|
Name |
Accession |
Description |
Interval |
E-value |
| PRK01810 |
PRK01810 |
DNA polymerase IV; Validated |
6-414 |
0e+00 |
|
DNA polymerase IV; Validated
Pssm-ID: 179337 [Multi-domain] Cd Length: 407 Bit Score: 756.48 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503289092 6 ESRGRIIFHVDCNSFFASCEIARHPTLREKPVVVAGDPKERRGIVLAANYVAKQhFGIYTTMPLWEAKKRCLDLVVRPPD 85
Cdd:PRK01810 1 PKKGRVIFHVDMNSFFASVEIAYDPSLQGKPLAVAGNEKERKGIIVTCSYEARA-YGIRTTMPLWEAKRLCPQLIVRRPN 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503289092 86 FAFYREMSRRMFQWLERFSPVLERASIDEGYLDMTGRTPTVHPLAVAHQIQRGLLEQLSIPVSIGIAPNKFLAKMASEMK 165
Cdd:PRK01810 80 FDRYREASRQMFQILSEFTPLVQPVSIDEGYLDITDCYALGSPLEIAKMIQQRLLTELQLPCSIGIAPNKFLAKMASDMK 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503289092 166 KPLGITVLRKRDVPAVLWPLPVEQMHGVGDKTAKKLHALGLRTIGDIANADRVLLEKTFGVYGLRLHERANGIDPRPVDP 245
Cdd:PRK01810 160 KPLGITVLRKRDVPEMLWPLPVGEMHGIGEKTAEKLKDIGIQTIGDLAKADEHILRAKLGINGVRLQRRANGIDDRPVDP 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503289092 246 EATEKWKSVGNSTTLPRDTDDEQELRAVLRKLAESVSVRMKQKRVVSRTVQLTIRYRDFRTITRSQTEAAPLQTADDLFL 325
Cdd:PRK01810 240 EAIYQFKSVGNSTTLSHDMDEEKELLDVLRRLSKSVSKRLQKKTVVSYNVQIMIRYHDRRTITRSKTLKNPIWEKRDIFQ 319
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503289092 326 TAARLLKKHWDGRPVRLLGVAALHVFDEREEGKQLDLFHYEEDAKVEALWKTIEQLRAKFGDRALRTGAELlrgVRSVPE 405
Cdd:PRK01810 320 AASRLFKQHWNGDPVRLLGVTATDLEWKTEAVKQLDLFSFEEDAKEEPLLAVIDQINDKYGMPLLQRGSQL---LRKQEK 396
|
....*....
gi 503289092 406 KKGDVLNPK 414
Cdd:PRK01810 397 TFGTSFEKD 405
|
|
| PolY_Pol_IV_kappa |
cd03586 |
DNA Polymerase IV/Kappa; Pol IV, also known as Pol kappa, DinB, and Dpo4, is a translesion ... |
13-345 |
1.86e-153 |
|
DNA Polymerase IV/Kappa; Pol IV, also known as Pol kappa, DinB, and Dpo4, is a translesion synthesis (TLS) polymerase. Translesion synthesis is a process that allows the bypass of a variety of DNA lesions. TLS polymerases lack proofreading activity and have low fidelity and low processivity. They use damaged DNA as templates and insert nucleotides opposite the lesions. Known primarily as Pol IV in prokaryotes and Pol kappa in eukaryotes, this polymerase has a propensity for generating frameshift mutations. The eukaryotic Pol kappa differs from Pol IV and Dpo4 by an N-terminal extension of ~75 residues known as the "N-clasp" region. The structure of Pol kappa shows DNA that is almost totally encircled by Pol kappa, with the N-clasp region augmenting the interactions between DNA and the polymerase. Pol kappa is more resistant than Pol eta and Pol iota to bulky guanine adducts and is efficient at catalyzing the incorporation of dCTP. Bacterial pol IV has a higher error rate than other Y-family polymerases.
Pssm-ID: 176459 [Multi-domain] Cd Length: 334 Bit Score: 436.95 E-value: 1.86e-153
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503289092 13 FHVDCNSFFASCEIARHPTLREKPVVVAGDPkeRRGIVLAANYVAKQhFGIYTTMPLWEAKKRCLDLVVRPPDFAFYREM 92
Cdd:cd03586 1 IHIDMDAFYASVEQRDNPELKGKPVAVGGSS--DRGVVSTASYEARK-FGVRSAMPIFQAKKLCPNLIFVPPRFDKYREV 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503289092 93 SRRMFQWLERFSPVLERASIDEGYLDMTGRTPTVH-PLAVAHQIQRGLLEQLSIPVSIGIAPNKFLAKMASEMKKPLGIT 171
Cdd:cd03586 78 SRQIMEILREYTPLVEPLSIDEAYLDVTDYVRLFGsATEIAKEIRARIREETGLTASAGIAPNKFLAKIASDLNKPNGLT 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503289092 172 VLRKRDVPAVLWPLPVEQMHGVGDKTAKKLHALGLRTIGDIANADRVLLEKTFGVYGLRLHERANGIDPRPVDPEatEKW 251
Cdd:cd03586 158 VIPPEDVEEFLAPLPVRKIPGVGKVTAEKLKELGIKTIGDLAKLDVELLKKLFGKSGRRLYELARGIDNRPVEPD--RER 235
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503289092 252 KSVGNSTTLPRDTDDEQELRAVLRKLAESVSVRMKQKRVVSRTVQLTIRYRDFRTITRSQTEAAPLQTADDLFLTAARLL 331
Cdd:cd03586 236 KSIGVERTFSEDLTDPEELLEELLELAEELAERLRKRGLKGRTVTVKLKYADFSTRTRSRTLPEPTDDAEDIYELALELL 315
|
330
....*....|....
