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Conserved domains on  [gi|503237363|ref|WP_013472024|]
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amino-acid N-acetyltransferase [Mycolicibacterium gilvum]

Protein Classification

amino-acid N-acetyltransferase( domain architecture ID 10012979)

amino-acid N-acetyltransferase catalyzes the transfer of an acetyl group from acetyl-CoA to l-glutamate that is the first step of arginine biosynthesis; similar to Mycobacterium tuberculosis N-acetylglutamate synthase ArgA (Rv2747, NAGS) which can also use l-glutamine as a substrate

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PRK07922 PRK07922
amino-acid N-acetyltransferase;
8-173 7.30e-115

amino-acid N-acetyltransferase;


:

Pssm-ID: 236132 [Multi-domain]  Cd Length: 169  Bit Score: 322.64  E-value: 7.30e-115
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503237363   8 SDDRPVVRRARTSDVPHIKALVDIYA-GRILLEKNLVTLYESVQEFWVAEV-DGEVVGCGALHVLWSDLGEVRTVAVDPK 85
Cdd:PRK07922   2 AAGAITVRRARTSDVPAIKRLVDPYAqGRILLEKNLVTLYEAVQEFWVAEHlDGEVVGCGALHVMWEDLAEIRTVAVDPA 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503237363  86 VRGRGVGHAIVERLLTVAADLRLQRIFVLTFEVDFFARHGFQEIEGTPVTAEVYEEMCRSYDTGVAEFLDLSYVKPNILG 165
Cdd:PRK07922  82 ARGRGVGHAIVERLLDVARELGLSRVFVLTFEVEFFARHGFVEIDGTPVTPEVYAELLRSYDEGVAEFLDLSRVKPNTLG 161


                 ....*...
gi 503237363 166 NTRMLLLL 173
Cdd:PRK07922 162 NTRMLLHL 169
 
Name Accession Description Interval E-value
PRK07922 PRK07922
amino-acid N-acetyltransferase;
8-173 7.30e-115

amino-acid N-acetyltransferase;


Pssm-ID: 236132 [Multi-domain]  Cd Length: 169  Bit Score: 322.64  E-value: 7.30e-115
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503237363   8 SDDRPVVRRARTSDVPHIKALVDIYA-GRILLEKNLVTLYESVQEFWVAEV-DGEVVGCGALHVLWSDLGEVRTVAVDPK 85
Cdd:PRK07922   2 AAGAITVRRARTSDVPAIKRLVDPYAqGRILLEKNLVTLYEAVQEFWVAEHlDGEVVGCGALHVMWEDLAEIRTVAVDPA 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503237363  86 VRGRGVGHAIVERLLTVAADLRLQRIFVLTFEVDFFARHGFQEIEGTPVTAEVYEEMCRSYDTGVAEFLDLSYVKPNILG 165
Cdd:PRK07922  82 ARGRGVGHAIVERLLDVARELGLSRVFVLTFEVEFFARHGFVEIDGTPVTPEVYAELLRSYDEGVAEFLDLSRVKPNTLG 161


                 ....*...
gi 503237363 166 NTRMLLLL 173
Cdd:PRK07922 162 NTRMLLHL 169
ArgA COG1246
N-acetylglutamate synthase or related acetyltransferase, GNAT family [Amino acid transport and ...
 13-144 3.01e-37

N-acetylglutamate synthase or related acetyltransferase, GNAT family [Amino acid transport and metabolism]; N-acetylglutamate synthase or related acetyltransferase, GNAT family is part of the Pathway/BioSystem: Arginine biosynthesis


Pssm-ID: 440859 [Multi-domain]  Cd Length: 132  Bit Score: 124.72  E-value: 3.01e-37
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503237363  13 VVRRARTSDVPHIKALVDIYAgrilleknlvtLYESVQEFWVAEVDGEVVGCGALHVLWSDLGEVRTVAVDPKVRGRGVG 92
Cdd:COG1246    2 TIRPATPDDVPAILELIRPYA-----------LEEEIGEFWVAEEDGEIVGCAALHPLDEDLAELRSLAVHPDYRGRGIG 70

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....
gi 503237363  93 HAIVERLLTVAADLRLQRIFVLTFE--VDFFARHGFQEIEGTPVTAEVYEEMCR 144
Cdd:COG1246   71 RRLLEALLAEARELGLKRLFLLTTSaaIHFYEKLGFEEIDKEDLPYAKVWQRDS 124
Acetyltransf_7 pfam13508
Acetyltransferase (GNAT) domain; This domain catalyzes N-acetyltransferase reactions.
 51-128 9.61e-15

Acetyltransferase (GNAT) domain; This domain catalyzes N-acetyltransferase reactions.


