|
Name |
Accession |
Description |
Interval |
E-value |
| NtrY |
COG5000 |
Signal transduction histidine kinase NtrY involved in nitrogen fixation and metabolism ... |
27-438 |
2.45e-94 |
|
Signal transduction histidine kinase NtrY involved in nitrogen fixation and metabolism regulation [Signal transduction mechanisms];
Pssm-ID: 444024 [Multi-domain] Cd Length: 422 Bit Score: 290.33 E-value: 2.45e-94
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503313842 27 KIHFMHLYIIEGLIAFI--LLYLIVFYRKIVKPMNTIGCGMELLREQDFSSRLSQVGQYEADRIVNIFNRMMEQLKNERL 104
Cdd:COG5000 4 QILFLLLLLLIALLLLLlaLWLALLLARRLTRPLRRLAEATRAVAAGDLSVRLPVTGDDEIGELARAFNRMTDQLKEQRE 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503313842 105 RLREQNHFLDLLIQASPMGVVITTLDGEVSQVNPMAVKMLGVRLEEVIDKPLDQVDSPLATELAVIPKDETAV-----VR 179
Cdd:COG5000 84 ELEERRRYLETILENLPAGVIVLDADGRITLANPAAERLLGIPLEELIGKPLEELLPELDLAELLREALERGWqeeieLT 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503313842 180 LNDANIYKCTHSTFIDRGFkhpFFLIERMTEEVMRAEKRAYEKVIRMIAHEVNNTTAGITSTLDTVEQALSA--EEGMDD 257
Cdd:COG5000 164 RDGRRTLLVRASPLRDDGY---VIVFDDITELLRAERLAAWGELARRIAHEIKNPLTPIQLSAERLRRKLADklEEDRED 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503313842 258 ICDVMRVCTERCFSMSRFITRFADVVKIPEPTLASVRLNDLVAMCKRFMEGMCNDRKISLRLECDPEIGSVRLDASLFEQ 337
Cdd:COG5000 241 LERALDTIIRQVDRLKRIVDEFLDFARLPEPQLEPVDLNELLREVLALYEPALKEKDIRLELDLDPDLPEVLADRDQLEQ 320
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503313842 338 VLVNIIKNAAESIDSfvgesgrRGEIIIRTVAP---AYIEVIDNGSGISKEVEAKLFSPFFSTKPNGQGIGLVFIREVLI 414
Cdd:COG5000 321 VLINLLKNAIEAIEE-------GGEIEVSTRREdgrVRIEVSDNGPGIPEEVLERIFEPFFTTKPKGTGLGLAIVKKIVE 393
|
410 420
....*....|....*....|....
gi 503313842 415 RHNCTFSLRTYNDGLTRFRIMFNA 438
Cdd:COG5000 394 EHGGTIELESRPGGGTTFTIRLPL 417
|
|
| NtrB |
COG3852 |
Signal transduction histidine kinase NtrB, nitrogen specific [Signal transduction mechanisms]; |
105-436 |
1.62e-48 |
|
Signal transduction histidine kinase NtrB, nitrogen specific [Signal transduction mechanisms];
Pssm-ID: 443061 [Multi-domain] Cd Length: 361 Bit Score: 169.26 E-value: 1.62e-48
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503313842 105 RLREQNHFLDLLIQASPMGVVITTLDGEVSQVNPMAVKMLGVRLEEVIDKPLDQV---DSPLATELA-------VIPKDE 174
Cdd:COG3852 1 ALRESEELLRAILDSLPDAVIVLDADGRITYVNPAAERLLGLSAEELLGRPLAELfpeDSPLRELLEralaegqPVTERE 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503313842 175 TAVVRLNDANIY-KCTHSTFIDRGFKHPFFLI-------ERMTEEVMRAEK-RAYEKVIRMIAHEVNNTTAGITSTLDTV 245
Cdd:COG3852 81 VTLRRKDGEERPvDVSVSPLRDAEGEGGVLLVlrditerKRLERELRRAEKlAAVGELAAGLAHEIRNPLTGIRGAAQLL 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503313842 246 EQALSAEEGMDDIcDVMRVCTERcfsMSRFITRFADVVKIPEPTLASVRLNDLVAMCKRFMEGMCnDRKISLRLECDPEI 325
Cdd:COG3852 161 ERELPDDELREYT-QLIIEEADR---LNNLVDRLLSFSRPRPPEREPVNLHEVLERVLELLRAEA-PKNIRIVRDYDPSL 235
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503313842 326 GSVRLDASLFEQVLVNIIKNAAESIdsfvgesGRRGEIIIRTVA-------------PAYIEVIDNGSGISKEVEAKLFS 392
Cdd:COG3852 236 PEVLGDPDQLIQVLLNLVRNAAEAM-------PEGGTITIRTRVerqvtlgglrprlYVRIEVIDNGPGIPEEILDRIFE 308
|
330 340 350 360
....*....|....*....|....*....|....*....|....
gi 503313842 393 PFFSTKPNGQGIGLVFIREVLIRHNCTFSLRTYNDGLTRFRIMF 436
Cdd:COG3852 309 PFFTTKEKGTGLGLAIVQKIVEQHGGTIEVESEPGKGTTFRIYL 352
|
|
| COG4191 |
COG4191 |
Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal ... |
205-406 |
2.20e-38 |
|
Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal transduction mechanisms];
Pssm-ID: 443345 [Multi-domain] Cd Length: 361 Bit Score: 142.24 E-value: 2.20e-38
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503313842 205 IERMTEEVMRAE---KRAYEKVIRM------------IAHEVNNTTAGITSTLDTVEQALSAEEGMDDICDVMRVCTERC 269
Cdd:COG4191 112 LERDITELERAEeelRELQEQLVQSeklaalgelaagIAHEINNPLAAILGNAELLRRRLEDEPDPEELREALERILEGA 191
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503313842 270 FSMSRFITRFADVVKIPEPTLASVRLNDLVAMCKRFMEGMCNDRKISLRLECDPEIGSVRLDASLFEQVLVNIIKNAAES 349
Cdd:COG4191 192 ERAAEIVRSLRAFSRRDEEEREPVDLNELIDEALELLRPRLKARGIEVELDLPPDLPPVLGDPGQLEQVLLNLLINAIDA 271
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|
gi 503313842 350 IdsfvgESGRRGEIIIRTVAP---AYIEVIDNGSGISKEVEAKLFSPFFSTKPNGQGIGL 406
Cdd:COG4191 272 M-----EEGEGGRITISTRREgdyVVISVRDNGPGIPPEVLERIFEPFFTTKPVGKGTGL 326
|
|
| PRK11360 |
PRK11360 |
two-component system sensor histidine kinase AtoS; |
27-417 |
4.32e-31 |
|
two-component system sensor histidine kinase AtoS;
Pssm-ID: 236901 [Multi-domain] Cd Length: 607 Bit Score: 125.85 E-value: 4.32e-31
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503313842 27 KIHFMHLYIIEGLIAFILLYL---IVFYRKIVKPMNTIGCGMELLrEQDFSSRLSQV-GqyEADRIVNIFNRMMEqlkne 102
Cdd:PRK11360 184 QAWKMDRRIYAVLAAGLVIGLlliFLLSRRFSANVDIIKDGLSTL-ENDLSTRLPPLpG--ELGEISQAINNLAQ----- 255
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503313842 103 rlRLREQNHFLDLLIQASPMGVVITTLDGEVSQVNPMAVKMLGVRLEEVIDKPLDQV---DSPLA-------------TE 166
Cdd:PRK11360 256 --ALRETRSLNELILESIADGVIAIDRQGKITTMNPAAEVITGLQRHELVGKPYSELfppNTPFAsplldtlehgtehVD 333
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503313842 167 LAVI-PKDETAVVRLNDANIYKCTHS-------TFIDRGFKhpffliERMTEEVMRAEKRA-YEKVIRMIAHEVNNTTAG 237
Cdd:PRK11360 334 LEISfPGRDRTIELSVSTSLLHNTHGemigalvIFSDLTER------KRLQRRVARQERLAaLGELVAGVAHEIRNPLTA 407
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503313842 238 ITSTLDTVEQALSAEEGMDDICDVMRVCTercfSMSRFITRFADVVKIPEPTLASVRLNDLVAMCKRFMEGMCNDRKISL 317
Cdd:PRK11360 408 IRGYVQIWRQQTSDPPSQEYLSVVLREVD----RLNKVIDQLLEFSRPRESQWQPVSLNALVEEVLQLFQTAGVQARVDF 483
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503313842 318 RLECDPEIGSVRLDASLFEQVLVNIIKNAAESIdsfvgesGRRGEIIIRTVAPA----YIEVIDNGSGISKEVEAKLFSP 393
Cdd:PRK11360 484 ETELDNELPPIWADPELLKQVLLNILINAVQAI-------SARGKIRIRTWQYSdgqvAVSIEDNGCGIDPELLKKIFDP 556
|
410 420
....*....|....*....|....
