|
Name |
Accession |
Description |
Interval |
E-value |
| PBP2_lipoprotein_MetQ_like |
cd13526 |
The periplasmic-binding component of ABC-type methionine uptake transporter system and its ... |
45-272 |
3.04e-100 |
|
The periplasmic-binding component of ABC-type methionine uptake transporter system and its related lipoproteins; the type 2 periplasmic-binding protein fold; This family represents the periplasmic substrate-binding domain of ATP-binding cassette (ABC) transporter involved in uptake of methionine (MetQ) and its related homologs. Members of the MetQ-like family include the 32-kilodalton lipoprotein (Tp32) from Treponema pallidum, the membrane-associated lipoprotein-9 GmpC from Staphylococcus aureus, and Toll-like receptor 2-activating lipoprotein IlpA from Vibrio vulnificus. They all function as a receptor for methionine. This substrate-binding domain belongs to the type 2 periplasmic binding fold protein superfamily (PBP2). The PBP2 proteins are typically comprised of two globular subdomains connected by a flexible hinge and bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap. The majority of PBP2 proteins function in the uptake of small soluble substrates in eubacteria and archaea.
Pssm-ID: 270244 Cd Length: 228 Bit Score: 292.68 E-value: 3.04e-100
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503125653 45 IIKIGTT-GFFKDIVQEAKKDFESTsGYELEVIVFDDNVTPNIALDEGSIDVNFYQHVPFLDAFNKERGTNLVKYGEKGI 123
Cdd:cd13526 1 KLKIGVTaGPSADVVEAAKKEAKKK-GYELELVVFTDYVAPNEALNDGSIDANFFQHVPFLDQFNKERNGDLVKVGKTVI 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503125653 124 aCTYGIYSSKLKSLEEIPNGAKIGIANDSSNRTRGLRFLESNGFIKIKDGVDL-PTKLDVIENPKNLDLIEIDGPKLISS 202
Cdd:cd13526 80 -APIGLYSKKYKSLDELPDGARIAIPNDPSNGARALLLLEDAGLIKLKDGVGLfATVLDITENPKNLEIVEVDAAQLPRS 158
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 503125653 203 MEDVDAVVGYGIYMLLSGKDP-KSAIIFDNEEDtKRYADVIVLREDNKNVEWVKHLEAALTNEKMRKYMDE 272
Cdd:cd13526 159 LDDVDAAVINGNYAISAGLDPrKDAIFLEDSDA-SPYVNVLAVREDNKDDPWVKALVEAYQSEEVRKFLKE 228
|
|
| NlpA |
COG1464 |
ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion ... |
4-282 |
2.31e-98 |
|
ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism];
Pssm-ID: 441073 [Multi-domain] Cd Length: 270 Bit Score: 289.32 E-value: 2.31e-98
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503125653 4 KKIISLFSIIMLSIAMVGCSINANSSDDTssevdtkveEKEIIKIGTT-GFFKDIVQEAKKDFESTsGYELEVIVFDDNV 82
Cdd:COG1464 2 KKLLALLLALALALALAACGSSSAAAAAA---------DKKTIKVGATpGPHAEILEVVKPELAKK-GIDLEIVEFTDYV 71
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503125653 83 TPNIALDEGSIDVNFYQHVPFLDAFNKERGTNLVKYGEKGIAcTYGIYSSKLKSLEEIPNGAKIGIANDSSNRTRGLRFL 162
Cdd:COG1464 72 QPNEALADGEIDANYFQHIPYLDNFNKENGYDLVPVGKTHIE-PMGLYSKKYKSLDELPDGATIAIPNDPTNQGRALLLL 150
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503125653 163 ESNGFIKIKDGVDL-PTKLDVIENPKNLDLIEIDGPKLISSMEDVDAVVGYGIYMLLSGKDP-KSAIIFDNEEDTkrYAD 240
Cdd:COG1464 151 QKAGLIKLKDGVGLlATVKDITENPKNLKFVELDAAQLPRSLDDVDAAVINGNYALEAGLDPtKDALFLEDKDSP--YAN 228
|
250 260 270 280
....*....|....*....|....*....|....*....|..
gi 503125653 241 VIVLREDNKNVEWVKHLEAALTNEKMRKYMDEELEGAYIPAY 282
Cdd:COG1464 229 IIVVREDDKDDPAIKKLVEAYQSDEVKKFIEEKYKGAVVPAW 270
|
|
| Lipoprotein_9 |
pfam03180 |
NlpA lipoprotein; This entry represents bacterial lipoproteins that belong to the NlpA family. ... |
46-281 |
2.95e-69 |
|
NlpA lipoprotein; This entry represents bacterial lipoproteins that belong to the NlpA family. It contains several antigenic members, that may be involved in bacterial virulence. This entry includes the D-methionine binding lipoprotein MetQ, which is the substrate-binding component of a D-methionine permease, a binding protein-dependent, ATP-driven transport system. Other members of this family, such as NlpA, have been identified as putative substrate-binding components of ABC transporters. NlpA, is an inner-membrane-anchored lipoprotein that has been shown to have a minor role in methionine import.
