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Conserved domains on  [gi|503124596|ref|WP_013359257|]
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MULTISPECIES: taurine ABC transporter permease TauC [Pantoea]

Protein Classification

ABC transporter permease( domain architecture ID 30)

ABC transporter permease is the transmembrane subunit (TM) found in periplasmic binding protein (PBP)-dependent ATP-binding cassette (ABC) transporters which generally bind type 2 PBPs

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
TM_PBP2 super family cl00427
Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding ...
 1-275 2.64e-144

Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and are mainly involved in importing solutes from the environment. The solute is captured by the PBP which delivers it to a gated translocation pathway formed by the two TMs. The two ABCs bind and hydrolyze ATP and drive the transport reaction. For these transporters the ABCs and TMs are on independent polypeptide chains. These systems transport a diverse range of substrates. Most are specific for a single substrate or a group of related substrates; however some transporters are more promiscuous, transporting structurally diverse substrates such as the histidine/lysine and arginine transporter in Enterobacteriaceae. In the latter case, this is achieved through binding different PBPs with different specificities to the TMs. For other promiscuous transporters such as the multiple-sugar transporter Msm of Streptococcus mutans, the PBP has a wide substrate specificity. These transporters include the maltose-maltodextrin, phosphate and sulfate transporters, among others.


The actual alignment was detected with superfamily member PRK10160:

Pssm-ID: 444901  Cd Length: 275  Bit Score: 405.71  E-value: 2.64e-144
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503124596   1 MSALIHDKSLPVRRRLRWPFSTAFTLSVLSLSLLLLLWWGVTALGLIAPLFLPSPQQVFSKLLVIASAQGFMDATLWQHL 80
Cdd:PRK10160   1 MSVLINEKLHSRRLKWRWPLSRQLTLSIGTLAVLLAVWWAVAALQLISPLFLPPPQQVLAKLLTIAGPQGFMDATLWQHL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503124596  81 AASLTRMLIALTAAAAIGIPVGILMGLSPVARGLLDPLIEIYRPIPPLAYLPLMVIWFGIGETSKILLIYLAIFAPVTLS 160
Cdd:PRK10160  81 AASLTRIVLALLAAVVIGIPVGIAMGLSPTVRGILDPLIELYRPVPPLAYLPLMVIWFGIGETSKILLIYLAIFAPVAMS 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503124596 161 TLAGVRNTQQVRIRAARSLGANRWQLLRWVILPGALPEILTGLRIGLGVGWSTLVAAELIAATRGLGFMVQSAGEFLATD 240
Cdd:PRK10160 161 ALAGVKSAQQVRIRAAQSLGASRAQVLWFVILPGALPEILTGLRIGLGVGWSTLVAAELIAATRGLGFMVQSAGEFLATD 240

                        250       260       270
                 ....*....|....*....|....*....|....*
gi 503124596 241 VVLAGIAVIAFIAFSLELGLRALQRRLTPWSGEQS 275
Cdd:PRK10160 241 VVLAGIAVIAIIAFLLELGLRALQRRLTPWHGEVQ 275
 
Name Accession Description Interval E-value
PRK10160 PRK10160
taurine ABC transporter permease TauC;
1-275 2.64e-144

taurine ABC transporter permease TauC;


Pssm-ID: 182276  Cd Length: 275  Bit Score: 405.71  E-value: 2.64e-144
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503124596   1 MSALIHDKSLPVRRRLRWPFSTAFTLSVLSLSLLLLLWWGVTALGLIAPLFLPSPQQVFSKLLVIASAQGFMDATLWQHL 80
Cdd:PRK10160   1 MSVLINEKLHSRRLKWRWPLSRQLTLSIGTLAVLLAVWWAVAALQLISPLFLPPPQQVLAKLLTIAGPQGFMDATLWQHL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503124596  81 AASLTRMLIALTAAAAIGIPVGILMGLSPVARGLLDPLIEIYRPIPPLAYLPLMVIWFGIGETSKILLIYLAIFAPVTLS 160
Cdd:PRK10160  81 AASLTRIVLALLAAVVIGIPVGIAMGLSPTVRGILDPLIELYRPVPPLAYLPLMVIWFGIGETSKILLIYLAIFAPVAMS 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503124596 161 TLAGVRNTQQVRIRAARSLGANRWQLLRWVILPGALPEILTGLRIGLGVGWSTLVAAELIAATRGLGFMVQSAGEFLATD 240
Cdd:PRK10160 161 ALAGVKSAQQVRIRAAQSLGASRAQVLWFVILPGALPEILTGLRIGLGVGWSTLVAAELIAATRGLGFMVQSAGEFLATD 240