gi 503313842 394 FFSTKPNGQGIGLVFIREVLIRHN 417
Cdd:PRK11360 557 FFTTKAKGTGLGLALSQRIINAHG 580
|
|
| BaeS |
COG0642 |
Signal transduction histidine kinase [Signal transduction mechanisms]; |
202-436 |
2.36e-28 |
|
Signal transduction histidine kinase [Signal transduction mechanisms];
Pssm-ID: 440407 [Multi-domain] Cd Length: 328 Bit Score: 114.23 E-value: 2.36e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503313842 202 FFLIERMTEEVMRAEKRAYEKVIRMIAHEVNNTTAGITSTLDTVEQALSAEegMDDICDVMRVCTERcfsMSRFITRFAD 281
Cdd:COG0642 92 LLLLLLALLLLLEEANEAKSRFLANVSHELRTPLTAIRGYLELLLEELDEE--QREYLETILRSADR---LLRLINDLLD 166
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503313842 282 VVKI----PEPTLASVRLNDLVAMCKRFMEGMCNDRKISLRLECDPEIGSVRLDASLFEQVLVNIIKNAAESidsfvGES 357
Cdd:COG0642 167 LSRLeagkLELEPEPVDLAELLEEVVELFRPLAEEKGIELELDLPDDLPTVRGDPDRLRQVLLNLLSNAIKY-----TPE 241
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503313842 358 GrrGEIIIRTVAP---AYIEVIDNGSGISKEVEAKLFSPFFSTKP----NGQGIGLVFIREVLIRHNCTFSLRTYNDGLT 430
Cdd:COG0642 242 G--GTVTVSVRREgdrVRISVEDTGPGIPPEDLERIFEPFFRTDPsrrgGGTGLGLAIVKRIVELHGGTIEVESEPGKGT 319
|
....*.
gi 503313842 431 RFRIMF 436
Cdd:COG0642 320 TFTVTL 325
|
|
| KdpD |
COG2205 |
K+-sensing histidine kinase KdpD [Signal transduction mechanisms]; |
205-436 |
6.41e-26 |
|
K+-sensing histidine kinase KdpD [Signal transduction mechanisms];
Pssm-ID: 441807 [Multi-domain] Cd Length: 239 Bit Score: 104.99 E-value: 6.41e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503313842 205 IERMTEEVMRAEkRAYEKVIRMIAHEVNNTTAGITSTLDTVEQALS-AEEGMDDICDVMRVCTERcfsMSRFITRFADVV 283
Cdd:COG2205 2 LEEALEELEELE-RLKSEFLANVSHELRTPLTSILGAAELLLDEEDlSPEERRELLEIIRESAER---LLRLIEDLLDLS 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503313842 284 KI----PEPTLASVRLNDLVAMCKRFMEGMCNDRKISLRLECDPEIGSVRLDASLFEQVLVNIIKNAAEsidsFvgeSGR 359
Cdd:COG2205 78 RLesgkLSLELEPVDLAELLEEAVEELRPLAEEKGIRLELDLPPELPLVYADPELLEQVLANLLDNAIK----Y---SPP 150
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503313842 360 RGEIIIRTVAP---AYIEVIDNGSGISKEVEAKLFSPFF----STKPNGQGIGLVFIREVLIRHNCTFSLRTYNDGLTRF 432
Cdd:COG2205 151 GGTITISARREgdgVRISVSDNGPGIPEEELERIFERFYrgdnSRGEGGTGLGLAIVKRIVEAHGGTIWVESEPGGGTTF 230
|
....
gi 503313842 433 RIMF 436
Cdd:COG2205 231 TVTL 234
|
|
| KinE |
COG5809 |
Sporulation sensor histidine kinase E [Cell cycle control, cell division, chromosome ... |
94-406 |
1.28e-25 |
|
Sporulation sensor histidine kinase E [Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];
Pssm-ID: 444511 [Multi-domain] Cd Length: 489 Bit Score: 108.91 E-value: 1.28e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503313842 94 RMMEQLKNERLRLREQNHFLDLLIQASPMGVVITTLDGEVSQVNPMAVKMLGVRLEEVIDKPLDQVDSPLATELAV---- 169
Cdd:COG5809 124 RDITERKRMEEALRESEEKFRLIFNHSPDGIIVTDLDGRIIYANPAACKLLGISIEELIGKSILELIHSDDQENVAafis 203
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503313842 170 ------IPKDETAVVRLNDANIYKC-THSTFIDRGFKHPFFLI-------ERMTEEVMR-AEKraYEKVIRM---IAHEV 231
Cdd:COG5809 204 qllkdgGIAQGEVRFWTKDGRWRLLeASGAPIKKNGEVDGIVIifrditeRKKLEELLRkSEK--LSVVGELaagIAHEI 281
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503313842 232 NNTTAGITSTLDTVEQALSAEEGMddICDVMRVCTERcfsMSRFITRFADVVKIPEPTLASVRLNDLVAMCKRFMEGMCN 311
Cdd:COG5809 282 RNPLTSLKGFIQLLKDTIDEEQKT--YLDIMLSELDR---IESIISEFLVLAKPQAIKYEPKDLNTLIEEVIPLLQPQAL 356
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503313842 312 DRKISLRLECDPEIGSVRLDASLFEQVLVNIIKNAAESIDSfvgesgrRGEIIIRTVAPAY----IEVIDNGSGISKEVE 387
Cdd:COG5809 357 LKNVQIELELEDDIPDILGDENQLKQVFINLLKNAIEAMPE-------GGNITIETKAEDDdkvvISVTDEGCGIPEERL 429
|
330
....*....|....*....
gi 503313842 388 AKLFSPFFSTKPNGQGIGL 406
Cdd:COG5809 430 KKLGEPFYTTKEKGTGLGL 448
|
|
| KinA |
COG5805 |
Sporulation sensor histidine kinase A (Stage II sporulation protein SpoIIF/SpoIIJ) [Cell cycle ... |
69-436 |
2.59e-22 |
|
Sporulation sensor histidine kinase A (Stage II sporulation protein SpoIIF/SpoIIJ) [Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];
Pssm-ID: 444507 [Multi-domain] Cd Length: 496 Bit Score: 99.04 E-value: 2.59e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503313842 69 REQDFSSRLSQVGQYEADRIVNIFNRMMEQLKNERLrLREQNHFLDLLIQASPMGVVITTLDGEVSQVNPMAVKMLGVRL 148
Cdd:COG5805 116 ELIYVEVKLFPIYNQNGQAAILALRDITKKKKIEEI-LQEQEERLQTLIENSPDLICVIDTDGRILFINESIERLFGAPR 194
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503313842 149 EEVIDKPLDQVDSP--------LATELAVIPKDETAVVRLNDAN----IYKCTHSTFIDRGFKHPFFLI-------ERMT 209
Cdd:COG5805 195 EELIGKNLLELLHPcdkeefkeRIESITEVWQEFIIEREIITKDgrirYFEAVIVPLIDTDGSVKGILVilrditeKKEA 274
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503313842 210 EEVM-RAEKRAYekVIRM---IAHEVNNTTAGITSTLdtveQALSAE-EGMDDICDVMRVCTERcfsMSRFITRFADVVK 284
Cdd:COG5805 275 EELMaRSEKLSI--AGQLaagIAHEIRNPLTSIKGFL----QLLQPGiEDKEEYFDIMLSELDR---IESIISEFLALAK 345
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503313842 285 IPEPTLASVRLNDLVAMCKRFMEGMCNDRKISLRLECDPEIGSVRLDASLFEQVLVNIIKNAAESIdsfvgESGrrGEII 364
Cdd:COG5805 346 PQAVNKEKENINELIQDVVTLLETEAILHNIQIRLELLDEDPFIYCDENQIKQVFINLIKNAIEAM-----PNG--GTIT 418
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 503313842 365 IRTVAP---AYIEVIDNGSGISKEVEAKLFSPFFSTKPNGQGIGLVFIREVLIRHNCTFSLRTYNDGLTRFRIMF 436
Cdd:COG5805 419 IHTEEEdnsVIIRVIDEGIGIPEERLKKLGEPFFTTKEKGTGLGLMVSYKIIENHNGTIDIDSKVGKGTTFTITL 493
|
|
| CitA |
COG3290 |
Sensor histidine kinase DipB regulating citrate/malate metabolism [Signal transduction ... |
31-436 |
7.72e-21 |
|
Sensor histidine kinase DipB regulating citrate/malate metabolism [Signal transduction mechanisms];
Pssm-ID: 442519 [Multi-domain] Cd Length: 389 Bit Score: 93.76 E-value: 7.72e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503313842 31 MHLYIIEGLIAFILLYLIVFYRKIVKPMNTIGCGMELLreqdFSSRLSQVGQYEADRIVNIFNRMMEQLKNERLRLREQN 110
Cdd:COG3290 11 LLILLILILILLLLLLIILLLILLLVLLLLLFLLFVII----LLLLLLILLLILLLLLLLLLAALLLKLLEEIARLVEER 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503313842 111 hflDLLIQASPMGVVITTLDGEVSQVNPMAVKMLGVrleEVIDKPLDQVDSplatelAVIPKDETAVVRLNDANIYKCTH 190
Cdd:COG3290 87 ---EAVLESIREGVIAVDRDGRITLINDAARRLLGL---DAIGRPIDEVLA------EVLETGERDEEILLNGRVLVVNR 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503313842 191 STFIDRGFKHPFFLIERMTEEVMRAEK-----RAYEKVIRMIAHEVNN---TTAGITSTLDTVEqalsAEEGMDDICDVM 262
Cdd:COG3290 155 VPIRDDGRVVGAVATFRDRTELERLEEelegvKELAEALRAQRHDFRNhlhTISGLLQLGEYDE----ALEYIDEISEEL 230
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503313842 263 RVCTERcfsmsrfitrfaDVVKIPEPTLASVrLNDLVAMCKrfmegmcnDRKISLRLECDPEIGSVRLDASLFEQVLVNI 342
Cdd:COG3290 231 QELIDS------------LLSRIGNPVLAAL-LLGKAARAR--------ERGIDLTIDIDSDLPDLPLSDTDLVTILGNL 289
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503313842 343 IKNAAESIDSfVGESGRRGEIIIRTVAPAY-IEVIDNGSGISKEVEAKLFSPFFSTKP-NGQGIGLVFIREVLIRHNCTF 420
Cdd:COG3290 290 LDNAIEAVEK-LPEEERRVELSIRDDGDELvIEVEDSGPGIPEELLEKIFERGFSTKLgEGRGLGLALVKQIVEKYGGTI 368
|
410
....*....|....*.
