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Conserved domains on  [gi|503421623|ref|WP_013656284|]
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SoxR reducing system RseC family protein [Cellulosilyticum lentocellum]

Protein Classification

SoxR reducing system RseC family protein( domain architecture ID 10515214)

SoxR reducing system RseC family protein, may play a role in the reduction of the iron-sulfur cluster regulatory protein SoxR

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
RseC_MucC pfam04246
Positive regulator of sigma(E), RseC/MucC; This bacterial family of integral membrane proteins ...
 6-134 2.70e-30

Positive regulator of sigma(E), RseC/MucC; This bacterial family of integral membrane proteins represents a positive regulator of the sigma(E) transcription factor, namely RseC/MucC. The sigma(E) transcription factor is up-regulated by cell envelope protein misfolding, and regulates the expression of genes that are collectively termed ECF (devoted to Extra-Cellular Functions). In Pseudomonas aeruginosa, de-repression of sigma(E) is associated with the alginate-overproducing phenotype characteriztic of chronic respiratory tract colonization in cystic fibrosis patients. The mechanism by which RseC/MucC positively regulates the sigma(E) transcription factor is unknown. RseC is also thought to have a role in thiamine biosynthesis in Salmonella typhimurium. In addition, this family also includes an N-terminal part of RnfF, a Rhodobacter capsulatus protein, of unknown function, that is essential for nitrogen fixation. This protein also contains an ApbE domain pfam02424, which is itself involved in thiamine biosynthesis.


:

Pssm-ID: 461236  Cd Length: 130  Bit Score: 105.74  E-value: 2.70e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503421623    6 VKEVGKRYAIVQMERQEMCGECHACD----YITGKKDCILRCEKEIECQVGDMVELKLAQPTFLKATYVMYGFPLIGLII 81
Cdd:pfam04246   1 VVAVEGGTAWVEIERKSACGSCAARSgcklGASGSKEKIIEVANPIGAKVGDRVEVGIPESSLLKAALLVYLLPLLGLIL 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....
gi 503421623   82 GLVIGLGAsklfrLGSEDLWVLIGGLLGIVLPLIGIKWAENQGKFK-KYLPHII 134
Cdd:pfam04246  81 GALLGQAL-----LGGSELAAALGGLLGLALGFLILRLLDRRLKKKgKFQPVIL 129
 
Name Accession Description Interval E-value
RseC_MucC pfam04246
Positive regulator of sigma(E), RseC/MucC; This bacterial family of integral membrane proteins ...
 6-134 2.70e-30

Positive regulator of sigma(E), RseC/MucC; This bacterial family of integral membrane proteins represents a positive regulator of the sigma(E) transcription factor, namely RseC/MucC. The sigma(E) transcription factor is up-regulated by cell envelope protein misfolding, and regulates the expression of genes that are collectively termed ECF (devoted to Extra-Cellular Functions). In Pseudomonas aeruginosa, de-repression of sigma(E) is associated with the alginate-overproducing phenotype characteriztic of chronic respiratory tract colonization in cystic fibrosis patients. The mechanism by which RseC/MucC positively regulates the sigma(E) transcription factor is unknown. RseC is also thought to have a role in thiamine biosynthesis in Salmonella typhimurium. In addition, this family also includes an N-terminal part of RnfF, a Rhodobacter capsulatus protein, of unknown function, that is essential for nitrogen fixation. This protein also contains an ApbE domain pfam02424, which is itself involved in thiamine biosynthesis.


Pssm-ID: 461236  Cd Length: 130  Bit Score: 105.74  E-value: 2.70e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503421623    6 VKEVGKRYAIVQMERQEMCGECHACD----YITGKKDCILRCEKEIECQVGDMVELKLAQPTFLKATYVMYGFPLIGLII 81
Cdd:pfam04246   1 VVAVEGGTAWVEIERKSACGSCAARSgcklGASGSKEKIIEVANPIGAKVGDRVEVGIPESSLLKAALLVYLLPLLGLIL 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....
gi 503421623   82 GLVIGLGAsklfrLGSEDLWVLIGGLLGIVLPLIGIKWAENQGKFK-KYLPHII 134
Cdd:pfam04246  81 GALLGQAL-----LGGSELAAALGGLLGLALGFLILRLLDRRLKKKgKFQPVIL 129
RseC COG3086
RseC, positive regulator of sigma E activity [Signal transduction mechanisms];
4-136 6.80e-30

RseC, positive regulator of sigma E activity [Signal transduction mechanisms];


Pssm-ID: 442320  Cd Length: 149  Bit Score: 105.35  E-value: 6.80e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503421623   4 GVVKEVGKRYAIVQMERQEMCGECHAC--------DYITGKKDCILRCEKEIECQVGDMVELKLAQPTFLKATYVMYGFP 75
Cdd:COG3086    6 GTVVAVEGGTAWVETQRKSACGSCAAKsgcgtgllSKLFPSKEHRLEVPNPLGLKVGDRVEVGIPESSLLKAALLVYLLP 85

