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Conserved domains on  [gi|503302525|ref|WP_013537186|]
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type III pantothenate kinase [Thermovibrio ammonificans]

Protein Classification

CoaX family protein( domain architecture ID 10003942)

CoaX family protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
CoaX COG1521
Pantothenate kinase type III [Coenzyme transport and metabolism];
8-233 7.34e-63

Pantothenate kinase type III [Coenzyme transport and metabolism];


:

Pssm-ID: 441130 [Multi-domain]  Cd Length: 250  Bit Score: 196.92  E-value: 7.34e-63
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503302525   8 LVVLDVGNTAVKAALFEGGKLFSLFTVPTARA-SEELPLQLKNL------SGTPLAYASVVPEVSRLIDKLFPQSFS--- 77
Cdd:COG1521    2 LLAIDIGNTRIKWGLFDGGELLASWRLATDRRtADELAELLRQLlaallpDIEGVIISSVVPPLTEALEELLRKYFGvpp 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503302525  78 --VSRAQKLPINVNYG--SKMGADRLAAMSALHHF--ESYVVVSCGTATVIDAV-KEKEFVGGYILPGLYTMAEALREKT 150
Cdd:COG1521   82 lvVGPGVKTGLKNAYDnpEELGADRIANAVAARELygGPLLVVDFGTATTFDVVdADGEYLGGAIAPGLGLSLEALHQRT 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503302525 151 ALLPEVKEFKTLK-PGRSTRECISAGILAATVGAVKAVVEHIGIE---PNRVFLTGGAAKDVGRVTG--WRLVEGLVLRG 224
Cdd:COG1521  162 AKLPLVELEKPPSvIGKNTVEAIQSGVVYGYAGLIEGLIERIKEElgeDPKVIATGGDAPLLAPELKtiDIVDPDLVLEG 241


                 ....*....
gi 503302525 225 IVTLYLLNK 233
Cdd:COG1521  242 LRLIYERNK 250
 
Name Accession Description Interval E-value
CoaX COG1521
Pantothenate kinase type III [Coenzyme transport and metabolism];
8-233 7.34e-63

Pantothenate kinase type III [Coenzyme transport and metabolism];


Pssm-ID: 441130 [Multi-domain]  Cd Length: 250  Bit Score: 196.92  E-value: 7.34e-63
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503302525   8 LVVLDVGNTAVKAALFEGGKLFSLFTVPTARA-SEELPLQLKNL------SGTPLAYASVVPEVSRLIDKLFPQSFS--- 77
Cdd:COG1521    2 LLAIDIGNTRIKWGLFDGGELLASWRLATDRRtADELAELLRQLlaallpDIEGVIISSVVPPLTEALEELLRKYFGvpp 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503302525  78 --VSRAQKLPINVNYG--SKMGADRLAAMSALHHF--ESYVVVSCGTATVIDAV-KEKEFVGGYILPGLYTMAEALREKT 150
Cdd:COG1521   82 lvVGPGVKTGLKNAYDnpEELGADRIANAVAARELygGPLLVVDFGTATTFDVVdADGEYLGGAIAPGLGLSLEALHQRT 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503302525 151 ALLPEVKEFKTLK-PGRSTRECISAGILAATVGAVKAVVEHIGIE---PNRVFLTGGAAKDVGRVTG--WRLVEGLVLRG 224
Cdd:COG1521  162 AKLPLVELEKPPSvIGKNTVEAIQSGVVYGYAGLIEGLIERIKEElgeDPKVIATGGDAPLLAPELKtiDIVDPDLVLEG 241


                 ....*....
gi 503302525 225 IVTLYLLNK 233
Cdd:COG1521  242 LRLIYERNK 250
ASKHA_NBD_PanK-III cd24015
nucleotide-binding domain (NBD) of type III pantothenate kinase (PanK-III) and similar ...
 9-225 9.79e-56

nucleotide-binding domain (NBD) of type III pantothenate kinase (PanK-III) and similar proteins; PanK (EC 2.7.1.33), also called pantothenic acid kinase, is the first enzyme in the Coenzyme A (CoA) biosynthetic pathway. It catalyzes the phosphorylation of pantothenate (vitamin B5) to form 4'-phosphopantothenate at the expense of a molecule of adenosine triphosphate (ATP), which is the rate-limiting step in CoA biosynthesis. It cannot utilize a phosphoryl donor other than ATP. Three distinct types of PanK have been identified, PanK-I, PanK-II and PanK-III. The model corresponds to PanK-III that belongs to the ASKHA (Acetate and Sugar Kinases/Hsc70/Actin) superfamily of phosphotransferases, all members of which share a common characteristic five-stranded beta sheet occurring in both the N- and C-terminal domains.


