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Conserved domains on  [gi|503246590|ref|WP_013481251|]
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copper resistance protein B [Asticcacaulis excentricus]

Protein Classification

copper resistance protein B( domain architecture ID 11466862)

copper resistance protein B is a P-type ATPase that acts as a resistance factor to copper ions by extruding copper when concentrations approach toxic levels

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PcoB COG3667
Uncharacterized conserved protein involved in copper resistance [Inorganic ion transport and ...
 137-401 6.14e-111

Uncharacterized conserved protein involved in copper resistance [Inorganic ion transport and metabolism];


:

Pssm-ID: 442884  Cd Length: 268  Bit Score: 326.07  E-value: 6.14e-111
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503246590 137 QDQSDMAGMDMPGPngeegipmgPPPAAPSDRVADRFfgkpemdravKQLRMEHGGATVSKMMLNLAEYQSNSGGNGYRW 216
Cdd:COG3667   23 QDMDHAAQMQGSAP---------VPDARDPDAYADGY----------PRLLAMHDEHIFGFVLVDRLEYRRGDGGDALAW 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503246590 217 SGEAWYGGDLNRFVVKSEGTGSSKDGVSDGELQALYSRPIGVYTDLQVGVRHDFAPTPTRTYLTLGTETQLPFWLENENA 296
Cdd:COG3667   84 DGQAWYGGDYNRLWLKSEGEGSSGGRLEEAEVEALYSRAISPFWDLQAGVRYDFGPGPDRTWAAFGVQGLAPYWFEVDAT 163

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503246590 297 LFLSNKGELIGRSEIYHDLRLTQRWVLQTRGEINVAAQDSHETGIGSGVSNVELGWRLRYEVKRNFGPYVGFSFDQKFGK 376
Cdd:COG3667  164 AYLSEDGDLAARLEAEYDLLLTQRLILQPRAELNLYAQDDPERGIGSGLSDVELGLRLRYEIRREFAPYVGVEWERKFGD 243

                        250       260
                 ....*....|....*....|....*
gi 503246590 377 TADFAKLAGEKSHQTSVVIGIRTFF 401
Cdd:COG3667  244 TADLARAAGEDTSETRFVAGVRFWF 268
COG1754 super family cl34356
Uncharacterized C-terminal domain of topoisomerase IA [Function unknown];
37-71 6.24e-06

Uncharacterized C-terminal domain of topoisomerase IA [Function unknown];


The actual alignment was detected with superfamily member COG1754:

Pssm-ID: 441360 [Multi-domain]  Cd Length: 892  Bit Score: 48.27  E-value: 6.24e-06
                         10        20        30
                 ....*....|....*....|....*....|....*.
gi 503246590  37 PAAKPAPKKTTAKKPAVKKT-VKRATKKKASATTPT 71
Cdd:COG1754  854 AAKKAAAKKAAAKKTAAKKAaAKKAAAKKAAAKKAA 889
 
Name Accession Description Interval E-value
PcoB COG3667
Uncharacterized conserved protein involved in copper resistance [Inorganic ion transport and ...
 137-401 6.14e-111

Uncharacterized conserved protein involved in copper resistance [Inorganic ion transport and metabolism];


Pssm-ID: 442884  Cd Length: 268  Bit Score: 326.07  E-value: 6.14e-111
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503246590 137 QDQSDMAGMDMPGPngeegipmgPPPAAPSDRVADRFfgkpemdravKQLRMEHGGATVSKMMLNLAEYQSNSGGNGYRW 216
Cdd:COG3667   23 QDMDHAAQMQGSAP---------VPDARDPDAYADGY----------PRLLAMHDEHIFGFVLVDRLEYRRGDGGDALAW 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503246590 217 SGEAWYGGDLNRFVVKSEGTGSSKDGVSDGELQALYSRPIGVYTDLQVGVRHDFAPTPTRTYLTLGTETQLPFWLENENA 296
Cdd:COG3667   84 DGQAWYGGDYNRLWLKSEGEGSSGGRLEEAEVEALYSRAISPFWDLQAGVRYDFGPGPDRTWAAFGVQGLAPYWFEVDAT 163

