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Conserved domains on  [gi|503348417|ref|WP_013583078|]
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MULTISPECIES: type II toxin-antitoxin system RelE/ParE family toxin [Enterobacterales]

Protein Classification

type II toxin-antitoxin system RelE/ParE family toxin( domain architecture ID 10007661)

type II toxin-antitoxin system RelE/ParE family toxin similar to Haemophilus influenzae protein HI_1419

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
COG3657 COG3657
Putative component of the toxin-antitoxin plasmid stabilization module [Defense mechanisms];
1-96 1.72e-56

Putative component of the toxin-antitoxin plasmid stabilization module [Defense mechanisms];


:

Pssm-ID: 442874  Cd Length: 103  Bit Score: 169.57  E-value: 1.72e-56
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503348417   1 MIEIKRTPEVEKWLRSLKDRTAKAKILMRLERMEDGNFGDVEPIGDGLSELRIHQGKGYRVYFGNKNNQIILLLCGGDKS 80
Cdd:COG3657    3 YYTIDGTEPFDEWLASLKDRRARARILARLDRLELGNFGDVKPVGEGVSELRIDFGPGYRVYYAQRGDVLVLLLCGGDKS 82

                         90
                 ....*....|....*.
gi 503348417  81 TQQADIRKAKQLAKQW 96
Cdd:COG3657   83 TQQKDIKKAKELAKEY 98
 
Name Accession Description Interval E-value
COG3657 COG3657
Putative component of the toxin-antitoxin plasmid stabilization module [Defense mechanisms];
1-96 1.72e-56

Putative component of the toxin-antitoxin plasmid stabilization module [Defense mechanisms];


Pssm-ID: 442874  Cd Length: 103  Bit Score: 169.57  E-value: 1.72e-56
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503348417   1 MIEIKRTPEVEKWLRSLKDRTAKAKILMRLERMEDGNFGDVEPIGDGLSELRIHQGKGYRVYFGNKNNQIILLLCGGDKS 80
Cdd:COG3657    3 YYTIDGTEPFDEWLASLKDRRARARILARLDRLELGNFGDVKPVGEGVSELRIDFGPGYRVYYAQRGDVLVLLLCGGDKS 82

                         90
                 ....*....|....*.
gi 503348417  81 TQQADIRKAKQLAKQW 96
Cdd:COG3657   83 TQQKDIKKAKELAKEY 98
upstrm_HI1419 TIGR02683
putative addiction module killer protein; Members of this strictly bacterial protein family ...
 2-96 7.77e-50

putative addiction module killer protein; Members of this strictly bacterial protein family are small, at roughly 100 amino acids. The gene is almost invariably the upstream member of a gene pair, where the downstream member is a predicted DNA-binding protein from a clade within Pfam helix-turn-helix family pfam01381. These gene pairs, when found on the bacterial chromosome, often are located with prophage regions, but also in both integrated plasmid regions and near housekeeping genes. Analysis suggests that the gene pair may serve as an addiction module.


Pssm-ID: 162974  Cd Length: 95  Bit Score: 152.36  E-value: 7.77e-50
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503348417   2 IEIKRTPEVEKWLRSLKDRTAKAKILMRLERMEDGNFGDVEPIGDGLSELRIHQGKGYRVYFGNKNNQIILLLCGGDKST 81
Cdd:TIGR02683  1 YTIDRTDTFDKWLDGLKDPRAKARILARIDRLALGNFGDVKPVGEGVSELRIDFGPGYRVYFTQRGKVIILLLCGGDKST 80

                         90
                 ....*....|....*
gi 503348417  82 QQADIRKAKQLAKQW 96
Cdd:TIGR02683 81 QQKDIKRAKELAKDL 95
Gp49 pfam05973
Phage derived protein Gp49-like (DUF891); This family consists of hypothetical bacterial ...
 12-94 2.63e-11

Phage derived protein Gp49-like (DUF891); This family consists of hypothetical bacterial proteins of unknown function as well as phage Gp49 proteins.


Pssm-ID: 461791  Cd Length: 90  Bit Score: 54.51  E-value: 2.63e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503348417  12 KWLRSLkDRTAKAKILMRLERMEDGNFGDVEP----IGDGLSELRIHQGKG-YRV-YFGNKNNQIILLlCGGDKSTQQ-- 83
Cdd:pfam05973  1 DELDAL-PDKVRAKFLAALDLLEEGGPDLGKPlvkkLGGGLWELRVRDAGGiYRVlYAFDPGRAVYVL-HAFQKKTQKtp 78

                         90
                 ....*....|..
gi 503348417  84 -ADIRKAKQLAK 94
Cdd:pfam05973 79 kKEIDLAERRLK 90
 
Name Accession Description Interval E-value
COG3657 COG3657
Putative component of the toxin-antitoxin plasmid stabilization module [Defense mechanisms];
1-96 1.72e-56

Putative component of the toxin-antitoxin plasmid stabilization module [Defense mechanisms];