Pssm-ID: 466865 [Multi-domain]  Cd Length: 241  Bit Score: 178.23  E-value: 9.79e-56
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503302525   9 VVLDVGNTAVKAALFEGGKLFSLFTVPTARA--SEELPLQLKNLSG---TPLAYASVVPEVSRLIDKLFPQSFSVSR--- 80
Cdd:cd24015    1 LVIDIGNTNIKLGLFDGGELVKIWRLSTDKEltEDELLLLLAGIELediSGVVISSVVPSLTEVLEEALKKYFGISPlvv 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503302525  81 ----AQKLPINVNYGSKMGADRLAAMSALHHF--ESYVVVSCGTATVIDAV-KEKEFVGGYILPGLYTMAEALREKTALL 153
Cdd:cd24015   81 gpglKLGVKIAYDNPKELGADRLANAVAAAKLygRPVIVVDFGTATTIDLVdAEGEFLGGAIAPGIELSLKALHQRTAKL 160

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 503302525 154 PEVKEFKTLKP-GRSTRECISAGILAATVGAVKAVVEHI---GIEPNRVFLTGGAAKDV--GRVTGWRLVEGLVLRGI 225
Cdd:cd24015  161 PSVELIKPKKViGKNTEEAIQSGVFYGYAGLIEGIIERLkkeLGGDAKVILTGGDAKLVapYLEPIDIYDPDLTLKGL 238
Pan_kinase pfam03309
Type III pantothenate kinase; Type III pantothenate kinase catalyzes the phosphorylation of ...
 8-190 7.45e-45

Type III pantothenate kinase; Type III pantothenate kinase catalyzes the phosphorylation of pantothenate (Pan), the first step in the universal pathway of CoA biosynthesis.


Pssm-ID: 460881 [Multi-domain]  Cd Length: 205  Bit Score: 149.25  E-value: 7.45e-45
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503302525    8 LVVLDVGNTAVKAALFEGGKLFSLFTVPTA--RASEELPLQLKNLSGTP-------LAYASVVPEVSRLIDKLFPQSFSV 78
Cdd:pfam03309   1 LLAIDIGNTNIKWGLFDGDKLVAHWRISTDarRTADELGVLLRSLLRLAgidpidgVIISSVVPPLNAALERACLKYFKI 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503302525   79 ------SRAQKLPINVNY--GSKMGADRLAAMSALHHF---ESYVVVSCGTATVIDAVKEK-EFVGGYILPGLYTMAEAL 146
Cdd:pfam03309  81 eplvvgAPGIKTGLRNRYdnPKELGADRWVNAVAARELypgKPLIVVDFGTATTFDAVSADgEYLGGAIAPGIGLSLDAL 160

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*
gi 503302525  147 REKTALLPEVKEFKTLK-PGRSTRECISAGILAATVGAVKAVVEH 190
Cdd:pfam03309 161 AQGTAKLPRVEITRPGSvIGKNTVEAIQSGILYGYAGLVEGIIRR 205
PRK13318 PRK13318
type III pantothenate kinase;
8-234 1.71e-37

type III pantothenate kinase;


Pssm-ID: 237347 [Multi-domain]  Cd Length: 258  Bit Score: 131.80  E-value: 1.71e-37
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503302525   8 LVVLDVGNTAVKAALFEGGKLFSLFTVPT--ARASEELPLQLKNL---SGTPL------AYASVVP----EVSRLIDKLF 72
Cdd:PRK13318   2 LLAIDVGNTNTVFGLYEGGKLVAHWRISTdsRRTADEYGVWLKQLlglSGLDPeditgiIISSVVPsvmhSLERMCRKYF 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503302525  73 PQS--FSVSRAQKLPINVNY--GSKMGADRLA-AMSALHHFES-YVVVSCGTATVIDAV-KEKEFVGGYILPGLYTMAEA 145
Cdd:PRK13318  82 NIEplVVVGPGVKTGINIKVdnPKEVGADRIVnAVAAYELYGGpLIVVDFGTATTFDVVsAKGEYLGGVIAPGINISADA 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503302525 146 LREKTALLPEVkEFKtlKP----GRSTRECISAGILAATVGAVKAVVEHIGIE---PNRVFLTGGAAkdvgrvtgwRLVE 218
Cdd:PRK13318 162 LFQRAAKLPRV-EIT--KPdsviGKNTVEAMQSGIYYGYVGLVEGIVKRIKEElgkDPKVIATGGLA---------PLFA 229

