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Conserved domains on  [gi|503243763|ref|WP_013478424|]
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RodZ family helix-turn-helix domain-containing protein [Asticcacaulis excentricus]

Protein Classification

helix-turn-helix domain-containing protein( domain architecture ID 11444431)

helix-turn-helix (HTH) domain-containing protein with an XRE (Xenobiotic Response Element) family HTH domain, binds DNA and may function as a transcriptional regulator

CATH:  1.10.10.10
Gene Ontology:  GO:0003677
PubMed:  15808743|2644244|8831795
SCOP:  4000362

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
RodZ COG1426
Cytoskeletal protein RodZ, contains Xre-like HTH and DUF4115 domains [Cell cycle control, cell ...
 49-119 1.96e-22

Cytoskeletal protein RodZ, contains Xre-like HTH and DUF4115 domains [Cell cycle control, cell division, chromosome partitioning];


:

Pssm-ID: 441035 [Multi-domain]  Cd Length: 71  Bit Score: 89.86  E-value: 1.96e-22
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 503243763  49 SDPETLGNILRSTREAQGFSLEYMADITRVRRSYLEALEEATYDRLPSRAFSIGFVKAYAKALGLDEESLA 119
Cdd:COG1426    1 EALETIGELLRQAREAKGLSLEDVAERTKISVSYLEAIEEGDFDALPGPVYVRGFLRSYARALGLDPEELL 71
 
Name Accession Description Interval E-value
RodZ COG1426
Cytoskeletal protein RodZ, contains Xre-like HTH and DUF4115 domains [Cell cycle control, cell ...
 49-119 1.96e-22

Cytoskeletal protein RodZ, contains Xre-like HTH and DUF4115 domains [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 441035 [Multi-domain]  Cd Length: 71  Bit Score: 89.86  E-value: 1.96e-22
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 503243763  49 SDPETLGNILRSTREAQGFSLEYMADITRVRRSYLEALEEATYDRLPSRAFSIGFVKAYAKALGLDEESLA 119
Cdd:COG1426    1 EALETIGELLRQAREAKGLSLEDVAERTKISVSYLEAIEEGDFDALPGPVYVRGFLRSYARALGLDPEELL 71
HTH_25 pfam13413
Helix-turn-helix domain; This domain is a helix-turn-helix domain that probably binds to DNA.
 57-118 5.02e-19

Helix-turn-helix domain; This domain is a helix-turn-helix domain that probably binds to DNA.


Pssm-ID: 433187 [Multi-domain]  Cd Length: 62  Bit Score: 80.23  E-value: 5.02e-19
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 503243763   57 ILRSTREAQGFSLEYMADITRVRRSYLEALEEATYDRLPSRAFSIGFVKAYAKALGLDEESL 118
Cdd:pfam13413   1 RLRAAREARGLSLEDVAERTKIRPRYLEALEEDDFDALPEPVYARGFLRSYARALGLDPEEL 62
HTH_XRE smart00530
Helix-turn-helix XRE-family like proteins;
58-118 5.93e-06

Helix-turn-helix XRE-family like proteins;


Pssm-ID: 197775 [Multi-domain]  Cd Length: 56  Bit Score: 43.28  E-value: 5.93e-06
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 503243763    58 LRSTREAQGFSLEYMADITRVRRSYLEALEEATydrlpsRAFSIGFVKAYAKALGLDEESL 118
Cdd:smart00530   2 LKELREEKGLTQEELAEKLGVSRSTLSRIENGK------RKPSLETLKKLAKALGVSLDEL 56
HTH_XRE cd00093
Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the ...
 55-118 1.86e-05

Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators.


Pssm-ID: 238045 [Multi-domain]  Cd Length: 58  Bit Score: 41.77  E-value: 1.86e-05
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 503243763  55 GNILRSTREAQGFSLEYMADITRVRRSYLEALEEATydrlpsRAFSIGFVKAYAKALGLDEESL 118
Cdd:cd00093    1 GERLKELRKEKGLTQEELAEKLGVSRSTISRIENGK------RNPSLETLEKLAKALGVSLDEL 58
 
Name Accession Description Interval E-value
RodZ COG1426
Cytoskeletal protein RodZ, contains Xre-like HTH and DUF4115 domains [Cell cycle control, cell ...
 49-119 1.96e-22

Cytoskeletal protein RodZ, contains Xre-like HTH and DUF4115 domains [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 441035 [Multi-domain]  Cd Length: 71  Bit Score: 89.86  E-value: 1.96e-22
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 503243763  49 SDPETLGNILRSTREAQGFSLEYMADITRVRRSYLEALEEATYDRLPSRAFSIGFVKAYAKALGLDEESLA 119
Cdd:COG1426    1 EALETIGELLRQAREAKGLSLEDVAERTKISVSYLEAIEEGDFDALPGPVYVRGFLRSYARALGLDPEELL 71
HTH_25 pfam13413
Helix-turn-helix domain; This domain is a helix-turn-helix domain that probably binds to DNA.
 57-118 5.02e-19

Helix-turn-helix domain; This domain is a helix-turn-helix domain that probably binds to DNA.