Pssm-ID: 427184 Cd Length: 236 Bit Score: 214.05 E-value: 2.95e-69
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503125653 46 IKIGTT-GFFKDIVQEAKKDFEStSGYELEVIVFDDNVTPNIALDEGSIDVNFYQHVPFLDAFNKERGTNLVKYGeKGIA 124
Cdd:pfam03180 1 LKVGATpGPHAEILEVAKPLLKK-KGLDLEIVEFTDYVQPNTALADGEIDANYFQHLPYLDQFNKEKGLDLVAVG-NVHI 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503125653 125 CTYGIYSSKLKSLEEIPNGAKIGIANDSSNRTRGLRFLESNGFIKIKDGVD-LPTKLDVIENPKNLDLIEIDGPKLISSM 203
Cdd:pfam03180 79 EPMGLYSKKYKSLSELPDGATIAVPNDPSNEGRALLLLQKAGLIKLKDGKGlLATVKDITENPKNLKIKELEAAQLPRAL 158
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 503125653 204 EDVDAVVGYGIYMLLSGKDPKSAIIFdNEEDTKRYADVIVLREDNKNVEWVKHLEAALTNEKMRKYMDEELEGAYIPA 281
Cdd:pfam03180 159 DDVDAAVINTNYALEAGLNPKKDALF-EEDKDSPYVNIIVVREDDKDDEAVKKLVEAYQSEEVKKFIEKKYGGAVIPA 235
|
|
| metQ |
PRK11063 |
D-methionine ABC transporter substrate-binding protein MetQ; |
3-255 |
1.03e-46 |
|
D-methionine ABC transporter substrate-binding protein MetQ;
Pssm-ID: 182939 [Multi-domain] Cd Length: 271 Bit Score: 157.62 E-value: 1.03e-46
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503125653 3 SKKIISLFSIIML--SIAMVGCsinanssddtssevDTKVEEKEIIKIGT-TGFFKDIVQEAKKDFESTSGYELEVIVFD 79
Cdd:PRK11063 2 AFKFKTFAAVGALigTLALVGC--------------GQDEKDPNHIKVGViVGAEQQVAEVAQKVAKEKYGLDVELVTFN 67
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503125653 80 DNVTPNIALDEGSIDVNFYQHVPFLDAFNKERGTNLVKYGEKGIACTYGiYSSKLKSLEEIPNGAKIGIANDSSNRTRGL 159
Cdd:PRK11063 68 DYVLPNEALSKGDIDANAFQHKPYLDQQIKDRGYKLVAVGNTFVYPIAG-YSKKIKSLDELQDGSQVAVPNDPTNLGRSL 146
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503125653 160 RFLESNGFIKIKDGVDL-PTKLDVIENPKNLDLIEIDGPKLISSMED--VDAVVGYGIYMLLSGKDPKSAIIFDNEEDTK 236
Cdd:PRK11063 147 LLLQKVGLIKLKDGVGLlPTVLDIVENPKNLKIVELEAPQLPRSLDDaqIALAVINTTYASQIGLTPAKDGIFVEDKDSP 226
|
250
....*....|....*....
gi 503125653 237 rYADVIVLREDNKNVEWVK 255
Cdd:PRK11063 227 -YVNLIVAREDNKDAENVK 244
|
|
| TIGR00363 |
TIGR00363 |
lipoprotein, YaeC family; This family of putative lipoproteins contains a consensus site for ... |
46-282 |
1.09e-44 |
|
lipoprotein, YaeC family; This family of putative lipoproteins contains a consensus site for lipoprotein signal sequence cleavage. Included in this family is the E. coli hypothetical protein yaeC. About half of the proteins between the noise and trusted cutoffs contain the consensus lipoprotein signature and may belong to this family. [Cell envelope, Other]
Pssm-ID: 129460 Cd Length: 258 Bit Score: 151.98 E-value: 1.09e-44
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503125653 46 IKIGT-TGFFKDIVQEAKKDFESTSGYELEVIVFDDNVTPNIALDEGSIDVNFYQHVPFLDAFNKERGTNLVKYGEKGIA 124
Cdd:TIGR00363 20 IKVGViSGAEQQVAEVAAKVAKEKYGLDVELVEFNDYALPNEAVSKGDLDANAFQHKPYLDQDAKAKGYKLVAVGNTFVY 99
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503125653 125 CTYGiYSSKLKSLEEIPNGAKIGIANDSSNRTRGLRFLESNGFIKIKDGVD-LPTKLDVIENPKNLDLIEIDGPKLISSM 203
Cdd:TIGR00363 100 PLAG-YSKKIKNVNELQDGAKVAVPNDPTNLGRALLLLQKQGLIKLKDGNGlLPTVLDIVENPKKLNITELETSQLPRAL 178
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503125653 204 ED--VDAVVGYGIYMLLSGKDPKSAIIFDNEEDTKrYADVIVLREDNKNVEWVKHLEAALTNEKMRKYMDEELEGAYIPA 281
Cdd:TIGR00363 179 DDpkVDLAVINTTYAGQVGLNPQDDGVFVEDKDSP-YVNIIVSREDNKDAENVKDFIQSYQSEEVYQAAQKHFNGGAVKG 257
|
.