gi 503289092 332 KKHWDGRPVRLLGV 345
Cdd:cd03586 316 EELLDGRPIRLLGV 329
|
|
| DinP |
COG0389 |
Nucleotidyltransferase/DNA polymerase DinP involved in DNA repair [Replication, recombination ... |
10-347 |
2.74e-150 |
|
Nucleotidyltransferase/DNA polymerase DinP involved in DNA repair [Replication, recombination and repair];
Pssm-ID: 440158 [Multi-domain] Cd Length: 336 Bit Score: 429.18 E-value: 2.74e-150
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503289092 10 RIIFHVDCNSFFASCEIARHPTLREKPVVVAGDpkERRGIVLAANYVAKQhFGIYTTMPLWEAKKRCLDLVVRPPDFAFY 89
Cdd:COG0389 1 RRILHVDMDAFYASVEQRDRPELRGKPVAVGGD--NNRGVVAAASYEARA-FGVRSGMPLFQARRLCPDLVVLPPDFELY 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503289092 90 REMSRRMFQWLERFSPVLERASIDEGYLDMTGRTPTVH-PLAVAHQIQRGLLEQLSIPVSIGIAPNKFLAKMASEMKKPL 168
Cdd:COG0389 78 RDVSRRVMAILERYTPLVEPLSIDEAFLDVTGSARLFGsAEAIARRIRRRIRRETGLTVSVGIAPNKFLAKIASDLAKPD 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503289092 169 GITVLRKRDVPAVLWPLPVEQMHGVGDKTAKKLHALGLRTIGDIANADRVLLEKTFGVYGLRLHERANGIDPRPVDPEAT 248
Cdd:COG0389 158 GLTVIPPGEVAAFLAPLPVEKLWGVGPKTAEKLARLGIRTIGDLAALPRAELRRRFGKVGERLYRLARGIDPRPVEPRRP 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503289092 249 EkwKSVGNSTTLPRDTDDEQELRAVLRKLAESVSVRMKQKRVVSRTVQLTIRYRDFRTITRSQTEAAPLQTADDLFLTAA 328
Cdd:COG0389 238 R--KSIGVERTFGEDLTDLEELEAALRRLAERLAERLRRQGLGARTVTVKLRTSDFRTTTRSRTLPEPTDDTAELLRAAR 315
|
330 340
....*....|....*....|
gi 503289092 329 RLLKKHWD-GRPVRLLGVAA 347
Cdd:COG0389 316 ELLERIYRpGRPVRLLGVRL 335
|
|
| PRK03103 |
PRK03103 |
DNA polymerase IV; Reviewed |
10-398 |
7.94e-125 |
|
DNA polymerase IV; Reviewed
Pssm-ID: 235104 [Multi-domain] Cd Length: 409 Bit Score: 367.02 E-value: 7.94e-125
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503289092 10 RIIFHVDCNSFFASCEIARHPTLREKPVVVAGDPKERRGIVLAANYVAKQHfGIYTTMPLWEAKKRCLDLVVRPPDFAFY 89
Cdd:PRK03103 3 RVILLVDMQSFYASVEKAANPELKGRPVIVSGDPERRSGVVLAACPLAKAY-GVKTAERLWEAQQKCPDLVVVKPRMQRY 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503289092 90 REMSRRMFQWLERFSPVLERASIDEGYLDMTGrtpTVH----PLAVAHQIQRGLLEQLSIPVSIGIAPNKFLAKMASEM- 164
Cdd:PRK03103 82 IDVSLQITRILEDFTDLVEPFSIDEQFLDVTG---SQKlfgsPLEIAQKIQQRIMRETGVYARVGIGPNKLLAKMACDNf 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503289092 165 --KKPLGITVLRKRDVPAVLWPLPVEQMHGVGDKTAKKLHALGLRTIGDIANADRVLLEKTFGVYGLRLHERANGIDPRP 242
Cdd:PRK03103 159 akKNPDGLFTLDKEDVPADLWPLPVRKLFGVGSRMEKHLRRMGIRTIGQLANTPLERLKKRWGINGEVLWRTANGIDYSP 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503289092 243 VDPEATEKWKSVGNSTTLPRDTDDEQELRAVLRKLAESVSVRMKQKRVVSRTVQLTIRYRDFRTIT---RSQTEAAPLQT 319
Cdd:PRK03103 239 VTPHSLDRQKAIGHQMTLPRDYRGFEEIKVVLLELCEEVCRRARAKGYMGRTVSVSLRGADFDWPTgfsRQMTLPEPTNL 318
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 503289092 320 ADDLFLTAARLLKKHWDGRPVRLLGVAALHVfdEREEGKQLDLFhyEEDAKVEALWKTIEQLRAKFGDRALRTGAELLR 398
Cdd:PRK03103 319 AMEVYEAACKLFHRHWDGKPVRRVGVTLSNL--VSDDVWQLSLF--GDRERKRSLGYVMDDIKNRFGPTAILRASSLTE 393
|
|
| PRK02406 |
PRK02406 |
DNA polymerase IV; Validated |
16-363 |
9.06e-107 |
|
DNA polymerase IV; Validated
Pssm-ID: 235035 [Multi-domain] Cd Length: 343 Bit Score: 318.60 E-value: 9.06e-107
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503289092 16 DCnsFFASCEIARHPTLREKPVVVAGDPkERRGIVLAANYVAKQhFGIYTTMPLWEAKKRCLDLVVRPPDFAFYREMSRR 95
Cdd:PRK02406 2 DC--FYAAVEMRDNPELRGKPVAVGGSP-GRRGVISTCNYEARK-FGVRSAMPTAQALKLCPDLIFVPGRFDVYKEVSRQ 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503289092 96 MFQWLERFSPVLERASIDEGYLDMTgRTPTVHPLA--VAHQIQRGLLEQLSIPVSIGIAPNKFLAKMASEMKKPLGITVL 173
Cdd:PRK02406 78 IREIFRRYTDLIEPLSLDEAYLDVT-DNKLCIGSAtlIAQEIRQDIFEELGLTASAGVAPNKFLAKIASDWNKPNGLFVI 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503289092 174 RKRDVPAVLWPLPVEQMHGVGDKTAKKLHALGLRTIGDIANADRVLLEKTFGVYGLRLHERANGIDPRPVDPEATEkwKS 253
Cdd:PRK02406 157 TPEEVDAFLATLPVEKIPGVGKVTAEKLHALGIYTCADLQKYDLAELIRHFGKFGRRLYERARGIDERPVKPDRER--KS 234
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503289092 254 VGNSTTLPRDTDDEQELRAVLRKLAESVSVRM--KQKRVVSRTVQLTIRYRDFRTITRSQTeAAPLQTADDLFLTAARLL 331
Cdd:PRK02406 235 VGVERTFAEDLYDLEACLAELPRLAEKLERRLerAKPDKRIKTVGVKLKFADFQQTTKEHT-ADPLDKADLIELLAQALL 313
|
330 340 350
....*....|....*....|....*....|...