                        250       260       270
                 ....*....|....*....|....*....|....*
gi 503124596 241 VVLAGIAVIAFIAFSLELGLRALQRRLTPWSGEQS 275
Cdd:PRK10160 241 VVLAGIAVIAIIAFLLELGLRALQRRLTPWHGEVQ 275
TauC COG0600
ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion ...
 38-270 7.07e-71

ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism];


Pssm-ID: 440365 [Multi-domain]  Cd Length: 254  Bit Score: 218.48  E-value: 7.07e-71
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503124596  38 WWGVTALGLIAPLFLPSPQQVFSKLlviasAQGFMDATLWQHLAASLTRMLIALTAAAAIGIPVGILMGLSPVARGLLDP 117
Cdd:COG0600   26 WELAARLGLVPPFLLPSPSAVLAAL-----VELLASGELWEHLLASLLRVLLGFALAALLGVPLGLLLGLSRLLRRLLDP 100

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503124596 118 LIEIYRPIPPLAYLPLMVIWFGIGETSKILLIYLAIFAPVTLSTLAGVRNTQQVRIRAARSLGANRWQLLRWVILPGALP 197
Cdd:COG0600  101 LLVFLRPIPPLALAPLLILWFGIGEASKIFVIFLGAFFPILLNTAAGVRSVDPELLELARSLGASRWQILRKVVLPAALP 180

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 503124596 198 EILTGLRIGLGVGWSTLVAAELIAATRGLGFMVQSAGEFLATDVVLAGIAVIAFIAFSLELGLRALQRRLTPW 270
Cdd:COG0600  181 YIFTGLRIALGLAWIGLVVAELLGASSGLGYLILDARQLLDTDLVFAAILVIGLLGLLLDLLLRLLERRLLRW 253
ntrB TIGR01183
nitrate ABC transporter, permease protein; This model describes the nitrate transport permease ...
 70-248 1.36e-24

nitrate ABC transporter, permease protein; This model describes the nitrate transport permease in bacteria. This is gene product of ntrB. The nitrate transport permease is the integral membrane component of the nitrate transport system and belongs to the ATP-binding cassette (ABC) superfamily. At least in photosynthetic bacteria nitrate assimilation is aided by other proteins derived from the operon which among others include products of ntrA, ntrB, ntrC, ntrD, narB. Functionally ntrC and ntrD resemble the ATP binding components of the binding protein-dependent transport systems. Mutational studies have shown that ntrB and ntrC are mandatory for nitrate accumulation. Nitrate reductase is encoded by narB. [Transport and binding proteins, Anions]


Pssm-ID: 130251  Cd Length: 202  Bit Score: 97.56  E-value: 1.36e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503124596   70 GFMDATLWQHLAASLTRMLIALTAAAAIGIPVGILMGLSPVARGLLDPLIEIYRPIPPLAYLPLMVIWFGIGETSKILLI 149
Cdd:TIGR01183   9 GGTDKGLFWQIIASLTRVAVGFSIAAIIGIAVGILIGLSKFLNAALDPIFQVLRTIPPLAWLPIALAAFQDAQPAAIFVI 88

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503124596  150 YLAIFAPVTLSTLAGVRNTQQVRIRAARSLGANRWQLLRWVILPGALPEILTGLRIGLGVGWSTLVAAELIAATRGLGFM 229
Cdd:TIGR01183  89 FITAIWPIIINTAVGVQQIPQDYNNVARVLKLSKSDYFLKVLLPAAVPYIFTGLRIAIGLSWLAIVAAEMLMGGVGIGFF 168

                         170       180
                  ....*....|....*....|
gi 503124596  230 VQSA-GEFLATDVVLAGIAV 248
Cdd:TIGR01183 169 IWDAyNSGSVSEIILAIIYV 188
BPD_transp_1 pfam00528
Binding-protein-dependent transport system inner membrane component; The alignments cover the ...
 98-269 7.66e-16

Binding-protein-dependent transport system inner membrane component; The alignments cover the most conserved region of the proteins, which is thought to be located in a cytoplasmic loop between two transmembrane domains. The members of this family have a variable number of transmembrane helices.


