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Conserved domains on  [gi|503035025|ref|WP_013270001|]
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MULTISPECIES: acyl carrier protein [Brevundimonas]

Protein Classification

acyl carrier protein( domain architecture ID 10011594)

acyl carrier protein may function as a carrier of the growing fatty acid chain in fatty acid biosynthesis or as the carrier of activated (amino) acid groups in polyketide synthases and non-ribosomal peptide synthases

CATH:  1.10.1200.10
Gene Ontology:  GO:0009245|GO:0000035|GO:0006633|GO:0000036
PubMed:  20662770|18059524|30543875|30787330
SCOP:  4000857

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
acpP PRK00982
acyl carrier protein; Provisional
 1-78 1.60e-31

acyl carrier protein; Provisional


:

Pssm-ID: 179197 [Multi-domain]  Cd Length: 78  Bit Score: 104.87  E-value: 1.60e-31
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 503035025  1 MSDTLERVRKIVIDHLDADPDKVTEKASFIDDLGADSLDNVELVMAFEEEFDIEIPDDAAEHIQTVGDAVKFIDEKTA 78
Cdd:PRK00982  1 MSEIFEKVKKIIVEQLGVDEEEVTPEASFVDDLGADSLDTVELVMALEEEFGIEIPDEDAEKIKTVGDAVDYIEKHQK 78
 
Name Accession Description Interval E-value
acpP PRK00982
acyl carrier protein; Provisional
 1-78 1.60e-31

acyl carrier protein; Provisional


Pssm-ID: 179197 [Multi-domain]  Cd Length: 78  Bit Score: 104.87  E-value: 1.60e-31
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 503035025  1 MSDTLERVRKIVIDHLDADPDKVTEKASFIDDLGADSLDNVELVMAFEEEFDIEIPDDAAEHIQTVGDAVKFIDEKTA 78
Cdd:PRK00982  1 MSEIFEKVKKIIVEQLGVDEEEVTPEASFVDDLGADSLDTVELVMALEEEFGIEIPDEDAEKIKTVGDAVDYIEKHQK 78
acyl_carrier TIGR00517
acyl carrier protein; This small protein has phosphopantetheine covalently bound to a Ser ...
 1-76 2.21e-24

acyl carrier protein; This small protein has phosphopantetheine covalently bound to a Ser residue. It acts as a carrier of the growing fatty acid chain, which is bound to the prosthetic group, during fatty acid biosynthesis. Homologous phosphopantetheine-binding domains are found in longer proteins. Acyl carrier proteins scoring above the noise cutoff but below the trusted cutoff may be specialized versions. These include those involved in mycolic acid biosynthesis in the Mycobacteria, lipid A biosynthesis in Rhizobium, actinorhodin polyketide synthesis in Streptomyces coelicolor, etc. This protein is not found in the Archaea.Gene name acpP.S (Ser) at position 37 in the seed alignment, in the motif DSLD, is the phosphopantetheine attachment site. [Fatty acid and phospholipid metabolism, Biosynthesis]


Pssm-ID: 213536 [Multi-domain]  Cd Length: 77  Bit Score: 86.68  E-value: 2.21e-24
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 503035025   1 MSDTLERVRKIVIDHLDADPDKVTEKASFIDDLGADSLDNVELVMAFEEEFDIEIPDDAAEHIQTVGDAVKFIDEK 76
Cdd:TIGR00517  1 MQEIFEKVKAIIKEQLNVDEDQITTDARFVEDLGADSLDTVELVMALEEEFDIEIPDEEAEKIATVGDAVNYIEEN 76
AcpP COG0236
Acyl carrier protein [Lipid transport and metabolism]; Acyl carrier protein is part of the ...
 1-78 3.16e-21

Acyl carrier protein [Lipid transport and metabolism]; Acyl carrier protein is part of the Pathway/BioSystem: Fatty acid biosynthesis


Pssm-ID: 440006 [Multi-domain]  Cd Length: 80  Bit Score: 78.74  E-value: 3.16e-21
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 503035025  1 MSDTLERVRKIVIDHLDADPDKVTEKASFIDDLGADSLDNVELVMAFEEEFDIEIPDDAAEHIQTVGDAVKFIDEKTA 78
Cdd:COG0236   3 REELEERLAEIIAEVLGVDPEEITPDDSFFEDLGLDSLDAVELIAALEEEFGIELPDTELFEYPTVADLADYLEEKLA 80
AcpM NF040636
meromycolate extension acyl carrier protein AcpM;
19-73 1.83e-08

meromycolate extension acyl carrier protein AcpM;