gi 503125653 282 Y 282
Cdd:TIGR00363 258 W 258
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| PBP2_lipoprotein_MetQ_like |
cd13526 |
The periplasmic-binding component of ABC-type methionine uptake transporter system and its ... |
45-272 |
3.04e-100 |
|
The periplasmic-binding component of ABC-type methionine uptake transporter system and its related lipoproteins; the type 2 periplasmic-binding protein fold; This family represents the periplasmic substrate-binding domain of ATP-binding cassette (ABC) transporter involved in uptake of methionine (MetQ) and its related homologs. Members of the MetQ-like family include the 32-kilodalton lipoprotein (Tp32) from Treponema pallidum, the membrane-associated lipoprotein-9 GmpC from Staphylococcus aureus, and Toll-like receptor 2-activating lipoprotein IlpA from Vibrio vulnificus. They all function as a receptor for methionine. This substrate-binding domain belongs to the type 2 periplasmic binding fold protein superfamily (PBP2). The PBP2 proteins are typically comprised of two globular subdomains connected by a flexible hinge and bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap. The majority of PBP2 proteins function in the uptake of small soluble substrates in eubacteria and archaea.
Pssm-ID: 270244 Cd Length: 228 Bit Score: 292.68 E-value: 3.04e-100
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503125653 45 IIKIGTT-GFFKDIVQEAKKDFESTsGYELEVIVFDDNVTPNIALDEGSIDVNFYQHVPFLDAFNKERGTNLVKYGEKGI 123
Cdd:cd13526 1 KLKIGVTaGPSADVVEAAKKEAKKK-GYELELVVFTDYVAPNEALNDGSIDANFFQHVPFLDQFNKERNGDLVKVGKTVI 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503125653 124 aCTYGIYSSKLKSLEEIPNGAKIGIANDSSNRTRGLRFLESNGFIKIKDGVDL-PTKLDVIENPKNLDLIEIDGPKLISS 202
Cdd:cd13526 80 -APIGLYSKKYKSLDELPDGARIAIPNDPSNGARALLLLEDAGLIKLKDGVGLfATVLDITENPKNLEIVEVDAAQLPRS 158
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 503125653 203 MEDVDAVVGYGIYMLLSGKDP-KSAIIFDNEEDtKRYADVIVLREDNKNVEWVKHLEAALTNEKMRKYMDE 272
Cdd:cd13526 159 LDDVDAAVINGNYAISAGLDPrKDAIFLEDSDA-SPYVNVLAVREDNKDDPWVKALVEAYQSEEVRKFLKE 228
|
|
| NlpA |
COG1464 |
ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion ... |
4-282 |
2.31e-98 |
|
ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism];
Pssm-ID: 441073 [Multi-domain] Cd Length: 270 Bit Score: 289.32 E-value: 2.31e-98
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503125653 4 KKIISLFSIIMLSIAMVGCSINANSSDDTssevdtkveEKEIIKIGTT-GFFKDIVQEAKKDFESTsGYELEVIVFDDNV 82
Cdd:COG1464 2 KKLLALLLALALALALAACGSSSAAAAAA---------DKKTIKVGATpGPHAEILEVVKPELAKK-GIDLEIVEFTDYV 71
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503125653 83 TPNIALDEGSIDVNFYQHVPFLDAFNKERGTNLVKYGEKGIAcTYGIYSSKLKSLEEIPNGAKIGIANDSSNRTRGLRFL 162
Cdd:COG1464 72 QPNEALADGEIDANYFQHIPYLDNFNKENGYDLVPVGKTHIE-PMGLYSKKYKSLDELPDGATIAIPNDPTNQGRALLLL 150
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503125653 163 ESNGFIKIKDGVDL-PTKLDVIENPKNLDLIEIDGPKLISSMEDVDAVVGYGIYMLLSGKDP-KSAIIFDNEEDTkrYAD 240
Cdd:COG1464 151 QKAGLIKLKDGVGLlATVKDITENPKNLKFVELDAAQLPRSLDDVDAAVINGNYALEAGLDPtKDALFLEDKDSP--YAN 228
|
250 260 270 280
....*....|....*....|....*....|....*....|..