Pssm-ID: 334128 [Multi-domain]  Cd Length: 183  Bit Score: 73.49  E-value: 7.66e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503124596   98 GIPVGILMGLSP--VARGLLDPLIEIYRPIPPLAYLPLMVI-----WFGIGETSKILLIYLAIFAPVTLSTLAGVRNTQQ 170
Cdd:pfam00528   1 GIPLGIIAALRRgrRLDRLLRPLIDLLQALPSFVLAILLVViailsILGHGILPAIILALLGWAGYARLIRRAALRSLPS 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503124596  171 VRIRAARSLGANRWQLLRWVILPGALPEILTGLRIGLGVGWSTLVAAELIAATRGLGFMVQSAGEFLATDVVLAGIAVIA 250
Cdd:pfam00528  81 DLVEAARALGASRWQIFRKIILPNALPPILTGLALAFGGALGGAVLLEFLGSWPGLGLLLIEAILGYDYPEIQGPVLAAA 160

                         170
                  ....*....|....*....
gi 503124596  251 FIAFSLELGLRALQRRLTP 269
Cdd:pfam00528 161 LILLLLNLLVDILQRLLDP 179
TM_PBP2 cd06261
Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding ...
 98-253 7.34e-10

Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and are mainly involved in importing solutes from the environment. The solute is captured by the PBP which delivers it to a gated translocation pathway formed by the two TMs. The two ABCs bind and hydrolyze ATP and drive the transport reaction. For these transporters the ABCs and TMs are on independent polypeptide chains. These systems transport a diverse range of substrates. Most are specific for a single substrate or a group of related substrates; however some transporters are more promiscuous, transporting structurally diverse substrates such as the histidine/lysine and arginine transporter in Enterobacteriaceae. In the latter case, this is achieved through binding different PBPs with different specificities to the TMs. For other promiscuous transporters such as the multiple-sugar transporter Msm of Streptococcus mutans, the PBP has a wide substrate specificity. These transporters include the maltose-maltodextrin, phosphate and sulfate transporters, among others.


Pssm-ID: 119394 [Multi-domain]  Cd Length: 190  Bit Score: 56.90  E-value: 7.34e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503124596  98 GIPVGILMGLS-PVARGLLDPLIEIYRPIPPLAYLPLMVIWFGIGETSK---------ILLIYLAIFAPVTLSTLAGVRN 167
Cdd:cd06261   19 GLLLGIILARKrGKLDRLLRRIIDLLLSLPSLVLGLLLVLLFGVLLGWGilpglglpaLILALLLIAPFARLIRRAALES 98

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503124596 168 TQQVRIRAARSLGANRWQLLRWVILPGALPEILTGLRIGLGVGWSTLVAAELIAATR----GLGFMVQSAGEFLATDVVL 243
Cdd:cd06261   99 IPKDLVEAARALGASPWQIFRRIILPLALPPILTGLVLAFARALGEFALVSFLGGGEapgpGTGLLLIFAILFPGDLGVA 178

                        170
                 ....*....|
gi 503124596 244 AGIAVIAFIA 253
Cdd:cd06261  179 AAVALILLLL 188
 
Name Accession Description Interval E-value
PRK10160 PRK10160
taurine ABC transporter permease TauC;
1-275 2.64e-144

taurine ABC transporter permease TauC;


Pssm-ID: 182276  Cd Length: 275  Bit Score: 405.71  E-value: 2.64e-144
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503124596   1 MSALIHDKSLPVRRRLRWPFSTAFTLSVLSLSLLLLLWWGVTALGLIAPLFLPSPQQVFSKLLVIASAQGFMDATLWQHL 80
Cdd:PRK10160   1 MSVLINEKLHSRRLKWRWPLSRQLTLSIGTLAVLLAVWWAVAALQLISPLFLPPPQQVLAKLLTIAGPQGFMDATLWQHL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503124596  81 AASLTRMLIALTAAAAIGIPVGILMGLSPVARGLLDPLIEIYRPIPPLAYLPLMVIWFGIGETSKILLIYLAIFAPVTLS 160
Cdd:PRK10160  81 AASLTRIVLALLAAVVIGIPVGIAMGLSPTVRGILDPLIELYRPVPPLAYLPLMVIWFGIGETSKILLIYLAIFAPVAMS 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503124596 161 TLAGVRNTQQVRIRAARSLGANRWQLLRWVILPGALPEILTGLRIGLGVGWSTLVAAELIAATRGLGFMVQSAGEFLATD 240
Cdd:PRK10160 161 ALAGVKSAQQVRIRAAQSLGASRAQVLWFVILPGALPEILTGLRIGLGVGWSTLVAAELIAATRGLGFMVQSAGEFLATD 240