Pssm-ID: 468604  Cd Length: 93  Bit Score: 46.66  E-value: 1.83e-08
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....*
gi 503035025 19 DPDKVTEKASFIDDLGADSLDNVELVMAFEEEFDIEIPDDAAEHIQTVGDAVKFI 73
Cdd:NF040636 21 EPSEVTIEKSFVDDLDIDSLSMVEIAVQLEDKYGVKIPDEDLASLRTVGDAVAYV 75
PP-binding pfam00550
Phosphopantetheine attachment site; A 4'-phosphopantetheine prosthetic group is attached ...
 6-68 4.08e-07

Phosphopantetheine attachment site; A 4'-phosphopantetheine prosthetic group is attached through a serine. This prosthetic group acts as a a 'swinging arm' for the attachment of activated fatty acid and amino-acid groups. This domain forms a four helix bundle. This family includes members not included in Prosite. The inclusion of these members is supported by sequence analysis and functional evidence. The related domain of Swiss:P19828 has the attachment serine replaced by an alanine.


Pssm-ID: 425746 [Multi-domain]  Cd Length: 62  Bit Score: 42.55  E-value: 4.08e-07
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 503035025   6 ERVRKIVIDHLDADPDKVTEKASFiDDLGADSLDNVELVMAFEEEFDIEIPDDAAEHIQTVGD 68
Cdd:pfam00550  1 ERLRELLAEVLGVPAEEIDPDTDL-FDLGLDSLLAVELIARLEEEFGVEIPPSDLFEHPTLAE 62
PKS_PP smart00823
Phosphopantetheine attachment site; Phosphopantetheine (or pantetheine 4' phosphate) is the ...
 5-56 9.04e-03

Phosphopantetheine attachment site; Phosphopantetheine (or pantetheine 4' phosphate) is the prosthetic group of acyl carrier proteins (ACP) in some multienzyme complexes where it serves as a 'swinging arm' for the attachment of activated fatty acid and amino-acid groups.


Pssm-ID: 214834 [Multi-domain]  Cd Length: 86  Bit Score: 31.84  E-value: 9.04e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 503035025    5 LERVRKIVIDHLD-ADPDKVTEKASFIDdLGADSLDNVELVMAFEEEFDIEIP 56
Cdd:smart00823 14 LDLVREQVAAVLGhAAAEAIDPDRPFRD-LGLDSLMAVELRNRLEAATGLRLP 65
 
Name Accession Description Interval E-value
acpP PRK00982
acyl carrier protein; Provisional
 1-78 1.60e-31

acyl carrier protein; Provisional


Pssm-ID: 179197 [Multi-domain]  Cd Length: 78  Bit Score: 104.87  E-value: 1.60e-31
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 503035025  1 MSDTLERVRKIVIDHLDADPDKVTEKASFIDDLGADSLDNVELVMAFEEEFDIEIPDDAAEHIQTVGDAVKFIDEKTA 78
Cdd:PRK00982  1 MSEIFEKVKKIIVEQLGVDEEEVTPEASFVDDLGADSLDTVELVMALEEEFGIEIPDEDAEKIKTVGDAVDYIEKHQK 78
acyl_carrier TIGR00517
acyl carrier protein; This small protein has phosphopantetheine covalently bound to a Ser ...
 1-76 2.21e-24

acyl carrier protein; This small protein has phosphopantetheine covalently bound to a Ser residue. It acts as a carrier of the growing fatty acid chain, which is bound to the prosthetic group, during fatty acid biosynthesis. Homologous phosphopantetheine-binding domains are found in longer proteins. Acyl carrier proteins scoring above the noise cutoff but below the trusted cutoff may be specialized versions. These include those involved in mycolic acid biosynthesis in the Mycobacteria, lipid A biosynthesis in Rhizobium, actinorhodin polyketide synthesis in Streptomyces coelicolor, etc. This protein is not found in the Archaea.Gene name acpP.S (Ser) at position 37 in the seed alignment, in the motif DSLD, is the phosphopantetheine attachment site. [Fatty acid and phospholipid metabolism, Biosynthesis]


