix, arabinose operon control protein;


Pssm-ID: 197666 [Multi-domain]  Cd Length: 84  Bit Score: 101.86  E-value: 2.50e-27
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502963071   223 WTVESLAEQCCMSRSKFANLFSSIIGEPPLTYLQHYRFRLASQYLRTSNLSIQQISNKVGYSSETAFSQAFKRIFDLSPK 302
Cdd:smart00342   2 LTLEDLAEALGVSPRHLQRLFKKETGTTPKQYLRDRRLERARRLLRDTDLSVTEIALRVGFSSQSYFSRAFKKLFGVTPS 81


                   ...
gi 502963071   303 QYR 305
Cdd:smart00342  82 EYR 84
AraC COG2207
AraC-type DNA-binding domain and AraC-containing proteins [Transcription];
98-308 1.20e-25

AraC-type DNA-binding domain and AraC-containing proteins [Transcription];


Pssm-ID: 441809 [Multi-domain]  Cd Length: 258  Bit Score: 102.94  E-value: 1.20e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502963071  98 HRQDAIEFGTSSPDNTLLLSLRCQIDTHMAGPLINALPSIMHIQHENQTTPPEWLQIGLYFLAIETQKIRPGHDKIIDHL 177
Cdd:COG2207   41 LALLLLLLLLLGLLGGLLLLLLLLLLLGLLLLLLLLLLGLLLLALLALLLLVGLLLLLLLLLLLLLLLLLLLLLLLLLLL 120

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502963071 178 VSILLIECIRDHIQQMTDQQNWLSALTHPELSNALSAIHSQPEVTW---TVESLAEQCCMSRSKFANLFSSIIGEPPLTY 254
Cdd:COG2207  121 LLLLLLLLALLRALELLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLlllTLEELARELGLSPRTLSRLFKEETGTSPKQY 200

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....
gi 502963071 255 LQHYRFRLASQYLRTSNLSIQQISNKVGYSSETAFSQAFKRIFDLSPKQYRQQY 308
Cdd:COG2207  201 LRELRLERAKRLLAETDLSISEIAYELGFSSQSHFSRAFKKRFGVTPSEYRKRL 254
GlxA COG4977
Transcriptional regulator GlxA, contains an amidase domain and an AraC-type DNA-binding HTH ...
 205-308 3.85e-25

Transcriptional regulator GlxA, contains an amidase domain and an AraC-type DNA-binding HTH domain [Transcription];


Pssm-ID: 444002 [Multi-domain]  Cd Length: 318  Bit Score: 102.54  E-value: 3.85e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502963071 205 HPELSNALSAIHSQPEVTWTVESLAEQCCMSRSKFANLFSSIIGEPPLTYLQHYRFRLASQYLRTSNLSIQQISNKVGYS 284
Cdd:COG4977  209 DPRLARAQAWMEANLEEPLSVDELARRAGMSPRTLERRFRAATGTTPARYLQRLRLERARRLLETTDLSIEEIAAACGFG 288

                         90       100
                 ....*....|....*....|....
gi 502963071 285 SETAFSQAFKRIFDLSPKQYRQQY 308
Cdd:COG4977  289 SASHFRRAFRRRFGVSPSAYRRRF 312
HTH_18 pfam12833
Helix-turn-helix domain;
228-307 2.59e-21

Helix-turn-helix domain;


Pssm-ID: 432818 [Multi-domain]  Cd Length: 81  Bit Score: 86.10  E-value: 2.59e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502963071  228 LAEQCCMSRSKFANLFSSIIGEPPLTYLQHYRFRLASQYL-RTSNLSIQQISNKVGYSSETAFSQAFKRIFDLSPKQYRQ 306
Cdd:pfam12833   1 LAAALGMSPRTLSRLFKRELGLSPKEYLRRLRLERARRLLlEDTGLSVAEIALALGFSDASHFSRAFRRLFGLTPSEYRR 80


                  .
gi 502963071  307 Q 307
Cdd:pfam12833  81 R 81
Cupin_6 pfam12852
Cupin; This is a family of bacterial and eukaryotic proteins that belong to the Cupin ...
 2-190 2.38e-18

Cupin; This is a family of bacterial and eukaryotic proteins that belong to the Cupin superfamily. Some of the proteins in this family are annotated as being members of the AraC family of transcription factors, in which case this domain corresponds to the ligand binding domain.