                        250       260       270
                 ....*....|....*....|....*....|....*
gi 503124596 241 VVLAGIAVIAFIAFSLELGLRALQRRLTPWSGEQS 275
Cdd:PRK10160 241 VVLAGIAVIAIIAFLLELGLRALQRRLTPWHGEVQ 275
TauC COG0600
ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion ...
 38-270 7.07e-71

ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism];


Pssm-ID: 440365 [Multi-domain]  Cd Length: 254  Bit Score: 218.48  E-value: 7.07e-71
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503124596  38 WWGVTALGLIAPLFLPSPQQVFSKLlviasAQGFMDATLWQHLAASLTRMLIALTAAAAIGIPVGILMGLSPVARGLLDP 117
Cdd:COG0600   26 WELAARLGLVPPFLLPSPSAVLAAL-----VELLASGELWEHLLASLLRVLLGFALAALLGVPLGLLLGLSRLLRRLLDP 100

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503124596 118 LIEIYRPIPPLAYLPLMVIWFGIGETSKILLIYLAIFAPVTLSTLAGVRNTQQVRIRAARSLGANRWQLLRWVILPGALP 197
Cdd:COG0600  101 LLVFLRPIPPLALAPLLILWFGIGEASKIFVIFLGAFFPILLNTAAGVRSVDPELLELARSLGASRWQILRKVVLPAALP 180

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 503124596 198 EILTGLRIGLGVGWSTLVAAELIAATRGLGFMVQSAGEFLATDVVLAGIAVIAFIAFSLELGLRALQRRLTPW 270
Cdd:COG0600  181 YIFTGLRIALGLAWIGLVVAELLGASSGLGYLILDARQLLDTDLVFAAILVIGLLGLLLDLLLRLLERRLLRW 253
ssuC PRK11365
aliphatic sulfonate ABC transporter permease SsuC;
38-270 2.46e-40

aliphatic sulfonate ABC transporter permease SsuC;


Pssm-ID: 183100  Cd Length: 263  Bit Score: 140.46  E-value: 2.46e-40
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503124596  38 WWGVTALGLIAPLFLPSPQQVFSKLLVIASAqgfmdATLWQHLAASLTRMLIALTAAAAIGIPVGILMGLSPVARGLLDP 117
Cdd:PRK11365  25 WQLASSVGWLSTRILPSPEGVVTAFWTLSAS-----GELWQHLAISSWRALIGFSIGGSLGLILGLISGLSRWGERLLDT 99

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503124596 118 LIEIYRPIPPLAYLPLMVIWFGIGETSKILLIYLAIFAPVTLSTLAGVRNTQQVRIRAARSLGANRWQLLRWVILPGALP 197
Cdd:PRK11365 100 SIQMLRNVPHLALIPLVILWFGIDESAKIFLVALGTLFPIYINTWHGIRNIDRGLVEMARSYGLSGIPLFIHVILPGALP 179

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 503124596 198 EILTGLRIGLGVGWSTLVAAELIAATRGLGFMVQSAGEFLATDVVLAGIAVIAFIAFSLELGLRALQRRLTPW 270
Cdd:PRK11365 180 SIMVGVRFALGLMWLTLIVAETISANSGIGYLAMNAREFLQTDVVVVAIILYALLGKLADVSAQLLERLWLRW 252
ntrB TIGR01183
nitrate ABC transporter, permease protein; This model describes the nitrate transport permease ...
 70-248 1.36e-24

nitrate ABC transporter, permease protein; This model describes the nitrate transport permease in bacteria. This is gene product of ntrB. The nitrate transport permease is the integral membrane component of the nitrate transport system and belongs to the ATP-binding cassette (ABC) superfamily. At least in photosynthetic bacteria nitrate assimilation is aided by other proteins derived from the operon which among others include products of ntrA, ntrB, ntrC, ntrD, narB. Functionally ntrC and ntrD resemble the ATP binding components of the binding protein-dependent transport systems. Mutational studies have shown that ntrB and ntrC are mandatory for nitrate accumulation. Nitrate reductase is encoded by narB. [Transport and binding proteins, Anions]