Pssm-ID: 213536 [Multi-domain]  Cd Length: 77  Bit Score: 86.68  E-value: 2.21e-24
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 503035025   1 MSDTLERVRKIVIDHLDADPDKVTEKASFIDDLGADSLDNVELVMAFEEEFDIEIPDDAAEHIQTVGDAVKFIDEK 76
Cdd:TIGR00517  1 MQEIFEKVKAIIKEQLNVDEDQITTDARFVEDLGADSLDTVELVMALEEEFDIEIPDEEAEKIATVGDAVNYIEEN 76
PTZ00171 PTZ00171
acyl carrier protein; Provisional
 2-76 3.10e-24

acyl carrier protein; Provisional


Pssm-ID: 240304  Cd Length: 148  Bit Score: 88.60  E-value: 3.10e-24
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 503035025   2 SDTLERVRKIVIDHLDADPDKVTEKASFIDDLGADSLDNVELVMAFEEEFDIEIPDDAAEHIQTVGDAVKFIDEK 76
Cdd:PTZ00171  69 EDVLTRVKKVVKNFEKVDASKITPESNFVKDLGADSLDVVELLIAIEQEFNLTIPDHDAEKIKTVQDAIDYIEQN 143
acpP CHL00124
acyl carrier protein; Validated
 1-79 9.77e-24

acyl carrier protein; Validated


Pssm-ID: 177047 [Multi-domain]  Cd Length: 82  Bit Score: 85.07  E-value: 9.77e-24
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 503035025  1 MSDTLERVRKIVIDHLDADPDKVTEKASFIDDLGADSLDNVELVMAFEEEFDIEIPDDAAEHIQTVGDAVKFIDEKTAA 79
Cdd:CHL00124  3 KNDIFEKVQSIVAEQLGIEKSEVTLDANFTRDLGADSLDVVELVMAIEEKFDIEIPDEDAEKISTLQEAVDFISQKINK 81
AcpP COG0236
Acyl carrier protein [Lipid transport and metabolism]; Acyl carrier protein is part of the ...
 1-78 3.16e-21

Acyl carrier protein [Lipid transport and metabolism]; Acyl carrier protein is part of the Pathway/BioSystem: Fatty acid biosynthesis


Pssm-ID: 440006 [Multi-domain]  Cd Length: 80  Bit Score: 78.74  E-value: 3.16e-21
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 503035025  1 MSDTLERVRKIVIDHLDADPDKVTEKASFIDDLGADSLDNVELVMAFEEEFDIEIPDDAAEHIQTVGDAVKFIDEKTA 78
Cdd:COG0236   3 REELEERLAEIIAEVLGVDPEEITPDDSFFEDLGLDSLDAVELIAALEEEFGIELPDTELFEYPTVADLADYLEEKLA 80
PRK12449 PRK12449
acyl carrier protein; Provisional
 3-78 4.27e-10

acyl carrier protein; Provisional


Pssm-ID: 183533 [Multi-domain]  Cd Length: 80  Bit Score: 50.47  E-value: 4.27e-10
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 503035025  3 DTLERVRKIVIDHLDADPDKVTEKASFIDDLGADSLDNVELVMAFEEEFDIEIPDDAAEHIQTVGDAVKFIDEKTA 78
Cdd:PRK12449  5 EIFERLINLIQKQRSYLSLAITEQTHLKDDLAVDSIELVEFIINVEDEFHIAIPDEDVEDMVSMGDLLDYLVQRLT 80
AcpM NF040636
meromycolate extension acyl carrier protein AcpM;
19-73 1.83e-08

meromycolate extension acyl carrier protein AcpM;