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503246590 297 LFLSNKGELIGRSEIYHDLRLTQRWVLQTRGEINVAAQDSHETGIGSGVSNVELGWRLRYEVKRNFGPYVGFSFDQKFGK 376
Cdd:COG3667  164 AYLSEDGDLAARLEAEYDLLLTQRLILQPRAELNLYAQDDPERGIGSGLSDVELGLRLRYEIRREFAPYVGVEWERKFGD 243

                        250       260
                 ....*....|....*....|....*
gi 503246590 377 TADFAKLAGEKSHQTSVVIGIRTFF 401
Cdd:COG3667  244 TADLARAAGEDTSETRFVAGVRFWF 268
CopB pfam05275
Copper resistance protein B precursor (CopB); This family consists of several bacterial copper ...
 194-401 2.78e-109

Copper resistance protein B precursor (CopB); This family consists of several bacterial copper resistance proteins. Copper is essential and serves as cofactor for more than 30 enzymes yet a surplus of copper is toxic and leads to radical formation and oxidation of biomolecules. Therefore, copper homeostasis is a key requisite for every organizm. CopB serves to extrude copper when it approaches toxic levels.


Pssm-ID: 428404  Cd Length: 208  Bit Score: 319.48  E-value: 2.78e-109
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503246590  194 TVSKMMLNLAEYQSNSGGNGYRWSGEAWYGGDLNRFVVKSEGTGSSKDGVSDGELQALYSRPIGVYTDLQVGVRHDFAPT 273
Cdd:pfam05275   1 IFGKVLVDRLEYRDGDGGDGLAWDAQAWYGGDYNRLWLKSEGERSFGGGLEEAELQLLYSRAISPFWDLQAGVRQDFGPG 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503246590  274 PTRTYLTLGTETQLPFWLENENALFLSNKGELIGRSEIYHDLRLTQRWVLQTRGEINVAAQDSHETGIGSGVSNVELGWR 353
Cdd:pfam05275  81 PDRTWAALGVQGLAPYWFEVDATLYVSEDGDTAARLEAEYELLLTQRLILQPRLELNLYGQDDPERGIGSGLSDLEAGLR 160

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*...
gi 503246590  354 LRYEVKRNFGPYVGFSFDQKFGKTADFAKLAGEKSHQTSVVIGIRTFF 401
Cdd:pfam05275 161 LRYEISREFAPYIGVEWERKFGDTADFARAEGESTSDTRFVAGLRFWF 208
COG1754 COG1754
Uncharacterized C-terminal domain of topoisomerase IA [Function unknown];
37-71 6.24e-06

Uncharacterized C-terminal domain of topoisomerase IA [Function unknown];


Pssm-ID: 441360 [Multi-domain]  Cd Length: 892  Bit Score: 48.27  E-value: 6.24e-06
                         10        20        30
                 ....*....|....*....|....*....|....*.
gi 503246590  37 PAAKPAPKKTTAKKPAVKKT-VKRATKKKASATTPT 71
Cdd:COG1754  854 AAKKAAAKKAAAKKTAAKKAaAKKAAAKKAAAKKAA 889
DUF6465 pfam20069
Family of unknown function (DUF6465); This family of proteins is functionally uncharacterized. ...
 37-64 1.19e-04

Family of unknown function (DUF6465); This family of proteins is functionally uncharacterized. This family of proteins is found in bacteria. Proteins in this family are typically between 117 and 173 amino acids in length. These proteins have a highly charged N-terminus.


Pssm-ID: 466279 [Multi-domain]  Cd Length: 130  Bit Score: 41.44  E-value: 1.19e-04
                          10        20
                  ....*....|....*....|....*...
gi 503246590   37 PAAKPAPKKTTAKKPAVKKTVKRATKKK 64
Cdd:pfam20069  40 AAKKAAAKKAAAKKTAAKKAKKAEVKEE 67
 
Name Accession Description Interval E-value
PcoB COG3667
Uncharacterized conserved protein involved in copper resistance [Inorganic ion transport and ...
 137-401 6.14e-111

Uncharacterized conserved protein involved in copper resistance [Inorganic ion transport and metabolism];