Pssm-ID: 463905 [Multi-domain]  Cd Length: 84  Bit Score: 65.55  E-value: 9.61e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503237363   51 EFWVAEVDGEVVGCGALHVLWSDLGEVR-TVAVDPKVRGRGVGHAIVERLLTVAADLRLQRIFVLTFE--VDFFARHGFQ 127
Cdd:pfam13508   4 RFFVAEDDGKIVGFAALLPLDDEGALAElRLAVHPEYRGQGIGRALLEAAEAAAKEGGIKLLELETTNraAAFYEKLGFE 83


                  .
gi 503237363  128 E 128
Cdd:pfam13508  84 E 84
NAT_SF cd04301
N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer ...
 52-113 1.15e-10

N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; NAT (N-Acyltransferase) is a large superfamily of enzymes that mostly catalyze the transfer of an acyl group to a substrate and are implicated in a variety of functions, ranging from bacterial antibiotic resistance to circadian rhythms in mammals. Members include GCN5-related N-Acetyltransferases (GNAT) such as Aminoglycoside N-acetyltransferases, Histone N-acetyltransferase (HAT) enzymes, and Serotonin N-acetyltransferase, which catalyze the transfer of an acetyl group to a substrate. The kinetic mechanism of most GNATs involves the ordered formation of a ternary complex: the reaction begins with Acetyl Coenzyme A (AcCoA) binding, followed by binding of substrate, then direct transfer of the acetyl group from AcCoA to the substrate, followed by product and subsequent CoA release. Other family members include Arginine/ornithine N-succinyltransferase, Myristoyl-CoA: protein N-myristoyltransferase, and Acyl-homoserinelactone synthase which have a similar catalytic mechanism but differ in types of acyl groups transferred. Leucyl/phenylalanyl-tRNA-protein transferase and FemXAB nonribosomal peptidyltransferases which catalyze similar peptidyltransferase reactions are also included.


Pssm-ID: 173926 [Multi-domain]  Cd Length: 65  Bit Score: 54.59  E-value: 1.15e-10
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 503237363  52 FWVAEVDGEVVGCGALHVLWS--DLGEVRTVAVDPKVRGRGVGHAIVERLLTVAADLRLQRIFV 113
Cdd:cd04301    1 FLVAEDDGEIVGFASLSPDGSggDTAYIGDLAVLPEYRGKGIGSALLEAAEEEARERGAKRLRL 64
rimI TIGR01575
ribosomal-protein-alanine acetyltransferase; Members of this model belong to the GCN5-related ...
 51-129 1.39e-08

ribosomal-protein-alanine acetyltransferase; Members of this model belong to the GCN5-related N-acetyltransferase (GNAT) superfamily. This model covers prokarotes and the archaea. The seed contains a characterized accession for Gram negative E. coli. An untraceable characterized accession (PIR|S66013) for Gram positive B. subtilis scores well (205.0) in the full alignment. Characterized members are lacking in the archaea. Noise cutoff (72.4) was set to exclude M. loti paralog of rimI. Trusted cutoff (80.0) was set at next highest scoring member in the mini-database. [Protein synthesis, Ribosomal proteins: synthesis and modification]


Pssm-ID: 273701 [Multi-domain]  Cd Length: 131  Bit Score: 50.79  E-value: 1.39e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503237363   51 EFWVAEVDGEVVGCGALHVLWsDLGEVRTVAVDPKVRGRGVGHAIVERLLTVAADLRLQRIFVltfEV--------DFFA 122
Cdd:TIGR01575  32 CYLLARIGGKVVGYAGVQIVL-DEAHILNIAVKPEYQGQGIGRALLRELIDEAKGRGVNEIFL---EVrvsniaaqALYK 107


                  ....*..
gi 503237363  123 RHGFQEI 129
Cdd:TIGR01575 108 KLGFNEI 114
 
Name Accession Description Interval E-value
PRK07922 PRK07922
amino-acid N-acetyltransferase;
8-173 7.30e-115

amino-acid N-acetyltransferase;