gi 503289092 332 KKHwDGRPVRLLGVaalHV-FDEREEGKQLDLF 363
Cdd:PRK02406 314 RRL-GGRGVRLLGV---GVtLLEPQLERQLLLD 342
|
|
| PRK02794 |
PRK02794 |
DNA polymerase IV; Provisional |
12-393 |
1.92e-102 |
|
DNA polymerase IV; Provisional
Pssm-ID: 179473 [Multi-domain] Cd Length: 419 Bit Score: 310.33 E-value: 1.92e-102
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503289092 12 IFHVDCNSFFASCEIARHPTLREKPVVVAGDpkeRRGIVLAANYVAKQHfGIYTTMPLWEAKKRCLDLVVRPPDFAFYRE 91
Cdd:PRK02794 38 IAHIDCDAFYASVEKRDNPELRDKPVIIGGG---KRGVVSTACYIARIH-GVRSAMPMFKALKLCPDAVVIKPDMEKYVR 113
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503289092 92 MSRRMFQWLERFSPVLERASIDEGYLDMTGrTPTVH---PLAVAHQIQRGLLEQLSIPVSIGIAPNKFLAKMASEMKKPL 168
Cdd:PRK02794 114 VGREVRAMMQALTPLVEPLSIDEAFLDLSG-TERLHgapPAVVLARFARRVEREIGITVSVGLSYNKFLAKIASDLDKPR 192
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503289092 169 GITVLRKRDVPAVLWPLPVEQMHGVGDKTAKKLHALGLRTIGDIANADRVLLEKTFGVYGLRLHERANGIDPRPVDPEAT 248
Cdd:PRK02794 193 GFSVIGRAEALAFLAPKPVGIIWGVGPATAARLARDGIRTIGDLQRADEADLMRRFGSMGLRLWRLARGIDDRKVSPDRE 272
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503289092 249 EkwKSVGNSTTLPRDTDDEQELRAVLRKLAESVSVRMKQKRVVSRTVQLTIRYRDFRTITRSQTEAAPLQTADDLFLTAA 328
Cdd:PRK02794 273 A--KSVSAETTFETDLSDFEDLEPILWRLSEKVSRRLKAAGLAGRTVTLKLKTADFRLRTRRRTLEDPTQLADRIFRTAR 350
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 503289092 329 RLLKKHWDGRPVRLL--GVAALHVFDEREEGKQLDlfhyEEDAKVEALWKTIEQLRAKFGDRALRTG 393
Cdd:PRK02794 351 ELLEKETDGTAFRLIgiGVSDLSPADEADPPDLLD----PQATRRAAAERAIDALRAKFGAAAVETG 413
|
|
| PolY_Pol_V_umuC |
cd01700 |
umuC subunit of DNA Polymerase V; umuC subunit of Pol V. Pol V is a bacterial translesion ... |
13-345 |
7.27e-90 |
|
umuC subunit of DNA Polymerase V; umuC subunit of Pol V. Pol V is a bacterial translesion synthesis (TLS) polymerase that consists of the heterotrimer of one umuC and two umuD subunits. Translesion synthesis is a process that allows the bypass of a variety of DNA lesions. TLS polymerases lack proofreading activity and have low fidelity and low processivity. They use damaged DNA as templates and insert nucleotides opposite the lesions. Pol V, RecA, single stranded DNA-binding protein, beta sliding clamp, and gamma clamp loading complex are responsible for inducing the SOS response in bacteria to repair UV-induced DNA damage.
Pssm-ID: 176454 [Multi-domain] Cd Length: 344 Bit Score: 275.58 E-value: 7.27e-90
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503289092 13 FHVDCNSFFASCEIARHPTLREKPVVVAGDPKerrGIVLAANYVAKQhFGIYTTMPLWEAKKRC--LDLVVRPPDFAFYR 90
Cdd:cd01700 1 ALVDCNSFYASCERVFRPLLLGRPLVVLSNND---GCVIARSPEAKA-LGIKMGSPYFKVPDLLerHGVAVFSSNYALYG 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503289092 91 EMSRRMFQWLERFSPVLERASIDEGYLDMTGRTPTVHPLAVAHQIQRGLLEQLSIPVSIGIAPNKFLAKMASEM--KKP- 167
Cdd:cd01700 77 DMSRRIMSILERFSPDVEVYSIDESFLDLTGSLRFGDLEELARKIRRRILQETGIPVTVGIGPTKTLAKLANDLakKKNp 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503289092 168 -LGITVLRKRDVP-AVLWPLPVEQMHGVGDKTAKKLHALGLRTIGDIANADRVLLEKTFGVYGLRLHERANGIDPRPVDP 245
Cdd:cd01700 157 yGGVVDLTDEEVRdKLLKILPVGDVWGIGRRTAKKLNAMGIHTAGDLAQADPDLLRKKFGVVGERLVRELNGIDCLPLEE 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503289092 246 EATEKwKSVGNSTTLPRDTDDEQELRAVLRKLAESVSVRMKQKRVVSRTVQLTIRY----RDFRTITRSQTEAAPLQTAD 321
Cdd:cd01700 237 YPPPK-KSIGSSRSFGRDVTDLDELKQALAEYAERAAEKLRRQKSVARTISVFIGTsgfsRQPKYYSATNTLPYPTNDTR 315
|
330 340
....*....|....*....|....*
gi 503289092 322 DLFLTAARLLKKHW-DGRPVRLLGV 345
Cdd:cd01700 316 EIVKAALRLLYAIYrPGYAYRKAGV 340
|
|
| PRK14133 |
PRK14133 |
DNA polymerase IV; Provisional |
10-345 |
4.98e-82 |
|
DNA polymerase IV; Provisional
Pssm-ID: 184529 [Multi-domain] Cd Length: 347 Bit Score: 255.41 E-value: 4.98e-82
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503289092 10 RIIFHVDCNSFFASCEIARHPTLREKPVVVAGdpKERRGIVLAANYVAKQhFGIYTTMPLWEAKKRCLDLVVRPPDFAFY 89
Cdd:PRK14133 3 RVIIHVDMDAFFASVEQMDNPKLKGKPVIVGG--ISERGVVSTCSYEARK-YGVHSAMPVFMAKKRCPHGIFLPVRHERY 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503289092 90 REMSRRMFQWLERFSPVLERASIDEGYLDMTGRTPtvHPLAVAHQIQRGLLEQLSIPVSIGIAPNKFLAKMASEMKKPLG 169
Cdd:PRK14133 80 KEVSKNIFKILYEVTPIVEPVSIDEAYLDITNIKE--EPIKIAKYIKKKVKKETGLTLSVGISYNKFLAKLASDWNKPDG 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503289092 170 ITVLRKRDVPAVLWPLPVEQMHGVGDKTAKKLHALGLRTIGDIANADRVLLEKTFGVYGLRLHERANGIDPRPVdpEATE 249
Cdd:PRK14133 158 IKIITEDMIPDILKPLPISKVHGIGKKSVEKLNNIGIYTIEDLLKLSREFLIEYFGKFGVEIYERIRGIDYREV--EVSR 235
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503289092 250 KWKSVGNSTTLPRDTDDEQELRAVLRKLAESVSVRMKQKRVVSRTVQLTIRYRDFRTITRSQTEAAPLQTADDLFLTAAR 329
Cdd:PRK14133 236 ERKSIGKETTLKKDTKDKEELKKYLKDFSNIISEELKKRNLYGKTVTVKIKTSDFQTHTKSKTLNDYIRDKEEIYNVACE 315
|
330
....*....|....*.