gi 503125653 241 VIVLREDNKNVEWVKHLEAALTNEKMRKYMDEELEGAYIPAY 282
Cdd:COG1464 229 IIVVREDDKDDPAIKKLVEAYQSDEVKKFIEEKYKGAVVPAW 270
|
|
| Lipoprotein_9 |
pfam03180 |
NlpA lipoprotein; This entry represents bacterial lipoproteins that belong to the NlpA family. ... |
46-281 |
2.95e-69 |
|
NlpA lipoprotein; This entry represents bacterial lipoproteins that belong to the NlpA family. It contains several antigenic members, that may be involved in bacterial virulence. This entry includes the D-methionine binding lipoprotein MetQ, which is the substrate-binding component of a D-methionine permease, a binding protein-dependent, ATP-driven transport system. Other members of this family, such as NlpA, have been identified as putative substrate-binding components of ABC transporters. NlpA, is an inner-membrane-anchored lipoprotein that has been shown to have a minor role in methionine import.
Pssm-ID: 427184 Cd Length: 236 Bit Score: 214.05 E-value: 2.95e-69
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503125653 46 IKIGTT-GFFKDIVQEAKKDFEStSGYELEVIVFDDNVTPNIALDEGSIDVNFYQHVPFLDAFNKERGTNLVKYGeKGIA 124
Cdd:pfam03180 1 LKVGATpGPHAEILEVAKPLLKK-KGLDLEIVEFTDYVQPNTALADGEIDANYFQHLPYLDQFNKEKGLDLVAVG-NVHI 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503125653 125 CTYGIYSSKLKSLEEIPNGAKIGIANDSSNRTRGLRFLESNGFIKIKDGVD-LPTKLDVIENPKNLDLIEIDGPKLISSM 203
Cdd:pfam03180 79 EPMGLYSKKYKSLSELPDGATIAVPNDPSNEGRALLLLQKAGLIKLKDGKGlLATVKDITENPKNLKIKELEAAQLPRAL 158
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 503125653 204 EDVDAVVGYGIYMLLSGKDPKSAIIFdNEEDTKRYADVIVLREDNKNVEWVKHLEAALTNEKMRKYMDEELEGAYIPA 281
Cdd:pfam03180 159 DDVDAAVINTNYALEAGLNPKKDALF-EEDKDSPYVNIIVVREDDKDDEAVKKLVEAYQSEEVKKFIEKKYGGAVIPA 235
|
|
| PBP2_lipoprotein_Tp32 |
cd13597 |
The substrate-binding domain of the 32-kilodalton lipoprotein (Tp32) from Treponema pallidum ... |
56-280 |
3.41e-69 |
|
The substrate-binding domain of the 32-kilodalton lipoprotein (Tp32) from Treponema pallidum binds L-methionine; the type 2 periplasmic-binding protein fold; This group includes the lipoprotein Tp32, a periplasmic component of a methionine uptake transporter system, and its closely related homologs. The Tp32 has both structural and sequential homology to the MetQ family of substrate-binding protein, and thus it belongs to the type 2 periplasmic binding fold protein superfamily (PBP2). The PBP2 proteins are typically comprised of two globular subdomains connected by a flexible hinge and bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap. The majority of PBP2 proteins function in the uptake of small soluble substrates in eubacteria and archaea.
