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MarR family winged helix-turn-helix transcriptional regulator [Paraburkholderia phenoliruptrix]

Protein Classification

MarR family winged helix-turn-helix transcriptional regulator( domain architecture ID 11448790)

MarR family winged helix-turn-helix (wHTH) transcriptional regulator similar to Bacillus thuringiensis DNA-binding transcriptional repressor TubR, a DNA-binding protein that is part of the type III plasmid partition system used to ensure correct segregation of the pBtoxis plasmid

Gene Ontology:  GO:0006355|GO:0003700
PubMed:  10498949|28670937
SCOP:  4000246

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
MarR COG1846
DNA-binding transcriptional regulator, MarR family [Transcription];
13-140 3.72e-23

DNA-binding transcriptional regulator, MarR family [Transcription];


:

Pssm-ID: 441451 [Multi-domain]  Cd Length: 142  Bit Score: 90.41  E-value: 3.72e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503355421  13 RVTHSLLRLSTAMRSQAWEWAEGAGLTPTQGEILVLLMqRKGPMRLGEIARETALTAATTSDAVSTLETKGLVEKRRALD 92
Cdd:COG1846   11 RLGLLLRRLARALRRALDRALAELGLTPAQFRVLAALA-EAGGLTQSELAERLGLTKSTVSRLLDRLEEKGLVEREPDPE 89

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*....
gi 503355421  93 DGRALAVRLTARGRTAAKRAAQ-WPDFLAKAVGTLRDDEQAMFYRTLLK 140
Cdd:COG1846   90 DRRAVLVRLTEKGRALLEEARPaLEALLAELLAGLSEEELEALLRLLRR 138
 
Name Accession Description Interval E-value
MarR COG1846
DNA-binding transcriptional regulator, MarR family [Transcription];
13-140 3.72e-23

DNA-binding transcriptional regulator, MarR family [Transcription];


Pssm-ID: 441451 [Multi-domain]  Cd Length: 142  Bit Score: 90.41  E-value: 3.72e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503355421  13 RVTHSLLRLSTAMRSQAWEWAEGAGLTPTQGEILVLLMqRKGPMRLGEIARETALTAATTSDAVSTLETKGLVEKRRALD 92
Cdd:COG1846   11 RLGLLLRRLARALRRALDRALAELGLTPAQFRVLAALA-EAGGLTQSELAERLGLTKSTVSRLLDRLEEKGLVEREPDPE 89

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*....
gi 503355421  93 DGRALAVRLTARGRTAAKRAAQ-WPDFLAKAVGTLRDDEQAMFYRTLLK 140
Cdd:COG1846   90 DRRAVLVRLTEKGRALLEEARPaLEALLAELLAGLSEEELEALLRLLRR 138
HTH_MARR smart00347
helix_turn_helix multiple antibiotic resistance protein;
37-114 7.03e-12

helix_turn_helix multiple antibiotic resistance protein;


Pssm-ID: 197670 [Multi-domain]  Cd Length: 101  Bit Score: 59.53  E-value: 7.03e-12
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 503355421    37 GLTPTQGEILVLLmQRKGPMRLGEIARETALTAATTSDAVSTLETKGLVEKRRALDDGRALAVRLTARGRTAAKRAAQ 114
Cdd:smart00347   7 GLTPTQFLVLRIL-YEEGPLSVSELAKRLGVSPSTVTRVLDRLEKKGLVRREPSPEDRRSVLVSLTEEGRELIEQLLE 83
MarR_2 pfam12802
MarR family; The Mar proteins are involved in the multiple antibiotic resistance, a ...
 37-96 9.23e-10

MarR family; The Mar proteins are involved in the multiple antibiotic resistance, a non-specific resistance system. The expression of the mar operon is controlled by a repressor, MarR. A large number of compounds induce transcription of the mar operon. This is thought to be due to the compound binding to MarR, and the resulting complex stops MarR binding to the DNA. With the MarR repression lost, transcription of the operon proceeds. The structure of MarR is known and shows MarR as a dimer with each subunit containing a winged-helix DNA binding motif.


Pssm-ID: 432797 [Multi-domain]  Cd Length: 60  Bit Score: 52.59  E-value: 9.23e-10
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 503355421   37 GLTPTQGEILVLLmQRKGPMRLGEIARETALTAATTSDAVSTLETKGLVEKRRALDDGRA 96
Cdd:pfam12802   2 GLTPAQFRVLLAL-ARNPGLTVAELARRLGISKQTVSRLVKRLEAKGLVEREPSPADRRA 60
HTH_ARSR cd00090
Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric ...
 40-106 8.93e-07

Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to dissociate from DNA in the presence of metal ions.