Pssm-ID: 130251  Cd Length: 202  Bit Score: 97.56  E-value: 1.36e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503124596   70 GFMDATLWQHLAASLTRMLIALTAAAAIGIPVGILMGLSPVARGLLDPLIEIYRPIPPLAYLPLMVIWFGIGETSKILLI 149
Cdd:TIGR01183   9 GGTDKGLFWQIIASLTRVAVGFSIAAIIGIAVGILIGLSKFLNAALDPIFQVLRTIPPLAWLPIALAAFQDAQPAAIFVI 88

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503124596  150 YLAIFAPVTLSTLAGVRNTQQVRIRAARSLGANRWQLLRWVILPGALPEILTGLRIGLGVGWSTLVAAELIAATRGLGFM 229
Cdd:TIGR01183  89 FITAIWPIIINTAVGVQQIPQDYNNVARVLKLSKSDYFLKVLLPAAVPYIFTGLRIAIGLSWLAIVAAEMLMGGVGIGFF 168

                         170       180
                  ....*....|....*....|
gi 503124596  230 VQSA-GEFLATDVVLAGIAV 248
Cdd:TIGR01183 169 IWDAyNSGSVSEIILAIIYV 188
OpuBB COG1174
ABC-type proline/glycine betaine transport system, permease component [Amino acid transport ...
 65-270 1.20e-20

ABC-type proline/glycine betaine transport system, permease component [Amino acid transport and metabolism];


Pssm-ID: 440787 [Multi-domain]  Cd Length: 212  Bit Score: 87.03  E-value: 1.20e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503124596  65 IASAQGFMDATLWQHLAASLTRMLIALTAaaaiGIPVGILMGLSPVARGLLDPLIEIYRPIPPLAYLPLMVIWFGIGETS 144
Cdd:COG1174    9 LADNRDGILALLLEHLLLVLLALLIALLI----AVPLGILITRRRRLAGLVLGVANILQTIPSLALLALLIPLLGIGPAP 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503124596 145 KILLIYLAIFAPVTLSTLAGVRNTQQVRIRAARSLGANRWQLLRWVILPGALPEILTGLRIGL--GVGWSTLVAaeLIAA 222
Cdd:COG1174   85 AIIALVLYALLPILRNTYTGLRSVDPAVVEAARGMGMTPWQRLWRVELPLALPVILAGIRTAAvqNIGTATLAA--LIGA 162

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*...
gi 503124596 223 tRGLGFMVQSAGEFLATDVVLAGIAVIAFIAFSLELGLRALQRRLTPW 270
Cdd:COG1174  163 -GGLGDLIFDGLQLNNTALILAGAILVALLALLVDLLLALLERLLTPR 209
BPD_transp_1 pfam00528
Binding-protein-dependent transport system inner membrane component; The alignments cover the ...
 98-269 7.66e-16

Binding-protein-dependent transport system inner membrane component; The alignments cover the most conserved region of the proteins, which is thought to be located in a cytoplasmic loop between two transmembrane domains. The members of this family have a variable number of transmembrane helices.


Pssm-ID: 334128 [Multi-domain]  Cd Length: 183  Bit Score: 73.49  E-value: 7.66e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503124596   98 GIPVGILMGLSP--VARGLLDPLIEIYRPIPPLAYLPLMVI-----WFGIGETSKILLIYLAIFAPVTLSTLAGVRNTQQ 170
Cdd:pfam00528   1 GIPLGIIAALRRgrRLDRLLRPLIDLLQALPSFVLAILLVViailsILGHGILPAIILALLGWAGYARLIRRAALRSLPS 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503124596  171 VRIRAARSLGANRWQLLRWVILPGALPEILTGLRIGLGVGWSTLVAAELIAATRGLGFMVQSAGEFLATDVVLAGIAVIA 250
Cdd:pfam00528  81 DLVEAARALGASRWQIFRKIILPNALPPILTGLALAFGGALGGAVLLEFLGSWPGLGLLLIEAILGYDYPEIQGPVLAAA 160