Pssm-ID: 442884  Cd Length: 268  Bit Score: 326.07  E-value: 6.14e-111
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503246590 137 QDQSDMAGMDMPGPngeegipmgPPPAAPSDRVADRFfgkpemdravKQLRMEHGGATVSKMMLNLAEYQSNSGGNGYRW 216
Cdd:COG3667   23 QDMDHAAQMQGSAP---------VPDARDPDAYADGY----------PRLLAMHDEHIFGFVLVDRLEYRRGDGGDALAW 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503246590 217 SGEAWYGGDLNRFVVKSEGTGSSKDGVSDGELQALYSRPIGVYTDLQVGVRHDFAPTPTRTYLTLGTETQLPFWLENENA 296
Cdd:COG3667   84 DGQAWYGGDYNRLWLKSEGEGSSGGRLEEAEVEALYSRAISPFWDLQAGVRYDFGPGPDRTWAAFGVQGLAPYWFEVDAT 163

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503246590 297 LFLSNKGELIGRSEIYHDLRLTQRWVLQTRGEINVAAQDSHETGIGSGVSNVELGWRLRYEVKRNFGPYVGFSFDQKFGK 376
Cdd:COG3667  164 AYLSEDGDLAARLEAEYDLLLTQRLILQPRAELNLYAQDDPERGIGSGLSDVELGLRLRYEIRREFAPYVGVEWERKFGD 243

                        250       260
                 ....*....|....*....|....*
gi 503246590 377 TADFAKLAGEKSHQTSVVIGIRTFF 401
Cdd:COG3667  244 TADLARAAGEDTSETRFVAGVRFWF 268
CopB pfam05275
Copper resistance protein B precursor (CopB); This family consists of several bacterial copper ...
 194-401 2.78e-109

Copper resistance protein B precursor (CopB); This family consists of several bacterial copper resistance proteins. Copper is essential and serves as cofactor for more than 30 enzymes yet a surplus of copper is toxic and leads to radical formation and oxidation of biomolecules. Therefore, copper homeostasis is a key requisite for every organizm. CopB serves to extrude copper when it approaches toxic levels.


Pssm-ID: 428404  Cd Length: 208  Bit Score: 319.48  E-value: 2.78e-109
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503246590  194 TVSKMMLNLAEYQSNSGGNGYRWSGEAWYGGDLNRFVVKSEGTGSSKDGVSDGELQALYSRPIGVYTDLQVGVRHDFAPT 273
Cdd:pfam05275   1 IFGKVLVDRLEYRDGDGGDGLAWDAQAWYGGDYNRLWLKSEGERSFGGGLEEAELQLLYSRAISPFWDLQAGVRQDFGPG 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503246590  274 PTRTYLTLGTETQLPFWLENENALFLSNKGELIGRSEIYHDLRLTQRWVLQTRGEINVAAQDSHETGIGSGVSNVELGWR 353
Cdd:pfam05275  81 PDRTWAALGVQGLAPYWFEVDATLYVSEDGDTAARLEAEYELLLTQRLILQPRLELNLYGQDDPERGIGSGLSDLEAGLR 160

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*...
gi 503246590  354 LRYEVKRNFGPYVGFSFDQKFGKTADFAKLAGEKSHQTSVVIGIRTFF 401
Cdd:pfam05275 161 LRYEISREFAPYIGVEWERKFGDTADFARAEGESTSDTRFVAGLRFWF 208
COG1754 COG1754
Uncharacterized C-terminal domain of topoisomerase IA [Function unknown];
37-71 6.24e-06

Uncharacterized C-terminal domain of topoisomerase IA [Function unknown];


Pssm-ID: 441360 [Multi-domain]  Cd Length: 892  Bit Score: 48.27  E-value: 6.24e-06
                         10        20        30
                 ....*....|....*....|....*....|....*.
gi 503246590  37 PAAKPAPKKTTAKKPAVKKT-VKRATKKKASATTPT 71
Cdd:COG1754  854 AAKKAAAKKAAAKKTAAKKAaAKKAAAKKAAAKKAA 889
COG1754 COG1754
Uncharacterized C-terminal domain of topoisomerase IA [Function unknown];
37-69 9.98e-06

Uncharacterized C-terminal domain of topoisomerase IA [Function unknown];


Pssm-ID: 441360 [Multi-domain]  Cd Length: 892  Bit Score: 47.89  E-value: 9.98e-06
                         10        20        30
                 ....*....|....*....|....*....|....
gi 503246590  37 PAAKPAPKKTTAKKPAVKKT-VKRATKKKASATT 69
Cdd:COG1754  859 AAKKAAAKKTAAKKAAAKKAaAKKAAAKKAAKKA 892
COG1754 COG1754
Uncharacterized C-terminal domain of topoisomerase IA [Function unknown];
37-71 2.05e-05