Pssm-ID: 238042 [Multi-domain]  Cd Length: 78  Bit Score: 44.98  E-value: 8.93e-07
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 503355421  40 PTQGEILVLLMqrKGPMRLGEIARETALTAATTSDAVSTLETKGLVEKRRaldDGRALAVRLTARGR 106
Cdd:cd00090    7 PTRLRILRLLL--EGPLTVSELAERLGLSQSTVSRHLKKLEEAGLVESRR---EGRRVYYSLTDAER 68
cas_HTH TIGR01884
CRISPR locus-related DNA-binding protein; Most but not all examples of this family are ...
 36-87 2.88e-03

CRISPR locus-related DNA-binding protein; Most but not all examples of this family are associated with CRISPR loci, a combination of DNA repeats and characteristic proteins encoded near the repeat cluster. The C-terminal region of this protein is homologous to DNA-binding helix-turn-helix domains with predicted transcriptional regulatory activity. [Regulatory functions, DNA interactions, , ]


Pssm-ID: 273852 [Multi-domain]  Cd Length: 203  Bit Score: 37.34  E-value: 2.88e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 503355421   36 AGLTPTQGEILVLLMQrKGPMRLGEIARETALTAATTSDAVSTLETKGLVEK 87
Cdd:TIGR01884 139 AGLSREELKILEVLKA-TGEKSVKNIAKKLGKSLSTISRHLAELEKKGLVEQ 189
 
Name Accession Description Interval E-value
MarR COG1846
DNA-binding transcriptional regulator, MarR family [Transcription];
13-140 3.72e-23

DNA-binding transcriptional regulator, MarR family [Transcription];


Pssm-ID: 441451 [Multi-domain]  Cd Length: 142  Bit Score: 90.41  E-value: 3.72e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503355421  13 RVTHSLLRLSTAMRSQAWEWAEGAGLTPTQGEILVLLMqRKGPMRLGEIARETALTAATTSDAVSTLETKGLVEKRRALD 92
Cdd:COG1846   11 RLGLLLRRLARALRRALDRALAELGLTPAQFRVLAALA-EAGGLTQSELAERLGLTKSTVSRLLDRLEEKGLVEREPDPE 89

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*....
gi 503355421  93 DGRALAVRLTARGRTAAKRAAQ-WPDFLAKAVGTLRDDEQAMFYRTLLK 140
Cdd:COG1846   90 DRRAVLVRLTEKGRALLEEARPaLEALLAELLAGLSEEELEALLRLLRR 138
HTH_MARR smart00347
helix_turn_helix multiple antibiotic resistance protein;
37-114 7.03e-12

helix_turn_helix multiple antibiotic resistance protein;


Pssm-ID: 197670 [Multi-domain]  Cd Length: 101  Bit Score: 59.53  E-value: 7.03e-12
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 503355421    37 GLTPTQGEILVLLmQRKGPMRLGEIARETALTAATTSDAVSTLETKGLVEKRRALDDGRALAVRLTARGRTAAKRAAQ 114
Cdd:smart00347   7 GLTPTQFLVLRIL-YEEGPLSVSELAKRLGVSPSTVTRVLDRLEKKGLVRREPSPEDRRSVLVSLTEEGRELIEQLLE 83
MarR_2 pfam12802
MarR family; The Mar proteins are involved in the multiple antibiotic resistance, a ...
 37-96 9.23e-10

MarR family; The Mar proteins are involved in the multiple antibiotic resistance, a non-specific resistance system. The expression of the mar operon is controlled by a repressor, MarR. A large number of compounds induce transcription of the mar operon. This is thought to be due to the compound binding to MarR, and the resulting complex stops MarR binding to the DNA. With the MarR repression lost, transcription of the operon proceeds. The structure of MarR is known and shows MarR as a dimer with each subunit containing a winged-helix DNA binding motif.