Pssm-ID: 236132 [Multi-domain]  Cd Length: 169  Bit Score: 322.64  E-value: 7.30e-115
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503237363   8 SDDRPVVRRARTSDVPHIKALVDIYA-GRILLEKNLVTLYESVQEFWVAEV-DGEVVGCGALHVLWSDLGEVRTVAVDPK 85
Cdd:PRK07922   2 AAGAITVRRARTSDVPAIKRLVDPYAqGRILLEKNLVTLYEAVQEFWVAEHlDGEVVGCGALHVMWEDLAEIRTVAVDPA 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503237363  86 VRGRGVGHAIVERLLTVAADLRLQRIFVLTFEVDFFARHGFQEIEGTPVTAEVYEEMCRSYDTGVAEFLDLSYVKPNILG 165
Cdd:PRK07922  82 ARGRGVGHAIVERLLDVARELGLSRVFVLTFEVEFFARHGFVEIDGTPVTPEVYAELLRSYDEGVAEFLDLSRVKPNTLG 161


                 ....*...
gi 503237363 166 NTRMLLLL 173
Cdd:PRK07922 162 NTRMLLHL 169
PRK07757 PRK07757
N-acetyltransferase;
14-130 3.11e-47

N-acetyltransferase;


Pssm-ID: 236088 [Multi-domain]  Cd Length: 152  Bit Score: 150.73  E-value: 3.11e-47
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503237363  14 VRRARTSDVPHIKALVDIYAGR-ILLEKNLVTLYESVQEFWVAEVDGEVVGCGALHVLWSDLGEVRTVAVDPKVRGRGVG 92
Cdd:PRK07757   4 IRKARLSDVKAIHALINVYAKKgLMLPRSLDELYENIRDFYVAEEEGEIVGCCALHILWEDLAEIRSLAVSEDYRGQGIG 83

                         90       100       110
                 ....*....|....*....|....*....|....*...
gi 503237363  93 HAIVERLLTVAADLRLQRIFVLTFEVDFFARHGFQEIE 130
Cdd:PRK07757  84 RMLVEACLEEARELGVKRVFALTYQPEFFEKLGFREVD 121
ArgA COG1246
N-acetylglutamate synthase or related acetyltransferase, GNAT family [Amino acid transport and ...
 13-144 3.01e-37

N-acetylglutamate synthase or related acetyltransferase, GNAT family [Amino acid transport and metabolism]; N-acetylglutamate synthase or related acetyltransferase, GNAT family is part of the Pathway/BioSystem: Arginine biosynthesis


Pssm-ID: 440859 [Multi-domain]  Cd Length: 132  Bit Score: 124.72  E-value: 3.01e-37
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503237363  13 VVRRARTSDVPHIKALVDIYAgrilleknlvtLYESVQEFWVAEVDGEVVGCGALHVLWSDLGEVRTVAVDPKVRGRGVG 92
Cdd:COG1246    2 TIRPATPDDVPAILELIRPYA-----------LEEEIGEFWVAEEDGEIVGCAALHPLDEDLAELRSLAVHPDYRGRGIG 70

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....
gi 503237363  93 HAIVERLLTVAADLRLQRIFVLTFE--VDFFARHGFQEIEGTPVTAEVYEEMCR 144
Cdd:COG1246   71 RRLLEALLAEARELGLKRLFLLTTSaaIHFYEKLGFEEIDKEDLPYAKVWQRDS 124
PRK12308 PRK12308
argininosuccinate lyase;
13-126 8.07e-24

argininosuccinate lyase;


Pssm-ID: 183425 [Multi-domain]  Cd Length: 614  Bit Score: 97.16  E-value: 8.07e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503237363  13 VVRRARTSDVPHIKALVDIYAGrilLEKNL----VTLYESVQEFWVAEVDGEVVGCGALHVLWSDLGEVRTVAVDPKVRG 88
Cdd:PRK12308 465 KVRPARLTDIDAIEGMVAYWAG---LGENLprsrNELVRDIGSFAVAEHHGEVTGCASLYIYDSGLAEIRSLGVEAGWQV 541