gi 503289092 330 LLKKHWDGRPVRLLGV 345
Cdd:PRK14133 316 ILEHINIKEPIRLIGL 331
|
|
| PRK03858 |
PRK03858 |
DNA polymerase IV; Validated |
12-405 |
1.14e-80 |
|
DNA polymerase IV; Validated
Pssm-ID: 179663 [Multi-domain] Cd Length: 396 Bit Score: 253.37 E-value: 1.14e-80
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503289092 12 IFHVDCNSFFASCEIARHPTLREKPVVVAGdpkerrGIVLAANYVAKqHFGIYTTMPLWEAKKRCLDLVVRPPDFAFYRE 91
Cdd:PRK03858 6 ILHADLDSFYASVEQRDDPALRGRPVIVGG------GVVLAASYEAK-AYGVRTAMGGRQARRLCPQAVVVPPRMSAYSR 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503289092 92 MSRRMFQWLERFSPVLERASIDEGYLDMTGRTPTV-HPLAVAHQIQRGLLEQLSIPVSIGIAPNKFLAKMASEMKKPLGI 170
Cdd:PRK03858 79 ASKAVFEVFRDTTPLVEGLSIDEAFLDVGGLRRISgTPVQIAARLRRRVREEVGLPITVGVARTKFLAKVASQVAKPDGL 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503289092 171 TVLRKRDVPAVLWPLPVEQMHGVGDKTAKKLHALGLRTIGDIANADRVLLEKTFG-VYGLRLHERANGIDPRPVdpEATE 249
Cdd:PRK03858 159 LVVPPDRELAFLHPLPVRRLWGVGPVTAAKLRAHGITTVGDVAELPESALVSLLGpAAGRHLHALAHNRDPRRV--ETGR 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503289092 250 KWKSVGNSTTLPRDTDDEQELRAVLRKLAESVSVRMKQKRVVSRTVQLTIRYRDFRTITRSQTEAAP-------LQTADD 322
Cdd:PRK03858 237 RRRSVGAQRALGRGPNSPAEVDAVVVALVDRVARRMRAAGRTGRTVVLRLRFDDFTRATRSHTLPRPtastatlLAAARD 316
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503289092 323 LFLTAARLLKKhwdgRPVRLLGVAALHVfdEREEGKQLDL-FHYEEDAkvEALWKTIEQLRAKFGDRALRTGAELLRGVR 401
Cdd:PRK03858 317 LVAAAAPLIAE----RGLTLVGFAVSNL--DDDGAQQLELpFGLRRPG--SALDAALDAVRDRFGNAAVTRAVLLGRDPG 388
|
....*
gi 503289092 402 -SVPE 405
Cdd:PRK03858 389 lEVPM 393
|
|
| PRK03348 |
PRK03348 |
DNA polymerase IV; Provisional |
10-363 |
1.94e-73 |
|
DNA polymerase IV; Provisional
Pssm-ID: 235118 [Multi-domain] Cd Length: 454 Bit Score: 236.75 E-value: 1.94e-73
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503289092 10 RIIFHVDCNSFFASCEIARHPTLREKPVVVAGdpKERRGIVLAANYVAKQhFGIYTTMPLWEAKKRC-LDLVVRPPDFAF 88
Cdd:PRK03348 5 RWVLHLDMDAFFASVEQLTRPTLRGRPVLVGG--LGGRGVVAGASYEARV-FGARSAMPMHQARRLVgNGAVVLPPRFVV 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503289092 89 YREMSRRMFQWLERFSPVLERASIDEGYLD---MTGRTP-TVHplAVAHQIQRGLLEQLSIPVSIGIAPNKFLAKMASEM 164
Cdd:PRK03348 82 YRAASRRVFDTLRELSPVVEQLSFDEAFVEpaeLAGASAeEVE--AFAERLRARVREETGLPASVGAGSGKQIAKIASGL 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503289092 165 KKPLGITVLRKRDVPAVLWPLPVEQMHGVGDKTAKKLHALGLRTIGDIANADRVLLEKTFG-VYGLRLHERANGIDPRPV 243
Cdd:PRK03348 160 AKPDGIRVVPPGEERELLAPLPVRRLWGIGPVTEEKLHRLGIETIGDLAALSEAEVANLLGaTVGPALHRLARGIDDRPV 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503289092 244 DPEATEkwKSVGNSTTLPRDTDDEQELRAVLRKLAESVSVRMKQKRVVSRTVQLTIRYRDFRTITRSQTEAAPLQTADDL 323
Cdd:PRK03348 240 AERAEA--KQISAESTFAVDLTTRAQLREAIERIAEHAHRRLLKDGRGARTVTVKLRKSDFSTLTRSATLPYATDDAAVL 317
|
330 340 350 360
....*....|....*....|....*....|....*....|
gi 503289092 324 FLTAARLLKKHWDGRPVRLLGVAalhvFDEREEGKQLDLF 363
Cdd:PRK03348 318 AATARRLLLDPDEIGPIRLVGVG----FSGLSDVRQESLF 353
|
|
| PolY |
cd00424 |
Y-family of DNA polymerases; Y-family DNA polymerases are a specialized subset of polymerases ... |
13-345 |
3.44e-73 |
|
Y-family of DNA polymerases; Y-family DNA polymerases are a specialized subset of polymerases that facilitate translesion synthesis (TLS), a process that allows the bypass of a variety of DNA lesions. Unlike replicative polymerases, TLS polymerases lack proofreading activity and have low fidelity and low processivity. They use damaged DNA as templates and insert nucleotides opposite the lesions. The active sites of TLS polymerases are large and flexible to allow the accomodation of distorted bases. Most TLS polymerases are members of the Y-family, including Pol eta, Pol kappa/IV, Pol iota, Rev1, and Pol V, which is found exclusively in bacteria. In eukaryotes, the B-family polymerase Pol zeta also functions as a TLS polymerase. Expression of Y-family polymerases is often induced by DNA damage and is believed to be highly regulated. TLS is likely induced by the monoubiquitination of the replication clamp PCNA, which provides a scaffold for TLS polymerases to bind in order to access the lesion. Because of their high error rates, TLS polymerases are potential targets for cancer treatment and prevention.