gi 503313842 421 SLRTYNDGLTRFRIMF 436
Cdd:COG3290 369 EVESEEGEGTVFTVRL 384
|
|
| KinD |
COG5808 |
Sporulation sensor histidine kinase D [Cell cycle control, cell division, chromosome ... |
204-438 |
7.90e-20 |
|
Sporulation sensor histidine kinase D [Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];
Pssm-ID: 444510 [Multi-domain] Cd Length: 454 Bit Score: 91.35 E-value: 7.90e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503313842 204 LIERMTEEVMRAEKRAYEKVIRMIAHEVNNTTAGITSTLDTVEQALSAEEGMDDIcDVMRVCTERcfsMSRFITRFADVV 283
Cdd:COG5808 225 LLERVIQEINTQKLELIGTFAASTAHEIRNPLTSIKGFIQLLQEKYPELEDQKYF-DIIQEEIQR---INQIVSEFLVLG 300
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503313842 284 KIPEPTLASVRLNDLVAMCKRFMEGMCNDRKISLRLECDPEIGSVRLDASLFEQVLVNIIKNAAESIDSfvgesgrRGEI 363
Cdd:COG5808 301 KPTAKKLELDDLNELIEEILSIIDSEANLKNIRVEKQSLDEPLHIKCDKDRIKQVLLNLIKNAIEAMKE-------GGKL 373
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 503313842 364 IIrTVAP----AYIEVIDNGSGISKEVEAKLFSPFFSTKPNGQGIGLVFIREVLIRHNCTFSLRTYNDGLTRFRIMFNA 438
Cdd:COG5808 374 TI-SIENddekAVIEVIDNGEGIPEDIIDEIFEPFVTTKEGGTGLGLSVCKRIVEMHGGEIDIESEEGKGTTFTIRLPL 451
|
|
| HATPase_AtoS-like |
cd16943 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
333-434 |
6.21e-19 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli K-12 AtoS; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs) such as Escherichia coli AtoS, an HK of the AtoS-AtoC TCS. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some have accessory domains such as HAMP or PAS sensor domains or CBS-pair domains.
Pssm-ID: 340419 [Multi-domain] Cd Length: 105 Bit Score: 81.70 E-value: 6.21e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503313842 333 SLFEQVLVNIIKNAAESIDsfvgesgRRGEIIIRT---VAPAYIEVIDNGSGISKEVEAKLFSPFFSTKPNGQ--GIGLV 407
Cdd:cd16943 2 SQLNQVLLNLLVNAAQAME-------GRGRITIRTwahVDQVLIEVEDTGSGIDPEILGRIFDPFFTTKPVGEgtGLGLS 74
|
90 100
....*....|....*....|....*..
gi 503313842 408 FIREVLIRHNCTFSLRTYNDGLTRFRI 434
Cdd:cd16943 75 LSYRIIQKHGGTIRVASVPGGGTRFTI 101
|
|
| WalK |
COG5002 |
Sensor histidine kinase WalK [Signal transduction mechanisms]; |
65-436 |
5.93e-18 |
|
Sensor histidine kinase WalK [Signal transduction mechanisms];
Pssm-ID: 444026 [Multi-domain] Cd Length: 390 Bit Score: 84.99 E-value: 5.93e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503313842 65 MELLREQDFSSRLSQVGQYEADRIVNIFNRMMEQLKNERLRLREQNHFLDLLIQASPMGVVITTLDGEVSQVNPMAVKML 144
Cdd:COG5002 16 LLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLALLLLLLLLLLLLLALLLLLLLLLLLLALALLLLALLLLLLLL 95
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503313842 145 GVRLEEVIDKPLDQVDSPLATELAVIPKDETAVVRLNDANIYKCTHSTFIDRGFKHPFFLIERMTEEVMRAEkrayekVI 224
Cdd:COG5002 96 LLLLALLILLLLLALLILLAALLLLLSELLLLLLLLGRLSLRLSALLLGLLLLAAVERDITELERLEQMRRE------FV 169
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503313842 225 RMIAHEVNNTTAGITSTLDTV-EQALSAEEGMDDICDVMRVCTERcfsMSRFITRFADVVKI----PEPTLASVRLNDLV 299
Cdd:COG5002 170 ANVSHELRTPLTSIRGYLELLlDGAADDPEERREYLEIILEEAER---LSRLVNDLLDLSRLesgeLKLEKEPVDLAELL 246
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503313842 300 AMCKRFMEGMCNDRKISLRLECDPEIGSVRLDASLFEQVLVNIIKNAAESidsfvgeSGRRGEIIIRTVAP---AYIEVI 376
Cdd:COG5002 247 EEVVEELRPLAEEKGIELELDLPEDPLLVLGDPDRLEQVLTNLLDNAIKY-------TPEGGTITVSLREEddqVRISVR 319
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 503313842 377 DNGSGISKEVEAKLFSPFF------STKPNGQGIGLVFIREVLIRHNCTFSLR-TYNDGlTRFRIMF 436
Cdd:COG5002 320 DTGIGIPEEDLPRIFERFYrvdksrSRETGGTGLGLAIVKHIVEAHGGRIWVEsEPGKG-TTFTITL 385
|
|
| PRK10364 |
PRK10364 |
two-component system sensor histidine kinase ZraS; |
202-434 |
7.70e-17 |
|
two-component system sensor histidine kinase ZraS;
Pssm-ID: 236674 [Multi-domain] Cd Length: 457 Bit Score: 82.14 E-value: 7.70e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503313842 202 FFLIERMTE--EVMRAEKRAYEKVIRM------IAHEVNNTTAGITSTLDTVEQALSAEEGMDDICDVMRVCTERcfsMS 273
Cdd:PRK10364 211 FFWYRRYLRsrQLLQDEMKRKEKLVALghlaagVAHEIRNPLSSIKGLAKYFAERAPAGGEAHQLAQVMAKEADR---LN 287
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503313842 274 RFITRFADVVKIPEPTLASVRLNDLVAMCKRFMEGMCNDRKISLRLECDPEIGSVRLDASLFEQVLVNIIKNAAESIDS- 352
Cdd:PRK10364 288 RVVSELLELVKPTHLALQAVDLNDLINHSLQLVSQDANSREIQLRFTANDTLPEIQADPDRLTQVLLNLYLNAIQAIGQh 367
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503313842 353 -----FVGESGRRGEIIIRtvapayieviDNGSGISKEVEAKLFSPFFSTKPNGQGIGLVFIREVLIRHNCTFSLRTYND 427
Cdd:PRK10364 368 gvisvTASESGAGVKISVT----------DSGKGIAADQLEAIFTPYFTTKAEGTGLGLAVVHNIVEQHGGTIQVASQEG 437
|
....*..
gi 503313842 428 GLTRFRI 434
Cdd:PRK10364 438 KGATFTL 444
|
|
| HATPase_TmoS-FixL-DctS-like |
cd16920 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
336-433 |
3.49e-16 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Rhizobium meliloti FixL, and Rhodobacter capsulatus DctS; includes hybrid sensor histidine kinase similar to Pseudomonas mendocina TmoS; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs), such as Pseudomonas mendocina TmoS HK of the TmoS-TmoT TCS, which controls the expression of the toluene-4-monooxygenase pathway, Rhizobium meliloti FixL HK of the FixL-FixJ TCS, which regulates the expression of the genes related to nitrogen fixation in the root nodule in response to O(2) levels, and Rhodobacter capsulatus DctS of the DctS-DctR TCS, which controls synthesis of the high-affinity C4-dicarboxylate transport system. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and PAS sensor domain(s); many are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.
Pssm-ID: 340397 [Multi-domain] Cd Length: 104 Bit Score: 73.97 E-value: 3.49e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503313842 336 EQVLVNIIKNAAESIDsfvGESGRRGEIIIRTV--APAY--IEVIDNGSGISKEVEAKLFSPFFSTKPNGQGIGLVFIRE 411
Cdd:cd16920 2 QQVLINLVRNGIEAMS---EGGCERRELTIRTSpaDDRAvtISVKDTGPGIAEEVAGQLFDPFYTTKSEGLGMGLSICRS 78
|
90 100
....*....|....*....|..
gi 503313842 412 VLIRHNCTFSLRTYNDGLTRFR 433
Cdd:cd16920 79 IIEAHGGRLSVESPAGGGATFQ 100
|
|
| HATPase_Glnl-NtrB-like |
cd16918 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
336-417 |
3.86e-16 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli GlnL (synonyms NtrB and NRII); This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs), similar to Escherichia coli GlnL/NtrB/NRII HK of the two-component regulatory system (TCS) GlnL/GlnG (NtrB-NtrC, or NRII-NRI), which regulates the transcription of genes encoding metabolic enzymes and permeases in response to carbon and nitrogen status in E. coli and related bacteria. Also included in this family are Rhodobacter capsulatus NtrB, Azospirillum brasilense NtrB, Vibrio alginolyticus NtrB, Rhizobium leguminosarum biovar phaseoli NtrB, and Herbaspirillum seropedicae NtrB. Escherichia coli GlnL/NtrB/NRII is both a kinase and a phosphatase, catalyzing the phosphorylation and dephosphorylation of GlnG/NtrC/NRI. The kinase and phosphatase activities of GlnL/NtrB/NRII are regulated by the PII signal transduction protein, which on binding to GlnL/NtrB/NRII, inhibits the kinase activity of GlnL/NtrB/NRII and activates the GlnL/NtrB/NRII phosphatase activity. Proteins having this HATPase domain also have a histidine kinase dimerization and phosphoacceptor domain (HisKA); some also contain PAS sensor domain(s).