                         170
                  ....*....|....*....
gi 503124596  251 FIAFSLELGLRALQRRLTP 269
Cdd:pfam00528 161 LILLLLNLLVDILQRLLDP 179
PRK10952 PRK10952
proline/glycine betaine ABC transporter permease ProW;
98-230 9.51e-11

proline/glycine betaine ABC transporter permease ProW;


Pssm-ID: 236805  Cd Length: 355  Bit Score: 61.26  E-value: 9.51e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503124596  98 GIPVGILMGLSPVARGLLDPLIEIYRPIPPLAYLPLMVIWFGIGETSKILLIYLAIFAPVTLSTLAGVRNTQQVRIRAAR 177
Cdd:PRK10952 164 GLPLGIWLARSPRAAKIIRPLLDAMQTTPAFVYLVPIVMLFGIGNVPGVVVTIIFALPPIVRLTILGINQVPADLIEASR 243

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|...
gi 503124596 178 SLGANRWQLLRWVILPGALPEILTGLRIGLGVGWSTLVAAELIAATrGLGFMV 230
Cdd:PRK10952 244 SFGASPRQMLFKVQLPLAMPTIMAGVNQTLMLALSMVVIASMIAVG-GLGQMV 295
TM_PBP2 cd06261
Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding ...
 98-253 7.34e-10

Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and are mainly involved in importing solutes from the environment. The solute is captured by the PBP which delivers it to a gated translocation pathway formed by the two TMs. The two ABCs bind and hydrolyze ATP and drive the transport reaction. For these transporters the ABCs and TMs are on independent polypeptide chains. These systems transport a diverse range of substrates. Most are specific for a single substrate or a group of related substrates; however some transporters are more promiscuous, transporting structurally diverse substrates such as the histidine/lysine and arginine transporter in Enterobacteriaceae. In the latter case, this is achieved through binding different PBPs with different specificities to the TMs. For other promiscuous transporters such as the multiple-sugar transporter Msm of Streptococcus mutans, the PBP has a wide substrate specificity. These transporters include the maltose-maltodextrin, phosphate and sulfate transporters, among others.


Pssm-ID: 119394 [Multi-domain]  Cd Length: 190  Bit Score: 56.90  E-value: 7.34e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503124596  98 GIPVGILMGLS-PVARGLLDPLIEIYRPIPPLAYLPLMVIWFGIGETSK---------ILLIYLAIFAPVTLSTLAGVRN 167
Cdd:cd06261   19 GLLLGIILARKrGKLDRLLRRIIDLLLSLPSLVLGLLLVLLFGVLLGWGilpglglpaLILALLLIAPFARLIRRAALES 98

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503124596 168 TQQVRIRAARSLGANRWQLLRWVILPGALPEILTGLRIGLGVGWSTLVAAELIAATR----GLGFMVQSAGEFLATDVVL 243
Cdd:cd06261   99 IPKDLVEAARALGASPWQIFRRIILPLALPPILTGLVLAFARALGEFALVSFLGGGEapgpGTGLLLIFAILFPGDLGVA 178

                        170
                 ....*....|
gi 503124596 244 AGIAVIAFIA 253
Cdd:cd06261  179 AAVALILLLL 188
COG4986 COG4986
ABC-type anion transport system, duplicated permease component [Inorganic ion transport and ...
 99-251 1.79e-04

ABC-type anion transport system, duplicated permease component [Inorganic ion transport and metabolism];


Pssm-ID: 444010 [Multi-domain]  Cd Length: 576  Bit Score: 42.52  E-value: 1.79e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503124596  99 IPVGILMGLSPVARGLLDPLIEIYRPIPPLAYLPLMVIWF-GIGETSKILLIYLAIFAP---VTLSTLAGVRNTQQVRIR 174
Cdd:COG4986  390 VPVGVWIGLRPRLARRLQPVAQFLASFPANLLFPVAVLLIvRFGLNPNIWLSPLMILGTqwyILFNVIAGASAIPNDLRE 469

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503124596 175 AARSLGANRWQLLRWVILPGALPEILTGLRIGLGVGWSTLVAAELIA------ATRGLGFMVQSAGEFLATDVVLAGIAV 248
Cdd:COG4986  470 AARNFGLRGWLWWRRLILPGIFPYYVTGAITASGGAWNASIVAEYVSwgdttlQATGLGAYIAQATAAGDFPRILLGIAV 549