                        250       260
                 ....*....|....*....|....*..
gi 503302525 219 G-----------LVLRGIVTLYLLNKG 234
Cdd:PRK13318 230 EesdtidivdpdLTLKGLRLIYERNKE 256
baf TIGR00671
pantothenate kinase, type III; This model describes a family of proteins found in a single ...
 8-206 2.80e-32

pantothenate kinase, type III; This model describes a family of proteins found in a single copy in at least ten different early completed bacterial genomes. The only characterized member of the family is Bvg accessory factor (Baf), a protein required, in addition to the regulatory operon bvgAS, for heterologous transcription of the Bordetella pertussis toxin operon (ptx) in E. coli. [Biosynthesis of cofactors, prosthetic groups, and carriers, Pantothenate and coenzyme A]


Pssm-ID: 273210 [Multi-domain]  Cd Length: 243  Bit Score: 117.96  E-value: 2.80e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503302525    8 LVVLDVGNTAVKAALFEGGKLFSLFTVPTAR--ASEELPLQLKNL---SGTPLAYASVVPEVSRLIDKLFPQSFSVSRAQ 82
Cdd:TIGR00671   1 LLLIDVGNTRIVFALNSGNKVYQFWRLATNLmkTYDEHSEFLKELfgkSLNKAFISSVVPELTEAVRNMIPKIKNIKPEI 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503302525   83 KLPINVNYGS-------KMGADR-LAAMSALHHFES-YVVVSCGTATVIDAVK-EKEFVGGYILPGLYTMAEALREKTAL 152
Cdd:TIGR00671  81 FFPLVYDGLPnlykspkELGIDRvANALAAIKFYGFnVVVVDAGTALTIDLVDqEGKFLGGAIAPGLGISLHALKDRAAA 160

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 503302525  153 LPEVK-EFKTLKPGRSTRECISAGILAATVGAVKAVVEHIGIEPNRVF---LTGGAAK 206
Cdd:TIGR00671 161 LPKFEiARPDEVLGKSTREAVQSGAVYGVLGLIQGLLKDWKKYFKRKFavvITGGDGK 218
 
Name Accession Description Interval E-value
CoaX COG1521
Pantothenate kinase type III [Coenzyme transport and metabolism];
8-233 7.34e-63

Pantothenate kinase type III [Coenzyme transport and metabolism];


Pssm-ID: 441130 [Multi-domain]  Cd Length: 250  Bit Score: 196.92  E-value: 7.34e-63
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503302525   8 LVVLDVGNTAVKAALFEGGKLFSLFTVPTARA-SEELPLQLKNL------SGTPLAYASVVPEVSRLIDKLFPQSFS--- 77
Cdd:COG1521    2 LLAIDIGNTRIKWGLFDGGELLASWRLATDRRtADELAELLRQLlaallpDIEGVIISSVVPPLTEALEELLRKYFGvpp 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503302525  78 --VSRAQKLPINVNYG--SKMGADRLAAMSALHHF--ESYVVVSCGTATVIDAV-KEKEFVGGYILPGLYTMAEALREKT 150
Cdd:COG1521   82 lvVGPGVKTGLKNAYDnpEELGADRIANAVAARELygGPLLVVDFGTATTFDVVdADGEYLGGAIAPGLGLSLEALHQRT 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503302525 151 ALLPEVKEFKTLK-PGRSTRECISAGILAATVGAVKAVVEHIGIE---PNRVFLTGGAAKDVGRVTG--WRLVEGLVLRG 224
Cdd:COG1521  162 AKLPLVELEKPPSvIGKNTVEAIQSGVVYGYAGLIEGLIERIKEElgeDPKVIATGGDAPLLAPELKtiDIVDPDLVLEG 241


                 ....*....
gi 503302525 225 IVTLYLLNK 233
Cdd:COG1521  242 LRLIYERNK 250
ASKHA_NBD_PanK-III cd24015
nucleotide-binding domain (NBD) of type III pantothenate kinase (PanK-III) and similar ...
 9-225 9.79e-56

nucleotide-binding domain (NBD) of type III pantothenate kinase (PanK-III) and similar proteins; PanK (EC 2.7.1.33), also called pantothenic acid kinase, is the first enzyme in the Coenzyme A (CoA) biosynthetic pathway. It catalyzes the phosphorylation of pantothenate (vitamin B5) to form 4'-phosphopantothenate at the expense of a molecule of adenosine triphosphate (ATP), which is the rate-limiting step in CoA biosynthesis. It cannot utilize a phosphoryl donor other than ATP. Three distinct types of PanK have been identified, PanK-I, PanK-II and PanK-III. The model corresponds to PanK-III that belongs to the ASKHA (Acetate and Sugar Kinases/Hsc70/Actin) superfamily of phosphotransferases, all members of which share a common characteristic five-stranded beta sheet occurring in both the N- and C-terminal domains.


