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Conserved domains on  [gi|503243781|ref|WP_013478442|]
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molybdenum cofactor biosynthesis protein MoaE [Asticcacaulis excentricus]

Protein Classification

molybdenum cofactor biosynthesis protein MoaE( domain architecture ID 10001056)

molybdenum cofactor biosynthesis protein MoaE serves as the catalytic subunit of the molybdopterin synthase complex, which catalyzes the conversion of precursor Z into molybdopterin

CATH:  3.90.1170.40
EC:  2.8.1.12
Gene Ontology:  GO:0006777|GO:0030366
PubMed:  35744859
SCOP:  4001136

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
MoaE COG0314
Molybdopterin synthase catalytic subunit MoaE [Coenzyme transport and metabolism]; ...
 8-145 1.10e-51

Molybdopterin synthase catalytic subunit MoaE [Coenzyme transport and metabolism]; Molybdopterin synthase catalytic subunit MoaE is part of the Pathway/BioSystem: Molybdopterin biosynthesis


:

Pssm-ID: 440083 [Multi-domain]  Cd Length: 143  Bit Score: 161.12  E-value: 1.10e-51
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503243781   8 LLPQALDGQALYGRFVAANRGAGAIVTFSGRVRGETTEGAVSHLWLDWYPGMSEQSLKAIAEAAAERFDVQALLVAHRCG 87
Cdd:COG0314    6 VTEEPFDLAAELAALRASDPEAGAVVTFVGTVRDHNDGRRVTALEYEAYPPMAEKELAEIAEEAAERWGLLDVAVIHRVG 85

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 503243781  88 AVKAEDEIVFVVAASAHRRAAFEAADYLMDRLKSEAALWKREVGPGFARWVEPTATDA 145
Cdd:COG0314   86 RLEPGEPIVLVAVSSAHRKEAFEACRFLIDRLKTRAPIWKKEIFEDGEEWVEARSSDD 143
 
Name Accession Description Interval E-value
MoaE COG0314
Molybdopterin synthase catalytic subunit MoaE [Coenzyme transport and metabolism]; ...
 8-145 1.10e-51

Molybdopterin synthase catalytic subunit MoaE [Coenzyme transport and metabolism]; Molybdopterin synthase catalytic subunit MoaE is part of the Pathway/BioSystem: Molybdopterin biosynthesis


Pssm-ID: 440083 [Multi-domain]  Cd Length: 143  Bit Score: 161.12  E-value: 1.10e-51
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503243781   8 LLPQALDGQALYGRFVAANRGAGAIVTFSGRVRGETTEGAVSHLWLDWYPGMSEQSLKAIAEAAAERFDVQALLVAHRCG 87
Cdd:COG0314    6 VTEEPFDLAAELAALRASDPEAGAVVTFVGTVRDHNDGRRVTALEYEAYPPMAEKELAEIAEEAAERWGLLDVAVIHRVG 85

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 503243781  88 AVKAEDEIVFVVAASAHRRAAFEAADYLMDRLKSEAALWKREVGPGFARWVEPTATDA 145
Cdd:COG0314   86 RLEPGEPIVLVAVSSAHRKEAFEACRFLIDRLKTRAPIWKKEIFEDGEEWVEARSSDD 143
MoaE cd00756
MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor ...
 13-138 3.78e-44

MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and eukaryotes. Moco contains a tricyclic pyranopterin, termed molybdopterin (MPT), which carries the cis-dithiolene group responsible for molybdenum ligation. This dithiolene group is generated by MPT synthase in the second major step in Moco biosynthesis. MPT synthase is a heterotetramer consisting of two large (MoaE) and two small (MoaD) subunits.


Pssm-ID: 238385 [Multi-domain]  Cd Length: 124  Bit Score: 141.50  E-value: 3.78e-44
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503243781  13 LDGQALYGRFvaANRGAGAIVTFSGRVRGETTEGAVSHLWLDWYPGMSEQSLKAIAEAAAERFDVQALLVAHRCGAVKAE 92
Cdd:cd00756    1 FDLAELLAAL--RDPEAGAVVTFVGTVRDHDEGKGVEALEYEAYPPMAEKELEEIAEEARERWGLLRVAIIHRVGRLPPG 78

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*.
gi 503243781  93 DEIVFVVAASAHRRAAFEAADYLMDRLKSEAALWKREVGPGFARWV 138
Cdd:cd00756   79 EAIVLVAVSSPHRKEAFEACEFLIDRLKHRAPIWKKEIFEGGEEWV 124
moaE PRK10678
molybdopterin synthase catalytic subunit MoaE;
30-151 2.15e-36

molybdopterin synthase catalytic subunit MoaE;