Pssm-ID: 340395 [Multi-domain] Cd Length: 109 Bit Score: 73.97 E-value: 3.86e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503313842 336 EQVLVNIIKNAAESIDsfvgesGRRGEIIIRTVA-------------PAYIEVIDNGSGISKEVEAKLFSPFFSTKPNGQ 402
Cdd:cd16918 2 IQVFLNLVRNAAQALA------GSGGEIILRTRTqrqvtlghprhrlALRVSVIDNGPGIPPDLQDTIFYPMVSGRENGT 75
|
90
....*....|....*
gi 503313842 403 GIGLVFIREVLIRHN 417
Cdd:cd16918 76 GLGLAIAQNIVSQHG 90
|
|
| HATPase_c |
smart00387 |
Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases. |
331-436 |
1.59e-14 |
|
Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.
Pssm-ID: 214643 [Multi-domain] Cd Length: 111 Bit Score: 69.60 E-value: 1.59e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503313842 331 DASLFEQVLVNIIKNAAEsidsfvgESGRRGEIIIRTVA---PAYIEVIDNGSGISKEVEAKLFSPFFSTKPN-----GQ 402
Cdd:smart00387 2 DPDRLRQVLSNLLDNAIK-------YTPEGGRITVTLERdgdHVEITVEDNGPGIPPEDLEKIFEPFFRTDKRsrkigGT 74
|
90 100 110
....*....|....*....|....*....|....
gi 503313842 403 GIGLVFIREVLIRHNCTFSLRTYNDGLTRFRIMF 436
Cdd:smart00387 75 GLGLSIVKKLVELHGGEISVESEPGGGTTFTITL 108
|
|
| HATPase_NtrY-like |
cd16944 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
331-436 |
3.78e-14 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Azorhizobium caulinodans NtrY; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs) such as Azorhizobium caulinodans ORS571 NtrY of the NtrY-NtrX TCS, which is involved in nitrogen fixation and metabolism. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and a HAMP sensor domain; some also have PAS sensor domains.
Pssm-ID: 340420 [Multi-domain] Cd Length: 108 Bit Score: 68.33 E-value: 3.78e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503313842 331 DASLFEQVLVNIIKNAAESIDsfvGESGRRGEIIIRTVAPAY----IEVIDNGSGISKEVEAKLFSPFFSTKPNGQGIGL 406
Cdd:cd16944 1 DTTQISQVLTNILKNAAEAIE---GRPSDVGEVRIRVEADQDgrivLIVCDNGKGFPREMRHRATEPYVTTRPKGTGLGL 77
|
90 100 110
....*....|....*....|....*....|
gi 503313842 407 VFIREVLIRHNCTFSLRTYNDGLTRFRIMF 436
Cdd:cd16944 78 AIVKKIMEEHGGRISLSNREAGGACIRIIL 107
|
|
| HATPase_c |
pfam02518 |
Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the ... |
331-436 |
5.46e-13 |
|
Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the structurally related ATPase domains of histidine kinase, DNA gyrase B and HSP90.
Pssm-ID: 460579 [Multi-domain] Cd Length: 109 Bit Score: 65.08 E-value: 5.46e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503313842 331 DASLFEQVLVNIIKNAAEsidsFVGESGRrGEIIIRTVAPAYIEVIDNGSGISKEVEAKLFSPFFS---TKPNGQGIGLV 407
Cdd:pfam02518 2 DELRLRQVLSNLLDNALK----HAAKAGE-ITVTLSEGGELTLTVEDNGIGIPPEDLPRIFEPFSTadkRGGGGTGLGLS 76
|
90 100
....*....|....*....|....*....
gi 503313842 408 FIREVLIRHNCTFSLRTYNDGLTRFRIMF 436
Cdd:pfam02518 77 IVRKLVELLGGTITVESEPGGGTTVTLTL 105
|
|
| glnL |
PRK11073 |
nitrogen regulation protein NR(II); |
106-417 |
2.27e-12 |
|
nitrogen regulation protein NR(II);
Pssm-ID: 182947 [Multi-domain] Cd Length: 348 Bit Score: 67.80 E-value: 2.27e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503313842 106 LREQNHFLDLLIQAspmgvvITTLDGE--VSQVNPMAV--------KMLGVRLEEVIDKP---LDQVDSPLATELAVIPK 172
Cdd:PRK11073 6 LPDAGQILNSLINS------ILLLDDDlaIHYANPAAQqllaqssrKLFGTPLPELLSYFslnIELMRESLQAGQGFTDN 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503313842 173 DETAVVRlNDANIYKCTHSTFIDRgfkhpFFLIE--------RMTEEVMR-AEKRAYEKVIRMIAHEVNNTTAGITSTLD 243
Cdd:PRK11073 80 EVTLVID-GRSHILSLTAQRLPEG-----MILLEmapmdnqrRLSQEQLQhAQQVAARDLVRGLAHEIKNPLGGLRGAAQ 153
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503313842 244 TVEQAL---SAEEGMDDI---CDVMRVCTERCFSMSRFITRFADVV-KIPEptlasvRLNDLVAMckrfmegMCNDrKIS 316
Cdd:PRK11073 154 LLSKALpdpALTEYTKVIieqADRLRNLVDRLLGPQRPGTHVTESIhKVAE------RVVQLVSL-------ELPD-NVR 219
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503313842 317 LRLECDPEIGSVRLDASLFEQVLVNIIKNAAESIdsfvGESGrrGEIIIRT--------------VApAYIEVIDNGSGI 382
Cdd:PRK11073 220 LIRDYDPSLPELAHDPDQIEQVLLNIVRNALQAL----GPEG--GTITLRTrtafqltlhgeryrLA-ARIDIEDNGPGI 292
|
330 340 350
....*....|....*....|....*....|....*
gi 503313842 383 SKEVEAKLFSPFFSTKPNGQGIGLVFIREVLIRHN 417
Cdd:PRK11073 293 PPHLQDTLFYPMVSGREGGTGLGLSIARNLIDQHS 327
|
|
| HATPase_HupT_MifS-like |
cd16976 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
336-434 |
5.83e-11 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Rhodobacter capsulatus HupT and Pseudomonas aeruginosa MifS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Rhodobacter capsulatus HupT of the HupT-HupR two-component regulatory system (TCS), which regulates the synthesis of HupSL, a membrane bound [NiFe]hydrogenase. It also contains the HATPase domain of Pseudomonas aeruginosa MifS, the HK of the MifS-MifR TCS, which may be involved in sensing alpha-ketoglutarate and regulating its transport and subsequent metabolism. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some also have a C-terminal PAS sensor domain.
Pssm-ID: 340435 [Multi-domain] Cd Length: 102 Bit Score: 59.01 E-value: 5.83e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503313842 336 EQVLVNIIKNAAESIDSFvgesgRRGEIII---RTVAPAYIEVIDNGSGISKEVEAKLFSPFFSTKP--NGQGIGLVFIR 410
Cdd:cd16976 2 QQVLMNLLQNALDAMGKV-----ENPRIRIaarRLGGRLVLVVRDNGPGIAEEHLSRVFDPFFTTKPvgKGTGLGLSISY 76
|
90 100
....*....|....*....|....
gi 503313842 411 EVLIRHNCTFSLRTYNDGLTRFRI 434
Cdd:cd16976 77 GIVEEHGGRLSVANEEGAGARFTF 100
|
|
| PRK13557 |
PRK13557 |
histidine kinase; Provisional |
227-406 |
6.84e-11 |
|
histidine kinase; Provisional
Pssm-ID: 237425 [Multi-domain] Cd Length: 540 Bit Score: 63.92 E-value: 6.84e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503313842 227 IAHEVNNTTAGITSTLDTVEQALSAEEG----MDDICDVMRVCTERCFSMSRFITRFADVVKIPEPTlasVRLNDLVA-- 300
Cdd:PRK13557 170 IAHDFNNLLQVMSGYLDVIQAALSHPDAdrgrMARSVENIRAAAERAATLTQQLLAFARKQRLEGRV---LNLNGLVSgm 246
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503313842 301 --MCKRFMEGmcndrKISLRLECDPEIGSVRLDASLFEQVLVNIIKNAAESIDSfvgesgrRGEIIIRT----------- 367
Cdd:PRK13557 247 geLAERTLGD-----AVTIETDLAPDLWNCRIDPTQAEVALLNVLINARDAMPE-------GGRVTIRTrnveiededla 314
|
170 180 190 200
....*....|....*....|....*....|....*....|....*.
gi 503313842 368 ----VAP-AY--IEVIDNGSGISKEVEAKLFSPFFSTKPNGQGIGL 406
Cdd:PRK13557 315 myhgLPPgRYvsIAVTDTGSGMPPEILARVMDPFFTTKEEGKGTGL 360
|
|
| COG4192 |
COG4192 |
Signal transduction histidine kinase regulating phosphoglycerate transport system [Signal ... |
227-417 |
8.74e-11 |
|
Signal transduction histidine kinase regulating phosphoglycerate transport system [Signal transduction mechanisms];
Pssm-ID: 443346 [Multi-domain] Cd Length: 640 Bit Score: 63.94 E-value: 8.74e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503313842 227 IAHEVNNTTAGITSTLDTVEQALSAE--EGMDDICDVMRVCTERcfsMSRFITRFADVVKIPEPTLASVRLNDLVAMCKR 304
Cdd:COG4192 440 LAHELNQPLNAMSMYLFSAKKALEQEnyAQLPTSLDKIEGLIER---MDKIIKSLRQFSRKSDTPLQPVDLRQVIEQAWE 516
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503313842 305 FMEGMCNDRKISLRLECDPEigsVRLDASLFEQVLVNIIKNAAESidsfVGESGRRGEIIIRTVAPAYIEVIDNGSGIsk 384
Cdd:COG4192 517 LVESRAKPQQITLHIPDDLM---VQGDQVLLEQVLVNLLVNALDA----VATQPQISVDLLSNAENLRVAISDNGNGW-- 587
|
170 180 190
....*....|....*....|....*....|...
gi 503313842 385 EVEAKLFSPFFSTKPNGQGIGLVFIREVLIRHN 417
Cdd:COG4192 588 PLVDKLFTPFTTTKEVGLGLGLSICRSIMQQFG 620
|
|
| HATPase_CckA-like |
cd16919 |
Histidine kinase-like ATPase domain of two-component sensor hybrid histidine kinases, similar ... |
335-406 |
2.18e-10 |
|
Histidine kinase-like ATPase domain of two-component sensor hybrid histidine kinases, similar to Brucella abortus 2308 CckA; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component hybrid sensor histidine kinase (HKs) similar to Brucella abortus 2308 CckA, which is a component of an essential protein phosphorelay that regulates expression of genes required for growth, division, and intracellular survival; phosphoryl transfer initiates from the sensor kinase CckA and proceeds via the ChpT phosphotransferase to two regulatory substrates: the DNA-binding response regulator CtrA and the phospho-receiver protein CpdR. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), a REC signal receiver domain, and some contain PAS or PAS and GAF sensor domain(s).
