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Conserved domains on  [gi|503382710|ref|WP_013617371|]
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GNAT family N-acetyltransferase [Phocaeicola salanitronis]

Protein Classification

GNAT family N-acetyltransferase( domain architecture ID 11441181)

GNAT family N-acetyltransferase catalyzes the transfer of an acetyl group from acetyl-CoA to a substrate

CATH:  3.40.630.30
EC:  2.3.-.-
Gene Ontology:  GO:0016746|GO:0008080
PubMed:  27367672|26818562|15581578|10940244
SCOP:  3000403

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
MnaT COG1247
L-amino acid N-acyltransferase MnaT [Amino acid transport and metabolism];
1-165 1.20e-16

L-amino acid N-acyltransferase MnaT [Amino acid transport and metabolism];


:

Pssm-ID: 440860 [Multi-domain]  Cd Length: 163  Bit Score: 72.72  E-value: 1.20e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503382710   1 MFTIRKATLEDIPLINKLAWEAFP---ATY-KDILTPEQivyMMDWMyspenlhKQMTEEGHIYYIAFRENEGAGYVSIQ 76
Cdd:COG1247    1 EMTIRPATPEDAPAIAAIYNEAIAegtATFeTEPPSEEE---REAWF-------AAILAPGRPVLVAEEDGEVVGFASLG 70

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503382710  77 P----EGEGLFHLQKIYVLPQYQKHHLGKLLFGQAVRGIKELhpGPCRMELNVNREN-PALGFYRHMGMEKV-REEDTHI 150
Cdd:COG1247   71 PfrprPAYRGTAEESIYVDPDARGRGIGRALLEALIERARAR--GYRRLVAVVLADNeASIALYEKLGFEEVgTLPEVGF 148

                        170
                 ....*....|....*
gi 503382710 151 GNGFYMNDYIMGLSI 165
Cdd:COG1247  149 KFGRWLDLVLMQKRL 163
 
Name Accession Description Interval E-value
MnaT COG1247
L-amino acid N-acyltransferase MnaT [Amino acid transport and metabolism];
1-165 1.20e-16

L-amino acid N-acyltransferase MnaT [Amino acid transport and metabolism];


Pssm-ID: 440860 [Multi-domain]  Cd Length: 163  Bit Score: 72.72  E-value: 1.20e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503382710   1 MFTIRKATLEDIPLINKLAWEAFP---ATY-KDILTPEQivyMMDWMyspenlhKQMTEEGHIYYIAFRENEGAGYVSIQ 76
Cdd:COG1247    1 EMTIRPATPEDAPAIAAIYNEAIAegtATFeTEPPSEEE---REAWF-------AAILAPGRPVLVAEEDGEVVGFASLG 70

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503382710  77 P----EGEGLFHLQKIYVLPQYQKHHLGKLLFGQAVRGIKELhpGPCRMELNVNREN-PALGFYRHMGMEKV-REEDTHI 150
Cdd:COG1247   71 PfrprPAYRGTAEESIYVDPDARGRGIGRALLEALIERARAR--GYRRLVAVVLADNeASIALYEKLGFEEVgTLPEVGF 148

                        170
                 ....*....|....*
gi 503382710 151 GNGFYMNDYIMGLSI 165
Cdd:COG1247  149 KFGRWLDLVLMQKRL 163
Acetyltransf_10 pfam13673
Acetyltransferase (GNAT) domain; This family contains proteins with N-acetyltransferase ...
 45-146 8.85e-13

Acetyltransferase (GNAT) domain; This family contains proteins with N-acetyltransferase functions such as Elp3-related proteins.