Uncharacterized C-terminal domain of topoisomerase IA [Function unknown];


Pssm-ID: 441360 [Multi-domain]  Cd Length: 892  Bit Score: 46.73  E-value: 2.05e-05
                         10        20        30
                 ....*....|....*....|....*....|....*.
gi 503246590  37 PAAKPAPKKTTAKKPAVKKT-VKRATKKKASATTPT 71
Cdd:COG1754  844 RAKGPAKKKKAAKKAAAKKAaAKKTAAKKAAAKKAA 879
COG1754 COG1754
Uncharacterized C-terminal domain of topoisomerase IA [Function unknown];
40-71 9.96e-05

Uncharacterized C-terminal domain of topoisomerase IA [Function unknown];


Pssm-ID: 441360 [Multi-domain]  Cd Length: 892  Bit Score: 44.42  E-value: 9.96e-05
                         10        20        30
                 ....*....|....*....|....*....|...
gi 503246590  40 KPAPKKTTAKKPAVKKT-VKRATKKKASATTPT 71
Cdd:COG1754  852 KKAAKKAAAKKAAAKKTaAKKAAAKKAAAKKAA 884
DUF6465 pfam20069
Family of unknown function (DUF6465); This family of proteins is functionally uncharacterized. ...
 37-64 1.19e-04

Family of unknown function (DUF6465); This family of proteins is functionally uncharacterized. This family of proteins is found in bacteria. Proteins in this family are typically between 117 and 173 amino acids in length. These proteins have a highly charged N-terminus.


Pssm-ID: 466279 [Multi-domain]  Cd Length: 130  Bit Score: 41.44  E-value: 1.19e-04
                          10        20
                  ....*....|....*....|....*...
gi 503246590   37 PAAKPAPKKTTAKKPAVKKTVKRATKKK 64
Cdd:pfam20069  40 AAKKAAAKKAAAKKTAAKKAKKAEVKEE 67
DUF6465 pfam20069
Family of unknown function (DUF6465); This family of proteins is functionally uncharacterized. ...
 37-65 1.02e-03

Family of unknown function (DUF6465); This family of proteins is functionally uncharacterized. This family of proteins is found in bacteria. Proteins in this family are typically between 117 and 173 amino acids in length. These proteins have a highly charged N-terminus.


Pssm-ID: 466279 [Multi-domain]  Cd Length: 130  Bit Score: 38.75  E-value: 1.02e-03
                          10        20
                  ....*....|....*....|....*....
gi 503246590   37 PAAKPAPKKTTAKKPAVKKTVKRATKKKA 65
Cdd:pfam20069  35 KAAKAAAKKAAAKKAAAKKTAAKKAKKAE 63
HC2 pfam07382
Histone H1-like nucleoprotein HC2; This family contains the bacterial histone H1-like ...
 32-68 7.29e-03

Histone H1-like nucleoprotein HC2; This family contains the bacterial histone H1-like nucleoprotein HC2 (approximately 200 residues long), which seems to be found mostly in Chlamydia. HC2 functions in DNA condensation, although it has been suggested that it also has other roles.


Pssm-ID: 369339 [Multi-domain]  Cd Length: 187  Bit Score: 37.45  E-value: 7.29e-03
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 503246590   32 PGMQMPAAKPAPKKTTAKKPAVKKTV-KRATKKKASAT 68
Cdd:pfam07382 104 VAKKAAAKKPAAKKAVAKKAVARKPAaKKAVAKKAAST 141
HC2 pfam07382
Histone H1-like nucleoprotein HC2; This family contains the bacterial histone H1-like ...
 37-67 8.38e-03

Histone H1-like nucleoprotein HC2; This family contains the bacterial histone H1-like nucleoprotein HC2 (approximately 200 residues long), which seems to be found mostly in Chlamydia. HC2 functions in DNA condensation, although it has been suggested that it also has other roles.


Pssm-ID: 369339 [Multi-domain]  Cd Length: 187  Bit Score: 37.07  E-value: 8.38e-03
                          10        20        30
                  ....*....|....*....|....*....|..
gi 503246590   37 PAAKPAPKKTTAKKPAVKKTV-KRATKKKASA 67
Cdd:pfam07382  74 VAKKPVAKKAVAKKATAKKVAaKKVVAKKTVA 105
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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