Pssm-ID: 432833  Cd Length: 184  Bit Score: 81.20  E-value: 2.38e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502963071    2 DALSKFFDDIHLNKSEYIYLKAQGEWAFKTQDQSALLAYIVLTGSVYIQLNTSEKITATAGDIILIPSGKAHSATDSKST 81
Cdd:pfam12852   1 DVLSDLLAGLRLRGAVFFRGVLRAPWALRFPAGDGATFHVVLRGSCWLRLPGGEPVRLRAGDLVLLPRGDPHVLADDPGT 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502963071   82 ASKLVDSLDITSLFNGHRQDAIEFGTSspdnTLLLSLRCQIDTHMAGPLINALPSIMHIQHENQTTPpeWLQIGLYFLAI 161
Cdd:pfam12852  81 PPVPVDPLSRAPRPGEGEPVVGGGGAA----TVLLCGAFQFDGEAANPLLAALPPVLHVPADEAAAP--WLRALLELLAA 154

                         170       180
                  ....*....|....*....|....*....
gi 502963071  162 ETQKIRPGHDKIIDHLVSILLIECIRDHI 190
Cdd:pfam12852 155 ELAEDRPGSQAVLDRLLDLLLVQALRAWL 183
ftrA PRK09393
transcriptional activator FtrA; Provisional
 208-308 9.21e-18

transcriptional activator FtrA; Provisional


Pssm-ID: 181818 [Multi-domain]  Cd Length: 322  Bit Score: 82.32  E-value: 9.21e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502963071 208 LSNALSAIHSQPEVTWTVESLAEQCCMSRSKFANLFSSIIGEPPLTYLQHYRFRLASQYLRTSNLSIQQISNKVGYSSET 287
Cdd:PRK09393 220 LGPLIDWMRAHLAEPHTVASLAARAAMSPRTFLRRFEAATGMTPAEWLLRERLARARDLLESSALSIDQIAERAGFGSEE 299

                         90       100
                 ....*....|....*....|.
gi 502963071 288 AFSQAFKRIFDLSPKQYRQQY 308
Cdd:PRK09393 300 SLRHHFRRRAATSPAAYRKRF 320
AdaA COG2169
Methylphosphotriester-DNA--protein-cysteine methyltransferase (N-terminal fragment of Ada), ...
 200-314 1.87e-15

Methylphosphotriester-DNA--protein-cysteine methyltransferase (N-terminal fragment of Ada), contains Zn-binding and two AraC-type DNA-binding domains [Replication, recombination and repair];


Pssm-ID: 441772 [Multi-domain]  Cd Length: 358  Bit Score: 75.86  E-value: 1.87e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502963071 200 LSALTHPELSNALSAIHSQPEVTWTVESLAEQCCMSRSKFANLFSSIIGEPPLTYLQHYRFRLASQYLRTSnLSIQQISN 279
Cdd:COG2169   78 GSPPRADLVARACRLIEAGAEDRPSLEDLAARLGLSPRHLRRLFKAHTGVTPKAYARARRLLRARQLLQTG-LSVTDAAY 156

                         90       100       110
                 ....*....|....*....|....*....|....*
gi 502963071 280 KVGYSSETAFSQAFKRIFDLSPKQYRQQYIGHSLD 314
Cdd:COG2169  157 AAGFGSLSRFYEAFKKLLGMTPSAYRRGGAGAAIR 191
viru_reg_Rsp NF033869
AraC family transcriptional regulator Rsp; Rsp (repressor of surface proteins), as described ...
 172-307 8.87e-12

AraC family transcriptional regulator Rsp; Rsp (repressor of surface proteins), as described in Staphylococcus aureus, is a large protein with an AraC-like helix-turn-helix DNA-binding domain. Regulatory targets include the accessory gene regulator (agr) operon, which in turn regulates a large number of virulence factors.


Pssm-ID: 411433 [Multi-domain]  Cd Length: 701  Bit Score: 65.51  E-value: 8.87e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502963071 172 KIIDHLVSILLIECIRDHIQQMtdqqnwlsALTHPELSNALSAIHSQPEVTWTVESLAEQCCMSRSKFANLFSSIIGEPP 251
Cdd:NF033869 121 KIIQTLYKEAVVRHPHLYIPNI--------AVNNPVFINCLTFIHDHISSNLSLRDVAQHCNISESYCSNLFVRYLNMNF 192

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 502963071 252 LTYLQHYRFRLASQYLRTSNLSIQQISNKVGYSSETAFSQAFKRIFDLSPKQYRQQ 307
Cdd:NF033869 193 KDYFTSLKLCHAIQLLLSTNHSINAISELSGFSSHTNFTNQFKNYLNFSPKQFRTL 248
PRK10572 PRK10572
arabinose operon transcriptional regulator AraC;
224-308 7.21e-09

arabinose operon transcriptional regulator AraC;