Pssm-ID: 466865 [Multi-domain]  Cd Length: 241  Bit Score: 178.23  E-value: 9.79e-56
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503302525   9 VVLDVGNTAVKAALFEGGKLFSLFTVPTARA--SEELPLQLKNLSG---TPLAYASVVPEVSRLIDKLFPQSFSVSR--- 80
Cdd:cd24015    1 LVIDIGNTNIKLGLFDGGELVKIWRLSTDKEltEDELLLLLAGIELediSGVVISSVVPSLTEVLEEALKKYFGISPlvv 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503302525  81 ----AQKLPINVNYGSKMGADRLAAMSALHHF--ESYVVVSCGTATVIDAV-KEKEFVGGYILPGLYTMAEALREKTALL 153
Cdd:cd24015   81 gpglKLGVKIAYDNPKELGADRLANAVAAAKLygRPVIVVDFGTATTIDLVdAEGEFLGGAIAPGIELSLKALHQRTAKL 160

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 503302525 154 PEVKEFKTLKP-GRSTRECISAGILAATVGAVKAVVEHI---GIEPNRVFLTGGAAKDV--GRVTGWRLVEGLVLRGI 225
Cdd:cd24015  161 PSVELIKPKKViGKNTEEAIQSGVFYGYAGLIEGIIERLkkeLGGDAKVILTGGDAKLVapYLEPIDIYDPDLTLKGL 238
Pan_kinase pfam03309
Type III pantothenate kinase; Type III pantothenate kinase catalyzes the phosphorylation of ...
 8-190 7.45e-45

Type III pantothenate kinase; Type III pantothenate kinase catalyzes the phosphorylation of pantothenate (Pan), the first step in the universal pathway of CoA biosynthesis.


Pssm-ID: 460881 [Multi-domain]  Cd Length: 205  Bit Score: 149.25  E-value: 7.45e-45
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503302525    8 LVVLDVGNTAVKAALFEGGKLFSLFTVPTA--RASEELPLQLKNLSGTP-------LAYASVVPEVSRLIDKLFPQSFSV 78
Cdd:pfam03309   1 LLAIDIGNTNIKWGLFDGDKLVAHWRISTDarRTADELGVLLRSLLRLAgidpidgVIISSVVPPLNAALERACLKYFKI 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503302525   79 ------SRAQKLPINVNY--GSKMGADRLAAMSALHHF---ESYVVVSCGTATVIDAVKEK-EFVGGYILPGLYTMAEAL 146
Cdd:pfam03309  81 eplvvgAPGIKTGLRNRYdnPKELGADRWVNAVAARELypgKPLIVVDFGTATTFDAVSADgEYLGGAIAPGIGLSLDAL 160

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*
gi 503302525  147 REKTALLPEVKEFKTLK-PGRSTRECISAGILAATVGAVKAVVEH 190
Cdd:pfam03309 161 AQGTAKLPRVEITRPGSvIGKNTVEAIQSGILYGYAGLVEGIIRR 205
PRK13318 PRK13318
type III pantothenate kinase;
8-234 1.71e-37

type III pantothenate kinase;


Pssm-ID: 237347 [Multi-domain]  Cd Length: 258  Bit Score: 131.80  E-value: 1.71e-37
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503302525   8 LVVLDVGNTAVKAALFEGGKLFSLFTVPT--ARASEELPLQLKNL---SGTPL------AYASVVP----EVSRLIDKLF 72
Cdd:PRK13318   2 LLAIDVGNTNTVFGLYEGGKLVAHWRISTdsRRTADEYGVWLKQLlglSGLDPeditgiIISSVVPsvmhSLERMCRKYF 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503302525  73 PQS--FSVSRAQKLPINVNY--GSKMGADRLA-AMSALHHFES-YVVVSCGTATVIDAV-KEKEFVGGYILPGLYTMAEA 145
Cdd:PRK13318  82 NIEplVVVGPGVKTGINIKVdnPKEVGADRIVnAVAAYELYGGpLIVVDFGTATTFDVVsAKGEYLGGVIAPGINISADA 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503302525 146 LREKTALLPEVkEFKtlKP----GRSTRECISAGILAATVGAVKAVVEHIGIE---PNRVFLTGGAAkdvgrvtgwRLVE 218
Cdd:PRK13318 162 LFQRAAKLPRV-EIT--KPdsviGKNTVEAMQSGIYYGYVGLVEGIVKRIKEElgkDPKVIATGGLA---------PLFA 229