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 503421623  76 LIGLIIGLVIGlgasKLFRLGSEDLWVLIGGLLGIVLPLIGIKWAENQGKFK-KYLPHIIAK 136
Cdd:COG3086   86 LLGLLLGALLG----QALGPGGSELLAALGGLLGLALGFLLARRLSRRLAKKsKYQPVILRI 143
PRK10862 PRK10862
SoxR-reducing system protein RseC;
14-134 8.82e-06

SoxR-reducing system protein RseC;


Pssm-ID: 182788  Cd Length: 154  Bit Score: 42.65  E-value: 8.82e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503421623  14 AIVQMERQEMCGECHA---C-----DYITGKKDCILRCEKEIECQVGDMVELKLAQPTFLKATYVMYGFPLIGLIIGlvi 85
Cdd:PRK10862  16 ALLRCEVKAGCSSCASragCgsrllNKLGPQTTHQLVVPSSQPLVPGQKVELGIAEGSLLRSALLVYMTPLVGLFLG--- 92

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|
gi 503421623  86 glGASKLFRLGSeDLWVLIGGLLGIVLPLIGIK-WAENQGKFKKYLPHII 134
Cdd:PRK10862  93 --AALFQLLFGS-DLAALCGALLGGVGGFLLARgLSRKLAARAAYQPVIL 139
 
Name Accession Description Interval E-value
RseC_MucC pfam04246
Positive regulator of sigma(E), RseC/MucC; This bacterial family of integral membrane proteins ...
 6-134 2.70e-30

Positive regulator of sigma(E), RseC/MucC; This bacterial family of integral membrane proteins represents a positive regulator of the sigma(E) transcription factor, namely RseC/MucC. The sigma(E) transcription factor is up-regulated by cell envelope protein misfolding, and regulates the expression of genes that are collectively termed ECF (devoted to Extra-Cellular Functions). In Pseudomonas aeruginosa, de-repression of sigma(E) is associated with the alginate-overproducing phenotype characteriztic of chronic respiratory tract colonization in cystic fibrosis patients. The mechanism by which RseC/MucC positively regulates the sigma(E) transcription factor is unknown. RseC is also thought to have a role in thiamine biosynthesis in Salmonella typhimurium. In addition, this family also includes an N-terminal part of RnfF, a Rhodobacter capsulatus protein, of unknown function, that is essential for nitrogen fixation. This protein also contains an ApbE domain pfam02424, which is itself involved in thiamine biosynthesis.


Pssm-ID: 461236  Cd Length: 130  Bit Score: 105.74  E-value: 2.70e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503421623    6 VKEVGKRYAIVQMERQEMCGECHACD----YITGKKDCILRCEKEIECQVGDMVELKLAQPTFLKATYVMYGFPLIGLII 81
Cdd:pfam04246   1 VVAVEGGTAWVEIERKSACGSCAARSgcklGASGSKEKIIEVANPIGAKVGDRVEVGIPESSLLKAALLVYLLPLLGLIL 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....
gi 503421623   82 GLVIGLGAsklfrLGSEDLWVLIGGLLGIVLPLIGIKWAENQGKFK-KYLPHII 134
Cdd:pfam04246  81 GALLGQAL-----LGGSELAAALGGLLGLALGFLILRLLDRRLKKKgKFQPVIL 129
RseC COG3086
RseC, positive regulator of sigma E activity [Signal transduction mechanisms];
4-136 6.80e-30

RseC, positive regulator of sigma E activity [Signal transduction mechanisms];


Pssm-ID: 442320  Cd Length: 149  Bit Score: 105.35  E-value: 6.80e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503421623   4 GVVKEVGKRYAIVQMERQEMCGECHAC--------DYITGKKDCILRCEKEIECQVGDMVELKLAQPTFLKATYVMYGFP 75
Cdd:COG3086    6 GTVVAVEGGTAWVETQRKSACGSCAAKsgcgtgllSKLFPSKEHRLEVPNPLGLKVGDRVEVGIPESSLLKAALLVYLLP 85

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 503421623  76 LIGLIIGLVIGlgasKLFRLGSEDLWVLIGGLLGIVLPLIGIKWAENQGKFK-KYLPHIIAK 136
Cdd:COG3086   86 LLGLLLGALLG----QALGPGGSELLAALGGLLGLALGFLLARRLSRRLAKKsKYQPVILRI 143
PRK10862 PRK10862
SoxR-reducing system protein RseC;
14-134 8.82e-06

SoxR-reducing system protein RseC;


Pssm-ID: 182788  Cd Length: 154  Bit Score: 42.65  E-value: 8.82e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503421623  14 AIVQMERQEMCGECHA---C-----DYITGKKDCILRCEKEIECQVGDMVELKLAQPTFLKATYVMYGFPLIGLIIGlvi 85
Cdd:PRK10862  16 ALLRCEVKAGCSSCASragCgsrllNKLGPQTTHQLVVPSSQPLVPGQKVELGIAEGSLLRSALLVYMTPLVGLFLG--- 92

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|
gi 503421623  86 glGASKLFRLGSeDLWVLIGGLLGIVLPLIGIK-WAENQGKFKKYLPHII 134
Cdd:PRK10862  93 --AALFQLLFGS-DLAALCGALLGGVGGFLLARgLSRKLAARAAYQPVIL 139
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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