                         90       100       110
                 ....*....|....*....|....*....|....*...
gi 503237363  89 RGVGHAIVERLLTVAADLRLQRIFVLTFEVDFFARHGF 126
Cdd:PRK12308 542 QGQGSALVQYLVEKARQMAIKKVFVLTRVPEFFMKQGF 579
yhbS COG3153
Predicted N-acetyltransferase YhbS [General function prediction only];
14-140 1.59e-16

Predicted N-acetyltransferase YhbS [General function prediction only];


Pssm-ID: 442387 [Multi-domain]  Cd Length: 142  Bit Score: 72.04  E-value: 1.59e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503237363  14 VRRARTSDVPHIKALVDIYAGRILLEKNLVTLYESVQ--EFWVAEVDGEVVGCGALHVLW----SDLGEVRTVAVDPKVR 87
Cdd:COG3153    1 IRPATPEDAEAIAALLRAAFGPGREAELVDRLREDPAagLSLVAEDDGEIVGHVALSPVDidgeGPALLLGPLAVDPEYR 80

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 503237363  88 GRGVGHAIVERLLTVAADLRLQRIFVLTFE--VDFFARHGFQEIEGTPVTAEVYE 140
Cdd:COG3153   81 GQGIGRALMRAALEAARERGARAVVLLGDPslLPFYERFGFRPAGELGLTLGPDE 135
Acetyltransf_7 pfam13508
Acetyltransferase (GNAT) domain; This domain catalyzes N-acetyltransferase reactions.
 51-128 9.61e-15

Acetyltransferase (GNAT) domain; This domain catalyzes N-acetyltransferase reactions.


Pssm-ID: 463905 [Multi-domain]  Cd Length: 84  Bit Score: 65.55  E-value: 9.61e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503237363   51 EFWVAEVDGEVVGCGALHVLWSDLGEVR-TVAVDPKVRGRGVGHAIVERLLTVAADLRLQRIFVLTFE--VDFFARHGFQ 127
Cdd:pfam13508   4 RFFVAEDDGKIVGFAALLPLDDEGALAElRLAVHPEYRGQGIGRALLEAAEAAAKEGGIKLLELETTNraAAFYEKLGFE 83


                  .
gi 503237363  128 E 128
Cdd:pfam13508  84 E 84
PhnO COG0454
N-acetyltransferase, GNAT superfamily (includes histone acetyltransferase HPA2) [Transcription, ...
 47-130 1.94e-14

N-acetyltransferase, GNAT superfamily (includes histone acetyltransferase HPA2) [Transcription, General function prediction only];


Pssm-ID: 440222 [Multi-domain]  Cd Length: 136  Bit Score: 66.23  E-value: 1.94e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503237363  47 ESVQEFWVAEVDGEVVGCGALHVLWSDLGEVRTVAVDPKVRGRGVGHAIVERLLTVAADLRLQRIFVLTFE-----VDFF 121
Cdd:COG0454   31 LAGAEFIAVDDKGEPIGFAGLRRLDDKVLELKRLYVLPEYRGKGIGKALLEALLEWARERGCTALELDTLDgnpaaIRFY 110


                 ....*....
gi 503237363 122 ARHGFQEIE 130
Cdd:COG0454  111 ERLGFKEIE 119
Acetyltransf_1 pfam00583
Acetyltransferase (GNAT) family; This family contains proteins with N-acetyltransferase ...
 52-126 3.81e-14

Acetyltransferase (GNAT) family; This family contains proteins with N-acetyltransferase functions such as Elp3-related proteins.


Pssm-ID: 395465 [Multi-domain]  Cd Length: 116  Bit Score: 65.23  E-value: 3.81e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503237363   52 FWVAEVDGEVVGCGALHVLWSDL--GEVRTVAVDPKVRGRGVGHAIVERLLTVAADLRLQRIFVLTFE-----VDFFARH 124
Cdd:pfam00583  35 FFVAEEDGELVGFASLSIIDDEPpvGEIEGLAVAPEYRGKGIGTALLQALLEWARERGCERIFLEVAAdnlaaIALYEKL 114


                  ..
gi 503237363  125 GF 126
Cdd:pfam00583 115 GF 116
MnaT COG1247
L-amino acid N-acyltransferase MnaT [Amino acid transport and metabolism];
13-129 9.56e-13

L-amino acid N-acyltransferase MnaT [Amino acid transport and metabolism];