                        250       260
                 ....*....|....*....|....*..
gi 503302525 219 G-----------LVLRGIVTLYLLNKG 234
Cdd:PRK13318 230 EesdtidivdpdLTLKGLRLIYERNKE 256
PRK13321 PRK13321
type III pantothenate kinase;
7-233 8.03e-37

type III pantothenate kinase;


Pssm-ID: 237349 [Multi-domain]  Cd Length: 256  Bit Score: 129.99  E-value: 8.03e-37
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503302525   7 KLVVLDVGNTAVKAALFEGGKLFSLFTVPT--ARASEELPLQLKNL---------SGTPLAYASVVPEVSRLIDKLFPQS 75
Cdd:PRK13321   1 MLLLIDVGNTNIKLGVFDGDRLLRSFRLPTdkSRTSDELGILLLSLfrhagldpeDIRAVVISSVVPPLNYSLESACKRY 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503302525  76 FSVS--RAQ---KLPINVNYGS--KMGADRLAAMSA---LHHFESYVVVSCGTATVIDAV-KEKEFVGGYILPGLYTMAE 144
Cdd:PRK13321  81 FGIKplFVGpgiKTGLKIRYDNprEVGADRIVNAVAarrLYPDRNLIVVDFGTATTFDCVsGKGEYLGGAICPGILISME 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503302525 145 ALREKTALLPEVkEF--KTLKPGRSTRECISAGILAATVGAVKAVVEHIGIE---PNRVFLTGGAAKDVGRVTGW--RLV 217
Cdd:PRK13321 161 ALSQKTAKLPRV-EIakPPSAIGKSTVSSIQSGLYYGYAGLVEGIVARIKAElggPPRVIATGGFASLIAKESRCfdHVD 239

                        250
                 ....*....|....*.
gi 503302525 218 EGLVLRGIVTLYLLNK 233
Cdd:PRK13321 240 PDLLLEGLRILYQMNR 255
PRK13320 PRK13320
type III pantothenate kinase;
8-233 3.21e-35

type III pantothenate kinase;


Pssm-ID: 237348 [Multi-domain]  Cd Length: 244  Bit Score: 125.74  E-value: 3.21e-35
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503302525   8 LVVLDVGNTAVKAALFEGGKLFSLFTVPTARASEEL-PLQLKNLSGTPLAYASVVPEVSRLIDKLFPQSFSV---SRAQK 83
Cdd:PRK13320   4 NLVIDIGNTTTKLAVFEGDELLEVFVVSTEGVEESLeKLLAKYPAIRDAIVSSVVPLAEEAFSALLKLLFAVlelDSETP 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503302525  84 LPINVNYGSK--MGADRLAAMS-ALHHFESY--VVVSCGTATVIDAVKEK-EFVGGYILPGLYTMAEALREKTALLPEVK 157
Cdd:PRK13320  84 LPFRNDYDTPetLGADRLALCAgARYLFPGKnvLAIDAGTAITYDVLDSEgVYLGGLISPGLEMRFKALHEFTARLPLVT 163

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503302525 158 EFKTLKP-GRSTRECISAGILAATVGAVKAVVEHIG--IEPNRVFLTGGAAKDV-GRVTG-WRLVEGLVLRGIVTLYLLN 232
Cdd:PRK13320 164 IEGPIPLiGRSTEECIRSGVVWGCVAEIEGLIEAYKskLPELLVILTGGDAPFLaSRLKNtIFADEHAVLKGLNRILEYN 243


                 .
gi 503302525 233 K 233
Cdd:PRK13320 244 K 244
baf TIGR00671
pantothenate kinase, type III; This model describes a family of proteins found in a single ...
 8-206 2.80e-32

pantothenate kinase, type III; This model describes a family of proteins found in a single copy in at least ten different early completed bacterial genomes. The only characterized member of the family is Bvg accessory factor (Baf), a protein required, in addition to the regulatory operon bvgAS, for heterologous transcription of the Bordetella pertussis toxin operon (ptx) in E. coli. [Biosynthesis of cofactors, prosthetic groups, and carriers, Pantothenate and coenzyme A]


Pssm-ID: 273210 [Multi-domain]  Cd Length: 243  Bit Score: 117.96  E-value: 2.80e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503302525    8 LVVLDVGNTAVKAALFEGGKLFSLFTVPTAR--ASEELPLQLKNL---SGTPLAYASVVPEVSRLIDKLFPQSFSVSRAQ 82
Cdd:TIGR00671   1 LLLIDVGNTRIVFALNSGNKVYQFWRLATNLmkTYDEHSEFLKELfgkSLNKAFISSVVPELTEAVRNMIPKIKNIKPEI 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503302525   83 KLPINVNYGS-------KMGADR-LAAMSALHHFES-YVVVSCGTATVIDAVK-EKEFVGGYILPGLYTMAEALREKTAL 152
Cdd:TIGR00671  81 FFPLVYDGLPnlykspkELGIDRvANALAAIKFYGFnVVVVDAGTALTIDLVDqEGKFLGGAIAPGLGISLHALKDRAAA 160