                 ...
gi 503124596 249 IAF 251
Cdd:COG4986  550 MSL 552
PRK09881 PRK09881
D,D-dipeptide ABC transporter permease;
169-229 2.30e-04

D,D-dipeptide ABC transporter permease;


Pssm-ID: 182131 [Multi-domain]  Cd Length: 296  Bit Score: 41.73  E-value: 2.30e-04
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 503124596 169 QQVRIRAARSLGANRWQLLRWVILPGALPEILTGLRIGLGvgwstlvAAELIAATrgLGFM 229
Cdd:PRK09881 184 QYTYVQAAKTFGASRWHLISWHILRNSLPPLIVQASLDIG-------SAILMAAT--LGFI 235
PhnE TIGR01097
phosphonate ABC transporter, permease protein PhnE; Phosphonates are a class of compound ...
 98-267 3.32e-04

phosphonate ABC transporter, permease protein PhnE; Phosphonates are a class of compound analogous to organic phosphates, but in which the C-O-P linkage is replaced by a direct, stable C-P bond. Some bacteria can utilize phosphonates as a source of phosphorus. This family consists of permease proteins of known or predicted phosphonate ABC transporters. Often this protein is found as a duplicated pair, occasionally as a fused pair. Certain "second" copies score in between the trusted and noise cutoff and should be considered true hits (by context). [Transport and binding proteins, Anions]


Pssm-ID: 273441 [Multi-domain]  Cd Length: 250  Bit Score: 40.99  E-value: 3.32e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503124596   98 GIPVGIL----MGLSPVARGLLDPLIEIYRPIPPLAYLPLMVIWFGIGETSKILLIYLAIFAPVTLSTLAGVRNTQQVRI 173
Cdd:TIGR01097  78 AVPLALLaarnITPSPWLYGLARLLLNFLRAIPELVWALIFVAAVGLGPFAGVLALAFHTVGFLGKLFAEAIEEVDPGPV 157

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503124596  174 RAARSLGANRWQLLRWVILPGALPEIL--TGLRIGLGVGWSTLVAaeLIAATrGLGFMVQSAGEFLATDVVLAGIAVIAF 251
Cdd:TIGR01097 158 EALRATGASKLQVIRYGVLPQVLPQFLsyTLYRFEINVRAAAVLG--LVGAG-GIGLELDTAIGLFDYDEVSAIILVILV 234

                         170
                  ....*....|....*.
gi 503124596  252 IAFSLELGLRALQRRL 267
Cdd:TIGR01097 235 VVVIIDLISARLRRRL 250
HisM COG0765
ABC-type amino acid transport system, permease component [Amino acid transport and metabolism]; ...
 98-267 3.60e-04

ABC-type amino acid transport system, permease component [Amino acid transport and metabolism];


Pssm-ID: 440528 [Multi-domain]  Cd Length: 218  Bit Score: 40.83  E-value: 3.60e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503124596  98 GIPVGILMGL-----SPVARGLLDPLIEIYRPIPPLayLPLMVIWFGIGEtskiLLIYLAIF--APVTLSTLAGVRNTQQ 170
Cdd:COG0765   33 GLVLGLLLALarlspNPVLRWLATAYVEFFRGTPLL--VQLFFIYFGLPL----LGIDLSPFvaAVIALTLNSAAYLAEI 106

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503124596 171 VR----------IRAARSLGANRWQLLRWVILPGALPEI---LTGLRIGLgVGWSTLVAAelIAATRGLGFMVQSAGEFL 237
Cdd:COG0765  107 VRagiqsvpkgqWEAARALGLSRWQTMRRIILPQALRIIlppLGNEFISL-LKDTSLVSV--IGVPELTRAAQQIASRTF 183

                        170       180       190
                 ....*....|....*....|....*....|.
gi 503124596 238 ATDVVLAGIAVIAF-IAFSLELGLRALQRRL 267
Cdd:COG0765  184 RPFEVYLVAALIYLvLTLPLSLLARRLERRL 214
CysU COG0555
ABC-type sulfate transport system, permease component [Inorganic ion transport and metabolism]; ...
 175-203 9.58e-04

ABC-type sulfate transport system, permease component [Inorganic ion transport and metabolism];