Pssm-ID: 340396 [Multi-domain] Cd Length: 116 Bit Score: 57.77 E-value: 2.18e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503313842 335 FEQVLVNIIKNAAESIdsfvgesGRRGEIIIRT--------VAPAY----------IEVIDNGSGISKEVEAKLFSPFFS 396
Cdd:cd16919 1 LELAILNLAVNARDAM-------PEGGRLTIETsnqrvdadYALNYrdlipgnyvcLEVSDTGSGMPAEVLRRAFEPFFT 73
|
90
....*....|
gi 503313842 397 TKPNGQGIGL 406
Cdd:cd16919 74 TKEVGKGTGL 83
|
|
| PRK13837 |
PRK13837 |
two-component system VirA-like sensor kinase; |
313-434 |
2.58e-10 |
|
two-component system VirA-like sensor kinase;
Pssm-ID: 237526 [Multi-domain] Cd Length: 828 Bit Score: 62.77 E-value: 2.58e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503313842 313 RKISLRLECDPEIGSVRLDASLFEQVLVNIIKNAAES------IDSFVGES-GRRGEIIIRTVAPA--Y--IEVIDNGSG 381
Cdd:PRK13837 539 PGVELDFDQDQEPAVVEGNPAELQQVLMNLCSNAAQAmdgagrVDISLSRAkLRAPKVLSHGVLPPgrYvlLRVSDTGAG 618
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|...
gi 503313842 382 ISKEVEAKLFSPFFSTKPNGQGIGLVFIREVLIRHNCTFSLRTYNDGLTRFRI 434
Cdd:PRK13837 619 IDEAVLPHIFEPFFTTRAGGTGLGLATVHGIVSAHAGYIDVQSTVGRGTRFDV 671
|
|
| KinB |
COG5806 |
Sporulation sensor histidine kinase B [Cell cycle control, cell division, chromosome ... |
306-406 |
1.28e-09 |
|
Sporulation sensor histidine kinase B [Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];
Pssm-ID: 444508 [Multi-domain] Cd Length: 412 Bit Score: 59.88 E-value: 1.28e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503313842 306 MEGMCNDRKISLRLECDPEIgSVRLDASLFEQVLVNIIKNAAESIdsfvgESGrrGEI-IIRTVAPAY--IEVIDNGSGI 382
Cdd:COG5806 284 LSPYANMNNVEIQTELEPGL-YIEGDRQKLQQCLINIIKNGIEAM-----PNG--GTLtIDVSIDKNKviISIKDTGVGM 355
|
90 100
....*....|....*....|....
gi 503313842 383 SKEVEAKLFSPFFSTKPNGQGIGL 406
Cdd:COG5806 356 TKEQLERLGEPYFSTKEKGTGLGT 379
|
|
| COG4251 |
COG4251 |
Bacteriophytochrome (light-regulated signal transduction histidine kinase) [Signal ... |
287-417 |
6.95e-09 |
|
Bacteriophytochrome (light-regulated signal transduction histidine kinase) [Signal transduction mechanisms];
Pssm-ID: 443393 [Multi-domain] Cd Length: 503 Bit Score: 57.87 E-value: 6.95e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503313842 287 EPTLASVRLNDLVAMCKRFMEGMCNDRKISLRLECDPEigsVRLDASLFEQVLVNIIKNAAEsidsFVGEsGRRGEIIIR 366
Cdd:COG4251 350 ELEFEPVDLNELLEEVLEDLEPRIEERGAEIEVGPLPT---VRGDPTLLRQVFQNLISNAIK----YSRP-GEPPRIEIG 421
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*...
gi 503313842 367 TVAPAY---IEVIDNGSGISKEVEAKLFSPFF----STKPNGQGIGLVFIREVLIRHN 417
Cdd:COG4251 422 AEREGGewvFSVRDNGIGIDPEYAEKIFEIFQrlhsRDEYEGTGIGLAIVKKIVERHG 479
|
|
| PAS |
smart00091 |
PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising ... |
111-159 |
6.55e-08 |
|
PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels.
Pssm-ID: 214512 Cd Length: 67 Bit Score: 49.32 E-value: 6.55e-08
10 20 30 40
....*....|....*....|....*....|....*....|....*....
gi 503313842 111 HFLDLLIQASPMGVVITTLDGEVSQVNPMAVKMLGVRLEEVIDKPLDQV 159
Cdd:smart00091 1 ERLRAILESLPDGIFVLDLDGRILYANPAAEELLGYSPEELIGKSLLEL 49
|
|
| PRK11100 |
PRK11100 |
sensory histidine kinase CreC; Provisional |
313-417 |
8.92e-08 |
|
sensory histidine kinase CreC; Provisional
Pssm-ID: 236846 [Multi-domain] Cd Length: 475 Bit Score: 54.08 E-value: 8.92e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503313842 313 RKISLRLECDPeiGSVRLDASLFEQVLVNIIKNAaesIDsFvgeSGRRGEIIIRTVA---PAYIEVIDNGSGISKEVEAK 389
Cdd:PRK11100 349 KGITLRLRPDD--ARVLGDPFLLRQALGNLLDNA---ID-F---SPEGGTITLSAEVdgeQVALSVEDQGPGIPDYALPR 419
|
90 100 110
....*....|....*....|....*....|...
gi 503313842 390 LFSPFFST-KPNGQ----GIGLVFIREVLIRHN 417
Cdd:PRK11100 420 IFERFYSLpRPANGrkstGLGLAFVREVARLHG 452
|
|
| HATPase_CreC-like |
cd16945 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
331-428 |
1.21e-07 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli CreC; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Escherichia coli CreC of the CreC-CreB two-component regulatory system (TCS) involved in catabolic regulation. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), and accessory sensory domain(s) such as HAMP, CACHE or PAS.
Pssm-ID: 340421 [Multi-domain] Cd Length: 106 Bit Score: 49.77 E-value: 1.21e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503313842 331 DASLFEQVLVNIIKNAaesIDsFVGESGrrgEIIIRTVAPA---YIEVIDNGSGISKEVEAKLFSPFFS-TKPNGQ---- 402
Cdd:cd16945 1 DPFLLRQAINNLLDNA---ID-FSPEGG---LIALQLEADTegiELLVFDEGSGIPDYALNRVFERFYSlPRPHSGqkst 73
|
90 100
....*....|....*....|....*.
gi 503313842 403 GIGLVFIREVLIRHNCTFSLRTYNDG 428
Cdd:cd16945 74 GLGLAFVQEVAQLHGGRITLRNRPDG 99
|
|
| PRK10490 |
PRK10490 |
sensor protein KdpD; Provisional |
295-434 |
9.76e-07 |
|
sensor protein KdpD; Provisional
Pssm-ID: 236701 [Multi-domain] Cd Length: 895 Bit Score: 51.19 E-value: 9.76e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503313842 295 LNDLVAMCKRFMEGMCNDRKISLRLEcdPEIGSVRLDASLFEQVLVNIIKNAAESidsfvgeSGRRGEIIIRTVAPA--- 371
Cdd:PRK10490 741 LEEVVGSALQMLEPGLSGHPINLSLP--EPLTLIHVDGPLFERVLINLLENAVKY-------AGAQAEIGIDAHVEGerl 811
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 503313842 372 YIEVIDNGSGISKEVEAKLFSPFF-----STKPnGQGIGLVFIREVLIRHNCTFSLRTYNDGLTRFRI 434
Cdd:PRK10490 812 QLDVWDNGPGIPPGQEQLIFDKFArgnkeSAIP-GVGLGLAICRAIVEVHGGTIWAENRPEGGACFRV 878
|
|
| PRK09303 |
PRK09303 |
histidine kinase; |
207-406 |
1.40e-06 |
|
histidine kinase;
Pssm-ID: 236462 [Multi-domain] Cd Length: 380 Bit Score: 49.95 E-value: 1.40e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503313842 207 RMTEE--VMRAEK-------RAYEKVIRMIAHEVNN--TTAGIT-STLDTVEQALSAEEGMDDICDVMRVCTERCFSMSR 274
Cdd:PRK09303 129 QLSDElfVLRQENetlleqlKFKDRVLAMLAHDLRTplTAASLAlETLELGQIDEDTELKPALIEQLQDQARRQLEEIER 208
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503313842 275 FITRFADVVKIPEPTLasvRLN----DLVAMCKRFMEGMCN---DRKISLRLECDPEIGSVRLDASLFEQVLVNIIKNAA 347
Cdd:PRK09303 209 LITDLLEVGRTRWEAL---RFNpqklDLGSLCQEVILELEKrwlAKSLEIQTDIPSDLPSVYADQERIRQVLLNLLDNAI 285
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 503313842 348 EsidsFVGESgrrGEIII----RTVAPAYIEVIDNGSGISKEVEAKLFSPFF----STKPNGQGIGL 406
Cdd:PRK09303 286 K----YTPEG---GTITLsmlhRTTQKVQVSICDTGPGIPEEEQERIFEDRVrlprDEGTEGYGIGL 345
|
|
| PRK11086 |
PRK11086 |
sensory histidine kinase DcuS; Provisional |
312-411 |
1.59e-06 |
|
sensory histidine kinase DcuS; Provisional
Pssm-ID: 236839 [Multi-domain] Cd Length: 542 Bit Score: 50.30 E-value: 1.59e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503313842 312 DRKISLRLECD---PEIGSVRLDASLFeQVLVNIIKNAAESIDsfvGESGrrGEIiirTVAPAY------IEVIDNGSGI 382
Cdd:PRK11086 409 ELGITLIISEDsqlPDSGDEDQVHELI-TILGNLIENALEAVG---GEEG--GEI---SVSLHYrngwlhCEVSDDGPGI 479
|
90 100
....*....|....*....|....*....