Pssm-ID: 270315 Cd Length: 236 Bit Score: 214.06 E-value: 3.41e-69
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503125653 56 DIVQEAKKDFEStSGYELEVIVFDDNVTPNIALDEGSIDVNFYQHVPFLDAFNKERGTNLVKYGEKGIAcTYGIYSSKLK 135
Cdd:cd13597 13 EILEFIKPELKK-QGIDLEIVEFTDYVQPNTALADGELDANYFQHVPYLESFNKEKGYDLVAVAGVHLE-PMGLYSKKYK 90
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503125653 136 SLEEIPNGAKIGIANDSSNRTRGLRFLESNGFIKIKDGVDLP-TKLDVIENPKNLDLIEIDGPKLISSMEDVDAVVGYGI 214
Cdd:cd13597 91 SLEDLPDGATIAIPNDPTNQGRALLLLEEAGLITLKDGAGLTaTVKDIVKNPKNLKFKELEAAQLPRSLDDVDAAVINGN 170
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 503125653 215 YMLLSGKDPKSAIIFDNEEDTKRYADVIVLREDNKNVEWVKHLEAALTNEKMRKYMDEELEGAYIP 280
Cdd:cd13597 171 YALEAGLNPKKDALALEDKDNSPYANILVVRKGNEDDPRIKKLAKALQSDEVKDFIEEKYDGAVVP 236
|
|
| PBP2_lipoprotein_IlpA_like |
cd13598 |
Toll-like receptor 2-activating lipoprotein IlpA from Vibrio vulnificus and similar ... |
45-272 |
7.10e-60 |
|
Toll-like receptor 2-activating lipoprotein IlpA from Vibrio vulnificus and similar lipoproteins; the type 2 periplasmic binding protein fold; This group includes the IlpA protein which has both structural and sequential homology to the MetQ family of substrate-binding protein, and thus belongs to the type 2 periplasmic binding fold protein superfamily (PBP2). The PBP2 proteins are typically comprised of two globular subdomains connected by a flexible hinge and bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap. The majority of PBP2 proteins function in the uptake of small soluble substrates in eubacteria and archaea.
Pssm-ID: 270316 Cd Length: 227 Bit Score: 189.87 E-value: 7.10e-60
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503125653 45 IIKIGTTGFFKDIVQEAKKDFESTSGYELEVIVFDDNVTPNIALDEGSIDVNFYQHVPFLDAFNKERGTNLVKYGEKGIA 124
Cdd:cd13598 1 PIKVGVIRGPDAQIWEVVQKVAKEKGLDVELVTFNDYAQPNEALAAGDLDANAFQHKPYLDAQIKARGYKLVIVGNTFVY 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503125653 125 CTyGIYSSKLKSLEEIPNGAKIGIANDSSNRTRGLRFLESNGFIKIKDGVDL-PTKLDVIENPKNLDLIEIDGPKLISSM 203
Cdd:cd13598 81 PI-GLYSKKIKSLAELPNGATVAIPNDPSNEGRALLLLQKEGLIKLKDGVGLlATVRDIAENPKKLKIVELDAGQLPRAL 159
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 503125653 204 EDVDAVVGYGIYMLLSGKDPKSAIIFDnEEDTKRYADVIVLREDNKNVEWVKHLEAALTNEKMRKYMDE 272
Cdd:cd13598 160 DDVDLAAINTDYASKAGLTPARDAIAQ-EDKRSPYANVIAVREDDKDAPWVKTLVQAYQSEEVKAFALK 227
|
|
| PBP2_lipoprotein_like_1 |
cd13600 |
Putative periplasmic-binding component of ABC-type methionine uptake transporter system-like; ... |
46-272 |
1.53e-59 |
|
Putative periplasmic-binding component of ABC-type methionine uptake transporter system-like; the type 2 periplasmic binding protein fold; This subgroup shares significant sequence homology with the periplasmic substrate-binding domain of ATP-binding cassette (ABC) transporter involved in uptake of methionine (MetQ). The members of the MetQ-like family include the 32-kilodalton lipoprotein (Tp32) from Treponema pallidum, the membrane-associated lipoprotein-9 GmpC from Staphylococcus aureus, and Toll-like receptor 2-activating lipoprotein IlpA from Vibrio vulnificus. They all function as a receptor for methionine. This substrate-binding domain belongs to the type 2 periplasmic binding fold protein superfamily (PBP2). The PBP2 proteins are typically comprised of two globular subdomains connected by a flexible hinge and bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap. The majority of PBP2 proteins function in the uptake of small soluble substrates in eubacteria and archaea.