Pssm-ID: 440860 [Multi-domain]  Cd Length: 163  Bit Score: 62.32  E-value: 9.56e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503237363  13 VVRRARTSDVPhikALVDIYA-----GRILLEKNLVTL----------YESVQEFWVAEVDGEVVGCGALHVLWSDLGEV 77
Cdd:COG1247    3 TIRPATPEDAP---AIAAIYNeaiaeGTATFETEPPSEeereawfaaiLAPGRPVLVAEEDGEVVGFASLGPFRPRPAYR 79

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 503237363  78 RT----VAVDPKVRGRGVGHAIVERLLTVAADLRLQRIFVLTFE-----VDFFARHGFQEI 129
Cdd:COG1247   80 GTaeesIYVDPDARGRGIGRALLEALIERARARGYRRLVAVVLAdneasIALYEKLGFEEV 140
PLN02825 PLN02825
amino-acid N-acetyltransferase
 7-133 1.06e-12

amino-acid N-acetyltransferase


Pssm-ID: 215441 [Multi-domain]  Cd Length: 515  Bit Score: 64.79  E-value: 1.06e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503237363   7 ASDDRPVVRRARTSDVPHIKALVD-IYAGRILLEKNLVTLYESVQEFWVAEVDGEVVGCGALHVLWSD-LGEVRTVAVDP 84
Cdd:PLN02825 363 ASDMYEGTRMARVEDLAGIRQIIRpLEESGILVRRTDEELLRALDSFVVVEREGSIIACAALFPFFEEkCGEVAAIAVSP 442

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|..
gi 503237363  85 KVRGRGVGHAIVERLLTVAADLRLQRIFVLTFEV-DFFARHGFQE--IEGTP 133
Cdd:PLN02825 443 ECRGQGQGDKLLDYIEKKAASLGLEKLFLLTTRTaDWFVRRGFSEcsIESLP 494
ElaA COG2153
Predicted N-acyltransferase, GNAT family [General function prediction only];
54-141 2.26e-12

Predicted N-acyltransferase, GNAT family [General function prediction only];


Pssm-ID: 441756 [Multi-domain]  Cd Length: 134  Bit Score: 60.97  E-value: 2.26e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503237363  54 VAEVDGEVVGCGALHVLWSDLGEVRTVAVDPKVRGRGVGHAIVERLLTVAADLRLQRIFV-----LtfeVDFFARHGFQe 128
Cdd:COG2153   38 LAYDDGELVATARLLPPGDGEAKIGRVAVLPEYRGQGLGRALMEAAIEEARERGARRIVLsaqahA---VGFYEKLGFV- 113

                         90
                 ....*....|...
gi 503237363 129 iegtpVTAEVYEE 141
Cdd:COG2153  114 -----PVGEEFLE 121
PRK05279 PRK05279
N-acetylglutamate synthase; Validated
 14-130 2.38e-12

N-acetylglutamate synthase; Validated


Pssm-ID: 235386 [Multi-domain]  Cd Length: 441  Bit Score: 63.63  E-value: 2.38e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503237363  14 VRRARTSDVPHIKALVD--------IYAGRILLEKNlvtlyesVQEFWVAEVDGEVVGCGALHVL-WSDLGEVRTVAVDP 84
Cdd:PRK05279 297 LRRATIDDVGGILELIRpleeqgilVRRSREQLERE-------IDKFTVIERDGLIIGCAALYPFpEEKMGEMACLAVHP 369

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*..
gi 503237363  85 KVRGRGVGHAIVERLLTVAADLRLQRIFVLTFE-VDFFARHGFQEIE 130
Cdd:PRK05279 370 DYRGSGRGERLLKRIEQRARQLGLKRLFVLTTRtAHWFLERGFVPVD 416
NAT_SF cd04301
N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer ...
 52-113 1.15e-10