gi 503313842 383 SKEVEAKLFSPFFSTKPNGQGIGLVFIRE 411
Cdd:PRK11086 480 APDEIDAIFDKGYSTKGSNRGVGLYLVKQ 508
|
|
| HATPase_DpiB-CitA-like |
cd16915 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
341-416 |
3.56e-06 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli K-12 DpiB, DcuS, and Bacillus subtilis CitS, DctS, and YufL; This family includes histidine kinase-like ATPase domains of Escherichia coli K-12 DpiB and DcuS, and Bacillus subtilis CitS, DctS and MalK histidine kinases (HKs) all of which are two component transduction systems (TCSs). E. coli K-12 DpiB (also known as CitA) is the histidine kinase (HK) of DpiA-DpiB, a two-component signal transduction system (TCS) required for the expression of citrate-specific fermentation genes and genes involved in plasmid inheritance. E. coli K-12 DcuS (also known as YjdH) is the HK of DcuS-DcuR, a TCS that in the presence of the extracellular C4-dicarboxlates, activates the expression of the genes of anaerobic fumarate respiration and of aerobic C4-dicarboxylate uptake. CitS is the HK of Bacillus subtilis CitS-CitT, a TCS which regulates expression of CitM, the Mg-citrate transporter. Bacillus subtilis DctS forms a tripartite sensor unit (DctS/DctA/DctB) for sensing C4 dicarboxylates. Bacillus subtilis MalK (also known as YfuL) is the HK of MalK-MalR (YufL-YufM) a TCS which regulates the expression of the malate transporters MaeN (YufR) and YflS, and is essential for utilization of malate in minimal medium. Proteins having this DpiB-CitA-like HATPase domain generally have sensor domains such as Cache and PAS, and a histidine kinase A (HisKA)-like SpoOB-type, alpha-helical domain.
Pssm-ID: 340392 [Multi-domain] Cd Length: 104 Bit Score: 45.36 E-value: 3.56e-06
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 503313842 341 NIIKNAAESIDSfVGESGRRGEIIIRTVAPAY-IEVIDNGSGISKEVEAKLFSPFFSTKPNG-QGIGLVFIREVLIRH 416
Cdd:cd16915 7 NLIDNALDALAA-TGAPNKQVEVFLRDEGDDLvIEVRDTGPGIAPELRDKVFERGVSTKGQGeRGIGLALVRQSVERL 83
|
|
| HATPase_EvgS-ArcB-TorS-like |
cd16922 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases, many are hybrid ... |
335-411 |
1.07e-05 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases, many are hybrid sensor histidine kinases, similar to Escherichia coli EvgS, ArcB, TorS, BarA, RcsC; This family contains the histidine kinase-like ATPase (HATPase) domains of various two-component hybrid sensor histidine kinases (HKs), including the following Escherichia coli HKs: EvgS, a HK of the EvgS-EvgA two-component system (TCS) that confers acid resistance; ArcB, a HK of the ArcB-ArcA TCS that modulates the expression of numerous genes in response to respiratory growth conditions; TorS, a HK of the TorS-TorR TCS which is involved in the anaerobic utilization of trimethylamine-N-oxide; BarA, a HK of the BarA-UvrY TCS involved in the regulation of carbon metabolism; and RcsC, a HK of the RcsB-RcsC TCS which regulates the expression of the capsule operon and of the cell division gene ftsZ. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), with most having accessory sensor domain(s) such as GAF, PAS and CHASE; many are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.
Pssm-ID: 340399 [Multi-domain] Cd Length: 110 Bit Score: 44.02 E-value: 1.07e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503313842 335 FEQVLVNIIKNAAEsidsFVgesgRRGEIIIR--------TVAPAYIEVIDNGSGISKEVEAKLFSPF------FSTKPN 400
Cdd:cd16922 1 LRQILLNLLGNAIK----FT----EEGEVTLRvsleeeeeDGVQLRFSVEDTGIGIPEEQQARLFEPFsqadssTTRKYG 72
|
90
....*....|.
gi 503313842 401 GQGIGLVFIRE 411
Cdd:cd16922 73 GTGLGLAISKK 83
|
|
| RocR |
COG3829 |
RocR-type transcriptional regulator, contains PAS, AAA-type ATPase, and DNA-binding Fis ... |
102-159 |
1.12e-05 |
|
RocR-type transcriptional regulator, contains PAS, AAA-type ATPase, and DNA-binding Fis domains [Transcription, Signal transduction mechanisms];
Pssm-ID: 443041 [Multi-domain] Cd Length: 448 Bit Score: 47.46 E-value: 1.12e-05
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....*...
gi 503313842 102 ERLRLREQNHFLDLLIQASPMGVVITTLDGEVSQVNPMAVKMLGVRLEEVIDKPLDQV 159
Cdd:COG3829 2 EELELKELEEELEAILDSLDDGIIVVDADGRITYVNRAAERILGLPREEVIGKNVTEL 59
|
|
| HATPase_EnvZ-like |
cd16950 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
337-434 |
1.28e-05 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli EnvZ and Pseudomonas aeruginosa BfmS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Escherichia coli EnvZ of the EnvZ-OmpR two-component regulatory system (TCS), which functions in osmoregulation. It also contains the HATPase domain of Pseudomonas aeruginosa BfmS, the HK of the BfmSR TCS, which functions in the regulation of the rhl quorum-sensing system and bacterial virulence in P. aeruginosa. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and a HAMP sensor domain; some also contain a periplasmic domain.
Pssm-ID: 340426 [Multi-domain] Cd Length: 101 Bit Score: 43.98 E-value: 1.28e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503313842 337 QVLVNIIKNAAESidsfvgesgRRGEIIIRT-VAPAY--IEVIDNGSGISKEVEAKLFSPFF----STKPNGQGIGLVFI 409
Cdd:cd16950 3 RVLSNLVDNALRY---------GGGWVEVSSdGEGNRtrIQVLDNGPGIAPEEVDELFQPFYrgdnARGTSGTGLGLAIV 73
|
90 100
....*....|....*....|....*
gi 503313842 410 REVLIRHNCTFSLRTYNDGLTRFRI 434
Cdd:cd16950 74 QRISDAHGGSLTLANRAGGGLCARI 98
|
|
| PAS |
COG2202 |
PAS domain [Signal transduction mechanisms]; |
102-162 |
1.56e-05 |
|
PAS domain [Signal transduction mechanisms];
Pssm-ID: 441804 [Multi-domain] Cd Length: 258 Bit Score: 46.17 E-value: 1.56e-05
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 503313842 102 ERLRLREQNHFLDLLIQASPMGVVITTLDGEVSQVNPMAVKMLGVRLEEVIDKPLDQVDSP 162
Cdd:COG2202 2 AEEALEESERRLRALVESSPDAIIITDLDGRILYVNPAFERLTGYSAEELLGKTLRDLLPP 62
|
|
| PAS |
COG2202 |
PAS domain [Signal transduction mechanisms]; |
97-168 |
2.87e-05 |
|
PAS domain [Signal transduction mechanisms];
Pssm-ID: 441804 [Multi-domain] Cd Length: 258 Bit Score: 45.40 E-value: 2.87e-05
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 503313842 97 EQLKNERlRLREQNHFLDLLIQASPMGVVITTLDGEVSQVNPMAVKMLGVRLEEVIDKPLDQVDSPLATELA 168
Cdd:COG2202 124 ERKRAEE-ALRESEERLRLLVENAPDGIFVLDLDGRILYVNPAAEELLGYSPEELLGKSLLDLLHPEDRERL 194
|
|
| PRK11466 |
PRK11466 |
hybrid sensory histidine kinase TorS; Provisional |
215-410 |
3.34e-05 |
|
hybrid sensory histidine kinase TorS; Provisional
Pssm-ID: 236914 [Multi-domain] Cd Length: 914 Bit Score: 46.44 E-value: 3.34e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503313842 215 AEK--RAYEKVIRMIAHEVNNTTAGITSTLdtveQALSAEEGMDDICDVMRVCTERCFSMSRFITRFADVVKIpEPTLAS 292
Cdd:PRK11466 437 AEKasQAKSAFLAAMSHEIRTPLYGILGTA----QLLADNPALNAQRDDLRAITDSGESLLTILNDILDYSAI-EAGGKN 511
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503313842 293 VRLND-------LVAMCKRFMEGMCNDRKISLRLECDPEIGS-VRLDASLFEQVLVNIIKNAAESIDsfvgesgrRGEII 364
Cdd:PRK11466 512 VSVSDepfeprpLLESTLQLMSGRVKGRPIRLATDIADDLPTaLMGDPRRIRQVITNLLSNALRFTD--------EGSIV 583
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|.
gi 503313842 365 IRTVAPA---YIEVIDNGSGISKEVEAKLFSPF--FSTKPNGQGIGLVFIR 410
Cdd:PRK11466 584 LRSRTDGeqwLVEVEDSGCGIDPAKLAEIFQPFvqVSGKRGGTGLGLTISS 634
|
|
| PAS |
pfam00989 |
PAS fold; The PAS fold corresponds to the structural domain that has previously been defined ... |
112-156 |
5.34e-05 |
|
PAS fold; The PAS fold corresponds to the structural domain that has previously been defined as PAS and PAC motifs. The PAS fold appears in archaea, eubacteria and eukarya. This domain can bind gases (O2, CO and NO), FAD, 4-hydroxycinnamic acid and NAD+ (Matilla et.al., FEMS Microbiology Reviews, fuab043, 45, 2021, 1. https://doi.org/10.1093/femsre/fuab043).