Pssm-ID: 433187 [Multi-domain]  Cd Length: 62  Bit Score: 80.23  E-value: 5.02e-19
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 503243763   57 ILRSTREAQGFSLEYMADITRVRRSYLEALEEATYDRLPSRAFSIGFVKAYAKALGLDEESL 118
Cdd:pfam13413   1 RLRAAREARGLSLEDVAERTKIRPRYLEALEEDDFDALPEPVYARGFLRSYARALGLDPEEL 62
HTH_19 pfam12844
Helix-turn-helix domain; Members of this family contains a DNA-binding helix-turn-helix domain. ...
 55-121 1.21e-06

Helix-turn-helix domain; Members of this family contains a DNA-binding helix-turn-helix domain. This family contains many example antitoxins from bacterial toxin-antitoxin systems. These antitoxins are likely to be DNA-binding domains.


Pssm-ID: 463728 [Multi-domain]  Cd Length: 64  Bit Score: 45.36  E-value: 1.21e-06
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 503243763   55 GNILRSTREAQGFSLEYMADITRVRRSYLEALEEATYDrlpsraFSIGFVKAYAKALGLDEESLADL 121
Cdd:pfam12844   1 GERLRKAREERGLTQEELAERLGISRSQLSAIENGKSV------PPAETLYKIAELLGVPANWLLQG 61
HTH_XRE smart00530
Helix-turn-helix XRE-family like proteins;
58-118 5.93e-06

Helix-turn-helix XRE-family like proteins;


Pssm-ID: 197775 [Multi-domain]  Cd Length: 56  Bit Score: 43.28  E-value: 5.93e-06
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 503243763    58 LRSTREAQGFSLEYMADITRVRRSYLEALEEATydrlpsRAFSIGFVKAYAKALGLDEESL 118
Cdd:smart00530   2 LKELREEKGLTQEELAEKLGVSRSTLSRIENGK------RKPSLETLKKLAKALGVSLDEL 56
HTH_XRE cd00093
Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the ...
 55-118 1.86e-05

Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators.


Pssm-ID: 238045 [Multi-domain]  Cd Length: 58  Bit Score: 41.77  E-value: 1.86e-05
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 503243763  55 GNILRSTREAQGFSLEYMADITRVRRSYLEALEEATydrlpsRAFSIGFVKAYAKALGLDEESL 118
Cdd:cd00093    1 GERLKELRKEKGLTQEELAEKLGVSRSTISRIENGK------RNPSLETLEKLAKALGVSLDEL 58
HipB COG1396
Transcriptional regulator, contains XRE-family HTH domain [Transcription];
48-125 7.37e-05

Transcriptional regulator, contains XRE-family HTH domain [Transcription];


Pssm-ID: 441006 [Multi-domain]  Cd Length: 83  Bit Score: 41.14  E-value: 7.37e-05
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 503243763  48 ASDPETLGNILRSTREAQGFSLEYMADITRVRRSYLEALEEATydrlpsRAFSIGFVKAYAKALGLdeeSLADLFKRS 125
Cdd:COG1396    2 STLKKALGERLRELRKARGLTQEELAERLGVSRSTISRIERGR------RNPSLETLLKLAKALGV---SLDELLGGA 70
HTH_3 pfam01381
Helix-turn-helix; This large family of DNA binding helix-turn helix proteins includes Cro and ...
 58-118 4.95e-04

Helix-turn-helix; This large family of DNA binding helix-turn helix proteins includes Cro and CI. Within the protein Swiss:Q5F9C2, the full protein fold incorporates a helix-turn-helix motif, but the function of this member is unlikely to be that of a DNA-binding regulator, the function of most other members, so is not necessarily characteriztic of the whole family.


Pssm-ID: 460181 [Multi-domain]  Cd Length: 55  Bit Score: 37.91  E-value: 4.95e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 503243763   58 LRSTREAQGFSLEYMADITRVRRSYLEALEEATydrlpsRAFSIGFVKAYAKALGLDEESL 118
Cdd:pfam01381   1 LKELREELGLSQEELAEKLGVSRSTISKIENGK------REPSLETLKKLAEALGVSLDEL 55
HTH_31 pfam13560
Helix-turn-helix domain; This domain is a helix-turn-helix domain that probably binds to DNA.
 54-121 2.10e-03

Helix-turn-helix domain; This domain is a helix-turn-helix domain that probably binds to DNA.


Pssm-ID: 433309 [Multi-domain]  Cd Length: 64  Bit Score: 36.35  E-value: 2.10e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 503243763   54 LGNILRSTREAQGFSLEYMADITRVRRSYLEALEEATYDRlpsraFSIGFVKAYAKALGLDEESLADL 121
Cdd:pfam13560   2 LGARLRRLRERAGLSQEALARRLGVSRSTLSRLETGRRGR-----PSPAVVERLARALGVDGAERAEL 64
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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