Pssm-ID: 432797 [Multi-domain]  Cd Length: 60  Bit Score: 52.59  E-value: 9.23e-10
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 503355421   37 GLTPTQGEILVLLmQRKGPMRLGEIARETALTAATTSDAVSTLETKGLVEKRRALDDGRA 96
Cdd:pfam12802   2 GLTPAQFRVLLAL-ARNPGLTVAELARRLGISKQTVSRLVKRLEAKGLVEREPSPADRRA 60
COG2512 COG2512
Predicted transcriptional regulator, contains CW (cell wall-binding) repeats and an HTH domain ...
 36-108 1.01e-09

Predicted transcriptional regulator, contains CW (cell wall-binding) repeats and an HTH domain [General function prediction only];


Pssm-ID: 442002 [Multi-domain]  Cd Length: 80  Bit Score: 53.38  E-value: 1.01e-09
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 503355421  36 AGLTPTQGEILVLLMQRKGPMRLGEIARETALTAATTSDAVSTLETKGLVEKRRAlddGRALAVRLTARGRTA 108
Cdd:COG2512   11 PELLEDERRVLELLRENGGRMTQSEIVKETGWSKSKVSRLLSRLEERGLIEKERV---GRENVVELPEDEPEA 80
MntR COG1321
Mn-dependent transcriptional regulator MntR, DtxR family [Transcription];
44-124 1.63e-08

Mn-dependent transcriptional regulator MntR, DtxR family [Transcription];


Pssm-ID: 440932 [Multi-domain]  Cd Length: 135  Bit Score: 51.36  E-value: 1.63e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503355421  44 EILVLLMQRKGPMRLGEIARETALTAATTSDAVSTLETKGLVEKRRalDDGralaVRLTARGRTAAKRAAQ----WPDFL 119
Cdd:COG1321   13 KAIYELSEEGGPVRTSDIAERLGVSPPSVTEMLKKLEEKGLVEYEP--YGG----ITLTEEGRELALRIVRrhrlLERFL 86


                 ....*
gi 503355421 120 AKAVG 124
Cdd:COG1321   87 VEVLG 91
MarR pfam01047
MarR family; The Mar proteins are involved in the multiple antibiotic resistance, a ...
 38-96 6.67e-08

MarR family; The Mar proteins are involved in the multiple antibiotic resistance, a non-specific resistance system. The expression of the mar operon is controlled by a repressor, MarR. A large number of compounds induce transcription of the mar operon. This is thought to be due to the compound binding to MarR, and the resulting complex stops MarR binding to the DNA. With the MarR repression lost, transcription of the operon proceeds. The structure of MarR is known and shows MarR as a dimer with each subunit containing a winged-helix DNA binding motif.


Pssm-ID: 426012 [Multi-domain]  Cd Length: 59  Bit Score: 47.54  E-value: 6.67e-08
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 503355421   38 LTPTQGEILVLLMQRkGPMRLGEIARETALTAATTSDAVSTLETKGLVEKRRALDDGRA 96
Cdd:pfam01047   1 LTLTQFHILRILYEH-GPLTVSELAEKLGVSKSTVTRVLDRLEKKGLIERSRSPEDRRE 58
HTH_27 pfam13463
Winged helix DNA-binding domain;
38-105 1.55e-07

Winged helix DNA-binding domain;


Pssm-ID: 433228 [Multi-domain]  Cd Length: 68  Bit Score: 46.90  E-value: 1.55e-07
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 503355421   38 LTPTQGEILVLLMQRKGPMRLGEIARETALTAATTSDAVSTLETKGLVEKRRALDDGRALAVRLTARG 105
Cdd:pfam13463   1 LTRLEALILHNIGHRGDPKTLADICFRLNVEDSHVSYSLKKLTEAGLVEREGSEEDGRETRVRLTAKG 68
HTH_ARSR cd00090
Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric ...
 40-106 8.93e-07

Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to dissociate from DNA in the presence of metal ions.


Pssm-ID: 238042 [Multi-domain]  Cd Length: 78  Bit Score: 44.98  E-value: 8.93e-07
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 503355421  40 PTQGEILVLLMqrKGPMRLGEIARETALTAATTSDAVSTLETKGLVEKRRaldDGRALAVRLTARGR 106
Cdd:cd00090    7 PTRLRILRLLL--EGPLTVSELAERLGLSQSTVSRHLKKLEEAGLVESRR---EGRRVYYSLTDAER 68
COG3355 COG3355
Predicted transcriptional regulator [Transcription];
37-94 6.81e-06

Predicted transcriptional regulator [Transcription];


Pssm-ID: 442583 [Multi-domain]  Cd Length: 131  Bit Score: 43.80  E-value: 6.81e-06
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 503355421  37 GLTPTQGEILVLLMQRKGPMRLGEIARETALTAATTSDAVSTLETKGLVEKRRALDDG 94
Cdd:COG3355   24 GLSETDAEVYLILLENGEPLTVEELAEALDRSRSTVYRSLQKLLEAGLVEREKRNLEG 81
GbsR COG1510
DNA-binding transcriptional regulator GbsR, MarR family [Transcription];
31-89 7.54e-06