Pssm-ID: 395786 [Multi-domain] Cd Length: 113 Bit Score: 42.40 E-value: 5.34e-05
10 20 30 40
....*....|....*....|....*....|....*....|....*
gi 503313842 112 FLDLLIQASPMGVVITTLDGEVSQVNPMAVKMLGVRLEEVIDKPL 156
Cdd:pfam00989 2 DLRAILESLPDGIFVVDEDGRILYVNAAAEELLGLSREEVIGKSL 46
|
|
| YesM |
COG2972 |
Sensor histidine kinase YesM [Signal transduction mechanisms]; |
293-434 |
7.44e-05 |
|
Sensor histidine kinase YesM [Signal transduction mechanisms];
Pssm-ID: 442211 [Multi-domain] Cd Length: 445 Bit Score: 45.01 E-value: 7.44e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503313842 293 VRLNDLVAMCKRFM--EGMCNDRKISLRLECDPEIGSVRlDASLFEQVLV-NIIKNAAESidsfvgeSGRRGEIIIRTVA 369
Cdd:COG2972 297 VTLEEELELIKSYLeiQKLRFGDRLEVEIEIDEELLDLL-IPKLILQPLVeNAIEHGIEP-------KEGGGTIRISIRK 368
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 503313842 370 PA---YIEVIDNGSGISKEVEAKLFSPfFSTKPNGQGIGLVFIREVLIRH---NCTFSLRTYNDGLTRFRI 434
Cdd:COG2972 369 EGdrlVITVEDNGVGMPEEKLEKLLEE-LSSKGEGRGIGLRNVRERLKLYygeEYGLEIESEPGEGTTVTI 438
|
|
| NarQ |
COG3850 |
Signal transduction histidine kinase NarQ, nitrate/nitrite-specific [Signal transduction ... |
29-258 |
1.26e-04 |
|
Signal transduction histidine kinase NarQ, nitrate/nitrite-specific [Signal transduction mechanisms];
Pssm-ID: 443059 [Multi-domain] Cd Length: 448 Bit Score: 44.10 E-value: 1.26e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503313842 29 HFMHLYIIEGLIAFILLYLIVFYRKIVKPMNTIGCGMELLREQDFSSRLSQVGQYEADRIVNIFNRMMEQLKNERLRLRE 108
Cdd:COG3850 117 RKLALLRLLLALLLALLLAYLLRRRIVRPLRRLTQAAERIARGDFDARVPVSGRDELGTLARAFNRMADELQELYAELEE 196
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503313842 109 QNHFLDLLIQASPMGVVITTLDGEVSQVNPMAVKMLGVRLEEVIDKPLDQ----VDSPLATELAVIPKDETAVVRLNDAN 184
Cdd:COG3850 197 EEELEAELELLALLDELLLLAALLLLLALLLALLLAALLAALLLLLLLQDalaeSELLALNILAGLLELLLALLLLLLAS 276
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 503313842 185 IYKCTHSTFIDRGFKHPFFLIERMTEEVMRAEKRAYEKVIRMIAHEVNNTTAGITSTLDTVEQALSAEEGMDDI 258
Cdd:COG3850 277 ALLLLELELLALLLELVELLALAAAEEALLLLVELAALLLLLLLQAIANASLLLIALASVVAALLELASILALQ 350
|
|
| PAS |
cd00130 |
PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising ... |
120-159 |
1.28e-04 |
|
PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in signal transduction.
Pssm-ID: 238075 [Multi-domain] Cd Length: 103 Bit Score: 41.08 E-value: 1.28e-04
10 20 30 40
....*....|....*....|....*....|....*....|
gi 503313842 120 SPMGVVITTLDGEVSQVNPMAVKMLGVRLEEVIDKPLDQV 159
Cdd:cd00130 1 LPDGVIVLDLDGRILYANPAAEQLLGYSPEELIGKSLLDL 40
|
|
| PRK09959 |
PRK09959 |
acid-sensing system histidine kinase EvgS; |
316-434 |
1.55e-04 |
|
acid-sensing system histidine kinase EvgS;
Pssm-ID: 182169 [Multi-domain] Cd Length: 1197 Bit Score: 44.34 E-value: 1.55e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503313842 316 SLRLECD---PEIGSVRLDASLFEQVLVNIIKNAAEsidsFVGEsgrrGEIIIRTV--------APAYIEVIDNGSGISK 384
Cdd:PRK09959 807 SIALSCSstfPDHYLVKIDPQAFKQVLSNLLSNALK----FTTE----GAVKITTSlghiddnhAVIKMTIMDSGSGLSQ 878
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....
gi 503313842 385 EVEAKLFSPFFST----KPNGQGIGLVFIREVLIRHNCTFSLRTYNDGLTRFRI 434
Cdd:PRK09959 879 EEQQQLFKRYSQTsagrQQTGSGLGLMICKELIKNMQGDLSLESHPGIGTTFTI 932
|
|
| PRK13560 |
PRK13560 |
hypothetical protein; Provisional |
106-167 |
5.38e-04 |
|
hypothetical protein; Provisional
Pssm-ID: 106506 [Multi-domain] Cd Length: 807 Bit Score: 42.35 E-value: 5.38e-04
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 503313842 106 LREQNHFLDLLIQASPMGVVITTLDGEVSQV-NPMAVKMLGVRLEEVIDKPLDQVDSPLATEL 167
Cdd:PRK13560 327 LLEKEDMLRAIIEAAPIAAIGLDADGNICFVnNNAAERMLGWSAAEVMGKPLPGMDPELNEEF 389
|
|
| Tar |
COG0840 |
Methyl-accepting chemotaxis protein (MCP) [Signal transduction mechanisms]; |
35-101 |
1.01e-03 |
|
Methyl-accepting chemotaxis protein (MCP) [Signal transduction mechanisms];
Pssm-ID: 440602 [Multi-domain] Cd Length: 533 Bit Score: 41.54 E-value: 1.01e-03
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 503313842 35 IIEGLIAFILLYLIVFYRKIVKPMNTIGCGMELLREQDFSSRLSQVGQYEADRIVNIFNRMMEQLKN 101
Cdd:COG0840 187 ALLALVALAIILALLLSRSITRPLRELLEVLERIAEGDLTVRIDVDSKDEIGQLADAFNRMIENLRE 253
|
|
| PRK15347 |
PRK15347 |
two component system sensor kinase; |
307-406 |
2.93e-03 |
|
two component system sensor kinase;
Pssm-ID: 237951 [Multi-domain] Cd Length: 921 Bit Score: 40.01 E-value: 2.93e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503313842 307 EGMCNDRKISLRLECDPEIG-SVRLDASLFEQVLVNIIKNAAESIDSfvgesgrrGEIIIRTVAPA---YIEVIDNGSGI 382
Cdd:PRK15347 485 QGPAQSKSLTLRTFVGAHVPlYLHLDSLRLRQILVNLLGNAVKFTET--------GGIRLRVKRHEqqlCFTVEDTGCGI 556
|
90 100
....*....|....*....|....
gi 503313842 383 SKEVEAKLFSPFFSTKPNGQGIGL 406
Cdd:PRK15347 557 DIQQQQQIFTPFYQADTHSQGTGL 580
|
|
| HATPase_RstB-like |
cd16939 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
336-434 |
3.72e-03 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Salmonella typhimurium RstB; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Salmonella typhimurium RstB HK of the RstA-RstB two-component regulatory system (TCS), which regulates expression of the constituents participating in pyrimidine metabolism and iron acquisition, and may be required for regulation of Salmonella motility and invasion. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), and a HAMP sensor domain.
Pssm-ID: 340416 [Multi-domain] Cd Length: 104 Bit Score: 37.02 E-value: 3.72e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503313842 336 EQVLVNIIKNAAESIDSFVGESGR-RGEiiirtvaPAYIEVIDNGSGISKEVEAKLFSPFFSTKPN------GQGIGLVF 408
Cdd:cd16939 2 ARALDNLLRNALRYAHRTVRIALLvSGG-------RLTLIVEDDGPGIPAAARERVFEPFVRLDPSrdratgGFGLGLAI 74
|
90 100
....*....|....*....|....*.