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 503302525  153 LPEVK-EFKTLKPGRSTRECISAGILAATVGAVKAVVEHIGIEPNRVF---LTGGAAK 206
Cdd:TIGR00671 161 LPKFEiARPDEVLGKSTREAVQSGAVYGVLGLIQGLLKDWKKYFKRKFavvITGGDGK 218
PRK13322 PRK13322
pantothenate kinase; Reviewed
 11-224 3.64e-31

pantothenate kinase; Reviewed


Pssm-ID: 237350 [Multi-domain]  Cd Length: 246  Bit Score: 115.05  E-value: 3.64e-31
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503302525  11 LDVGNTAVKAALFEGGKLfSLFTVPTARASEELPLQLKNLSGTPLA---YASVV-PEVSRLIDKLFPQSFSVS-----RA 81
Cdd:PRK13322   5 LDCGNSRLKWRVIDNGGQ-IIEHGAHLDSPAELLLGLANLASLAPTrcrIVSVLsEEETARLVAILEKRLGIPvvfakVA 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503302525  82 QKLPINVN-Y--GSKMGADRLAAMSALHHF--ESYVVVSCGTATVIDAVK-EKEFVGGYILPGLYTMAEALREKTALLPE 155
Cdd:PRK13322  84 AELAGVRNgYedPEQLGIDRWLALLGAFHLakNACLVIDCGTAVTIDLVDaDGQHLGGYICPGLYLMRDALRTHTRRIRY 163

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 503302525 156 V-KEFKTLKPGRSTRECISAGILAATVGAVKAVVEHIG---IEPNRVFLTGGAAKDVGR-VTGWRLVEGLVLRG 224
Cdd:PRK13322 164 DdGTADSLSPGRNTVDAVERGCLLMLRGFIESQLEQARelwGPDFEIFLTGGDAPLLADhLPQARVVPDLVFVG 237
PRK13328 PRK13328
type III pantothenate kinase;
6-224 3.62e-23

type III pantothenate kinase;


Pssm-ID: 237352 [Multi-domain]  Cd Length: 255  Bit Score: 94.31  E-value: 3.62e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503302525   6 RKLVVLDVGNTAVKAALFEGG-KLFSLFTVPTARASEELPlQLKNLSGTPLAYASVV--PEVSRLIDKLF-------PQS 75
Cdd:PRK13328   1 AMILLIDAGNSRIKWAWADAGrPWVHSGAFAHGLDAALAP-DWSALPAPRGAWISNVagPAVAARLDALLaarwpglPVT 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503302525  76 FSVSRAQKLPINVNYG--SKMGADRLAAMSALHHF---ESYVVVSCGTATVIDAVK-EKEFVGGYILPGLYTMAEALREK 149
Cdd:PRK13328  80 WVRSRAAQCGVRNGYRepAQLGSDRWAGLIGARAAfpgEHLLIATFGTATTLDALRaDGRFAGGLILPGLALMMRALARH 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503302525 150 TALLPEVKEFKTLKPGRS-------TRECISAGILAATVGAV----KAVVEHIGIEPnRVFLTGGAAKDVGRV--TGWRL 216
Cdd:PRK13328 160 TAQLPTLDVDAASAAAGAvapfaddTPDAISAGCLAAQAGLIerawRDLAARWQAPV-RLVLSGGAADAVAPAltVPHTR 238


                 ....*...
gi 503302525 217 VEGLVLRG 224
Cdd:PRK13328 239 HDNLVLLG 246
PRK13331 PRK13331
pantothenate kinase; Reviewed
 1-225 8.09e-23

pantothenate kinase; Reviewed


Pssm-ID: 237353 [Multi-domain]  Cd Length: 251  Bit Score: 93.19  E-value: 8.09e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503302525   1 MQSTERKLVVLDVGNTAVKAALFEGGKLfsLFTVPTARASEELPLQLKN------LSGTPLAYASVVPEVSrlidKLFPQ 74
Cdd:PRK13331   2 MFHTSNEWLALMIGNSRLHWGYFSGETL--VKTWDTPHLDESIIQLLLPgqtlliVAPNPLVIASVVPQQT----ELWQT 75