DNA-binding transcriptional regulator GbsR, MarR family [Transcription];


Pssm-ID: 441119  Cd Length: 164  Bit Score: 44.54  E-value: 7.54e-06
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 503355421  31 EWAEGAGLTPTQGEILVLLMQRKGPMRLGEIARETALTAATTSDAVSTLETKGLVEKRR 89
Cdd:COG1510   18 EMGERWGLPRSAGRIYALLYLSDEPLTADELAEELGVSKSSVSTALRELEDWGLVRRVR 76
COG3398 COG3398
Predicted transcriptional regulator, contains two HTH domains [Transcription];
40-102 1.64e-05

Predicted transcriptional regulator, contains two HTH domains [Transcription];


Pssm-ID: 442625 [Multi-domain]  Cd Length: 159  Bit Score: 43.33  E-value: 1.64e-05
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 503355421  40 PTQGEILVLLMqRKGPMRLGEIARETALTAATTSDAVSTLETKGLVEKRRaldDGRALAVRLT 102
Cdd:COG3398   97 ETPRRILLYLL-ENPGATNKELAEELGISRSTVSWHLKRLEEDGLVERER---DGRNVRYYLN 155
HTH_ARSR smart00418
helix_turn_helix, Arsenical Resistance Operon Repressor;
44-102 3.54e-05

helix_turn_helix, Arsenical Resistance Operon Repressor;


Pssm-ID: 197713 [Multi-domain]  Cd Length: 66  Bit Score: 40.27  E-value: 3.54e-05
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 503355421    44 EILVLLmqRKGPMRLGEIARETALTAATTSDAVSTLETKGLVEKRRaldDGRALAVRLT 102
Cdd:smart00418   1 KILKLL--AEGELCVCELAEILGLSQSTVSHHLKKLREAGLVESRR---EGKRVYYSLT 54
HTH_IclR pfam09339
IclR helix-turn-helix domain;
44-89 4.26e-05

IclR helix-turn-helix domain;


Pssm-ID: 430539 [Multi-domain]  Cd Length: 52  Bit Score: 39.70  E-value: 4.26e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 503355421   44 EILVLLMQRKGPMRLGEIARETALTAATTSDAVSTLETKGLVEKRR 89
Cdd:pfam09339   7 AILDALAEAPGPLTLTEIARRTGLPKSTAHRLLQTLVELGYVEQDP 52
COG4742 COG4742
Predicted transcriptional regulator, contains HTH domain [Transcription];
44-110 1.15e-04

Predicted transcriptional regulator, contains HTH domain [Transcription];


Pssm-ID: 443776 [Multi-domain]  Cd Length: 267  Bit Score: 41.80  E-value: 1.15e-04
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 503355421  44 EILVLLmqRKGPMRLGEIARETALTAATTSDAVSTLETKGLVEKrralDDGRalaVRLTARGRTAAK 110
Cdd:COG4742   20 NILLLL--AEGPKTRSELAESLDVSRSTILRQLKELEERGLIER----DDGE---YELTTLGRLVVE 77
IclR COG1414
DNA-binding transcriptional regulator, IclR family [Transcription];
44-111 2.16e-04

DNA-binding transcriptional regulator, IclR family [Transcription];


Pssm-ID: 441024 [Multi-domain]  Cd Length: 253  Bit Score: 40.96  E-value: 2.16e-04
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 503355421  44 EILVLLMQRKGPMRLGEIARETALTAATTSDAVSTLETKGLVEKRRalDDGR-ALAVRLTARGRTAAKR 111
Cdd:COG1414   13 AILEALAEAGGGLSLSELARRLGLPKSTVHRLLATLEEEGYVERDP--EGGRyRLGPRLLELGSAALRR 79
YrhO COG1378
Sugar-specific transcriptional regulator TrmB [Transcription];
34-135 9.23e-04

Sugar-specific transcriptional regulator TrmB [Transcription];


Pssm-ID: 440988 [Multi-domain]  Cd Length: 238  Bit Score: 39.23  E-value: 9.23e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503355421  34 EGAGLTPTQGEILVLLMqRKGPMRLGEIARETALTAATTSDAVSTLETKGLVEKR-------RALDDGRALAvRLTARGR 106
Cdd:COG1378    7 EKLGLSEYEAKVYLALL-ELGPATASELAKASGVPRSRVYDVLESLEEKGLVEVSegrpkryRAVPPEEALE-RLLEERE 84

                         90       100
                 ....*....|....*....|....*....
gi 503355421 107 TAAKRAAQWpdfLAKAVGTLRDDEQAMFY 135
Cdd:COG1378   85 EELEELREE---LEELYEELREPEEELVW 110
TrmB pfam01978
Sugar-specific transcriptional regulator TrmB; One member of this family, TrmB, has been shown ...
 37-89 1.53e-03

Sugar-specific transcriptional regulator TrmB; One member of this family, TrmB, has been shown to be a sugar-specific transcriptional regulator of the trehalose/maltose ABC transporter in Thermococcus litoralis.