gi 503313842 409 IREVLIRHNCTFSLRTYNDGLTRFRI 434
Cdd:cd16939 75 VHRVALWHGGHVECDDSELGGACFRL 100
|
|
| COG3920 |
COG3920 |
Two-component sensor histidine kinase, HisKA and HATPase domains [Signal transduction ... |
25-436 |
4.00e-03 |
|
Two-component sensor histidine kinase, HisKA and HATPase domains [Signal transduction mechanisms];
Pssm-ID: 443125 [Multi-domain] Cd Length: 495 Bit Score: 39.50 E-value: 4.00e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503313842 25 VDKIHFMHLYIIEGLIAFILLYLIVFYRKIVKPMNTIGCGMELLREQDFSSRLSQVGQYEADRIVNIFNRMMEQLKNERL 104
Cdd:COG3920 81 LLALLVLLLLLLLAAAALALALLLAALAGLLLLAALLLLRLVALLAALALLALLLLLLLLLAILALAELAVALAELAAAL 160
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503313842 105 RLREQNHFLDLLIQASPMGVVITTLDGEVSQVNPMAVKMLGVRLEEVIDKPLDQVDSPLATELAVIPKDETAVVRLNDAN 184
Cdd:COG3920 161 LLLAEELAALRLAAAALLLLLAALLDLGLALAALAAAALLALLLALELLLALLLLLLLLLALLLVLLAALLRLRAAVLEE 240
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503313842 185 IYKC-------------THSTFIDRGFKHPFFLIERMTEEVMRAEKRAYEKV------IRMIAHEVNNTTAGITSTLDTv 245
Cdd:COG3920 241 LERRrrarglgrlllllLLLLLLLRALLLLAAGIRLVITERKRAEEELEASLeekellLRELHHRVKNNLQVVSSLLRL- 319
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503313842 246 eQALSAEEgmDDICDVMRVCTERCFSMSRFITRFADvvkipEPTLASVRLNDLVAMCKRFMEGMCNDRKISLRLECDPei 325
Cdd:COG3920 320 -QARRADD--PEAREALEESQNRIQALALVHELLYQ-----SEDWEGVDLRDYLRELLEPLRDSYGGRGIRIELDGPD-- 389
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503313842 326 gsVRLDAS--------LFEqVLVNIIKNAAESidsfvgesGRRGEIIIR-TVAP--AYIEVIDNGSGISKEVEAklfspf 394
Cdd:COG3920 390 --VELPADaavplgliLNE-LVTNALKHAFLS--------GEGGRIRVSwRREDgrLRLTVSDNGVGLPEDVDP------ 452
|
410 420 430 440
....*....|....*....|....*....|....*....|..
gi 503313842 395 fstkPNGQGIGLVFIREVLIRHNCTFSLRTyNDGlTRFRIMF 436
Cdd:COG3920 453 ----PARKGLGLRLIRALVRQLGGTLELDR-PEG-TRVRITF 488
|
|
| HATPase_EcPhoR-like |
cd16952 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
341-436 |
4.30e-03 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli PhoR; This family includes histidine kinase-like ATPase (HATPase) domain of two-component sensor histidine kinases similar to Escherichia coli or Vibrio cholera PhoR, the histidine kinase (HK) of PhoB-PhoR a two-component signal transduction system (TCS) involved in phosphate regulation. PhoR monitors extracellular inorganic phosphate (Pi) availability and PhoB, the response regulator, regulates transcription of genes of the phosphate regulon. PhoR is a bifunctional histidine autokinase/phospho-PhoB phosphatase; in phosphate deficiency, it autophosphorylates and Pi is transferred to PhoB, and when environmental Pi is abundant, it removes the phosphoryl group from phosphorylated PhoB. Other roles of PhoB-PhoR TCS have been described, including motility, biofilm formation, intestinal colonization, and virulence in V. cholera. E.coli PhoR and Bacillus subtilis PhoR (whose HATPase domain belongs to a different family) sense very different signals in each bacterium. In E. coli the PhoR signal comes from phosphate transport mediated by the PstSCAB2 phosphate transporter and the PhoU chaperone-like protein while in B. subtilis, the PhoR activation signal comes from wall teichoic acid (WTA) metabolism.
Pssm-ID: 340428 [Multi-domain] Cd Length: 108 Bit Score: 36.80 E-value: 4.30e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503313842 341 NIIKNAaesidsfVGESGRRGEIIIRTVAP---AYIEVIDNGSGISKEVEAKLFSPFF------STKPNGQGIGLVFIRE 411
Cdd:cd16952 7 NLVSNA-------VKYTPPSDTITVRWSQEesgARLSVEDTGPGIPPEHIPRLTERFYrvdierCRNTGGTGLGLAIVKH 79
|
90 100
....*....|....*....|....*
gi 503313842 412 VLIRHNCTFSLRTYNDGLTRFRIMF 436
Cdd:cd16952 80 VMSRHDARLLIASELGKGSRFTCLF 104
|
|
| HAMP |
pfam00672 |
HAMP domain; |
49-101 |
4.79e-03 |
|
HAMP domain;
Pssm-ID: 459898 [Multi-domain] Cd Length: 53 Bit Score: 34.91 E-value: 4.79e-03
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|...
gi 503313842 49 VFYRKIVKPMNTIGCGMELLREQDFSSRLSQVGQYEADRIVNIFNRMMEQLKN 101
Cdd:pfam00672 1 LLARRILRPLRRLAEAARRIASGDLDVRLPVSGRDEIGELARAFNQMAERLRE 53
|
|
| PAS_8 |
pfam13188 |
PAS domain; PAS domains are involved in many signalling proteins where they are used as a ... |
112-166 |
6.67e-03 |
|
PAS domain; PAS domains are involved in many signalling proteins where they are used as a signal sensor domain. PAS domains appear in archaea, bacteria and eukaryotes. Several PAS-domain proteins are known to detect their signal by way of an associated cofactor. Heme, flavin, and a 4-hydroxycinnamyl chromophore are used in different proteins. This domain recognizes oxygen and CO (Matilla et al., FEMS Microbiology Reviews, fuab043, 45, 2021, 1. https://doi.org/10.1093/femsre/fuab043).
Pssm-ID: 463802 [Multi-domain] Cd Length: 65 Bit Score: 35.22 E-value: 6.67e-03
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....*
gi 503313842 112 FLDLLIQASPMGVVITTLDGEVSQVNPMAVKMLGVRLEEVIDKPLDQVDSPLATE 166
Cdd:pfam13188 2 RLRALFESSPDGILVLDEGGRIIYVNPAALELLGYELLGELLGELLDLLDPLLED 56
|
|
| HAMP |
smart00304 |
HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain; |
52-100 |
7.21e-03 |
|
HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain;
Pssm-ID: 197640 [Multi-domain] Cd Length: 53 Bit Score: 34.53 E-value: 7.21e-03
10 20 30 40
....*....|....*....|....*....|....*....|....*....
gi 503313842 52 RKIVKPMNTIGCGMELLREQDFSSRLSQVGQYEADRIVNIFNRMMEQLK 100
Cdd:smart00304 1 RRLLRPLRRLAEAAQRIADGDLTVRLPVDGRDEIGELARAFNEMADRLE 49
|
|
| envZ |
PRK09467 |
osmolarity sensor protein; Provisional |
312-436 |
8.98e-03 |
|
osmolarity sensor protein; Provisional
Pssm-ID: 236531 [Multi-domain] Cd Length: 435 Bit Score: 38.35 E-value: 8.98e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503313842 312 DRKISLRLEcdPEIGSVRLDASLFEQVLVNIIKNAA----ESIDSFVGESGRRgeiiirtvapAYIEVIDNGSGISKEVE 387
Cdd:PRK09467 311 EREIETALQ--PGPIEVPMNPIAIKRALANLVVNAArygnGWIKVSSGTEGKR----------AWFQVEDDGPGIPPEQL 378
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*
gi 503313842 388 AKLFSPFfsTKPN------GQGIGLVFIREVLIRHNCTFSLRTYNDGLTRFRIMF 436
Cdd:PRK09467 379 KHLFQPF--TRGDsargssGTGLGLAIVKRIVDQHNGKVELGNSEEGGLSARAWL 431
|
|
| HATPase_BceS-YxdK-YvcQ-like |
cd16948 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
335-437 |
9.11e-03 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Bacillus subtilis BceS, YxdK, and Bacillus thuringiensis YvcQ; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Bacillus subtilis BceS and Bacillus thuringiensis YvcQ, the HKs of the two-component regulatory system (TCSs) BceS-BceR and YvcQ-YvcP, repsectively, which are both involved in regulating bacitracin resistance. It also includes the HATPase domain of YxdK, the HK of YxdK-YxdJ TCS involved in sensing antimicrobial compounds.
Pssm-ID: 340424 [Multi-domain] Cd Length: 109 Bit Score: 35.72 E-value: 9.11e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503313842 335 FEQVLVNIIKNAAES----IDSFVGESGRRgeiiirtvapayIEVIDNGSGISKEVEAKLFSPFFsTKPNGQ------GI 404
Cdd:cd16948 10 IGQIVSNALKYSKQGgkieIYSETNEQGVV------------LSIKDFGIGIPEEDLPRVFDKGF-TGENGRnfqestGM 76
|
90 100 110
....*....|....*....|....*....|...
gi 503313842 405 GLVFIREVLIRHNCTFSLRTYNDGLTRFRIMFN 437
Cdd:cd16948 77 GLYLVKKLCDKLGHKIDVESEVGEGTTFTITFP 109
|
|
| HATPase_VanS-like |
cd16923 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
335-435 |
9.38e-03 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Enterococcus faecium VanS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Enterococcus faecium VanS HK of the VanS-VanR two-component regulatory system (TCS) which activates the transcription of vanH, vanA and vanX vancomycin resistance genes. It also contains Ecoli YedV and PcoS, probable members of YedW-YedV TCS and PcoS-PcoR TCS, repectively. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); most also have a HAMP sensor domain.
Pssm-ID: 340400 [Multi-domain] Cd Length: 102 Bit Score: 35.83 E-value: 9.38e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503313842 335 FEQVLVNIIK----NAAESIDSFVgesgrRGEIIIrtvapayIEVIDNGSGISKEVEAKLFSPFF----STKPNGQGIGL 406
Cdd:cd16923 5 FSNLLSNAIKyspeNTRIYITSFL-----TDDVVN-------IMFKNPSSHPLDFKLEKLFERFYrgdnSRNTEGAGLGL 72
|
90 100
....*....|....*....|....*....
gi 503313842 407 VFIREVLIRHNCTFSLRtYNDGLTRFRIM 435
Cdd:cd16923 73 SIAKAIIELHGGSASAE-YDDNHDLFKVR 100
|
|
| |