Pssm-ID: 463953 [Multi-domain]  Cd Length: 128  Bit Score: 61.52  E-value: 8.85e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503382710   45 SPENLHKQMTEEGHIYYIAFRENEGAGYVSIQPEGeglfHLQKIYVLPQYQKHHLGKLLFGQAVRGIKELHPGpcRMELN 124
Cdd:pfam13673  18 SPEALRERIDQGEYFFFVAFEGGQIVGVIALRDRG----HISLLFVDPDYQGQGIGKALLEAVEDYAEKDGIK--LSELT 91

                          90       100
                  ....*....|....*....|..
gi 503382710  125 VNRENPALGFYRHMGMEKVREE 146
Cdd:pfam13673  92 VNASPYAVPFYEKLGFRATGPE 113
Spm_actase_Thplmales NF041158
spermidine N(1)-acetyltransferase;
1-112 6.12e-07

spermidine N(1)-acetyltransferase;


Pssm-ID: 469070  Cd Length: 115  Bit Score: 45.69  E-value: 6.12e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503382710   1 MFTIRKATLEDIPLINKLAWEAFPATYKDILTPEQIVYMMDWMYSPENLHKQMTEEGH----IYYIAFRENEGAGYVSIQ 76
Cdd:NF041158   1 MITIRKLSAEDVDALIEVARESWKWTYRDIYSNEFIESWISEKYSKEKLLNEIIRSQSnldiIFLGAFVNSALIGFIELK 80

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 503382710  77 PEGEGLfHLQKIYVLPQYQKHHLGKLLFGQAVRGIK 112
Cdd:NF041158  81 IIADKA-ELLRLYLKPEYTHRGIGKLLLSEAEKIMK 115
PRK10514 PRK10514
putative acetyltransferase; Provisional
 84-141 3.28e-05

putative acetyltransferase; Provisional


Pssm-ID: 182510 [Multi-domain]  Cd Length: 145  Bit Score: 41.53  E-value: 3.28e-05
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 503382710  84 HLQKIYVLPQYQKHHLGKLLFGQAVrgikELHPgpcRMELNVNRENP-ALGFYRHMGME 141
Cdd:PRK10514  71 HMEALFVDPDVRGCGVGRMLVEHAL----SLHP---ELTTDVNEQNEqAVGFYKKMGFK 122
NAT_SF cd04301
N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer ...
 60-124 1.24e-04

N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; NAT (N-Acyltransferase) is a large superfamily of enzymes that mostly catalyze the transfer of an acyl group to a substrate and are implicated in a variety of functions, ranging from bacterial antibiotic resistance to circadian rhythms in mammals. Members include GCN5-related N-Acetyltransferases (GNAT) such as Aminoglycoside N-acetyltransferases, Histone N-acetyltransferase (HAT) enzymes, and Serotonin N-acetyltransferase, which catalyze the transfer of an acetyl group to a substrate. The kinetic mechanism of most GNATs involves the ordered formation of a ternary complex: the reaction begins with Acetyl Coenzyme A (AcCoA) binding, followed by binding of substrate, then direct transfer of the acetyl group from AcCoA to the substrate, followed by product and subsequent CoA release. Other family members include Arginine/ornithine N-succinyltransferase, Myristoyl-CoA: protein N-myristoyltransferase, and Acyl-homoserinelactone synthase which have a similar catalytic mechanism but differ in types of acyl groups transferred. Leucyl/phenylalanyl-tRNA-protein transferase and FemXAB nonribosomal peptidyltransferases which catalyze similar peptidyltransferase reactions are also included.


Pssm-ID: 173926 [Multi-domain]  Cd Length: 65  Bit Score: 38.41  E-value: 1.24e-04
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 503382710  60 YYIAFRENEGAGYVSI--QPEGEGLFHLQKIYVLPQYQKHHLGKLLFGQAVRGIKELhpGPCRMELN 124
Cdd:cd04301    1 FLVAEDDGEIVGFASLspDGSGGDTAYIGDLAVLPEYRGKGIGSALLEAAEEEARER--GAKRLRLE 65
 
Name Accession Description Interval E-value
MnaT COG1247
L-amino acid N-acyltransferase MnaT [Amino acid transport and metabolism];
1-165 1.20e-16

L-amino acid N-acyltransferase MnaT [Amino acid transport and metabolism];


Pssm-ID: 440860 [Multi-domain]  Cd Length: 163  Bit Score: 72.72  E-value: 1.20e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503382710   1 MFTIRKATLEDIPLINKLAWEAFP---ATY-KDILTPEQivyMMDWMyspenlhKQMTEEGHIYYIAFRENEGAGYVSIQ 76
Cdd:COG1247    1 EMTIRPATPEDAPAIAAIYNEAIAegtATFeTEPPSEEE---REAWF-------AAILAPGRPVLVAEEDGEVVGFASLG 70