N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; NAT (N-Acyltransferase) is a large superfamily of enzymes that mostly catalyze the transfer of an acyl group to a substrate and are implicated in a variety of functions, ranging from bacterial antibiotic resistance to circadian rhythms in mammals. Members include GCN5-related N-Acetyltransferases (GNAT) such as Aminoglycoside N-acetyltransferases, Histone N-acetyltransferase (HAT) enzymes, and Serotonin N-acetyltransferase, which catalyze the transfer of an acetyl group to a substrate. The kinetic mechanism of most GNATs involves the ordered formation of a ternary complex: the reaction begins with Acetyl Coenzyme A (AcCoA) binding, followed by binding of substrate, then direct transfer of the acetyl group from AcCoA to the substrate, followed by product and subsequent CoA release. Other family members include Arginine/ornithine N-succinyltransferase, Myristoyl-CoA: protein N-myristoyltransferase, and Acyl-homoserinelactone synthase which have a similar catalytic mechanism but differ in types of acyl groups transferred. Leucyl/phenylalanyl-tRNA-protein transferase and FemXAB nonribosomal peptidyltransferases which catalyze similar peptidyltransferase reactions are also included.


Pssm-ID: 173926 [Multi-domain]  Cd Length: 65  Bit Score: 54.59  E-value: 1.15e-10
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 503237363  52 FWVAEVDGEVVGCGALHVLWS--DLGEVRTVAVDPKVRGRGVGHAIVERLLTVAADLRLQRIFV 113
Cdd:cd04301    1 FLVAEDDGEIVGFASLSPDGSggDTAYIGDLAVLPEYRGKGIGSALLEAAEEEARERGAKRLRL 64
RimI COG0456
Ribosomal protein S18 acetylase RimI and related acetyltransferases [Translation, ribosomal ...
 63-130 3.51e-09

Ribosomal protein S18 acetylase RimI and related acetyltransferases [Translation, ribosomal structure and biogenesis];


Pssm-ID: 440224 [Multi-domain]  Cd Length: 92  Bit Score: 51.19  E-value: 3.51e-09
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 503237363  63 GCGALHVLWS-DLGEVRTVAVDPKVRGRGVGHAIVERLLTVAADLRLQRIFVLTFE-----VDFFARHGFQEIE 130
Cdd:COG0456    1 GFALLGLVDGgDEAEIEDLAVDPEYRGRGIGRALLEAALERARERGARRLRLEVREdneaaIALYEKLGFEEVG 74
rimI TIGR01575
ribosomal-protein-alanine acetyltransferase; Members of this model belong to the GCN5-related ...
 51-129 1.39e-08

ribosomal-protein-alanine acetyltransferase; Members of this model belong to the GCN5-related N-acetyltransferase (GNAT) superfamily. This model covers prokarotes and the archaea. The seed contains a characterized accession for Gram negative E. coli. An untraceable characterized accession (PIR|S66013) for Gram positive B. subtilis scores well (205.0) in the full alignment. Characterized members are lacking in the archaea. Noise cutoff (72.4) was set to exclude M. loti paralog of rimI. Trusted cutoff (80.0) was set at next highest scoring member in the mini-database. [Protein synthesis, Ribosomal proteins: synthesis and modification]


Pssm-ID: 273701 [Multi-domain]  Cd Length: 131  Bit Score: 50.79  E-value: 1.39e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503237363   51 EFWVAEVDGEVVGCGALHVLWsDLGEVRTVAVDPKVRGRGVGHAIVERLLTVAADLRLQRIFVltfEV--------DFFA 122
Cdd:TIGR01575  32 CYLLARIGGKVVGYAGVQIVL-DEAHILNIAVKPEYQGQGIGRALLRELIDEAKGRGVNEIFL---EVrvsniaaqALYK 107


                  ....*..
gi 503237363  123 RHGFQEI 129
Cdd:TIGR01575 108 KLGFNEI 114
Acetyltransf_10 pfam13673
Acetyltransferase (GNAT) domain; This family contains proteins with N-acetyltransferase ...
 52-130 8.56e-07

Acetyltransferase (GNAT) domain; This family contains proteins with N-acetyltransferase functions such as Elp3-related proteins.


Pssm-ID: 463953 [Multi-domain]  Cd Length: 128  Bit Score: 45.72  E-value: 8.56e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503237363   52 FWVAEVDGEVVGCGALhvlwSDLGEVRTVAVDPKVRGRGVGHAIVERLLTVAADLRLQRIFVL----TFEVDFFARHGFQ 127
Cdd:pfam13673  33 FFVAFEGGQIVGVIAL----RDRGHISLLFVDPDYQGQGIGKALLEAVEDYAEKDGIKLSELTvnasPYAVPFYEKLGFR 108


                  ...
gi 503237363  128 EIE 130
Cdd:pfam13673 109 ATG 111
Acetyltransf_9 pfam13527
Acetyltransferase (GNAT) domain; This domain catalyzes N-acetyltransferase reactions.
 14-126 9.72e-06

Acetyltransferase (GNAT) domain; This domain catalyzes N-acetyltransferase reactions.