Pssm-ID: 270318 Cd Length: 228 Bit Score: 189.08 E-value: 1.53e-59
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503125653 46 IKIGTTG-----FFKDIVQEAKKDfestsGYELEVIVFDDNVTPNIALDEGSIDVNFYQHVPFLDAFNKERGTNLVKyge 120
Cdd:cd13600 2 LKVATNSgpmteILEYIAAELAPD-----GITIEPVQVSDYVQANRAVAAGEIDANFFQHQPFMEQFNEANGFELVA--- 73
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503125653 121 kgIACTY----GIYSSKLKSLEEIPNGAKIGIANDSSNRTRGLRFLESNGFIKIKDGVDLPTKL--DVIENPKNLDLIEI 194
Cdd:cd13600 74 --VQPIYhwafGFYSKKYKSVEDLPDGAKVAIPNDPANQARALLLLQRAGLITLKPGVDPTTATlaDIVTNPKNLKFTEV 151
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 503125653 195 DGPKLISSMEDVDAVVGYGIYMLLSGKDPKSAIIFDnEEDTKRYADVIVLREDNKNVEWVKHLEAALTNEKMRKYMDE 272
Cdd:cd13600 152 DLLALPRALDDVDLAFGYPSYFDAAGLTPKDGILLE-EPDAKRFAIQLVAREDNKDSPKIKKLKEAFTDPRVRKFLET 228
|
|
| PBP2_lipoprotein_Gna1946 |
cd13599 |
The membrane-associated lipoprotein Gna1946 from Neisseria meningitidis; the type 2 ... |
46-272 |
5.48e-56 |
|
The membrane-associated lipoprotein Gna1946 from Neisseria meningitidis; the type 2 periplasmic binding protein fold; Gna1946 shares significant structural and sequence homology with the periplasmic substrate-binding domain of ATP-binding cassette (ABC) transporter involved in uptake of methionine (MetQ). The members of the MetQ-like family include the 32-kilodalton lipoprotein (Tp32) from Treponema pallidum, the membrane-associated lipoprotein-9 GmpC from Staphylococcus aureus, and Toll-like receptor 2-activating lipoprotein IlpA from Vibrio vulnificus. They all function as a receptor for methionine. This substrate-binding domain belongs to the type 2 periplasmic binding fold protein superfamily (PBP2). The PBP2 proteins are typically comprised of two globular subdomains connected by a flexible hinge and bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap. The majority of PBP2 proteins function in the uptake of small soluble substrates in eubacteria and archaea.
Pssm-ID: 270317 Cd Length: 228 Bit Score: 179.90 E-value: 5.48e-56
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503125653 46 IKIGTT-GFFKDIVQEAKKDFESTSGYELEVIVFDDNVTPNIALDEGSIDVNFYQHVPFLDAFNKERGTNLVKYGEKGIA 124
Cdd:cd13599 2 IVIGFTpGPYGDMVKNGVAPYLEKKGYEVKLKEFTDYVQPNNALANGEIDANVFQHKPYLDAFNKENGLDLVGIVQVPTP 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503125653 125 cTYGIYSSKLKSLEEIPNGAKIGIANDSSNRTRGLRFLESNGFIKIKDGVDlPTK---LDVIENPKNLDLIEIDGPKLIS 201
Cdd:cd13599 82 -PMGLYSNKHKSLEEVKDGATVAIPNDPSNLARALVMLQDLGWITLKDNID-PLKasvNDIAENPKNIKIVELEAAQLPR 159
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 503125653 202 SMEDVDAVVGYGIYMLLSGKDPKSAIIFdnEEDTKRYADVIVLREDNKNVEWVKHLEAALTNEKMRKYMDE 272
Cdd:cd13599 160 SLDDVDFAAIQGNFAISSGIKLTSALAL--EEMTDPYVNVVAVKTADKDKQFAKDVTAAYNSDAFKAYIHA 228
|
|
| PBP2_lipoprotein_GmpC |
cd13596 |
The periplasmic substrate-binding domain of the membrane-associated lipoprotein-9 GmpC; ... |
45-272 |
8.08e-51 |
|
The periplasmic substrate-binding domain of the membrane-associated lipoprotein-9 GmpC; contains the type 2 periplasmic-binding protein fold; This group includes the membrane-associated lipoprotein-9 from Staphylococcus aureus that binds the dipeptide glycylmethionine (GlyMet). The lipoprotein-9 has both structural and sequential homology to the MetQ family of substrate-binding protein. The GlyMet binding protein belongs to the type 2 periplasmic binding fold protein superfamily (PBP2). The PBP2 proteins are typically comprised of two globular subdomains connected by a flexible hinge and bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap. The majority of PBP2 proteins function in the uptake of small soluble substrates in eubacteria and archaea.