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503382710  77 P----EGEGLFHLQKIYVLPQYQKHHLGKLLFGQAVRGIKELhpGPCRMELNVNREN-PALGFYRHMGMEKV-REEDTHI 150
Cdd:COG1247   71 PfrprPAYRGTAEESIYVDPDARGRGIGRALLEALIERARAR--GYRRLVAVVLADNeASIALYEKLGFEEVgTLPEVGF 148

                        170
                 ....*....|....*
gi 503382710 151 GNGFYMNDYIMGLSI 165
Cdd:COG1247  149 KFGRWLDLVLMQKRL 163
Acetyltransf_10 pfam13673
Acetyltransferase (GNAT) domain; This family contains proteins with N-acetyltransferase ...
 45-146 8.85e-13

Acetyltransferase (GNAT) domain; This family contains proteins with N-acetyltransferase functions such as Elp3-related proteins.


Pssm-ID: 463953 [Multi-domain]  Cd Length: 128  Bit Score: 61.52  E-value: 8.85e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503382710   45 SPENLHKQMTEEGHIYYIAFRENEGAGYVSIQPEGeglfHLQKIYVLPQYQKHHLGKLLFGQAVRGIKELHPGpcRMELN 124
Cdd:pfam13673  18 SPEALRERIDQGEYFFFVAFEGGQIVGVIALRDRG----HISLLFVDPDYQGQGIGKALLEAVEDYAEKDGIK--LSELT 91

                          90       100
                  ....*....|....*....|..
gi 503382710  125 VNRENPALGFYRHMGMEKVREE 146
Cdd:pfam13673  92 VNASPYAVPFYEKLGFRATGPE 113
RimI COG0456
Ribosomal protein S18 acetylase RimI and related acetyltransferases [Translation, ribosomal ...
 71-156 7.61e-12

Ribosomal protein S18 acetylase RimI and related acetyltransferases [Translation, ribosomal structure and biogenesis];


Pssm-ID: 440224 [Multi-domain]  Cd Length: 92  Bit Score: 58.13  E-value: 7.61e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503382710  71 GYVSIQPE-GEGLFHLQKIYVLPQYQKHHLGKLLFGQAVRGIKELhpGPCRMELNVNREN-PALGFYRHMGMEKVREEDT 148
Cdd:COG0456    1 GFALLGLVdGGDEAEIEDLAVDPEYRGRGIGRALLEAALERARER--GARRLRLEVREDNeAAIALYEKLGFEEVGERPN 78


                 ....*...
gi 503382710 149 HIGNGFYM 156
Cdd:COG0456   79 YYGDDALV 86
ArgA COG1246
N-acetylglutamate synthase or related acetyltransferase, GNAT family [Amino acid transport and ...
 2-161 1.53e-11

N-acetylglutamate synthase or related acetyltransferase, GNAT family [Amino acid transport and metabolism]; N-acetylglutamate synthase or related acetyltransferase, GNAT family is part of the Pathway/BioSystem: Arginine biosynthesis


Pssm-ID: 440859 [Multi-domain]  Cd Length: 132  Bit Score: 58.46  E-value: 1.53e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503382710   2 FTIRKATLEDIPLINKLAWEAFpatykdiltpeqivymmdwmyspenlhkqMTEEGHIYYIAFRENEGAGYVSIQPEGEG 81
Cdd:COG1246    1 MTIRPATPDDVPAILELIRPYA-----------------------------LEEEIGEFWVAEEDGEIVGCAALHPLDED 51

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503382710  82 LFHLQKIYVLPQYQKHHLGKLLFGQAVRGIKELhpGPCRMELNVNRenPALGFYRHMGMEKVREEDTHIGNGFYMNDYIM 161
Cdd:COG1246   52 LAELRSLAVHPDYRGRGIGRRLLEALLAEAREL--GLKRLFLLTTS--AAIHFYEKLGFEEIDKEDLPYAKVWQRDSVVM 127
PhnO COG0454
N-acetyltransferase, GNAT superfamily (includes histone acetyltransferase HPA2) [Transcription, ...
 2-156 1.75e-11