Pssm-ID: 182642  Cd Length: 150  Bit Score: 122.55  E-value: 2.15e-36
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503243781  30 GAIVTFSGRVRGETTEGAVSHLWLDWYPGMSEQSLKAIAEAAAERFDVQALLVAHRCGAVKAEDEIVFVVAASAHRRAAF 109
Cdd:PRK10678  29 GAVVTFTGKVRNHNLGDSVKALTLEHYPGMTEKALAEIVDEARSRWPLGRVTVIHRVGELWPGDEIVFVGVTSAHRSSAF 108

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|..
gi 503243781 110 EAADYLMDRLKSEAALWKREVGPGFARWVEPTATDAVDLKRW 151
Cdd:PRK10678 109 EAGQFIMDYLKTRAPFWKREATPEGDRWVEARDSDQQAAKRW 150
MoaE pfam02391
MoaE protein; This family contains the MoaE protein that is involved in biosynthesis of ...
 24-122 1.09e-33

MoaE protein; This family contains the MoaE protein that is involved in biosynthesis of molybdopterin. Molybdopterin, the universal component of the pterin molybdenum cofactors, contains a dithiolene group serving to bind Mo. Addition of the dithiolene sulfurs to a molybdopterin precursor requires the activity of the converting factor. Converting factor contains the MoaE and MoaD proteins.


Pssm-ID: 460546  Cd Length: 113  Bit Score: 114.47  E-value: 1.09e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503243781   24 AANRGAGAIVTFSGRVRGETTEGAVSHLWLDWYPGMSEQSLKAIAEAAAERFDVQALLVAHRCGAVKAEDEIVFVVAASA 103
Cdd:pfam02391  15 VSDPEAGAVVTFVGTVRDHFDGKKVTALEYEAYPPMAEKELAEIAEEARERWPLLDVAIVHRVGRLPVGEAIVLVAVSSP 94

                          90
                  ....*....|....*....
gi 503243781  104 HRRAAFEAADYLMDRLKSE 122
Cdd:pfam02391  95 HRAEAFEACEYLIDELKAR 113
 
Name Accession Description Interval E-value
MoaE COG0314
Molybdopterin synthase catalytic subunit MoaE [Coenzyme transport and metabolism]; ...
 8-145 1.10e-51

Molybdopterin synthase catalytic subunit MoaE [Coenzyme transport and metabolism]; Molybdopterin synthase catalytic subunit MoaE is part of the Pathway/BioSystem: Molybdopterin biosynthesis


Pssm-ID: 440083 [Multi-domain]  Cd Length: 143  Bit Score: 161.12  E-value: 1.10e-51
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503243781   8 LLPQALDGQALYGRFVAANRGAGAIVTFSGRVRGETTEGAVSHLWLDWYPGMSEQSLKAIAEAAAERFDVQALLVAHRCG 87
Cdd:COG0314    6 VTEEPFDLAAELAALRASDPEAGAVVTFVGTVRDHNDGRRVTALEYEAYPPMAEKELAEIAEEAAERWGLLDVAVIHRVG 85

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 503243781  88 AVKAEDEIVFVVAASAHRRAAFEAADYLMDRLKSEAALWKREVGPGFARWVEPTATDA 145
Cdd:COG0314   86 RLEPGEPIVLVAVSSAHRKEAFEACRFLIDRLKTRAPIWKKEIFEDGEEWVEARSSDD 143
MoaE cd00756
MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor ...
 13-138 3.78e-44

MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and eukaryotes. Moco contains a tricyclic pyranopterin, termed molybdopterin (MPT), which carries the cis-dithiolene group responsible for molybdenum ligation. This dithiolene group is generated by MPT synthase in the second major step in Moco biosynthesis. MPT synthase is a heterotetramer consisting of two large (MoaE) and two small (MoaD) subunits.