Pssm-ID: 176453 [Multi-domain] Cd Length: 343 Bit Score: 232.64 E-value: 3.44e-73
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503289092 13 FHVDCNSFFASCEIARHPTLREKPVVVAGDPKERRGIVlAANYVAKQhFGIYTTMPLWEAKKRCLDLVVRPPDFAFYREM 92
Cdd:cd00424 1 LHIDFDNFFASVEQLARPELKGRPVVVVPFNSDSTCVI-ACSYEARK-YGVKRGMPVREARKMCPNLILVPARLDLYRRL 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503289092 93 SRRMFQWLERFSPVLERASIDEGYLDMTG--RTPTvHPLAVAHQIQRGLLEQL-SIPVSIGIAPNKFLAKMASEMKKPLG 169
Cdd:cd00424 79 SERLLSELEEVAPLVEVASIDELFLDLTGsaRLLG-LGSEVALRIKRHIAEQLgGITASIGIASNKLLAKLAAKYAKPDG 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503289092 170 ITVLRKRDVPAVLWPLPVEQMHGVGDKTAKKLHALGLRTIGDIANADRV-LLEKTFGVYGLRLHERANGIDPRPVDPeAT 248
Cdd:cd00424 158 LTILDPEDLPGFLSKLPLTDLPGIGAVTAKRLEAVGINPIGDLLAASPDaLLALWGGVSGERLWYALRGIDDEPLSP-PR 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503289092 249 EKwKSVGNSTTLPRDTDDEQELRAVLRKLAESVSVRMKQKRVVSRTVQLTIRYRDFRTITRSQTEA----APLQTADDLF 324
Cdd:cd00424 237 PR-KSFSHERVLPRDSRNAEDARPLLRLLLEKLARRLRRDGRGATRLRLWLRTVDGRWSGHADIPSrsapRPISTEDGEL 315
|
330 340
....*....|....*....|....*
gi 503289092 325 LTAAR-LLKKHWD---GRPVRLLGV 345
Cdd:cd00424 316 LHALDkLWRALLDdkgPRRLRRLGV 340
|
|
| PRK03352 |
PRK03352 |
DNA polymerase IV; Validated |
7-347 |
5.31e-70 |
|
DNA polymerase IV; Validated
Pssm-ID: 179564 [Multi-domain] Cd Length: 346 Bit Score: 224.52 E-value: 5.31e-70
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503289092 7 SRGRIIFHVDCNSFFASCEIARHPTLREKPVVV--AGDPKERRGIVLAANYVAKQhFGIYTTMPLWEAKKRCLDLVVRPP 84
Cdd:PRK03352 2 AMPRWVLHVDLDQFIAAVELLRRPELAGLPVIVggNGDPTEPRKVVTCASYEARA-FGVRAGMPLRTAARRCPDAVFLPS 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503289092 85 DFAFYREMSRRMFQWLERFSPVLERASIDEGYLDMTgrtpTVHPLAVAHQIQRGLLEQLSIPVSIGIAPNKFLAKMASEM 164
Cdd:PRK03352 81 DPAAYDAASEEVMATLRDLGVPVEVWGWDEAFLGVD----TDDPEALAEEIRAAVLERTGLSCSVGIGDNKLRAKIATGF 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503289092 165 KKPLGITVLRKRDVPAVLWPLPVEQMHGVGDKTAKKLHALGLRTIGDIANADRVLLEKTFG-VYGLRLHERANGIDPRPV 243
Cdd:PRK03352 157 AKPAGVFRLTDANWMAVMGDRPTDALWGVGPKTAKRLAALGITTVADLAAADPAELAATFGpTTGPWLLLLARGGGDTEV 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503289092 244 DPEAtekWKSVGNS--TTLPRDTDDEQELRAVLRKLAESVSVRM-KQKRVVSRtVQLTIRYRDFRTITRSQTEAAPLQTA 320
Cdd:PRK03352 237 SAEP---WVPRSRSreVTFPQDLTDRAEVESAVRELARRVLDEVvAEGRPVTR-VAVKVRTATFYTRTKIRKLPEPTTDP 312
|
330 340
....*....|....*....|....*..
gi 503289092 321 DDLFLTAARLLKKHWDGRPVRLLGVAA 347
Cdd:PRK03352 313 DVIEAAALDVLDRFELDRPVRLLGVRL 339
|
|
| IMS |
pfam00817 |
impB/mucB/samB family; These proteins are involved in UV protection (Swiss). |
15-163 |
1.39e-57 |
|
impB/mucB/samB family; These proteins are involved in UV protection (Swiss).
Pssm-ID: 425885 [Multi-domain] Cd Length: 148 Bit Score: 185.47 E-value: 1.39e-57
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503289092 15 VDCNSFFASCEIARHPTLREKPVVVAGDPkeRRGIVLAANYVAKQhFGIYTTMPLWEAKKRCLDLVVRPPDFAFYREMSR 94
Cdd:pfam00817 1 IDMDAFFASVELLRDPELKGKPVAVGGGN--GRGIVAAASYEARK-YGVRSGMPVFEAKKLCPNLIVVPPDLELYRRASR 77
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 503289092 95 RMFQWLERFSPVL-ERASIDEGYLDMTGrtpTVH----PLAVAHQIQRGLLEQLSIPVSIGIAPNKFLAKMASE 163
Cdd:pfam00817 78 KIFEILRRFSTPKvEQASIDEAFLDLTG---LEKlfgaEEALAKRLRREIAEETGLTCSIGIAPNKLLAKLASD 148
|
|
| PolY_Rev1 |
cd01701 |
DNA polymerase Rev1; Rev1 is a translesion synthesis (TLS) polymerase found in eukaryotes. ... |
7-303 |
4.04e-53 |
|
DNA polymerase Rev1; Rev1 is a translesion synthesis (TLS) polymerase found in eukaryotes. Translesion synthesis is a process that allows the bypass of a variety of DNA lesions. TLS polymerases lack proofreading activity and have low fidelity and low processivity. They use damaged DNA as templates and insert nucleotides opposite the lesions. Rev1 has both structural and enzymatic roles. Structurally, it is believed to interact with other nonclassical polymerases and replication machinery to act as a scaffold. Enzymatically, it catalyzes the specific insertion of dCMP opposite abasic sites. Rev1 interacts with the Rev7 subunit of the B-family TLS polymerase Pol zeta (Rev3/Rev7). Rev1 is known to actively promote the introduction of mutations, potentially making it a significant target for cancer treatment.
Pssm-ID: 176455 [Multi-domain] Cd Length: 404 Bit Score: 182.13 E-value: 4.04e-53
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503289092 7 SRGRIIFHVDCNSFFASCEIARHPTLREKPVVVAGDpKERRGIVLAANYVAKQhFGIYTTMPLWEAKKRCLDLVVRPPDF 86
Cdd:cd01701 44 DLQRIIMHVDFDCFFVSVSIRNRPDLKGKPVAVCHG-KGPNSEIASCNYEARS-YGIKNGMWVGQAKKLCPQLVTLPYDF 121
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503289092 87 AFYREMSRRMFQWLERFSPVLERASIDEGYLDMTG--RTPTVHPLAVAHQIQRGLLEQLSIPVSIGIAPNKFLAKMASEM 164
Cdd:cd01701 122 EAYEEVSLTFYEILASYTDNIEAVSCDEALIDITSllEETYELPEELAEAIRNEIRETTGCSASVGIGPNILLARLATRK 201
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503289092 165 KKPLGITVLRKRDVPAVLWPLPVEQMHGVGDKTAKKLHALGLRTIGDIANADRVL--LEKTFGV-YGLRLHERANGIDPR 241
Cdd:cd01701 202 AKPDGQYHLSAEKVEEFLSQLKVGDLPGVGSSLAEKLVKLFGDTCGGLELRSKTKekLQKVLGPkTGEKLYDYCRGIDDR 281
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 503289092 242 PVdpEATEKWKSVGNSTTLPRDTDDEQELRAVLRKLAESVSVRMKQKRVVSRTVQLTIRYRD 303
Cdd:cd01701 282 PV--TGEKERKSVSAEINYGIRFTNVDDVEQFLQRLSEELSKRLEESNVTGRQITLKLMKRA 341
|
|
| PRK01216 |
PRK01216 |
DNA polymerase IV; Validated |
11-363 |
5.54e-45 |
|
DNA polymerase IV; Validated
Pssm-ID: 179251 [Multi-domain] Cd Length: 351 Bit Score: 159.18 E-value: 5.54e-45
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503289092 11 IIFHVDCNSFFASCEIARHPTLREKPVVVA--GDPKERRGIVLAANYVAKQhFGIYTTMPLWEAKKRCLDLVVRPPDFAF 88
Cdd:PRK01216 2 IILFVDFDYFFAQVEEVLNPSLKGKPVVVCvySGRFEDSGAVATANYEARK-LGIKAGMPIVEAKKILPNAVYLPMRKEV 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503289092 89 YREMSRRMFQWLERFSPVLERASIDEGYLDMTGRTPTVH-PLAVAHQIQRGLLEQLSIPVSIGIAPNKFLAKMASEMKKP 167
Cdd:PRK01216 81 YQQVSNRIMKLLREYSEKIEIASIDEAYLDISDKVKNYQdAYNLGLEIKNKILEKEKITVTVGISKNKVFAKIAADMAKP 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503289092 168 LGITVLRKRDVPAVLWPLPVEQMHGVGDKTAKKLHALGLRTIGDIANADRVLLEKTFG-VYGLRLHERANGIDPRPVDPE 246
Cdd:PRK01216 161 NGIKVIDDEEVKRFINELDIADIPGIGDITAEKLKKLGVNKLVDTLRIEFDELKGIIGeAKAKYLFSLARNEYNEPVRAR 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503289092 247 ATekwKSVGNSTTLPRDTDDEQELRAVLRKLAESVSVRM----KQKRVVSRTVQLTIryrdfrtITRSQTEAAPLqTADD 322
Cdd:PRK01216 241 VR---KSIGRYVTLPRNTRDLEEIKPYLKRAIEEAYYKLdgipKAIHVVAIMEDLDI-------VSRGRTFTHGI-SKET 309
|
330 340 350 360
....*....|....*....|....*....|....*....|...