Pssm-ID: 270314 Cd Length: 230 Bit Score: 166.77 E-value: 8.08e-51
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503125653 45 IIKIGTTGFFKDIvQEAKKDFESTSGYELEVIVFDDNVTPNIALDEGSIDVNFYQHVPFLDAFNKERGTNLVKYGEKGIA 124
Cdd:cd13596 1 TVKIGVTGEDTDI-WDKIVEEAEEAGIKLELVNFSDYSQPNKALNDGDIDLNAFQHYAYLVQYNSKNNADLTAIGDTVIA 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503125653 125 cTYGIYSSKLKSLEEIPNGAKIGIANDSSNRTRGLRFLESNGFIKIK-DGVDLPTKLDVIENPKNLDLIEIDGPKLISSM 203
Cdd:cd13596 80 -PMGIYSKKITSVDELPDGAKIAIPNDPSNLSRALFILQAAGLIKLKkDAGDFPTVNDITENPKNLEIVPVDADQVYRAL 158
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 503125653 204 EDVDAVVGYGIYMLLSGKDPKSAIIF---DNEEDTKRYADVIVLREDNKNVEWVKHLEAALTNEKMRKYMDE 272
Cdd:cd13596 159 NDVDAAVINNTFALDAGLDPKKDAIFledPSSYGSKPYINLIAVREEDKDNPLYKKLVETYHDERVQKAVEE 230
|
|
| metQ |
PRK11063 |
D-methionine ABC transporter substrate-binding protein MetQ; |
3-255 |
1.03e-46 |
|
D-methionine ABC transporter substrate-binding protein MetQ;
Pssm-ID: 182939 [Multi-domain] Cd Length: 271 Bit Score: 157.62 E-value: 1.03e-46
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503125653 3 SKKIISLFSIIML--SIAMVGCsinanssddtssevDTKVEEKEIIKIGT-TGFFKDIVQEAKKDFESTSGYELEVIVFD 79
Cdd:PRK11063 2 AFKFKTFAAVGALigTLALVGC--------------GQDEKDPNHIKVGViVGAEQQVAEVAQKVAKEKYGLDVELVTFN 67
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503125653 80 DNVTPNIALDEGSIDVNFYQHVPFLDAFNKERGTNLVKYGEKGIACTYGiYSSKLKSLEEIPNGAKIGIANDSSNRTRGL 159
Cdd:PRK11063 68 DYVLPNEALSKGDIDANAFQHKPYLDQQIKDRGYKLVAVGNTFVYPIAG-YSKKIKSLDELQDGSQVAVPNDPTNLGRSL 146
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503125653 160 RFLESNGFIKIKDGVDL-PTKLDVIENPKNLDLIEIDGPKLISSMED--VDAVVGYGIYMLLSGKDPKSAIIFDNEEDTK 236
Cdd:PRK11063 147 LLLQKVGLIKLKDGVGLlPTVLDIVENPKNLKIVELEAPQLPRSLDDaqIALAVINTTYASQIGLTPAKDGIFVEDKDSP 226
|
250
....*....|....*....
gi 503125653 237 rYADVIVLREDNKNVEWVK 255
Cdd:PRK11063 227 -YVNLIVAREDNKDAENVK 244
|
|
| TIGR00363 |
TIGR00363 |
lipoprotein, YaeC family; This family of putative lipoproteins contains a consensus site for ... |
46-282 |
1.09e-44 |
|
lipoprotein, YaeC family; This family of putative lipoproteins contains a consensus site for lipoprotein signal sequence cleavage. Included in this family is the E. coli hypothetical protein yaeC. About half of the proteins between the noise and trusted cutoffs contain the consensus lipoprotein signature and may belong to this family. [Cell envelope, Other]
Pssm-ID: 129460 Cd Length: 258 Bit Score: 151.98 E-value: 1.09e-44
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503125653 46 IKIGT-TGFFKDIVQEAKKDFESTSGYELEVIVFDDNVTPNIALDEGSIDVNFYQHVPFLDAFNKERGTNLVKYGEKGIA 124
Cdd:TIGR00363 20 IKVGViSGAEQQVAEVAAKVAKEKYGLDVELVEFNDYALPNEAVSKGDLDANAFQHKPYLDQDAKAKGYKLVAVGNTFVY 99
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503125653 125 CTYGiYSSKLKSLEEIPNGAKIGIANDSSNRTRGLRFLESNGFIKIKDGVD-LPTKLDVIENPKNLDLIEIDGPKLISSM 203
Cdd:TIGR00363 100 PLAG-YSKKIKNVNELQDGAKVAVPNDPTNLGRALLLLQKQGLIKLKDGNGlLPTVLDIVENPKKLNITELETSQLPRAL 178
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503125653 204 ED--VDAVVGYGIYMLLSGKDPKSAIIFDNEEDTKrYADVIVLREDNKNVEWVKHLEAALTNEKMRKYMDEELEGAYIPA 281
Cdd:TIGR00363 179 DDpkVDLAVINTTYAGQVGLNPQDDGVFVEDKDSP-YVNIIVSREDNKDAENVKDFIQSYQSEEVYQAAQKHFNGGAVKG 257
|
.