Pssm-ID: 236717 [Multi-domain]  Cd Length: 290  Bit Score: 55.75  E-value: 7.21e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502963071 224 TVESLAEQCCMSRSKFANLFSSIIGEPPLTYLQHYRFRLASQYLRTSNLSIQQISNKVGYSSETAFSQAFKRIFDLSPKQ 303
Cdd:PRK10572 201 DIESVAQHVCLSPSRLAHLFRQQLGISVLRWREDQRISRAKLLLQTTRMPIATIGRNVGYDDQLYFSRVFKKCTGASPSE 280


                 ....*
gi 502963071 304 YRQQY 308
Cdd:PRK10572 281 FRARC 285
PRK10219 PRK10219
superoxide response transcriptional regulator SoxS;
203-307 4.16e-08

superoxide response transcriptional regulator SoxS;


Pssm-ID: 182314 [Multi-domain]  Cd Length: 107  Bit Score: 50.69  E-value: 4.16e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502963071 203 LTHPELSNALSA-IHSQPEVTWTVESLAEQCCMSRSKFANLFSSIIGEPPLTYLQHYRFRLASQYLRTSNLSIQQISNKV 281
Cdd:PRK10219   1 MSHQKIIQTLIAwIDEHIDQPLNIDVVAKKSGYSKWYLQRMFRTVTHQTLGDYIRQRRLLLAAVELRTTERPIFDIAMDL 80

                         90       100
                 ....*....|....*....|....*.
gi 502963071 282 GYSSETAFSQAFKRIFDLSPKQYRQQ 307
Cdd:PRK10219  81 GYVSQQTFSRVFRRQFDRTPSDYRHR 106
PRK09685 PRK09685
DNA-binding transcriptional activator FeaR; Provisional
 177-308 6.84e-07

DNA-binding transcriptional activator FeaR; Provisional


Pssm-ID: 236612 [Multi-domain]  Cd Length: 302  Bit Score: 50.03  E-value: 6.84e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502963071 177 LVSILLIECIRDHIQQMTDQ---QNWLSALTHP--------------ELSNALSAIH---SQPEVTwtVESLAEQCCMSR 236
Cdd:PRK09685 151 LSHRLLQQSMNGPALSETESealLEALIALLRPalhqresvqprrerQFQKVVALIDqsiQEEILR--PEWIAGELGISV 228

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 502963071 237 SKFANLFSSIiGEPPLTYLQHYRFRLASQYLRT--SNLSIQQISNKVGYSSETAFSQAFKRIFDLSPKQYRQQY 308
Cdd:PRK09685 229 RSLYRLFAEQ-GLVVAQYIRNRRLDRCADDLRPaaDDEKITSIAYKWGFSDSSHFSTAFKQRFGVSPGEYRRKF 301
cupin_YkgD-like_N cd06995
AraC/XylS family transcriptional regulators similar to Escherichia coli YkgD, N-terminal cupin ...
 24-99 2.11e-06

AraC/XylS family transcriptional regulators similar to Escherichia coli YkgD, N-terminal cupin domain; This family contains mostly bacterial proteins containing an AraC/XylS family helix-turn-helix (HTH) DNA-binding domain C-terminal to a cupin domain, and may be possible transcriptional regulators. Included in this family is YkgD, an uncharacterized Escherichia coli protein thought to be a transcriptional regulator. Proteins in this family belong to the cupin superfamily with a conserved "jelly roll-like" beta-barrel fold capable of homodimerization.


Pssm-ID: 380399  Cd Length: 114  Bit Score: 45.79  E-value: 2.11e-06
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 502963071  24 QGEWAFKTQDQSALLA--YIVLTGSVYIQLNTSEKITATAGDIILIPSGKAHSATDSKSTASKLVDSLDITSLFNGHR 99
Cdd:cd06995   23 QGDWQLDHPAGPLGEArfHIVLQGECRLELPGGESLTLSPGDVVLLPQGSAHRLHSGSNKDAAVPPTLSSDGLLPLRR 100
HTH_AraC pfam00165
Bacterial regulatory helix-turn-helix proteins, AraC family; In the absence of arabinose, the ...
 269-306 2.71e-06

Bacterial regulatory helix-turn-helix proteins, AraC family; In the absence of arabinose, the N-terminal arm of AraC binds to the DNA binding domain (pfam00165) and helps to hold the two DNA binding domains in a relative orientation that favours DNA looping. In the presence of arabinose, the arms bind over the arabinose on the dimerization domain, thus freeing the DNA-binding domains. The freed DNA-binding domains are then able to assume a conformation suitable for binding to the adjacent DNA sites that are utilized when AraC activates transcription, and hence AraC ceases looping the DNA when arabinose is added.