gi 503289092 323 LFLTAARLLKK--HWDGRPVRLLGVAalhvFDEREEGKQLDLF 363
Cdd:PRK01216 310 AYREAVRLLQKilEEDERKIRRIGVR----FSKIIEAIGLDKF 348
|
|
| PolY_Pol_eta |
cd01702 |
DNA Polymerase eta; Pol eta, also called Rad30A, is a translesion synthesis (TLS) polymerase. ... |
14-333 |
2.77e-41 |
|
DNA Polymerase eta; Pol eta, also called Rad30A, is a translesion synthesis (TLS) polymerase. Translesion synthesis is a process that allows the bypass of a variety of DNA lesions. TLS polymerases lack proofreading activity and have low fidelity and low processivity. They use damaged DNA as templates and insert nucleotides opposite the lesions. Unlike other Y-family members, Pol eta can efficiently and accurately replicate DNA past UV-induced lesions. Its activity is initiated by two simultaneous interactions: the PIP box in pol eta interacting with PCNA, and the UBZ (ubiquitin-binding zinc finger) in pol eta interacting with monoubiquitin attached to PCNA. Pol eta is more efficient in copying damaged DNA than undamaged DNA and seems to recognize when a lesion has been passed, facilitating a lesion-dependent dissociation from the DNA.
Pssm-ID: 176456 [Multi-domain] Cd Length: 359 Bit Score: 149.39 E-value: 2.77e-41
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503289092 14 HVDCNSFFASCEIARHPTLREKPVVVAgdpkeRRGIVLAANYVAKQhFGIYTTMPLWEAKKRCLDLV-VRPPDFAF---- 88
Cdd:cd01702 2 HIDMDAFFAQVEQVRLGLLRNDPVAVV-----QWNSIIAVSYAARA-FGVTRFMTIDEAKKKCPDLIlAHVATYKKgede 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503289092 89 ------------------YREMSRRMFQWLERFSPVLERASIDEGYLDMTGRtptvhplaVAHQIQRGLLEQLSIPVSIG 150
Cdd:cd01702 76 adyhenpsparhkvsldpYRRASRKILNILKRFGDVVEKASIDEAYLDLGSR--------IVEEIRQQVYDELGYTCSAG 147
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503289092 151 IAPNKFLAKMASEMKKPLGITVLRKRDVPAVLWPLPVEQMHGVGDKTAKKLHA-LGLRTIGDIAN---ADRVLLEKTFGV 226
Cdd:cd01702 148 IAHNKMLAKLASGMNKPNAQTILRNDAVASFLSSLPITSIRGLGGKLGEEIIDlLGLPTEGDVAGfrsSESDLQEHFGEK 227
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503289092 227 YGLRLHERANGIDPRPVDPEATEkwKSVGNSTTLPRDT-DDEQELRAVLRKLAESVSVRM----KQKRVVSRTVQLTIRy 301
Cdd:cd01702 228 LGEWLYNLLRGIDHEPVKPRPLP--KSMGSSKNFPGKTaLSTEDVQHWLLVLASELNSRLeddrYENNRRPKTLVLSLR- 304
|
330 340 350
....*....|....*....|....*....|..
gi 503289092 302 RDFRTITRSQTEAAPLQTADDLFLTAARLLKK 333
Cdd:cd01702 305 QRGDGVRRSRSCALPRYDAQKIVKDAFKLIKA 336
|
|
| PolY_Pol_iota |
cd01703 |
DNA Polymerase iota; Pol iota, also called Rad30B, is a translesion synthesis (TLS) polymerase. ... |
14-317 |
1.60e-31 |
|
DNA Polymerase iota; Pol iota, also called Rad30B, is a translesion synthesis (TLS) polymerase. Translesion synthesis is a process that allows the bypass of a variety of DNA lesions. TLS polymerases lack proofreading activity and have low fidelity and low processivity. They use damaged DNA as templates and insert nucleotides opposite the lesions. Pol iota is thought to be one of the least efficient polymerases, particularly when opposite pyrimidines; it can incorporate the correct nucleotide opposite a purine much more efficiently than opposite a pyrimidine, and prefers to insert guanosine instead of adenosine opposite thymidine. Pol iota is believed to use Hoogsteen rather than Watson-Crick base pairing, which may explain the varying efficiency for different template nucleotides.