N-acetyltransferase, GNAT superfamily (includes histone acetyltransferase HPA2) [Transcription, General function prediction only];


Pssm-ID: 440222 [Multi-domain]  Cd Length: 136  Bit Score: 58.53  E-value: 1.75e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503382710   2 FTIRKATLEDIPLINKLawEAFPATYKDILtpeqivymmdwmyspenlhkqMTEEGHIYYIAFRENEGAGYVSIQPEGEG 81
Cdd:COG0454    1 MSIRKATPEDINFILLI--EALDAELKAME---------------------GSLAGAEFIAVDDKGEPIGFAGLRRLDDK 57

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 503382710  82 LFHLQKIYVLPQYQKHHLGKLLFGQAVRGIKELhpGPCRMELNVNRENP-ALGFYRHMGMEKVREEDTHIGNGFYM 156
Cdd:COG0454   58 VLELKRLYVLPEYRGKGIGKALLEALLEWARER--GCTALELDTLDGNPaAIRFYERLGFKEIERYVAYVGGEFEK 131
yhbS COG3153
Predicted N-acetyltransferase YhbS [General function prediction only];
4-156 3.44e-10

Predicted N-acetyltransferase YhbS [General function prediction only];


Pssm-ID: 442387 [Multi-domain]  Cd Length: 142  Bit Score: 55.09  E-value: 3.44e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503382710   4 IRKATLEDIPLINKLAWEAFPATYkdiltPEQIVymmdwmyspENLHKQMTEEghIYYIAFRENEGAGYVSIQP----EG 79
Cdd:COG3153    1 IRPATPEDAEAIAALLRAAFGPGR-----EAELV---------DRLREDPAAG--LSLVAEDDGEIVGHVALSPvdidGE 64

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 503382710  80 EGLFHLQKIYVLPQYQKHHLGKLLFGQAVRGIKELhpGPCRMELNVNRENpaLGFYRHMGMEKVREEDTHIGNGFYM 156
Cdd:COG3153   65 GPALLLGPLAVDPEYRGQGIGRALMRAALEAARER--GARAVVLLGDPSL--LPFYERFGFRPAGELGLTLGPDEVF 137
ElaA COG2153
Predicted N-acyltransferase, GNAT family [General function prediction only];
55-146 7.19e-09

Predicted N-acyltransferase, GNAT family [General function prediction only];


Pssm-ID: 441756 [Multi-domain]  Cd Length: 134  Bit Score: 51.34  E-value: 7.19e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503382710  55 EEGHIYYIAFRENEGAGYVSIQPEGEGLFHLQKIYVLPQYQKHHLGKLLFGQAVRGIKELhpGPCRMELNVnREnPALGF 134
Cdd:COG2153   31 DEDARHLLAYDDGELVATARLLPPGDGEAKIGRVAVLPEYRGQGLGRALMEAAIEEARER--GARRIVLSA-QA-HAVGF 106

                         90
                 ....*....|..
gi 503382710 135 YRHMGMEKVREE 146
Cdd:COG2153  107 YEKLGFVPVGEE 118
Acetyltransf_7 pfam13508
Acetyltransferase (GNAT) domain; This domain catalyzes N-acetyltransferase reactions.
 56-139 1.27e-08

Acetyltransferase (GNAT) domain; This domain catalyzes N-acetyltransferase reactions.


Pssm-ID: 463905 [Multi-domain]  Cd Length: 84  Bit Score: 49.38  E-value: 1.27e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503382710   56 EGHIYYIAFRENEGAGYVSIQPEGEGLFHLQ-KIYVLPQYQKHHLGKLLfgqaVRGIKELHPGPCRMELNVNRENPALGF 134
Cdd:pfam13508   1 PGGRFFVAEDDGKIVGFAALLPLDDEGALAElRLAVHPEYRGQGIGRAL----LEAAEAAAKEGGIKLLELETTNRAAAF 76


                  ....*
gi 503382710  135 YRHMG 139
Cdd:pfam13508  77 YEKLG 81
Spm_actase_Thplmales NF041158
spermidine N(1)-acetyltransferase;
1-112 6.12e-07

spermidine N(1)-acetyltransferase;