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503302525  75 SFSVSRAQ--KLPINVNYgSKMGADR-LAAMSALhhfESY----VVVSCGTATVIDAV-KEKEFVGGYILPGLYTMAEAL 146
Cdd:PRK13331  76 YPNVRLITldDIPLNNLY-PTLGIDRaLALWGAG---QTYgfpcLVIDAGTALTFTGVdSDRTLVGGAILPGLGLQLRSL 151

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503302525 147 REKTALLPEVKEFKTLKP--GRSTRECISAGILAATVGAVKAVVEHIGIE-PNR-VFLTGG---------AAKDVGRVTG 213
Cdd:PRK13331 152 ADKTAALPQVELPPPLPPrwATNTQEAIQSGVIYTILAGLRDFIEDWLSLfPDGkIVLTGGdgellhnylQDLDPELAQR 231

                        250
                 ....*....|..
gi 503302525 214 WRLVEGLVLRGI 225
Cdd:PRK13331 232 LRVDPNLIFWGI 243
PRK13329 PRK13329
pantothenate kinase; Reviewed
 8-228 5.08e-18

pantothenate kinase; Reviewed


Pssm-ID: 183979 [Multi-domain]  Cd Length: 249  Bit Score: 80.42  E-value: 5.08e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503302525   8 LVVLDVGNTAVKAALFE----GGKLF---SLFTVPTARASEELPLQLKNLS---GTPLAYASVVPEVSRLID--KLFPQS 75
Cdd:PRK13329   3 FLAIDVGNTRLKWGLYDaaqpGAALLahgAEFLAEIDRLAEGAWAGLPAPArvlGCNVAGDAVARRVAEQLElwDVAPRW 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503302525  76 FSVSRAQKLPIN-VNYGSKMGADRLAAMSALHHFESY--VVVSCGTATVIDAV-KEKEFVGGYILPGLYTMAEALREKTA 151
Cdd:PRK13329  83 VVASAAECGVRNgYDHPARLGADRWVALIGARHGPARpcLVVMVGTAVTVDALdADGEFLGGLILPGHGLMLRALESGTA 162

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503302525 152 LLP----EVKEFKTlkpgrSTRECISAGILAATVGAVKAVVEHI----GIEPnRVFLTGGAAKDVGRVTG--WRLVEGLV 221
Cdd:PRK13329 163 GLHvptgEVREFPT-----NTSDALTSGGTQAIAGAVERMFRHLaqhcGAEP-ECLLTGGAAWKLAPSLTvpFELVDNLV 236


                 ....*..
gi 503302525 222 LRGIVTL 228
Cdd:PRK13329 237 LDGLLVI 243
PRK13333 PRK13333
type III pantothenate kinase;
8-206 1.09e-15

type III pantothenate kinase;


Pssm-ID: 183981 [Multi-domain]  Cd Length: 206  Bit Score: 73.04  E-value: 1.09e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503302525   8 LVVLDVGNTavKAALFEGGKLFSLFtvptarASEELPLQLKNlsgtPLAYASVVPEVSRLIDKLFPQSFSVSRAQKLPin 87
Cdd:PRK13333   1 MLLCDIGNT--NAHFYQNGKIFSLS------IEEFKRFKIDQ----EIYYISVNEELEKKLLKCYPNAINLEPYFELD-- 66

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503302525  88 vNYGSKMGADRLAAMSALhhfESYVVVSCGTATVIDAVKEKEFVGGYILPGLYTMAEALREKTALLPevKEFKTL----K 163
Cdd:PRK13333  67 -TIYQGLGIDRIAACYAI---EDGVVVDAGSAITVDIMSNGIHLGGFILPGIAAYKKAYKKISPRLK--QPFNAQisldA 140

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|...
gi 503302525 164 PGRSTRECISAGILaatvGAVKAVVEHIGiEPNRVFLTGGAAK 206
Cdd:PRK13333 141 LPQNTRDAISYGVI----KSIILLIEKLA-KNKKIYFTGGDGK 178
PRK13324 PRK13324
type III pantothenate kinase;
8-232 7.43e-09

type III pantothenate kinase;


Pssm-ID: 106284 [Multi-domain]  Cd Length: 258  Bit Score: 54.63  E-value: 7.43e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503302525   8 LVVLDVGNTAVKAALFEGGKLFSLFTVPTA--------------RASEELPLQLKNLSGTplAYASVVPEV-----SRLI 68
Cdd:PRK13324   2 LLVMDMGNSHIHIGVFDGDRIVSQIRYATSsvdstsdqmgvflrQALRENSVDLGKIDGC--GISSVVPHLnyslgSAVI 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503302525  69 DKLFPQSFSVS-RAQKLPINVNYGSKMGADRLAA-MSAL--HHFESYVVVSCGTATVIDAV-KEKEFVGGYILPGLYTMA 143
Cdd:PRK13324  80 KYFNIKPFFISmDTTDLDMSAVEAHQVGADRIAScISAIadHPNKDLLIIDLGTATTFDLVtKDKKYLSGSIMPGVKLSL 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503302525 144 EALREKTALLPEVKEFK-TLKPGRSTRECISAGILAATVGAVKAV----VEHIGiEPNRVFLTGGAA---KDVGRVTgwR 215
Cdd:PRK13324 160 NALCQGASQLSSVTIVKpEVAIGYDTKTNIRSGLYYGHLGALKELkrrsVEEFG-SPVYTIATGGFAglfKEEDIFN--E 236