Pssm-ID: 425497 [Multi-domain]  Cd Length: 42  Bit Score: 43.68  E-value: 2.71e-06
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 502963071  269 TSNLSIQQISNKVGYSSETaFSQAFKRIFDLSPKQYRQ 306
Cdd:pfam00165   6 STNLTIADIADELGFSRSY-FSRLFKKYTGVTPSQYRH 42
PRK13503 PRK13503
HTH-type transcriptional activator RhaS;
216-307 9.09e-06

HTH-type transcriptional activator RhaS;


Pssm-ID: 184094 [Multi-domain]  Cd Length: 278  Bit Score: 46.21  E-value: 9.09e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502963071 216 HSQPEVTWtvESLAEQCCMSRSKFANLFSSIIGEPPLTYLQHYRFRLASQYLRTSNLSIQQISNKVGYSSETAFSQAFKR 295
Cdd:PRK13503 183 HFAEEVNW--EALADQFSLSLRTLHRQLKQQTGLTPQRYLNRLRLLKARHLLRHSDASVTDIAYRCGFGDSNHFSTLFRR 260

                         90
                 ....*....|..
gi 502963071 296 IFDLSPKQYRQQ 307
Cdd:PRK13503 261 EFSWSPRDIRQG 272
PRK13501 PRK13501
HTH-type transcriptional activator RhaR;
212-309 2.40e-05

HTH-type transcriptional activator RhaR;


Pssm-ID: 184092 [Multi-domain]  Cd Length: 290  Bit Score: 45.28  E-value: 2.40e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502963071 212 LSAIHSQPEVTWTVESLAEQCCMSRSKFANLFSSIIGEPPLTYLQHYRFRLASQYLRTSNLSIQQISNKVGYSSETAFSQ 291
Cdd:PRK13501 182 MSALQQSLGAYFDMADFCHKNQLVERSLKQLFRQQTGMSISHYLRQIRLCHAKCLLRGSEHRISDIAARCGFEDSNYFSA 261

                         90
                 ....*....|....*...
gi 502963071 292 AFKRIFDLSPKQYRQQYI 309
Cdd:PRK13501 262 VFTREAGMTPRDYRQRFI 279
PRK15185 PRK15185
transcriptional regulator HilD; Provisional
 215-304 4.16e-05

transcriptional regulator HilD; Provisional


Pssm-ID: 185107 [Multi-domain]  Cd Length: 309  Bit Score: 44.60  E-value: 4.16e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502963071 215 IHSQPEVTWTVESLAEQCCMSRSKFANLfssiIGEPPLTYLQHY---RFRLASQYLRTSNLSIQQISNKVGYSSETAFSQ 291
Cdd:PRK15185 215 ISSSPSRQWKLTDVADHIFMSTSTLKRK----LAEEGTSFSDIYlsaRMNQAAKLLRIGNHNVNAVALKCGYDSTSYFIQ 290

                         90
                 ....*....|...
gi 502963071 292 AFKRIFDLSPKQY 304
Cdd:PRK15185 291 CFKKYFKTTPSTF 303
cupin_RmlC-like cd02208
RmlC-like cupin superfamily; This superfamily contains proteins similar to the RmlC (dTDP ...
 40-74 5.55e-05

RmlC-like cupin superfamily; This superfamily contains proteins similar to the RmlC (dTDP (deoxythymidine diphosphates)-4-dehydrorhamnose 3,5-epimerase)-like cupins. RmlC is a dTDP-sugar isomerase involved in the synthesis of L-rhamnose, a saccharide required for the virulence of some pathogenic bacteria. Cupins are a functionally diverse superfamily originally discovered based on the highly conserved motif found in germin and germin-like proteins. This conserved motif forms a beta-barrel fold found in all of the cupins, giving rise to the name cupin ('cupa' is the Latin term for small barrel). The active site of members of this superfamily is generally located at the center of a conserved barrel and usually includes a metal ion. The different functional classes in this superfamily include single domain bacterial isomerases and epimerases involved in the modification of cell wall carbohydrates, two domain bicupins such as the desiccation-tolerant seed storage globulins, and multidomain nuclear transcription factors involved in legume root nodulation.