Pssm-ID: 176457 [Multi-domain] Cd Length: 379 Bit Score: 123.35 E-value: 1.60e-31
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503289092 14 HVDCNSFFASCEIARHPTLREKPVVVagdpkERRGIVLAANYVAKQhFGIYTTMPLWEAKKRCLDLV-VRPPDFAFYREM 92
Cdd:cd01703 2 HLDLDCFYAQVEEIRDPSLKSKPLGI-----QQKYIVVTCNYEARR-LGVKKLMSIKDAKEICPDLVlVNGEDLTPFRDM 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503289092 93 SRRMFQWLERFSP--VLERASIDEGYLDMTGRTptvhpLAVAHQI----QRGLLEQLSIPVSIGIAPNKFLAKMASEMKK 166
Cdd:cd01703 76 SKKVYRLLRSYSWndRVERLGFDENFMDVTEMR-----LLVASHIayemRERIENELGLTCCAGIASNKLLAKLVGSVNK 150
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503289092 167 PLGITVL---RKRDVPAVLWPLPVEQMHGVGDKTAKKLHALGL----------RTIGDIANADRVLLEKTFGVYGL---- 229
Cdd:cd01703 151 PNQQTTLlppSCADLMDFMDLHDLRKIPGIGYKTAAKLEAHGIssvrdlqefsNRNRQTVGAAPSLLELLLMVKEFgegi 230
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503289092 230 --RLHERANGIDPRPVDPeATEKWKSVGNSTTLPR-DTDDEQELRAVLRKLAESVSVRMKQK--------RVVSRTVQLT 298
Cdd:cd01703 231 gqRIWKLLFGRDTSPVKP-ASDFPQQISIEDSYKKcSLEEIREARNKIEELLASLLERMKQDlqevkagdGRRPHTLRLT 309
|
330 340
....*....|....*....|
gi 503289092 299 IR-YRDFRTITRSQTEAAPL 317
Cdd:cd01703 310 LRrYTSTKKHYNRESKQAPI 329
|
|
| umuC |
PRK03609 |
translesion error-prone DNA polymerase V subunit UmuC; |
14-386 |
2.48e-30 |
|
translesion error-prone DNA polymerase V subunit UmuC;
Pssm-ID: 179607 [Multi-domain] Cd Length: 422 Bit Score: 121.03 E-value: 2.48e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503289092 14 HVDCNSFFASCEIARHPTLREKPVVVAGDpkeRRGIVLAANYVAKQhFGIYTTMPLWEAK--KRCLDLVVRPPDFAFYRE 91
Cdd:PRK03609 4 LCDVNSFYASCETVFRPDLRGKPVVVLSN---NDGCVIARSAEAKA-LGIKMGDPWFKQKdlFRRCGVVCFSSNYELYAD 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503289092 92 MSRRMFQWLERFSPVLERASIDEGYLDMTGRTPTVHPLAVAHQIQRGLLEQLSIPVSIGIAPNKFLAKMASEMKKPL--- 168
Cdd:PRK03609 80 MSNRVMSTLEELSPRVEIYSIDEAFCDLTGVRNCRDLTDFGREIRATVLQRTHLTVGVGIAQTKTLAKLANHAAKKWqrq 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503289092 169 --GITVL----RKRDVPAVLwplPVEQMHGVGDKTAKKLHALGLRTIGDIANADRVLLEKTFGVYGLRLHERANGIDPRP 242
Cdd:PRK03609 160 tgGVVDLsnleRQRKLLSLQ---PVEEVWGVGRRISKKLNAMGIKTALDLADTNIRFIRKHFNVVLERTVRELRGEPCLS 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503289092 243 VDPEATEKWKSVGNSTTLPRDTDDEqELRAVLRKLAESVSVRMKQKRVVSRTVQLTIRYRDFRT----ITRSQTEAAPLQ 318
Cdd:PRK03609 237 LEEFAPTKQEIVCSRSFGERITDYE-SMRQAICSYAARAAEKLRGEHQYCRFISTFVKTSPFALnepyYGNSASVKLLTP 315
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503289092 319 TAD--DLFLTAARLLKKHW-DGRP-----VRL-----LGVAALHVFDEReegkqldlfhyEEDAKVEALWKTIEQLRAKF 385
Cdd:PRK03609 316 TQDsrDIIAAATRALDAIWrDGHRyqkagVMLgdffsQGVAQLNLFDDN-----------APRPGSEQLMKVLDTLNAKS 384
|
.
gi 503289092 386 G 386
Cdd:PRK03609 385 G 385
|
|
| IMS_C |
pfam11799 |
impB/mucB/samB family C-terminal domain; These proteins are involved in UV protection (Swiss). |
252-353 |
3.42e-29 |
|
impB/mucB/samB family C-terminal domain; These proteins are involved in UV protection (Swiss).
Pssm-ID: 463354 [Multi-domain] Cd Length: 104 Bit Score: 109.57 E-value: 3.42e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503289092 252 KSVGNSTTLPRDTDDEQELRAVLRKLAESVSVRMKQKRVVSRTVQLTIRYRDFRTITRSQTEAAPLQTADDLFLTAARLL 331
Cdd:pfam11799 2 KSIGAERTFGRDLTDLEELREALLELAEELAERLRRQGLVARTVTVKIRYSDFRTITRSVTLPSPTDDTDEIYRAALRLL 81
|
90 100
....*....|....*....|..
gi 503289092 332 KKHWDGRPVRLLGVAALHVFDE 353
Cdd:pfam11799 82 RRLYRGRPVRLLGVSLSNLVPE 103
|
|
| PolY_like |
cd03468 |
DNA Polymerase Y-family; Y-family DNA polymerases are a specialized subset of polymerases that ... |
28-349 |
7.15e-26 |
|
DNA Polymerase Y-family; Y-family DNA polymerases are a specialized subset of polymerases that facilitate translesion synthesis (TLS), a process that allows the bypass of a variety of DNA lesions. Unlike replicative polymerases, TLS polymerases lack proofreading activity and have low fidelity and low processivity. They use damaged DNA as templates and insert nucleotides opposite the lesions. The active sites of TLS polymerases are large and flexible to allow the accomodation of distorted bases. Expression of Y-family polymerases is often induced by DNA damage and is believed to be highly regulated. TLS is likely induced by the monoubiquitination of the replication clamp PCNA, which provides a scaffold for TLS polymerases to bind in order to access the lesion. Because of their high error rates, TLS polymerases are potential targets for cancer treatment and prevention.
Pssm-ID: 176458 [Multi-domain] Cd Length: 335 Bit Score: 107.08 E-value: 7.15e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503289092 28 RHPTLREKPVVVAGDPKerRGIVLAANYVAKQHfGIYTTMPLWEAKKRCLDLVVRPPDFAFYREMSRRMFQWLERFSPVL 107
Cdd:cd03468 16 NRPADDEAPLAVVERKK--AGRILACNAAARAA-GVRPGMPLAEALALCPNLQVVEYDPEADARALQELALWLLRFTPLV 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503289092 108 ERASIDEGYLDMTGRTpTVHPLAVAHQIQ-RGLLEQLSIPVSIGIAPNKFLAKMASEMKKPLGI---TVLRKRDVPAVlw 183
Cdd:cd03468 93 ALDGPDGLLLDVTGCL-HLFGGEDALAASlRAALATLGLSARAGIADTPGAAWLLARAGGGRGVlrrEALAAALVLLA-- 169
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503289092 184 PLPVEQMhGVGDKTAKKLHALGLRTIGDIANADRVLLEKTFGVYGLRLHERANGIDPRPVDPEATEKWKSVGNSTTLPRD 263
Cdd:cd03468 170 PLPVAAL-RLPPETVELLARLGLRTLGDLAALPRAELARRFGLALLLRLDQAYGRDPEPLLFSPPPPAFDFRLELQLEEP 248
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503289092 264 TddEQELRAVLRKLAESVSVRMKQKRVVSRTVQLTIRYRDFRTITRSQTEAAPLQTADDLFLTAARLLKK---HWDGRPV 340
Cdd:cd03468 249 I--ARGLLFPLRRLLEQLCAFLALRGLGARRLSLTLFREDGRVTRVLVGLARPSRDDLPLLRLLRERLERlalPRGIAPV 326
|
....*....