Pssm-ID: 404421 [Multi-domain]  Cd Length: 124  Bit Score: 42.94  E-value: 9.72e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503237363   14 VRRARTSDVPHIKALVD-----------IYAGRILLEKNlvtlyesvqEFWVAEVDGEVVGCGALHVL-WSDLGEVRT-- 79
Cdd:pfam13527   1 IRPLTEDEFDEVLRLLEyafqdedspelREYFRPLLEEG---------RVLGAFDDGELVSTLALYPFeLNVPGKTLPaa 71

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|..
gi 503237363   80 ----VAVDPKVRGRGVGHAIVERLLTVAADlRLQRIFVLT-FEVDFFARHGF 126
Cdd:pfam13527  72 gitgVATYPEYRGRGVMSRLLRRSLEEMRE-RGVPLSFLYpSSYPIYRRFGY 122
COG3393 COG3393
Predicted acetyltransferase, GNAT family [General function prediction only];
60-129 1.29e-05

Predicted acetyltransferase, GNAT family [General function prediction only];


Pssm-ID: 442620 [Multi-domain]  Cd Length: 86  Bit Score: 41.82  E-value: 1.29e-05
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 503237363  60 EVVGCGALHVLWSDLGEVRTVAVDPKVRGRGVGHAIVERLLTVAADLRLQRIFVLTFE-----VDFFARHGFQEI 129
Cdd:COG3393    1 ELVAMAGVRAESPGVAEISGVYTHPEYRGRGLASALVAALAREALARGARTPFLYVDAdnpaaRRLYERLGFRPV 75
COG3818 COG3818
Predicted N-acetyltransferase, GNAT superfamily [General function prediction only];
13-129 1.10e-04

Predicted N-acetyltransferase, GNAT superfamily [General function prediction only];


Pssm-ID: 443030 [Multi-domain]  Cd Length: 168  Bit Score: 40.69  E-value: 1.10e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503237363  13 VVRRARTSDVPHIKALVDIYAGRI--LLEKNLVTLYESVQEFWVAEVDGEVVG------CGALHV----LW-----SDLG 75
Cdd:COG3818    6 VIRDAREHDLDAVLALNNAAVPAVspLDAARLARLHEQAAYARVAEVDGEVAGfllafgPGADYDspnyRWfaeryDNFL 85

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 503237363  76 EVRTVAVDPKVRGRGVGHAIVERLLTVAadlRLQRIFVLTFEVD----------FFARHGFQEI 129
Cdd:COG3818   86 YIDRIVVAPSARGRGLGRALYADVFSYA---RARGVPRVTCEVNleppnpgslaFHARLGFREV 146
YidJ COG2388
Predicted acetyltransferase, GNAT superfamily [General function prediction only];
54-124 8.29e-04

Predicted acetyltransferase, GNAT superfamily [General function prediction only];


Pssm-ID: 441953 [Multi-domain]  Cd Length: 88  Bit Score: 36.67  E-value: 8.29e-04
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 503237363  54 VAEVDGEVVGcgalHVLWSDLGEVRTV---AVDPKVRGRGVGHAIVERLLTVAADLRLQRIFVLTFEVDFFARH 124
Cdd:COG2388   13 ELEVDGELAG----ELTYRLEGGVIIIthtEVPPALRGQGIASALVEAALDDARERGLKVVPLCPFVAAYFERH 82
PRK03624 PRK03624
putative acetyltransferase; Provisional
 52-99 5.05e-03

putative acetyltransferase; Provisional


Pssm-ID: 235142 [Multi-domain]  Cd Length: 140  Bit Score: 35.67  E-value: 5.05e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....
gi 503237363  52 FWVAEVDGEVVGC------GalHVLWsdlgeVRTVAVDPKVRGRGVGHAIVERL 99
Cdd:PRK03624  47 FLVAEVGGEVVGTvmggydG--HRGW-----AYYLAVHPDFRGRGIGRALVARL 93
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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