                        250
                 ....*....|....*..
gi 503302525 216 LVEGLVLRGIVTLYLLN 232
Cdd:PRK13324 237 ISPDLILRGIRIAFLEN 253
PRK13325 PRK13325
bifunctional biotin--[acetyl-CoA-carboxylase] ligase/type III pantothenate kinase;
79-236 5.74e-08

bifunctional biotin--[acetyl-CoA-carboxylase] ligase/type III pantothenate kinase;


Pssm-ID: 183976 [Multi-domain]  Cd Length: 592  Bit Score: 52.79  E-value: 5.74e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503302525  79 SRAQKLPINVNY--GSKMGADRLAAMSALHHFE--SYVVVSCGTATVIDAVKEK-EFVGGYILPGLYTMAEALREKTALL 153
Cdd:PRK13325 415 SSAQALGIRNHYrhPEEHGSDRWFNALGSRRFSrnACVVVSCGTAVTVDALTDDgHYLGGTIMPGFHLMKESLAVRTANL 494

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503302525 154 PEVKEFKTLKPgRSTRECISAGILAATVGAVKA----VVEHIGI-EPNRVFLTGGAAKDVGRV--------TGWRLVEGL 220
Cdd:PRK13325 495 NRHAGKRYPFP-TTTGNAVASGMMDAVCGSVMMmhgrLKEKTGAgKPVDVIITGGGAAKVAEAlppaflaeNTVRVADNL 573

                        170
                 ....*....|....*.
gi 503302525 221 VLRGIVTLyLLNKGGK 236
Cdd:PRK13325 574 VIHGLLNL-IAAEGGE 588
PRK13326 PRK13326
type III pantothenate kinase;
9-177 5.32e-03

type III pantothenate kinase;


Pssm-ID: 237351  Cd Length: 262  Bit Score: 37.07  E-value: 5.32e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503302525   9 VVLDVGNTAVKAALFEGGKLFSLFTVPTAR--ASEELPLQLK---NLSGTPLAYASVVPevsrLIDKLFPQS-FSVSRAQ 82
Cdd:PRK13326   9 LIIDIGNTSISFALYKDNKMQIFCKLKTKLdlSFDELYSFLKekfDFKVNQVFVSSVVP----VIDKVLINViFSLYKVK 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503302525  83 KLPI--NVNY--------------GSKMGADRLAAMSAlHHFESYVVVSCGTATVIDAVKEKE-FVGGYILPGLYTMAEA 145
Cdd:PRK13326  85 PLFIgfDLNYdlsfnpynsnkfllGSDVFANLVGAIEY-YNINDALVVDLGTACTIFAVSRQDgILGGLINGGPFTNLNA 163

                        170       180       190
                 ....*....|....*....|....*....|....*.
gi 503302525 146 LREKTALLpevKEFKTLKP----GRSTRECISAGIL 177
Cdd:PRK13326 164 LLDNAYLL---KDFNLSVPknllGLSTSDSVNSGVI 196
PRK13327 PRK13327
type III pantothenate kinase;
10-154 6.97e-03

type III pantothenate kinase;


Pssm-ID: 183977 [Multi-domain]  Cd Length: 242  Bit Score: 36.73  E-value: 6.97e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503302525  10 VLDVGNTAVKAALFEGGKLFSLFTVP------TARASEELPlqlknlSGTPLAYASVVPE--VSRLIDKL---FPQSFSV 78
Cdd:PRK13327   5 LFDLGNSRFKYAPLHGGRAGDVQAWAhgaeamDAAALAALP------SGRVAYVASVAAPalTQRVLACLqerFEQVRVV 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503302525  79 SRAQKLP-INVNYG--SKMGADRLAAMSALHHFESYVVVSCGTATVIDAV-KEKEFVGGYILPGLYTMAEALREKTALLP 154
Cdd:PRK13327  79 RTAAACAgVRIAYAdpSRFGVDRFLALLGARGDAPVLVVGVGTALTIDLLgADGLHHGGRIAASPTTMREALHARAVQLP 158
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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