gi 503125653 282 Y 282
Cdd:TIGR00363 258 W 258
|
|
| PRK09861 |
PRK09861 |
lipoprotein NlpA; |
11-282 |
2.52e-43 |
|
lipoprotein NlpA;
Pssm-ID: 182119 Cd Length: 272 Bit Score: 148.63 E-value: 2.52e-43
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503125653 11 SIIMLSIAMVGCsinanssddtssevDTKVEEKEIIKIGT-TGFFKDIVQEAKKDFESTSGYELEVIVFDDNVTPNIALD 89
Cdd:PRK09861 13 ALLLAGILLAGC--------------DQSSSDAKHIKVGViNGAEQDVAEVAKKVAKEKYGLDVELVGFSGSLLPNDATN 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503125653 90 EGSIDVNFYQHVPFLDAFNKERGTNLVKYGEKGIACTYGiYSSKLKSLEEIPNGAKIGIANDSSNRTRGLRFLESNGFIK 169
Cdd:PRK09861 79 HGELDANVFQHRPFLEQDNQAHGYKLVAVGNTFVFPMAG-YSKKIKTVAQIKEGATVAIPNDPTNLGRALLLLQKEKLIT 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503125653 170 IKDGVD-LPTKLDVIENPKNLDLIEIDGPKLISSMED--VDAVVGYGIYMLLSGKDPKSAIIFDnEEDTKRYADVIVLRE 246
Cdd:PRK09861 158 LKEGKGlLPTALDITDNPRHLQIMELEGAQLPRVLDDpkVDVAIISTTYIQQTGLSPVHDSVFI-EDKNSPYVNILVARE 236
|
250 260 270
....*....|....*....|....*....|....*.
gi 503125653 247 DNKNVEWVKHLEAALTNEKMRKYMDEELEGAYIPAY 282
Cdd:PRK09861 237 DNKNAENVKEFLQSYQSPEVAKAAETIFNGGAVPGW 272
|
|
| TauA |
COG0715 |
ABC-type nitrate/sulfonate/bicarbonate transport system, periplasmic component [Inorganic ion ... |
13-277 |
3.07e-09 |
|
ABC-type nitrate/sulfonate/bicarbonate transport system, periplasmic component [Inorganic ion transport and metabolism];
Pssm-ID: 440479 [Multi-domain] Cd Length: 297 Bit Score: 56.55 E-value: 3.07e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503125653 13 IMLSIAMVGCSINANSSDDTSsevdtkveekeiIKIGTT--------------GFFKDIvqeakkdfestsGYELEVIVF 78
Cdd:COG0715 3 ALAALALAACSAAAAAAEKVT------------LRLGWLpntdhaplyvakekGYFKKE------------GLDVELVEF 58
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503125653 79 DDNVTPNIALDEGSIDVNFYQHVPFLDAFNKerGTNLvkygeKGIACTY-----GIYS---SKLKSLEEIpNGAKIGIAN 150
Cdd:COG0715 59 AGGAAALEALAAGQADFGVAGAPPALAARAK--GAPV-----KAVAALSqsggnALVVrkdSGIKSLADL-KGKKVAVPG 130
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503125653 151 DSSNRTRGLRFLESNGFikikdgvdlptkldvieNPKNLDLIEIDGPKLISSME--DVDAVVGYGIYMLLSGKDPKSAII 228
Cdd:COG0715 131 GSTSHYLLRALLAKAGL-----------------DPKDVEIVNLPPPDAVAALLagQVDAAVVWEPFESQAEKKGGGRVL 193
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|..
gi 503125653 229 FDNEEDTKR-YADVIVLRED--NKNVEWVKHLEAALtnEKMRKYMDEELEGA 277
Cdd:COG0715 194 ADSADLVPGyPGDVLVASEDflEENPEAVKAFLRAL--LKAWAWAAANPDEA 243
|
|
| MalE |
COG2182 |
Maltose-binding periplasmic protein MalE [Carbohydrate transport and metabolism]; |
1-89 |
2.19e-03 |
|
Maltose-binding periplasmic protein MalE [Carbohydrate transport and metabolism];
Pssm-ID: 441785 [Multi-domain] Cd Length: 410 Bit Score: 39.16 E-value: 2.19e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503125653 1 MKSKKIISLFSIIMLSIAMVGCSiNANSSDDTSSEVDTKVEekeiIKIGTTGFFKDIVQEAKKDFESTSGYELEVIVFD- 79
Cdd:COG2182 1 MKRRLLAALALALALALALAACG-SGSSSSGSSSAAGAGGT----LTVWVDDDEAEALEEAAAAFEEEPGIKVKVVEVPw 75
|
90
....*....|
gi 503125653 80 DNVTPNIALD 89
Cdd:COG2182 76 DDLREKLTTA 85
|
|
| |