Pssm-ID: 238385 [Multi-domain]  Cd Length: 124  Bit Score: 141.50  E-value: 3.78e-44
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503243781  13 LDGQALYGRFvaANRGAGAIVTFSGRVRGETTEGAVSHLWLDWYPGMSEQSLKAIAEAAAERFDVQALLVAHRCGAVKAE 92
Cdd:cd00756    1 FDLAELLAAL--RDPEAGAVVTFVGTVRDHDEGKGVEALEYEAYPPMAEKELEEIAEEARERWGLLRVAIIHRVGRLPPG 78

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*.
gi 503243781  93 DEIVFVVAASAHRRAAFEAADYLMDRLKSEAALWKREVGPGFARWV 138
Cdd:cd00756   79 EAIVLVAVSSPHRKEAFEACEFLIDRLKHRAPIWKKEIFEGGEEWV 124
moaE PRK10678
molybdopterin synthase catalytic subunit MoaE;
30-151 2.15e-36

molybdopterin synthase catalytic subunit MoaE;


Pssm-ID: 182642  Cd Length: 150  Bit Score: 122.55  E-value: 2.15e-36
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503243781  30 GAIVTFSGRVRGETTEGAVSHLWLDWYPGMSEQSLKAIAEAAAERFDVQALLVAHRCGAVKAEDEIVFVVAASAHRRAAF 109
Cdd:PRK10678  29 GAVVTFTGKVRNHNLGDSVKALTLEHYPGMTEKALAEIVDEARSRWPLGRVTVIHRVGELWPGDEIVFVGVTSAHRSSAF 108

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|..
gi 503243781 110 EAADYLMDRLKSEAALWKREVGPGFARWVEPTATDAVDLKRW 151
Cdd:PRK10678 109 EAGQFIMDYLKTRAPFWKREATPEGDRWVEARDSDQQAAKRW 150
MoaE pfam02391
MoaE protein; This family contains the MoaE protein that is involved in biosynthesis of ...
 24-122 1.09e-33

MoaE protein; This family contains the MoaE protein that is involved in biosynthesis of molybdopterin. Molybdopterin, the universal component of the pterin molybdenum cofactors, contains a dithiolene group serving to bind Mo. Addition of the dithiolene sulfurs to a molybdopterin precursor requires the activity of the converting factor. Converting factor contains the MoaE and MoaD proteins.


Pssm-ID: 460546  Cd Length: 113  Bit Score: 114.47  E-value: 1.09e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503243781   24 AANRGAGAIVTFSGRVRGETTEGAVSHLWLDWYPGMSEQSLKAIAEAAAERFDVQALLVAHRCGAVKAEDEIVFVVAASA 103
Cdd:pfam02391  15 VSDPEAGAVVTFVGTVRDHFDGKKVTALEYEAYPPMAEKELAEIAEEARERWPLLDVAIVHRVGRLPVGEAIVLVAVSSP 94

                          90
                  ....*....|....*....
gi 503243781  104 HRRAAFEAADYLMDRLKSE 122
Cdd:pfam02391  95 HRAEAFEACEYLIDELKAR 113
PLN02390 PLN02390
molybdopterin synthase catalytic subunit
 28-130 4.50e-22

molybdopterin synthase catalytic subunit


Pssm-ID: 178014  Cd Length: 111  Bit Score: 84.74  E-value: 4.50e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503243781  28 GAGAIVTFSGRVRgETTEG-AVSHLWLDWYPGMSEQSLKAIAEAAAERFDVQALLVAHRCGAVKAEDEIVFVVAASAHRR 106
Cdd:PLN02390   3 QAGAIATFSGTTR-DTFEGkTVLELRYEAYVPMALRELRKICDEARSRWSLHKIAVAHRLGPVPVGETSVFVAVSSVHRA 81

                         90       100
                 ....*....|....*....|....
gi 503243781 107 AAFEAADYLMDRLKSEAALWKREV 130
Cdd:PLN02390  82 DALDACKFLIDELKASVPIWKKEV 105
PRK14493 PRK14493
putative bifunctional molybdopterin-guanine dinucleotide biosynthesis protein MobB/MoaE; ...
 29-130 4.91e-20

putative bifunctional molybdopterin-guanine dinucleotide biosynthesis protein MobB/MoaE; Provisional


Pssm-ID: 237730 [Multi-domain]  Cd Length: 274  Bit Score: 83.51  E-value: 4.91e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503243781  29 AGAIVTFSGRVRGETTEGAV--SHLWLDWYPGMSEQSLKAIAEAAAERFDVQALLVAHRCGAVKAEDEIVFVVAASAHRR 106
Cdd:PRK14493 159 AGAIATFTGRVRAKEDADDEptEYLEFEKYDGVADERMAAIREELKQRDGVFEVLLHHRTGVIEAGEDIVFVVVLAGHRQ 238

                         90       100
                 ....*....|....*....|....
gi 503243781 107 AAFEAADYLMDRLKSEAALWKREV 130
Cdd:PRK14493 239 EAFRAVSDGIDRLKDEVPIFKKEV 262
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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