Pssm-ID: 468604  Cd Length: 93  Bit Score: 46.66  E-value: 1.83e-08
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....*
gi 503035025 19 DPDKVTEKASFIDDLGADSLDNVELVMAFEEEFDIEIPDDAAEHIQTVGDAVKFI 73
Cdd:NF040636 21 EPSEVTIEKSFVDDLDIDSLSMVEIAVQLEDKYGVKIPDEDLASLRTVGDAVAYV 75
PRK06508 PRK06508
acyl carrier protein; Provisional
 1-56 3.01e-08

acyl carrier protein; Provisional


Pssm-ID: 180597  Cd Length: 93  Bit Score: 46.35  E-value: 3.01e-08
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....*.
gi 503035025  1 MSDTLERVRKIVIDHLDADPDKVTEKASFIDDLGADSLDNVELVMAFEEEFDIEIP 56
Cdd:PRK06508  1 MSSTFDKVADIIAETSDIPRDTITPESHTIDDLGIDSLDFLDIVFAIDKAFGIKLP 56
PRK08172 PRK08172
acyl carrier protein;
3-68 1.45e-07

acyl carrier protein;


Pssm-ID: 181266  Cd Length: 82  Bit Score: 44.11  E-value: 1.45e-07
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 503035025  3 DTLERVRKIVIDHLDADPDKVTEKASFIDDLGADSLDNVELVMAFEEEFDIEIPDDAAEHIQTVGD 68
Cdd:PRK08172  4 DIEARVKKVITSCIAVDVDSINGQTHLVEDLYADSLDLIDIVFGLSEEFDISCNENDLPDMTTFAD 69
PP-binding pfam00550
Phosphopantetheine attachment site; A 4'-phosphopantetheine prosthetic group is attached ...
 6-68 4.08e-07

Phosphopantetheine attachment site; A 4'-phosphopantetheine prosthetic group is attached through a serine. This prosthetic group acts as a a 'swinging arm' for the attachment of activated fatty acid and amino-acid groups. This domain forms a four helix bundle. This family includes members not included in Prosite. The inclusion of these members is supported by sequence analysis and functional evidence. The related domain of Swiss:P19828 has the attachment serine replaced by an alanine.


Pssm-ID: 425746 [Multi-domain]  Cd Length: 62  Bit Score: 42.55  E-value: 4.08e-07
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 503035025   6 ERVRKIVIDHLDADPDKVTEKASFiDDLGADSLDNVELVMAFEEEFDIEIPDDAAEHIQTVGD 68
Cdd:pfam00550  1 ERLRELLAEVLGVPAEEIDPDTDL-FDLGLDSLLAVELIARLEEEFGVEIPPSDLFEHPTLAE 62
PRK07081 PRK07081
acyl carrier protein; Provisional
 8-57 9.12e-05

acyl carrier protein; Provisional


Pssm-ID: 180828  Cd Length: 83  Bit Score: 36.86  E-value: 9.12e-05
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|..
gi 503035025  8 VRKIVIDH--LDADPDKVTEKASFIDdLGADSLDNVELVMAFEEEFDIEIPD 57
Cdd:PRK07081  5 IRTILKKVakLEVPIDSIADDADLYE-AGLSSLATVQLMLAIEDAFDIEIPD 55
PRK05350 PRK05350
acyl carrier protein; Provisional
 3-79 2.70e-04

acyl carrier protein; Provisional


Pssm-ID: 180033  Cd Length: 82  Bit Score: 35.74  E-value: 2.70e-04
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 503035025  3 DTLERVRKIVIDHLDADPDKVTEKASFIDDLGADSLDNVELVMAFEEEFDIEIPDDAAEHIQTVGDAVKFIDEKTAA 79
Cdd:PRK05350  6 EILERLRAILVELFEIDPEDITPEANLYEDLDLDSIDAVDLVVHLQKLTGKKIKPEEFKSVRTVQDVVDAVERLLKE 82
PKS_PP smart00823
Phosphopantetheine attachment site; Phosphopantetheine (or pantetheine 4' phosphate) is the ...
 5-56 9.04e-03

Phosphopantetheine attachment site; Phosphopantetheine (or pantetheine 4' phosphate) is the prosthetic group of acyl carrier proteins (ACP) in some multienzyme complexes where it serves as a 'swinging arm' for the attachment of activated fatty acid and amino-acid groups.


Pssm-ID: 214834 [Multi-domain]  Cd Length: 86  Bit Score: 31.84  E-value: 9.04e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 503035025    5 LERVRKIVIDHLD-ADPDKVTEKASFIDdLGADSLDNVELVMAFEEEFDIEIP 56
Cdd:smart00823 14 LDLVREQVAAVLGhAAAEAIDPDRPFRD-LGLDSLMAVELRNRLEAATGLRLP 65
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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