gi 503289092 341 RLLGVAALH 349
Cdd:cd03468 327 RLLALTAEP 335
|
|
| PTZ00205 |
PTZ00205 |
DNA polymerase kappa; Provisional |
1-365 |
3.53e-25 |
|
DNA polymerase kappa; Provisional
Pssm-ID: 140232 [Multi-domain] Cd Length: 571 Bit Score: 107.80 E-value: 3.53e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503289092 1 MSTERESRGRI--IFHVDCNSFFASCEIARHPTLREKPVVVAgdpkeRRGIVLAANYVAKQHfGIYTTMPLWEAKKRCLD 78
Cdd:PTZ00205 122 IEQELEATRRLgtYIHLDMDMFYAAVEIKKHPEYAAIPLAIG-----TMTMLQTANYVARGR-GIRQGMPGFLALKICPN 195
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503289092 79 LVVRPPDFAFYREMSRRMFQWLERFSPVLERASIDE------GYLDMTGRTPTVHPlaVAHQIQRGLLEQLSIPVSIGIA 152
Cdd:PTZ00205 196 LLILPPDFDAYNEESNTVRRIVAEYDPNYISFGLDEltlevsAYIERFEGTKTAED--VASELRVRVFGETKLTASAGIG 273
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503289092 153 PNKFLAKMASEMKKPLG---ITVLRKRDVPAVLWPLPVEQMHGVGDKTAKKLHALGLRTIGDIANAD------------R 217
Cdd:PTZ00205 274 PTAALAKIASNINKPNGqhdLNLHTRGDVMTYVRDLGLRSVPGVGKVTEALLKGLGITTLSDIYNRRvelcyilhnnlfR 353
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503289092 218 VLLEKTFGVygLRLHERANGIDPRPVDPEATEKWKSVGNSTTLpRDTDDEQELRAVLRKLAESVSVRMKQKRVVSRTVQL 297
Cdd:PTZ00205 354 FLLGASIGI--MQWPDAATAANTENCEGATGGQRKAISSERSF-TTPRTKEGLQEMVDTVFNGAYEEMRKSELMCRQISL 430
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503289092 298 TIRYRDFR------TITRSQTEAAPLQTA-DDLFLTAArllKKHWDgrpVRLLGVAALHVFD------EREEGKQLDLFH 364
Cdd:PTZ00205 431 TIRWASYRyqqytkSLIQYSDDSATLRRAvDGLLLPHA---AKYSE---MCLLGVRFLDLISakdfhmKRKGGNQLSISQ 504
|
.
gi 503289092 365 Y 365
Cdd:PTZ00205 505 F 505
|
|
| IMS_HHH |
pfam11798 |
IMS family HHH motif; These proteins are involved in UV protection, eg. |
177-206 |
7.21e-07 |
|
IMS family HHH motif; These proteins are involved in UV protection, eg.
Pssm-ID: 432081 [Multi-domain] Cd Length: 32 Bit Score: 45.08 E-value: 7.21e-07
10 20 30
....*....|....*....|....*....|
gi 503289092 177 DVPAVLWPLPVEQMHGVGDKTAKKLHALGL 206
Cdd:pfam11798 3 DVPEFLWPLPISKIPGIGKKLAEKLKALGI 32
|
|
| NT_POLXc |
cd00141 |
Nucleotidyltransferase (NT) domain of family X DNA Polymerases; X family polymerases fill in ... |
175-249 |
9.74e-04 |
|
Nucleotidyltransferase (NT) domain of family X DNA Polymerases; X family polymerases fill in short gaps during DNA repair. They are relatively inaccurate enzymes and play roles in base excision repair, in non-homologous end joining (NHEJ) which acts mainly to repair damage due to ionizing radiation, and in V(D)J recombination. This family includes eukaryotic Pol beta, Pol lambda, Pol mu, and terminal deoxyribonucleotidyl transferase (TdT). Pol beta and Pol lambda are primarily DNA template-dependent polymerases. TdT is a DNA template-independent polymerase. Pol mu has both template dependent and template independent activities. This subgroup belongs to the Pol beta-like NT superfamily. In the majority of enzymes in this superfamily, two carboxylates, Dx[D/E], together with a third more distal carboxylate, coordinate two divalent metal cations involved in a two-metal ion mechanism of nucleotide addition. These three carboxylate residues are fairly well conserved in this family.
Pssm-ID: 143386 [Multi-domain] Cd Length: 307 Bit Score: 41.03 E-value: 9.74e-04
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 503289092 175 KRDVPAVLwpLPVEQMHGVGDKTAKKLHALGLRTIGDIANADRVLLEKTFgVYGLRLHERANGIDPRpvdPEATE 249
Cdd:cd00141 77 REDVPPGL--LLLLRVPGVGPKTARKLYELGIRTLEDLRKAAGAKLEQNI-LIGLEYYEDFQQRIPR---EEALA 145
|
|
| DNA_pol_lambd_f |
pfam10391 |
Fingers domain of DNA polymerase lambda; DNA polymerases catalyze the addition of dNMPs onto ... |
191-220 |
1.10e-03 |
|
Fingers domain of DNA polymerase lambda; DNA polymerases catalyze the addition of dNMPs onto the 3-prime ends of DNA chains. There is a general polymerase fold consisting of three subdomains that have been likened to the fingers, palm, and thumb of a right hand. DNA_pol_lambd_f is the central three-helical region of DNA polymerase lambda referred to as the F and G helices of the fingers domain. Contacts with DNA involve this conserved helix-hairpin-helix motif in the fingers region which interacts with the primer strand. This motif is common to several DNA binding proteins and confers a sequence-independent interaction with the DNA backbone.
Pssm-ID: 463069 [Multi-domain] Cd Length: 51 Bit Score: 36.66 E-value: 1.10e-03
10 20 30
....*....|....*....|....*....|
gi 503289092 191 HGVGDKTAKKLHALGLRTIGDIANADRVLL 220
Cdd:pfam10391 7 YGVGPTTARKWYAQGYRTLDDLREKKTAKL 36
|
|
| RecG |
COG1200 |
RecG-like helicase [Replication, recombination and repair]; |
186-211 |
1.16e-03 |
|
RecG-like helicase [Replication, recombination and repair];
Pssm-ID: 440813 [Multi-domain] Cd Length: 684 Bit Score: 41.19 E-value: 1.16e-03
10 20
....*....|....*....|....*.
gi 503289092 186 PVEQMHGVGDKTAKKLHALGLRTIGD 211
Cdd:COG1200 7 PLTYLKGVGPKRAKLLAKLGIRTVGD 32
|
|
| |