Pssm-ID: 440321 [Multi-domain]  Cd Length: 268  Bit Score: 39.73  E-value: 9.58e-04
                         10        20
                 ....*....|....*....|....*....
gi 503124596 175 AARSLGANRWQLLRWVILPGALPEILTGL 203
Cdd:COG0555  169 AAATLGASRWQTFRRVILPLLLPALLTGF 197
PstA COG0581
ABC-type phosphate transport system, permease component [Inorganic ion transport and ...
 175-208 1.67e-03

ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism];


Pssm-ID: 440346 [Multi-domain]  Cd Length: 259  Bit Score: 38.86  E-value: 1.67e-03
                         10        20        30
                 ....*....|....*....|....*....|....
gi 503124596 175 AARSLGANRWQLLRWVILPGALPEILTGLRIGLG 208
Cdd:COG0581  147 ASYALGATKWQTIRKVVLPAALPGILTGVILAIA 180
PotC COG1177
ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport ...
 146-202 1.90e-03

ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism];


Pssm-ID: 440790 [Multi-domain]  Cd Length: 262  Bit Score: 38.94  E-value: 1.90e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 503124596 146 ILLIYLAIFAP-VTLSTLAGVRNTQQVRIRAARSLGANRWQLLRWVILPGALPEILTG 202
Cdd:COG1177  134 LILAHVVFTLPfVVLVVLARLQGFDPSLEEAARDLGASPWQTFRRVTLPLIAPGILAG 191
PRK15050 PRK15050
2-aminoethylphosphonate transport system permease PhnU; Provisional
 146-202 2.49e-03

2-aminoethylphosphonate transport system permease PhnU; Provisional


Pssm-ID: 237888 [Multi-domain]  Cd Length: 296  Bit Score: 38.83  E-value: 2.49e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 503124596 146 ILLIYLAIFAP-VTLSTLAGVRNTQQVRIRAARSLGANRWQLLRWVILPGALPEILTG 202
Cdd:PRK15050 164 VILAEITFYTPfVVRPLLAAFAQLDARQLEAAASLGASPWRVARRVILPEAWPALAAG 221
MetP COG2011
ABC-type methionine transport system, permease component [Amino acid transport and metabolism]; ...
 98-203 2.70e-03

ABC-type methionine transport system, permease component [Amino acid transport and metabolism];


Pssm-ID: 441614  Cd Length: 220  Bit Score: 38.11  E-value: 2.70e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503124596  98 GIPVGILMGLS--------PVARGLLDPLIEIYRPIPplaYLPLMVIWF---------GIGETSKIL-LIYLAI--FAPV 157
Cdd:COG2011   34 GLPLGVLLVLTrpggllpnPVLYRVLGVIVNIFRSIP---FIILLVALIpltrlivgtSIGTTAAIVpLTIAAIpfFARL 110

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*.
gi 503124596 158 TLSTLAGVrntQQVRIRAARSLGANRWQLLRWVILPGALPEILTGL 203
Cdd:COG2011  111 VENALREV---DPGVIEAAQAMGASPWQIIFKVLLPEALPSLILGL 153
PhnE COG3639
ABC-type phosphate/phosphonate transport system, permease component [Inorganic ion transport ...
 107-268 7.13e-03

ABC-type phosphate/phosphonate transport system, permease component [Inorganic ion transport and metabolism];


Pssm-ID: 442856 [Multi-domain]  Cd Length: 244  Bit Score: 36.98  E-value: 7.13e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503124596 107 LSPVARGLLDplieIYRPIPPLAYLPLMVIWFGIGETSKILLIYLAifapvTLSTLA-----GVRNTQQVRIRAARSLGA 181
Cdd:COG3639   88 VRLLARRLLN----VLRAIPELVWALIFVAAVGLGPFAGVLALAIH-----TIGFLGklfaeAIEEIDPGPVEALRATGA 158

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503124596 182 NRWQLLRWVILPGALPEIL--TGLRIGLGVGWSTLVAaeLIAATrGLGFMVQSAGEFLATDVVLAGIAVIAFIAFSLELG 259
Cdd:COG3639  159 SRLQVIRYGVLPQVLPQFLsyTLYRFEINIRAATVLG--LVGAG-GIGLLLNEAIRLFQYDEVAAILLVILVLVLLIDLL 235


                 ....*....
gi 503124596 260 LRALQRRLT 268
Cdd:COG3639  236 SARLRRRLI 244
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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