Pssm-ID: 396525 [Multi-domain]  Cd Length: 67  Bit Score: 35.96  E-value: 1.53e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 503355421   37 GLTPTQGEILVLLMQRkGPMRLGEIARETALTAATTSDAVSTLETKGLVEKRR 89
Cdd:pfam01978   5 GLSEYEAKVYLALLKL-GPATADEIAEESGVPRSKVYEVLRSLEDKGLVEREK 56
ArsR COG0640
DNA-binding transcriptional regulator, ArsR family [Transcription];
40-102 2.25e-03

DNA-binding transcriptional regulator, ArsR family [Transcription];


Pssm-ID: 440405 [Multi-domain]  Cd Length: 92  Bit Score: 36.02  E-value: 2.25e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 503355421  40 PTQGEILVLLMQrkGPMRLGEIARETALTAATTSDAVSTLETKGLVEKRRaldDGRALAVRLT 102
Cdd:COG0640   20 PTRLRILRLLAE--GELCVGELAEALGLSQSTVSHHLKVLREAGLVTSRR---EGRWVYYRLA 77
cas_HTH TIGR01884
CRISPR locus-related DNA-binding protein; Most but not all examples of this family are ...
 36-87 2.88e-03

CRISPR locus-related DNA-binding protein; Most but not all examples of this family are associated with CRISPR loci, a combination of DNA repeats and characteristic proteins encoded near the repeat cluster. The C-terminal region of this protein is homologous to DNA-binding helix-turn-helix domains with predicted transcriptional regulatory activity. [Regulatory functions, DNA interactions, , ]


Pssm-ID: 273852 [Multi-domain]  Cd Length: 203  Bit Score: 37.34  E-value: 2.88e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 503355421   36 AGLTPTQGEILVLLMQrKGPMRLGEIARETALTAATTSDAVSTLETKGLVEK 87
Cdd:TIGR01884 139 AGLSREELKILEVLKA-TGEKSVKNIAKKLGKSLSTISRHLAELEKKGLVEQ 189
HTH_5 pfam01022
Bacterial regulatory protein, arsR family; Members of this family contains a DNA binding ...
 39-85 4.52e-03

Bacterial regulatory protein, arsR family; Members of this family contains a DNA binding 'helix-turn-helix' motif. This family includes other proteins which are not included in the Prosite definition.


Pssm-ID: 425993 [Multi-domain]  Cd Length: 45  Bit Score: 33.96  E-value: 4.52e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*..
gi 503355421   39 TPTQGEILVLLmqRKGPMRLGEIARETALTAATTSDAVSTLETKGLV 85
Cdd:pfam01022   1 DPTRLKILKLL--AEGELCVCELAEELGLSQSTVSHHLKKLREAGLV 45
COG2345 COG2345
Predicted transcriptional regulator, ArsR family [Transcription];
33-128 4.93e-03

Predicted transcriptional regulator, ArsR family [Transcription];


Pssm-ID: 441914 [Multi-domain]  Cd Length: 217  Bit Score: 36.82  E-value: 4.93e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503355421  33 AEGAGLTPTQGEILVLLmQRKGPMRLGEIARETALTAATTSDAVSTLETKGLVEkRRALDDGR---ALAVRLTARGRTAA 109
Cdd:COG2345    6 ALAALADPTRRRILELL-KRAGPVTAAELAEALGLTPNAVRRHLDALEEEGLVE-RETERRGRgrpAKLYRLTEAGRARF 83

                         90
                 ....*....|....*....
gi 503355421 110 KRAAQwpDFLAKAVGTLRD 128
Cdd:COG2345   84 PRAYD--DLAVALLDALRE 100
HTH_CRP cd00092
helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic ...
 49-88 7.79e-03

helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family.


Pssm-ID: 238044 [Multi-domain]  Cd Length: 67  Bit Score: 33.79  E-value: 7.79e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|
gi 503355421  49 LMQRKGPMRLGEIARETALTAATTSDAVSTLETKGLVEKR 88
Cdd:cd00092   19 GDLVQLPLTRQEIADYLGLTRETVSRTLKELEEEGLISRR 58
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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