Pssm-ID: 380338 [Multi-domain]  Cd Length: 73  Bit Score: 40.93  E-value: 5.55e-05
                         10        20        30
                 ....*....|....*....|....*....|....*
gi 502963071  40 YIVLTGSVYIQLNTSEKITATAGDIILIPSGKAHS 74
Cdd:cd02208   24 FYVLSGEGELTLDDGETVELKAGDIVLIPPGVPHS 58
PRK11511 PRK11511
MDR efflux pump AcrAB transcriptional activator MarA;
212-305 6.06e-05

MDR efflux pump AcrAB transcriptional activator MarA;


Pssm-ID: 236920 [Multi-domain]  Cd Length: 127  Bit Score: 42.01  E-value: 6.06e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502963071 212 LSAIHSQPEVTWTVESLAEQCCMSRSKFANLFSSIIGEPPLTYLQHYRFRLASQYLRTSNLSIQQISNKVGYSSETAFSQ 291
Cdd:PRK11511  15 LDWIEDNLESPLSLEKVSERSGYSKWHLQRMFKKETGHSLGQYIRSRKMTEIAQKLKESNEPILYLAERYGFESQQTLTR 94

                         90
                 ....*....|....
gi 502963071 292 AFKRIFDLSPKQYR 305
Cdd:PRK11511  95 TFKNYFDVPPHKYR 108
QdoI COG1917
Cupin domain protein related to quercetin dioxygenase [General function prediction only];
40-87 1.52e-03

Cupin domain protein related to quercetin dioxygenase [General function prediction only];


Pssm-ID: 441521 [Multi-domain]  Cd Length: 99  Bit Score: 37.52  E-value: 1.52e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*...
gi 502963071  40 YIVLTGSVYIQLNtSEKITATAGDIILIPSGKAHSATDSKSTASKLVD 87
Cdd:COG1917   47 IYVLEGEGEVEVG-GEEYELKPGDVVFIPPGVPHAFRNLGDEPAVLLV 93
PRK10296 PRK10296
DNA-binding transcriptional regulator ChbR; Provisional
 251-307 4.17e-03

DNA-binding transcriptional regulator ChbR; Provisional


Pssm-ID: 182362 [Multi-domain]  Cd Length: 278  Bit Score: 38.20  E-value: 4.17e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 502963071 251 PLTYLQHYRFRLASQYLRTSNLSIQQISNKVGYSSETAFSQAFKRIFDLSPKQYRQQ 307
Cdd:PRK10296 217 PMQIINEIRINFAKKQLEMTNYSVTDIAFEAGYSSPSLFIKTFKKLTSFTPGSYRKK 273
cupin_BLL4011-like cd02235
Bradyrhizobium diazoefficiens BLL4011 and related proteins, cupin domain; This family includes ...
 38-86 6.09e-03

Bradyrhizobium diazoefficiens BLL4011 and related proteins, cupin domain; This family includes bacterial and fungal proteins homologous to BLL4011, a Bradyrhizobium diazoefficiens protein of unknown function. Proteins in this family belong to the cupin superfamily with a conserved "jelly roll-like" beta-barrel fold capable of homodimerization.


Pssm-ID: 380363 [Multi-domain]  Cd Length: 100  Bit Score: 35.63  E-value: 6.09e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*....
gi 502963071  38 LAYiVLTGSVYIQLNTSEKITATAGDIILIPSGKAHSATDSKSTASKLV 86
Cdd:cd02235   42 SGY-VLEGSLELEVDGQPPVTLKAGDSFFIPAGTVHNAKNVGSGPAKLL 89
HTH_AraC pfam00165
Bacterial regulatory helix-turn-helix proteins, AraC family; In the absence of arabinose, the ...
 215-256 6.77e-03

Bacterial regulatory helix-turn-helix proteins, AraC family; In the absence of arabinose, the N-terminal arm of AraC binds to the DNA binding domain (pfam00165) and helps to hold the two DNA binding domains in a relative orientation that favours DNA looping. In the presence of arabinose, the arms bind over the arabinose on the dimerization domain, thus freeing the DNA-binding domains. The freed DNA-binding domains are then able to assume a conformation suitable for binding to the adjacent DNA sites that are utilized when AraC activates transcription, and hence AraC ceases looping the DNA when arabinose is added.


Pssm-ID: 425497 [Multi-domain]  Cd Length: 42  Bit Score: 34.05  E-value: 6.77e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 502963071  215 IHSQPEVTWTVESLAEQCCMSRSKFANLFSSIIGEPPLTYLQ 256
Cdd:pfam00165   1 LRENLSTNLTIADIADELGFSRSYFSRLFKKYTGVTPSQYRH 42
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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