Pssm-ID: 442874  Cd Length: 103  Bit Score: 169.57  E-value: 1.72e-56
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503348417   1 MIEIKRTPEVEKWLRSLKDRTAKAKILMRLERMEDGNFGDVEPIGDGLSELRIHQGKGYRVYFGNKNNQIILLLCGGDKS 80
Cdd:COG3657    3 YYTIDGTEPFDEWLASLKDRRARARILARLDRLELGNFGDVKPVGEGVSELRIDFGPGYRVYYAQRGDVLVLLLCGGDKS 82

                         90
                 ....*....|....*.
gi 503348417  81 TQQADIRKAKQLAKQW 96
Cdd:COG3657   83 TQQKDIKKAKELAKEY 98
upstrm_HI1419 TIGR02683
putative addiction module killer protein; Members of this strictly bacterial protein family ...
 2-96 7.77e-50

putative addiction module killer protein; Members of this strictly bacterial protein family are small, at roughly 100 amino acids. The gene is almost invariably the upstream member of a gene pair, where the downstream member is a predicted DNA-binding protein from a clade within Pfam helix-turn-helix family pfam01381. These gene pairs, when found on the bacterial chromosome, often are located with prophage regions, but also in both integrated plasmid regions and near housekeeping genes. Analysis suggests that the gene pair may serve as an addiction module.


Pssm-ID: 162974  Cd Length: 95  Bit Score: 152.36  E-value: 7.77e-50
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503348417   2 IEIKRTPEVEKWLRSLKDRTAKAKILMRLERMEDGNFGDVEPIGDGLSELRIHQGKGYRVYFGNKNNQIILLLCGGDKST 81
Cdd:TIGR02683  1 YTIDRTDTFDKWLDGLKDPRAKARILARIDRLALGNFGDVKPVGEGVSELRIDFGPGYRVYFTQRGKVIILLLCGGDKST 80

                         90
                 ....*....|....*
gi 503348417  82 QQADIRKAKQLAKQW 96
Cdd:TIGR02683 81 QQKDIKRAKELAKDL 95
COG4679 COG4679
Phage-related protein [Mobilome: prophages, transposons];
1-96 1.19e-12

Phage-related protein [Mobilome: prophages, transposons];


Pssm-ID: 443715  Cd Length: 113  Bit Score: 58.71  E-value: 1.19e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503348417   1 MIEIKRTPEVEKWLRSLkDRTAKAKILMRLERMEDGNFGDVEP----IGDGLSELRIHQGKG-YRV-YFGNKNNQIILLL 74
Cdd:COG4679    5 VEFYGTKEPVLDFLLAL-PAKVRAKIGRALDLLQEGGPDLGKPltkgLGDGLFELRIKGGSGiYRVlYFAKFGDAVVVLH 83

                         90       100
                 ....*....|....*....|....
gi 503348417  75 CGGDKS--TQQADIRKAKQLAKQW 96
Cdd:COG4679   84 GFQKKTqkTPKKEIELARKRLKEY 107
Gp49 pfam05973
Phage derived protein Gp49-like (DUF891); This family consists of hypothetical bacterial ...
 12-94 2.63e-11

Phage derived protein Gp49-like (DUF891); This family consists of hypothetical bacterial proteins of unknown function as well as phage Gp49 proteins.


Pssm-ID: 461791  Cd Length: 90  Bit Score: 54.51  E-value: 2.63e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503348417  12 KWLRSLkDRTAKAKILMRLERMEDGNFGDVEP----IGDGLSELRIHQGKG-YRV-YFGNKNNQIILLlCGGDKSTQQ-- 83
Cdd:pfam05973  1 DELDAL-PDKVRAKFLAALDLLEEGGPDLGKPlvkkLGGGLWELRVRDAGGiYRVlYAFDPGRAVYVL-HAFQKKTQKtp 78

                         90
                 ....*....|..
gi 503348417  84 -ADIRKAKQLAK 94
Cdd:pfam05973 79 kKEIDLAERRLK 90
COG4683 COG4683
Uncharacterized conserved protein [Function unknown];
1-96 1.54e-04

Uncharacterized conserved protein [Function unknown];


Pssm-ID: 443719  Cd Length: 119  Bit Score: 37.47  E-value: 1.54e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503348417   1 MIEIKRTPEVEKWLRSLkDRTAKAKILMRLERMEDGNFGDVEPIGDGLS--------ELRI-HQGKGYRVYFG-NKNNQI 70
Cdd:COG4683    2 MWEVEFTDEFEEWFDAL-DEDVQEEVLAALLLLEEFGPQLGRPYVDTLKgsrhanmkELRVqSAGGPIRVFFAfDPRRQA 80

                         90       100       110
                 ....*....|....*....|....*....|.
gi 503348417  71 ILLlCGGDKSTQQ-----ADIRKAKQLAKQW 96
Cdd:COG4683   81 ILL-VAGDKSGNEkrfyrQLIPIADRRFDEH 110
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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