Pssm-ID: 469070  Cd Length: 115  Bit Score: 45.69  E-value: 6.12e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503382710   1 MFTIRKATLEDIPLINKLAWEAFPATYKDILTPEQIVYMMDWMYSPENLHKQMTEEGH----IYYIAFRENEGAGYVSIQ 76
Cdd:NF041158   1 MITIRKLSAEDVDALIEVARESWKWTYRDIYSNEFIESWISEKYSKEKLLNEIIRSQSnldiIFLGAFVNSALIGFIELK 80

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 503382710  77 PEGEGLfHLQKIYVLPQYQKHHLGKLLFGQAVRGIK 112
Cdd:NF041158  81 IIADKA-ELLRLYLKPEYTHRGIGKLLLSEAEKIMK 115
Acetyltransf_1 pfam00583
Acetyltransferase (GNAT) family; This family contains proteins with N-acetyltransferase ...
 55-140 6.19e-06

Acetyltransferase (GNAT) family; This family contains proteins with N-acetyltransferase functions such as Elp3-related proteins.


Pssm-ID: 395465 [Multi-domain]  Cd Length: 116  Bit Score: 43.28  E-value: 6.19e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503382710   55 EEGHIYYIAFRENEGAGYVSIQPEGEGLFH--LQKIYVLPQYQKHHLGKLLFGQAVRGIKELhpGPCRMELNVNREN-PA 131
Cdd:pfam00583  30 DASEGFFVAEEDGELVGFASLSIIDDEPPVgeIEGLAVAPEYRGKGIGTALLQALLEWARER--GCERIFLEVAADNlAA 107


                  ....*....
gi 503382710  132 LGFYRHMGM 140
Cdd:pfam00583 108 IALYEKLGF 116
PRK10514 PRK10514
putative acetyltransferase; Provisional
 84-141 3.28e-05

putative acetyltransferase; Provisional


Pssm-ID: 182510 [Multi-domain]  Cd Length: 145  Bit Score: 41.53  E-value: 3.28e-05
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 503382710  84 HLQKIYVLPQYQKHHLGKLLFGQAVrgikELHPgpcRMELNVNRENP-ALGFYRHMGME 141
Cdd:PRK10514  71 HMEALFVDPDVRGCGVGRMLVEHAL----SLHP---ELTTDVNEQNEqAVGFYKKMGFK 122
NAT_SF cd04301
N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer ...
 60-124 1.24e-04

N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; NAT (N-Acyltransferase) is a large superfamily of enzymes that mostly catalyze the transfer of an acyl group to a substrate and are implicated in a variety of functions, ranging from bacterial antibiotic resistance to circadian rhythms in mammals. Members include GCN5-related N-Acetyltransferases (GNAT) such as Aminoglycoside N-acetyltransferases, Histone N-acetyltransferase (HAT) enzymes, and Serotonin N-acetyltransferase, which catalyze the transfer of an acetyl group to a substrate. The kinetic mechanism of most GNATs involves the ordered formation of a ternary complex: the reaction begins with Acetyl Coenzyme A (AcCoA) binding, followed by binding of substrate, then direct transfer of the acetyl group from AcCoA to the substrate, followed by product and subsequent CoA release. Other family members include Arginine/ornithine N-succinyltransferase, Myristoyl-CoA: protein N-myristoyltransferase, and Acyl-homoserinelactone synthase which have a similar catalytic mechanism but differ in types of acyl groups transferred. Leucyl/phenylalanyl-tRNA-protein transferase and FemXAB nonribosomal peptidyltransferases which catalyze similar peptidyltransferase reactions are also included.


Pssm-ID: 173926 [Multi-domain]  Cd Length: 65  Bit Score: 38.41  E-value: 1.24e-04
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 503382710  60 YYIAFRENEGAGYVSI--QPEGEGLFHLQKIYVLPQYQKHHLGKLLFGQAVRGIKELhpGPCRMELN 124
Cdd:cd04301    1 FLVAEDDGEIVGFASLspDGSGGDTAYIGDLAVLPEYRGKGIGSALLEAAEEEARER--GAKRLRLE 65
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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